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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium channel modulator
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Accession:CHEBI:39000 term browser browse the term
Synonyms:related_synonym: sodium channel modulators


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amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172 		JBrowse link
G PLG plasminogen multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867 		JBrowse link
bifenthrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 affects phosphorylation EXP bifenthrin affects the phosphorylation of AKT1 protein CTD PMID:33901951
G CCL14 C-C motif chemokine ligand 14 decreases expression EXP bifenthrin results in decreased expression of CCL14 mRNA CTD PMID:33901951 NCBI chr12:39,611,887...39,616,050
Ensembl chr12:39,611,868...39,616,159 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression EXP bifenthrin results in decreased expression of CCL4 mRNA CTD PMID:33901951 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP bifenthrin results in decreased expression of CCND1 mRNA CTD PMID:33901951 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CCNE1 cyclin E1 decreases expression EXP bifenthrin results in decreased expression of CCNE1 mRNA CTD PMID:33901951 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,366 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 decreases expression EXP bifenthrin results in decreased expression of CX3CL1 mRNA CTD PMID:33901951 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP bifenthrin results in increased expression of DDIT3 protein CTD PMID:33901951 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP bifenthrin results in increased phosphorylation of EIF2S1 protein CTD PMID:33901951 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP bifenthrin results in increased expression of HSPA5 protein CTD PMID:33901951 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G LEPR leptin receptor decreases expression EXP bifenthrin results in decreased expression of LEPR mRNA CTD PMID:33901951 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP bifenthrin results in increased phosphorylation of MAPK1 protein CTD PMID:33901951 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP bifenthrin results in increased phosphorylation of MAPK3 protein CTD PMID:33901951 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP bifenthrin results in increased phosphorylation of MAPK8 protein CTD PMID:33901951 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP bifenthrin results in decreased expression of PCNA protein CTD PMID:33901951 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744 		JBrowse link
G RARB retinoic acid receptor beta decreases expression EXP bifenthrin results in decreased expression of RARB mRNA CTD PMID:33901951 NCBI chr13:12,336,387...12,507,688
Ensembl chr13:12,336,972...12,507,680 		JBrowse link
G RPS6 ribosomal protein S6 increases phosphorylation EXP bifenthrin results in increased phosphorylation of RPS6 protein CTD PMID:33901951 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 affects phosphorylation EXP bifenthrin affects the phosphorylation of RPS6KB1 protein CTD PMID:33901951 NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376 		JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Capsaicin inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294 		JBrowse link
G TAC1 tachykinin precursor 1 increases secretion EXP Capsaicin results in increased secretion of TAC1 protein CTD PMID:10766449 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523 		JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions		 EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]		 CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5007
    role 4969
      biological role 4969
        biophysical role 191
          membrane transport modulator 105
            sodium channel modulator 24
              pyrethroid insecticide + 17
              sodium channel blocker + 7
              veratridine 0
paths to the root