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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium channel modulator
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Accession:CHEBI:39000 term browser browse the term
Synonyms:related_synonym: sodium channel modulators


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capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1B 5-hydroxytryptamine receptor 1B multiple interactions EXP HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] CTD PMID:16880765 NCBI chr12:38,659,088...38,659,546 JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity		 EXP JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17392452 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926 		JBrowse link
ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression
multiple interactions		 EXP Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein		 CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G EGR1 early growth response 1 multiple interactions
affects expression		 EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein		 CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 affects expression
multiple interactions		 EXP Ranolazine affects the expression of GATA4 protein
[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein		 CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G NAB1 NGFI-A binding protein 1 affects expression
multiple interactions		 EXP Ranolazine affects the expression of NAB1 protein
[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein		 CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression
multiple interactions		 EXP Ranolazine affects the expression of SLC8A1 protein
[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein		 CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 408
    role 408
      biological role 408
        biophysical role 73
          membrane transport modulator 71
            sodium channel modulator 7
              pyrethroid insecticide + 0
              sodium channel blocker + 7
              veratridine 0
paths to the root