CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: costunolide
Accession: CHEBI:3900
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Definition: A germacranolide with anthelminthic, antiparasitic and antiviral activities.
Synonyms: exact_synonym: (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one
related_synonym: (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one; (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3abeta,4,5,8,9,11aalpha-octahydrocyclodeca[b]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone; Costunlide; Costunolid; Costus lactone; Formula=C15H20O2; InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1; InChIKey=HRYLQFBHBWLLLL-AHNJNIBGSA-N; SMILES=C\\C1=C/CC\\C(C)=C\\[C@H]2OC(=O)C(=C)[C@@H]2CC1
alt_id: CHEBI:545296
xref: CAS:553-21-9; KEGG:C09382; KNApSAcK:C00003240
xref_mesh: MESH:C002602
xref: PMID:11534769; PMID:11912066; PMID:14510592; PMID:18409040; PMID:6476889; Patent:KR20000066932; Reaxys:14451; Wikipedia:Costunolide
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression
ISO
costunolide results in decreased expression of ABCB1 protein
CTD
PMID:37683593
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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Cat
catalase
increases activity
EXP
costunolide results in increased activity of CAT protein
CTD
PMID:20709041
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
G
Ctnnb1
catenin beta 1
increases expression
ISO
costunolide results in increased expression of CTNNB1 protein
CTD
PMID:37683593
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
G
Il10
interleukin 10
multiple interactions
ISO
costunolide inhibits the reaction [Ethanol results in decreased expression of IL10 protein]
CTD
PMID:26970604
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
G
Ins1
insulin 1
multiple interactions
EXP
costunolide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
CTD
PMID:19007766
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]
CTD
PMID:26970604
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
costunolide inhibits the reaction [Ethanol results in decreased expression of PCNA protein]
CTD
PMID:26970604
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
CTD
PMID:26970604
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
G
Tjp1
tight junction protein 1
increases expression
ISO
costunolide results in increased expression of TJP1 protein
CTD
PMID:37683593
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
G
Tnf
tumor necrosis factor
multiple interactions
ISO
costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:26970604
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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