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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkylbenzene
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Accession:CHEBI:38976 term browser browse the term
Definition:A monocyclic arene that is benzene substituted with one or more alkyl groups.
Synonyms:related_synonym: Alkylbenzol;   alkylbenzenes


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aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of AKT1 protein CTD PMID:30287338
G ANXA5 annexin A5 decreases expression EXP ochratoxin A results in decreased expression of ANXA5 mRNA CTD PMID:14994279 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression
EXP ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein
CTD PMID:28699257 PMID:30287338 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
affects expression
multiple interactions
EXP ochratoxin A results in decreased expression of BCL2 mRNA
ochratoxin A affects the expression of BCL2 mRNA
TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]
CTD PMID:28528741 PMID:29080797 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein
CTD PMID:30287338 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression EXP ochratoxin A results in increased expression of BRCA1 protein CTD PMID:32454083 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase decreases expression EXP ochratoxin A results in decreased expression of CAT protein CTD PMID:18547704 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CRYAB crystallin alpha B increases expression EXP ochratoxin A results in increased expression of CRYAB mRNA CTD PMID:14994279 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
JBrowse link
G CYP2G2 cytochrome P450 family 2 subfamily G member 2 decreases expression EXP ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:14994279 NCBI chr 6:49,069,613...49,084,953 JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP ochratoxin A results in decreased expression of DAD1 mRNA CTD PMID:14994279 NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192
JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]
CTD PMID:29080797 PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP ochratoxin A results in increased expression of DNMT3A mRNA CTD PMID:29080797 PMID:30923867 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]
CTD PMID:18547363 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GLMN glomulin, FKBP associated protein increases expression EXP ochratoxin A results in increased expression of GLMN mRNA CTD PMID:14994279 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GSTA1 mRNA
ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]
CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
increases expression
EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein
CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
decreases expression
EXP ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA
CTD PMID:14994279 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein CTD PMID:28699257 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP ochratoxin A results in decreased expression of HSPD1 mRNA CTD PMID:14994279 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP ochratoxin A results in decreased expression of ID2 mRNA CTD PMID:14994279 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP ochratoxin A results in increased expression of IGFBP2 mRNA CTD PMID:14994279 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 decreases secretion EXP ochratoxin A results in decreased secretion of IL2 protein CTD PMID:28699257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 increases expression EXP ochratoxin A results in increased expression of IL4 mRNA CTD PMID:14994279 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of IL6 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]
CTD PMID:28710020 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G LOC100522201 histone H2AX multiple interactions
increases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP ochratoxin A results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:28528741 PMID:28699257 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein
CTD PMID:28528741 PMID:28699257 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of MTOR protein CTD PMID:30287338 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NEIL1 nei like DNA glycosylase 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of NEIL1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
decreases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity
multiple interactions
decreases expression
EXP ochratoxin A results in decreased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased expression of NFE2L2 mRNA
CTD PMID:18547363 PMID:18547704 PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NPM1 nucleophosmin 1 increases expression EXP ochratoxin A results in increased expression of NPM1 mRNA CTD PMID:14994279 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of OGG1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions
EXP ochratoxin A results in increased cleavage of PARP1 protein
ochratoxin A results in increased expression of PARP1 protein
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
CTD PMID:30287338 PMID:32454083 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein CTD PMID:3753873 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP ochratoxin A results in decreased expression of PCNA protein CTD PMID:32454083 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression EXP ochratoxin A results in decreased expression of PFDN5 mRNA CTD PMID:14994279 NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877
JBrowse link
G PPIA peptidylprolyl isomerase A increases expression EXP ochratoxin A results in increased expression of PPIA mRNA CTD PMID:14994279 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP ochratoxin A results in decreased expression of PRDX1 mRNA CTD PMID:14994279 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
JBrowse link
G PTMA prothymosin alpha decreases expression EXP ochratoxin A results in decreased expression of PTMA mRNA CTD PMID:14994279 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435
JBrowse link
G RAD51 RAD51 recombinase increases expression EXP ochratoxin A results in increased expression of RAD51 protein CTD PMID:32454083 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,647...130,640,136
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:28528741 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RPA2 replication protein A2 increases expression EXP ochratoxin A results in increased expression of RPA2 protein CTD PMID:32454083 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916
JBrowse link
G RPS5 ribosomal protein S5 increases expression EXP ochratoxin A results in increased expression of RPS5 mRNA CTD PMID:14994279 NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]
CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP ochratoxin A results in decreased activity of SOD1 protein CTD PMID:18547704 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G SUMO1 small ubiquitin like modifier 1 decreases expression EXP ochratoxin A results in decreased expression of SUMO1 mRNA CTD PMID:14994279 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of TGFB1 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforaphane inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]
CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP ochratoxin A results in increased expression of TIMP2 mRNA CTD PMID:14994279 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TJP1 tight junction protein 1 affects localization EXP ochratoxin A affects the localization of TJP1 protein CTD PMID:14994279 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein
CTD PMID:28528741 PMID:28699257 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] CTD PMID:28710020 PMID:32454083 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G XPA XPA, DNA damage recognition and repair factor decreases expression EXP ochratoxin A results in decreased expression of XPA mRNA CTD PMID:14994279 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
JBrowse link
G XRCC1 X-ray repair cross complementing 1 increases expression EXP ochratoxin A results in increased expression of XRCC1 protein CTD PMID:32454083 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
JBrowse link
ochratoxin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity EXP ochratoxin B results in decreased activity of NFE2L2 protein CTD PMID:18547704 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
p-xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
multiple interactions
affects response to substance
EXP 4-xylene results in increased activity of CASP3 protein
aspartyl-glutamyl-valyl-aspartal inhibits the reaction [4-xylene results in increased activity of CASP3 protein]
CASP3 protein affects the susceptibility to 4-xylene
CTD PMID:14705839 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [4-xylene results in increased secretion of Malondialdehyde] CTD PMID:12781212 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases activity
multiple interactions
EXP 4-xylene results in increased activity of CYP2E1 protein
Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]
CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
toluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
affects response to substance
multiple interactions
EXP Toluene results in increased activity of CASP3 protein
CASP3 protein affects the susceptibility to Toluene
aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Toluene results in increased activity of CASP3 protein]
CTD PMID:14705839 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [Toluene results in increased secretion of Malondialdehyde] CTD PMID:12781212 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases activity
EXP Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 902
    role 861
      chemical role 645
        environmental contaminant 159
          benzene 63
            alkylbenzene 63
              (+/-)-threo-Anethole glycol 0
              (1-Ethylpropyl)benzene 0
              (1R)-2-(methylamino)-1-phenyl-1-propanol 0
              (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol 0
              (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol 0
              (2S,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)-2-butanol 0
              (2S,6R)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine 0
              1,3-Di-tert-butylbenzene 0
              1,4-Benzenedipropanol, alpha,alpha',gamma,gamma,gamma',gamma'-hexamethyl- 0
              1-(1-azepanyl)-2-(2-bromo-4-propan-2-ylphenoxy)ethanone 0
              1-(2,6-dimethyl-4-morpholinyl)-3-(4-propan-2-ylphenoxy)-2-propanol 0
              1-(3-methylphenyl)-3-(1-phenylpropylideneamino)thiourea 0
              1-(4-tert-butylphenoxy)-3-(1H-1,2,4-triazol-5-ylthio)-2-propanol 0
              1-(tert-butylamino)-3-(2-tert-butylphenoxy)-2-propanol 0
              1-Ethyl-3,5-diisopropyl-benzene 0
              1-Isopropyl-2-methylbenzene 0
              1-[1-(4-methoxyphenyl)propan-2-ylideneamino]-3-(4-propan-2-ylphenyl)thiourea 0
              1-[1-(4-tert-butylphenyl)ethylideneamino]-3-propan-2-ylthiourea 0
              1-[4-[2,4-bis(2-methylbutan-2-yl)phenoxy]butyl]-3-methylpyridin-1-ium 0
              1-[[5-(hydroxymethyl)-2-methyl-3-oxo-4-pyridinylidene]methylamino]-3-(4-propan-2-ylphenyl)thiourea 0
              1-butyl-3-[(2,5-dimethylphenyl)methylideneamino]thiourea 0
              1-isopentyl-2,3,4,6-tetramethylbenzene 0
              2,4-di-tert-butylphenol 0
              2,5-di-tert-butylphenol 0
              2,6-di-tert-butylphenol 0
              2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol 0
              2-(2-bromo-4-tert-butylphenoxy)-N-(2-furanylmethyl)acetamide 0
              2-(4-butan-2-ylanilino)-3-pyridinecarbonitrile 0
              2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol 0
              2-Methyl-2-phenyl-undecane 0
              2-[(2,4-dichlorophenyl)methylamino]-1-phenyl-1-propanol 0
              2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile 0
              2-[(dimethylamino)methyl]-4-methyl-6-(1-methylcyclohexyl)phenol 0
              2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-3-hydroxy-2-methylpropanenitrile 0
              2-[3-(2-cyanopropan-2-yl)-5-(hydroxymethyl)phenyl]-2-methylpropanenitrile 0
              2-[3-(2-cyanopropan-2-yl)-5-formylphenyl]-2-methylpropanenitrile 0
              2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol 0
              2-[[2-[[5-(4-tert-butylphenyl)-2-methoxycarbonyl-3-thiophenyl]amino]-2-oxoethyl]thio]acetic acid 0
              2-amino-1-(2-chlorophenyl)-1-propanol 0
              2-methyl-1-phenyl-2-propanyl hexanoate 0
              2-tert-Butylphenol 0
              3,4,5-Trimethoxyphenyl-2-propanone 0
              3,5-bis(2-cyanopropan-2-yl)benzoic acid 0
              3-(2,4,6-Trimethoxyphenyl)-2-butanone 0
              3-(3,5-ditert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal 0
              3-(3,5-ditert-butyl-4-hydroxyphenyl)-2-isocyano-2-propenenitrile 0
              3-(4-tert-butylphenoxy)-N-(4,5-dihydrothiazol-2-yl)propanamide 0
              3-tert-Butylphenol 0
              4,4a,5,6,7,8-Hexahydro-6-(p-hydroxyphenyl)-2(3H)-naphthalenone 0
              4,5-Bisphenol-o-quinone 0
              4-(3,5-Diphenylcyclohexyl)phenol 0
              4-(4-tert-butylphenoxy)-N-(4,5-dihydrothiazol-2-yl)butanamide 0
              4-(4-tert-butylphenyl)-4-hydroxybutanal 0
              4-Isopropyl-3-methylphenol 0
              4-Propylphenol 0
              4-[(1R)-1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol 0
              4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol 0
              4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol 0
              4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenol 0
              4-propylbenzoic acid 0
              4-sec-Butylphenol 0
              4-t-Butylbenzoic acid 0
              4-tert-Octylphenol 0
              5-phenyldodecane 0
              5-phenylundecane 0
              6-phenyldodecane 0
              6-phenylundecane 0
              AL-294 0
              AL-321 0
              Anisole, 2-isopropyl-4-methyl- 0
              Anisole, 4-sec-butyl 0
              Aramite 0
              Butacarb 0
              Buthiobate 0
              Crufomate 0
              Cumyluron 0
              DB-2073 0
              Dinex 0
              Ephedrine hydrochloride 0
              Erythrohydrobupropion 0
              Flurprimidol 0
              Isoxsuprine hydrochloride 0
              LSM-36830 0
              Malonoben 0
              N,N,O-Tridesmethyltramadol 0
              N,N-dimethylcarbamic acid [[1-amino-2-(4-tert-butylphenoxy)ethylidene]amino] ester 0
              N-(2-methoxycyclohexyl)-2,5-dimethylaniline 0
              N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide 0
              N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide 0
              N-[(4-tert-butylphenyl)methyl]-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine 0
              N-[3-[[diethylamino(sulfanylidene)methyl]thio]-1-oxopropyl]carbamic acid (4-propan-2-ylphenyl) ester 0
              N-[3-[[diethylamino(sulfanylidene)methyl]thio]-1-oxopropyl]carbamic acid (4-tert-butylphenyl) ester 0
              N-[5-(4-tert-butylphenyl)-1,3,4-thiadiazol-2-yl]-2-methoxyacetamide 0
              N-[[[2-(2-bromo-4-propan-2-ylphenoxy)-1-oxoethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide 0
              N3-[(4-tert-butylphenyl)methylideneamino]-1,2,4-triazole-3,4-diamine 0
              Nylidrin hydrochloride 0
              O-Desmethyltramadol 0
              Oxaziclomefone 0
              Phenol, 2,4-bis(1,1-dimethylethyl)-, phosphite (3:1) 0
              Phenylpropanolamine hydrochloride 0
              Promacyl 0
              Promecarb 0
              Terbucarb 0
              Valethamate bromide 0
              Xylometazoline 0
              bufeniode 0
              butamirate 0
              butetamate 0
              butylbenzene 0
              cumene + 0
              dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium 0
              dimethyl-[2-[2-[2-methyl-4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]-(phenylmethyl)ammonium 0
              dioxethedrin 0
              etafedrine 0
              ethylbenzene 0
              fenoxazoline 0
              fospropofol 0
              isoaminile 0
              isobutylbenzene 0
              lignin cw compound-292 0
              methylbenzene + 63
              oxeladin 0
              oxilofrine 0
              oxyfenamate 0
              p-Cymen-8-ol 0
              p-tert-Amylphenol 0
              p-tert-Butylbenzyl alcohol 0
              pentapiperium metilsulfate 0
              phenaglycodol 0
              propylbenzene + 0
              proxazole 0
              sec-butylbenzene + 0
              simetride 0
              tapentadol 0
              tinofedrine 0
              valethamate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 902
    subatomic particle 887
      composite particle 887
        hadron 887
          baryon 887
            nucleon 887
              atomic nucleus 887
                atom 887
                  main group element atom 856
                    main group molecular entity 854
                      s-block molecular entity 740
                        hydrogen molecular entity 726
                          hydrides 351
                            organic hydride 250
                              organic fundamental parent 250
                                hydrocarbon 186
                                  cyclic hydrocarbon 79
                                    monocyclic hydrocarbon 63
                                      annulene 63
                                        aromatic annulene 63
                                          benzene 63
                                            alkylbenzene 63
                                              (+/-)-threo-Anethole glycol 0
                                              (1-Ethylpropyl)benzene 0
                                              (1R)-2-(methylamino)-1-phenyl-1-propanol 0
                                              (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol 0
                                              (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol 0
                                              (2S,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)-2-butanol 0
                                              (2S,6R)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine 0
                                              1,3-Di-tert-butylbenzene 0
                                              1,4-Benzenedipropanol, alpha,alpha',gamma,gamma,gamma',gamma'-hexamethyl- 0
                                              1-(1-azepanyl)-2-(2-bromo-4-propan-2-ylphenoxy)ethanone 0
                                              1-(2,6-dimethyl-4-morpholinyl)-3-(4-propan-2-ylphenoxy)-2-propanol 0
                                              1-(3-methylphenyl)-3-(1-phenylpropylideneamino)thiourea 0
                                              1-(4-tert-butylphenoxy)-3-(1H-1,2,4-triazol-5-ylthio)-2-propanol 0
                                              1-(tert-butylamino)-3-(2-tert-butylphenoxy)-2-propanol 0
                                              1-Ethyl-3,5-diisopropyl-benzene 0
                                              1-Isopropyl-2-methylbenzene 0
                                              1-[1-(4-methoxyphenyl)propan-2-ylideneamino]-3-(4-propan-2-ylphenyl)thiourea 0
                                              1-[1-(4-tert-butylphenyl)ethylideneamino]-3-propan-2-ylthiourea 0
                                              1-[4-[2,4-bis(2-methylbutan-2-yl)phenoxy]butyl]-3-methylpyridin-1-ium 0
                                              1-[[5-(hydroxymethyl)-2-methyl-3-oxo-4-pyridinylidene]methylamino]-3-(4-propan-2-ylphenyl)thiourea 0
                                              1-butyl-3-[(2,5-dimethylphenyl)methylideneamino]thiourea 0
                                              1-isopentyl-2,3,4,6-tetramethylbenzene 0
                                              2,4-di-tert-butylphenol 0
                                              2,5-di-tert-butylphenol 0
                                              2,6-di-tert-butylphenol 0
                                              2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol 0
                                              2-(2-bromo-4-tert-butylphenoxy)-N-(2-furanylmethyl)acetamide 0
                                              2-(4-butan-2-ylanilino)-3-pyridinecarbonitrile 0
                                              2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol 0
                                              2-Methyl-2-phenyl-undecane 0
                                              2-[(2,4-dichlorophenyl)methylamino]-1-phenyl-1-propanol 0
                                              2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile 0
                                              2-[(dimethylamino)methyl]-4-methyl-6-(1-methylcyclohexyl)phenol 0
                                              2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-3-hydroxy-2-methylpropanenitrile 0
                                              2-[3-(2-cyanopropan-2-yl)-5-(hydroxymethyl)phenyl]-2-methylpropanenitrile 0
                                              2-[3-(2-cyanopropan-2-yl)-5-formylphenyl]-2-methylpropanenitrile 0
                                              2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol 0
                                              2-[[2-[[5-(4-tert-butylphenyl)-2-methoxycarbonyl-3-thiophenyl]amino]-2-oxoethyl]thio]acetic acid 0
                                              2-amino-1-(2-chlorophenyl)-1-propanol 0
                                              2-methyl-1-phenyl-2-propanyl hexanoate 0
                                              2-tert-Butylphenol 0
                                              3,4,5-Trimethoxyphenyl-2-propanone 0
                                              3,5-bis(2-cyanopropan-2-yl)benzoic acid 0
                                              3-(2,4,6-Trimethoxyphenyl)-2-butanone 0
                                              3-(3,5-ditert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal 0
                                              3-(3,5-ditert-butyl-4-hydroxyphenyl)-2-isocyano-2-propenenitrile 0
                                              3-(4-tert-butylphenoxy)-N-(4,5-dihydrothiazol-2-yl)propanamide 0
                                              3-tert-Butylphenol 0
                                              4,4a,5,6,7,8-Hexahydro-6-(p-hydroxyphenyl)-2(3H)-naphthalenone 0
                                              4,5-Bisphenol-o-quinone 0
                                              4-(3,5-Diphenylcyclohexyl)phenol 0
                                              4-(4-tert-butylphenoxy)-N-(4,5-dihydrothiazol-2-yl)butanamide 0
                                              4-(4-tert-butylphenyl)-4-hydroxybutanal 0
                                              4-Isopropyl-3-methylphenol 0
                                              4-Propylphenol 0
                                              4-[(1R)-1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol 0
                                              4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol 0
                                              4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol 0
                                              4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenol 0
                                              4-propylbenzoic acid 0
                                              4-sec-Butylphenol 0
                                              4-t-Butylbenzoic acid 0
                                              4-tert-Octylphenol 0
                                              5-phenyldodecane 0
                                              5-phenylundecane 0
                                              6-phenyldodecane 0
                                              6-phenylundecane 0
                                              AL-294 0
                                              AL-321 0
                                              Anisole, 2-isopropyl-4-methyl- 0
                                              Anisole, 4-sec-butyl 0
                                              Aramite 0
                                              Butacarb 0
                                              Buthiobate 0
                                              Crufomate 0
                                              Cumyluron 0
                                              DB-2073 0
                                              Dinex 0
                                              Ephedrine hydrochloride 0
                                              Erythrohydrobupropion 0
                                              Flurprimidol 0
                                              Isoxsuprine hydrochloride 0
                                              LSM-36830 0
                                              Malonoben 0
                                              N,N,O-Tridesmethyltramadol 0
                                              N,N-dimethylcarbamic acid [[1-amino-2-(4-tert-butylphenoxy)ethylidene]amino] ester 0
                                              N-(2-methoxycyclohexyl)-2,5-dimethylaniline 0
                                              N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide 0
                                              N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide 0
                                              N-[(4-tert-butylphenyl)methyl]-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine 0
                                              N-[3-[[diethylamino(sulfanylidene)methyl]thio]-1-oxopropyl]carbamic acid (4-propan-2-ylphenyl) ester 0
                                              N-[3-[[diethylamino(sulfanylidene)methyl]thio]-1-oxopropyl]carbamic acid (4-tert-butylphenyl) ester 0
                                              N-[5-(4-tert-butylphenyl)-1,3,4-thiadiazol-2-yl]-2-methoxyacetamide 0
                                              N-[[[2-(2-bromo-4-propan-2-ylphenoxy)-1-oxoethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide 0
                                              N3-[(4-tert-butylphenyl)methylideneamino]-1,2,4-triazole-3,4-diamine 0
                                              Nylidrin hydrochloride 0
                                              O-Desmethyltramadol 0
                                              Oxaziclomefone 0
                                              Phenol, 2,4-bis(1,1-dimethylethyl)-, phosphite (3:1) 0
                                              Phenylpropanolamine hydrochloride 0
                                              Promacyl 0
                                              Promecarb 0
                                              Terbucarb 0
                                              Valethamate bromide 0
                                              Xylometazoline 0
                                              bufeniode 0
                                              butamirate 0
                                              butetamate 0
                                              butylbenzene 0
                                              cumene + 0
                                              dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium 0
                                              dimethyl-[2-[2-[2-methyl-4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]-(phenylmethyl)ammonium 0
                                              dioxethedrin 0
                                              etafedrine 0
                                              ethylbenzene 0
                                              fenoxazoline 0
                                              fospropofol 0
                                              isoaminile 0
                                              isobutylbenzene 0
                                              lignin cw compound-292 0
                                              methylbenzene + 63
                                              oxeladin 0
                                              oxilofrine 0
                                              oxyfenamate 0
                                              p-Cymen-8-ol 0
                                              p-tert-Amylphenol 0
                                              p-tert-Butylbenzyl alcohol 0
                                              pentapiperium metilsulfate 0
                                              phenaglycodol 0
                                              propylbenzene + 0
                                              proxazole 0
                                              sec-butylbenzene + 0
                                              simetride 0
                                              tapentadol 0
                                              tinofedrine 0
                                              valethamate 0
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