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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indole alkaloid
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Accession:CHEBI:38958 term browser browse the term
Definition:An alkaloid containing an indole skeleton.
Synonyms:related_synonym: indole alkaloids
 alt_id: CHEBI:24795;   CHEBI:5901
 xref: KEGG:C06073;   Wikipedia:Indole_alkaloid



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2-methylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein] CTD PMID:15802305 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A multiple interactions ISO 2-methyl-5-HT binds to and results in increased activity of HTR3A protein CTD PMID:15802305 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15802305 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15802305 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
5-methoxy-N,N-diisopropyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion CTD PMID:26599973 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole CTD PMID:26599973 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone CTD PMID:26599973 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
5-methoxytryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
JBrowse link
G Kmo kynurenine 3-monooxygenase increases expression ISO 5-Methoxytryptamine results in increased expression of KMO mRNA CTD PMID:32243540 NCBI chr 1:175,459,759...175,488,419
Ensembl chr 1:175,447,947...175,489,682
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B decreases phosphorylation
increases phosphorylation
EXP 5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein
5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression ISO 5-Methoxytryptamine results in decreased expression of SOD2 mRNA CTD PMID:32243540 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Taar1 trace amine-associated receptor 1 increases activity
multiple interactions
EXP 5-Methoxytryptamine results in increased activity of TAAR1 protein
[5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367
JBrowse link
G Tph1 tryptophan hydroxylase 1 decreases expression ISO 5-Methoxytryptamine results in decreased expression of TPH1 mRNA CTD PMID:32243540 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
JBrowse link
6-hydroxymelatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult5a1 sulfotransferase family 5A, member 1 multiple interactions EXP Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin] CTD PMID:11181495 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054
JBrowse link
9-hydroxycanthin-6-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP3 protein CTD PMID:29225138 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein CTD PMID:29225138 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP9 protein CTD PMID:29225138 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL2 mRNA CTD PMID:29225138 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL5 mRNA CTD PMID:29225138 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
ajmalicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity
multiple interactions
ISO raubasine results in decreased activity of CYP2D6 protein
raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CTD PMID:15930738 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
ajmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Ajmaline results in decreased activity of KCNH2 protein CTD PMID:15599706 PMID:24052561 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity
affects response to substance
EXP
ISO
Ajmaline results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Ajmaline
CTD PMID:10662748 PMID:15520322 PMID:20174578 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
alcuronium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO WIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions ISO Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
alpha-ergocryptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergocryptine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
bromocriptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression
multiple interactions
ISO Bromocriptine results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]
CTD PMID:9111066 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases activity
increases expression
multiple interactions
ISO Bromocriptine results in increased activity of ABCB1B promoter
Bromocriptine results in increased expression of ABCB1B mRNA
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]
CTD PMID:9111066 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression
multiple interactions
ISO Bromocriptine results in increased expression of AKR1C3 mRNA
methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]
CTD PMID:21427058 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein CTD PMID:21867702 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO Bromocriptine results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein
CTD PMID:15046398 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bdnf brain derived neurotrophic factor decreases secretion EXP Bromocriptine results in decreased secretion of BDNF protein CTD PMID:12770616 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein CTD PMID:11786374 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]
Bromocriptine results in decreased expression of CYP11A1 protein
CTD PMID:12742521 PMID:21427058 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Bromocriptine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Bromocriptine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Dbh dopamine beta hydroxylase decreases activity ISO Bromocriptine results in decreased activity of DBH protein CTD PMID:501350 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
JBrowse link
G Drd2 dopamine receptor D2 affects expression
affects response to substance
multiple interactions
decreases expression
increases expression
increases response to substance
ISO
EXP
Bromocriptine affects the expression of DRD2 mRNA
DRD2 protein affects the susceptibility to Bromocriptine
Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]
Bromocriptine results in decreased expression of DRD2 mRNA
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Bromocriptine results in increased expression of DRD2 mRNA
DRD2 polymorphism results in increased susceptibility to Bromocriptine
CTD PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions
decreases expression
ISO [1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA
Bromocriptine results in decreased expression of DRD3 mRNA
CTD PMID:17000468 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions EXP [Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein CTD PMID:11786374 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Fshb follicle stimulating hormone beta increases expression ISO Bromocriptine results in increased expression of FSHB protein CTD PMID:86031 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gdnf glial cell line derived neurotrophic factor decreases expression
decreases secretion
EXP Bromocriptine results in decreased expression of GDNF mRNA
Bromocriptine results in decreased secretion of GDNF protein
CTD PMID:12770616 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
JBrowse link
G Gh growth hormone increases expression
decreases expression
ISO Bromocriptine results in increased expression of GH1 protein
Bromocriptine results in decreased expression of GH1 protein
CTD PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein CTD PMID:21867702 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
JBrowse link
G Ins2 insulin II decreases expression ISO Bromocriptine results in decreased expression of INS protein CTD PMID:16803851 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Lhb luteinizing hormone beta increases expression ISO Bromocriptine results in increased expression of LHB protein CTD PMID:86031 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein] CTD PMID:19595700 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein] CTD PMID:19595700 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases localization ISO Bromocriptine results in increased localization of NFE2L2 protein CTD PMID:21867702 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Ngf nerve growth factor increases secretion EXP Bromocriptine results in increased secretion of NGF protein CTD PMID:12770616 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein] CTD PMID:21867702 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA] CTD PMID:21427058 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein] CTD PMID:15677882 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pomc pro-opiomelanocortin-alpha decreases expression
increases expression
multiple interactions
ISO Bromocriptine results in decreased expression of POMC protein alternative form
Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]
CTD PMID:1325994 PMID:6274577 PMID:12742521 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization
ISO Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein]
Bromocriptine affects the localization of PRKCD protein
CTD PMID:19595700 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prl prolactin multiple interactions
decreases secretion
decreases expression
ISO
EXP
Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
Bromocriptine results in decreased secretion of PRL protein
Bromocriptine results in decreased expression of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]
CTD PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 More... NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA] CTD PMID:21427058 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein] CTD PMID:21867702 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Bromocriptine results in decreased expression of STAR protein CTD PMID:12742521 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat5a signal transducer and activator of transcription 5A affects localization EXP Bromocriptine affects the localization of STAT5A protein CTD PMID:17884938 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA] CTD PMID:1534540 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein] CTD PMID:15677882 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:11752888 PMID:21867702 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein] CTD PMID:15677882 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vip vasoactive intestinal polypeptide multiple interactions ISO Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]
CTD PMID:6441721 PMID:15677882 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
JBrowse link
brucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha fetoprotein multiple interactions ISO brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24060683 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Bax BCL2-associated X protein increases expression EXP
ISO
brucine results in increased expression of BAX protein CTD PMID:16443926 PMID:21684292 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO brucine results in decreased expression of BCL2 protein CTD PMID:16443926 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP3 protein
brucine results in increased expression of CASP3 protein
brucine results in increased expression of and results in increased activity of CASP3 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]
CTD PMID:16442763 PMID:16443926 PMID:17449162 PMID:21684292 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO brucine results in increased activity of and results in increased cleavage of CASP9 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [brucine results in increased activity of and results in increased cleavage of CASP9 protein]
[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP9 protein
CTD PMID:16443926 PMID:21684292 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO brucine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; brucine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:24060683 PMID:30027798 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions ISO brucine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM1 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; brucine promotes the reaction [Bethanechol binds to CHRM1 protein]; brucine promotes the reaction [Carbachol binds to CHRM1 protein]; brucine promotes the reaction [furtrethonium binds to CHRM1 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM1 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]] CTD PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:15294002 More... NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM2 protein]; brucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
brucine binds to CHRM2 protein
CTD PMID:9495826 PMID:10069518 PMID:15647330 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM3 protein]; brucine binds to and results in increased activity of CHRM3 protein mutant form; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM3 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Arecoline binds to CHRM3 protein]; brucine promotes the reaction [Bethanechol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; brucine promotes the reaction [furtrethonium binds to CHRM3 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM3 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
brucine binds to CHRM3 protein
CTD PMID:9224827 PMID:10069518 PMID:15647330 PMID:20466821 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]; brucine promotes the reaction [Bethanechol binds to CHRM4 protein]; brucine promotes the reaction [Carbachol binds to CHRM4 protein]; brucine promotes the reaction [furtrethonium binds to CHRM4 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM4 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; WIN 62577 inhibits the reaction [brucine binds to CHRM4 protein] CTD PMID:9224827 PMID:10069518 PMID:16709648 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
JBrowse link
G Ctsd cathepsin D decreases expression ISO
EXP
brucine results in decreased expression of CTSD mRNA
brucine results in decreased expression of CTSD mRNA; brucine results in decreased expression of CTSD protein
CTD PMID:23933019 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO brucine results in increased expression of CYP2B3 protein CTD PMID:8850324 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO brucine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
ISO [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein; [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein
brucine results in increased activity of CYP2E1 protein
CTD PMID:21800547 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases metabolic processing EXP CYP3A11 protein results in increased metabolism of brucine CTD PMID:31284022 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO
EXP
brucine results in decreased expression of FN1 mRNA
brucine results in decreased expression of FN1 mRNA; brucine results in decreased expression of FN1 protein
CTD PMID:23933019 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO brucine analog binds to and results in decreased activity of GLRA1 protein; brucine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 PMID:16687139 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP brucine results in increased expression of GPT protein CTD PMID:31284022 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO brucine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GPX1 protein] CTD PMID:30027798 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsr glutathione reductase multiple interactions ISO brucine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein] CTD PMID:30027798 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Lox lysyl oxidase decreases expression ISO
EXP
brucine results in decreased expression of LOX mRNA
brucine results in decreased expression of LOX mRNA; brucine results in decreased expression of LOX protein
CTD PMID:23933019 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
JBrowse link
G Mbp myelin basic protein affects expression ISO brucine affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO
EXP
brucine results in decreased expression of MMP2 mRNA
brucine results in decreased expression of MMP2 mRNA; brucine results in decreased expression of MMP2 protein
CTD PMID:23933019 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions EXP NPAS2 protein affects the metabolism of and affects the susceptibility to brucine CTD PMID:31284022 NCBI chr 1:39,233,013...39,402,321
Ensembl chr 1:39,232,812...39,402,317
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO brucine inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:24060683 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO brucine results in decreased expression of PTGS2 protein CTD PMID:16442763 PMID:17449162 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO brucine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of SOD1 protein] CTD PMID:30027798 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Tnf tumor necrosis factor decreases secretion EXP
ISO
brucine results in decreased secretion of TNF protein CTD PMID:21684292 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
caracurine VII term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2, cardiac affects binding ISO caracurine binds to CHRM2 protein CTD PMID:15647330 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding ISO caracurine binds to CHRM3 protein CTD PMID:15647330 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdc34 cell division cycle 34 decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr10:79,518,029...79,524,232
Ensembl chr10:79,518,029...79,524,232
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 2:132,658,061...132,686,117
Ensembl chr 2:132,658,061...132,686,117
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 2:181,405,099...181,469,579
Ensembl chr 2:181,405,125...181,469,590
JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162
JBrowse link
G Trp53 transformation related protein 53 increases expression
increases activity
ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442
JBrowse link
demethoxyfumitremorgin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of AKT1 protein CTD PMID:28359723 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bax BCL2-associated X protein increases expression ISO demethoxyfumitremorgin C results in increased expression of BAX protein CTD PMID:28359723 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2 protein CTD PMID:28359723 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2L1 protein CTD PMID:28359723 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP3 protein CTD PMID:28359723 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP8 protein CTD PMID:28359723 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP9 protein CTD PMID:28359723 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO demethoxyfumitremorgin C results in increased cleavage of PARP1 protein CTD PMID:28359723 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
dihydro-beta-erythroidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:12511591 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 6:64,706,109...64,708,229
Ensembl chr 6:64,706,109...64,708,229
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA] CTD PMID:23056257 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdk4 cyclin dependent kinase 4 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO dihydro-beta-erythroidine affects binding to Chrna2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr14:66,370,685...66,390,397
Ensembl chr14:66,372,488...66,390,397
JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 multiple interactions ISO Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
dihydro-beta-erythroidine affects binding [Epibatidine binds to Chrna3 protein]
CTD
RGD
PMID:9687574 PMID:16129735 PMID:15016836 RGD:2303195, RGD:2303194 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
CTD
RGD
PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 More... RGD:2303195, RGD:2303194 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 increases activity
multiple interactions
affects response to substance
ISO Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form
Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein
CTD PMID:10082212 PMID:19448648 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrnb2 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
RGD
PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 More... RGD:2303195, RGD:2303194 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
G Chrnb3 cholinergic receptor, nicotinic, beta polypeptide 3 multiple interactions ISO dihydro-beta-erythroidine affects binding to Chrnb3 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr 8:27,858,688...27,889,758
Ensembl chr 8:27,858,739...27,889,758
JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 affects binding
multiple interactions
ISO [CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:9687574 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein] CTD PMID:20457658 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA] CTD PMID:28555334 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA] CTD PMID:28555334 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein] CTD PMID:23999947 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA] CTD PMID:29981921 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA] CTD PMID:29981921 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
dihydroergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
ISO
EXP
Dihydroergotamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dihydroergotamine results in decreased activity of CYP1A1 protein
Dihydroergotamine results in increased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity EXP Dihydroergotamine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity EXP
ISO
Dihydroergotamine results in decreased activity of CYP2D22 protein
Dihydroergotamine results in decreased activity of CYP2D6 protein
CTD PMID:18420780 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity EXP Dihydroergotamine results in decreased activity of CYP3A11 protein CTD PMID:18420780 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Il24 interleukin 24 increases expression ISO Dihydroergotamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dihydroergotamine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
ellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]] CTD PMID:11577022 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Bax BCL2-associated X protein increases expression ISO ellipticine results in increased expression of BAX protein CTD PMID:16027529 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO ellipticine results in decreased expression of BCL2 protein CTD PMID:16027529 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO ellipticine results in decreased expression of and results in increased cleavage of BID protein CTD PMID:21843585 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]
ellipticine results in increased activity of CASP3 protein
CTD PMID:16027529 PMID:21843585 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP7 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] CTD PMID:21843585 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 multiple interactions ISO ellipticine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21843585 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO ellipticine results in increased activity of CASP9 protein
ellipticine results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:16027529 PMID:21843585 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO ellipticine results in decreased expression of CCNB1 protein
ellipticine results in increased expression of CCNB1 protein
CTD PMID:16027529 PMID:21843585 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ellipticine results in decreased expression of CCND1 protein CTD PMID:21843585 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO ellipticine results in decreased expression of CDC25C protein CTD PMID:16027529 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions ISO ellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein CTD PMID:16027529 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO ellipticine results in increased expression of CDKN1A protein
[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]
CTD PMID:29471073 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases expression ISO ellipticine results in decreased expression of CDKN1B protein CTD PMID:21843585 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
increases activity
multiple interactions
ISO
EXP
CYP1A1 protein results in increased metabolism of ellipticine
ellipticine results in increased expression of CYP1A1 protein
ellipticine results in increased activity of CYP1A1 protein
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; ellipticine inhibits the reaction [troglitazone results in increased activity of CYP1A1 protein]
ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
CTD PMID:17973980 PMID:18308446 PMID:18493746 PMID:21932800 PMID:22917556 More... NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD PMID:18493746 PMID:22917556 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
ISO
EXP
CYP1B1 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
CTD PMID:11577022 PMID:22917556 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing ISO CYP2C9 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases metabolic processing ISO CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form; FTL protein binds to and results in decreased uptake of ellipticine CTD PMID:30914192 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form
ellipticine results in increased expression of H2AX protein modified form
CTD PMID:30914192 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] CTD PMID:21843585 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] CTD PMID:21843585 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO ellipticine results in increased cleavage of PARP1 protein CTD PMID:21843585 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine CTD PMID:22390216 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
G Top2b topoisomerase (DNA) II beta decreases response to substance
increases response to substance
ISO TOP2B protein mutant form results in decreased susceptibility to ellipticine
TOP2B protein mutant form results in increased susceptibility to ellipticine
CTD PMID:15322234 PMID:16239602 NCBI chr14:6,038,976...6,104,585
Ensembl chr14:6,034,301...6,104,584
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
increases response to substance
ISO TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
ellipticine results in increased expression of TP53 protein
TP53 protein results in increased susceptibility to ellipticine
CTD PMID:29471073 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO ellipticine results in decreased expression of XIAP protein CTD PMID:16027529 PMID:21843585 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
ergocristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity
ISO ergocristine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ergocristine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Casp3 caspase 3 increases activity ISO ergocristine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
ergosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
ergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] CTD PMID:19121572 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Casp3 caspase 3 increases activity ISO Ergotamine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:19121572 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B multiple interactions ISO Ergotamine binds to and results in increased activity of HTR2B protein CTD PMID:11104741 NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692
JBrowse link
fumigaclavine C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression EXP fumigaclavine C results in decreased expression of IFNG mRNA; fumigaclavine C results in decreased expression of IFNG protein CTD PMID:16023606 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il12a interleukin 12a decreases expression EXP fumigaclavine C results in decreased expression of IL12A mRNA CTD PMID:16023606 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP fumigaclavine C results in decreased expression of IL1B mRNA CTD PMID:16023606 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 decreases expression EXP fumigaclavine C results in decreased expression of IL2 mRNA; fumigaclavine C results in decreased expression of IL2 protein CTD PMID:16023606 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression
EXP fumigaclavine C results in decreased activity of MMP9 protein
fumigaclavine C results in decreased expression of MMP9 mRNA
CTD PMID:16023606 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP fumigaclavine C results in decreased expression of TNF mRNA CTD PMID:16023606 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
Gelsemine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of gelsemine CTD PMID:34627953 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases expression
EXP Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein] CTD PMID:34627953 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP gelsemine results in increased expression of IL1B protein
Dexamethasone inhibits the reaction [gelsemine results in increased expression of IL1B protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein]
CTD PMID:34627953 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
gramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 multiple interactions ISO gramine binds to and results in increased activity of ADIPOR1 protein CTD PMID:23691032 NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases phosphorylation ISO gramine results in decreased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cdh1 cadherin 1 increases expression EXP Harmaline results in increased expression of CDH1 protein CTD PMID:35963316 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability
ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein
CTD PMID:22037238 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Eng endoglin decreases expression
multiple interactions
EXP Harmaline results in decreased expression of ENG mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA]
CTD PMID:35963316 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681
JBrowse link
G Ifng interferon gamma increases secretion EXP Harmaline results in increased secretion of IFNG protein CTD PMID:35963316 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il4 interleukin 4 multiple interactions
affects secretion
EXP Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein]
Harmaline affects the secretion of IL4 protein
CTD PMID:35963316 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions
decreases expression
EXP Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA] CTD PMID:35963316 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmaline results in decreased activity of MAOA protein CTD PMID:15178694 PMID:24373881 PMID:28302559 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression EXP Harmaline results in decreased expression of MKI67 protein CTD PMID:35963316 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Harmaline results in decreased expression of MMP2 protein CTD PMID:35963316 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP Harmaline results in decreased expression of PTGS2 mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA]
CTD PMID:35963316 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein
Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA]
CTD PMID:35963316 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression
ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA
CTD PMID:27590872 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity
ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein
CTD PMID:22037238 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO harman results in increased expression of CASP3 mRNA
harman results in increased cleavage of CASP3 protein
CTD PMID:35985368 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 increases expression ISO harman results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp9 caspase 9 increases expression ISO harman results in increased expression of CASP9 mRNA CTD PMID:35985368 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase decreases activity ISO harman results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein
CTD PMID:20732341 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO harman results in increased expression of HMOX1 mRNA CTD PMID:35985368 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO harman results in increased expression of NFE2L2 protein CTD PMID:35985368 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO harman results in increased expression of NQO1 mRNA CTD PMID:35985368 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO harman results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions
decreases activity
ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein
CTD PMID:30189235 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions
decreases activity
ISO harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A2 protein
CTD PMID:30189235 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Taar1 trace amine-associated receptor 1 increases activity
multiple interactions
EXP harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367
JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Harmine results in decreased activity of ACHE protein CTD PMID:34078836 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions EXP Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Axin2 axin 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta decreases expression ISO harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases phosphorylation ISO Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 increases phosphorylation
multiple interactions
EXP Harmine results in increased phosphorylation of CHD4 protein
AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]
CTD PMID:27805061 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions
increases expression
EXP Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein
CTD PMID:27805061 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855
JBrowse link
G Cox8b cytochrome c oxidase subunit 8B increases expression EXP Harmine results in increased expression of COX8B protein CTD PMID:27805061 NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein
CTD PMID:22001777 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases expression EXP Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812
JBrowse link
G Dyrk1a dual-specificity tyrosine phosphorylation regulated kinase 1a multiple interactions
decreases expression
affects binding
decreases activity
ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein
CTD
RGD
PMID:21573099 PMID:25751815 PMID:26067684 RGD:11097969 NCBI chr16:94,370,770...94,496,378
Ensembl chr16:94,370,869...94,496,376
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368
JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr10:110,580,799...110,623,245
Ensembl chr10:110,581,300...110,623,245
JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Ins1 insulin I multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ins2 insulin II increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Lepr leptin receptor multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Mafa MAF bZIP transcription factor A increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmine results in decreased activity of MAOA protein CTD PMID:24373881 PMID:28302559 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286
JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577
JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658
JBrowse link
G Pln phospholamban increases expression ISO harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression
EXP [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein
CTD PMID:20519739 PMID:27805061 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
EXP Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]
Harmine results in increased expression of PPARGC1A protein
CTD PMID:27805061 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prdm16 PR domain containing 16 increases expression
multiple interactions
EXP Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]
CTD PMID:27805061 NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]
Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
CTD PMID:27805061 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
JBrowse link
harmol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP harmol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity
EXP
ISO
harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
harmol results in decreased stability of CYP1A1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [harmol results in decreased stability of CYP1A1 protein]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
harmol results in decreased activity of CYP1A1 protein
CTD PMID:22001777 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 multiple interactions EXP Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol] CTD PMID:11181495 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054
JBrowse link
ibogaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769 PMID:24307198 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity ISO Ibogaine results in decreased activity of SCN5A protein CTD PMID:23707769 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases response to substance ISO SEC24D protein results in increased susceptibility to Ibogaine CTD PMID:27555326 NCBI chr 3:123,058,451...123,159,290
Ensembl chr 3:123,061,104...123,159,290
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
increases expression
ISO Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein
CTD PMID:27555326 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium channel, voltage-gated, type V, alpha multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
lisuride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
JBrowse link
G Ifng interferon gamma increases expression ISO Lisuride results in increased expression of IFNG CTD PMID:7948314 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Prl prolactin multiple interactions
decreases secretion
ISO Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein
Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein
CTD PMID:386688 PMID:6492995 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
luzindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein] CTD PMID:23554006 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Gast gastrin multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
JBrowse link
G Gsr glutathione reductase multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein] CTD PMID:23554006 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G H19 H19, imprinted maternally expressed transcript multiple interactions EXP luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of H19 RNA in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog multiple interactions EXP luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Kras protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Mir675 microRNA 675 multiple interactions EXP luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of Mir675 RNA in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 7:142,130,801...142,130,884
Ensembl chr 7:142,130,801...142,130,884
JBrowse link
G Mtnr1a melatonin receptor 1A multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein] CTD PMID:28238930 NCBI chr 8:45,522,144...45,542,270
Ensembl chr 8:45,522,174...45,541,543
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions EXP
ISO
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B protein
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
CTD PMID:11270484 PMID:21473625 PMID:28238930 NCBI chr 9:15,773,910...15,785,852
Ensembl chr 9:15,735,824...15,785,852
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]] CTD PMID:26283214 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PPARG protein] CTD PMID:29734669 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]] CTD PMID:25159133 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prnp prion protein multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]] CTD PMID:26283214 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein] CTD PMID:23554006 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein] CTD PMID:23554006 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] CTD PMID:26283214 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Trp53 protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Usp10 ubiquitin specific peptidase 10 multiple interactions EXP luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Usp10 protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 8:120,637,099...120,684,299
Ensembl chr 8:120,637,099...120,684,299
JBrowse link
lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding ISO LSD binds to Drd2 protein RGD PMID:15852061 RGD:1581406 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B multiple interactions
affects binding
ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797 PMID:29458138 NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692
JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881
JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein] CTD PMID:28223141 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb6 ATP-binding cassette, sub-family B member 6 multiple interactions
decreases metabolic processing
EXP [ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
ABCB6 gene mutant form results in decreased metabolism of Melatonin
CTD PMID:25623066 NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACADM mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
JBrowse link
G Acan aggrecan increases expression ISO Melatonin results in increased expression of ACAN mRNA CTD PMID:20738756 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACAT1 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ACE2 protein] CTD PMID:35844137 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of ACHE]; Melatonin inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Melatonin inhibits the reaction [Dexamethasone results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]] CTD PMID:19705549 PMID:21986892 PMID:22013727 PMID:30372842 PMID:35526705 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]] CTD PMID:35093381 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM2 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 7:119,153,563...119,199,917
Ensembl chr 7:119,153,563...119,199,913
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 multiple interactions EXP Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM3 mRNA] CTD PMID:35367536 NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:26882442 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Melatonin results in decreased expression of ADIPOQ mRNA CTD PMID:20738756 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Adora2b adenosine A2b receptor multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
Melatonin results in decreased expression of ADORA2B mRNA
CTD PMID:21461237 NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of AGER protein] CTD PMID:29763682 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of AGT protein
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]
CTD PMID:19018803 PMID:35844137 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IBA1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of AIF1 protein] CTD PMID:34673010 PMID:36566971 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Aim2 absent in melanoma 2 decreases expression
multiple interactions
EXP Melatonin results in decreased expression of AIM2 mRNA
Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of AIM2 mRNA]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel inhibits the reaction [Melatonin results in decreased expression of AIM2 mRNA]
CTD PMID:36504304 NCBI chr 1:173,177,105...173,293,606
Ensembl chr 1:173,178,445...173,293,606
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO
EXP
Melatonin results in increased phosphorylation of AKT1 protein
Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]
CTD PMID:18078454 PMID:21138475 PMID:22225513 PMID:23374533 PMID:23963992 More... NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alas1 aminolevulinic acid synthase 1 multiple interactions EXP Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein] CTD PMID:24523661 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
JBrowse link
G Alb albumin multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in decreased expression of ALB protein] CTD PMID:16652224 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA] CTD PMID:23963992 NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases expression
multiple interactions
ISO Melatonin results in increased expression of ALPL mRNA
Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of ALPL protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]
CTD PMID:20738756 PMID:31809235 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G Amh anti-Mullerian hormone multiple interactions
increases expression
ISO bisphenol A inhibits the reaction [Melatonin results in increased expression of AMH mRNA] CTD PMID:33967032 NCBI chr10:80,641,074...80,643,513
Ensembl chr10:80,641,077...80,643,482
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA] CTD PMID:31330490 NCBI chr 1:58,068,963...58,145,569
Ensembl chr 1:58,069,090...58,145,572
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression
ISO
EXP
Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form]
Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]]
Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of APP protein
CTD PMID:10617124 PMID:18231852 PMID:18537544 PMID:33130240 PMID:35526705 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO [Melatonin co-treated with Ethanol] results in increased expression of AR protein; Ethanol inhibits the reaction [Melatonin results in increased expression of AR protein] CTD PMID:23591044 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Arg1 arginase, liver multiple interactions ISO Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of ARG1 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of ARG1 protein] CTD PMID:36566971 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of ARNT mRNA] CTD PMID:33962019 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
JBrowse link
G Astl astacin like metalloendopeptidase multiple interactions EXP Melatonin inhibits the reaction [bisphenol A results in decreased expression of and affects the localization of ASTL protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of and affects the localization of ASTL protein] CTD PMID:28178360 PMID:31931096 NCBI chr 2:127,180,559...127,199,575
Ensembl chr 2:127,180,559...127,199,571
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein] CTD PMID:23591579 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP
Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of ATF4 protein]
CTD PMID:17645694 PMID:25259610 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of ATF6 protein]
CTD PMID:18715270 PMID:25259610 PMID:28070110 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA] CTD PMID:35568058 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]] CTD PMID:35568058 PMID:36421005 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of ATM protein] CTD PMID:35643323 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr15:38,662,096...38,692,688
Ensembl chr15:38,662,177...38,692,690
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions ISO Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of BACE1 protein] CTD PMID:33130240 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation
ISO
EXP
Melatonin promotes the reaction [YWHAB protein binds to BAD protein]
Melatonin results in increased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased phosphorylation of BAD protein]
CTD PMID:18078454 PMID:21138475 PMID:29763682 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO
EXP
[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]
CTD PMID:10965999 PMID:19220725 PMID:23963992 PMID:33962019 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of BAX protein
Melatonin results in increased expression of BAX mRNA
Melatonin inhibits the reaction [Cisplatin results in increased cleavage of BAX protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
Melatonin results in increased expression of BAX protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]
[Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein
Melatonin results in increased expression of BAX mRNA; Melatonin results in increased expression of BAX protein
CTD PMID:9649124 PMID:10965999 PMID:14690559 PMID:15683462 PMID:15964511 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BBC3 mRNA]
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BBC3 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of BBC3 protein]
CTD PMID:25259610 PMID:33962019 PMID:35643323 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
increases expression
affects localization
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]
Melatonin results in decreased expression of BCL2 mRNA; Melatonin results in decreased expression of BCL2 protein
[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]
Melatonin results in increased expression of BCL2 protein
Melatonin affects the localization of BCL2 protein
CTD PMID:9649124 PMID:10965999 PMID:12220328 PMID:14690559 PMID:14993511 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2L1 mRNA]
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]
CTD PMID:19220725 PMID:21244482 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BCL2L11 mRNA] CTD PMID:35643323 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Bcl2l15 BCLl2-like 15 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BCL2L15 mRNA] CTD PMID:33962019 NCBI chr 3:103,738,331...103,761,934
Ensembl chr 3:103,739,917...103,761,934
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of BDH2 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 3:134,986,982...135,010,187
Ensembl chr 3:134,986,982...135,010,187
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP
ISO
Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]; Melatonin inhibits the reaction [Dietary Fats results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of BDNF mRNA]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]
CTD PMID:29476728 PMID:30372842 PMID:35526705 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO
EXP
Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]
CTD PMID:24799992 PMID:35568058 PMID:36421005 PMID:37277016 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions
ISO Melatonin results in increased expression of BGLAP mRNA
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of BGLAP mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased secretion of BGLAP protein]
CTD PMID:20738756 PMID:31809235 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BID mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]
Melatonin results in increased expression of BID protein
CTD PMID:19552762 PMID:33962019 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of BIRC5 mRNA
[Doxorubicin co-treated with Melatonin] results in decreased expression of BIRC5 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BIRC5 mRNA]
CTD PMID:33507000 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 multiple interactions ISO Melatonin affects the reaction [Rotenone affects the expression of BMAL1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of BMAL1] CTD PMID:23085516 PMID:25430725 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333
JBrowse link
G Bmi1 Bmi1 polycomb ring finger oncogene multiple interactions
increases expression
ISO Melatonin affects the reaction [Rotenone affects the phosphorylation of BMI1 protein]
Melatonin results in increased expression of BMI1 mRNA
CTD PMID:33157086 NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions
increases expression
ISO
EXP
[PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3 mRNA]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]
CTD PMID:31330490 PMID:33962019 PMID:37028639 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3L mRNA] CTD PMID:33962019 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Ethanol results in increased expression of BTG2 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA] CTD PMID:28095641 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions EXP Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CALCA protein]] CTD PMID:34146326 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073
JBrowse link
G Capn1 calpain 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CAPN1 mRNA]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of CAPN1 protein]
CTD PMID:25259610 PMID:30372842 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO
[SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of CASP1 mRNA]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP1 protein
CTD PMID:23963992 PMID:25903262 PMID:36504304 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Melatonin co-treated with Aluminum Chloride] results in decreased expression of CASP12 protein; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein]
Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]
CTD PMID:17645694 PMID:18715270 PMID:28070110 PMID:30910607 PMID:33130240 More... NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
decreases expression
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in increased expression of CASP3 protein; [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP3 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein]
Melatonin results in increased expression of CASP3 protein
Melatonin results in decreased activity of CASP3 protein
Melatonin results in increased activity of CASP3 protein
Melatonin results in decreased expression of CASP3 protein
[Melatonin co-treated with Thioacetamide] results in increased expression of CASP3 protein; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of and results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]]
Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Radon results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]
CTD PMID:12220328 PMID:12880480 PMID:15683462 PMID:15800915 PMID:15964511 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO
EXP
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP8 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]
Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]
Melatonin results in increased activity of CASP8 protein
CTD PMID:19012662 PMID:21431366 PMID:25259610 PMID:25454643 PMID:33962019 More... NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP9 protein modified form]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]
Melatonin results in increased activity of CASP9 protein
Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]
CTD PMID:19012662 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20964710 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
decreases activity
EXP
ISO
[aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein]
Melatonin results in increased expression of CAT mRNA
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
Melatonin results in decreased activity of CAT protein
[aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:9194422 PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cck cholecystokinin increases secretion ISO Melatonin results in increased secretion of CCK protein CTD PMID:15009505 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22225513 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA]
CTD PMID:22225513 PMID:31330490 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL9 mRNA] CTD PMID:22225513 NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462
JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of CCNB1 mRNA; Melatonin results in decreased expression of CCNB1 protein
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of CCNB1 protein]
CTD PMID:21108658 PMID:35643323 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Melatonin results in decreased expression of CCND1 mRNA; Melatonin results in decreased expression of CCND1 protein CTD PMID:21108658 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions EXP Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 protein] CTD PMID:36265525 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
JBrowse link
G Cd14 CD14 antigen multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CD14 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd200 CD200 molecule decreases expression EXP Melatonin results in decreased expression of CD200 protein CTD PMID:27503577 NCBI chr16:45,202,474...45,229,419
Ensembl chr16:45,202,498...45,229,416
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CD36 mRNA] CTD PMID:21689150 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of CDK1 mRNA; Melatonin results in decreased expression of CDK1 protein
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK1 protein]
CTD PMID:21108658 PMID:35643323 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK2 protein] CTD PMID:23963992 PMID:35643323 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO Melatonin results in decreased expression of CDK4 mRNA; Melatonin results in decreased expression of CDK4 protein CTD PMID:21108658 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Melatonin results in increased expression of CDKN1A protein
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Melatonin inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
CTD PMID:12071473 PMID:18384530 PMID:29330934 PMID:29734669 PMID:33962019 More... NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1B mRNA] CTD PMID:33962019 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO
EXP
CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CEBPB protein]
CTD PMID:34973135 PMID:38008054 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]
Melatonin results in decreased expression of CISH mRNA
CTD PMID:21461237 NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
JBrowse link
G Ckb creatine kinase, brain multiple interactions ISO Melatonin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CKB protein] CTD PMID:19389042 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Clec4a3 C-type lectin domain family 4, member a3 multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC4A3 mRNA]
Melatonin results in increased expression of CLEC4A3 mRNA
CTD PMID:21461237 NCBI chr 6:122,929,474...122,946,837
Ensembl chr 6:122,929,474...122,946,834
JBrowse link
G Clec4n C-type lectin domain family 4, member n multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC4N mRNA]
Melatonin results in decreased expression of CLEC4N mRNA
CTD PMID:21461237 NCBI chr 6:123,206,802...123,223,983
Ensembl chr 6:123,206,802...123,223,980
JBrowse link
G Clock clock circadian regulator multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Melatonin inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA] CTD PMID:38000455 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Colec12 collectin sub-family member 12 multiple interactions EXP [Lipopolysaccharides co-treated with Melatonin] results in increased expression of COLEC12 mRNA CTD PMID:21461237 NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions EXP Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein] CTD PMID:30910607 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946
JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA] CTD PMID:23963992 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Cry1 cryptochrome circadian regulator 1 multiple interactions ISO Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]; Melatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA] CTD PMID:23085516 PMID:25430725 NCBI chr10:84,967,564...85,020,918
Ensembl chr10:84,967,564...85,020,928
JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression
multiple interactions
ISO Melatonin affects the expression of CRY2 mRNA
Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]; Melatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]
CTD PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr 2:92,233,991...92,264,426
Ensembl chr 2:92,233,991...92,264,388
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]
Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of CTNNB1 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CTNNB1 protein]
CTD PMID:26990689 PMID:31809235 PMID:35526705 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein] CTD PMID:21392095 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Ctsd cathepsin D multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CXCL10 mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
Melatonin results in decreased expression of CXCL10 mRNA
CTD PMID:21461237 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA]
[SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]
Melatonin results in decreased expression of CYBB mRNA
Melatonin inhibits the reaction [Galactose results in increased expression of CYBB protein]
CTD PMID:31330490 PMID:34673010 PMID:36504304 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CYCS mRNA]
Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]
CTD PMID:33962019 PMID:36421005 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
decreases activity
ISO Melatonin results in decreased expression of CYP19A1
Melatonin results in decreased activity of CYP19A1 protein
CTD PMID:16080194 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA]
Melatonin results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of Melatonin
CTD PMID:15616152 PMID:19919601 PMID:20033131 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
increases hydroxylation
affects metabolic processing
decreases activity
ISO
EXP
CYP1A2 protein results in decreased methylation of Melatonin
[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
CYP1A2 protein results in increased hydroxylation of Melatonin
CYP1A2 protein affects the metabolism of Melatonin
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA
Melatonin results in decreased activity of CYP1A2 protein
Melatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]
CTD PMID:15616152 PMID:15626586 PMID:15824912 PMID:17565714 PMID:19919601 More... NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
ISO 2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin]
Melatonin results in decreased activity of CYP1B1 protein
CTD PMID:15616152 PMID:19919601 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:28095641 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases methylation
increases hydroxylation
ISO CYP2C19 protein results in decreased methylation of Melatonin
CYP2C19 protein results in increased hydroxylation of Melatonin
CTD PMID:15616152 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:20338863 PMID:20964710 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]]; Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CYP3A11 mRNA] CTD PMID:15617534 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Melatonin results in decreased expression of CYP7A1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]
CTD PMID:28095641 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:28095641 NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
JBrowse link
G Dap3 death associated protein 3 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 3:88,828,110...88,858,504
Ensembl chr 3:88,828,110...88,858,488
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions ISO Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH1 protein] CTD PMID:36890697 NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032
JBrowse link
G Ddah2 DDAH family member 2, ADMA independent multiple interactions ISO Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH2 protein] CTD PMID:36890697 NCBI chr17:35,278,011...35,281,075
Ensembl chr17:35,278,011...35,281,071
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of DDIT3 protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of DDIT3 protein]
CTD PMID:18715270 PMID:25259610 PMID:28070110 PMID:33130240 PMID:34673010 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions
increases expression
ISO [Doxorubicin co-treated with Melatonin] results in increased expression of DIABLO protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of DIABLO mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DIABLO mRNA]
Melatonin results in increased expression of DIABLO mRNA; Melatonin results in increased expression of DIABLO protein
CTD PMID:33507000 PMID:33962019 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of DNM1L protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DNM1L mRNA]; Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]
CTD PMID:26882442 PMID:29183837 PMID:29966675 PMID:33962019 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
JBrowse link
G Dnm2 dynamin 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 9:21,336,167...21,419,055
Ensembl chr 9:21,336,204...21,419,055
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] CTD PMID:24969583 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]
Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of E2F1 protein] CTD PMID:23963992 PMID:25259610 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ECHS1 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 PMID:34673010 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:28070110 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:19054297 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 7:110,667,192...110,682,237
Ensembl chr 7:110,666,957...110,682,237
JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847
JBrowse link
G Eno2 enolase 2, gamma neuronal multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] CTD PMID:24969583 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 increases expression ISO Melatonin results in increased expression of ERCC1 protein CTD PMID:24799992 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]; Melatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein] CTD PMID:20136702 PMID:28070110 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]
Melatonin results in decreased expression of ESR1 mRNA
Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein
[Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA]
CTD PMID:15813899 PMID:16030176 PMID:16051031 PMID:16635015 PMID:23591044 More... NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
decreases expression
ISO [Melatonin co-treated with Ethanol] results in increased expression of ESR2 protein; Ethanol inhibits the reaction [Melatonin results in decreased expression of ESR2 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of ESR2 protein] CTD PMID:23591044 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression ISO Melatonin results in decreased expression of FABP4 mRNA CTD PMID:20738756 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]
Melatonin results in decreased expression of FAS mRNA; Melatonin results in decreased expression of FAS protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of FAS protein]
CTD PMID:14993511 PMID:20181888 PMID:23963992 PMID:25259610 PMID:25454643 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand multiple interactions ISO
EXP
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of FASL protein]
CTD PMID:14993511 PMID:25259610 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FASN mRNA] CTD PMID:21689150 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA]
Melatonin results in decreased expression of FCGR2B mRNA
CTD PMID:21461237 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]; Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein] CTD PMID:19476551 NCBI chr14:58,308,543...58,350,311
Ensembl chr14:58,308,004...58,350,177
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of FIS1 mRNA]
CTD PMID:29966675 PMID:33962019 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Melatonin inhibits the reaction [Capsaicin results in increased expression of FOS protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of FOS protein] CTD PMID:19172228 PMID:28238930 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in decreased expression of FSHB protein] CTD PMID:23591044 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]] CTD PMID:35093381 NCBI chr  X:17,386,206...17,438,600
Ensembl chr  X:17,422,803...17,438,564
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
multiple interactions
ISO
EXP
Melatonin results in increased activity of G6PD protein
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of G6PD protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein
CTD PMID:16224550 PMID:25903262 PMID:29763682 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein] CTD PMID:19409439 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014
JBrowse link
G Gast gastrin multiple interactions
increases expression
ISO luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 PMID:16207293 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO
EXP
Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GFAP protein]
Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]
CTD PMID:17572393 PMID:25288107 PMID:34673010 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:15700767 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Melatonin inhibits the reaction [Glucose results in increased expression of GLB1 protein] CTD PMID:38000455 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Melatonin promotes the reaction [bisphenol A results in increased expression of GNRH1 mRNA] CTD PMID:33967032 NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions
increases expression
ISO [bisphenol A co-treated with Melatonin] results in increased expression of GNRHR mRNA
Melatonin results in increased expression of GNRHR mRNA
CTD PMID:33967032 NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO [Melatonin co-treated with Thioacetamide] results in increased expression of GPT protein; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:15700767 PMID:26882442 PMID:31967703 PMID:36890697 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO
EXP
[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]
Melatonin results in increased expression of GPX1 mRNA
CTD PMID:15589378 PMID:25288107 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]] CTD PMID:35093381 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased expression of GRIN1 protein] CTD PMID:34673010 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased expression of GRIN2B protein] CTD PMID:34673010 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of GSK3B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]
CTD PMID:15842767 PMID:31809235 PMID:35526705 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions
increases activity
decreases expression
ISO
EXP
[Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; aluminum lactate affects the reaction [Melatonin results in increased activity of GSR protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased activity of GSR protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of GSR protein
Melatonin results in decreased expression of GSR protein
[aluminum lactate co-treated with Melatonin] results in increased expression of GSR mRNA; aluminum lactate promotes the reaction [Melatonin results in decreased expression of GSR protein]; luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased expression of GSR protein]
Melatonin results in decreased expression of GSR mRNA
CTD PMID:12823611 PMID:16098089 PMID:16224550 PMID:16931443 PMID:19405147 More... NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions ISO [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:20033131 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA CTD PMID:20033131 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]
Melatonin affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA]
CTD PMID:21986892 PMID:23963992 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G H19 H19, imprinted maternally expressed transcript increases expression ISO monocrotaline increases expression of H19 RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917
JBrowse link
G H2ax H2A.X variant histone multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of HAVCR1 protein] CTD PMID:29763682 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity
multiple interactions
ISO Melatonin results in decreased activity of HDAC3 protein
CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
CTD PMID:34973135 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA] CTD PMID:33962019 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [decabromobiphenyl ether affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein]
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMGB1 mRNA]
CTD PMID:27413111 PMID:35844137 PMID:36566971 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO
EXP
Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of HMOX1 mRNA]]
Melatonin results in increased expression of HMOX1 protein
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
Melatonin results in decreased expression of HMOX1 mRNA
CTD PMID:10942521 PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
decreases expression
ISO [Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]
Melatonin results in decreased expression of HMOX2 mRNA
CTD PMID:21442002 PMID:21986892 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606
JBrowse link
G Hsf1 heat shock factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:23963992 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA] CTD PMID:31330490 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of HSPA5 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:20136702 PMID:28070110 PMID:33130240 PMID:34673010 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa9 heat shock protein 9 multiple interactions ISO Melatonin affects the reaction [Mercuric Chloride results in increased expression of HSPA9 protein] CTD PMID:16801527 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IFNG protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]
CTD PMID:16373423 PMID:23374533 PMID:23963992 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression ISO melatonin decreases expression of Igf1r RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO
[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL10 protein]; IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 protein]
Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of IL10 protein]
CTD PMID:16373423 PMID:36566971 PMID:37269891 PMID:37598416 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il11 interleukin 11 multiple interactions EXP Melatonin inhibits the reaction [Dextran Sulfate results in decreased expression of IL11 protein] CTD PMID:36265525 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il13 interleukin 13 multiple interactions EXP Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]] CTD PMID:34146326 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il17a interleukin 17A multiple interactions EXP IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A protein]] CTD PMID:34146326 PMID:37269891 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of IL18 mRNA] CTD PMID:36504304 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1A protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]
Melatonin results in decreased expression of IL1A mRNA
CTD PMID:21461237 PMID:36265525 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
EXP
ISO
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL1B protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Nickel results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]
Melatonin results in decreased secretion of IL1B protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]]
Melatonin results in decreased expression of IL1B mRNA; Melatonin results in decreased expression of IL1B protein
CTD PMID:15714805 PMID:16373423 PMID:19028472 PMID:20374443 PMID:21461237 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 increases activity
multiple interactions
ISO
EXP
Melatonin results in increased activity of IL2 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL2 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]
CTD PMID:9730580 PMID:16373423 PMID:36421005 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:36265525 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:34146326 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il5 interleukin 5 multiple interactions EXP Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 protein]] CTD PMID:34146326 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
ISO
EXP
Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 protein]
Melatonin results in decreased secretion of IL6 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL6 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]
CTD PMID:16373423 PMID:20374443 PMID:21158907 PMID:27413111 PMID:28238930 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il7 interleukin 7 multiple interactions EXP Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]] CTD PMID:36421005 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Ins1 insulin I multiple interactions ISO Melatonin affects the reaction [Streptozocin results in decreased expression of INS1 protein]; Melatonin inhibits the reaction [Colforsin results in increased secretion of INS1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]] CTD PMID:12153439 PMID:17198541 PMID:32554039 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Insr insulin receptor multiple interactions ISO Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:19705549 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
JBrowse link
G Itpr3 inositol 1,4,5-triphosphate receptor 3 multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased expression of ITPR3 protein] CTD PMID:34673010 NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197
JBrowse link
G Izumo1r IZUMO1 receptor, JUNO multiple interactions EXP Melatonin inhibits the reaction [bisphenol A affects the expression of and affects the localization of IZUMO1R protein]; Melatonin inhibits the reaction [Ethinyl Estradiol affects the localization of IZUMO1R protein] CTD PMID:28178360 PMID:31931096 NCBI chr 9:14,797,110...14,815,247
Ensembl chr 9:14,797,110...14,815,245
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of JUN protein] CTD PMID:28238930 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of KDR mRNA] CTD PMID:33962019 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression
multiple interactions
EXP Melatonin results in decreased expression of KEAP1 protein
Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]
CTD PMID:25288107 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Kl klotho multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of LAMP2 protein] CTD PMID:26882442 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331
JBrowse link
G Lep leptin decreases expression ISO Melatonin results in decreased expression of LEP mRNA
Melatonin results in decreased expression of LEP protein
CTD PMID:19028472 PMID:20738756 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO [Melatonin co-treated with LHB protein] results in increased chemical synthesis of Testosterone; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of LHB] CTD PMID:16054318 PMID:23085516 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO Melatonin results in decreased expression of LPL mRNA CTD PMID:20738756 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 multiple interactions ISO Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of LRP1 protein] CTD PMID:33130240 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835
JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 protein] CTD PMID:35643323 NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 protein] CTD PMID:35643323 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein] CTD PMID:37348669 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA] CTD PMID:35568058 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Melatonin inhibits the reaction [Atrazine results in increased expression of MAP1LC3B protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]; Melatonin inhibits the reaction [Radon results in increased expression of MAP1LC3B protein]; Melatonin promotes the reaction [Paraquat results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Melatonin results in increased expression of and results in increased lipidation of MAP1LC3B protein; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]] CTD PMID:25259610 PMID:33107683 PMID:36421005 PMID:37028639 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK1 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk10 mitogen-activated protein kinase 10 increases expression ISO Melatonin results in increased expression of MAPK10 protein CTD PMID:19012662 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK3 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Melatonin results in increased expression of MAPK8 protein CTD PMID:19012662 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Melatonin results in increased expression of MAPK9 protein CTD PMID:19012662 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]; Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]]
Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]
CTD PMID:10617124 PMID:15842767 PMID:23963992 PMID:31833155 PMID:35526705 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mbp myelin basic protein multiple interactions EXP Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions ISO Melatonin inhibits the reaction [oxaliplatin results in decreased expression of MCL1 protein] CTD PMID:20626587 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic multiple interactions ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
JBrowse link
G Mff mitochondrial fission factor multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MFF mRNA] CTD PMID:33962019 NCBI chr 1:82,702,599...82,730,111
Ensembl chr 1:82,702,611...82,730,115
JBrowse link
G Mfn1 mitofusin 1 multiple interactions
increases expression
ISO [Doxorubicin results in increased susceptibility to Melatonin] which results in increased expression of MFN1 protein; [Melatonin results in increased susceptibility to Doxorubicin] which results in increased expression of MFN1 protein
Melatonin results in increased expression of MFN1 mRNA
CTD PMID:29966675 PMID:33962019 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388
JBrowse link
G Mfn2 mitofusin 2 multiple interactions
increases expression
ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein]
Melatonin affects the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of MFN2 mRNA]
Melatonin results in increased expression of MFN2 mRNA
CTD PMID:26882442 PMID:29966675 PMID:33962019 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G Mief2 mitochondrial elongation factor 2 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MIEF2 mRNA] CTD PMID:33962019 NCBI chr11:60,619,224...60,623,777
Ensembl chr11:60,619,224...60,623,777
JBrowse link
G Mir200a microRNA 200a decreases expression ISO melatonin decreases expression of Mir200a RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 4:156,139,353...156,139,442
Ensembl chr 4:156,139,353...156,139,442
JBrowse link
G Mir21a microRNA 21a multiple interactions ISO Melatonin inhibits the reaction [Cisplatin results in increased expression of MIR21 mRNA] CTD PMID:36006825 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
JBrowse link
G Mir497 microRNA 497 increases expression
multiple interactions
EXP Melatonin results in increased expression of MIR497 mRNA
MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
CTD PMID:28095641 NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626
JBrowse link
G Mir675 microRNA 675 increases expression ISO melatonin increases expression of Mir675 RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 7:142,130,801...142,130,884
Ensembl chr 7:142,130,801...142,130,884
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MKI67 protein]
Melatonin results in decreased expression of MKI67 mRNA; Melatonin results in decreased expression of MKI67 protein
CTD PMID:19028472 PMID:21062352 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mlkl mixed lineage kinase domain-like multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] CTD PMID:35844137 NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809
JBrowse link
G Mme membrane metallo endopeptidase multiple interactions ISO Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of MME protein] CTD PMID:33130240 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein]
Melatonin results in decreased expression of MMP2 mRNA; Melatonin results in decreased expression of MMP2 protein
[Doxorubicin co-treated with Melatonin] results in decreased expression of MMP2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP2 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in increased expression of MMP2 protein]
CTD PMID:16150113 PMID:16934674 PMID:29763682 PMID:33507000 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Galactose results in decreased expression of MMP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of and results in increased secretion of MMP9 protein]
Melatonin results in decreased expression of MMP9 mRNA; Melatonin results in decreased expression of MMP9 protein
Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 mRNA]; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 protein]
CTD PMID:16150113 PMID:33507000 PMID:34673010 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; Melatonin inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] CTD PMID:26519479 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial multiple interactions ISO Melatonin inhibits the reaction [Paraquat results in increased expression of COX2 protein] CTD PMID:37028639 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA] CTD PMID:25601058 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
increases expression
multiple interactions
ISO Melatonin analog binds to MTNR1A protein; Melatonin binds to MTNR1A protein
Melatonin results in increased expression of MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]
[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein; luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]
CTD PMID:11063602 PMID:17645693 PMID:20399199 PMID:23591044 PMID:28027439 More... NCBI chr 8:45,522,144...45,542,270
Ensembl chr 8:45,522,174...45,541,543
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions
increases expression
affects binding
EXP
ISO
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
Melatonin analog binds to MTNR1B protein; Melatonin binds to MTNR1B protein
CTD PMID:11063602 PMID:11270484 PMID:16030176 PMID:17645693 PMID:20399199 More... NCBI chr 9:15,773,910...15,785,852
Ensembl chr 9:15,735,824...15,785,852
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
increases activity
ISO
EXP
Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Melatonin inhibits the reaction [Methotrexate results in increased phosphorylation of MTOR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]
Melatonin results in increased activity of MTOR protein
CTD PMID:19054297 PMID:24799992 PMID:35568058 PMID:36421005 PMID:36890697 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 PMID:36566971 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression ISO melatonin increases expression of NCAM1 protein isoform 180 in hippocampus of ethanol treated rats RGD PMID:16207289 RGD:401959613 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA1 protein] CTD PMID:29330934 NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein] CTD PMID:29330934 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,556...165,915,162
JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 multiple interactions
decreases expression
affects response to substance
EXP Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]
Melatonin results in decreased expression of NEDD4 protein
[NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to Melatonin
CTD PMID:31325559 NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134
JBrowse link
G Nefh neurofilament, heavy polypeptide decreases phosphorylation EXP Melatonin analog results in decreased phosphorylation of NEFH protein; Melatonin results in decreased phosphorylation of NEFH protein CTD PMID:18231852 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
JBrowse link
G Nes nestin decreases expression
multiple interactions
ISO Melatonin results in decreased expression of NES protein
Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]
CTD PMID:16369854 PMID:17572393 PMID:21269327 NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
ISO
EXP
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Melatonin results in increased expression of NFE2L2 mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NFE2L2 mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]
Melatonin results in increased expression of NFE2L2 protein
CTD PMID:20433640 PMID:25288107 PMID:25550330 PMID:27871981 PMID:30372842 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NFKB1 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NFKB1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]
CTD PMID:19028472 PMID:21158907 PMID:23963992 PMID:30372842 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]; Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of and results in increased localization of NFKBIA protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]
CTD PMID:26283214 PMID:35526705 PMID:36566971 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions
EXP Melatonin results in decreased expression of NLRP3 mRNA
[Nickel co-treated with Melatonin] results in decreased expression of NLRP3 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Nickel inhibits the reaction [Melatonin results in decreased expression of NLRP3 mRNA]
CTD PMID:36504304 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
decreases expression
ISO Melatonin affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]
Melatonin results in decreased expression of NOS1 mRNA
CTD PMID:16948784 PMID:21442002 PMID:21986892 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
decreases expression
EXP
ISO
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA]
Melatonin results in increased expression of NOS2 mRNA
Melatonin results in decreased expression of NOS2 mRNA
Melatonin affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA]; Melatonin affects the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Amphetamine results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]
CTD PMID:12074098 PMID:16801527 PMID:16948784 PMID:18524487 PMID:21442002 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]] CTD PMID:21585521 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Notch2 notch 2 multiple interactions EXP Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form] CTD PMID:37277016 NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Melatonin inhibits the reaction [Galactose results in increased expression of NOX4 protein] CTD PMID:34673010 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions EXP Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206
JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:17198541 PMID:35093381 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO
EXP
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]
Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NQO1 mRNA]]
Melatonin results in increased expression of NQO1 protein
CTD PMID:20033131 PMID:20433640 PMID:24969583 PMID:25288107 PMID:27871981 More... NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
affects activity
ISO Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]
Melatonin affects the activity of NQO2 protein
CTD PMID:20399199 PMID:22289031 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein] CTD PMID:21689150 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA] CTD PMID:15617534 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization
ISO
EXP
Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Melatonin promotes the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]]
Melatonin inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Melatonin affects the localization of NR3C1 protein
CTD PMID:10463946 PMID:15813899 PMID:18395440 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NRF1 protein] CTD PMID:26882442 NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] CTD PMID:23963992 PMID:29476728 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Ocln occludin multiple interactions EXP Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN protein] CTD PMID:37598416 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of OPA1 mRNA]
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]
CTD PMID:33962019 PMID:35093381 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:99,631,964...99,638,533
Ensembl chr  X:99,633,760...99,638,475
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of PARP1 protein]
CTD PMID:25259610 PMID:29966675 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator decreases expression ISO Melatonin results in decreased expression of PAWR protein CTD PMID:15964511 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein]
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of PCNA protein]
Melatonin results in decreased expression of PCNA mRNA
CTD PMID:19028472 PMID:21062352 PMID:35643323 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO melatonin increases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291
JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479
JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PECR mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 1:72,298,331...72,323,480
Ensembl chr 1:72,298,326...72,323,473
JBrowse link
G Per1 period circadian clock 1 multiple interactions ISO Melatonin affects the reaction [Cadmium Chloride affects the expression of PER1]; Melatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA] CTD PMID:17590544 PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786
JBrowse link
G Per2 period circadian clock 2 multiple interactions
affects expression
ISO Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]
Melatonin affects the expression of PER2 mRNA
CTD PMID:17590544 PMID:21442002 PMID:25430725 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
JBrowse link
G Pf4 platelet factor 4 multiple interactions EXP [Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA CTD PMID:21461237 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]
Melatonin results in decreased expression of PGR protein alternative form
[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form; [Ethanol co-treated with Melatonin] results in increased expression of PGR protein alternative form; Ethanol inhibits the reaction [Melatonin results in decreased expression of PGR protein alternative form]; Melatonin inhibits the reaction [Ethanol results in decreased expression of PGR protein alternative form]
CTD PMID:22041583 PMID:23591044 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA] CTD PMID:35568058 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions
increases expression
ISO
EXP
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein]
Melatonin results in increased expression of PINK1 protein
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]
[PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PINK1 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]
CTD PMID:26882442 PMID:29966675 PMID:33962019 PMID:37028639 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PMAIP1 mRNA] CTD PMID:33962019 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions
decreases response to substance
ISO [Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein
Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]; Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]
Melatonin results in decreased susceptibility to POMC protein
CTD PMID:11478929 PMID:19301769 PMID:21332028 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of POU5F1 mRNA; Melatonin results in decreased expression of POU5F1 protein
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]
CTD PMID:27551335 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA protein]
Melatonin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of PPARA protein]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]
CTD PMID:35367536 PMID:36006825 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
multiple interactions
increases expression
ISO Melatonin results in decreased expression of PPARG mRNA
GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PPARG protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PPARG protein]
Melatonin results in increased expression of PPARG mRNA; Melatonin results in increased expression of PPARG protein
CTD PMID:20738756 PMID:29734669 PMID:33962019 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
ISO
EXP
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]
Melatonin results in increased expression of PPARGC1A mRNA
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]
CTD PMID:25159133 PMID:26882442 PMID:29966675 PMID:33962019 PMID:35367536 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
JBrowse link
G Prl prolactin multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL] CTD PMID:23085516 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 multiple interactions ISO Melatonin inhibits the reaction [Methotrexate results in decreased expression of PRMT1 protein] CTD PMID:36890697 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
JBrowse link
G Prnp prion protein multiple interactions
increases expression
ISO GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PRNP protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PRNP protein]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] CTD PMID:29734669 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of PROM1 mRNA; Melatonin results in decreased expression of PROM1 protein
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; N-caproylsphingosine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; N-caproylsphingosine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]
CTD PMID:30421542 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA] CTD PMID:23963992 NCBI chr 7:27,741,127...27,749,517
Ensembl chr 7:27,741,132...27,749,526
JBrowse link
G Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 multiple interactions EXP [Oxygen deficiency co-treated with Melatonin] results in decreased expression of PSMD3 protein CTD PMID:31325559 NCBI chr11:98,573,380...98,586,804
Ensembl chr11:98,573,380...98,586,805
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]
Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [Radon results in decreased expression of PTGS2 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]
CTD PMID:18588940 PMID:23376440 PMID:33107683 PMID:36421005 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pycard PYD and CARD domain containing decreases expression
multiple interactions
EXP Melatonin results in decreased expression of PYCARD mRNA; Melatonin results in decreased expression of PYCARD protein
Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin inhibits the reaction [Nickel results in increased expression of PYCARD mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of PYCARD protein]
CTD PMID:36504304 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rab7 RAB7, member RAS oncogene family multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of RAB7A protein] CTD PMID:26882442 NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein] CTD PMID:10965999 PMID:15813899 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RELA protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA protein]; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [[Formaldehyde co-treated with diisononyl phthalate] promotes the reaction [OVAL protein results in increased phosphorylation of RELA protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]; Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]; Melatonin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]
CTD PMID:20433640 PMID:22225513 PMID:22526374 PMID:26283214 PMID:27871981 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Renbp renin binding protein multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of RENBP protein] CTD PMID:29763682 NCBI chr  X:72,965,727...72,974,408
Ensembl chr  X:72,965,727...72,974,456
JBrowse link
G Rgn regucalcin multiple interactions ISO Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] CTD PMID:29734669 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK1 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 PMID:35844137 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK3 protein]
[Melatonin co-treated with Thioacetamide] results in increased expression of RIPK3 protein
CTD PMID:29763682 PMID:31967703 PMID:35844137 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
G Rora RAR-related orphan receptor alpha affects binding EXP Melatonin binds to RORA protein CTD PMID:16030176 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528
JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318
JBrowse link
G Rpl23 ribosomal protein L23 multiple interactions EXP Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263
JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions EXP Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of RPL3 protein] CTD PMID:31325559 NCBI chr15:79,961,993...79,967,553
Ensembl chr15:79,961,992...79,976,069
JBrowse link
G Rps19 ribosomal protein S19 multiple interactions EXP Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 7:24,584,013...24,589,236
Ensembl chr 7:24,583,796...24,589,231
JBrowse link
G Rps7 ribosomal protein S7 multiple interactions EXP Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr12:28,680,846...28,685,952
Ensembl chr12:28,680,853...28,685,952
JBrowse link
G Runx2 runt related transcription factor 2 increases expression
multiple interactions
ISO Melatonin results in increased expression of RUNX2 mRNA
Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of RUNX2 mRNA]
CTD PMID:20738756 PMID:31809235 PMID:38000455 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G S100g S100 calcium binding protein G increases expression
multiple interactions
ISO Melatonin results in increased expression of S100G mRNA; Melatonin results in increased expression of S100G protein
Hydrogen Peroxide promotes the reaction [Melatonin results in increased expression of S100G protein]
CTD PMID:20041988 NCBI chr  X:161,744,988...161,747,595
Ensembl chr  X:161,744,988...161,747,595
JBrowse link
G Selenom selenoprotein M multiple interactions
affects response to substance
EXP [SELENOM protein affects the susceptibility to Melatonin] which affects the abundance of Malondialdehyde; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Melatonin inhibits the reaction [SELENOM protein affects the susceptibility to Nickel]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]] CTD PMID:36504304 NCBI chr11:3,464,684...3,467,351
Ensembl chr11:3,464,684...3,467,351
JBrowse link
G Setdb1 SET domain, bifurcated 1 multiple interactions EXP Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of SETDB1 protein] CTD PMID:35643323 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of SIRT1 protein
Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of and results in decreased localization of SIRT1 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]
CTD PMID:21062352 PMID:25159133 PMID:29966675 PMID:36566971 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions EXP Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:20964710 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA]
Melatonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:21599003 PMID:23963992 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]
CTD PMID:17198541 PMID:29763682 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]
Melatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Snca synuclein, alpha multiple interactions ISO
EXP
Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]
CTD PMID:17645694 PMID:18289173 PMID:34808223 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases activity
increases expression
ISO
EXP
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]
Melatonin results in increased activity of SOD1 protein
Melatonin results in increased expression of SOD1 mRNA
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of SOD1 protein]
CTD PMID:11523592 PMID:15589378 PMID:17198541 PMID:19405147 PMID:19680607 More... NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases activity
increases expression
ISO
EXP
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD2 protein]
luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]
Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
CTD PMID:10942521 PMID:11523592 PMID:15589378 PMID:16098089 PMID:20210856 More... NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 protein] CTD PMID:38000455 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO
EXP
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein]
Melatonin results in increased expression of SQSTM1 protein
Melatonin inhibits the reaction [Atrazine results in increased expression of SQSTM1 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 protein]; Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]
CTD PMID:25259610 PMID:26882442 PMID:31330490 PMID:33107683 PMID:36421005 More... NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein] CTD PMID:21689150 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:21158907 PMID:22225513 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases response to substance
increases phosphorylation
EXP
ISO
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
STAT3 protein results in increased susceptibility to Melatonin
Melatonin results in increased phosphorylation of STAT3 protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STAT3 protein]
CTD PMID:19028472 PMID:21342247 PMID:22225513 PMID:23963992 PMID:27871981 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
G Syp synaptophysin multiple interactions ISO Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]; Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein] CTD PMID:17572393 PMID:19409439 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Syt5 synaptotagmin V multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 7:4,542,764...4,550,540
Ensembl chr 7:4,542,764...4,550,540
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin CTD PMID:16952380 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]
Melatonin results in increased expression of TFAM mRNA
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]
CTD PMID:21797922 PMID:26882442 PMID:33962019 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:27551335 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251
JBrowse link
G Tfrc transferrin receptor decreases expression ISO Melatonin results in decreased expression of TFRC mRNA; Melatonin results in decreased expression of TFRC protein CTD PMID:17091493 PMID:18571630 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
[Tretinoin co-treated with Melatonin] results in increased expression of TGFB1 mRNA
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]
CTD PMID:9649124 PMID:17572393 PMID:23963992 PMID:26882442 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO
EXP
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]
CTD PMID:18289173 PMID:19409439 PMID:20964710 PMID:24969583 PMID:34808223 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein] CTD PMID:37598416 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of TLR4 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TLR4 protein]
CTD PMID:27413111 PMID:28238930 PMID:34808223 PMID:36566971 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO Melatonin inhibits the reaction [Paraquat results in increased expression of TLR9 protein] CTD PMID:37028639 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
EXP
ISO
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of TNF protein]; Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]]
melatonin inhibits the reaction [liver reperfusion increases secretion of Tnf protein in plasma]
Melatonin results in decreased secretion of TNF protein
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]; Melatonin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Melatonin inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]
CTD
RGD
PMID:15714805 PMID:16373423 PMID:17602819 PMID:19028472 PMID:19080501 More... RGD:2325259 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases response to substance EXP TNFRSF1B protein results in increased susceptibility to Melatonin CTD PMID:21342247 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TRADD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TRADD protein] CTD PMID:29763682 PMID:35844137 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
JBrowse link
G Trappc6a trafficking protein particle complex 6A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA] CTD PMID:31330490 NCBI chr 7:19,242,595...19,250,070
Ensembl chr 7:19,242,320...19,250,070
JBrowse link
G Trf transferrin increases expression
multiple interactions
ISO Melatonin results in increased expression of TF protein
[Melatonin results in increased expression of TF protein] which affects the abundance of Iron
CTD PMID:18571630 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of TP53 protein
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of TP53 mRNA]; Melatonin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Glucose results in increased expression of TP53 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of TRP53 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]
Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
CTD PMID:12071473 PMID:14993511 PMID:19012662 PMID:20041988 PMID:20964710 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Melatonin inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased expression of TRPV1 protein] CTD PMID:34146326 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]; Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA] CTD PMID:16948784 PMID:23085516 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] CTD PMID:27871981 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 multiple interactions ISO TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein] CTD PMID:30421542 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
decreases expression
EXP Nickel inhibits the reaction [Melatonin results in decreased expression of TXN1 mRNA] CTD PMID:36504304 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein decreases expression
multiple interactions
EXP Melatonin results in decreased expression of TXNIP mRNA
Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of TXNIP mRNA]
CTD PMID:36504304 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
JBrowse link
G Txnrd3 thioredoxin reductase 3 multiple interactions
decreases response to substance
EXP TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin results in decreased susceptibility to nickel chloride]
TXNRD3 gene mutant form results in decreased susceptibility to Melatonin
CTD PMID:36421005 NCBI chr 6:89,620,970...89,652,511
Ensembl chr 6:89,620,970...89,652,511
JBrowse link
G Ubb ubiquitin B multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr11:62,442,329...62,444,037
Ensembl chr11:62,441,997...62,444,039
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions ISO Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]; Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA] CTD PMID:22846377 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 6:72,345,032...72,357,451
Ensembl chr 6:72,345,777...72,357,451
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of VEGFA mRNA]
CTD PMID:32554039 PMID:33962019 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vps45 vacuolar protein sorting 45 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 3:95,907,144...95,969,715
Ensembl chr 3:95,907,144...95,965,778
JBrowse link
G Wnt3 wingless-type MMTV integration site family, member 3 multiple interactions ISO Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]] CTD PMID:35526705 NCBI chr11:103,665,000...103,708,854
Ensembl chr11:103,664,976...103,708,783
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of WNT3A protein] CTD PMID:31809235 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein]
Melatonin inhibits the reaction [Atrazine affects the splicing of XBP1]
CTD PMID:17645694 PMID:25259610 PMID:28070110 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Yap1 yes-associated protein 1 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:35093381 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide multiple interactions ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein] CTD PMID:18078454 NCBI chr 2:163,837,082...163,860,508
Ensembl chr 2:163,836,880...163,860,508
JBrowse link
G Yy1 YY1 transcription factor multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA] CTD PMID:28095641 NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
JBrowse link
G Zp2 zona pellucida glycoprotein 2 multiple interactions EXP Melatonin inhibits the reaction [bisphenol A results in increased cleavage of ZP2 protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in increased cleavage of ZP2 protein] CTD PMID:28178360 PMID:31931096 NCBI chr 7:119,725,985...119,744,514
Ensembl chr 7:119,725,995...119,744,514
JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B affects binding
multiple interactions
EXP mesulergine binds to HTR2B protein
Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]
CTD PMID:11930908 NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects binding
multiple interactions
ISO mesulergine binds to HTR2C protein
Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]
N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:18083778 PMID:19439326 PMID:19700373 PMID:29458138 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 affects binding
multiple interactions
ISO mesulergine binds to HTR7 protein
[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
JBrowse link
G Prl prolactin multiple interactions ISO mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein] CTD PMID:1421203 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
methysergide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases activity ISO Methysergide results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects activity ISO Methysergide affects the activity of CALCA protein CTD PMID:10075105 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B affects binding ISO Methysergide binds to HTR1B protein CTD PMID:11888550 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
JBrowse link
midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Agt angiotensinogen multiple interactions ISO midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity
multiple interactions
ISO midostaurin results in decreased activity of AKR1C3 protein
midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
CTD PMID:33025066 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412
JBrowse link
G Flt3 FMS-like tyrosine kinase 3 decreases response to substance
decreases activity
ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein
CTD PMID:21980431 NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299
JBrowse link
G Gypa glycophorin A decreases expression ISO midostaurin results in decreased expression of GYPA protein CTD PMID:19573588 NCBI chr 8:81,220,674...81,237,414
Ensembl chr 8:81,220,410...81,237,171
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Itgb3 integrin beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mpl myeloproliferative leukemia virus oncogene increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 4:118,299,609...118,314,771
Ensembl chr 4:118,299,612...118,314,710
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
Mitragynine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects activity ISO mitragynine affects the activity of ABCG2 protein CTD PMID:30083819 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
decreases activity
multiple interactions
ISO CES1 protein results in increased hydrolysis of mitragynine
mitragynine results in decreased activity of CES1 protein
[mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir
CTD PMID:25445008 PMID:37716419 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
ISO mitragynine results in increased activity of CYP1A2 protein
mitragynine results in increased expression of CYP1A2 mRNA; mitragynine results in increased expression of CYP1A2 protein
CTD PMID:23274770 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO mitragynine results in decreased activity of CYP2C19 protein CTD PMID:31707106 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases expression
decreases activity
ISO mitragynine results in increased expression of CYP2D6 protein
mitragynine results in decreased activity of CYP2D6 protein
CTD PMID:23274770 PMID:31707106 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases expression
multiple interactions
ISO mitragynine results in decreased expression of KCNH2 protein
mitragynine binds to and results in decreased activity of KCNH2 protein
CTD PMID:27260674 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP mitragynine binds to OPRD1 protein CTD PMID:27192616 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
ISO
EXP
mitragynine binds to OPRK1 protein
mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
CTD PMID:27192616 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases activity
affects binding
ISO
EXP
mitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; mitragynine binds to and results in increased activity of OPRM1 protein; mitragynine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]
mitragynine results in increased activity of OPRM1 protein
mitragynine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
mitragynine binds to OPRM1 protein
CTD PMID:23608241 PMID:27192616 PMID:32734307 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP mitragynine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein] CTD PMID:21513785 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP mitragynine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; mitragynine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21513785 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
N,N-dimethyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Fmo3 flavin containing monooxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A decreases response to substance
multiple interactions
affects response to substance
ISO HTR2A gene SNP results in decreased susceptibility to N,N-Dimethyltryptamine
N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A protein
HTR2A protein affects the susceptibility to N,N-Dimethyltryptamine
CTD PMID:16314884 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
N-acetylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein] CTD PMID:19961921 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions
increases glucuronidation
ISO methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate inhibits the reaction [UGT1A6 protein results in increased glucuronidation of N-acetylserotonin] CTD PMID:34910929 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
paxilline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]] CTD PMID:12807996 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]] CTD PMID:12807996 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
ISO [Bexarotene co-treated with paxilline] results in increased expression of FASN mRNA; [CD 3254 co-treated with paxilline] results in increased expression of FASN mRNA
paxilline results in increased expression of FASN mRNA
CTD PMID:32123961 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 affects response to substance ISO KCNMA1 protein affects the susceptibility to paxilline CTD PMID:22226998 NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559
JBrowse link
G Mlxipl MLX interacting protein-like increases expression ISO paxilline results in increased expression of MLXIPL mRNA CTD PMID:32123961 NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression
ISO [Bexarotene co-treated with paxilline] results in increased expression of NR0B2 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of NR0B2 mRNA
paxilline results in increased expression of NR0B2 mRNA
CTD PMID:32123961 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
ISO [Bexarotene co-treated with paxilline] results in increased expression of NR1H3 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of NR1H3 mRNA; NR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]
paxilline results in increased expression of NR1H3 mRNA
CTD PMID:20079722 PMID:32123961 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression
multiple interactions
ISO paxilline results in increased expression of NRIP1 mRNA
[CD 3254 co-treated with paxilline] results in increased expression of NRIP1 mRNA
CTD PMID:32123961 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]] CTD PMID:12807996 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions
increases expression
ISO [CD 3254 co-treated with paxilline] results in increased expression of SCD mRNA
paxilline results in increased expression of SCD mRNA
CTD PMID:32123961 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
ISO [Bexarotene co-treated with paxilline] results in increased expression of SREBF1 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of SREBF1 mRNA
paxilline results in increased expression of SREBF1 mRNA
CTD PMID:32123961 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]] CTD PMID:12807996 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
physostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 3:59,939,209...59,947,578
Ensembl chr 3:59,933,138...59,947,581
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
affects expression
increases expression
ISO
EXP
[Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]] which results in decreased carbamoylation of ACHE protein; ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine affects the expression of ACHE mRNA
[Corticosterone co-treated with Physostigmine] results in decreased activity of ACHE protein; Physostigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
asoxime chloride affects the reaction [Physostigmine results in decreased activity of ACHE protein]; asoxime chloride promotes the reaction [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Physostigmine affects the expression of and affects the activity of ACHE protein; Physostigmine affects the reaction [Sarin affects the expression of ACHE mRNA]; Physostigmine affects the reaction [Sarin affects the expression of and affects the activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine results in increased expression of ACHE protein
CTD PMID:4859365 PMID:11740913 PMID:14644616 PMID:15586889 PMID:19283689 More... NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G App amyloid beta precursor protein increases secretion ISO Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915 PMID:8624119 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO Physostigmine inhibits the reaction [Sarin results in decreased activity of BCHE protein]
Physostigmine results in decreased activity of BCHE protein
CTD PMID:19283689 PMID:32795450 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Physostigmine inhibits the reaction [Corticosterone results in decreased expression of CCL2 mRNA] CTD PMID:28500787 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Physostigmine results in decreased activity of CES2 protein CTD PMID:9169443 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
JBrowse link
G Chat choline acetyltransferase decreases expression
increases expression
ISO Physostigmine results in decreased expression of CHAT protein
Physostigmine results in increased expression of CHAT protein
CTD PMID:22640809 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions ISO Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of FOS mRNA] CTD PMID:11337201 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein] CTD PMID:28499986 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Physostigmine affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions ISO [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Physostigmine affects the reaction [Corticosterone affects the expression of IL1B mRNA] CTD PMID:28500787 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Corticosterone co-treated with Physostigmine] results in decreased expression of IL6 mRNA CTD PMID:28500787 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of JUN mRNA] CTD PMID:11337201 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Lif leukemia inhibitory factor multiple interactions EXP [Corticosterone co-treated with Physostigmine] results in decreased expression of LIF mRNA CTD PMID:28500787 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Physostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein] CTD PMID:28499986 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Osm oncostatin M multiple interactions EXP [Corticosterone co-treated with Physostigmine] results in increased expression of OSM mRNA CTD PMID:28500787 PMID:29846716 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 increases expression ISO Physostigmine results in increased expression of SLC18A3 protein CTD PMID:22640809 NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:28499986 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation EXP Physostigmine results in decreased phosphorylation of STAT3 protein CTD PMID:28500787 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Syp synaptophysin multiple interactions EXP Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:28499986 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Corticosterone co-treated with Physostigmine] results in increased expression of TNF mRNA CTD PMID:28500787 PMID:29846716 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
rescinnamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO rescinnamine results in increased expression of ABCB1 mRNA CTD PMID:7476894 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO rescinnamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
reserpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity
ISO Reserpine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Reserpine results in decreased activity of ABCB11 protein
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
decreases activity
increases expression
ISO
EXP
Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
Reserpine results in decreased activity of ABCB1 protein
Reserpine results in increased expression of ABCB1 mRNA; Reserpine results in increased expression of ABCB1 protein
CTD PMID:7476894 PMID:8632764 PMID:10617675 PMID:12235267 PMID:19528478 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of irinotecan] CTD PMID:12869632 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Ache acetylcholinesterase multiple interactions
affects activity
ISO [Plant Extracts results in increased abundance of Dronabinol] inhibits the reaction [Reserpine affects the activity of ACHE protein] CTD PMID:28212939 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Adra1d adrenergic receptor, alpha 1d increases response to substance
increases expression
ISO ADRA1D protein results in increased susceptibility to Reserpine
Reserpine results in increased expression of ADRA1D mRNA
CTD PMID:15159276 PMID:17676312 NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203
JBrowse link
G Adra2a adrenergic receptor, alpha 2a increases expression ISO Reserpine results in increased expression of ADRA2A mRNA CTD PMID:11264240 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
JBrowse link
G Adrb1 adrenergic receptor, beta 1 increases expression
increases stability
ISO Reserpine results in increased expression of ADRB1 mRNA; Reserpine results in increased expression of ADRB1 protein
Reserpine results in increased stability of ADRB1 mRNA
CTD PMID:1336118 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545
JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression ISO Reserpine results in increased expression of ADRB2 mRNA CTD PMID:1664493 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression ISO Reserpine results in increased expression of AGTR2 mRNA; Reserpine results in increased expression of AGTR2 protein CTD PMID:20964730 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO Reserpine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions
EXP Reserpine results in decreased phosphorylation of AKT1 protein
arsenic trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein]
CTD PMID:26114099 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Amd1 S-adenosylmethionine decarboxylase 1 multiple interactions EXP Reserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein] CTD PMID:17371283 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184
JBrowse link
G Ar androgen receptor multiple interactions ISO Reserpine inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Arc activity regulated cytoskeletal-associated protein multiple interactions ISO Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA] CTD PMID:7722525 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein] CTD PMID:19463876 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein] CTD PMID:19463876 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression
multiple interactions
EXP
ISO
Reserpine results in decreased expression of BDNF protein
cerebrolysin inhibits the reaction [Reserpine results in decreased expression of BDNF protein]; Fluoxetine inhibits the reaction [Reserpine results in decreased expression of BDNF protein]
arsenic trioxide promotes the reaction [Reserpine results in decreased expression of BDNF protein]
CTD PMID:26114099 PMID:33279466 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Reserpine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G C3 complement component 3 affects expression ISO Reserpine affects the expression of C3 mRNA CTD PMID:18363858 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein] CTD PMID:19463876 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein] CTD PMID:19463876 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression
ISO Plant Extracts inhibits the reaction [Reserpine results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Reserpine results in decreased expression of CAT protein]
Reserpine results in increased expression of CAT protein
CTD PMID:14685008 PMID:16444668 PMID:19109989 PMID:19761039 PMID:20628966 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Reserpine results in decreased expression of CCND1 mRNA; Reserpine results in decreased expression of CCND1 protein CTD PMID:19607803 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Chga chromogranin A multiple interactions
increases expression
increases activity
EXP
ISO
CHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]
Reserpine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:8189248 PMID:12799369 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287
JBrowse link
G Chgb chromogranin B increases expression ISO Reserpine results in increased expression of CHGB mRNA; Reserpine results in increased expression of CHGB protein CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 2:132,623,562...132,636,999
Ensembl chr 2:132,623,198...132,636,999
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS increases expression
decreases expression
ISO Reserpine results in increased expression of CHRM1 mRNA
Reserpine results in decreased expression of CHRM1 protein
CTD PMID:1506860 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression ISO Reserpine results in decreased expression of CNR1 mRNA CTD PMID:11358453 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Reserpine results in increased expression of CPE mRNA CTD PMID:8189248 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088
JBrowse link
G Crem cAMP responsive element modulator multiple interactions
increases expression
ISO Reserpine promotes the reaction [CREM protein binds to TH promoter]
Reserpine results in increased expression of CREM mRNA alternative form; Reserpine results in increased expression of CREM protein; Reserpine results in increased expression of CREM protein alternative form
CTD PMID:8810303 PMID:11438978 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Reserpine results in increased expression of CRH mRNA; Reserpine results in increased expression of CRH protein CTD PMID:1850078 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480 PMID:18493746 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression ISO Reserpine results in increased expression of CYP3A5 protein CTD PMID:8632764 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Dbh dopamine beta hydroxylase decreases activity
increases expression
increases stability
increases activity
ISO Reserpine results in decreased activity of DBH protein
Reserpine results in increased expression of DBH mRNA
Reserpine results in increased stability of DBH protein
Reserpine results in increased activity of DBH protein
CTD PMID:1359376 PMID:2325165 PMID:7984052 PMID:8189248 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
JBrowse link
G Ddc dopa decarboxylase increases expression ISO Reserpine results in increased expression of DDC mRNA CTD PMID:1359376 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Reserpine results in increased expression of DRD1 mRNA CTD PMID:8419537 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases expression
EXP
ISO
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
Reserpine results in increased expression of DRD2 mRNA; Reserpine results in increased expression of DRD2 mRNA alternative form
CTD PMID:1331675 PMID:8419537 PMID:11172060 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO [Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA; eticlopride inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA]; Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]]
Reserpine results in increased expression of EGR1 mRNA; Reserpine results in increased expression of EGR1 protein
CTD PMID:1347779 PMID:8063705 PMID:9729266 PMID:9890435 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance ISO ERBB2 protein results in increased susceptibility to Reserpine CTD PMID:8093862 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542
JBrowse link
G Fabp7 fatty acid binding protein 7, brain affects expression ISO Reserpine affects the expression of FABP7 mRNA CTD PMID:18363858 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
increases phosphorylation
ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; 3,7-dimethyl-1-propargylxanthine inhibits the reaction [Reserpine results in increased expression of FOS protein]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]; Reserpine promotes the reaction [Amphetamine results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
Reserpine results in increased expression of FOS mRNA; Reserpine results in increased expression of FOS protein
Reserpine results in increased phosphorylation of FOS protein
CTD PMID:1359376 PMID:1686849 PMID:2118661 PMID:7845612 PMID:7914358 More... NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
ISO Reserpine results in increased expression of GAD1 mRNA
Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]
CTD PMID:8774452 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
increases expression
multiple interactions
ISO Reserpine results in decreased expression of GAL mRNA
Reserpine results in increased expression of GAL mRNA
Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA]
CTD PMID:1279347 PMID:1698642 PMID:1705056 PMID:1717808 PMID:9512271 More... NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
JBrowse link
G Gast gastrin multiple interactions ISO Reserpine inhibits the reaction [Levodopa results in decreased cleavage of GAST protein] CTD PMID:10332097 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Reserpine results in increased expression of GCH1 mRNA; Reserpine results in increased expression of GCH1 mRNA alternative form CTD PMID:8103077 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Reserpine results in increased expression of GCNT3 mRNA CTD PMID:26198647 NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression ISO Reserpine results in increased expression of GNAI1 protein CTD PMID:11264240 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression ISO Reserpine results in increased expression of GNAI2 mRNA; Reserpine results in increased expression of GNAI2 protein CTD PMID:8419537 PMID:11264240 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression ISO Reserpine results in increased expression of GNAI3 protein CTD PMID:11264240 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O increases expression ISO Reserpine results in increased expression of GNAO1 mRNA; Reserpine results in increased expression of GNAO1 protein CTD PMID:8419537 PMID:11264240 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016
JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression
ISO Reserpine results in increased expression of GNAS mRNA; Reserpine results in increased expression of GNAS protein
Reserpine results in decreased expression of GNAS protein alternative form
CTD PMID:1336118 PMID:8419537 PMID:11264240 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537
JBrowse link
G Grm5 glutamate receptor, metabotropic 5 decreases expression
increases expression
ISO Reserpine results in decreased expression of GRM5 mRNA
Reserpine results in increased expression of GRM5 protein
CTD PMID:16890937 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Reserpine results in increased expression of HGF protein CTD PMID:16081063 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) multiple interactions EXP HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine] CTD PMID:20072119 NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A decreases expression EXP Reserpine results in decreased expression of HTR1A protein CTD PMID:26114099 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions ISO IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 6:142,244,151...142,249,546
Ensembl chr 6:142,244,149...142,249,687
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
ISO Reserpine results in decreased expression of IL10 mRNA; Reserpine results in decreased expression of IL10 protein
SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein]
CTD PMID:16985181 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il18 interleukin 18 increases expression ISO Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Jun jun proto-oncogene increases expression ISO Reserpine results in increased expression of JUN mRNA CTD PMID:1359376 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Junb jun B proto-oncogene multiple interactions ISO Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]] CTD PMID:1347779 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
JBrowse link
G Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 decreases activity
multiple interactions
ISO Reserpine results in decreased activity of KCNA3 protein
[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 3:106,943,486...106,947,223
Ensembl chr 3:106,943,485...106,945,386
JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 increases expression ISO Reserpine results in increased expression of KCNA5 mRNA CTD PMID:12606256 NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375
JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 decreases expression ISO Reserpine results in decreased expression of KCND2 mRNA CTD PMID:12606256 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804
JBrowse link
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 decreases expression ISO Reserpine results in decreased expression of KCND3 mRNA CTD PMID:12606256 NCBI chr 3:105,359,206...105,581,318
Ensembl chr 3:105,359,646...105,581,318
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions
ISO Reserpine results in decreased activity of KCNH2 protein
[Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD PMID:21362439 PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Lep leptin increases expression EXP Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Myc myelocytomatosis oncogene increases response to substance
decreases expression
EXP
ISO
MYC protein results in increased susceptibility to Reserpine
Reserpine results in decreased expression of MYC protein
CTD PMID:8093862 PMID:19607803 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Reserpine results in increased expression of NCF1 mRNA; Reserpine results in increased expression of NCF1 protein CTD PMID:20964730 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases activity EXP Reserpine results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Ngf nerve growth factor increases expression ISO Reserpine results in increased expression of NGF mRNA; Reserpine results in increased expression of NGF protein CTD PMID:1996081 PMID:8593794 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO Reserpine results in increased expression of NOS1 mRNA; Reserpine results in increased expression of NOS1 protein CTD PMID:7533141 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Npy neuropeptide Y multiple interactions
increases expression
decreases expression
ISO Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]
Reserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY protein
Reserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY protein
CTD PMID:1671012 PMID:1676830 PMID:1687976 PMID:1698642 PMID:1713314 More... NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
ISO
EXP
[Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
Reserpine results in decreased activity of NR1I3 protein
CTD PMID:17041008 PMID:30203046 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Reserpine results in increased expression of NR3C1 mRNA CTD PMID:7984052 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions
decreases expression
EXP arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Nts neurotensin increases expression ISO Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression
multiple interactions
ISO
EXP
Reserpine results in decreased expression of ODC1 protein
Reserpine inhibits the reaction [CB 3717 results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [CB 3717 results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]
CTD PMID:6519379 PMID:9194572 PMID:10354516 PMID:17371283 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase increases expression ISO Reserpine results in increased expression of PAM mRNA CTD PMID:8189248 NCBI chr 1:97,748,816...98,023,578
Ensembl chr 1:97,722,839...98,023,371
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Reserpine results in increased expression of PCSK2 mRNA CTD PMID:8189248 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205
JBrowse link
G Penk preproenkephalin multiple interactions
increases expression
decreases expression
ISO Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]
Reserpine results in increased expression of PENK mRNA; Reserpine results in increased expression of PENK protein
Reserpine results in decreased expression of PENK mRNA
CTD PMID:1331675 PMID:1850078 PMID:3188958 PMID:3838946 PMID:4078631 More... NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions
increases expression
decreases expression
ISO Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT protein
Reserpine results in increased expression of PNMT mRNA
CTD PMID:1359376 PMID:1687976 PMID:1714554 PMID:2903502 PMID:8063705 More... NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression
multiple interactions
ISO Reserpine results in increased expression of POMC mRNA; Reserpine results in increased expression of POMC protein alternative form
POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]
CTD PMID:8479280 PMID:20504635 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha decreases expression EXP Reserpine results in decreased expression of PRKACA protein CTD PMID:26114099 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
JBrowse link
G Prl prolactin increases expression ISO Reserpine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Reserpine results in increased expression of PTGS2 protein CTD PMID:16081063 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase increases expression ISO Reserpine results in increased expression of PTS mRNA CTD PMID:7545485 NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024
JBrowse link
G Rasd2 RASD family, member 2 decreases expression ISO Reserpine results in decreased expression of RASD2 mRNA CTD PMID:16352400 NCBI chr 8:75,940,572...75,950,741
Ensembl chr 8:75,940,572...75,950,741
JBrowse link
G Rgs10 regulator of G-protein signalling 10 decreases expression ISO Reserpine results in decreased expression of RGS10 mRNA CTD PMID:14505795 NCBI chr 7:127,975,345...128,020,993
Ensembl chr 7:127,975,345...128,020,482
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Reserpine results in decreased expression of RGS2 mRNA CTD PMID:14505795 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Reserpine results in decreased expression of RGS4 mRNA CTD PMID:14505795 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211
JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression ISO Reserpine results in decreased expression of RGS5 mRNA CTD PMID:14505795 NCBI chr 1:169,483,070...169,523,367
Ensembl chr 1:169,483,070...169,523,382
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression ISO Reserpine results in decreased expression of RGS8 mRNA CTD PMID:14505795 NCBI chr 1:153,528,612...153,573,415
Ensembl chr 1:153,528,771...153,576,069
JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance
decreases expression
EXP
ISO
RGS9 affects the susceptibility to Reserpine
Reserpine results in decreased expression of RGS9 mRNA
CTD PMID:14505795 PMID:15728856 NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955
JBrowse link
G Scg2 secretogranin II increases expression ISO Reserpine results in increased expression of SCG2 mRNA CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 1:79,412,083...79,417,743
Ensembl chr 1:79,412,386...79,417,837
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Siah1a siah E3 ubiquitin protein ligase 1A increases expression ISO Reserpine results in increased expression of SIAH1 mRNA CTD PMID:19607803 NCBI chr 8:87,442,450...87,472,634
Ensembl chr 8:87,450,635...87,472,562
JBrowse link
G Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 decreases activity
multiple interactions
EXP
ISO
Reserpine results in decreased activity of SLC18A1 protein
Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]
CTD PMID:8245983 PMID:21712771 NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects binding
decreases activity
multiple interactions
increases expression
affects response to substance
decreases response to substance
ISO
EXP
Reserpine binds to SLC18A2 protein
Reserpine results in decreased activity of SLC18A2 protein
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]
SLC18A2 protein binds to Reserpine
Reserpine results in increased expression of SLC18A2 mRNA
SLC18A2 affects the susceptibility to Reserpine
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]
SLC18A2 gene SNP results in decreased susceptibility to Reserpine
CTD PMID:1438304 PMID:7912402 PMID:8189248 PMID:9038139 PMID:15475732 More... NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 decreases expression ISO Reserpine results in decreased expression of SLC6A2 mRNA CTD PMID:7478180 PMID:7616203 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 decreases activity
affects response to substance
EXP Reserpine results in decreased activity of SLC6A3 protein
SLC6A3 gene mutant form affects the susceptibility to Reserpine
CTD PMID:17664021 PMID:19615345 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 decreases expression ISO Reserpine results in decreased expression of SLC6A4 mRNA CTD PMID:10027743 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Snca synuclein, alpha affects response to substance EXP SNCA protein mutant form affects the susceptibility to Reserpine CTD PMID:18622040 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Reserpine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Syt7 synaptotagmin VII multiple interactions ISO [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544
JBrowse link
G Tac1 tachykinin 1 multiple interactions
increases expression
ISO [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA; Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:9751140 PMID:17719177 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Reserpine results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251
JBrowse link
G Th tyrosine hydroxylase increases expression
increases activity
decreases expression
affects activity
increases stability
multiple interactions
EXP
ISO
Reserpine results in increased expression of TH mRNA
Reserpine results in increased activity of TH protein
Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein
Reserpine results in decreased expression of TH mRNA
Reserpine affects the activity of TH protein
Reserpine results in increased stability of TH mRNA
Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein
CTD PMID:1350653 PMID:1359376 PMID:1676830 PMID:1687822 PMID:1687976 More... NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Reserpine results in increased expression of TNF protein
cerebrolysin inhibits the reaction [Reserpine results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [Reserpine results in increased expression of TNF protein]
CTD PMID:33279466 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases expression
ISO IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases activity
decreases activity
ISO Reserpine results in increased activity of TPH1 protein
Reserpine results in decreased activity of TPH1 protein
CTD PMID:8369965 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
JBrowse link
G Try10 trypsin 10 decreases expression
increases expression
ISO Reserpine results in decreased expression of PRSS1 protein
Reserpine results in increased expression of PRSS1 protein
CTD PMID:8625754 NCBI chr 6:41,331,039...41,334,878
Ensembl chr 6:41,331,039...41,334,848
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Reserpine results in increased expression of VGF mRNA CTD PMID:8189248 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205
JBrowse link
G Vip vasoactive intestinal polypeptide increases expression ISO Reserpine results in increased expression of VIP mRNA CTD PMID:1850078 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-Coenzyme A acetyltransferase 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; AG 1879 inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; Serotonin results in increased expression of and results in increased activity of ACAT1 protein
Serotonin results in increased expression of ACAT1 mRNA alternative form
CTD PMID:16157345 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:26408985 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases activity
multiple interactions
EXP Serotonin results in increased activity of AKT1 protein
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]
CTD PMID:22975078 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases response to substance
ISO Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] which results in increased susceptibility to Serotonin]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin] CTD PMID:28915354 PMID:34902447 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Aqp3 aquaporin 3 multiple interactions
increases expression
ISO [Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
CTD PMID:25766885 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO
EXP
[Butyrates co-treated with Serotonin] results in increased expression of BDNF mRNA; [trichostatin A co-treated with Serotonin] results in increased expression of BDNF mRNA; [Valproic Acid co-treated with Serotonin] results in increased expression of BDNF mRNA
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD PMID:19360904 PMID:26408985 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
increases secretion
ISO [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12791437 PMID:14991081 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] CTD PMID:24650663 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein] CTD PMID:24650663 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin] CTD PMID:11435997 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
increases activity
ISO Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein]
Serotonin results in increased activity of CFTR protein
CTD PMID:15151902 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline acetyltransferase multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:26408985 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of CNR1 protein] CTD PMID:30611738 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:26408985 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
ISO 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]; corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin] CTD PMID:14575894 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 affects expression
affects secretion
ISO Serotonin affects the expression of CXCL8 mRNA
Serotonin affects the secretion of CXCL8 protein
CTD PMID:15802305 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Dbh dopamine beta hydroxylase multiple interactions EXP DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]; DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] CTD PMID:15148402 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] CTD PMID:20887679 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein] CTD PMID:20887679 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G En2 engrailed 2 affects abundance EXP EN2 protein affects the abundance of Serotonin; EN2 protein affects the abundance of Serotonin metabolite CTD PMID:16935268 NCBI chr 5:28,370,694...28,377,195
Ensembl chr 5:28,370,692...28,377,164
JBrowse link
G Enam enamelin decreases expression EXP Serotonin results in decreased expression of ENAM mRNA CTD PMID:21083617 NCBI chr 5:88,635,834...88,653,908
Ensembl chr 5:88,635,834...88,653,908
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP [Serotonin co-treated with Dextran Sulfate] results in decreased expression of FAAH protein CTD PMID:30611738 NCBI chr 4:115,853,866...115,876,034
Ensembl chr 4:115,824,342...115,875,123
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Serotonin results in increased expression of FGF1 protein CTD PMID:15264218 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
JBrowse link
G Fgf5 fibroblast growth factor 5 affects uptake ISO FGF5 protein affects the uptake of Serotonin CTD PMID:8167846 NCBI chr 5:98,402,108...98,424,892
Ensembl chr 5:98,402,043...98,424,889
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Serotonin results in increased expression of FOS mRNA CTD PMID:10700011 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein CTD PMID:23009681 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Ghrl ghrelin decreases export ISO GHRL protein results in decreased export of Serotonin CTD PMID:20553917 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
JBrowse link
G Gla galactosidase, alpha affects response to substance EXP GLA protein affects the susceptibility to Serotonin CTD PMID:18565198 NCBI chr  X:133,488,912...133,501,707
Ensembl chr  X:133,488,898...133,501,874
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions EXP [Bile Acids and Salts binds to and results in increased activity of GPBAR1 protein] which results in increased secretion of Serotonin CTD PMID:23041323 NCBI chr 1:74,316,269...74,318,868
Ensembl chr 1:74,317,709...74,318,783
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Serotonin results in increased phosphorylation of GSK3B protein CTD PMID:20190034 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein] CTD PMID:26408985 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions
increases activity
affects binding
increases uptake
increases expression
affects response to substance
ISO
EXP
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]; Serotonin binds to and results in increased activity of HTR1A protein
Serotonin results in increased expression of HTR1A mRNA
HTR1A protein affects the susceptibility to Serotonin
CTD PMID:11106871 PMID:16528294 PMID:21083617 PMID:21126535 PMID:30102254 More... NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B affects binding
multiple interactions
ISO Serotonin binds to HTR1B protein
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1B protein]; Serotonin binds to and results in increased activity of HTR1B protein
CTD PMID:11888550 PMID:30102254 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
JBrowse link
G Htr1d 5-hydroxytryptamine (serotonin) receptor 1D affects abundance ISO HTR1D gene polymorphism affects the abundance of Serotonin CTD PMID:17203304 NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709
JBrowse link
G Htr1f 5-hydroxytryptamine (serotonin) receptor 1F multiple interactions ISO Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1F protein]; Serotonin binds to and results in increased activity of HTR1F protein CTD PMID:30102254 NCBI chr16:64,745,092...64,926,147
Ensembl chr16:64,745,092...64,926,217
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A decreases response to substance
affects response to substance
affects binding
increases expression
multiple interactions
ISO
EXP
HTR2A gene SNP results in decreased susceptibility to Serotonin
HTR2A protein affects the susceptibility to Serotonin
Serotonin binds to HTR2A protein
Serotonin results in increased expression of HTR2A mRNA
[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]
HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein
CTD PMID:8627522 PMID:11076827 PMID:11880652 PMID:16314884 PMID:16528294 More... NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B increases expression
affects binding
multiple interactions
affects response to substance
EXP
ISO
Serotonin results in increased expression of HTR2B mRNA
Serotonin binds to HTR2B protein
1-(5-fluoropentyl)-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [Serotonin binds to HTR2B protein]; 1-pentyl-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; JWH-073 inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; Serotonin binds to and results in increased activity of HTR2B protein
HTR2B protein affects the susceptibility to Serotonin
CTD PMID:8627522 PMID:9857084 PMID:21083617 PMID:27449567 NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects expression
multiple interactions
EXP
ISO
Serotonin affects the expression of HTR2C mRNA
[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]; Serotonin binds to and results in increased activity of HTR2C protein
CTD PMID:9050900 PMID:21083617 PMID:21554931 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273
JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A multiple interactions
increases activity
affects localization
ISO
EXP
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]
Serotonin results in increased activity of HTR3A protein
Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein]
Serotonin affects the localization of HTR3A protein alternative form
1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Toluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Trichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]
CTD PMID:12681521 PMID:17360702 PMID:17436349 PMID:32209479 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399
JBrowse link
G Htr3b 5-hydroxytryptamine (serotonin) receptor 3B multiple interactions ISO 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] CTD PMID:17360702 NCBI chr 9:48,846,308...48,876,290
Ensembl chr 9:48,846,308...48,876,290
JBrowse link
G Htr4 5 hydroxytryptamine (serotonin) receptor 4 multiple interactions EXP HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr18:62,456,618...62,636,098
Ensembl chr18:62,457,275...62,629,648
JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 multiple interactions EXP HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP] CTD PMID:11406289 PMID:11880652 NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
JBrowse link
G Il12b interleukin 12b affects secretion ISO Serotonin affects the secretion of IL12B protein CTD PMID:15802305 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il13 interleukin 13 affects response to substance EXP IL13 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions
increases expression
ISO
EXP
Serotonin affects the secretion of IL1B protein
anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]
Serotonin results in increased expression of IL1B
CTD PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il4 interleukin 4 affects response to substance EXP IL4 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 affects expression
multiple interactions
increases expression
affects secretion
ISO
EXP
Serotonin affects the expression of IL6 mRNA
anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]
Serotonin results in increased expression of IL6 mRNA
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein
Serotonin affects the secretion of IL6 protein
CTD PMID:11076827 PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
JBrowse link
G Itga2 integrin alpha 2 multiple interactions EXP
ISO
ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]
CTD PMID:18234883 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636
JBrowse link
G Itgam integrin alpha M increases expression EXP Serotonin increases expression of Itgam protein on neutrophils RGD PMID:30586717 RGD:329853774 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb3 integrin beta 3 affects abundance ISO ITGB3 gene polymorphism affects the abundance of Serotonin CTD PMID:16724005 PMID:17203304 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Kcnk3 potassium channel, subfamily K, member 3 multiple interactions ISO Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium] CTD PMID:16020457 NCBI chr 5:30,745,514...30,782,614
Ensembl chr 5:30,745,514...30,782,615
JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334 PMID:12791437 PMID:18234883 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
JBrowse link
G Maoa monoamine oxidase A increases metabolic processing
multiple interactions
increases degradation
decreases amination
increases abundance
ISO
EXP
MAOA protein results in increased metabolism of Serotonin
[MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid
MAOA protein results in increased degradation of Serotonin
[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde; Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]; Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]
MAOA protein results in decreased amination of Serotonin
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Isocarboxazid inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
MAOA mutant form results in increased abundance of Serotonin
MAOA gene polymorphism results in increased abundance of Serotonin
CTD PMID:3961266 PMID:10647887 PMID:11834493 PMID:18405062 PMID:23009399 More... NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Maob monoamine oxidase B increases abundance
decreases amination
multiple interactions
EXP
ISO
MAOB mutant form results in increased abundance of Serotonin
MAOB protein results in decreased amination of Serotonin
3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]
CTD PMID:11834493 PMID:26721607 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK1 protein CTD PMID:30592962 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK3 protein CTD PMID:30592962 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mmp20 matrix metallopeptidase 20 (enamelysin) decreases expression EXP Serotonin results in decreased expression of MMP20 mRNA CTD PMID:21083617 NCBI chr 9:7,628,232...7,674,969
Ensembl chr 9:7,628,232...7,674,980
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine]
glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]
CTD PMID:23009681 PMID:30611738 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin CTD PMID:18226494 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP [MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin CTD PMID:18226494 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein] CTD PMID:30611738 NCBI chr 5:21,867,899...21,906,620
Ensembl chr 5:21,867,899...21,906,394
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
JBrowse link
G Otc ornithine transcarbamylase affects metabolic processing
multiple interactions
EXP OTC gene mutant form affects the metabolism of Serotonin
Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]
CTD PMID:3374991 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263
JBrowse link
G Oxt oxytocin increases secretion EXP OXT protein results in increased secretion of Serotonin CTD PMID:19228979 NCBI chr 2:130,416,432...130,418,974
Ensembl chr 2:130,418,093...130,418,974
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 affects abundance ISO PARP1 affects the abundance of Serotonin CTD PMID:21990073 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Penk preproenkephalin multiple interactions ISO Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] CTD PMID:1363325 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases localization
multiple interactions
ISO Serotonin results in increased localization of PPARG protein
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein]
CTD PMID:25766885 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions
increases phosphorylation
decreases phosphorylation
EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP
ISO
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
Serotonin results in increased expression of PTGS2 mRNA; Serotonin results in increased expression of PTGS2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; AG 1879 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; Calcium deficiency inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
CTD PMID:21262218 PMID:26408985 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases activity ISO Serotonin results in increased activity of RELA protein CTD PMID:11076827 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 multiple interactions EXP [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897
JBrowse link
G Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 multiple interactions
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects binding
increases uptake
increases transport
multiple interactions
affects uptake
ISO Serotonin binds to SLC18A2 protein
Serotonin binds to Slc8a2 protein
SLC18A2 protein binds to Serotonin
SLC18A2 protein results in increased uptake of Serotonin
SLC18A2 protein results in increased transport of Serotonin
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]
SLC18A2 gene SNP affects the uptake of Serotonin
CTD
RGD
PMID:1438304 PMID:7912402 PMID:9038139 PMID:15475732 PMID:18287335 More... RGD:5130957 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc22a16 solute carrier family 22 (organic cation transporter), member 16 multiple interactions ISO Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr10:40,446,317...40,480,128
Ensembl chr10:40,446,332...40,480,128
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions
increases uptake
ISO Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Serotonin
CTD PMID:9830022 PMID:16928864 PMID:20858707 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
JBrowse link
G Slc29a4 solute carrier family 29 (nucleoside transporters), member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Serotonin CTD PMID:20858707 NCBI chr 5:142,678,226...142,708,245
Ensembl chr 5:142,678,267...142,708,245
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Serotonin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
increases uptake
ISO SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Serotonin
CTD PMID:17234900 PMID:17250655 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 multiple interactions
increases activity
decreases activity
increases uptake
affects binding
increases expression
affects abundance
ISO
EXP
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
serotonin decreases activity of Slc6a4 protein in epithelial colorectal adenocarcinoma cells
Serotonin binds to SLC6A4 protein
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Aminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Dextroamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]
Serotonin results in increased expression of SLC6A4 mRNA
SLC6A4 gene polymorphism affects the abundance of Serotonin
CTD
RGD
PMID:15972295 PMID:16272152 PMID:16476009 PMID:16982082 PMID:17203304 More... RGD:36947380 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing multiple interactions
increases expression
ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
JBrowse link
G Stxbp3 syntaxin binding protein 3 affects secretion ISO STXBP3 protein affects the secretion of Serotonin CTD PMID:18556422 NCBI chr 3:108,700,496...108,747,818
Ensembl chr 3:108,700,492...108,747,842
JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 increases sulfation EXP SULT1A1 protein results in increased sulfation of Serotonin CTD PMID:11181495 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054
JBrowse link
G Taar1 trace amine-associated receptor 1 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367
JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334 PMID:18234883 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin CTD PMID:16952380 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor affects secretion
multiple interactions
increases expression
ISO
EXP
Serotonin affects the secretion of TNF protein
[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein; anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]; glyceryl 2-arachidonate inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]
Serotonin results in increased expression of TNF
CTD PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tph1 tryptophan hydroxylase 1 affects abundance
multiple interactions
increases chemical synthesis
increases abundance
ISO
EXP
TPH1 gene polymorphism affects the abundance of Serotonin
Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]]; Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]
TPH1 protein results in increased chemical synthesis of Serotonin
TPH1 gene polymorphism results in increased abundance of Serotonin
CTD PMID:17203304 PMID:18405062 PMID:18506000 PMID:30611738 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
JBrowse link
G Tph2 tryptophan hydroxylase 2 affects abundance EXP TPH2 protein affects the abundance of Serotonin CTD PMID:20722968 NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin] CTD PMID:19507004 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:16901936 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions EXP TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] CTD PMID:18234883 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions
affects glucuronidation
increases glucuronidation
ISO bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]
UGT1A6 gene polymorphism affects the glucuronidation of Serotonin; UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite
UGT1A6 protein results in increased glucuronidation of Serotonin; UGT1A6 protein results in increased glucuronidation of Serotonin metabolite
CTD PMID:15761113 PMID:15761114 PMID:18214896 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein; sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] CTD PMID:23009681 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide multiple interactions EXP [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 2:163,837,082...163,860,508
Ensembl chr 2:163,836,880...163,860,508
JBrowse link
serpentine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity
ISO serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
serpentine (alkaloid) results in decreased activity of CYP2D6 protein
CTD PMID:15930738 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
staurosporine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO Staurosporine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Ache acetylcholinesterase increases activity
increases expression
multiple interactions
ISO Staurosporine results in increased activity of ACHE protein
Staurosporine results in increased expression of ACHE protein alternative form
ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]
CTD PMID:20338155 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Adm adrenomedullin decreases expression ISO Staurosporine results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
Staurosporine results in increased phosphorylation of AKT1 protein
Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:11306697 PMID:15177934 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 PMID:18001288 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Ar androgen receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Atg12 autophagy related 12 affects response to substance ISO ATG12 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647
JBrowse link
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 decreases expression ISO Staurosporine results in decreased expression of ATP2A2 mRNA CTD PMID:10625299 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288
JBrowse link
G Bag3 BCL2-associated athanogene 3 decreases response to substance
decreases expression
multiple interactions
ISO BAG3 protein results in decreased susceptibility to Staurosporine
Staurosporine results in decreased expression of BAG3 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]; Staurosporine results in increased degradation of and results in increased ubiquitination of BAG3 protein
CTD PMID:19352495 NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705
JBrowse link
G Bag4 BCL2-associated athanogene 4 decreases expression ISO Staurosporine results in decreased expression of BAG4 protein CTD PMID:19352495 NCBI chr 8:26,254,566...26,275,237
Ensembl chr 8:26,254,566...26,275,315
JBrowse link
G Bag6 BCL2-associated athanogene 6 decreases expression ISO Staurosporine results in decreased expression of BAG6 protein CTD PMID:19352495 NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298
JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects localization
affects expression
increases expression
ISO
EXP
Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]]; Staurosporine affects the folding of and results in increased activity of BAX protein; Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]; Staurosporine promotes the reaction [BID protein binds to BAX protein]; Staurosporine results in increased activity of and results in increased expression of BAX protein
Staurosporine affects the localization of BAX protein
Staurosporine affects the expression of BAX mRNA
Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]
CTD PMID:11296547 PMID:12579951 PMID:15961378 PMID:16007140 PMID:19552762 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]; Staurosporine inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein] CTD PMID:15907805 PMID:35158046 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases response to substance
increases expression
affects expression
ISO
EXP
BCL2L1 protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased expression of BCL2L1 protein alternative form
Staurosporine affects the expression of BCL2L1 mRNA
BCL2L1 gene mutant form results in decreased susceptibility to Staurosporine
CTD PMID:10679475 PMID:10970895 PMID:11296547 PMID:11468182 PMID:21256112 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
decreases response to substance
ISO 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine] CTD PMID:16497721 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions
ISO Staurosporine results in increased expression of BID protein
Staurosporine promotes the reaction [BID protein binds to BAX protein]
CTD PMID:19552762 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance ISO BIRC3 protein results in decreased susceptibility to Staurosporine CTD PMID:16144937 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Staurosporine results in decreased expression of BIRC5 protein CTD PMID:16225760 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase affects expression EXP Staurosporine affects the expression of BUB1B mRNA CTD PMID:15721199 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
affects localization
ISO Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] CTD PMID:16927020 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp2 caspase 2 increases cleavage ISO Staurosporine results in increased cleavage of CASP2 protein CTD PMID:10663630 PMID:26124276 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases secretion
increases activity
ISO
EXP
Acetaminophen promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP3 protein; Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Staurosporine results in increased secretion of CASP3 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; nimesulide inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
CTD PMID:10663630 PMID:11296547 PMID:12556443 PMID:12871656 PMID:15909127 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp6 caspase 6 increases cleavage ISO Staurosporine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
increases cleavage
increases activity
ISO EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine results in increased expression of CASP7 protein modified form
Staurosporine results in increased cleavage of CASP7 protein
DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form]
CTD PMID:16402917 PMID:18832097 PMID:19352495 PMID:19406941 PMID:21864672 More... NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP8 protein
Staurosporine results in increased activity of CASP8 protein
CTD PMID:16007152 PMID:19352495 PMID:24658017 PMID:29458164 PMID:31926150 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP9 protein
Staurosporine results in increased cleavage of CASP9 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]
CTD PMID:16007152 PMID:16497721 PMID:19352495 PMID:20338155 PMID:26124276 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] CTD PMID:12594210 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Cd28 CD28 antigen multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO Staurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein] CTD PMID:16618747 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
affects binding
ISO Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]; Staurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
Staurosporine binds to CHRM1 protein
CTD PMID:10860942 PMID:16439611 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding ISO Staurosporine binds to CHRM3 protein CTD PMID:12435818 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO CSF2 protein affects the susceptibility to [Nitroblue Tetrazolium co-treated with Staurosporine] CTD PMID:8471626 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Csn2 casein beta multiple interactions EXP Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr 5:87,840,478...87,847,288
Ensembl chr 5:87,840,483...87,847,489
JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide multiple interactions ISO Staurosporine affects the reaction [Formaldehyde affects the phosphorylation of CSNK2A1 protein] CTD PMID:36534342 NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772
JBrowse link
G Csnk2a2 casein kinase 2, alpha prime polypeptide affects expression EXP Staurosporine affects the expression of CSNK2A2 mRNA CTD PMID:15721199 NCBI chr 8:96,172,724...96,215,505
Ensembl chr 8:96,172,724...96,216,667
JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation ISO Staurosporine results in increased phosphorylation of CTNNB1 protein CTD PMID:19741129 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein] CTD PMID:8969274 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]; Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CYBB protein] CTD PMID:29183754 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; Staurosporine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]
CTD PMID:1312672 PMID:7587946 PMID:9395520 PMID:10696073 PMID:15947024 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions ISO Staurosporine inhibits the reaction [Ethanol results in increased expression of CYP2A6 mRNA]; Staurosporine inhibits the reaction [Ethanol results in increased expression of CYP2A6 protein] CTD PMID:22530035 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Staurosporine results in increased expression of CYP2E1 mRNA
CTD PMID:11306697 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Staurosporine results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dedd death effector domain-containing affects expression EXP Staurosporine affects the expression of DEDD mRNA CTD PMID:15721199 NCBI chr 1:171,152,229...171,170,843
Ensembl chr 1:171,156,713...171,169,899
JBrowse link
G Dock1 dedicator of cytokinesis 1 multiple interactions ISO DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr 7:134,272,416...134,775,376
Ensembl chr 7:134,272,383...134,775,368
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
decreases expression
ISO Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein]
Staurosporine results in decreased expression of MBF1 protein
CTD PMID:12729799 NCBI chr 2:25,447,838...25,452,096
Ensembl chr 2:25,447,859...25,452,094
JBrowse link
G Edn1 endothelin 1 decreases activity ISO Staurosporine results in decreased activity of EDN1 protein CTD PMID:15464066 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein] CTD PMID:20561571 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
CTD PMID:15542774 PMID:19406941 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases activity ISO Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation EXP Staurosporine results in increased phosphorylation of EIF2S1 protein CTD PMID:21090173 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Elmo1 engulfment and cell motility 1 multiple interactions ISO ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523
JBrowse link
G Eomes eomesodermin multiple interactions ISO EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form] CTD PMID:27539959 NCBI chr 9:118,307,259...118,315,176
Ensembl chr 9:118,307,280...118,315,200
JBrowse link
G Epo erythropoietin decreases response to substance
multiple interactions
ISO EPO protein results in decreased susceptibility to Staurosporine
tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]
CTD PMID:15816862 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Ercc5 excision repair cross-complementing rodent repair deficiency, complementation group 5 affects expression EXP Staurosporine affects the expression of ERCC5 mRNA CTD PMID:15721199 NCBI chr 1:44,184,084...44,220,399
Ensembl chr 1:44,186,904...44,220,420
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G F3 coagulation factor III multiple interactions ISO Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA] CTD PMID:15371228 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fermt2 fermitin family member 2 affects expression EXP Staurosporine affects the expression of FERMT2 mRNA CTD PMID:15721199 NCBI chr14:45,696,252...45,767,767
Ensembl chr14:45,696,252...45,767,575
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7945571 PMID:9417049 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLM promoter] CTD PMID:17628013 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Staurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:66,005,826...66,019,670
Ensembl chr18:66,005,891...66,019,667
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) multiple interactions ISO Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of GSTA2 protein] CTD PMID:7587946 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
Staurosporine inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein]
Staurosporine results in increased expression of HMOX1 protein
SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]
CTD PMID:12788823 PMID:18048804 PMID:23290930 PMID:24740755 PMID:28108387 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hr lysine demethylase and nuclear receptor corepressor multiple interactions
affects response to substance
EXP
ISO
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
HR protein affects the susceptibility to Staurosporine
CTD PMID:20886113 NCBI chr14:70,789,644...70,810,988
Ensembl chr14:70,789,652...70,810,988
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
affects activity
ISO IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine affects the activity of IGF1 protein
CTD PMID:11548882 PMID:19406941 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Staurosporine results in increased expression of IL33 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Staurosporine results in increased expression of IL33 protein]
CTD PMID:25747661 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]] CTD PMID:9766631 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il5 interleukin 5 decreases activity ISO Staurosporine results in decreased activity of IL5 protein CTD PMID:12562334 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO
Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]
Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:7648427 PMID:11306697 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ins2 insulin II multiple interactions ISO Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Itgal integrin alpha L multiple interactions EXP Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
JBrowse link
G Itgam integrin alpha M multiple interactions ISO Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases phosphorylation
ISO Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA]
Staurosporine results in increased phosphorylation of JUN protein
CTD PMID:7945571 PMID:9751194 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kng1 kininogen 1 decreases activity ISO Staurosporine results in decreased activity of KNG1 CTD PMID:1334751 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
JBrowse link
G Lmna lamin A increases cleavage ISO Staurosporine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mark1 MAP/microtubule affinity regulating kinase 1 multiple interactions ISO Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein] CTD PMID:10737602 NCBI chr 1:184,628,621...184,732,152
Ensembl chr 1:184,628,986...184,731,767
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 increases cleavage
decreases response to substance
ISO Staurosporine results in increased cleavage of MCL1 protein
MCL1 results in decreased susceptibility to Staurosporine
CTD PMID:15217956 PMID:16007152 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions ISO Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein] CTD PMID:16251475 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:15142038 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
decreases response to substance
ISO MYC protein inhibits the reaction [Staurosporine results in increased abundance of Reactive Oxygen Species]; Staurosporine promotes the reaction [MYC protein binds to GCLC promoter]; Staurosporine promotes the reaction [MYC protein binds to GCLM promoter]
MYC protein results in decreased susceptibility to Staurosporine
CTD PMID:17628013 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nefm neurofilament, medium polypeptide multiple interactions ISO Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases expression
ISO Staurosporine inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]; Staurosporine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
Staurosporine results in decreased expression of NFE2L2 protein modified form
CTD PMID:22530035 PMID:30703377 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Staurosporine inhibits the reaction [bisphenol A results in increased expression of NFKB1 protein] CTD PMID:20499049 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Ngf nerve growth factor multiple interactions EXP
ISO
Staurosporine inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
Staurosporine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD PMID:1374475 PMID:12815188 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein] CTD PMID:14534150 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein] CTD PMID:12729799 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]
Staurosporine inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD PMID:7587946 PMID:28108387 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions ISO Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [methylhistaprodifen results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Neurotransmitter Agents results in increased expression of NTF3 protein] CTD PMID:19854260 PMID:21276809 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein] CTD PMID:15177934 PMID:18313772 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases expression
increases cleavage
EXP
ISO
SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Staurosporine results in increased expression of PARP1 protein modified form
EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]
CTD PMID:10704466 PMID:11035063 PMID:18451153 PMID:21447800 PMID:22639866 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP [Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein] CTD PMID:23293585 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta affects localization ISO Staurosporine affects the localization of PPP2R2B protein CTD PMID:18940801 NCBI chr18:42,777,811...43,192,827
Ensembl chr18:42,770,497...43,216,192
JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform decreases response to substance
increases cleavage
EXP
ISO
PPP3CA protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased cleavage of PPP3CA protein
CTD PMID:10679475 PMID:10898953 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions EXP Staurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Staurosporine affects the localization of and affects the activity of PRKCA protein
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]
CTD PMID:11994256 PMID:14678745 PMID:16225760 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]
CTD PMID:14678745 PMID:17171638 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prl prolactin multiple interactions EXP Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) multiple interactions
decreases phosphorylation
ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]
Staurosporine results in decreased phosphorylation of PTGER3 protein alternative form
CTD PMID:15937517 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO Staurosporine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] CTD PMID:17003101 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Staurosporine inhibits the reaction [bisphenol A results in increased expression of RELA protein]
CTD PMID:20499049 PMID:24021941 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ret ret proto-oncogene decreases expression ISO Staurosporine results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679
JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) multiple interactions EXP [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein] CTD PMID:23293585 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
JBrowse link
G Set SET nuclear oncogene multiple interactions ISO Staurosporine affects the reaction [Formaldehyde affects the localization of SET protein alternative form] CTD PMID:36534342 NCBI chr 2:29,952,074...29,962,589
Ensembl chr 2:29,947,390...29,962,589
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 decreases phosphorylation
multiple interactions
EXP Staurosporine results in decreased phosphorylation of SLC11A2 protein
[Staurosporine results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron
CTD PMID:27681840 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953
JBrowse link
G Slc12a5 solute carrier family 12, member 5 increases activity
multiple interactions
ISO Staurosporine results in increased activity of SLC12A5 protein
Staurosporine inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651
JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 multiple interactions
decreases activity
ISO Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
Staurosporine results in decreased activity of SLC1A1 protein
CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 multiple interactions ISO Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
JBrowse link
G Slc22a19 solute carrier family 22 (organic anion transporter), member 19 multiple interactions ISO Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein] CTD PMID:17341544 NCBI chr19:7,650,440...7,688,675
Ensembl chr19:7,650,426...7,688,675
JBrowse link
G Slc30a1 solute carrier family 30 (zinc transporter), member 1 multiple interactions EXP Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359
JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 multiple interactions ISO Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 increases activity
multiple interactions
ISO Staurosporine results in increased activity of SLC6A3 protein
SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein]
CTD PMID:19032594 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 increases activity ISO staurosporine increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:7615516 RGD:38500207 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 PMID:19114014 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein] CTD PMID:23293585 PMID:24740755 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 multiple interactions
increases cleavage
EXP
ISO
Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
Staurosporine results in increased cleavage of SPTAN1 protein
CTD PMID:18182247 PMID:21683092 PMID:26124276 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of SYNCRIP protein] CTD PMID:19331829 NCBI chr 9:88,331,417...88,364,645
Ensembl chr 9:88,329,062...88,364,627
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Staurosporine results in decreased activity of TERT protein CTD PMID:9434777 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Staurosporine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Staurosporine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Staurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 multiple interactions
increases expression
ISO Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Ionomycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]; Staurosporine promotes the reaction [Mercuric Chloride results in increased expression of TNFRSF4 protein]
Staurosporine results in increased expression of TNFRSF4 protein
CTD PMID:9766631 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]
TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
CTD PMID:15542774 PMID:20886113 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]] CTD PMID:18182247 NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases cleavage ISO Staurosporine results in increased cleavage of VDR protein CTD PMID:18832097 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Staurosporine inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein] CTD PMID:12788823 PMID:14704231 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin multiple interactions ISO Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Staurosporine results in increased expression of WT1 protein CTD PMID:12914969 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961
JBrowse link
strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO Strychnine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac affects binding
multiple interactions
ISO Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9495826 PMID:15647330 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding ISO Strychnine binds to CHRM3 protein CTD PMID:12435818 PMID:15647330 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9495826 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Strychnine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Strychnine results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions
decreases activity
ISO
EXP
Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Strychnine results in decreased activity of GLRA1 protein
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]
CTD PMID:7752562 PMID:15081878 PMID:16687139 PMID:20719748 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024
JBrowse link
G Glra2 glycine receptor, alpha 2 subunit decreases activity ISO Strychnine results in decreased activity of GLRA2 protein CTD PMID:7752562 NCBI chr  X:163,912,013...164,110,863
Ensembl chr  X:163,912,013...164,110,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha multiple interactions ISO Strychnine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
sumatriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of BDNF protein] CTD PMID:22150557 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
decreases expression
ISO Sumatriptan results in decreased expression of and results in decreased secretion of CALCA protein
Sumatriptan results in decreased expression of CALCA mRNA
3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; isamoltane inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]
CTD PMID:12574409 PMID:14715155 PMID:15689192 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein] CTD PMID:29958920 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CCL2 protein] CTD PMID:22150557 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein] CTD PMID:22150557 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein] CTD PMID:22150557 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL3 protein] CTD PMID:22150557 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCR4 protein] CTD PMID:22150557 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984
JBrowse link
G Cd80 CD80 antigen multiple interactions ISO [Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein] CTD PMID:22150557 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cilk1 ciliogenesis associated kinase 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CILK1 protein] CTD PMID:22150557 NCBI chr 9:78,016,425...78,079,396
Ensembl chr 9:78,016,474...78,079,389
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein] CTD PMID:22150557 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996
JBrowse link
G Cntfr ciliary neurotrophic factor receptor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTFR protein] CTD PMID:22150557 NCBI chr 4:41,657,498...41,697,091
Ensembl chr 4:41,657,498...41,697,089
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CSF2 protein] CTD PMID:22150557 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein] CTD PMID:22150557 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein] CTD PMID:22150557 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein] CTD PMID:22150557 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein] CTD PMID:22150557 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein] CTD PMID:22150557 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein] CTD PMID:22150557 NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein] CTD PMID:22150557 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FAS protein] CTD PMID:22150557 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FASLG protein] CTD PMID:22150557 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein] CTD PMID:22150557 NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121
JBrowse link
G Fgl1 fibrinogen-like protein 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FGL1 protein] CTD PMID:22150557 NCBI chr 8:41,644,471...41,671,015
Ensembl chr 8:41,644,471...41,668,193
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FOS protein] CTD PMID:12110114 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein] CTD PMID:22150557 NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876
JBrowse link
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein] CTD PMID:22150557 NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341
JBrowse link
G Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA2 protein] CTD PMID:22150557 NCBI chr14:71,127,547...71,217,280
Ensembl chr14:71,127,560...71,217,278
JBrowse link
G Gh growth hormone multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein] CTD PMID:22150557 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
JBrowse link
G Ghr growth hormone receptor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein] CTD PMID:22150557 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974
JBrowse link
G Hcrt hypocretin multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein] CTD PMID:22150557 NCBI chr11:100,652,519...100,653,757
Ensembl chr11:100,651,895...100,653,757
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B multiple interactions
affects binding
ISO Sumatriptan binds to and results in increased activity of HTR1B protein
Sumatriptan binds to HTR1B protein
CTD PMID:11301495 PMID:11888550 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
JBrowse link
G Htr1d 5-hydroxytryptamine (serotonin) receptor 1D multiple interactions ISO Sumatriptan binds to and results in increased activity of HTR1D protein CTD PMID:11301495 NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709
JBrowse link
G Ide insulin degrading enzyme multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein] CTD PMID:22150557 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IFNG protein] CTD PMID:22150557 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL10 protein] CTD PMID:22150557 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein] CTD PMID:22150557 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IL1A protein] CTD PMID:22150557 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of IL1B mRNA] CTD PMID:22150557 PMID:29958920 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL2 protein] CTD PMID:22150557 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il3 interleukin 3 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein] CTD PMID:22150557 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL4 protein] CTD PMID:22150557 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL5 protein] CTD PMID:22150557 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:22150557 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inhba inhibin beta-A multiple interactions ISO Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INHBA protein] CTD PMID:22150557 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Ins1 insulin I multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INS1 protein] CTD PMID:22150557 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Lep leptin multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein] CTD PMID:22150557 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein] CTD PMID:22150557 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP2 protein] CTD PMID:22150557 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Musk muscle, skeletal, receptor tyrosine kinase multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein] CTD PMID:22150557 NCBI chr 4:58,285,742...58,377,848
Ensembl chr 4:58,285,962...58,374,303
JBrowse link
G Ngf nerve growth factor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA] CTD PMID:12574409 PMID:22150557 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein] CTD PMID:22150557 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein] CTD PMID:14510930 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Sumatriptan results in decreased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein] CTD PMID:22150557 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844
JBrowse link
G Pdgfa platelet derived growth factor, alpha multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein] CTD PMID:22150557 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125
JBrowse link
G Plin2 perilipin 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of PLIN2 protein] CTD PMID:22150557 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
JBrowse link
G Pomc pro-opiomelanocortin-alpha decreases expression
multiple interactions
ISO Sumatriptan results in decreased expression of POMC protein modified form
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]
CTD PMID:7640145 PMID:22150557 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein] CTD PMID:22150557 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prlr prolactin receptor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of PRLR protein] CTD PMID:22150557 NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266
JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein] CTD PMID:22150557 NCBI chr 3:107,139,232...107,147,023
Ensembl chr 3:107,140,113...107,147,023
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Sumatriptan inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein] CTD PMID:29958920 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Retn resistin multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETN protein] CTD PMID:22150557 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110
JBrowse link
G Retnlb resistin like beta multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETNLB protein] CTD PMID:22150557 NCBI chr16:48,637,219...48,639,255
Ensembl chr16:48,637,219...48,639,255
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELE protein] CTD PMID:22150557 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Sell selectin, lymphocyte multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein] CTD PMID:22150557 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Sumatriptan promotes the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Tal1 T cell acute lymphocytic leukemia 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TAL1 protein] CTD PMID:22150557 NCBI chr 4:114,913,623...114,928,952
Ensembl chr 4:114,913,623...114,928,952
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein] CTD PMID:22150557 NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein] CTD PMID:22150557 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein] CTD PMID:22150557 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein] CTD PMID:22150557 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein] CTD PMID:22150557 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein] CTD PMID:22150557 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein] CTD PMID:22150557 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of TNF mRNA] CTD PMID:22150557 PMID:29958920 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein] CTD PMID:22150557 NCBI chr14:61,201,283...61,284,304
Ensembl chr14:61,201,324...61,283,939
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein] CTD PMID:22150557 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein] CTD PMID:22150557 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of VEGFA protein] CTD PMID:22150557 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Zfp997 zinc finger protein 997 multiple interactions ISO [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein] CTD PMID:22150557 NCBI chr13:66,258,188...66,271,523
Ensembl chr13:66,261,294...66,271,953
JBrowse link
Syrosingopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO syrosingopine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
tryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
decreases activity
ISO [tryptamine results in decreased activity of CYP2A6 protein] which results in decreased abundance of Cotinine; [tryptamine results in decreased activity of CYP2A6 protein] which results in decreased abundance of Nicotine metabolite CTD PMID:11353760 PMID:22498344 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Gast gastrin decreases cleavage ISO tryptamine results in decreased cleavage of GAST protein CTD PMID:10332097 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A decreases response to substance
affects response to substance
multiple interactions
ISO HTR2A gene SNP results in decreased susceptibility to tryptamine
HTR2A protein affects the susceptibility to tryptamine
tryptamine binds to and results in increased activity of HTR2A protein
CTD PMID:16314884 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Maoa monoamine oxidase A decreases amination
multiple interactions
ISO MAOA protein results in decreased amination of tryptamine
[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde
CTD PMID:26686552 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases amination
ISO [[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde CTD PMID:26686552 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tryptamine results in increased activity of NR1I2 protein CTD PMID:33002526 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Taar1 trace amine-associated receptor 1 multiple interactions
increases activity
ISO
EXP
[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367
JBrowse link
vincaleukoblastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 9530068E07Rik RIKEN cDNA 9530068E07 gene affects response to substance ISO C5ORF15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:52,287,255...52,299,550
Ensembl chr11:52,287,255...52,299,555
JBrowse link
G Abca2 ATP-binding cassette, sub-family A member 2 decreases response to substance
increases expression
ISO ABCA2 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA2 mRNA
CTD PMID:16928819 NCBI chr 2:25,318,611...25,338,556
Ensembl chr 2:25,318,715...25,338,552
JBrowse link
G Abca3 ATP-binding cassette, sub-family A member 3 decreases response to substance
increases expression
ISO ABCA3 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA3 mRNA
CTD PMID:16928819 NCBI chr17:24,570,997...24,629,178
Ensembl chr17:24,570,924...24,629,175
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases uptake
decreases activity
multiple interactions
increases export
EXP
ISO
ABCB11 protein results in decreased uptake of Vinblastine
Vinblastine results in decreased activity of ABCB11 protein
Vinblastine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ABCB11 protein results in increased export of Vinblastine
CTD PMID:10617675 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects uptake
decreases response to substance
affects binding
increases transport
increases secretion
increases activity
increases expression
multiple interactions
ISO
EXP
ABCB1 protein affects the uptake of Vinblastine
ABCB1 protein results in decreased susceptibility to Vinblastine
Vinblastine binds to ABCB1 protein
ABCB1 protein results in increased transport of Vinblastine
ABCB1A protein results in increased secretion of Vinblastine
Vinblastine results in increased activity of ABCB1 protein mutant form
ABCB1 protein results in increased secretion of Vinblastine
Vinblastine results in increased expression of ABCB1 protein
[Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [sodium arsenite results in increased expression of ABCB1 protein] which results in decreased susceptibility to Vinblastine; [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; cnidiadin inhibits the reaction [ABCB1 protein results in increased export of Vinblastine]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]
CTD PMID:1967174 PMID:8917702 PMID:9148857 PMID:11355955 PMID:11455017 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases secretion ISO ABCB1B protein results in increased secretion of Vinblastine CTD PMID:12235267 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects response to substance
decreases response to substance
ISO ABCC1 protein affects the susceptibility to Vinblastine
ABCC1 protein results in decreased susceptibility to Vinblastine
CTD PMID:9334814 PMID:11455017 PMID:16156793 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects transport
decreases response to substance
multiple interactions
ISO ABCC2 protein affects the transport of Vinblastine
ABCC2 protein results in decreased susceptibility to Vinblastine
[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]
CTD PMID:9525973 PMID:11455017 PMID:15849751 PMID:25844889 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Ablim1 actin-binding LIM protein 1 affects response to substance ISO ABLIM1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:57,021,165...57,303,776
Ensembl chr19:57,021,165...57,303,351
JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 affects response to substance ISO ACAT2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
JBrowse link
G Acot13 acyl-CoA thioesterase 13 affects response to substance ISO ACOT13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:25,001,938...25,015,472
Ensembl chr13:25,001,931...25,015,523
JBrowse link
G Acp1 acid phosphatase 1, soluble affects response to substance ISO ACP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588
JBrowse link
G Add3 adducin 3 affects response to substance ISO ADD3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:53,128,874...53,235,518
Ensembl chr19:53,128,874...53,235,830
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression ISO Vinblastine results in decreased expression of AIF1 mRNA CTD PMID:20624997 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Vinblastine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070
JBrowse link
G Aox1 aldehyde oxidase 1 affects response to substance ISO AOX1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:58,068,963...58,145,569
Ensembl chr 1:58,069,090...58,145,572
JBrowse link
G Apln apelin decreases expression ISO Vinblastine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730
JBrowse link
G Atp5me ATP synthase membrane subunit e affects response to substance ISO ATP5ME protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:108,581,112...108,582,265
Ensembl chr 5:108,581,110...108,582,314
JBrowse link
G Atp5mf ATP synthase membrane subunit f affects response to substance ISO ATP5MF protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:145,120,514...145,128,351
Ensembl chr 5:145,120,508...145,128,872
JBrowse link
G Aurkb aurora kinase B affects response to substance ISO AURKB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
JBrowse link
G Axl AXL receptor tyrosine kinase affects response to substance ISO AXL protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects response to substance ISO BIRC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects response to substance ISO BIRC3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 decreases response to substance ISO BIRC7 protein results in decreased susceptibility to Vinblastine CTD PMID:17437058 NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase affects response to substance ISO BUB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO Vinblastine results in increased cleavage of CASP3 protein
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]
CTD PMID:16545138 PMID:20624997 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Vinblastine results in increased expression of CCL2 mRNA CTD PMID:20624997 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccn2 cellular communication network factor 2 affects response to substance ISO CCN2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Ccnb1 cyclin B1 affects response to substance
increases response to substance
ISO CCNB1 protein affects the susceptibility to Vinblastine
CCNB1 protein results in increased susceptibility to Vinblastine
CTD PMID:16217747 PMID:16849574 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnb2 cyclin B2 affects response to substance ISO CCNB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Cd14 CD14 antigen increases expression ISO Vinblastine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd40lg CD40 ligand decreases response to substance
multiple interactions
ISO CD40LG protein results in decreased susceptibility to Vinblastine
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CTD PMID:16545138 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
G Cd44 CD44 antigen increases expression ISO Vinblastine results in increased expression of CD44 mRNA CTD PMID:20624997 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Cdca8 cell division cycle associated 8 affects response to substance ISO CDCA8 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
JBrowse link
G Cdk1 cyclin dependent kinase 1 affects response to substance ISO CDK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects response to substance ISO CDK2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Vinblastine results in increased expression of CDKN1A mRNA CTD PMID:20624997 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects response to substance ISO CDKN2C protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 decreases expression ISO Vinblastine results in decreased expression of CDKN3 mRNA CTD PMID:20624997 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
JBrowse link
G Cenpa centromere protein A affects response to substance ISO CENPA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174
JBrowse link
G Ckap2 cytoskeleton associated protein 2 affects response to substance ISO CKAP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:22,658,168...22,675,835
Ensembl chr 8:22,658,176...22,675,835
JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone affects response to substance ISO COX17 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A affects response to substance ISO COX5A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709
JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 affects response to substance ISO COX6B1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576
JBrowse link
G Cp ceruloplasmin increases expression ISO Vinblastine results in increased expression of CP mRNA CTD PMID:20624997 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 affects response to substance ISO CREG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:165,591,327...165,602,878
Ensembl chr 1:165,591,315...165,602,877
JBrowse link
G Cript cysteine-rich PDZ-binding protein affects response to substance ISO CRIPT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:87,332,989...87,343,236
Ensembl chr17:87,332,978...87,343,238
JBrowse link
G Ctss cathepsin S increases expression ISO Vinblastine results in increased expression of CTSS mRNA CTD PMID:20624997 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 affects response to substance
increases stability
multiple interactions
ISO CXCL8 protein affects the susceptibility to Vinblastine
Vinblastine results in increased stability of CXCL8 mRNA
Paclitaxel inhibits the reaction [Vinblastine results in increased stability of CXCL8 mRNA]
CTD PMID:16217747 PMID:16499908 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Vinblastine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:11602686 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Dcps decapping enzyme, scavenger affects response to substance ISO DCPS protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:35,035,710...35,087,283
Ensembl chr 9:35,035,704...35,087,357
JBrowse link
G Ddx23 DEAD box helicase 23 affects response to substance ISO DDX23 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:98,543,012...98,560,808
Ensembl chr15:98,543,015...98,560,775
JBrowse link
G Dera deoxyribose-phosphate aldolase affects response to substance ISO DERA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:137,731,093...137,814,894
Ensembl chr 6:137,731,544...137,834,338
JBrowse link
G Dffb DNA fragmentation factor, beta subunit affects response to substance ISO DFFB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583
JBrowse link
G Dipk1a divergent protein kinase domain 1A affects response to substance ISO DIPK1A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:108,055,908...108,134,943
Ensembl chr 5:108,055,919...108,134,951
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects response to substance ISO DKK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 affects response to substance ISO DKK3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264
JBrowse link
G Donson downstream neighbor of SON affects response to substance ISO DONSON protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:91,463,744...91,485,702
Ensembl chr16:91,473,696...91,485,658
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 affects response to substance ISO DSCC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:54,939,497...54,953,887
Ensembl chr15:54,939,495...54,953,887
JBrowse link
G E2f1 E2F transcription factor 1 increases response to substance ISO E2F1 protein results in increased susceptibility to Vinblastine CTD PMID:16849574 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Vinblastine results in increased expression of EDNRB mRNA CTD PMID:20624997 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Efcab7 EF-hand calcium binding domain 7 affects response to substance ISO EFCAB7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:99,717,440...99,769,985
Ensembl chr 4:99,717,435...99,769,985
JBrowse link
G Emp2 epithelial membrane protein 2 affects response to substance ISO EMP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:10,099,613...10,131,832
Ensembl chr16:10,099,613...10,131,832
JBrowse link
G Epcam epithelial cell adhesion molecule affects response to substance ISO EPCAM protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 increases expression ISO Vinblastine results in increased expression of EPRS1 mRNA CTD PMID:20624997 NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance ISO ERBB2 protein affects the susceptibility to Vinblastine CTD PMID:10327070 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542
JBrowse link
G Ereg epiregulin affects response to substance ISO EREG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G Esm1 endothelial cell-specific molecule 1 decreases expression ISO Vinblastine results in decreased expression of ESM1 mRNA CTD PMID:20624997 NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632
JBrowse link
G Etfb electron transferring flavoprotein, beta polypeptide affects response to substance ISO ETFB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:43,093,496...43,107,224
Ensembl chr 7:43,093,507...43,107,224
JBrowse link
G Exosc9 exosome component 9 affects response to substance ISO EXOSC9 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:36,606,755...36,619,876
Ensembl chr 3:36,606,755...36,619,876
JBrowse link
G F3 coagulation factor III increases expression ISO Vinblastine results in increased expression of F3 mRNA CTD PMID:20624997 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C affects response to substance ISO FAM3C protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:22,306,519...22,356,080
Ensembl chr 6:22,306,519...22,356,242
JBrowse link
G Fancl Fanconi anemia, complementation group L affects response to substance ISO FANCL protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:26,337,084...26,421,883
Ensembl chr11:26,336,135...26,421,876
JBrowse link
G Fasl Fas ligand increases expression ISO Vinblastine results in increased expression of FASLG protein CTD PMID:11716366 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb increases expression ISO Vinblastine results in increased expression of FCGR2B mRNA CTD PMID:20624997 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116
JBrowse link
G Fen1 flap structure specific endonuclease 1 affects response to substance ISO FEN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533
JBrowse link
G Fkbp1a FK506 binding protein 1a affects response to substance ISO FKBP1A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612
JBrowse link
G Fli1 Friend leukemia integration 1 affects response to substance ISO FLI1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157
JBrowse link
G Fn1 fibronectin 1 affects response to substance ISO FN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fosl1 fos-like antigen 1 affects response to substance ISO FOSL1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
JBrowse link
G G0s2 G0/G1 switch gene 2 affects response to substance ISO G0S2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:192,954,468...192,955,496
Ensembl chr 1:192,954,469...192,955,525
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Vinblastine results in increased expression of GADD45A mRNA CTD PMID:20624997 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO Vinblastine results in increased expression of GADD45B mRNA CTD PMID:20624997 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO Vinblastine results in increased expression of GADD45G mRNA CTD PMID:20624997 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
JBrowse link
G Gas7 growth arrest specific 7 decreases expression ISO Vinblastine results in decreased expression of GAS7 mRNA CTD PMID:20624997 NCBI chr11:67,344,083...67,579,818
Ensembl chr11:67,345,917...67,575,800
JBrowse link
G Ggct gamma-glutamyl cyclotransferase affects response to substance ISO GGCT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:54,962,080...54,969,947
Ensembl chr 6:54,959,565...54,969,935
JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance ISO GGCX protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695
JBrowse link
G Gmnn geminin affects response to substance ISO GMNN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906
JBrowse link
G Gnptab N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits affects response to substance ISO GNPTAB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:88,215,130...88,283,186
Ensembl chr10:88,214,994...88,283,191
JBrowse link
G Gpr176 G protein-coupled receptor 176 affects response to substance ISO GPR176 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:118,107,577...118,205,022
Ensembl chr 2:118,107,591...118,203,900
JBrowse link
G Gpsm2 G-protein signalling modulator 2 (AGS3-like, C. elegans) affects response to substance ISO GPSM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:108,585,954...108,629,637
Ensembl chr 3:108,585,954...108,629,625
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases response to substance ISO GSTP1 protein results in decreased susceptibility to Vinblastine CTD PMID:11455017 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gtf2i general transcription factor II I affects response to substance ISO GTF2I protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:134,266,686...134,346,571
Ensembl chr 5:134,266,688...134,343,614
JBrowse link
G Gtf3a general transcription factor III A affects response to substance ISO GTF3A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:146,885,467...146,892,424
Ensembl chr 5:146,885,467...146,892,424
JBrowse link
G Gtse1 G two S phase expressed protein 1 affects response to substance ISO GTSE1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
JBrowse link
G Gusb glucuronidase, beta affects response to substance ISO GUSB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
JBrowse link
G H1f2 H1.2 linker histone, cluster member affects response to substance ISO H1-2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350
JBrowse link
G Hadh hydroxyacyl-Coenzyme A dehydrogenase affects response to substance ISO HADH protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 affects response to substance ISO HCLS1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:36,755,345...36,783,576
Ensembl chr16:36,755,345...36,783,574
JBrowse link
G Hmgb1 high mobility group box 1 affects response to substance ISO HMGB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmgb2 high mobility group box 2 affects response to substance ISO HMGB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
JBrowse link
G Hmgn3 high mobility group nucleosomal binding domain 3 affects response to substance ISO HMGN3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:82,991,995...83,029,411
Ensembl chr 9:82,992,001...83,028,738
JBrowse link
G Hmmr hyaluronan mediated motility receptor (RHAMM) affects response to substance ISO HMMR protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Vinblastine results in increased expression of HMOX1 mRNA CTD PMID:20624997 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Homer1 homer scaffolding protein 1 affects response to substance ISO HOMER1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
decreases expression
ISO Vinblastine results in increased expression of ICAM1 mRNA
Vinblastine results in decreased expression of ICAM1 mRNA; Vinblastine results in decreased expression of ICAM1 protein
CTD PMID:12649748 PMID:20624997 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Id2 inhibitor of DNA binding 2 affects response to substance ISO ID2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial affects response to substance ISO IDH2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of IKBKB protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188
JBrowse link
G Il1b interleukin 1 beta affects response to substance
increases expression
ISO IL1B protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of IL1B mRNA
CTD PMID:16217747 PMID:20624997 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Vinblastine results in decreased chemical synthesis of IL6 protein
Vinblastine results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inha inhibin alpha decreases expression ISO Vinblastine results in decreased expression of INHA mRNA CTD PMID:20624997 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010
JBrowse link
G Inhba inhibin beta-A affects response to substance ISO INHBA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Itgal integrin alpha L decreases expression ISO Vinblastine results in decreased expression of ITGAL mRNA; Vinblastine results in decreased expression of ITGAL protein CTD PMID:12649748 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
JBrowse link
G Itgb1bp1 integrin beta 1 binding protein 1 affects response to substance ISO ITGB1BP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:21,317,247...21,336,285
Ensembl chr12:21,290,826...21,336,285
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases phosphorylation
ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein] CTD PMID:12221076 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 affects response to substance ISO KANK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:25,214,146...25,411,861
Ensembl chr19:25,214,339...25,411,860
JBrowse link
G Kazn kazrin, periplakin interacting protein affects response to substance ISO KAZN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:141,829,701...142,801,231
Ensembl chr 4:141,829,701...142,205,056
JBrowse link
G Kif11 kinesin family member 11 affects response to substance ISO KIF11 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:37,364,830...37,410,311
Ensembl chr19:37,364,851...37,410,307
JBrowse link
G Kif15 kinesin family member 15 affects response to substance ISO KIF15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:122,780,146...122,847,798
Ensembl chr 9:122,780,111...122,847,798
JBrowse link
G Kif1b kinesin family member 1B affects response to substance ISO KIF1B protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150
JBrowse link
G Kif20a kinesin family member 20A affects response to substance ISO KIF20A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
JBrowse link
G Kif23 kinesin family member 23 affects response to substance ISO KIF23 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056
JBrowse link
G Kif4 kinesin family member 4 affects response to substance ISO KIF4A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:99,669,693...99,770,878
Ensembl chr  X:99,669,343...99,770,820
JBrowse link
G Kpna2 karyopherin subunit alpha 2 affects response to substance ISO KPNA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367
JBrowse link
G Lmnb1 lamin B1 affects response to substance ISO LMNB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 affects response to substance ISO LPAR1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898
JBrowse link
G Lrrc1 leucine rich repeat containing 1 affects response to substance ISO LRRC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:77,338,103...77,453,749
Ensembl chr 9:77,338,105...77,452,152
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated affects response to substance ISO LSM7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:80,688,659...80,691,043
Ensembl chr10:80,688,655...80,691,043
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 affects response to substance ISO LTBP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:84,829,986...84,923,581
Ensembl chr12:84,829,986...84,923,306
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 affects response to substance ISO MAD2L1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of MAPK8 protein
TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]
CTD PMID:12221076 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapkapk5 MAP kinase-activated protein kinase 5 affects response to substance ISO MAPKAPK5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:121,663,114...121,683,955
Ensembl chr 5:121,663,101...121,683,968
JBrowse link
G Melk maternal embryonic leucine zipper kinase affects response to substance ISO MELK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:44,300,876...44,364,301
Ensembl chr 4:44,300,876...44,364,675
JBrowse link
G Mme membrane metallo endopeptidase affects response to substance ISO MME protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) affects response to substance ISO MMP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mok MOK protein kinase affects response to substance ISO MOK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:110,770,404...110,807,391
Ensembl chr12:110,774,232...110,807,373
JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 affects response to substance ISO MRPL57 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:58,063,662...58,066,544
Ensembl chr14:58,063,691...58,066,753
JBrowse link
G Myc myelocytomatosis oncogene affects response to substance
increases expression
ISO MYC protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of MYC mRNA
CTD PMID:18802399 PMID:20624997 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Mycbp MYC binding protein affects response to substance ISO MYCBP protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:123,798,806...123,806,043
Ensembl chr 4:123,798,625...123,806,062
JBrowse link
G Nbn nibrin increases expression ISO Vinblastine results in increased expression of NBN mRNA CTD PMID:20624997 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G affects response to substance ISO NCAPG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:45,827,212...45,858,491
Ensembl chr 5:45,827,261...45,857,888
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H affects response to substance ISO NCAPH protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
JBrowse link
G Ndc80 NDC80 kinetochore complex component affects response to substance ISO NDC80 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects response to substance ISO NDUFA1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:36,451,241...36,454,891
Ensembl chr  X:36,451,241...36,454,816
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects response to substance ISO NDUFA13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:70,346,813...70,355,208
Ensembl chr 8:70,346,830...70,355,208
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 affects response to substance ISO NDUFA3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:3,620,372...3,623,162
Ensembl chr 7:3,620,372...3,623,326
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 affects response to substance ISO NDUFA7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:34,043,546...34,057,290
Ensembl chr17:34,043,546...34,057,291
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects response to substance ISO NDUFB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:39,569,499...39,576,777
Ensembl chr 6:39,569,508...39,580,316
JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 affects response to substance ISO NDUFC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:51,312,876...51,323,167
Ensembl chr 3:51,312,098...51,316,409
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 affects response to substance ISO NDUFC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:97,049,210...97,057,007
Ensembl chr 7:97,049,210...97,057,009
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase core subunit S6 affects response to substance ISO NDUFS6 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:73,467,995...73,476,574
Ensembl chr13:73,467,957...73,476,661
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 affects response to substance ISO NDUFV2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 decreases localization ISO Vinblastine results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of NFKBIA protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Ngf nerve growth factor decreases response to substance ISO Vinblastine results in decreased susceptibility to NGF protein CTD PMID:9524088 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Npy neuropeptide Y decreases expression ISO Vinblastine results in decreased expression of NPY mRNA CTD PMID:1671012 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein] CTD PMID:20041327 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor affects response to substance ISO NSMAF protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:6,396,207...6,454,840
Ensembl chr 4:6,396,207...6,454,271
JBrowse link
G Nudt15 nudix hydrolase 15 affects response to substance ISO NUDT15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:73,756,320...73,785,682
Ensembl chr14:73,756,317...73,785,682
JBrowse link
G Nudt4 nudix hydrolase 4 affects response to substance ISO NUDT4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:95,382,869...95,400,008
Ensembl chr10:95,382,869...95,400,008
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 affects response to substance ISO NUSAP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:119,449,205...119,480,646
Ensembl chr 2:119,448,779...119,481,725
JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 affects response to substance ISO OAZ1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:80,662,490...80,665,124
Ensembl chr10:80,662,516...80,665,124
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions EXP Vinblastine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:9270009 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Oip5 Opa interacting protein 5 affects response to substance ISO OIP5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:119,440,013...119,448,986
Ensembl chr 2:119,439,993...119,448,950
JBrowse link
G Or1i2 olfactory receptor family 1 subfamily I member 1 affects response to substance ISO OR1I1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:78,447,503...78,453,908
Ensembl chr10:78,446,837...78,453,908
JBrowse link
G Orc6 origin recognition complex, subunit 6 affects response to substance ISO ORC6 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:86,026,261...86,034,908
Ensembl chr 8:86,026,261...86,034,907
JBrowse link
G Osbpl10 oxysterol binding protein-like 10 affects response to substance ISO OSBPL10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:114,807,531...115,062,341
Ensembl chr 9:114,807,637...115,061,293
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein] CTD PMID:16545138 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta affects response to substance ISO PDHB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor affects response to substance ISO PELO protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:115,224,891...115,226,694
Ensembl chr13:115,224,891...115,226,722
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 affects response to substance ISO PGRMC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:35,861,846...35,869,732
Ensembl chr  X:35,861,859...35,869,732
JBrowse link
G Pir pirin affects response to substance ISO PIR protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007
JBrowse link
G Plagl1 pleiomorphic adenoma gene-like 1 increases expression ISO Vinblastine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 NCBI chr10:12,966,576...13,007,438
Ensembl chr10:12,936,248...13,007,438
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Vinblastine results in increased expression of PLAT mRNA CTD PMID:20624997 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plau plasminogen activator, urokinase affects response to substance ISO PLAU protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Vinblastine results in increased expression of PLAUR mRNA CTD PMID:20624997 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Vinblastine results in increased expression of PPP1R15A mRNA CTD PMID:20624997 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
JBrowse link
G Prc1 protein regulator of cytokinesis 1 affects response to substance ISO PRC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Vinblastine affects the localization of PRKCD protein CTD PMID:9852137 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Psmb1 proteasome (prosome, macropain) subunit, beta type 1 affects response to substance ISO PSMB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:15,695,983...15,718,538
Ensembl chr17:15,695,283...15,720,013
JBrowse link
G Psme4 proteasome (prosome, macropain) activator subunit 4 affects response to substance ISO PSME4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:30,721,753...30,831,150
Ensembl chr11:30,721,726...30,830,361
JBrowse link
G Ptges3 prostaglandin E synthase 3 affects response to substance ISO PTGES3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141
JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 affects response to substance ISO PTTG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078
JBrowse link
G Ptx3 pentraxin related gene affects response to substance ISO PTX3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226
JBrowse link
G Qrich1 glutamine-rich 1 increases phosphorylation ISO Vinblastine results in increased phosphorylation of QRICH1 protein CTD PMID:17510977 NCBI chr 9:108,394,010...108,437,366
Ensembl chr 9:108,394,005...108,437,362
JBrowse link
G Rab11fip1 RAB11 family interacting protein 1 (class I) affects response to substance ISO RAB11FIP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:27,628,801...27,664,707
Ensembl chr 8:27,628,801...27,664,674
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 affects response to substance ISO RACGAP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:99,518,377...99,549,504
Ensembl chr15:99,518,377...99,549,537
JBrowse link
G Ranbp1 RAN binding protein 1 affects response to substance ISO RANBP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:18,057,843...18,066,558
Ensembl chr16:18,057,648...18,066,596
JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 increases expression ISO Vinblastine results in increased expression of RASSF1 mRNA CTD PMID:20624997 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit affects response to substance ISO REV3L protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:39,607,557...39,751,207
Ensembl chr10:39,608,114...39,751,207
JBrowse link
G Rfc5 replication factor C (activator 1) 5 affects response to substance ISO RFC5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:117,517,210...117,527,088
Ensembl chr 5:117,516,168...117,527,112
JBrowse link
G Rpa3 replication protein A3 affects response to substance ISO RPA3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
JBrowse link
G Rrm2 ribonucleotide reductase M2 affects response to substance ISO RRM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Vinblastine results in increased expression of S100A8 mRNA CTD PMID:20624997 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Vinblastine results in increased expression of S100A9 mRNA CTD PMID:20624997 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Sele selectin, endothelial cell increases expression ISO Vinblastine results in increased expression of SELE mRNA CTD PMID:20624997 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 affects response to substance ISO SERPINB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression
affects response to substance
ISO Vinblastine results in increased expression of SERPINE1 mRNA
SERPINE1 protein affects the susceptibility to Vinblastine
CTD PMID:16217747 PMID:20624997 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sfxn1 sideroflexin 1 affects response to substance ISO SFXN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
JBrowse link
G Shtn1 shootin 1 affects response to substance ISO SHTN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:58,961,790...59,064,536
Ensembl chr19:58,961,788...59,064,532
JBrowse link
G Skic8 SKI8 subunit of superkiller complex affects response to substance ISO SKIC8 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:54,624,437...54,641,833
Ensembl chr 9:54,622,019...54,641,803
JBrowse link
G Skp2 S-phase kinase-associated protein 2 affects response to substance ISO SKP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 affects response to substance ISO SLC22A3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
JBrowse link
G Snrnp25 small nuclear ribonucleoprotein 25 (U11/U12) affects response to substance ISO SNRNP25 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:32,155,415...32,158,996
Ensembl chr11:32,155,415...32,158,984
JBrowse link
G Snx10 sorting nexin 10 affects response to substance ISO SNX10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:51,500,882...51,567,659
Ensembl chr 6:51,500,881...51,567,659
JBrowse link
G Sod1 superoxide dismutase 1, soluble affects response to substance ISO SOD1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA] CTD PMID:9852137 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sort1 sortilin 1 affects response to substance ISO SORT1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:108,191,272...108,268,835
Ensembl chr 3:108,191,398...108,268,827
JBrowse link
G Spon1 spondin 1, (f-spondin) extracellular matrix protein increases expression ISO Vinblastine results in increased expression of SPON1 mRNA CTD PMID:20624997 NCBI chr 7:113,365,235...113,642,610
Ensembl chr 7:113,365,235...113,642,605
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects response to substance ISO SRD5A1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561
JBrowse link
G Srgn serglycin affects response to substance ISO SRGN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Vinblastine deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Vinblastine deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stc2 stanniocalcin 2 affects response to substance ISO STC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074
JBrowse link
G Stk26 serine/threonine kinase 26 affects response to substance ISO STK26 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:49,930,052...49,981,980
Ensembl chr  X:49,929,924...49,981,974
JBrowse link
G Strn striatin, calmodulin binding protein affects response to substance ISO STRN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:78,957,327...79,043,990
Ensembl chr17:78,957,342...79,044,625
JBrowse link
G Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit affects response to substance ISO SUCLA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:73,790,226...73,833,584
Ensembl chr14:73,762,759...73,833,582
JBrowse link
G Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit affects response to substance ISO SUCLG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894
JBrowse link
G Syde1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) affects response to substance ISO SYDE1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:78,420,336...78,427,798
Ensembl chr10:78,420,337...78,427,798
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 affects response to substance ISO TBC1D4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:101,679,800...101,846,717
Ensembl chr14:101,679,796...101,846,627
JBrowse link
G Tdg thymine DNA glycosylase affects response to substance ISO TDG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:82,465,649...82,486,633
Ensembl chr10:82,465,662...82,486,633
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 affects response to substance
increases expression
ISO TFPI2 protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of TFPI2 mRNA
CTD PMID:16217747 PMID:20624997 NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919
JBrowse link
G Thbd thrombomodulin increases expression ISO Vinblastine results in increased expression of THBD mRNA CTD PMID:20624997 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Vinblastine results in increased expression of THBS1 mRNA CTD PMID:20624997 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Vinblastine results in increased expression of TIMP1 mRNA CTD PMID:20624997 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tmem134 transmembrane protein 134 affects response to substance ISO TMEM134 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:4,175,960...4,182,306
Ensembl chr19:4,175,934...4,182,306
JBrowse link
G Tmem14a transmembrane protein 14A affects response to substance ISO TMEM14A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:21,236,609...21,300,391
Ensembl chr 1:21,288,799...21,300,391
JBrowse link
G Tmem156 transmembrane protein 156 affects response to substance ISO TMEM156 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:65,215,558...65,249,524
Ensembl chr 5:65,211,689...65,249,475
JBrowse link
G Tmem97 transmembrane protein 97 affects response to substance ISO TMEM97 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:78,432,643...78,441,561
Ensembl chr11:78,432,643...78,441,603
JBrowse link
G Tmpo thymopoietin affects response to substance ISO TMPO protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:90,983,433...91,017,614
Ensembl chr10:90,983,433...91,017,177
JBrowse link
G Top2a topoisomerase (DNA) II alpha affects response to substance ISO TOP2A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
JBrowse link
G Tpd52l1 tumor protein D52-like 1 increases expression
affects response to substance
ISO Vinblastine results in increased expression of TPD52L1 mRNA
TPD52L1 protein affects the susceptibility to Vinblastine
CTD PMID:16217747 PMID:20624997 NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954
JBrowse link
G Traj18 T cell receptor alpha joining 18 increases expression EXP Vinblastine results in increased expression of STK17A mRNA CTD PMID:21489989 NCBI chr14:54,438,234...54,438,299
Ensembl chr14:54,438,234...54,438,299
JBrowse link
G Trim2 tripartite motif-containing 2 affects response to substance ISO TRIM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184
JBrowse link
G Trmt5 TRM5 tRNA methyltransferase 5 affects response to substance ISO TRMT5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:73,315,289...73,333,754
Ensembl chr12:73,326,785...73,333,484
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tspan13 tetraspanin 13 affects response to substance ISO TSPAN13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:36,064,554...36,092,477
Ensembl chr12:36,064,556...36,092,499
JBrowse link
G Ttf2 transcription termination factor, RNA polymerase II affects response to substance ISO TTF2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:100,846,176...100,877,016
Ensembl chr 3:100,846,176...100,876,979
JBrowse link
G Ttk Ttk protein kinase affects response to substance ISO TTK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442
JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression ISO Vinblastine results in decreased expression of TUBA1B mRNA CTD PMID:20624997 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Vinblastine results in decreased expression of TUBA4A mRNA CTD PMID:20624997 NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509
JBrowse link
G Tubb4b tubulin, beta 4B class IVB decreases expression ISO Vinblastine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Vinblastine results in decreased expression of TUBB5 mRNA CTD PMID:20624997 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tubg1 tubulin, gamma 1 decreases expression ISO Vinblastine results in decreased expression of TUBG1 mRNA CTD PMID:20624997 NCBI chr11:101,010,725...101,017,249
Ensembl chr11:101,010,764...101,017,245
JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X affects response to substance ISO UQCR10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:4,651,968...4,654,344
Ensembl chr11:4,651,973...4,654,342
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Vinblastine results in increased expression of VCAM1 mRNA CTD PMID:20624997 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Vinblastine results in decreased expression of VEGFA mRNA CTD PMID:20624997 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vegfc vascular endothelial growth factor C affects response to substance ISO VEGFC protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131
JBrowse link
G Vwf Von Willebrand factor increases expression ISO Vinblastine results in increased expression of VWF mRNA CTD PMID:20624997 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642
JBrowse link
G Wsb2 WD repeat and SOCS box-containing 2 affects response to substance ISO WSB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:117,495,370...117,516,666
Ensembl chr 5:117,495,369...117,516,666
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta affects response to substance ISO YWHAQ protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638
JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 affects response to substance ISO ZFP36L2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375
JBrowse link
G Zwint ZW10 interactor affects response to substance ISO ZWINT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796
JBrowse link
vincamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Vincamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700017B05Rik RIKEN cDNA 1700017B05 gene decreases expression ISO Vincristine results in decreased expression of C15ORF39 mRNA CTD PMID:23649840 NCBI chr 9:57,159,605...57,169,882
Ensembl chr 9:57,160,400...57,169,895
JBrowse link
G 1700031M16Rik RIKEN cDNA 1700031M16 gene increases expression ISO Vincristine results in increased expression of C12ORF54 mRNA CTD PMID:23649840 NCBI chr15:98,296,326...98,314,016
Ensembl chr15:98,296,300...98,314,149
Ensembl chr15:98,296,300...98,314,149
JBrowse link
G 2310057J18Rik RIKEN cDNA 2310057J18 gene increases expression ISO Vincristine results in increased expression of C6ORF58 mRNA CTD PMID:23649840 NCBI chr10:28,848,284...28,862,302
Ensembl chr10:28,848,284...28,862,299
JBrowse link
G A130010J15Rik RIKEN cDNA A130010J15 gene decreases expression ISO Vincristine results in decreased expression of C1ORF74 mRNA CTD PMID:23649840 NCBI chr 1:192,855,777...192,860,145
Ensembl chr 1:192,850,354...192,860,140
JBrowse link
G Aamdc adipogenesis associated Mth938 domain containing increases expression ISO Vincristine results in increased expression of AAMDC mRNA CTD PMID:23649840 NCBI chr 7:97,199,538...97,228,723
Ensembl chr 7:97,199,538...97,228,704
JBrowse link
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA1 mRNA CTD PMID:19944135 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abca12 ATP-binding cassette, sub-family A member 12 increases expression
multiple interactions
ISO Vincristine results in increased expression of ABCA12 mRNA
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA12 mRNA
CTD PMID:19944135 PMID:23649840 NCBI chr 1:71,282,249...71,454,069
Ensembl chr 1:71,281,435...71,454,069
JBrowse link
G Abca4 ATP-binding cassette, sub-family A member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA4 mRNA CTD PMID:19944135 NCBI chr 3:121,837,547...121,973,719
Ensembl chr 3:121,838,092...121,973,772
JBrowse link
G Abca5 ATP-binding cassette, sub-family A member 5 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA5 mRNA CTD PMID:19944135 NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542
JBrowse link
G Abca8b ATP-binding cassette, sub-family A member 8b multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA8 mRNA CTD PMID:19944135 NCBI chr11:109,823,016...109,886,642
Ensembl chr11:109,823,016...109,886,671
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance
increases expression
multiple interactions
increases transport
decreases uptake
decreases response to substance
affects uptake
ISO ABCB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of ABCB1A mRNA
Vincristine results in increased expression of ABCB1 protein
[Estradiol results in decreased expression of ABCB1 protein] which results in increased uptake of and results in increased susceptibility to Vincristine; [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB1 mRNA; [Vincristine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Fenofibrate inhibits the reaction [ABCB1 protein results in increased transport of Vincristine]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; NR1I2 protein promotes the reaction [Vincristine results in increased expression of ABCB1 protein]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; zosuquidar trihydrochloride inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased uptake of Vincristine
ABCB1 protein affects the uptake of Vincristine
CTD PMID:7905786 PMID:10617675 PMID:11792417 PMID:11934808 PMID:15239124 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects uptake ISO ABCB1B protein affects the uptake of Vincristine CTD PMID:11934808 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB4 mRNA CTD PMID:19944135 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcb6 ATP-binding cassette, sub-family B member 6 multiple interactions
decreases response to substance
ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB6 mRNA
ABCB6 protein results in decreased susceptibility to Vincristine
CTD PMID:19944135 PMID:25202056 NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 increases response to substance
increases expression
multiple interactions
decreases response to substance
affects transport
affects response to substance
affects export
ISO
EXP
ABCC1 gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of ABCC1 mRNA
[Genistein results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
ABCC1 protein results in decreased susceptibility to Vincristine; ABCC1 results in decreased susceptibility to Vincristine
[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC1 mRNA; ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Doxorubicin inhibits the reaction [ABCC1 protein affects the transport of Vincristine]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Quercetin promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; zafirlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]
ABCC1 protein affects the transport of Vincristine; ABCC1 protein mutant form affects the transport of Vincristine
ABCC1 protein affects the susceptibility to Vincristine
CTD PMID:7954421 PMID:8649356 PMID:8968083 PMID:10348353 PMID:10685512 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc10 ATP-binding cassette, sub-family C member 10 multiple interactions
decreases response to substance
ISO Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine] CTD PMID:19841739 NCBI chr17:46,614,146...46,638,954
Ensembl chr17:46,614,147...46,639,278
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects export
multiple interactions
decreases response to substance
ISO ABCC2 protein affects the export of Vincristine
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC2 mRNA; ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine; myricetin inhibits the reaction [ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC2 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC2 protein results in decreased susceptibility to Vincristine]
CTD PMID:15896345 PMID:19944135 PMID:22095822 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC3 mRNA CTD PMID:19944135 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC4 mRNA CTD PMID:19944135 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C member 5 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCC5 mRNA CTD PMID:19944135 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC6 mRNA CTD PMID:19944135 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
G Abcd3 ATP-binding cassette, sub-family D member 3 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCD3 mRNA CTD PMID:19944135 NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG1 mRNA CTD PMID:19944135 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCG2 mRNA CTD PMID:19944135 PMID:21833476 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG4 mRNA CTD PMID:19944135 NCBI chr 9:44,184,485...44,199,953
Ensembl chr 9:44,184,485...44,199,912
JBrowse link
G Abhd11 abhydrolase domain containing 11 decreases expression ISO Vincristine results in decreased expression of ABHD11 mRNA CTD PMID:23649840 NCBI chr 5:135,038,006...135,041,029
Ensembl chr 5:135,038,006...135,041,029
JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 increases expression ISO Vincristine results in increased expression of ABTB2 mRNA CTD PMID:23649840 NCBI chr 2:103,396,655...103,548,768
Ensembl chr 2:103,396,655...103,548,768
JBrowse link
G Acad9 acyl-Coenzyme A dehydrogenase family, member 9 decreases expression ISO Vincristine results in decreased expression of ACAD9 mRNA CTD PMID:23649840 NCBI chr 3:36,120,128...36,147,006
Ensembl chr 3:36,120,128...36,147,002
JBrowse link
G Ache acetylcholinesterase decreases expression
multiple interactions
ISO Vincristine results in decreased expression of ACHE protein
xaliproden inhibits the reaction [Vincristine results in decreased expression of ACHE protein]
CTD PMID:8413926 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Vincristine results in increased expression of ACKR3 mRNA CTD PMID:23649840 NCBI chr 1:90,131,702...90,143,446
Ensembl chr 1:90,131,702...90,144,473
JBrowse link
G Actr2 actin related protein 2 increases expression ISO Vincristine results in increased expression of ACTR2 mRNA CTD PMID:23649840 NCBI chr11:20,012,304...20,062,951
Ensembl chr11:20,012,304...20,062,913
JBrowse link
G Adat2 adenosine deaminase, tRNA-specific 2 decreases expression ISO Vincristine results in decreased expression of ADAT2 mRNA CTD PMID:23649840 NCBI chr10:13,428,651...13,439,120
Ensembl chr10:13,428,638...13,439,120
JBrowse link
G Adgrf4 adhesion G protein-coupled receptor F4 increases expression ISO Vincristine results in increased expression of ADGRF4 mRNA CTD PMID:23649840 NCBI chr17:42,967,099...43,008,460
Ensembl chr17:42,967,782...43,003,175
JBrowse link
G Adrb1 adrenergic receptor, beta 1 decreases expression ISO Vincristine results in decreased expression of ADRB1 mRNA CTD PMID:23649840 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545
JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases response to substance ISO ADRB2 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030
JBrowse link
G Agbl3 ATP/GTP binding protein-like 3 decreases expression ISO Vincristine results in decreased expression of AGBL3 mRNA CTD PMID:23649840 NCBI chr 6:34,755,249...34,837,874
Ensembl chr 6:34,757,367...34,836,394
JBrowse link
G Ahsa2 AHA1, activator of heat shock protein ATPase 2 decreases expression ISO Vincristine results in decreased expression of AHSA2P mRNA CTD PMID:23649840 NCBI chr11:23,437,882...23,448,045
Ensembl chr11:23,437,882...23,448,030
JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Vincristine results in increased expression of AIM2 mRNA CTD PMID:23649840 NCBI chr 1:173,177,105...173,293,606
Ensembl chr 1:173,178,445...173,293,606
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Vincristine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070
JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Vincristine results in decreased expression of AK3 mRNA CTD PMID:23649840 NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361
JBrowse link
G Akap10 A kinase anchor protein 10 increases expression ISO Vincristine results in increased expression of AKAP10 mRNA CTD PMID:23649840 NCBI chr11:61,756,029...61,821,134
Ensembl chr11:61,762,133...61,821,078
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression
EXP
ISO
Vincristine inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]
Quercetin inhibits the reaction [Vincristine results in decreased expression of AKT1 mRNA]
Vincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]
CTD PMID:16740780 PMID:18590705 PMID:33038355 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [Vincristine results in decreased expression of AKT2 mRNA] CTD PMID:33038355 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G Aldoc aldolase C, fructose-bisphosphate decreases expression ISO Vincristine results in decreased expression of ALDOC mRNA CTD PMID:23649840 NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated decreases expression ISO Vincristine results in decreased expression of ALMS1 mRNA CTD PMID:23649840 NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735
JBrowse link
G Alpk2 alpha-kinase 2 increases expression ISO Vincristine results in increased expression of ALPK2 mRNA CTD PMID:23649840 NCBI chr18:65,398,600...65,526,959
Ensembl chr18:65,398,600...65,527,137
JBrowse link
G Amh anti-Mullerian hormone decreases secretion EXP Vincristine results in decreased secretion of AMH protein CTD PMID:30657998 NCBI chr10:80,641,074...80,643,513
Ensembl chr10:80,641,077...80,643,482
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 increases expression ISO Vincristine results in increased expression of ANAPC5 mRNA CTD PMID:23649840 NCBI chr 5:122,925,522...122,960,402
Ensembl chr 5:122,925,522...122,959,402
JBrowse link
G Ankdd1a ankyrin repeat and death domain containing 1A decreases expression ISO Vincristine results in decreased expression of ANKDD1A mRNA CTD PMID:23649840 NCBI chr 9:65,395,746...65,427,691
Ensembl chr 9:65,395,752...65,427,475
JBrowse link
G Ankhd1 ankyrin repeat and KH domain containing 1 increases expression ISO Vincristine results in increased expression of ANKHD1 mRNA CTD PMID:23649840 NCBI chr18:36,693,656...36,791,961
Ensembl chr18:36,693,040...36,791,966
JBrowse link
G Ankra2 ankyrin repeat family A member 2 increases expression ISO Vincristine results in increased expression of ANKRA2 mRNA CTD PMID:23649840 NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262
JBrowse link
G Ankrd13c ankyrin repeat domain 13c decreases expression ISO Vincristine results in decreased expression of ANKRD13C mRNA CTD PMID:23649840 NCBI chr 3:157,650,886...157,713,671
Ensembl chr 3:157,652,876...157,713,671
JBrowse link
G Ankrd33b ankyrin repeat domain 33B increases expression ISO Vincristine results in increased expression of ANKRD33B mRNA CTD PMID:23649840 NCBI chr15:31,278,328...31,370,446
Ensembl chr15:31,291,624...31,367,872
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Vincristine results in decreased expression of ANKRD37 mRNA CTD PMID:23649840 NCBI chr 8:46,449,945...46,452,904
Ensembl chr 8:46,449,939...46,458,744
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E decreases expression ISO Vincristine results in decreased expression of ANP32E mRNA CTD PMID:23649840 NCBI chr 3:95,836,557...95,854,699
Ensembl chr 3:95,836,558...95,854,702
JBrowse link
G Anxa1 annexin A1 increases expression ISO Vincristine results in increased expression of ANXA1 mRNA CTD PMID:23649840 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Anxa2 annexin A2 increases expression ISO Vincristine results in increased expression of ANXA2 mRNA CTD PMID:23649840 NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077
JBrowse link
G Ap1s2 adaptor-related protein complex 1, sigma 2 subunit decreases expression ISO Vincristine results in decreased expression of AP1S2 mRNA CTD PMID:23649840 NCBI chr  X:162,691,427...162,716,662
Ensembl chr  X:162,692,013...162,716,662
JBrowse link
G Apex2 apurinic/apyrimidinic endonuclease 2 decreases expression ISO Vincristine results in decreased expression of APEX2 mRNA CTD PMID:23649840 NCBI chr  X:149,286,625...149,371,175
Ensembl chr  X:149,302,515...149,372,864
JBrowse link
G Apln apelin decreases expression ISO Vincristine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730
JBrowse link
G Apod apolipoprotein D increases expression ISO Vincristine results in increased expression of APOD mRNA CTD PMID:23649840 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626
JBrowse link
G Apold1 apolipoprotein L domain containing 1 increases expression ISO Vincristine results in increased expression of APOLD1 mRNA CTD PMID:23649840 NCBI chr 6:134,958,964...134,963,799
Ensembl chr 6:134,958,681...134,963,799
JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Vincristine results in increased expression of AQP9 mRNA CTD PMID:23649840 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 decreases expression ISO Vincristine results in decreased expression of ARAP2 mRNA CTD PMID:23649840 NCBI chr 5:62,759,788...62,923,874
Ensembl chr 5:62,759,788...62,923,502
JBrowse link
G Arf1 ADP-ribosylation factor 1 increases expression ISO Vincristine results in increased expression of ARF1 mRNA CTD PMID:23649840 NCBI chr11:59,102,237...59,119,042
Ensembl chr11:59,102,238...59,119,096
JBrowse link
G Arhgap15 Rho GTPase activating protein 15 increases expression ISO Vincristine results in increased expression of ARHGAP15 mRNA CTD PMID:23649840 NCBI chr 2:43,638,786...44,285,965
Ensembl chr 2:43,638,836...44,285,965
JBrowse link
G Arhgap18 Rho GTPase activating protein 18 decreases expression ISO Vincristine results in decreased expression of ARHGAP18 mRNA CTD PMID:23649840 NCBI chr10:26,648,363...26,794,644
Ensembl chr10:26,629,417...26,794,644
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression ISO Vincristine results in decreased expression of ARHGAP5 mRNA CTD PMID:23649840 NCBI chr12:52,550,555...52,618,761
Ensembl chr12:52,550,755...52,618,758
JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 increases expression ISO Vincristine results in increased expression of ARHGEF6 mRNA CTD PMID:23649840 NCBI chr  X:56,276,845...56,384,119
Ensembl chr  X:56,276,845...56,384,089
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor increases expression ISO Vincristine results in increased expression of ARHGEF7 mRNA CTD PMID:23649840 NCBI chr 8:11,778,053...11,885,219
Ensembl chr 8:11,777,721...11,885,219
JBrowse link
G Arid2 AT-rich interaction domain 2 increases expression ISO Vincristine results in increased expression of ARID2 mRNA CTD PMID:23649840 NCBI chr15:96,185,403...96,303,344
Ensembl chr15:96,185,399...96,302,873
JBrowse link
G Arid4b AT-rich interaction domain 4B increases expression ISO Vincristine results in increased expression of ARID4B mRNA CTD PMID:23649840 NCBI chr13:14,238,334...14,374,188
Ensembl chr13:14,237,817...14,374,188
JBrowse link
G Arl5a ADP-ribosylation factor-like 5A decreases expression ISO Vincristine results in decreased expression of ARL5A mRNA CTD PMID:23649840 NCBI chr 2:52,287,961...52,314,886
Ensembl chr 2:52,287,963...52,314,913
JBrowse link
G Arl5b ADP-ribosylation factor-like 5B increases expression ISO Vincristine results in increased expression of ARL5B mRNA CTD PMID:23649840 NCBI chr 2:15,060,066...15,087,267
Ensembl chr 2:15,054,206...15,087,267
JBrowse link
G Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 decreases expression ISO Vincristine results in decreased expression of ARL6IP1 mRNA CTD PMID:23649840 NCBI chr 7:117,718,113...117,728,848
Ensembl chr 7:117,718,114...117,728,885
JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO Vincristine results in decreased expression of ARMC8 mRNA CTD PMID:23649840 NCBI chr 9:99,360,438...99,451,471
Ensembl chr 9:99,360,425...99,450,952
JBrowse link
G Aspm abnormal spindle microtubule assembly increases expression ISO Vincristine results in increased expression of ASPM mRNA CTD PMID:17374387 NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 increases expression ISO Vincristine results in increased expression of ASXL1 mRNA CTD PMID:23649840 NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 decreases expression ISO Vincristine results in decreased expression of ATAD2 mRNA CTD PMID:23649840 NCBI chr15:57,957,440...57,998,516
Ensembl chr15:57,957,440...57,998,478
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Vincristine results in increased expression of ATF3 mRNA CTD PMID:23649840 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Vincristine results in increased expression of ATF5 mRNA CTD PMID:23649840 NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO Vincristine results in increased expression of ATF6 mRNA
Quercetin inhibits the reaction [Vincristine results in increased expression of ATF6 mRNA]
CTD PMID:33038355 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 increases expression ISO Vincristine results in increased expression of ATP2B4 mRNA CTD PMID:23649840 NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma decreases expression ISO Vincristine results in decreased expression of ATP5F1C mRNA CTD PMID:23649840 NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
JBrowse link
G Atp6v0e ATPase, H+ transporting, lysosomal V0 subunit E increases expression ISO Vincristine results in increased expression of ATP6V0E1 mRNA CTD PMID:23649840 NCBI chr17:26,895,370...26,918,621
Ensembl chr17:26,882,205...26,918,621
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide decreases response to substance ISO ATP7A protein results in decreased susceptibility to Vincristine CTD PMID:17510416 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 decreases expression ISO Vincristine results in decreased expression of ATP8A1 mRNA CTD PMID:23649840 NCBI chr 5:67,775,482...68,004,822
Ensembl chr 5:67,775,483...68,004,777
JBrowse link
G Aurka aurora kinase A increases response to substance
increases expression
ISO AURKA gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of AURKA mRNA
CTD PMID:17374387 PMID:20864405 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Vincristine results in decreased expression of AURKB mRNA CTD PMID:23649840 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
JBrowse link
G Avp arginine vasopressin increases expression ISO Vincristine results in increased expression of AVP protein CTD PMID:4356234 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
JBrowse link
G B3galt6 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 decreases expression ISO Vincristine results in decreased expression of B3GALT6 mRNA CTD PMID:23649840 NCBI chr 4:156,073,923...156,077,135
Ensembl chr 4:156,073,923...156,077,106
JBrowse link
G B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 increases expression ISO Vincristine results in increased expression of B3GNT5 mRNA CTD PMID:23649840 NCBI chr16:19,578,943...19,591,508
Ensembl chr16:19,578,958...19,591,503
JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects response to substance ISO BAK1 protein affects the susceptibility to Vincristine CTD PMID:22178383 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Vincristine results in increased expression of BAMBI mRNA CTD PMID:23649840 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO Vincristine results in decreased expression of BARD1 mRNA CTD PMID:23649840 NCBI chr 1:71,066,694...71,142,300
Ensembl chr 1:71,066,657...71,142,305
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Vincristine results in increased expression of BASP1 mRNA CTD PMID:23649840 NCBI chr15:25,363,363...25,413,850
Ensembl chr15:25,363,363...25,413,850
JBrowse link
G Batf basic leucine zipper transcription factor, ATF-like increases expression ISO Vincristine results in increased expression of BATF mRNA CTD PMID:23649840 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861
JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
multiple interactions
affects response to substance
ISO
EXP
Vincristine results in decreased expression of BAX mRNA
Vincristine results in increased expression of BAX mRNA; Vincristine results in increased expression of BAX protein
KN 93 inhibits the reaction [Vincristine results in increased expression of BAX mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of BAX protein]
Quercetin inhibits the reaction [Vincristine results in increased expression of BAX mRNA]
BAX protein affects the susceptibility to Vincristine
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; Vincristine results in increased cleavage of and results in increased expression of BAX protein
CTD PMID:9815696 PMID:15131059 PMID:16001973 PMID:22178383 PMID:33038355 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcat1 branched chain aminotransferase 1, cytosolic increases expression ISO Vincristine results in increased expression of BCAT1 mRNA CTD PMID:23649840 NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases response to substance
multiple interactions
decreases expression
increases phosphorylation
ISO
EXP
BCL2 protein results in decreased susceptibility to Vincristine
KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]; KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 protein]
Vincristine results in decreased expression of BCL2 mRNA; Vincristine results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]
Vincristine results in increased phosphorylation of BCL2 protein
[Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [MIR497 results in decreased expression of BCL2 protein] which results in increased susceptibility to Vincristine; TYMP inhibits the reaction [Vincristine results in increased phosphorylation of BCL2 protein]
CTD PMID:9815696 PMID:15907805 PMID:20162574 PMID:21182165 PMID:21258880 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b increases expression ISO Vincristine results in increased expression of BCL2A1 mRNA CTD PMID:23649840 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
JBrowse link
G Bcl2l1 BCL2-like 1 increases expression
affects response to substance
ISO Vincristine results in increased expression of BCL2L1 mRNA
BCL2L1 protein affects the susceptibility to Vincristine
CTD PMID:22178383 PMID:23649840 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Vincristine results in decreased expression of BCLAF1 mRNA CTD PMID:23649840 NCBI chr10:20,187,897...20,218,390
Ensembl chr10:20,188,215...20,220,359
JBrowse link
G Bcor BCL6 interacting corepressor increases expression ISO Vincristine results in increased expression of BCOR mRNA CTD PMID:23649840 NCBI chr  X:11,902,976...12,026,769
Ensembl chr  X:11,902,979...12,026,594
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 multiple interactions ISO [HOE 140, desArg(10)- binds to and results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Vincristine CTD PMID:17989505 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions ISO [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Vincristine CTD PMID:17989505 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Vincristine results in increased expression of BIRC2 mRNA CTD PMID:23649840 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Vincristine results in increased expression of BIRC3 mRNA CTD PMID:23649840 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Blm Bloom syndrome, RecQ like helicase decreases expression ISO Vincristine results in decreased expression of BLM mRNA CTD PMID:23649840 NCBI chr 7:80,104,839...80,184,896
Ensembl chr 7:80,104,481...80,184,867
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO Vincristine results in increased expression of BMP2 mRNA CTD PMID:23649840 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 decreases expression
multiple interactions
ISO Vincristine results in decreased expression of BNIP3 mRNA
Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]
CTD PMID:23649840 PMID:25446377 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like decreases expression ISO Vincristine results in decreased expression of BNIP3L mRNA CTD PMID:23649840 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression ISO Vincristine results in increased expression of BORCS7 mRNA CTD PMID:23649840 NCBI chr19:46,678,345...46,691,821
Ensembl chr19:46,678,345...46,691,821
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 decreases expression ISO Vincristine results in decreased expression of BRIP1 mRNA CTD PMID:23649840 NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019
JBrowse link
G Brwd1 bromodomain and WD repeat domain containing 1 decreases expression ISO Vincristine results in decreased expression of BRWD1 mRNA CTD PMID:23649840 NCBI chr16:95,793,289...95,883,905
Ensembl chr16:95,793,292...95,883,726
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Vincristine results in increased expression of BTG1 mRNA CTD PMID:23649840 NCBI chr10:96,452,863...96,458,675
Ensembl chr10:96,452,868...96,458,671
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Vincristine results in increased expression of BTG2 mRNA CTD PMID:23649840 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
JBrowse link
G Btg4 BTG anti-proliferation factor 4 increases expression ISO Vincristine results in increased expression of BTG4 mRNA CTD PMID:23649840 NCBI chr 9:51,013,486...51,031,224
Ensembl chr 9:50,972,201...51,031,175
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein decreases expression ISO Vincristine results in decreased expression of BUB3 mRNA CTD PMID:23649840 NCBI chr 7:131,162,081...131,173,625
Ensembl chr 7:131,161,951...131,173,624
JBrowse link
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 decreases expression ISO Vincristine results in decreased expression of C1GALT1 mRNA CTD PMID:23649840 NCBI chr 6:7,845,224...7,872,042
Ensembl chr 6:7,844,842...7,875,687
JBrowse link
G Cables2 CDK5 and Abl enzyme substrate 2 decreases expression ISO Vincristine results in decreased expression of CABLES2 mRNA CTD PMID:23649840 NCBI chr 2:179,900,332...179,915,258
Ensembl chr 2:179,900,333...179,915,289
JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit multiple interactions
increases expression
EXP Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of CACNA1H mRNA]; Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; KN 62 inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; zinc chloride inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]
Vincristine results in increased expression of CACNA1H mRNA; Vincristine results in increased expression of CACNA1H protein
CTD PMID:34286406 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759
JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit increases expression ISO Vincristine results in increased expression of CACNB2 mRNA CTD PMID:23649840 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719
JBrowse link
G Cald1 caldesmon 1 increases expression ISO Vincristine results in increased expression of CALD1 mRNA CTD PMID:23649840 NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Vincristine results in decreased expression of CALM2 mRNA CTD PMID:23649840 NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363
JBrowse link
G Calu calumenin increases expression ISO Vincristine results in increased expression of CALU mRNA CTD PMID:23649840 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta decreases expression ISO Vincristine results in decreased expression of CAMK2D mRNA CTD PMID:23649840 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha increases response to substance ISO CAMKK1 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr11:72,906,869...72,932,899
Ensembl chr11:72,909,834...72,932,899
JBrowse link
G Capg capping actin protein, gelsolin like increases expression ISO Vincristine results in increased expression of CAPG mRNA CTD PMID:23649840 NCBI chr 6:72,515,265...72,539,966
Ensembl chr 6:72,521,374...72,539,966
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression ISO Vincristine results in decreased expression of CARHSP1 mRNA CTD PMID:23649840 NCBI chr16:8,476,444...8,490,017
Ensembl chr16:8,476,444...8,490,019
JBrowse link
G Casp1 caspase 1 increases expression ISO Vincristine results in increased expression of CASP1 mRNA CTD PMID:23649840 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO
EXP
Vincristine results in increased cleavage of CASP3 protein
KN 93 inhibits the reaction [Vincristine results in increased cleavage of CASP3 protein]
Vincristine results in increased expression of CASP3 mRNA; Vincristine results in increased expression of CASP3 protein
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]; Quercetin inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Vincristine results in increased expression of CASP3 protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
CTD PMID:20624997 PMID:29958920 PMID:33038355 PMID:34286406 PMID:34939713 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp6 caspase 6 increases expression ISO Vincristine results in increased expression of CASP6 mRNA CTD PMID:16001973 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Casp8 caspase 8 increases expression
increases response to substance
multiple interactions
ISO Vincristine results in increased expression of CASP8 mRNA
CASP8 protein results in increased susceptibility to Vincristine
Vincristine results in increased expression of and results in increased cleavage of CASP8 protein
CTD PMID:16001973 PMID:22010212 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Cat catalase affects response to substance
decreases activity
decreases expression
multiple interactions
ISO CAT protein affects the susceptibility to Vincristine
Vincristine results in decreased activity of CAT protein
Vincristine results in decreased expression of CAT protein
Quercetin inhibits the reaction [Vincristine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
CTD PMID:11178967 PMID:24201307 PMID:25537132 PMID:26102012 PMID:36808657 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO Vincristine results in decreased expression of CBX3 mRNA CTD PMID:23649840 NCBI chr 6:51,447,596...51,460,684
Ensembl chr 6:51,447,340...51,460,684
JBrowse link
G Cbx5 chromobox 5 decreases expression ISO Vincristine results in decreased expression of CBX5 mRNA CTD PMID:23649840 NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 decreases expression ISO Vincristine results in decreased expression of CCAR1 mRNA CTD PMID:23649840 NCBI chr10:62,579,707...62,628,147
Ensembl chr10:62,579,707...62,628,065
JBrowse link
G Ccdc12 coiled-coil domain containing 12 decreases expression ISO Vincristine results in decreased expression of CCDC12 mRNA CTD PMID:23649840 NCBI chr 9:110,483,376...110,540,661
Ensembl chr 9:110,485,571...110,540,674
JBrowse link
G Ccdc186 coiled-coil domain containing 186 decreases expression ISO Vincristine results in decreased expression of CCDC186 mRNA CTD PMID:23649840 NCBI chr19:56,775,917...56,810,631
Ensembl chr19:56,775,913...56,810,622
JBrowse link
G Ccdc198 coiled-coil domain containing 198 decreases expression ISO Vincristine results in decreased expression of CCDC198 mRNA CTD PMID:23649840 NCBI chr14:49,463,815...49,482,902
Ensembl chr14:49,457,045...49,482,931
JBrowse link
G Ccdc32 coiled-coil domain containing 32 decreases expression ISO Vincristine results in decreased expression of CCDC32 mRNA CTD PMID:23649840 NCBI chr 2:118,848,260...118,859,887
Ensembl chr 2:118,848,260...118,859,874
JBrowse link
G Ccdc82 coiled-coil domain containing 82 increases expression ISO Vincristine results in increased expression of CCDC82 mRNA CTD PMID:23649840 NCBI chr 9:13,246,573...13,292,867
Ensembl chr 9:13,246,536...13,292,867
JBrowse link
G Cchcr1 coiled-coil alpha-helical rod protein 1 decreases expression ISO Vincristine results in decreased expression of CCHCR1 mRNA CTD PMID:23649840 NCBI chr17:35,827,914...35,841,912
Ensembl chr17:35,827,997...35,841,912
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Vincristine results in increased expression of CCL1 mRNA CTD PMID:23649840 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Vincristine results in increased expression of CCL2 mRNA CTD PMID:20624997 PMID:23649840 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Vincristine results in increased expression of CCL20 mRNA CTD PMID:23649840 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Vincristine results in increased expression of CCL22 mRNA CTD PMID:23649840 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Vincristine results in increased expression of CCL4 mRNA CTD PMID:23649840 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Vincristine results in increased expression of CCL5 mRNA CTD PMID:23649840 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccn2 cellular communication network factor 2 decreases response to substance ISO CCN2 mRNA results in decreased susceptibility to Vincristine CTD PMID:24154679 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Ccnb1 cyclin B1 affects response to substance
increases expression
ISO CCNB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of CCNB1 mRNA
CTD PMID:22178383 PMID:23649840 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Vincristine results in increased expression of CCNB2 mRNA CTD PMID:23649840 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Vincristine results in decreased expression of CCNE1 mRNA CTD PMID:23649840 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Vincristine results in decreased expression of CCNE2 mRNA CTD PMID:23649840 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Ccnl1 cyclin L1 decreases expression ISO Vincristine results in decreased expression of CCNL1 mRNA CTD PMID:23649840 NCBI chr 3:65,853,333...65,869,451
Ensembl chr 3:65,853,572...65,865,670
JBrowse link
G Cd109 CD109 antigen increases expression ISO Vincristine results in increased expression of CD109 mRNA CTD PMID:23649840 NCBI chr 9:78,522,828...78,623,542
Ensembl chr 9:78,522,828...78,623,535
JBrowse link
G Cd14 CD14 antigen increases expression ISO Vincristine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd200 CD200 molecule increases expression ISO Vincristine results in increased expression of CD200 mRNA CTD PMID:23649840 NCBI chr16:45,202,474...45,229,419
Ensembl chr16:45,202,498...45,229,416
JBrowse link
G Cd274 CD274 antigen increases expression ISO Vincristine results in increased expression of CD274 mRNA CTD PMID:23649840 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
JBrowse link
G Cd36 CD36 molecule increases expression ISO Vincristine results in increased expression of CD36 mRNA CTD PMID:20624997 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cd40 CD40 antigen increases expression ISO Vincristine results in increased expression of CD40 mRNA CTD PMID:23649840 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd44 CD44 antigen increases expression ISO Vincristine results in increased expression of CD44 mRNA CTD PMID:23649840 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Cd48 CD48 antigen increases expression ISO Vincristine results in increased expression of CD48 mRNA CTD PMID:23649840 NCBI chr 1:171,508,989...171,532,825
Ensembl chr 1:171,509,577...171,532,826
JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement increases expression ISO Vincristine results in increased expression of CD55 mRNA CTD PMID:23649840 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481
JBrowse link
G Cd69 CD69 antigen increases expression ISO Vincristine results in increased expression of CD69 mRNA CTD PMID:23649840 NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399
JBrowse link
G Cd80 CD80 antigen increases expression ISO Vincristine results in increased expression of CD80 mRNA CTD PMID:23649840 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd83 CD83 antigen increases expression ISO Vincristine results in increased expression of CD83 mRNA CTD PMID:23649840 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608
JBrowse link
G Cd86 CD86 antigen increases expression ISO Vincristine results in increased expression of CD86 mRNA CTD PMID:23649840 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression ISO Vincristine results in increased expression of CDC42EP3 mRNA CTD PMID:23649840 NCBI chr17:79,641,152...79,662,520
Ensembl chr17:79,641,156...79,662,520
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression ISO Vincristine results in increased expression of CDC42EP4 mRNA CTD PMID:23649840 NCBI chr11:113,617,676...113,643,369
Ensembl chr11:113,617,676...113,642,707
JBrowse link
G Cdc42se1 CDC42 small effector 1 increases expression ISO Vincristine results in increased expression of CDC42SE1 mRNA CTD PMID:23649840 NCBI chr 3:95,135,735...95,143,735
Ensembl chr 3:95,136,043...95,143,720
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Vincristine results in decreased expression of CDC6 mRNA CTD PMID:23649840 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO Vincristine results in decreased expression of CDCA3 mRNA CTD PMID:23649840 NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664
JBrowse link
G Cdca7 cell division cycle associated 7 decreases expression ISO Vincristine results in decreased expression of CDCA7 mRNA CTD PMID:23649840 NCBI chr 2:72,306,540...72,317,237
Ensembl chr 2:72,306,503...72,317,237
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Vincristine results in increased expression of CDH1 mRNA CTD PMID:23649840 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO Vincristine results in decreased expression of CDK1 mRNA CTD PMID:23649840 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk10 cyclin dependent kinase 10 decreases expression ISO Vincristine results in decreased expression of CDK10 mRNA CTD PMID:23649840 NCBI chr 8:123,951,580...123,958,995
Ensembl chr 8:123,951,581...123,958,989
JBrowse link
G Cdk19 cyclin dependent kinase 19 decreases expression ISO Vincristine results in decreased expression of CDK19 mRNA CTD PMID:23649840 NCBI chr10:40,225,283...40,359,814
Ensembl chr10:40,215,560...40,359,814
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Vincristine results in decreased expression of CDK2 mRNA CTD PMID:23649840 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Vincristine results in increased expression of CDKN1A mRNA
[XL019 compound co-treated with Vincristine] results in increased expression of CDKN1A protein; Resveratrol inhibits the reaction [Vincristine results in increased expression of CDKN1A mRNA]
CTD PMID:20624997 PMID:23649840 PMID:26055805 PMID:29187454 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases response to substance ISO CDKN2A protein results in increased susceptibility to Vincristine CTD PMID:16786135 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C decreases expression ISO Vincristine results in decreased expression of CDKN2C mRNA CTD PMID:23649840 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Vincristine results in increased expression of CEACAM1 mRNA CTD PMID:23649840 NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Vincristine results in increased expression of CEBPB mRNA CTD PMID:16001973 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
JBrowse link
G Celf1 CUGBP, Elav-like family member 1 decreases expression ISO Vincristine results in decreased expression of CELF1 mRNA CTD PMID:23649840 NCBI chr 2:90,770,604...90,849,842
Ensembl chr 2:90,770,727...90,849,842
JBrowse link
G Cenpc1 centromere protein C1 decreases expression ISO Vincristine results in decreased expression of CENPC1 mRNA CTD PMID:23649840 NCBI chr 5:86,159,877...86,214,325
Ensembl chr 5:86,159,883...86,213,442
JBrowse link
G Cenpf centromere protein F decreases expression ISO Vincristine results in decreased expression of CENPF mRNA CTD PMID:23649840 NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283
JBrowse link
G Cenpi centromere protein I decreases expression ISO Vincristine results in decreased expression of CENPI mRNA CTD PMID:23649840 NCBI chr  X:133,206,777...133,263,853
Ensembl chr  X:133,208,833...133,263,388
JBrowse link
G Cenpu centromere protein U decreases expression ISO Vincristine results in decreased expression of CENPU mRNA CTD PMID:23649840 NCBI chr 8:47,005,054...47,033,603
Ensembl chr 8:47,005,063...47,033,042
JBrowse link
G Cep135 centrosomal protein 135 increases expression ISO Vincristine results in increased expression of CEP135 mRNA CTD PMID:23649840 NCBI chr 5:76,736,495...76,794,313
Ensembl chr 5:76,736,545...76,794,313
JBrowse link
G Ces5a carboxylesterase 5A increases expression ISO Vincristine results in increased expression of CES5A mRNA CTD PMID:23649840 NCBI chr 8:94,225,691...94,262,507
Ensembl chr 8:94,225,692...94,262,458
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO Vincristine results in increased expression of CFLAR mRNA CTD PMID:23649840 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression ISO Vincristine results in increased expression of CHD1L mRNA CTD PMID:23649840 NCBI chr 3:97,468,056...97,517,538
Ensembl chr 3:97,468,058...97,517,519
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Vincristine results in decreased expression of CHEK2 mRNA CTD PMID:23649840 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Chm CHM Rab escort protein increases expression ISO Vincristine results in increased expression of CHM mRNA CTD PMID:23649840 NCBI chr  X:111,950,289...112,095,236
Ensembl chr  X:111,950,290...112,095,214
JBrowse link
G Chml choroideremia-like decreases expression ISO Vincristine results in decreased expression of CHML mRNA CTD PMID:23649840 NCBI chr 1:175,509,803...175,520,198
Ensembl chr 1:175,509,803...175,520,467
JBrowse link
G Chtf18 CTF18, chromosome transmission fidelity factor 18 decreases expression ISO Vincristine results in decreased expression of CHTF18 mRNA CTD PMID:23649840 NCBI chr17:25,938,004...25,946,409
Ensembl chr17:25,937,900...25,946,393
JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 decreases response to substance ISO CIAPIN1 protein results in decreased susceptibility to Vincristine CTD PMID:18389626 NCBI chr 8:95,546,446...95,565,454
Ensembl chr 8:95,546,432...95,564,986
JBrowse link
G Clasp2 CLIP associating protein 2 increases expression ISO Vincristine results in increased expression of CLASP2 mRNA CTD PMID:23649840 NCBI chr 9:113,567,776...113,748,765
Ensembl chr 9:113,570,541...113,748,750
JBrowse link
G Clec2h C-type lectin domain family 2, member h decreases expression ISO Vincristine results in decreased expression of CLEC2D mRNA CTD PMID:23649840 NCBI chr 6:128,639,348...128,654,337
Ensembl chr 6:128,639,348...128,654,337
JBrowse link
G Clspn claspin decreases expression ISO Vincristine results in decreased expression of CLSPN mRNA CTD PMID:23649840 NCBI chr 4:126,450,738...126,488,326
Ensembl chr 4:126,450,728...126,487,696
JBrowse link
G Cnksr2 connector enhancer of kinase suppressor of Ras 2 decreases expression ISO Vincristine results in decreased expression of CNKSR2 mRNA CTD PMID:23649840 NCBI chr  X:156,604,426...156,827,454
Ensembl chr  X:156,604,432...156,826,290
JBrowse link
G Cnot3 CCR4-NOT transcription complex, subunit 3 decreases expression ISO Vincristine results in decreased expression of CNOT3 mRNA CTD PMID:23649840 NCBI chr 7:3,646,717...3,664,108
Ensembl chr 7:3,648,267...3,664,108
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like decreases expression ISO Vincristine results in decreased expression of CNOT6L mRNA CTD PMID:23649840 NCBI chr 5:96,218,192...96,312,044
Ensembl chr 5:96,218,192...96,312,030
JBrowse link
G Cntln centlein, centrosomal protein decreases expression ISO Vincristine results in decreased expression of CNTLN mRNA CTD PMID:23649840 NCBI chr 4:84,800,024...85,050,160
Ensembl chr 4:84,802,546...85,050,158
JBrowse link
G Col15a1 collagen, type XV, alpha 1 decreases response to substance ISO COL15A1 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167
JBrowse link
G Col1a2 collagen, type I, alpha 2 increases response to substance ISO COL1A2 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases response to substance ISO COL3A1 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Col5a2 collagen, type V, alpha 2 decreases response to substance ISO COL5A2 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 decreases expression ISO Vincristine results in decreased expression of COMTD1 mRNA CTD PMID:23649840 NCBI chr14:21,895,929...21,898,978
Ensembl chr14:21,895,923...21,899,045
JBrowse link
G Cp ceruloplasmin increases expression ISO Vincristine results in increased expression of CP mRNA CTD PMID:20624997 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 increases expression ISO Vincristine results in increased expression of CPEB2 mRNA CTD PMID:23649840 NCBI chr 5:43,382,692...43,447,067
Ensembl chr 5:43,390,513...43,447,067
JBrowse link
G Cpne3 copine III decreases expression ISO Vincristine results in decreased expression of CPNE3 mRNA CTD PMID:23649840 NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 decreases expression ISO Vincristine results in decreased expression of CPSF6 mRNA CTD PMID:23649840 NCBI chr10:117,180,572...117,212,903
Ensembl chr10:117,180,578...117,215,920
JBrowse link
G Crebbp CREB binding protein increases expression ISO Vincristine results in increased expression of CREBBP mRNA CTD PMID:23649840 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861
JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO Vincristine results in increased expression of CREBRF mRNA CTD PMID:23649840 NCBI chr17:26,918,716...26,995,611
Ensembl chr17:26,934,624...26,995,609
JBrowse link
G Crebzf CREB/ATF bZIP transcription factor decreases expression ISO Vincristine results in decreased expression of CREBZF mRNA CTD PMID:23649840 NCBI chr 7:90,091,942...90,097,590
Ensembl chr 7:90,091,937...90,097,202
JBrowse link
G Crtap cartilage associated protein decreases expression ISO Vincristine results in decreased expression of CRTAP mRNA CTD PMID:23649840 NCBI chr 9:114,204,204...114,219,743
Ensembl chr 9:114,204,202...114,219,743
JBrowse link
G Crtc3 CREB regulated transcription coactivator 3 increases expression ISO Vincristine results in increased expression of CRTC3 mRNA CTD PMID:23649840 NCBI chr 7:80,236,375...80,339,443
Ensembl chr 7:80,236,375...80,338,625
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression ISO Vincristine results in decreased expression of CSAD mRNA CTD PMID:23649840 NCBI chr15:102,085,432...102,112,685
Ensembl chr15:102,085,434...102,113,159
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases expression ISO Vincristine results in increased expression of CSF2 mRNA CTD PMID:23649840 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression ISO Vincristine results in increased expression of CSNK1A1 mRNA CTD PMID:23649840 NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132
JBrowse link
G Csnk1g1 casein kinase 1, gamma 1 increases expression ISO Vincristine results in increased expression of CSNK1G1 mRNA CTD PMID:23649840 NCBI chr 9:65,816,235...65,952,297
Ensembl chr 9:65,816,206...65,952,297
JBrowse link
G Csta2 cystatin A family member 2 increases expression ISO Vincristine results in increased expression of CSTA mRNA CTD PMID:23649840 NCBI chr16:36,041,932...36,077,813
Ensembl chr16:36,041,838...36,077,810
JBrowse link
G Cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 decreases expression ISO Vincristine results in decreased expression of CSTF1 mRNA CTD PMID:23649840 NCBI chr 2:172,212,591...172,224,369
Ensembl chr 2:172,212,601...172,224,368
JBrowse link
G Ctc1 CTS telomere maintenance complex component 1 decreases expression ISO Vincristine results in decreased expression of CTC1 mRNA CTD PMID:23649840 NCBI chr11:68,906,014...68,927,299
Ensembl chr11:68,906,737...68,927,299
JBrowse link
G Cth cystathionine gamma lyase increases expression ISO Vincristine results in increased expression of CTH mRNA CTD PMID:23649840 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
JBrowse link
G Ctnnal1 catenin alpha like 1 decreases expression ISO Vincristine results in decreased expression of CTNNAL1 mRNA CTD PMID:23649840 NCBI chr 4:56,810,935...56,865,370
Ensembl chr 4:56,810,935...56,865,188
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases response to substance
ISO Vincristine results in increased expression of CTNNB1 mRNA
CTNNB1 results in decreased susceptibility to Vincristine
CTD PMID:22000491 PMID:23649840 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cul4a cullin 4A increases expression ISO Vincristine results in increased expression of CUL4A mRNA CTD PMID:23649840 NCBI chr 8:13,155,623...13,197,940
Ensembl chr 8:13,155,621...13,197,940
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Vincristine results in increased expression of CXCL10 mRNA CTD PMID:23649840 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 increases expression ISO Vincristine results in increased expression of CXCL11 mRNA CTD PMID:23649840 NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions
EXP Vincristine results in increased expression of CXCL12 mRNA
KN 93 inhibits the reaction [Vincristine results in increased expression of CXCL12 mRNA]
CTD PMID:34286406 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Vincristine results in increased expression of CXCL8 mRNA CTD PMID:23649840 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO Vincristine results in increased expression of CXCL9 mRNA CTD PMID:23649840 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases expression ISO Vincristine results in increased expression of CYLD mRNA CTD PMID:23649840 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases response to substance ISO CYP2C8 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases response to substance ISO CYP2C9 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions
increases metabolic processing
ISO [CYP3A5 gene polymorphism results in increased activity of CYP3A5 protein] which results in increased metabolism of Vincristine
CYP3A5 protein results in increased metabolism of Vincristine
CTD PMID:21225912 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Vincristine results in increased expression of CYP4F3 mRNA CTD PMID:23649840 NCBI chr 8:72,742,326...72,763,512
Ensembl chr 8:72,742,326...72,763,470
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Vincristine results in decreased expression of CYP4V2 mRNA CTD PMID:23649840 NCBI chr 8:45,758,838...45,786,200
Ensembl chr 8:45,757,981...45,786,253
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 decreases expression ISO Vincristine results in decreased expression of CYSLTR1 mRNA CTD PMID:23649840 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285
JBrowse link
G Daam1 dishevelled associated activator of morphogenesis 1 increases expression ISO Vincristine results in increased expression of DAAM1 mRNA CTD PMID:23649840 NCBI chr12:71,877,834...72,039,150
Ensembl chr12:71,877,852...72,039,107
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 increases expression ISO Vincristine results in increased expression of DCAF8 mRNA CTD PMID:23649840 NCBI chr 1:171,975,574...172,023,959
Ensembl chr 1:171,975,651...172,024,572
JBrowse link
G Dcn decorin decreases response to substance ISO DCN mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005
JBrowse link
G Dcun1d1 defective in cullin neddylation 1 domain containing 1 increases expression ISO Vincristine results in increased expression of DCUN1D1 mRNA CTD PMID:23649840 NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 decreases expression ISO Vincristine results in decreased expression of DCUN1D4 mRNA CTD PMID:23649840 NCBI chr 5:73,638,353...73,718,137
Ensembl chr 5:73,638,343...73,718,137
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Vincristine results in increased expression of DDIT3 mRNA CTD PMID:23649840 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Ddx50 DExD box helicase 50 increases expression ISO Vincristine results in increased expression of DDX50 mRNA CTD PMID:23649840 NCBI chr10:62,451,571...62,487,260
Ensembl chr10:62,451,674...62,486,997
JBrowse link
G Ddx52 DExD box helicase 52 increases expression ISO Vincristine results in increased expression of DDX52 mRNA CTD PMID:23649840 NCBI chr11:83,831,659...83,853,914
Ensembl chr11:83,832,888...83,853,914
JBrowse link
G Ddx60 DExD/H box helicase 60 increases expression ISO Vincristine results in increased expression of DDX60 mRNA CTD PMID:23649840 NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278
JBrowse link
G Dennd5a DENN domain containing 5A increases expression ISO Vincristine results in increased expression of DENND5A mRNA CTD PMID:23649840 NCBI chr 7:109,492,987...109,559,677
Ensembl chr 7:109,492,987...109,559,677
JBrowse link
G Dgcr8 DGCR8, microprocessor complex subunit decreases expression ISO Vincristine results in decreased expression of DGCR8 mRNA CTD PMID:23649840 NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Vincristine results in decreased expression of DHFR mRNA CTD PMID:23649840 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases expression ISO Vincristine results in decreased expression of DHRS11 mRNA CTD PMID:23649840 NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820
JBrowse link
G Dhrs2 dehydrogenase/reductase member 2 increases expression ISO Vincristine results in increased expression of DHRS2 mRNA CTD PMID:23649840 NCBI chr14:55,459,464...55,478,897
Ensembl chr14:55,459,464...55,478,892
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases expression ISO Vincristine results in increased expression of DHRS7 mRNA CTD PMID:23649840 NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases expression ISO Vincristine results in decreased expression of DIABLO mRNA CTD PMID:23649840 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Dido1 death inducer-obliterator 1 decreases expression ISO Vincristine results in decreased expression of DIDO1 mRNA CTD PMID:23649840 NCBI chr 2:180,299,757...180,351,886
Ensembl chr 2:180,299,757...180,351,792
JBrowse link
G Dip2a disco interacting protein 2 homolog A increases expression ISO Vincristine results in increased expression of DIP2A mRNA CTD PMID:23649840 NCBI chr10:76,098,581...76,181,194
Ensembl chr10:76,095,263...76,181,125
JBrowse link
G Dmd dystrophin, muscular dystrophy increases expression ISO Vincristine results in increased expression of DMD mRNA CTD PMID:23649840 NCBI chr  X:81,858,244...84,248,656
Ensembl chr  X:81,992,476...84,249,747
JBrowse link
G Dna2 DNA replication helicase/nuclease 2 decreases expression ISO Vincristine results in decreased expression of DNA2 mRNA CTD PMID:23649840 NCBI chr10:62,782,762...62,809,967
Ensembl chr10:62,782,805...62,809,964
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases expression ISO Vincristine results in decreased expression of DNAJB1 mRNA CTD PMID:23649840 NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 increases expression ISO Vincristine results in increased expression of DNAJC7 mRNA CTD PMID:23649840 NCBI chr11:100,473,644...100,511,030
Ensembl chr11:100,473,644...100,511,014
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 decreases expression ISO Vincristine results in decreased expression of DNASE1L3 mRNA CTD PMID:23649840 NCBI chr14:14,475,014...14,504,586
Ensembl chr14:14,475,200...14,505,240
JBrowse link
G Dnmbp dynamin binding protein decreases expression ISO Vincristine results in decreased expression of DNMBP mRNA CTD PMID:23649840 NCBI chr19:43,835,259...43,930,930
Ensembl chr19:43,835,260...43,928,630
JBrowse link
G Dock4 dedicator of cytokinesis 4 increases expression ISO Vincristine results in increased expression of DOCK4 mRNA CTD PMID:23649840 NCBI chr12:40,495,956...40,896,873
Ensembl chr12:40,495,951...40,896,873
JBrowse link
G Dock8 dedicator of cytokinesis 8 decreases expression ISO Vincristine results in decreased expression of DOCK8 mRNA CTD PMID:23649840 NCBI chr19:24,976,753...25,179,796
Ensembl chr19:24,976,898...25,179,796
JBrowse link
G Dok4 docking protein 4 increases expression ISO Vincristine results in increased expression of DOK4 mRNA CTD PMID:23649840 NCBI chr 8:95,590,456...95,602,940
Ensembl chr 8:95,590,456...95,602,958
JBrowse link
G Donson downstream neighbor of SON decreases expression ISO Vincristine results in decreased expression of DONSON mRNA CTD PMID:23649840 NCBI chr16:91,463,744...91,485,702
Ensembl chr16:91,473,696...91,485,658
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO Vincristine results in decreased expression of DPP4 mRNA CTD PMID:23649840 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases response to substance ISO DPYD gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 increases expression ISO Vincristine results in increased expression of DRAM1 mRNA CTD PMID:23649840 NCBI chr10:88,158,663...88,200,218
Ensembl chr10:88,158,666...88,214,942
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase decreases expression ISO Vincristine results in decreased expression of DTL mRNA CTD PMID:23649840 NCBI chr 1:191,269,468...191,307,656
Ensembl chr 1:191,269,468...191,307,656
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Vincristine results in increased expression of DUSP1 mRNA CTD PMID:23649840 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Vincristine results in increased expression of DUSP10 mRNA CTD PMID:23649840 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
JBrowse link
G Dusp16 dual specificity phosphatase 16 increases expression ISO Vincristine results in increased expression of DUSP16 mRNA CTD PMID:23649840 NCBI chr 6:134,692,431...134,769,687
Ensembl chr 6:134,692,431...134,769,588
JBrowse link
G Dusp2 dual specificity phosphatase 2 increases expression ISO Vincristine results in increased expression of DUSP2 mRNA CTD PMID:23649840 NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Vincristine results in increased expression of DUSP4 mRNA CTD PMID:23649840 NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048
JBrowse link
G Dynlt2a1 dynein light chain Tctex-type 2A1 decreases expression ISO Vincristine results in decreased expression of DYNLT2 mRNA CTD PMID:23649840 NCBI chr17:15,233,025...15,261,821
Ensembl chr17:15,247,414...15,261,750
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO Vincristine results in decreased expression of E2F8 mRNA CTD PMID:23649840 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344
JBrowse link
G Ebf1 early B cell factor 1 increases expression ISO Vincristine results in increased expression of EBF1 mRNA CTD PMID:23649840 NCBI chr11:44,502,738...44,898,923
Ensembl chr11:44,508,144...44,898,918
JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Vincristine results in increased expression of EDNRB mRNA CTD PMID:20624997 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Efna4 ephrin A4 decreases expression ISO Vincristine results in decreased expression of EFNA4 mRNA CTD PMID:23649840 NCBI chr 3:89,240,700...89,245,335
Ensembl chr 3:89,240,697...89,245,335
JBrowse link
G Egfl6 EGF-like-domain, multiple 6 decreases response to substance ISO EGFL6 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr  X:165,306,003...165,368,712
Ensembl chr  X:165,306,003...165,368,716
JBrowse link
G Egr1 early growth response 1 increases expression ISO Vincristine results in increased expression of EGR1 mRNA CTD PMID:12706485 PMID:23649840 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Egr3 early growth response 3 increases expression ISO Vincristine results in increased expression of EGR3 mRNA CTD PMID:23649840 NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063
JBrowse link
G Ehbp1l1 EH domain binding protein 1-like 1 decreases expression ISO Vincristine results in decreased expression of EHBP1L1 mRNA CTD PMID:23649840 NCBI chr19:5,757,397...5,776,504
Ensembl chr19:5,757,404...5,776,345
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO Vincristine results in decreased expression of EIF1 mRNA CTD PMID:23649840 NCBI chr11:100,210,775...100,212,925
Ensembl chr11:100,210,711...100,212,922
JBrowse link
G Eif1ad eukaryotic translation initiation factor 1A domain containing decreases expression ISO Vincristine results in decreased expression of EIF1AD mRNA CTD PMID:23649840 NCBI chr19:5,416,841...5,421,546
Ensembl chr19:5,416,769...5,421,554
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions
ISO Vincristine results in increased expression of EIF2AK3 mRNA
Quercetin inhibits the reaction [Vincristine results in increased expression of EIF2AK3 mRNA]
CTD PMID:33038355 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B decreases expression ISO Vincristine results in decreased expression of EIF3B mRNA CTD PMID:23649840 NCBI chr 5:140,405,060...140,429,113
Ensembl chr 5:140,405,083...140,429,115
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M increases expression ISO Vincristine results in increased expression of EIF3M mRNA CTD PMID:23649840 NCBI chr 2:104,830,001...104,847,372
Ensembl chr 2:104,830,001...104,847,425
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases expression ISO Vincristine results in increased expression of EIF4A1 mRNA CTD PMID:23649840 NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO Vincristine results in decreased expression of EIF4A2 mRNA CTD PMID:23649840 NCBI chr16:22,924,846...22,932,882
Ensembl chr16:22,926,194...22,932,886
JBrowse link
G Elf3 E74-like factor 3 increases expression ISO Vincristine results in increased expression of ELF3 mRNA CTD PMID:23649840 NCBI chr 1:135,181,312...135,186,210
Ensembl chr 1:135,181,313...135,186,306
JBrowse link
G Elk3 ELK3, member of ETS oncogene family increases expression ISO Vincristine results in increased expression of ELK3 mRNA CTD PMID:23649840 NCBI chr10:93,083,277...93,147,021
Ensembl chr10:93,083,276...93,146,997
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 decreases expression ISO Vincristine results in decreased expression of EME2 mRNA CTD PMID:23649840 NCBI chr17:25,111,126...25,114,061
Ensembl chr17:25,107,460...25,114,061
JBrowse link
G Eml6 echinoderm microtubule associated protein like 6 decreases expression ISO Vincristine results in decreased expression of EML6 mRNA CTD PMID:23649840 NCBI chr11:29,693,044...29,976,044
Ensembl chr11:29,693,048...29,976,033
JBrowse link
G Enox1 ecto-NOX disulfide-thiol exchanger 1 increases expression ISO Vincristine results in increased expression of ENOX1 mRNA CTD PMID:23649840 NCBI chr14:77,393,790...77,959,203
Ensembl chr14:77,394,203...77,959,200
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Vincristine results in increased expression of ENPP2 mRNA CTD PMID:23649840 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288
JBrowse link
G Ensa endosulfine alpha decreases expression ISO Vincristine results in decreased expression of ENSA mRNA CTD PMID:23649840 NCBI chr 3:95,532,291...95,539,428
Ensembl chr 3:95,532,304...95,539,413
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 increases expression ISO Vincristine results in increased expression of ENTPD2 mRNA CTD PMID:23649840 NCBI chr 2:25,285,886...25,291,335
Ensembl chr 2:25,285,886...25,291,333
JBrowse link
G Eomes eomesodermin decreases expression ISO Vincristine results in decreased expression of EOMES mRNA CTD PMID:23649840 NCBI chr 9:118,307,259...118,315,176
Ensembl chr 9:118,307,280...118,315,200
JBrowse link
G Epg5 ectopic P-granules 5 autophagy tethering factor increases expression ISO Vincristine results in increased expression of EPG5 mRNA CTD PMID:23649840 NCBI chr18:77,981,618...78,080,539
Ensembl chr18:77,981,680...78,078,228
JBrowse link
G Ephb1 Eph receptor B1 decreases expression ISO Vincristine results in decreased expression of EPHB1 mRNA CTD PMID:23649840 NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal decreases expression EXP Vincristine results in decreased expression of EPHX1 mRNA CTD PMID:21382384 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 decreases expression ISO Vincristine results in decreased expression of EPM2AIP1 mRNA CTD PMID:23649840 NCBI chr 9:111,100,913...111,108,161
Ensembl chr 9:111,100,997...111,108,161
JBrowse link
G Epor erythropoietin receptor decreases expression ISO Vincristine results in decreased expression of EPOR mRNA CTD PMID:23649840 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802
JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 increases expression ISO Vincristine results in increased expression of EPRS1 mRNA CTD PMID:20624997 NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557
JBrowse link
G Epsti1 epithelial stromal interaction 1 increases expression ISO Vincristine results in increased expression of EPSTI1 mRNA CTD PMID:23649840 NCBI chr14:78,141,679...78,240,096
Ensembl chr14:78,141,679...78,240,097
JBrowse link
G Erich3 glutamate rich 3 decreases expression ISO Vincristine results in decreased expression of ERICH3 mRNA CTD PMID:23649840 NCBI chr 3:154,416,770...154,454,649
Ensembl chr 3:154,369,496...154,473,427
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Vincristine results in increased expression of ERN1 mRNA] CTD PMID:33038355 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 decreases expression ISO Vincristine results in decreased expression of ESCO2 mRNA CTD PMID:23649840 NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443
JBrowse link
G Esd esterase D/formylglutathione hydrolase decreases expression ISO Vincristine results in decreased expression of ESD mRNA CTD PMID:23649840 NCBI chr14:74,969,591...74,988,205
Ensembl chr14:74,969,737...74,988,205
JBrowse link
G Esm1 endothelial cell-specific molecule 1 decreases expression ISO Vincristine results in decreased expression of ESM1 mRNA CTD PMID:20624997 NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression
ISO bisphenol A inhibits the reaction [Vincristine results in decreased expression of ESR1 mRNA]; bisphenol A inhibits the reaction [Vincristine results in decreased expression of ESR1 protein]; Diethylhexyl Phthalate inhibits the reaction [Vincristine results in decreased expression of ESR1 mRNA]; Diethylhexyl Phthalate inhibits the reaction [Vincristine results in decreased expression of ESR1 protein]; Vincristine binds to and results in decreased activity of ESR1 protein
Vincristine results in decreased expression of ESR1 mRNA; Vincristine results in decreased expression of ESR1 protein
CTD PMID:25752796 PMID:35263089 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
decreases expression
ISO bisphenol A inhibits the reaction [Vincristine results in decreased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [Vincristine results in decreased expression of ESR2 protein]; Diethylhexyl Phthalate inhibits the reaction [Vincristine results in decreased expression of ESR2 mRNA]; Diethylhexyl Phthalate inhibits the reaction [Vincristine results in decreased expression of ESR2 protein]
Vincristine results in decreased expression of ESR2 mRNA; Vincristine results in decreased expression of ESR2 protein
CTD PMID:35263089 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Evc EvC ciliary complex subunit 1 increases expression ISO Vincristine results in increased expression of EVC mRNA CTD PMID:23649840 NCBI chr 5:37,446,314...37,495,489
Ensembl chr 5:37,446,442...37,494,238
JBrowse link
G Exo1 exonuclease 1 decreases expression ISO Vincristine results in decreased expression of EXO1 mRNA CTD PMID:23649840 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
JBrowse link
G Exog exo/endonuclease G decreases expression ISO Vincristine results in decreased expression of EXOG mRNA CTD PMID:23649840 NCBI chr 9:119,274,026...119,294,584
Ensembl chr 9:119,274,009...119,294,583
JBrowse link
G Ext1 exostosin glycosyltransferase 1 increases expression ISO Vincristine results in increased expression of EXT1 mRNA CTD PMID:23649840 NCBI chr15:52,931,657...53,209,579
Ensembl chr15:52,927,434...53,209,555
JBrowse link
G F2 coagulation factor II affects expression ISO Vincristine affects the expression of F2 protein CTD PMID:12542493 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G F3 coagulation factor III increases expression ISO Vincristine results in increased expression of F3 mRNA; Vincristine results in increased expression of F3 protein CTD PMID:12542493 PMID:20624997 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fam13b family with sequence similarity 13, member B increases expression ISO Vincristine results in increased expression of FAM13B mRNA CTD PMID:23649840 NCBI chr18:34,573,624...34,656,096
Ensembl chr18:34,575,404...34,639,884
JBrowse link
G Fam13c family with sequence similarity 13, member C increases expression ISO Vincristine results in increased expression of FAM13C mRNA CTD PMID:23649840 NCBI chr10:70,274,981...70,394,566
Ensembl chr10:70,276,311...70,394,566
JBrowse link
G Fam171b family with sequence similarity 171, member B decreases expression ISO Vincristine results in decreased expression of FAM171B mRNA CTD PMID:23649840 NCBI chr 2:83,642,889...83,713,878
Ensembl chr 2:83,642,980...83,713,830
JBrowse link
G Fam174a family with sequence similarity 174, member A increases expression ISO Vincristine results in increased expression of FAM174A mRNA CTD PMID:23649840 NCBI chr 1:95,241,353...95,263,009
Ensembl chr 1:95,241,348...95,263,009
JBrowse link
G Fam76b family with sequence similarity 76, member B decreases expression ISO Vincristine results in decreased expression of FAM76B mRNA CTD PMID:23649840 NCBI chr 9:13,738,490...13,766,033
Ensembl chr 9:13,739,012...13,766,283
JBrowse link
G Fam81a family with sequence similarity 81, member A decreases expression ISO Vincristine results in decreased expression of FAM81A mRNA CTD PMID:23649840 NCBI chr 9:69,996,586...70,049,840
Ensembl chr 9:69,995,793...70,049,842
JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO Vincristine results in decreased expression of FAM83D mRNA CTD PMID:23649840 NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
JBrowse link
G Fancf Fanconi anemia, complementation group F decreases expression ISO Vincristine results in decreased expression of FANCF mRNA CTD PMID:23649840 NCBI chr 7:51,510,325...51,512,015
Ensembl chr 7:51,510,325...51,512,015
JBrowse link
G Fancg Fanconi anemia, complementation group G decreases expression ISO Vincristine results in decreased expression of FANCG mRNA CTD PMID:23649840 NCBI chr 4:43,002,337...43,010,565
Ensembl chr 4:43,002,343...43,010,506
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Vincristine results in increased expression of FAS mRNA CTD PMID:23649840 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand increases expression ISO Vincristine results in increased expression of FASLG protein CTD PMID:11716366 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fastkd2 FAST kinase domains 2 decreases expression ISO Vincristine results in decreased expression of FASTKD2 mRNA CTD PMID:23649840 NCBI chr 1:63,769,758...63,792,544
Ensembl chr 1:63,769,773...63,793,814
JBrowse link
G Fbxl20 F-box and leucine-rich repeat protein 20 decreases expression ISO Vincristine results in decreased expression of FBXL20 mRNA CTD PMID:23649840 NCBI chr11:97,973,380...98,042,014
Ensembl chr11:97,973,382...98,041,229
JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 decreases expression ISO Vincristine results in decreased expression of FBXL4 mRNA CTD PMID:23649840 NCBI chr 4:22,357,526...22,434,091
Ensembl chr 4:22,357,543...22,434,091
JBrowse link
G Fbxo33 F-box protein 33 decreases expression ISO Vincristine results in decreased expression of FBXO33 mRNA CTD PMID:23649840 NCBI chr12:59,247,441...59,268,747
Ensembl chr12:59,247,441...59,266,511
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO Vincristine results in decreased expression of FBXO5 mRNA CTD PMID:23649840 NCBI chr10:5,749,155...5,755,465
Ensembl chr10:5,749,160...5,755,600
JBrowse link
G Fbxo9 f-box protein 9 decreases expression ISO Vincristine results in decreased expression of FBXO9 mRNA CTD PMID:23649840 NCBI chr 9:77,988,781...78,016,347
Ensembl chr 9:77,988,781...78,016,347
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb increases expression ISO Vincristine results in increased expression of FCGR2B mRNA CTD PMID:20624997 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Vincristine results in increased expression of FDFT1 mRNA CTD PMID:23649840 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
JBrowse link
G Fermt2 fermitin family member 2 increases expression ISO Vincristine results in increased expression of FERMT2 mRNA CTD PMID:23649840 NCBI chr14:45,696,252...45,767,767
Ensembl chr14:45,696,252...45,767,575
JBrowse link
G Ffar2 free fatty acid receptor 2 decreases expression ISO Vincristine results in decreased expression of FFAR2 mRNA CTD PMID:23649840 NCBI chr 7:30,517,778...30,523,200
Ensembl chr 7:30,517,773...30,523,200
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression ISO Vincristine results in decreased expression of FGR mRNA CTD PMID:23649840 NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221
JBrowse link
G Flot2 flotillin 2 decreases expression ISO Vincristine results in decreased expression of FLOT2 mRNA CTD PMID:23649840 NCBI chr11:77,928,757...77,951,260
Ensembl chr11:77,928,757...77,951,260
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 decreases expression ISO Vincristine results in decreased expression of FLT1 mRNA CTD PMID:23649840 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
JBrowse link
G Fmnl3 formin-like 3 increases expression ISO Vincristine results in increased expression of FMNL3 mRNA CTD PMID:23649840 NCBI chr15:99,215,091...99,268,375
Ensembl chr15:99,215,106...99,268,363
JBrowse link
G Fnbp1 formin binding protein 1 increases expression ISO Vincristine results in increased expression of FNBP1 mRNA CTD PMID:23649840 NCBI chr 2:30,916,218...31,032,046
Ensembl chr 2:30,916,218...31,032,020
JBrowse link
G Fnbp4 formin binding protein 4 increases expression ISO Vincristine results in increased expression of FNBP4 mRNA CTD PMID:23649840 NCBI chr 2:90,575,793...90,611,365
Ensembl chr 2:90,575,714...90,611,365
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Vincristine results in increased expression of FOS protein CTD PMID:18930597 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fosl2 fos-like antigen 2 increases expression ISO Vincristine results in increased expression of FOSL2 mRNA CTD PMID:23649840 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
JBrowse link
G Foxk2 forkhead box K2 decreases expression ISO Vincristine results in decreased expression of FOXK2 mRNA CTD PMID:23649840 NCBI chr11:121,150,805...121,200,726
Ensembl chr11:121,150,816...121,200,722
JBrowse link
G Foxo1 forkhead box O1 decreases expression
multiple interactions
ISO Vincristine results in decreased expression of FOXO1 mRNA
Quercetin inhibits the reaction [Vincristine results in decreased expression of FOXO1 mRNA]
CTD PMID:33038355 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxp1 forkhead box P1 increases expression ISO Vincristine results in increased expression of FOXP1 mRNA CTD PMID:23649840 NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682
JBrowse link
G Fry FRY microtubule binding protein decreases expression ISO Vincristine results in decreased expression of FRY mRNA CTD PMID:23649840 NCBI chr 5:150,042,083...150,421,218
Ensembl chr 5:150,042,110...150,421,218
JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Vincristine results in increased expression of FSCN1 mRNA CTD PMID:23649840 NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940
JBrowse link
G Fsd1l fibronectin type III and SPRY domain containing 1-like increases expression ISO Vincristine results in increased expression of FSD1L mRNA CTD PMID:23649840 NCBI chr 4:53,631,383...53,707,009
Ensembl chr 4:53,631,471...53,707,009
JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 decreases expression ISO Vincristine results in decreased expression of FUBP1 mRNA CTD PMID:23649840 NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463
JBrowse link
G Fut11 fucosyltransferase 11 decreases expression ISO Vincristine results in decreased expression of FUT11 mRNA CTD PMID:23649840 NCBI chr14:20,745,036...20,750,265
Ensembl chr14:20,745,036...20,751,084
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Vincristine results in increased expression of G3BP1 mRNA CTD PMID:23649840 NCBI chr11:55,360,521...55,391,722
Ensembl chr11:55,360,511...55,395,664
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Vincristine results in increased expression of GADD45A mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO Vincristine results in increased expression of GADD45B mRNA CTD PMID:20624997 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO Vincristine results in increased expression of GADD45G mRNA CTD PMID:20624997 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
JBrowse link
G Garin1b golgi associated RAB2 interactor 1B increases expression ISO Vincristine results in increased expression of GARIN1B mRNA CTD PMID:23649840 NCBI chr 6:29,313,468...29,336,021
Ensembl chr 6:29,319,139...29,336,018
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase decreases expression ISO Vincristine results in decreased expression of GART mRNA CTD PMID:23649840 NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840
JBrowse link
G Gas7 growth arrest specific 7 decreases expression ISO Vincristine results in decreased expression of GAS7 mRNA CTD PMID:20624997 NCBI chr11:67,344,083...67,579,818
Ensembl chr11:67,345,917...67,575,800
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression ISO Vincristine results in increased expression of GBP2 mRNA CTD PMID:23649840 NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769
JBrowse link
G Gbp2b guanylate binding protein 2b increases expression ISO Vincristine results in increased expression of GBP1 mRNA CTD PMID:23649840 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940
JBrowse link
G Gbp9 guanylate-binding protein 9 decreases expression ISO Vincristine results in decreased expression of GBP6 mRNA CTD PMID:23649840 NCBI chr 5:105,224,331...105,258,255
Ensembl chr 5:105,225,496...105,287,405
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine CTD PMID:10900222 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
decreases expression
ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine
Vincristine results in decreased expression of GCLM mRNA
CTD PMID:10900222 PMID:23649840 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Vincristine results in increased expression of GDF15 mRNA CTD PMID:23649840 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
ISO
EXP
Vincristine results in increased expression of GFAP protein
Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of GFAP protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of GFAP protein]
Quercetin inhibits the reaction [Vincristine results in increased expression of GFAP protein]
CTD PMID:33038355 PMID:34286406 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gfi1 growth factor independent 1 transcription repressor decreases expression ISO Vincristine results in decreased expression of GFI1 mRNA CTD PMID:23649840 NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 increases expression ISO Vincristine results in increased expression of GFM1 mRNA CTD PMID:23649840 NCBI chr 3:67,337,448...67,382,401
Ensembl chr 3:67,337,429...67,383,862
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
EXP Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of GJA1 mRNA]; Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of GJA1 protein]; gap 27 peptide inhibits the reaction [Vincristine results in increased expression of GJA1 mRNA]; gap 27 peptide inhibits the reaction [Vincristine results in increased expression of GJA1 protein]; GJA1 protein promotes the reaction [Vincristine results in increased secretion of IL1B protein]; GJA1 protein promotes the reaction [Vincristine results in increased secretion of IL6 protein]; KN 62 inhibits the reaction [Vincristine results in increased expression of GJA1 protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of GJA1 mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of GJA1 protein]; zinc chloride inhibits the reaction [Vincristine results in increased expression of GJA1 protein]
Vincristine results in increased expression of GJA1 mRNA; Vincristine results in increased expression of GJA1 protein
CTD PMID:34286406 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Gjc1 gap junction protein, gamma 1 decreases expression ISO Vincristine results in decreased expression of GJC1 mRNA CTD PMID:23649840 NCBI chr11:102,690,303...102,710,512
Ensembl chr11:102,690,405...102,710,526
JBrowse link
G Gli1 GLI-Kruppel family member GLI1 increases response to substance ISO GLI1 gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
JBrowse link
G Glipr1 GLI pathogenesis related 1 increases expression ISO Vincristine results in increased expression of GLIPR1 mRNA CTD PMID:23649840 NCBI chr10:111,821,353...111,838,539
Ensembl chr10:111,821,353...111,838,536
JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Vincristine results in increased expression of TP53I3 mRNA CTD PMID:23649840 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142
JBrowse link
G Gmfb glia maturation factor, beta increases expression ISO Vincristine results in increased expression of GMFB mRNA CTD PMID:23649840 NCBI chr14:47,045,606...47,059,711
Ensembl chr14:47,045,606...47,059,699
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B decreases expression ISO Vincristine results in decreased expression of GMPPB mRNA CTD PMID:23649840 NCBI chr 9:107,926,490...107,929,119
Ensembl chr 9:107,926,441...107,930,000
JBrowse link
G Gna15 guanine nucleotide binding protein, alpha 15 increases expression ISO Vincristine results in increased expression of GNA15 mRNA CTD PMID:23649840 NCBI chr10:81,338,147...81,360,283
Ensembl chr10:81,338,140...81,360,059
JBrowse link
G Gng2 guanine nucleotide binding protein (G protein), gamma 2 increases expression ISO Vincristine results in increased expression of GNG2 mRNA CTD PMID:23649840 NCBI chr14:19,922,626...20,027,893
Ensembl chr14:19,922,627...20,027,695
JBrowse link
G Gon4l gon-4 like increases expression ISO Vincristine results in increased expression of GON4L mRNA CTD PMID:23649840 NCBI chr 3:88,742,531...88,817,406
Ensembl chr 3:88,742,535...88,817,410
JBrowse link
G Gopc golgi associated PDZ and coiled-coil motif containing decreases expression ISO Vincristine results in decreased expression of GOPC mRNA CTD PMID:23649840 NCBI chr10:52,213,120...52,258,220
Ensembl chr10:52,211,946...52,258,220
JBrowse link
G Gpatch11 G patch domain containing 11 decreases expression ISO Vincristine results in decreased expression of GPATCH11 mRNA CTD PMID:23649840 NCBI chr17:79,142,951...79,155,737
Ensembl chr17:79,142,996...79,155,737
JBrowse link
G Gpatch2 G patch domain containing 2 increases expression ISO Vincristine results in increased expression of GPATCH2 mRNA CTD PMID:23649840 NCBI chr 1:186,946,855...187,103,839
Ensembl chr 1:186,947,705...187,083,901
JBrowse link
G Gpatch2l G patch domain containing 2 like increases expression ISO Vincristine results in increased expression of GPATCH2L mRNA CTD PMID:23649840 NCBI chr12:86,288,569...86,341,439
Ensembl chr12:86,288,632...86,338,558
JBrowse link
G Gpbp1l1 GC-rich promoter binding protein 1-like 1 increases expression ISO Vincristine results in increased expression of GPBP1L1 mRNA CTD PMID:23649840 NCBI chr 4:116,414,357...116,451,099
Ensembl chr 4:116,414,855...116,451,079
JBrowse link
G Gpc3 glypican 3 increases response to substance ISO GPC3 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr  X:51,361,303...51,702,851
Ensembl chr  X:51,361,303...51,702,827
JBrowse link
G Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial decreases expression ISO Vincristine results in decreased expression of GPD2 mRNA CTD PMID:23649840 NCBI chr 2:57,127,690...57,260,731
Ensembl chr 2:57,127,647...57,260,731
JBrowse link
G Gpnmb glycoprotein (transmembrane) nmb increases expression ISO Vincristine results in increased expression of GPNMB mRNA CTD PMID:23649840 NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863
JBrowse link
G Gpr132 G protein-coupled receptor 132 increases expression ISO Vincristine results in increased expression of GPR132 mRNA CTD PMID:23649840 NCBI chr12:112,814,493...112,832,035
Ensembl chr12:112,814,493...112,831,848
JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Vincristine results in increased expression of GPR137B mRNA CTD PMID:23649840 NCBI chr13:13,528,035...13,568,250
Ensembl chr13:13,532,205...13,568,599
JBrowse link
G Gpr180 G protein-coupled receptor 180 decreases expression ISO Vincristine results in decreased expression of GPR180 mRNA CTD PMID:23649840 NCBI chr14:118,374,513...118,401,644
Ensembl chr14:118,374,570...118,400,673
JBrowse link
G Gpr55 G protein-coupled receptor 55 increases expression ISO Vincristine results in increased expression of GPR55 mRNA CTD PMID:23649840 NCBI chr 1:85,860,927...85,924,781
Ensembl chr 1:85,866,039...85,888,729
JBrowse link
G Gpr63 G protein-coupled receptor 63 decreases expression ISO Vincristine results in decreased expression of GPR63 mRNA CTD PMID:23649840 NCBI chr 4:24,966,054...25,012,726
Ensembl chr 4:24,966,407...25,009,233
JBrowse link
G Gpr84 G protein-coupled receptor 84 increases expression ISO Vincristine results in increased expression of GPR84 mRNA CTD PMID:23649840 NCBI chr15:103,216,660...103,219,050
Ensembl chr15:103,216,662...103,219,039
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases activity
ISO Quercetin inhibits the reaction [Vincristine results in increased activity of GPT protein] CTD PMID:36808657 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gramd2b GRAM domain containing 2B increases expression ISO Vincristine results in increased expression of GRAMD2B mRNA CTD PMID:23649840 NCBI chr18:56,533,412...56,636,864
Ensembl chr18:56,533,409...56,636,864
JBrowse link
G Grap2 GRB2-related adaptor protein 2 decreases expression ISO Vincristine results in decreased expression of GRAP2 mRNA CTD PMID:23649840 NCBI chr15:80,456,798...80,537,055
Ensembl chr15:80,456,795...80,537,055
JBrowse link
G Gspt1 G1 to S phase transition 1 increases expression ISO Vincristine results in increased expression of GSPT1 mRNA CTD PMID:23649840 NCBI chr16:11,034,104...11,072,189
Ensembl chr16:11,037,156...11,072,189
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects response to substance
decreases response to substance
multiple interactions
ISO GSTM1 gene polymorphism affects the susceptibility to Vincristine
GSTM1 protein results in decreased susceptibility to Vincristine
Sulfinpyrazone inhibits the reaction [GSTM1 protein results in decreased susceptibility to Vincristine]
CTD PMID:15044619 PMID:15713801 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases response to substance
multiple interactions
ISO GSTP1 protein results in decreased susceptibility to Vincristine
GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]
CTD PMID:10900222 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gtf3c3 general transcription factor IIIC, polypeptide 3 increases expression ISO Vincristine results in increased expression of GTF3C3 mRNA CTD PMID:23649840 NCBI chr 1:54,435,036...54,478,185
Ensembl chr 1:54,435,163...54,478,130
JBrowse link
G Gtpbp3 GTP binding protein 3 decreases expression ISO Vincristine results in decreased expression of GTPBP3 mRNA CTD PMID:23649840 NCBI chr 8:71,938,788...71,952,268
Ensembl chr 8:71,940,747...71,952,227
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [CEP 33779 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein; [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein CTD PMID:28669723 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G H2bc12 H2B clustered histone 12 increases expression ISO Vincristine results in increased expression of H2BC12 mRNA CTD PMID:23649840 NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515
JBrowse link
G H2bc14 H2B clustered histone 14 increases expression ISO Vincristine results in increased expression of H2BC5 mRNA CTD PMID:23649840 NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737
JBrowse link
G H2bc3 H2B clustered histone 3 increases expression ISO Vincristine results in increased expression of H2BC3 mRNA CTD PMID:23649840 NCBI chr13:23,930,717...23,931,206
Ensembl chr13:23,930,717...23,931,224
JBrowse link
G H2bc4 H2B clustered histone 4 increases expression ISO Vincristine results in increased expression of H2BC4 mRNA CTD PMID:23649840 NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891
JBrowse link
G H2bc6 H2B clustered histone 6 increases expression ISO Vincristine results in increased expression of H2BC6 mRNA CTD PMID:23649840 NCBI chr13:23,767,653...23,805,091
Ensembl chr13:23,767,653...23,805,107
JBrowse link
G H3c11 H3 clustered histone 11 decreases expression ISO Vincristine results in decreased expression of H3C7 mRNA CTD PMID:23649840 NCBI chr13:21,967,085...21,967,567
Ensembl chr13:21,967,130...21,967,540
JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Vincristine results in decreased expression of H4C3 mRNA CTD PMID:23649840 NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Vincristine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Haus2 HAUS augmin-like complex, subunit 2 decreases expression ISO Vincristine results in decreased expression of HAUS2 mRNA CTD PMID:23649840 NCBI chr 2:120,439,863...120,452,041
Ensembl chr 2:120,439,864...120,452,041
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain decreases expression ISO Vincristine results in decreased expression of HBB mRNA CTD PMID:23649840
G Hdac1 histone deacetylase 1 decreases expression ISO Vincristine results in decreased expression of HDAC1 protein CTD PMID:27474498 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
JBrowse link
G Hdac4 histone deacetylase 4 decreases expression ISO Vincristine results in decreased expression of HDAC4 protein CTD PMID:27474498 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression ISO Vincristine results in decreased expression of HDAC9 mRNA CTD PMID:23649840 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094
JBrowse link
G Hdhd3 haloacid dehalogenase-like hydrolase domain containing 3 decreases expression ISO Vincristine results in decreased expression of HDHD3 mRNA CTD PMID:23649840 NCBI chr 4:62,417,291...62,420,437
Ensembl chr 4:62,417,245...62,421,704
JBrowse link
G Hectd4 HECT domain E3 ubiquitin protein ligase 4 increases expression ISO Vincristine results in increased expression of HECTD4 mRNA CTD PMID:23649840 NCBI chr 5:121,357,323...121,506,633
Ensembl chr 5:121,358,282...121,506,640
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO Vincristine results in decreased expression of HELLS mRNA CTD PMID:23649840 NCBI chr19:38,913,282...38,958,914
Ensembl chr19:38,919,359...38,959,495
JBrowse link
G Heph hephaestin increases expression ISO Vincristine results in increased expression of HEPH mRNA CTD PMID:23649840 NCBI chr  X:95,499,042...95,618,091
Ensembl chr  X:95,498,965...95,618,091
JBrowse link
G Hhat hedgehog acyltransferase increases expression ISO Vincristine results in increased expression of HHAT mRNA CTD PMID:23649840 NCBI chr 1:192,195,133...192,453,546
Ensembl chr 1:192,179,019...192,453,531
JBrowse link
G Hic1 hypermethylated in cancer 1 decreases expression ISO Vincristine results in decreased expression of HIC1 mRNA CTD PMID:23649840 NCBI chr11:75,052,203...75,059,970
Ensembl chr11:75,055,391...75,060,345
JBrowse link
G Hilpda hypoxia inducible lipid droplet associated decreases expression ISO Vincristine results in decreased expression of HILPDA mRNA CTD PMID:23649840 NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 decreases expression ISO Vincristine results in decreased expression of HINT1 mRNA CTD PMID:23649840 NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327
JBrowse link
G Hint3 histidine triad nucleotide binding protein 3 increases expression ISO Vincristine results in increased expression of HINT3 mRNA CTD PMID:23649840 NCBI chr10:30,479,191...30,499,526
Ensembl chr10:30,484,137...30,505,628
JBrowse link
G Hivep3 human immunodeficiency virus type I enhancer binding protein 3 increases expression ISO Vincristine results in increased expression of HIVEP3 mRNA CTD PMID:23649840 NCBI chr 4:119,590,982...119,992,608
Ensembl chr 4:119,590,981...119,995,242
JBrowse link
G Hlf hepatic leukemia factor increases expression ISO Vincristine results in increased expression of HLF mRNA CTD PMID:23649840 NCBI chr11:90,227,361...90,281,745
Ensembl chr11:90,227,362...90,281,721
JBrowse link
G Hmcn1 hemicentin 1 increases response to substance ISO HMCN1 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 1:150,438,251...150,869,568
Ensembl chr 1:150,438,275...150,869,186
JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO Vincristine results in decreased expression of HMGA2 mRNA CTD PMID:23649840 NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression
increases secretion
decreases response to substance
ISO Vincristine results in decreased expression of HMGB1 protein
Vincristine results in increased secretion of HMGB1 protein
HMGB1 protein results in decreased susceptibility to Vincristine
CTD PMID:27474498 PMID:27807322 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmgn5 high-mobility group nucleosome binding domain 5 decreases expression ISO Vincristine results in decreased expression of HMGN5 mRNA CTD PMID:23649840 NCBI chr  X:108,048,143...108,056,986
Ensembl chr  X:108,048,140...108,057,010
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
decreases activity
increases expression
ISO Vincristine results in decreased expression of HMOX1 mRNA
Vincristine results in decreased expression of HMOX1 protein
Quercetin inhibits the reaction [Vincristine results in decreased activity of HMOX1 protein]; Quercetin inhibits the reaction [Vincristine results in decreased expression of HMOX1 protein]
Vincristine results in increased expression of HMOX1 mRNA
CTD PMID:20624997 PMID:23649840 PMID:33038355 PMID:36808657 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Vincristine results in decreased expression of HNRNPA2B1 mRNA CTD PMID:23649840 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Vincristine results in decreased expression of HNRNPD mRNA CTD PMID:23649840 NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Vincristine results in decreased expression of HNRNPDL mRNA CTD PMID:23649840 NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523
JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R decreases expression ISO Vincristine results in decreased expression of HNRNPR mRNA CTD PMID:23649840 NCBI chr 4:136,038,230...136,086,758
Ensembl chr 4:136,038,253...136,086,758
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U decreases expression ISO Vincristine results in decreased expression of HNRNPU mRNA CTD PMID:23649840 NCBI chr 1:178,148,673...178,170,063
Ensembl chr 1:178,148,673...178,165,362
JBrowse link
G Hook1 hook microtubule tethering protein 1 decreases expression ISO Vincristine results in decreased expression of HOOK1 mRNA CTD PMID:23649840 NCBI chr 4:95,855,418...95,913,649
Ensembl chr 4:95,855,477...95,913,650
JBrowse link
G Hook3 hook microtubule tethering protein 3 decreases expression ISO Vincristine results in decreased expression of HOOK3 mRNA CTD PMID:23649840 NCBI chr 8:26,511,449...26,609,646
Ensembl chr 8:26,511,449...26,609,252
JBrowse link
G Hoxb7 homeobox B7 decreases expression ISO Vincristine results in decreased expression of HOXB7 mRNA CTD PMID:23649840 NCBI chr11:96,176,431...96,180,989
Ensembl chr11:96,177,449...96,180,988
JBrowse link
G Hpdl 4-hydroxyphenylpyruvate dioxygenase-like decreases expression ISO Vincristine results in decreased expression of HPDL mRNA CTD PMID:23649840 NCBI chr 4:116,677,104...116,678,705
Ensembl chr 4:116,677,101...116,678,904
JBrowse link
G Hras Harvey rat sarcoma virus oncogene increases expression ISO Vincristine results in increased expression of HRAS mRNA CTD PMID:16001973 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO Vincristine results in decreased expression of HS2ST1 mRNA CTD PMID:23649840 NCBI chr 3:144,135,462...144,275,977
Ensembl chr 3:144,135,467...144,275,942
JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions
ISO Vincristine results in increased expression of HSPA5 mRNA
Quercetin inhibits the reaction [Vincristine results in increased expression of HSPA5 mRNA]
CTD PMID:33038355 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspb2 heat shock protein 2 decreases response to substance ISO HSPB2 protein results in decreased susceptibility to Vincristine CTD PMID:17524270 NCBI chr 9:50,662,372...50,663,654
Ensembl chr 9:50,662,378...50,663,654
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) decreases expression ISO Vincristine results in decreased expression of HSPD1 mRNA CTD PMID:23649840 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A multiple interactions
increases expression
ISO [alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Vincristine
Vincristine results in increased expression of HTR2A protein
CTD PMID:18930597 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Hyls1 HYLS1, centriolar and ciliogenesis associated decreases expression ISO Vincristine results in decreased expression of HYLS1 mRNA CTD PMID:23649840 NCBI chr 9:35,472,117...35,481,365
Ensembl chr 9:35,472,116...35,481,694
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Vincristine results in increased expression of ICAM1 mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Icam4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group increases expression ISO Vincristine results in increased expression of ICAM4 mRNA CTD PMID:23649840 NCBI chr 9:20,940,728...20,941,892
Ensembl chr 9:20,940,669...20,941,891
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Vincristine results in increased expression of ID2 mRNA CTD PMID:23649840 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Id3 inhibitor of DNA binding 3 increases response to substance ISO ID3 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Vincristine results in increased expression of IER3 mRNA CTD PMID:23649840 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815
JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Vincristine results in increased expression of IFI44 mRNA CTD PMID:23649840 NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597
JBrowse link
G Ifi44l interferon-induced protein 44 like increases expression ISO Vincristine results in increased expression of IFI44L mRNA CTD PMID:23649840 NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression ISO Vincristine results in increased expression of IFIH1 mRNA CTD PMID:23649840 NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Vincristine results in increased expression of IFIT2 mRNA CTD PMID:23649840 NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819
JBrowse link
G Ifng interferon gamma increases expression ISO Vincristine results in increased expression of IFNG mRNA CTD PMID:23649840 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Vincristine results in decreased expression of IFRD1 mRNA CTD PMID:23649840 NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
JBrowse link
G Ift20 intraflagellar transport 20 increases expression ISO Vincristine results in increased expression of IFT20 mRNA CTD PMID:23649840 NCBI chr11:78,427,187...78,432,558
Ensembl chr11:78,427,187...78,432,563
JBrowse link
G Ift25 intraflagellar transport 25 decreases expression ISO Vincristine results in decreased expression of IFT25 mRNA CTD PMID:23649840 NCBI chr 4:107,110,889...107,137,135
Ensembl chr 4:107,110,790...107,137,135
JBrowse link
G Ift43 intraflagellar transport 43 increases expression ISO Vincristine results in increased expression of IFT43 mRNA CTD PMID:23649840 NCBI chr12:86,129,335...86,209,233
Ensembl chr12:86,129,315...86,209,233
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases response to substance
ISO
EXP
Vincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]
IGF1 protein results in decreased susceptibility to Vincristine
CTD PMID:9452187 PMID:16740780 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) decreases expression ISO Vincristine results in decreased expression of IGHG1 mRNA CTD PMID:23649840 NCBI chr12:113,290,161...113,294,143
Ensembl chr12:113,288,860...113,294,143
JBrowse link
G Ighm immunoglobulin heavy constant mu decreases expression ISO Vincristine results in decreased expression of IGHM mRNA CTD PMID:23649840 NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression ISO Vincristine results in decreased expression of IGKC mRNA CTD PMID:23649840 NCBI chr 6:70,703,419...70,703,738
Ensembl chr 6:70,703,419...70,703,950
JBrowse link
G Igkv8-27 immunoglobulin kappa chain variable 8-27 decreases expression ISO Vincristine results in decreased expression of IGKV4-1 mRNA CTD PMID:23649840 NCBI chr 6:70,148,793...70,149,254
Ensembl chr 6:70,148,793...70,149,254
JBrowse link
G Ikzf2 IKAROS family zinc finger 2 decreases expression ISO Vincristine results in decreased expression of IKZF2 mRNA CTD PMID:23649840 NCBI chr 1:69,570,382...69,726,510
Ensembl chr 1:69,570,373...69,726,404
JBrowse link
G Il10ra interleukin 10 receptor, alpha increases expression ISO Vincristine results in increased expression of IL10RA mRNA CTD PMID:23649840 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
JBrowse link
G Il15 interleukin 15 increases expression ISO Vincristine results in increased expression of IL15 mRNA CTD PMID:23649840 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il17rb interleukin 17 receptor B decreases expression ISO Vincristine results in decreased expression of IL17RB mRNA CTD PMID:23649840 NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
ISO
EXP
Vincristine results in increased expression of IL1B mRNA; Vincristine results in increased expression of IL1B protein
gap 27 peptide inhibits the reaction [Vincristine results in increased secretion of IL1B protein]; GJA1 protein promotes the reaction [Vincristine results in increased secretion of IL1B protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of IL1B mRNA]
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of IL1B mRNA]
CTD PMID:20624997 PMID:29958920 PMID:34286406 PMID:34939713 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r1 interleukin 1 receptor, type I increases expression ISO Vincristine results in increased expression of IL1R1 mRNA CTD PMID:23649840 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
JBrowse link
G Il2 interleukin 2 multiple interactions
increases expression
ISO tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il23a interleukin 23, alpha subunit p19 increases expression ISO Vincristine results in increased expression of IL23A mRNA CTD PMID:23649840 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il36g interleukin 36G increases expression ISO Vincristine results in increased expression of IL36G mRNA CTD PMID:23649840 NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580
JBrowse link
G Il6 interleukin 6 affects response to substance
increases secretion
multiple interactions
increases expression
ISO
EXP
IL6 protein affects the susceptibility to Vincristine
Vincristine results in increased secretion of IL6 protein
gap 27 peptide inhibits the reaction [Vincristine results in increased secretion of IL6 protein]; GJA1 protein promotes the reaction [Vincristine results in increased secretion of IL6 protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of IL6 mRNA]
Vincristine results in increased expression of IL6 mRNA; Vincristine results in increased expression of IL6 protein
CTD PMID:16001973 PMID:18270703 PMID:18652822 PMID:23649840 PMID:34286406 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il7 interleukin 7 increases expression ISO Vincristine results in increased expression of IL7 mRNA CTD PMID:23649840 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Ildr1 immunoglobulin-like domain containing receptor 1 increases expression ISO Vincristine results in increased expression of ILDR1 mRNA CTD PMID:23649840 NCBI chr16:36,514,340...36,547,166
Ensembl chr16:36,514,340...36,547,166
JBrowse link
G Ildr2 immunoglobulin-like domain containing receptor 2 decreases expression ISO Vincristine results in decreased expression of ILDR2 mRNA CTD PMID:23649840 NCBI chr 1:166,081,630...166,144,405
Ensembl chr 1:166,081,708...166,144,392
JBrowse link
G Impa2 inositol monophosphatase 2 decreases expression ISO Vincristine results in decreased expression of IMPA2 mRNA CTD PMID:23649840 NCBI chr18:67,422,246...67,454,375
Ensembl chr18:67,422,256...67,455,542
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr19:47,003,120...47,013,766
Ensembl chr19:47,003,137...47,013,766
JBrowse link
G Ing2 inhibitor of growth family, member 2 decreases expression ISO Vincristine results in decreased expression of ING2 mRNA CTD PMID:23649840 NCBI chr 8:48,120,213...48,128,627
Ensembl chr 8:48,120,213...48,128,591
JBrowse link
G Inha inhibin alpha decreases expression ISO Vincristine results in decreased expression of INHA mRNA CTD PMID:20624997 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010
JBrowse link
G Inhbe inhibin beta-E increases expression ISO Vincristine results in increased expression of INHBE mRNA CTD PMID:23649840 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
JBrowse link
G Inpp1 inositol polyphosphate-1-phosphatase increases expression ISO Vincristine results in increased expression of INPP1 mRNA CTD PMID:23649840 NCBI chr 1:52,824,584...52,856,847
Ensembl chr 1:52,824,586...52,856,847
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase, type II increases expression ISO Vincristine results in increased expression of INPP4B mRNA CTD PMID:23649840 NCBI chr 8:82,068,895...82,865,553
Ensembl chr 8:82,069,185...82,854,543
JBrowse link
G Ints11 integrator complex subunit 11 decreases expression ISO Vincristine results in decreased expression of INTS11 mRNA CTD PMID:23649840 NCBI chr 4:155,954,006...155,973,561
Ensembl chr 4:155,954,003...155,973,560
JBrowse link
G Ints5 integrator complex subunit 5 decreases expression ISO Vincristine results in decreased expression of INTS5 mRNA CTD PMID:23649840 NCBI chr19:8,870,351...8,875,254
Ensembl chr19:8,870,369...8,875,252
JBrowse link
G Ipo5 importin 5 decreases expression ISO Vincristine results in decreased expression of IPO5 mRNA CTD PMID:23649840 NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 decreases expression ISO Vincristine results in decreased expression of IQGAP2 mRNA CTD PMID:23649840 NCBI chr13:95,763,685...96,028,788
Ensembl chr13:95,763,682...96,028,991
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO Vincristine results in increased expression of IRAK2 mRNA CTD PMID:23649840 NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987
JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression ISO Vincristine results in increased expression of IREB2 mRNA CTD PMID:23649840 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO Vincristine results in increased expression of IRF1 mRNA CTD PMID:23649840 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200
JBrowse link
G Isg20 interferon-stimulated protein increases expression ISO Vincristine results in increased expression of ISG20 mRNA CTD PMID:23649840 NCBI chr 7:78,561,136...78,570,144
Ensembl chr 7:78,563,172...78,570,144
JBrowse link
G Islr immunoglobulin superfamily containing leucine-rich repeat increases expression ISO Vincristine results in increased expression of ISLR mRNA CTD PMID:23649840 NCBI chr 9:58,063,547...58,066,563
Ensembl chr 9:58,063,551...58,111,589
JBrowse link
G Itga1 integrin alpha 1 increases response to substance ISO ITGA1 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500
JBrowse link
G Itga4 integrin alpha 4 decreases expression ISO Vincristine results in decreased expression of ITGA4 mRNA CTD PMID:23649840 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467
JBrowse link
G Itgam integrin alpha M increases expression ISO Vincristine results in increased expression of ITGAM mRNA CTD PMID:23649840 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb1bp2 integrin beta 1 binding protein 2 decreases expression ISO Vincristine results in decreased expression of ITGB1BP2 mRNA CTD PMID:23649840 NCBI chr  X:100,492,694...100,520,391
Ensembl chr  X:100,492,694...100,497,147
JBrowse link
G Itgb7 integrin beta 7 decreases expression ISO Vincristine results in decreased expression of ITGB7 mRNA CTD PMID:23649840 NCBI chr15:102,124,429...102,141,840
Ensembl chr15:102,124,430...102,140,379
JBrowse link
G Itgb8 integrin beta 8 increases expression ISO Vincristine results in increased expression of ITGB8 mRNA CTD PMID:23649840 NCBI chr12:119,121,757...119,202,891
Ensembl chr12:119,121,757...119,202,537
JBrowse link
G Itpkb inositol 1,4,5-trisphosphate 3-kinase B decreases expression ISO Vincristine results in decreased expression of ITPKB mRNA CTD PMID:23649840 NCBI chr 1:180,156,655...180,252,367
Ensembl chr 1:180,158,050...180,252,367
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 increases expression ISO Vincristine results in increased expression of ITPR1 mRNA CTD PMID:23649840 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
JBrowse link
G Itprid2 ITPR interacting domain containing 2 decreases expression ISO Vincristine results in decreased expression of ITPRID2 mRNA CTD PMID:23649840 NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310
JBrowse link
G Itpripl1 inositol 1,4,5-triphosphate receptor interacting protein-like 1 decreases expression ISO Vincristine results in decreased expression of ITPRIPL1 mRNA CTD PMID:23649840 NCBI chr 2:126,980,689...126,985,377
Ensembl chr 2:126,980,692...126,985,362
JBrowse link
G Ivl involucrin increases expression ISO Vincristine results in increased expression of IVL mRNA CTD PMID:23649840 NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042
JBrowse link
G Ivns1abp influenza virus NS1A binding protein decreases expression ISO Vincristine results in decreased expression of IVNS1ABP mRNA CTD PMID:23649840 NCBI chr 1:151,220,237...151,240,196
Ensembl chr 1:151,220,228...151,240,173
JBrowse link
G Jade2 jade family PHD finger 2 increases expression ISO Vincristine results in increased expression of JADE2 mRNA CTD PMID:23649840 NCBI chr11:51,704,278...51,749,835
Ensembl chr11:51,704,282...51,748,480
JBrowse link
G Jchain immunoglobulin joining chain decreases expression ISO Vincristine results in decreased expression of JCHAIN mRNA CTD PMID:23649840 NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750
JBrowse link
G Jmjd1c jumonji domain containing 1C increases expression ISO Vincristine results in increased expression of JMJD1C mRNA CTD PMID:23649840 NCBI chr10:66,932,189...67,092,105
Ensembl chr10:66,931,904...67,092,105
JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 decreases expression ISO Vincristine results in decreased expression of JPT1 mRNA CTD PMID:23649840 NCBI chr11:115,388,171...115,405,219
Ensembl chr11:115,388,179...115,405,213
JBrowse link
G Jun jun proto-oncogene increases expression ISO Vincristine results in increased expression of JUN mRNA CTD PMID:23649840 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kat2b K(lysine) acetyltransferase 2B increases expression ISO Vincristine results in increased expression of KAT2B mRNA CTD PMID:16001973 NCBI chr17:53,873,802...53,979,749
Ensembl chr17:53,873,889...53,979,748
JBrowse link
G Kcmf1 potassium channel modulatory factor 1 decreases expression ISO Vincristine results in decreased expression of KCMF1 mRNA CTD PMID:23649840 NCBI chr 6:72,818,097...72,876,962
Ensembl chr 6:72,818,097...72,876,962
JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 increases response to substance ISO KCNA5 protein results in increased susceptibility to Vincristine CTD PMID:17428690 NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375
JBrowse link
G Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 increases expression ISO Vincristine results in increased expression of KCNMB1 mRNA CTD PMID:23649840 NCBI chr11:33,912,955...33,923,641
Ensembl chr11:33,913,013...33,923,641
JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 increases expression ISO Vincristine results in increased expression of KCNN2 mRNA CTD PMID:23649840 NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
JBrowse link
G Kdm2b lysine (K)-specific demethylase 2B increases expression ISO Vincristine results in increased expression of KDM2B mRNA CTD PMID:23649840 NCBI chr 5:123,008,727...123,127,333
Ensembl chr 5:123,008,728...123,127,886
JBrowse link
G Kdsr 3-ketodihydrosphingosine reductase decreases expression ISO Vincristine results in decreased expression of KDSR mRNA CTD PMID:23649840 NCBI chr 1:106,648,140...106,689,544
Ensembl chr 1:106,648,189...106,687,457
JBrowse link
G Klf12 Kruppel-like transcription factor 12 decreases expression ISO Vincristine results in decreased expression of KLF12 mRNA CTD PMID:23649840 NCBI chr14:100,103,617...100,719,681
Ensembl chr14:100,108,068...100,522,115
JBrowse link
G Klf6 Kruppel-like transcription factor 6 increases expression ISO Vincristine results in increased expression of KLF6 mRNA CTD PMID:23649840 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393
JBrowse link
G Klhl14 kelch-like 14 decreases expression ISO Vincristine results in decreased expression of KLHL14 mRNA CTD PMID:23649840 NCBI chr18:21,683,436...21,805,986
Ensembl chr18:21,683,434...21,787,775
JBrowse link
G Klhl28 kelch-like 28 increases expression ISO Vincristine results in increased expression of KLHL28 mRNA CTD PMID:23649840 NCBI chr12:64,985,603...65,012,365
Ensembl chr12:64,985,607...65,012,308
JBrowse link
G Kmt5b lysine methyltransferase 5B increases expression ISO Vincristine results in increased expression of KMT5B mRNA CTD PMID:23649840 NCBI chr19:3,816,436...3,868,303
Ensembl chr19:3,817,421...3,868,303
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO Vincristine results in decreased expression of KPNA2 mRNA CTD PMID:23649840 NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367
JBrowse link
G Krt23 keratin 23 increases response to substance ISO KRT23 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr11:99,368,799...99,383,946
Ensembl chr11:99,368,800...99,383,963
JBrowse link
G Krt7 keratin 7 increases expression ISO Vincristine results in increased expression of KRT7 mRNA CTD PMID:23649840 NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194
JBrowse link
G Kynu kynureninase increases expression ISO Vincristine results in increased expression of KYNU mRNA CTD PMID:23649840 NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734
JBrowse link
G Lactb2 lactamase, beta 2 decreases expression ISO Vincristine results in decreased expression of LACTB2 mRNA CTD PMID:23649840 NCBI chr 1:13,695,069...13,730,749
Ensembl chr 1:13,693,554...13,730,770
JBrowse link
G Lama2 laminin, alpha 2 increases response to substance ISO LAMA2 mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr10:26,857,281...27,493,021
Ensembl chr10:26,856,032...27,495,754
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 increases expression ISO Vincristine results in increased expression of LAMP3 mRNA CTD PMID:23649840 NCBI chr16:19,472,131...19,525,115
Ensembl chr16:19,472,128...19,525,125
JBrowse link
G Larp1b La ribonucleoprotein 1B decreases expression ISO Vincristine results in decreased expression of LARP1B mRNA CTD PMID:23649840 NCBI chr 3:40,904,198...40,994,642
Ensembl chr 3:40,904,263...40,994,669
JBrowse link
G Lbh limb-bud and heart decreases expression ISO Vincristine results in decreased expression of LBH mRNA CTD PMID:23649840 NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO Vincristine results in increased expression of LCE1B mRNA CTD PMID:23649840 NCBI chr 3:92,562,957...92,564,233
Ensembl chr 3:92,562,957...92,564,233
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor increases expression ISO Vincristine results in increased expression of LCOR mRNA CTD PMID:23649840 NCBI chr19:41,471,121...41,584,600
Ensembl chr19:41,471,076...41,574,975
JBrowse link
G Lcorl ligand dependent nuclear receptor corepressor-like decreases expression ISO Vincristine results in decreased expression of LCORL mRNA CTD PMID:23649840 NCBI chr 5:45,854,523...46,015,213
NCBI chr 5:45,877,009...45,884,920
Ensembl chr 5:45,854,523...46,014,957
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Vincristine results in increased expression of LCP2 mRNA CTD PMID:23649840 NCBI chr11:33,996,928...34,042,281
Ensembl chr11:33,996,920...34,042,295
JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 increases expression ISO Vincristine results in increased expression of LDLRAD4 mRNA CTD PMID:23649840 NCBI chr18:68,065,345...68,393,621
Ensembl chr18:68,066,328...68,401,701
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 decreases expression ISO Vincristine results in decreased expression of LDLRAP1 mRNA CTD PMID:23649840 NCBI chr 4:134,468,865...134,495,342
Ensembl chr 4:134,468,865...134,495,335
JBrowse link
G Leng8 leukocyte receptor cluster (LRC) member 8 decreases expression ISO Vincristine results in decreased expression of LENG8 mRNA CTD PMID:23649840 NCBI chr 7:4,140,014...4,151,176
Ensembl chr 7:4,140,038...4,151,176
JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Vincristine results in increased expression of LIF mRNA CTD PMID:23649840 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO Vincristine results in increased expression of LIMA1 mRNA CTD PMID:23649840 NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337
JBrowse link
G Lims1 LIM and senescent cell antigen-like domains 1 increases expression ISO Vincristine results in increased expression of LIMS1 mRNA CTD PMID:23649840 NCBI chr10:58,159,164...58,260,513
Ensembl chr10:58,159,288...58,260,513
JBrowse link
G Lmna lamin A increases expression ISO Vincristine results in increased expression of LMNA mRNA CTD PMID:23649840 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Lnpep leucyl/cystinyl aminopeptidase increases expression ISO Vincristine results in increased expression of LNPEP mRNA CTD PMID:23649840 NCBI chr17:17,747,985...17,846,303
Ensembl chr17:17,741,672...17,845,312
JBrowse link
G Lrba LPS-responsive beige-like anchor decreases expression ISO Vincristine results in decreased expression of LRBA mRNA CTD PMID:23649840 NCBI chr 3:86,130,763...86,690,001
Ensembl chr 3:86,131,987...86,689,999
JBrowse link
G Lrch3 leucine-rich repeats and calponin homology (CH) domain containing 3 increases expression ISO Vincristine results in increased expression of LRCH3 mRNA CTD PMID:23649840 NCBI chr16:32,734,452...32,836,399
Ensembl chr16:32,734,470...32,836,017
JBrowse link
G Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor decreases expression ISO Vincristine results in decreased expression of LRP8 mRNA CTD PMID:23649840 NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037
JBrowse link
G Lrrc8c leucine rich repeat containing 8 family, member C decreases expression ISO Vincristine results in decreased expression of LRRC8C mRNA CTD PMID:23649840 NCBI chr 5:105,666,850...105,760,884
Ensembl chr 5:105,667,254...105,760,884
JBrowse link
G Lrrcc1 leucine rich repeat and coiled-coil domain containing 1 decreases expression ISO Vincristine results in decreased expression of LRRCC1 mRNA CTD PMID:23649840 NCBI chr 3:14,595,512...14,637,718
Ensembl chr 3:14,598,848...14,637,718
JBrowse link
G Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 decreases expression ISO Vincristine results in decreased expression of LRRFIP1 mRNA CTD PMID:23649840 NCBI chr 1:90,924,652...91,056,666
Ensembl chr 1:90,926,459...91,056,666
JBrowse link
G Lta lymphotoxin A increases expression ISO Vincristine results in increased expression of LTA mRNA CTD PMID:23649840 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G LTO1 ABCE maturation factor decreases expression ISO Vincristine results in decreased expression of LTO1 mRNA CTD PMID:23649840 NCBI chr 7:144,468,882...144,485,989
Ensembl chr 7:144,468,837...144,485,438
JBrowse link
G Lum lumican decreases response to substance ISO LUM mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
JBrowse link
G Ly96 lymphocyte antigen 96 increases expression ISO Vincristine results in increased expression of LY96 mRNA CTD PMID:23649840 NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835
JBrowse link
G Lztfl1 leucine zipper transcription factor-like 1 decreases expression ISO Vincristine results in decreased expression of LZTFL1 mRNA CTD PMID:23649840 NCBI chr 9:123,523,469...123,546,690
Ensembl chr 9:123,523,481...123,546,762
JBrowse link
G Lzts2 leucine zipper, putative tumor suppressor 2 decreases expression ISO Vincristine results in decreased expression of LZTS2 mRNA CTD PMID:23649840 NCBI chr19:45,003,615...45,015,554
Ensembl chr19:45,002,853...45,015,550
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 increases expression ISO Vincristine results in increased expression of MACF1 mRNA CTD PMID:23649840 NCBI chr 4:123,243,386...123,581,594
Ensembl chr 4:123,243,426...123,581,331
JBrowse link
G Macir macrophage immunometabolism regulator decreases expression ISO Vincristine results in decreased expression of MACIR mRNA CTD PMID:23649840 NCBI chr 1:97,571,627...97,589,743
Ensembl chr 1:97,534,043...97,589,799
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Vincristine results in increased expression of MAFF mRNA CTD PMID:23649840 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
JBrowse link
G Magt1 magnesium transporter 1 decreases expression ISO Vincristine results in decreased expression of MAGT1 mRNA CTD PMID:23649840 NCBI chr  X:105,011,690...105,055,408
Ensembl chr  X:105,011,690...105,055,512
JBrowse link
G Man2a1 mannosidase 2, alpha 1 decreases expression ISO Vincristine results in decreased expression of MAN2A1 mRNA CTD PMID:23649840 NCBI chr17:64,907,683...65,062,105
Ensembl chr17:64,907,731...65,062,105
JBrowse link
G Manea mannosidase, endo-alpha decreases expression ISO Vincristine results in decreased expression of MANEA mRNA CTD PMID:23649840 NCBI chr 4:26,324,506...26,346,913
Ensembl chr 4:26,324,506...26,346,891
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO Vincristine results in increased expression of MAP1LC3B mRNA
Vincristine results in increased expression of MAP1LC3B protein
Quercetin inhibits the reaction [Vincristine results in increased expression of MAP1LC3B protein]
CTD PMID:23649840 PMID:36808657 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Vincristine results in decreased expression of MAP3K1 mRNA CTD PMID:23649840 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527
JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 decreases expression ISO Vincristine results in decreased expression of MAP3K7 mRNA CTD PMID:23649840 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO Vincristine results in increased expression of MAP3K8 mRNA CTD PMID:23649840 NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 increases expression ISO Vincristine results in increased expression of MAP4K4 mRNA CTD PMID:23649840 NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470
JBrowse link
G Mapkbp1 mitogen-activated protein kinase binding protein 1 increases expression ISO Vincristine results in increased expression of MAPKBP1 mRNA CTD PMID:23649840 NCBI chr 2:119,802,868...119,857,884
Ensembl chr 2:119,803,180...119,857,889
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 decreases localization
multiple interactions
ISO Vincristine results in decreased localization of MAPRE1 protein
olesoxime inhibits the reaction [Vincristine results in decreased localization of MAPRE1 protein]
CTD PMID:20417191 NCBI chr 2:153,583,131...153,615,237
Ensembl chr 2:153,583,194...153,615,230
JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 multiple interactions
affects localization
ISO olesoxime inhibits the reaction [Vincristine results in decreased localization of MAPRE3 protein]
Vincristine affects the localization of MAPRE3 protein
CTD PMID:20417191 NCBI chr 5:30,972,075...31,023,447
Ensembl chr 5:30,971,985...31,023,450
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 increases expression ISO Vincristine results in increased expression of MARCHF7 mRNA CTD PMID:23649840 NCBI chr 2:60,040,086...60,079,555
Ensembl chr 2:60,040,231...60,081,020
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression ISO Vincristine results in increased expression of MARCKS mRNA CTD PMID:23649840 NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916
JBrowse link
G Mars1 methionine-tRNA synthetase 1 decreases expression ISO Vincristine results in decreased expression of MARS1 mRNA CTD PMID:23649840 NCBI chr10:127,132,090...127,147,655
Ensembl chr10:127,132,090...127,147,655
JBrowse link
G Mars2 methionine-tRNA synthetase 2 (mitochondrial) decreases expression ISO Vincristine results in decreased expression of MARS2 mRNA CTD PMID:23649840 NCBI chr 1:55,276,336...55,279,217
Ensembl chr 1:55,276,336...55,287,629
JBrowse link
G Matn2 matrilin 2 decreases response to substance ISO MATN2 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr15:34,306,827...34,436,388
Ensembl chr15:34,306,823...34,436,419
JBrowse link
G Matr3 matrin 3 decreases expression ISO Vincristine results in decreased expression of MATR3 mRNA CTD PMID:23649840 NCBI chr18:35,686,462...35,724,526
Ensembl chr18:35,695,191...35,726,888
JBrowse link
G Max Max protein decreases expression ISO Vincristine results in decreased expression of MAX mRNA CTD PMID:23649840 NCBI chr12:76,984,045...77,009,123
Ensembl chr12:76,984,043...77,008,975
JBrowse link
G Mbd4 methyl-CpG binding domain protein 4 decreases expression ISO Vincristine results in decreased expression of MBD4 mRNA CTD PMID:23649840 NCBI chr 6:115,817,658...115,830,361
Ensembl chr 6:115,817,658...115,830,332
JBrowse link
G Mbnl3 muscleblind like splicing factor 3 decreases expression ISO Vincristine results in decreased expression of MBNL3 mRNA CTD PMID:23649840 NCBI chr  X:50,202,371...50,294,867
Ensembl chr  X:50,206,146...50,295,409
JBrowse link
G Mbtd1 mbt domain containing 1 increases expression ISO Vincristine results in increased expression of MBTD1 mRNA CTD PMID:23649840 NCBI chr11:93,776,635...93,837,815
Ensembl chr11:93,776,678...93,837,811
JBrowse link
G Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) increases expression ISO Vincristine results in increased expression of MCCC2 mRNA CTD PMID:23649840 NCBI chr13:100,085,040...100,152,147
Ensembl chr13:100,085,038...100,152,147
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 increases expression ISO Vincristine results in increased expression of MCL1 mRNA CTD PMID:23649840 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Vincristine results in decreased expression of MCM4 mRNA CTD PMID:23649840 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mcmbp minichromosome maintenance complex binding protein increases expression ISO Vincristine results in increased expression of MCMBP mRNA CTD PMID:23649840 NCBI chr 7:128,298,165...128,342,153
Ensembl chr 7:128,298,165...128,342,219
JBrowse link
G Mcoln2 mucolipin 2 increases expression ISO Vincristine results in increased expression of MCOLN2 mRNA CTD PMID:23649840 NCBI chr 3:145,855,552...145,901,269
Ensembl chr 3:145,855,588...145,901,268
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression
decreases expression
ISO Vincristine results in increased expression of MDM2 mRNA
Vincristine results in decreased expression of MDM2 mRNA
CTD PMID:16001973 PMID:23649840 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mdn1 midasin AAA ATPase 1 increases expression ISO Vincristine results in increased expression of MDN1 mRNA CTD PMID:23649840 NCBI chr 4:32,656,867...32,775,217
Ensembl chr 4:32,657,119...32,775,217
JBrowse link
G Med29 mediator complex subunit 29 decreases expression ISO Vincristine results in decreased expression of MED29 mRNA CTD PMID:23649840 NCBI chr 7:28,084,667...28,092,126
Ensembl chr 7:28,085,571...28,092,133
JBrowse link
G Med31 mediator complex subunit 31 decreases expression ISO Vincristine results in decreased expression of MED31 mRNA CTD PMID:23649840 NCBI chr11:72,102,550...72,106,418
Ensembl chr11:72,102,550...72,106,418
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Vincristine results in decreased expression of METTL3 mRNA CTD PMID:23649840 NCBI chr14:52,532,298...52,548,555
Ensembl chr14:52,532,298...52,542,585
JBrowse link
G Mfsd5 major facilitator superfamily domain containing 5 decreases expression ISO Vincristine results in decreased expression of MFSD5 mRNA CTD PMID:23649840 NCBI chr15:102,187,891...102,190,179
Ensembl chr15:102,187,889...102,190,189
JBrowse link
G Mfsd6 major facilitator superfamily domain containing 6 decreases expression ISO Vincristine results in decreased expression of MFSD6 mRNA CTD PMID:23649840 NCBI chr 1:52,695,463...52,766,495
Ensembl chr 1:52,695,445...52,766,621
JBrowse link
G Mga MAX gene associated increases expression ISO Vincristine results in increased expression of MGA mRNA CTD PMID:23649840 NCBI chr 2:119,702,974...119,800,610
Ensembl chr 2:119,727,709...119,800,062
JBrowse link
G Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A decreases expression ISO Vincristine results in decreased expression of MGAT4A mRNA CTD PMID:23649840 NCBI chr 1:37,478,421...37,580,599
Ensembl chr 1:37,478,421...37,580,097
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine; MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:11792417 PMID:16033832 PMID:16936459 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
JBrowse link
G Mical3 microtubule associated monooxygenase, calponin and LIM domain containing 3 increases expression ISO Vincristine results in increased expression of MICAL3 mRNA CTD PMID:23649840 NCBI chr 6:120,908,507...121,150,716
Ensembl chr 6:120,908,668...121,107,959
JBrowse link
G Mir132 microRNA 132 increases expression ISO Vincristine results in increased expression of MIR132 mRNA CTD PMID:32505695 NCBI chr11:75,064,508...75,064,573
Ensembl chr11:75,064,508...75,064,573
JBrowse link
G Mir497 microRNA 497 multiple interactions ISO [MIR497 results in decreased expression of BCL2 protein] which results in increased susceptibility to Vincristine CTD PMID:21258880 NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases response to substance ISO MKI67 gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mkln1 muskelin 1, intracellular mediator containing kelch motifs increases expression ISO Vincristine results in increased expression of MKLN1 mRNA CTD PMID:23649840 NCBI chr 6:31,333,833...31,493,744
Ensembl chr 6:31,375,670...31,493,746
JBrowse link
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 increases expression ISO Vincristine results in increased expression of MKNK2 mRNA CTD PMID:23649840 NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
JBrowse link
G Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 increases expression ISO Vincristine results in increased expression of MLLT3 mRNA CTD PMID:23649840 NCBI chr 4:87,688,162...87,951,652
Ensembl chr 4:87,688,162...87,951,601
JBrowse link
G Mmd monocyte to macrophage differentiation-associated increases expression ISO Vincristine results in increased expression of MMD mRNA CTD PMID:23649840 NCBI chr11:90,078,513...90,169,399
Ensembl chr11:90,140,282...90,169,415
JBrowse link
G Mnd1 meiotic nuclear divisions 1 decreases expression ISO Vincristine results in decreased expression of MND1 mRNA CTD PMID:23649840 NCBI chr 3:83,995,240...84,063,084
Ensembl chr 3:83,995,240...84,063,093
JBrowse link
G Mpz myelin protein zero increases response to substance EXP MPZ gene results in increased susceptibility to Vincristine CTD PMID:16676325 NCBI chr 1:170,978,282...170,988,699
Ensembl chr 1:170,978,280...170,988,699
JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression ISO Vincristine results in increased expression of MR1 mRNA CTD PMID:23649840 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560
JBrowse link
G Mrpl30 mitochondrial ribosomal protein L30 decreases expression ISO Vincristine results in decreased expression of MRPL30 mRNA CTD PMID:23649840 NCBI chr 1:37,929,558...37,937,419
Ensembl chr 1:37,929,558...37,937,616
JBrowse link
G Mrpl39 mitochondrial ribosomal protein L39 decreases expression ISO Vincristine results in decreased expression of MRPL39 mRNA CTD PMID:23649840 NCBI chr16:84,515,068...84,532,261
Ensembl chr16:84,514,464...84,532,630
JBrowse link
G Mrpl50 mitochondrial ribosomal protein L50 decreases expression ISO Vincristine results in decreased expression of MRPL50 mRNA CTD PMID:23649840 NCBI chr 4:49,512,597...49,521,083
Ensembl chr 4:49,512,596...49,521,093
JBrowse link
G Mrps16 mitochondrial ribosomal protein S16 decreases expression ISO Vincristine results in decreased expression of MRPS16 mRNA CTD PMID:23649840 NCBI chr14:20,441,290...20,443,702
Ensembl chr14:20,439,372...20,443,702
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial increases expression ISO Vincristine results in increased expression of ND6 mRNA CTD PMID:23649840 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Vincristine results in increased expression of MT1X mRNA CTD PMID:23649840 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Mt2 metallothionein 2 increases expression ISO Vincristine results in increased expression of MT2A mRNA CTD PMID:23649840 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mta3 metastasis associated 3 decreases expression ISO Vincristine results in decreased expression of MTA3 mRNA CTD PMID:23649840 NCBI chr17:84,013,483...84,131,144
Ensembl chr17:84,013,592...84,128,945
JBrowse link
G Mtcp1 mature T cell proliferation 1 decreases expression ISO Vincristine results in decreased expression of MTCP1 mRNA CTD PMID:23649840 NCBI chr  X:74,454,048...74,460,190
Ensembl chr  X:74,454,050...74,460,194
JBrowse link
G Mtfr2 mitochondrial fission regulator 2 decreases expression ISO Vincristine results in decreased expression of MTFR2 mRNA CTD PMID:23649840 NCBI chr10:20,223,491...20,237,415
Ensembl chr10:20,223,516...20,237,050
JBrowse link
G Mtg2 mitochondrial ribosome associated GTPase 2 increases expression ISO Vincristine results in increased expression of MTG2 mRNA CTD PMID:23649840 NCBI chr 2:179,712,366...179,727,695
Ensembl chr 2:179,712,381...179,727,695
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like decreases expression ISO Vincristine results in decreased expression of MTHFD2L mRNA CTD PMID:23649840 NCBI chr 5:91,078,704...91,169,227
Ensembl chr 5:91,078,976...91,169,227
JBrowse link
G Mtrf1l mitochondrial translational release factor 1-like decreases expression ISO Vincristine results in decreased expression of MTRF1L mRNA CTD PMID:23649840 NCBI chr10:5,760,151...5,775,015
Ensembl chr10:5,761,887...5,773,910
JBrowse link
G Mvp major vault protein increases expression ISO Vincristine results in increased expression of MVP mRNA CTD PMID:23649840 NCBI chr 7:126,586,036...126,613,729
Ensembl chr 7:126,586,032...126,613,793
JBrowse link
G Mxd1 MAX dimerization protein 1 increases expression ISO Vincristine results in increased expression of MXD1 mRNA CTD PMID:23649840 NCBI chr 6:86,624,026...86,646,099
Ensembl chr 6:86,624,024...86,646,143
JBrowse link
G Myc myelocytomatosis oncogene decreases expression
increases expression
ISO Vincristine results in decreased expression of MYC mRNA
Vincristine results in increased expression of MYC mRNA
CTD PMID:16001973 PMID:20624997 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived decreases response to substance
multiple interactions
ISO MYCN protein results in decreased susceptibility to Vincristine
[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Vincristine
CTD PMID:10348353 NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
JBrowse link
G Myh11 myosin, heavy polypeptide 11, smooth muscle increases expression ISO Vincristine results in increased expression of MYH11 mRNA CTD PMID:23649840 NCBI chr16:14,012,392...14,109,227
Ensembl chr16:14,012,399...14,109,236
JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 increases expression ISO Vincristine results in increased expression of MYSM1 mRNA CTD PMID:23649840 NCBI chr 4:94,830,274...94,867,392
Ensembl chr 4:94,830,277...94,867,337
JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein 1 decreases expression ISO Vincristine results in decreased expression of MZB1 mRNA CTD PMID:23649840 NCBI chr18:35,780,318...35,782,420
Ensembl chr18:35,780,320...35,782,420
JBrowse link
G N4bp2l2 NEDD4 binding protein 2-like 2 increases expression ISO Vincristine results in increased expression of N4BP2L2 mRNA CTD PMID:23649840 NCBI chr 5:150,515,310...150,589,213
Ensembl chr 5:150,531,472...150,589,648
JBrowse link
G Naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit decreases expression ISO Vincristine results in decreased expression of NAA25 mRNA CTD PMID:23649840 NCBI chr 5:121,535,977...121,580,612
Ensembl chr 5:121,535,999...121,582,441
JBrowse link
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit decreases expression ISO Vincristine results in decreased expression of NAA50 mRNA CTD PMID:23649840 NCBI chr16:43,960,154...43,983,825
Ensembl chr16:43,960,193...43,983,729
JBrowse link
G Nabp1 nucleic acid binding protein 1 increases expression ISO Vincristine results in increased expression of NABP1 mRNA CTD PMID:23649840 NCBI chr 1:51,504,127...51,517,634
Ensembl chr 1:51,505,021...51,517,584
JBrowse link
G Naca nascent polypeptide-associated complex alpha polypeptide decreases expression ISO Vincristine results in decreased expression of NACA mRNA CTD PMID:23649840 NCBI chr10:127,869,144...127,884,506
Ensembl chr10:127,871,444...127,884,506
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Vincristine results in increased expression of NAMPT mRNA CTD PMID:23649840 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348
JBrowse link
G Napb N-ethylmaleimide sensitive fusion protein attachment protein beta increases expression ISO Vincristine results in increased expression of NAPB mRNA CTD PMID:23649840 NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387
JBrowse link
G Nasp nuclear autoantigenic sperm protein (histone-binding) decreases expression ISO Vincristine results in decreased expression of NASP mRNA CTD PMID:23649840 NCBI chr 4:116,458,249...116,488,894
Ensembl chr 4:116,458,249...116,485,138
JBrowse link
G Nbn nibrin increases expression ISO Vincristine results in increased expression of NBN mRNA CTD PMID:20624997 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 decreases expression ISO Vincristine results in decreased expression of NCBP1 mRNA CTD PMID:23649840 NCBI chr 4:46,138,732...46,172,403
Ensembl chr 4:46,138,613...46,172,403
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 increases expression ISO Vincristine results in increased expression of NCEH1 mRNA CTD PMID:23649840 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO Vincristine results in increased expression of NCF2 mRNA CTD PMID:23649840 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Ncoa7 nuclear receptor coactivator 7 increases expression ISO Vincristine results in increased expression of NCOA7 mRNA CTD PMID:23649840 NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322
JBrowse link
G Nde1 nudE neurodevelopment protein 1 increases expression ISO Vincristine results in increased expression of NDE1 mRNA CTD PMID:23649840 NCBI chr16:13,981,139...14,010,792
Ensembl chr16:13,981,139...14,010,792
JBrowse link
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 decreases expression ISO Vincristine results in decreased expression of NDUFB4 mRNA CTD PMID:23649840 NCBI chr16:37,467,962...37,474,779
Ensembl chr16:37,467,532...37,474,815
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions
increases expression
ISO coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein] CTD PMID:34939713 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Neurl3 neuralized E3 ubiquitin protein ligase 3 increases expression ISO Vincristine results in increased expression of NEURL3 mRNA CTD PMID:23649840 NCBI chr 1:36,303,683...36,313,755
Ensembl chr 1:36,303,678...36,313,760
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 increases expression ISO Vincristine results in increased expression of NFAT5 mRNA CTD PMID:23649840 NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149
JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 increases response to substance ISO NFATC2 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577
JBrowse link
G Nfe2l1 nuclear factor, erythroid derived 2,-like 1 increases expression ISO Vincristine results in increased expression of NFE2L1 mRNA CTD PMID:23649840 NCBI chr11:96,708,239...96,720,810
Ensembl chr11:96,708,240...96,720,794
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression
multiple interactions
ISO Vincristine results in decreased expression of NFE2L2 mRNA; Vincristine results in decreased expression of NFE2L2 protein
coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]; Quercetin inhibits the reaction [Vincristine results in decreased expression of NFE2L2 protein]
CTD PMID:33038355 PMID:34939713 PMID:36808657 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfe2l3 nuclear factor, erythroid derived 2, like 3 decreases expression ISO Vincristine results in decreased expression of NFE2L3 mRNA CTD PMID:23649840 NCBI chr 6:51,409,649...51,435,752
Ensembl chr 6:51,409,650...51,435,748
JBrowse link
G Ngf nerve growth factor multiple interactions
decreases response to substance
ISO Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]; Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]
NGF protein results in decreased susceptibility to Vincristine; Vincristine results in decreased susceptibility to NGF protein
CTD PMID:9524088 PMID:9622663 PMID:10553948 PMID:11991087 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nhsl1 NHS like 1 increases expression ISO Vincristine results in increased expression of NHSL1 mRNA CTD PMID:23649840 NCBI chr10:18,193,419...18,409,640
Ensembl chr10:18,194,733...18,409,640
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Vincristine results in increased expression of NINJ1 mRNA CTD PMID:23649840 NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720
JBrowse link
G Nisch nischarin decreases expression ISO Vincristine results in decreased expression of NISCH mRNA CTD PMID:23649840 NCBI chr14:30,892,885...30,928,783
Ensembl chr14:30,892,887...30,938,903
JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 decreases response to substance EXP NMNAT3 protein results in decreased susceptibility to Vincristine CTD PMID:18463239 NCBI chr 9:98,169,487...98,302,586
Ensembl chr 9:98,169,488...98,302,491
JBrowse link
G Nmrk2 nicotinamide riboside kinase 2 decreases response to substance ISO ITGB1BP3 mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr10:81,034,004...81,037,871
Ensembl chr10:81,034,004...81,037,885
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Vincristine results in decreased expression of NNT mRNA CTD PMID:23649840 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533
JBrowse link
G Nol12 nucleolar protein 12 decreases expression ISO Vincristine results in decreased expression of NOL12 mRNA CTD PMID:23649840 NCBI chr15:78,819,151...78,826,111
Ensembl chr15:78,819,133...78,827,838
JBrowse link
G Nol4l nucleolar protein 4-like increases expression ISO Vincristine results in increased expression of NOL4L mRNA CTD PMID:23649840 NCBI chr 2:153,249,381...153,371,869
Ensembl chr 2:153,249,382...153,371,891
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal decreases expression EXP Vincristine results in decreased expression of NOS1 protein CTD PMID:16098672 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase increases expression ISO Vincristine results in increased expression of NPL mRNA CTD PMID:23649840 NCBI chr 1:153,378,762...153,425,460
Ensembl chr 1:153,378,761...153,425,791
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 decreases activity
multiple interactions
ISO Vincristine results in decreased activity of NQO1 protein
Quercetin inhibits the reaction [Vincristine results in decreased activity of NQO1 protein]
CTD PMID:33038355 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Vincristine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Vincristine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Vincristine results in increased expression of ABCB1 protein] CTD PMID:20041327 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression ISO Vincristine results in decreased expression of NR2F2 mRNA CTD PMID:23649840 NCBI chr 7:70,001,694...70,016,494
Ensembl chr 7:70,001,692...70,016,483
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression ISO Vincristine results in increased expression of NR5A2 mRNA CTD PMID:23649840 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Vincristine results in decreased expression of NREP mRNA CTD PMID:23649840 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Vincristine results in decreased expression of NRN1 mRNA CTD PMID:23649840 NCBI chr13:36,909,596...36,918,451
Ensembl chr13:36,909,335...36,919,105
JBrowse link
G Nsmce4a NSE4 homolog A, SMC5-SMC6 complex component decreases expression ISO Vincristine results in decreased expression of NSMCE4A mRNA CTD PMID:23649840 NCBI chr 7:130,134,256...130,149,111
Ensembl chr 7:130,134,256...130,174,848
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Vincristine results in increased expression of NT5E mRNA CTD PMID:23649840 NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145
JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO Vincristine results in decreased expression of NUDT7 mRNA CTD PMID:23649840 NCBI chr 8:114,860,314...114,881,471
Ensembl chr 8:114,860,297...114,881,479
JBrowse link
G Nuf2 NUF2, NDC80 kinetochore complex component increases expression ISO Vincristine results in increased expression of NUF2 mRNA CTD PMID:23649840 NCBI chr 1:169,325,503...169,359,033
Ensembl chr 1:169,325,503...169,359,033
JBrowse link
G Numb NUMB endocytic adaptor protein increases expression ISO Vincristine results in increased expression of NUMB mRNA CTD PMID:23649840 NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708
JBrowse link
G Nup153 nucleoporin 153 increases expression ISO Vincristine results in increased expression of NUP153 mRNA CTD PMID:23649840 NCBI chr13:46,833,369...46,890,682
Ensembl chr13:46,833,381...46,881,416
JBrowse link
G Nxt1 NTF2-related export protein 1 decreases expression ISO Vincristine results in decreased expression of NXT1 mRNA CTD PMID:23649840 NCBI chr 2:148,514,535...148,517,946
Ensembl chr 2:148,514,521...148,517,947
JBrowse link
G Oga O-GlcNAcase increases expression ISO Vincristine results in increased expression of OGA mRNA CTD PMID:23649840 NCBI chr19:45,738,698...45,772,274
Ensembl chr19:45,738,698...45,772,276
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression ISO Vincristine results in decreased expression of OGG1 mRNA CTD PMID:23649840 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) decreases expression ISO Vincristine results in decreased expression of OGT mRNA CTD PMID:23649840 NCBI chr  X:100,683,617...100,727,957
Ensembl chr  X:100,683,666...100,727,957
JBrowse link
G Olah oleoyl-ACP hydrolase increases expression ISO Vincristine results in increased expression of OLAH mRNA CTD PMID:23649840 NCBI chr 2:3,343,019...3,367,964
Ensembl chr 2:3,343,019...3,398,247
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 decreases expression ISO Vincristine results in decreased expression of ORAI1 mRNA CTD PMID:23649840 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519
JBrowse link
G Otp orthopedia homeobox increases expression ISO Vincristine results in increased expression of OTP mRNA CTD PMID:23649840 NCBI chr13:95,012,144...95,021,633
Ensembl chr13:95,012,110...95,021,638
JBrowse link
G Oxtr oxytocin receptor affects response to substance EXP OXTR protein affects the susceptibility to Vincristine CTD PMID:33429010 NCBI chr 6:112,450,646...112,467,800
Ensembl chr 6:112,450,644...112,466,904
JBrowse link
G P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 decreases expression ISO Vincristine results in decreased expression of P2RX5 mRNA CTD PMID:23649840 NCBI chr11:73,029,164...73,063,509
Ensembl chr11:73,051,247...73,063,511
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO [(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Vincristine CTD PMID:16982702 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide decreases expression ISO Vincristine results in decreased expression of P4HA1 mRNA CTD PMID:23649840 NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126
JBrowse link
G Pabpc1l poly(A) binding protein, cytoplasmic 1-like decreases expression ISO Vincristine results in decreased expression of PABPC1L mRNA CTD PMID:23649840 NCBI chr 2:163,866,685...163,892,458
Ensembl chr 2:163,867,370...163,892,458
JBrowse link
G Pabpn1 poly(A) binding protein, nuclear 1 decreases expression ISO Vincristine results in decreased expression of PABPN1 mRNA CTD PMID:23649840 NCBI chr14:55,131,600...55,136,384
Ensembl chr14:55,129,957...55,135,626
JBrowse link
G Paip1 polyadenylate binding protein-interacting protein 1 decreases expression ISO Vincristine results in decreased expression of PAIP1 mRNA CTD PMID:23649840 NCBI chr13:119,564,960...119,596,858
Ensembl chr13:119,565,137...119,594,754
JBrowse link
G Pank2 pantothenate kinase 2 decreases expression ISO Vincristine results in decreased expression of PANK2 mRNA CTD PMID:23649840 NCBI chr 2:131,103,928...131,141,108
Ensembl chr 2:131,104,415...131,141,108
JBrowse link
G Paqr4 progestin and adipoQ receptor family member IV decreases expression ISO Vincristine results in decreased expression of PAQR4 mRNA CTD PMID:23649840 NCBI chr17:23,955,160...23,959,873
Ensembl chr17:23,955,160...23,959,841
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO [CEP 33779 results in increased susceptibility to Vincristine] which results in increased cleavage of PARP1 protein; [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased cleavage of PARP1 protein CTD PMID:28669723 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Parp2 poly (ADP-ribose) polymerase family, member 2 decreases expression ISO Vincristine results in decreased expression of PARP2 mRNA CTD PMID:23649840 NCBI chr14:51,045,347...51,058,758
Ensembl chr14:51,045,298...51,058,758
JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 increases expression ISO Vincristine results in increased expression of PARP9 mRNA CTD PMID:23649840 NCBI chr16:35,759,360...35,792,975
Ensembl chr16:35,758,840...35,792,975
JBrowse link
G Patl1 protein associated with topoisomerase II homolog 1 (yeast) decreases expression ISO Vincristine results in decreased expression of PATL1 mRNA CTD PMID:23649840 NCBI chr19:11,889,728...11,922,462
Ensembl chr19:11,889,763...11,922,455
JBrowse link
G Pbxip1 pre B cell leukemia transcription factor interacting protein 1 increases expression ISO Vincristine results in increased expression of PBXIP1 mRNA CTD PMID:23649840 NCBI chr 3:89,343,982...89,358,259
Ensembl chr 3:89,344,013...89,358,259
JBrowse link
G Pced1b PC-esterase domain containing 1B decreases expression ISO Vincristine results in decreased expression of PCED1B mRNA CTD PMID:23649840 NCBI chr15:97,143,563...97,283,574
Ensembl chr15:97,144,988...97,283,561
JBrowse link
G Pcf11 PCF11 cleavage and polyadenylation factor subunit decreases expression ISO Vincristine results in decreased expression of PCF11 mRNA CTD PMID:23649840 NCBI chr 7:92,292,666...92,319,284
Ensembl chr 7:92,292,751...92,319,142
JBrowse link
G Pcgf2 polycomb group ring finger 2 decreases expression ISO Vincristine results in decreased expression of PCGF2 mRNA CTD PMID:23649840 NCBI chr11:97,579,647...97,593,260
Ensembl chr11:97,579,649...97,591,323
JBrowse link
G Pcnx1 pecanex 1 increases expression ISO Vincristine results in increased expression of PCNX1 mRNA CTD PMID:23649840 NCBI chr12:81,906,688...82,047,698
Ensembl chr12:81,906,797...82,047,698
JBrowse link
G Pcnx2 pecanex homolog 2 increases expression ISO Vincristine results in increased expression of PCNX2 mRNA CTD PMID:23649840 NCBI chr 8:126,478,243...126,625,056
Ensembl chr 8:126,478,247...126,625,056
JBrowse link
G Pcsk7 proprotein convertase subtilisin/kexin type 7 increases expression ISO Vincristine results in increased expression of PCSK7 mRNA CTD PMID:23649840 NCBI chr 9:45,817,745...45,843,405
Ensembl chr 9:45,817,795...45,841,024
JBrowse link
G Pdcd5 programmed cell death 5 decreases expression ISO Vincristine results in decreased expression of PDCD5 mRNA CTD PMID:23649840 NCBI chr 7:35,341,410...35,346,907
Ensembl chr 7:35,341,407...35,346,946
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific increases expression ISO Vincristine results in increased expression of PDE4B mRNA CTD PMID:23649840 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 decreases expression ISO Vincristine results in decreased expression of PDK1 mRNA CTD PMID:23649840 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 decreases expression ISO Vincristine results in decreased expression of PDK3 mRNA CTD PMID:23649840 NCBI chr  X:92,798,923...92,875,756
Ensembl chr  X:92,808,213...92,875,807
JBrowse link
G Pds5b PDS5 cohesin associated factor B increases expression ISO Vincristine results in increased expression of PDS5B mRNA CTD PMID:23649840 NCBI chr 5:150,597,178...150,734,174
Ensembl chr 5:150,597,204...150,734,155
JBrowse link
G Pea15a proliferation and apoptosis adaptor protein 15A increases expression ISO Vincristine results in increased expression of PEA15 mRNA CTD PMID:23649840 NCBI chr 1:172,024,295...172,034,298
Ensembl chr 1:172,024,295...172,034,371
JBrowse link
G Peli1 pellino 1 decreases expression ISO Vincristine results in decreased expression of PELI1 mRNA CTD PMID:23649840 NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323
JBrowse link
G Pex11b peroxisomal biogenesis factor 11 beta decreases expression ISO Vincristine results in decreased expression of PEX11B mRNA CTD PMID:23649840 NCBI chr 3:96,542,673...96,552,697
Ensembl chr 3:96,542,692...96,552,682
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 decreases expression ISO Vincristine results in decreased expression of PEX13 mRNA CTD PMID:23649840 NCBI chr11:23,597,283...23,615,883
Ensembl chr11:23,596,479...23,615,959
JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) decreases expression ISO Vincristine results in decreased expression of PFAS mRNA CTD PMID:23649840 NCBI chr11:68,876,527...68,899,286
Ensembl chr11:68,876,523...68,899,286
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 decreases expression ISO Vincristine results in decreased expression of PFKFB4 mRNA CTD PMID:23649840 NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296
JBrowse link
G Pgm1 phosphoglucomutase 1 decreases expression ISO Vincristine results in decreased expression of PGM1 mRNA CTD PMID:23649840 NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491
JBrowse link
G Pgp phosphoglycolate phosphatase decreases expression ISO Vincristine results in decreased expression of PGP mRNA CTD PMID:23649840 NCBI chr17:24,689,400...24,692,084
Ensembl chr17:24,689,366...24,692,084
JBrowse link
G Phf11d PHD finger protein 11D increases expression ISO Vincristine results in increased expression of PHF11 mRNA CTD PMID:23649840 NCBI chr14:59,584,646...59,608,004
Ensembl chr14:59,584,856...59,602,919
JBrowse link
G Phf6 PHD finger protein 6 decreases expression ISO Vincristine results in decreased expression of PHF6 mRNA CTD PMID:23649840 NCBI chr  X:52,001,091...52,045,838
Ensembl chr  X:52,001,143...52,045,820
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 decreases expression ISO Vincristine results in decreased expression of PHTF2 mRNA CTD PMID:23649840 NCBI chr 5:20,963,662...21,087,122
Ensembl chr 5:20,963,661...21,087,122
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha increases expression ISO Vincristine results in increased expression of PIK3C2A mRNA CTD PMID:23649840 NCBI chr 7:115,936,500...116,042,693
Ensembl chr 7:115,936,500...116,042,684
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation
multiple interactions
ISO Vincristine results in decreased phosphorylation of PIK3R1 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Vincristine results in decreased phosphorylation of PIK3R1 protein]; bisphenol A inhibits the reaction [Vincristine results in decreased phosphorylation of PIK3R1 protein]; perfluorooctanoic acid inhibits the reaction [Vincristine results in decreased phosphorylation of PIK3R1 protein]
CTD PMID:36181250 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 decreases expression ISO Vincristine results in decreased expression of PIK3R2 mRNA CTD PMID:23649840 NCBI chr 8:71,220,820...71,229,356
Ensembl chr 8:71,220,820...71,229,357
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha increases expression ISO Vincristine results in increased expression of PILRA mRNA CTD PMID:23649840 NCBI chr 5:137,820,214...137,834,540
Ensembl chr 5:137,820,214...137,834,543
JBrowse link
G Pim2 proviral integration site 2 increases expression ISO Vincristine results in increased expression of PIM2 mRNA CTD PMID:23649840 NCBI chr  X:7,744,545...7,749,671
Ensembl chr  X:7,744,501...7,749,671
JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta decreases expression ISO Vincristine results in decreased expression of PITPNB mRNA CTD PMID:23649840 NCBI chr 5:111,478,563...111,536,225
Ensembl chr 5:111,478,629...111,536,225
JBrowse link
G Pkig protein kinase inhibitor, gamma increases expression ISO Vincristine results in increased expression of PKIG mRNA CTD PMID:23649840 NCBI chr 2:163,500,306...163,568,078
Ensembl chr 2:163,500,306...163,568,078
JBrowse link
G Pla1a phospholipase A1 member A increases expression ISO Vincristine results in increased expression of PLA1A mRNA CTD PMID:23649840 NCBI chr16:38,214,245...38,253,553
Ensembl chr16:38,216,479...38,253,507
JBrowse link
G Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) increases expression ISO Vincristine results in increased expression of PLA2G4C mRNA CTD PMID:23649840 NCBI chr 7:13,045,432...13,094,597
Ensembl chr 7:13,058,580...13,094,597
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Vincristine results in increased expression of PLAT mRNA CTD PMID:20624997 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Vincristine results in increased expression of PLAUR mRNA CTD PMID:20624997 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 decreases expression ISO Vincristine results in decreased expression of PLCXD1 mRNA CTD PMID:23649840 NCBI chr 5:110,247,661...110,253,819
Ensembl chr 5:110,247,835...110,253,819
JBrowse link
G Plek pleckstrin increases expression ISO Vincristine results in increased expression of PLEK mRNA CTD PMID:23649840 NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381
JBrowse link
G Plekha2 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 decreases expression ISO Vincristine results in decreased expression of PLEKHA2 mRNA CTD PMID:23649840 NCBI chr 8:25,529,160...25,594,684
Ensembl chr 8:25,529,160...25,592,392
JBrowse link
G Plekhg1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 increases expression ISO Vincristine results in increased expression of PLEKHG1 mRNA CTD PMID:23649840 NCBI chr10:3,690,206...3,917,303
Ensembl chr10:3,690,364...3,917,303
JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression ISO Vincristine results in increased expression of PLPP3 mRNA CTD PMID:23649840 NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961
JBrowse link
G Pm20d2 peptidase M20 domain containing 2 decreases expression ISO Vincristine results in decreased expression of PM20D2 mRNA CTD PMID:23649840 NCBI chr 4:33,170,309...33,189,732
Ensembl chr 4:33,174,230...33,189,737
JBrowse link
G Pmp22 peripheral myelin protein 22 increases response to substance ISO PMP22 gene mutant form results in increased susceptibility to Vincristine CTD PMID:12427913 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component decreases expression ISO Vincristine results in decreased expression of PMS1 mRNA CTD PMID:23649840 NCBI chr 1:53,225,794...53,336,190
Ensembl chr 1:53,228,346...53,336,177
JBrowse link
G Pnisr PNN interacting serine/arginine-rich decreases expression ISO Vincristine results in decreased expression of PNISR mRNA CTD PMID:23649840 NCBI chr 4:21,846,621...21,876,475
Ensembl chr 4:21,847,583...21,876,475
JBrowse link
G Pnoc prepronociceptin decreases expression ISO Vincristine results in decreased expression of PNOC mRNA CTD PMID:23649840 NCBI chr14:65,638,931...65,662,908
Ensembl chr14:65,638,122...65,662,921
JBrowse link
G Poglut1 protein O-glucosyltransferase 1 increases expression ISO Vincristine results in increased expression of POGLUT1 mRNA CTD PMID:23649840 NCBI chr16:38,345,420...38,370,619
Ensembl chr16:38,345,499...38,370,620
JBrowse link
G Pogz pogo transposable element with ZNF domain increases expression ISO Vincristine results in increased expression of POGZ mRNA CTD PMID:23649840 NCBI chr 3:94,730,289...94,790,888
Ensembl chr 3:94,744,878...94,789,637
JBrowse link
G Pola1 polymerase (DNA directed), alpha 1 decreases expression ISO Vincristine results in decreased expression of POLA1 mRNA CTD PMID:23649840 NCBI chr  X:92,348,372...92,675,993
Ensembl chr  X:92,348,373...92,675,761
JBrowse link
G Pold3 polymerase (DNA-directed), delta 3, accessory subunit decreases expression ISO Vincristine results in decreased expression of POLD3 mRNA CTD PMID:23649840 NCBI chr 7:99,731,317...99,770,709
Ensembl chr 7:99,731,318...99,770,772
JBrowse link
G Polq polymerase (DNA directed), theta increases expression ISO Vincristine results in increased expression of POLQ mRNA CTD PMID:23649840 NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779
JBrowse link
G Polr1b polymerase (RNA) I polypeptide B decreases expression ISO Vincristine results in decreased expression of POLR1B mRNA CTD PMID:23649840 NCBI chr 2:128,942,891...128,969,980
Ensembl chr 2:128,942,915...128,968,514
JBrowse link
G Polr1h RNA polymerase I subunit H decreases response to substance
multiple interactions
ISO POLR1H protein results in decreased susceptibility to Vincristine
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Vincristine]
CTD PMID:14726695 NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451
JBrowse link
G Postn periostin, osteoblast specific factor decreases response to substance ISO POSTN mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458
JBrowse link
G Pou2af1 POU domain, class 2, associating factor 1 decreases expression ISO Vincristine results in decreased expression of POU2AF1 mRNA CTD PMID:23649840 NCBI chr 9:51,124,990...51,151,379
Ensembl chr 9:51,125,008...51,151,380
JBrowse link
G Pou2f1 POU domain, class 2, transcription factor 1 decreases expression ISO Vincristine results in decreased expression of POU2F1 mRNA CTD PMID:23649840 NCBI chr 1:165,692,719...165,830,318
Ensembl chr 1:165,692,723...165,830,247
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression
multiple interactions
ISO Vincristine results in decreased expression of PPARGC1A protein
Quercetin inhibits the reaction [Vincristine results in decreased expression of PPARGC1A protein]
CTD PMID:36808657 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform increases expression ISO Vincristine results in increased expression of PPM1A mRNA CTD PMID:23649840 NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 increases expression ISO Vincristine results in increased expression of PPP1R10 mRNA CTD PMID:23649840 NCBI chr17:36,227,404...36,243,175
Ensembl chr17:36,227,326...36,243,175
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Vincristine results in increased expression of PPP1R15A mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B increases response to substance ISO PPP1R1B protein results in increased susceptibility to Vincristine CTD PMID:17470401 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Ppp1r3e protein phosphatase 1, regulatory subunit 3E decreases expression ISO Vincristine results in decreased expression of PPP1R3E mRNA CTD PMID:23649840 NCBI chr14:55,113,054...55,114,995
Ensembl chr14:55,110,126...55,115,007
JBrowse link
G Ppp4r3b protein phosphatase 4 regulatory subunit 3B decreases expression ISO Vincristine results in decreased expression of PPP4R3B mRNA CTD PMID:23649840 NCBI chr11:29,118,053...29,170,797
Ensembl chr11:29,122,890...29,170,797
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Vincristine results in increased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007
JBrowse link
G Prim1 DNA primase, p49 subunit decreases expression ISO Vincristine results in decreased expression of PRIM1 mRNA CTD PMID:23649840 NCBI chr10:127,851,084...127,865,899
Ensembl chr10:127,851,041...127,865,906
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Vincristine affects the localization of PRKCD protein CTD PMID:9852137 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prkce protein kinase C, epsilon increases response to substance ISO PRKCE protein results in increased susceptibility to Vincristine CTD PMID:12809704 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide increases expression ISO Vincristine results in increased expression of PRKDC mRNA CTD PMID:23649840 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Prlr prolactin receptor increases expression ISO Vincristine results in increased expression of PRLR mRNA CTD PMID:23649840 NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266
JBrowse link
G Prnp prion protein decreases response to substance ISO PRNP protein results in decreased susceptibility to Vincristine CTD PMID:15386405 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
JBrowse link
G Prpf4b pre-mRNA processing factor 4B decreases expression ISO Vincristine results in decreased expression of PRP4K mRNA CTD PMID:23649840 NCBI chr13:35,058,803...35,090,047
Ensembl chr13:35,059,285...35,090,047
JBrowse link
G Prr12 proline rich 12 decreases expression ISO Vincristine results in decreased expression of PRR12 mRNA CTD PMID:23649840 NCBI chr 7:44,677,125...44,702,758
Ensembl chr 7:44,676,987...44,702,305
JBrowse link
G Prr3 proline-rich polypeptide 3 decreases expression ISO Vincristine results in decreased expression of PRR3 mRNA CTD PMID:23649840 NCBI chr17:36,283,431...36,291,136
Ensembl chr17:36,283,433...36,291,128
JBrowse link
G Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) increases expression ISO Vincristine results in increased expression of PRRG4 mRNA CTD PMID:23649840 NCBI chr 2:104,657,374...104,680,216
Ensembl chr 2:104,661,086...104,680,221
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 increases expression ISO Vincristine results in increased expression of PSD3 mRNA CTD PMID:23649840 NCBI chr 8:68,141,728...68,664,740
Ensembl chr 8:68,141,734...68,664,679
JBrowse link
G Psme4 proteasome (prosome, macropain) activator subunit 4 increases expression ISO Vincristine results in increased expression of PSME4 mRNA CTD PMID:23649840 NCBI chr11:30,721,753...30,831,150
Ensembl chr11:30,721,726...30,830,361
JBrowse link
G Psmg4 proteasome (prosome, macropain) assembly chaperone 4 increases expression ISO Vincristine results in increased expression of PSMG4 mRNA CTD PMID:23649840 NCBI chr13:34,346,947...34,362,155
Ensembl chr13:34,346,947...34,362,156
JBrowse link
G Pspc1 paraspeckle protein 1 decreases expression ISO Vincristine results in decreased expression of PSPC1 mRNA CTD PMID:23649840 NCBI chr14:56,959,898...57,015,775
Ensembl chr14:56,958,167...57,015,773
JBrowse link
G Ptafr platelet-activating factor receptor increases expression ISO Vincristine results in increased expression of PTAFR mRNA CTD PMID:23649840 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) increases expression ISO Vincristine results in increased expression of PTGER4 mRNA CTD PMID:23649840 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668
JBrowse link
G Ptgr2 prostaglandin reductase 2 decreases expression ISO Vincristine results in decreased expression of PTGR2 mRNA CTD PMID:23649840 NCBI chr12:84,332,011...84,362,606
Ensembl chr12:84,332,006...84,362,606
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP KN 93 inhibits the reaction [Vincristine results in increased expression of PTGS2 mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of PTGS2 protein]
Vincristine results in increased expression of PTGS2 mRNA; Vincristine results in increased expression of PTGS2 protein
CTD PMID:34286406 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta increases phosphorylation ISO Vincristine results in increased phosphorylation of PTK2B protein CTD PMID:11478917 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 decreases expression ISO Vincristine results in decreased expression of PTPN11 mRNA CTD PMID:23649840 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 increases expression ISO Vincristine results in increased expression of PTPN13 mRNA CTD PMID:23649840 NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 increases expression ISO Vincristine results in increased expression of PTPN3 mRNA CTD PMID:23649840 NCBI chr 4:57,190,841...57,339,036
Ensembl chr 4:57,190,841...57,301,837
JBrowse link
G Ptprk protein tyrosine phosphatase receptor type K increases expression ISO Vincristine results in increased expression of PTPRK mRNA CTD PMID:23649840 NCBI chr10:27,950,406...28,473,393
Ensembl chr10:27,950,816...28,473,393
JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O increases expression ISO Vincristine results in increased expression of PTPRO mRNA CTD PMID:23649840 NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231
JBrowse link
G Ptprr protein tyrosine phosphatase receptor type R increases expression ISO Vincristine results in increased expression of PTPRR mRNA CTD PMID:23649840 NCBI chr10:115,854,093...116,110,837
Ensembl chr10:115,854,118...116,110,837
JBrowse link
G Pvrig poliovirus receptor related immunoglobulin domain containing decreases expression ISO Vincristine results in decreased expression of PVRIG mRNA CTD PMID:23649840 NCBI chr 5:138,340,193...138,346,953
Ensembl chr 5:138,340,223...138,341,819
JBrowse link
G Pxt1 peroxisomal, testis specific 1 increases expression ISO Vincristine results in increased expression of PXT1 mRNA CTD PMID:23649840 NCBI chr17:29,152,960...29,161,236
Ensembl chr17:29,152,958...29,162,814
JBrowse link
G Qrich1 glutamine-rich 1 increases phosphorylation ISO Vincristine results in increased phosphorylation of QRICH1 protein CTD PMID:17510977 NCBI chr 9:108,394,010...108,437,366
Ensembl chr 9:108,394,005...108,437,362
JBrowse link
G Rab11fip1 RAB11 family interacting protein 1 (class I) increases expression ISO Vincristine results in increased expression of RAB11FIP1 mRNA CTD PMID:23649840 NCBI chr 8:27,628,801...27,664,707
Ensembl chr 8:27,628,801...27,664,674
JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 (class II) increases expression ISO Vincristine results in increased expression of RAB11FIP3 mRNA CTD PMID:23649840 NCBI chr17:26,208,010...26,289,010
Ensembl chr17:26,208,010...26,288,529
JBrowse link
G Rab12 RAB12, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB12 mRNA CTD PMID:23649840 NCBI chr17:66,801,507...66,826,712
Ensembl chr17:66,801,507...66,826,724
JBrowse link
G Rab20 RAB20, member RAS oncogene family decreases expression ISO Vincristine results in decreased expression of RAB20 mRNA CTD PMID:23649840 NCBI chr 8:11,503,390...11,528,640
Ensembl chr 8:11,503,518...11,528,710
JBrowse link
G Rab21 RAB21, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB21 mRNA CTD PMID:23649840 NCBI chr10:115,125,767...115,151,540
Ensembl chr10:115,122,989...115,151,499
JBrowse link
G Rab29 RAB29, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB29 mRNA CTD PMID:23649840 NCBI chr 1:131,795,004...131,801,003
Ensembl chr 1:131,794,962...131,800,625
JBrowse link
G Rab39b RAB39B, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB39B mRNA CTD PMID:23649840 NCBI chr  X:74,615,651...74,621,837
Ensembl chr  X:74,615,652...74,621,837
JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB8B mRNA CTD PMID:23649840 NCBI chr 9:66,750,891...66,826,987
Ensembl chr 9:66,750,946...66,826,969
JBrowse link
G Rab9 RAB9, member RAS oncogene family increases expression ISO Vincristine results in increased expression of RAB9A mRNA CTD PMID:23649840 NCBI chr  X:165,240,247...165,262,863
Ensembl chr  X:165,240,249...165,262,863
JBrowse link
G Rabggtb Rab geranylgeranyl transferase, b subunit decreases expression ISO Vincristine results in decreased expression of RABGGTB mRNA CTD PMID:23649840 NCBI chr 3:153,612,926...153,618,603
Ensembl chr 3:153,612,924...153,618,646
JBrowse link
G Rabif RAB interacting factor decreases expression ISO Vincristine results in decreased expression of RABIF mRNA CTD PMID:23649840 NCBI chr 1:134,422,377...134,435,627
Ensembl chr 1:134,422,386...134,436,512
JBrowse link
G Rac2 Rac family small GTPase 2 affects response to substance EXP RAC2 protein affects the susceptibility to Vincristine CTD PMID:19783987 NCBI chr15:78,443,369...78,456,983
Ensembl chr15:78,443,367...78,456,983
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO Vincristine results in decreased expression of RACK1 mRNA CTD PMID:23649840 NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261
JBrowse link
G Rad54l RAD54 like (S. cerevisiae) decreases expression ISO Vincristine results in decreased expression of RAD54L mRNA CTD PMID:23649840 NCBI chr 4:115,951,458...115,980,875
Ensembl chr 4:115,951,461...115,980,887
JBrowse link
G Rasef RAS and EF hand domain containing increases expression ISO Vincristine results in increased expression of RASEF mRNA CTD PMID:23649840 NCBI chr 4:73,632,814...73,709,382
Ensembl chr 4:73,632,816...73,709,231
JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 increases expression ISO Vincristine results in increased expression of RASSF1 mRNA CTD PMID:20624997 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
JBrowse link
G Rassf4 Ras association (RalGDS/AF-6) domain family member 4 increases expression ISO Vincristine results in increased expression of RASSF4 mRNA CTD PMID:23649840 NCBI chr 6:116,609,969...116,650,797
Ensembl chr 6:116,609,969...116,650,913
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [CEP 33779 results in increased susceptibility to Vincristine] which results in increased phosphorylation of RB1 protein; [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased phosphorylation of RB1 protein; [XL019 compound co-treated with Vincristine] results in increased expression of and results in increased phosphorylation of RB1 protein modified form CTD PMID:28669723 PMID:29187454 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor increases expression ISO Vincristine results in increased expression of RBBP4 mRNA CTD PMID:23649840 NCBI chr 4:129,200,893...129,229,163
Ensembl chr 4:129,200,893...129,229,163
JBrowse link
G Rbbp8 retinoblastoma binding protein 8, endonuclease decreases expression ISO Vincristine results in decreased expression of RBBP8 mRNA CTD PMID:23649840 NCBI chr18:11,766,333...11,876,264
Ensembl chr18:11,766,333...11,878,278
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Vincristine results in decreased expression of RBL1 mRNA CTD PMID:23649840 NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454
JBrowse link
G Rbm12 RNA binding motif protein 12 decreases expression ISO Vincristine results in decreased expression of RBM12 mRNA CTD PMID:23649840 NCBI chr 2:155,933,876...155,953,847
Ensembl chr 2:155,933,878...155,953,898
JBrowse link
G Rbm15 RNA binding motif protein 15 decreases expression ISO Vincristine results in decreased expression of RBM15 mRNA CTD PMID:23649840 NCBI chr 3:107,212,827...107,244,102
Ensembl chr 3:107,232,737...107,240,989
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Vincristine CTD PMID:16061639 NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964
JBrowse link
G Rbm18 RNA binding motif protein 18 increases expression ISO Vincristine results in increased expression of RBM18 mRNA CTD PMID:23649840 NCBI chr 2:36,006,091...36,026,716
Ensembl chr 2:36,006,091...36,026,785
JBrowse link
G Rbm25 RNA binding motif protein 25 decreases expression ISO Vincristine results in decreased expression of RBM25 mRNA CTD PMID:23649840 NCBI chr12:83,678,990...83,729,901
Ensembl chr12:83,678,010...83,729,897
JBrowse link
G Rbm4b RNA binding motif protein 4B decreases expression ISO Vincristine results in decreased expression of RBM4B mRNA CTD PMID:23649840 NCBI chr19:4,806,480...4,816,199
Ensembl chr19:4,806,525...4,817,093
JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Vincristine results in decreased expression of RBM5 mRNA CTD PMID:23649840 NCBI chr 9:107,617,694...107,648,228
Ensembl chr 9:107,617,570...107,648,195
JBrowse link
G Rbm6 RNA binding motif protein 6 decreases expression ISO Vincristine results in decreased expression of RBM6 mRNA CTD PMID:23649840 NCBI chr 9:107,650,758...107,751,028
Ensembl chr 9:107,650,758...107,750,436
JBrowse link
G Rbm8a RNA binding motif protein 8a decreases expression ISO Vincristine results in decreased expression of RBM8A mRNA CTD PMID:23649840 NCBI chr 3:96,537,244...96,541,107
Ensembl chr 3:96,537,249...96,541,107
JBrowse link
G Rcc1l reculator of chromosome condensation 1 like increases expression ISO Vincristine results in increased expression of RCC1L mRNA CTD PMID:23649840 NCBI chr 5:134,176,897...134,207,963
Ensembl chr 5:134,176,893...134,205,613
JBrowse link
G Recql4 RecQ protein-like 4 decreases expression ISO Vincristine results in decreased expression of RECQL4 mRNA CTD PMID:23649840 NCBI chr15:76,587,753...76,594,820
Ensembl chr15:76,587,753...76,594,748
JBrowse link
G Rel reticuloendotheliosis oncogene increases expression ISO Vincristine results in increased expression of REL mRNA CTD PMID:23649840 NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression
increases phosphorylation
ISO
EXP
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein]; Sumatriptan inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein]
KN 93 inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein]
CTD PMID:29958920 PMID:34286406 PMID:34939713 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Reps1 RalBP1 associated Eps domain containing protein increases expression ISO Vincristine results in increased expression of REPS1 mRNA CTD PMID:23649840 NCBI chr10:17,931,301...18,000,892
Ensembl chr10:17,931,609...18,000,903
JBrowse link
G Rev1 REV1, DNA directed polymerase decreases expression ISO Vincristine results in decreased expression of REV1 mRNA CTD PMID:23649840 NCBI chr 1:38,091,867...38,169,191
Ensembl chr 1:38,091,867...38,168,882
JBrowse link
G Rffl ring finger and FYVE like domain containing protein increases expression ISO Vincristine results in increased expression of RFFL mRNA CTD PMID:23649840 NCBI chr11:82,694,645...82,762,065
Ensembl chr11:82,693,275...82,762,036
JBrowse link
G Rftn1 raftlin lipid raft linker 1 increases expression ISO Vincristine results in increased expression of RFTN1 mRNA CTD PMID:23649840 NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702
JBrowse link
G Rgl1 ral guanine nucleotide dissociation stimulator,-like 1 increases expression ISO Vincristine results in increased expression of RGL1 mRNA CTD PMID:23649840 NCBI chr 1:152,392,513...152,642,056
Ensembl chr 1:152,392,511...152,642,102
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Vincristine results in increased expression of RGS1 mRNA CTD PMID:23649840 NCBI chr 1:144,120,407...144,124,862
Ensembl chr 1:144,118,034...144,124,980
JBrowse link
G Rgs10 regulator of G-protein signalling 10 increases response to substance ISO RGS10 protein results in increased susceptibility to Vincristine CTD PMID:21044322 NCBI chr 7:127,975,345...128,020,993
Ensembl chr 7:127,975,345...128,020,482
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Vincristine results in increased expression of RGS16 mRNA CTD PMID:23649840 NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
JBrowse link
G Rgs17 regulator of G-protein signaling 17 increases response to substance ISO RGS17 protein results in increased susceptibility to Vincristine CTD PMID:21044322 NCBI chr10:5,775,663...5,872,413
Ensembl chr10:5,775,663...5,872,400
JBrowse link
G Rhof ras homolog family member F (in filopodia) increases expression ISO Vincristine results in increased expression of RHOF mRNA CTD PMID:23649840 NCBI chr 5:123,256,243...123,270,692
Ensembl chr 5:123,241,107...123,270,755
JBrowse link
G Rhoq ras homolog family member Q increases expression ISO Vincristine results in increased expression of RHOQ mRNA CTD PMID:23649840 NCBI chr17:87,270,539...87,307,497
Ensembl chr17:87,270,510...87,307,497
JBrowse link
G Rif1 replication timing regulatory factor 1 decreases expression ISO Vincristine results in decreased expression of RIF1 mRNA CTD PMID:23649840 NCBI chr 2:51,962,725...52,016,781
Ensembl chr 2:51,962,844...52,012,395
JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 increases expression ISO Vincristine results in increased expression of RIPK2 mRNA CTD PMID:23649840 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647
JBrowse link
G Rnase6 ribonuclease, RNase A family, 6 decreases expression ISO Vincristine results in decreased expression of RNASE6 mRNA CTD PMID:23649840 NCBI chr14:51,361,365...51,369,644
Ensembl chr14:51,361,365...51,369,644
JBrowse link
G Rnf144a ring finger protein 144A decreases expression ISO Vincristine results in decreased expression of RNF144A mRNA CTD PMID:23649840 NCBI chr12:26,356,796...26,465,296
Ensembl chr12:26,350,963...26,465,253
JBrowse link
G Rnf19b ring finger protein 19B increases expression ISO Vincristine results in increased expression of RNF19B mRNA CTD PMID:23649840 NCBI chr 4:128,951,871...128,978,319
Ensembl chr 4:128,952,064...128,979,679
JBrowse link
G Rnf213 ring finger protein 213 decreases expression ISO Vincristine results in decreased expression of RNF213 mRNA CTD PMID:23649840 NCBI chr11:119,280,778...119,378,245
Ensembl chr11:119,283,926...119,378,244
JBrowse link
G Rnf34 ring finger protein 34 increases expression ISO Vincristine results in increased expression of RNF34 mRNA CTD PMID:23649840 NCBI chr 5:122,988,270...123,007,008
Ensembl chr 5:122,988,111...123,009,354
JBrowse link
G Rora RAR-related orphan receptor alpha increases expression ISO Vincristine results in increased expression of RORA mRNA CTD PMID:23649840 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528
JBrowse link
G Rpain RPA interacting protein decreases expression ISO Vincristine results in decreased expression of RPAIN mRNA CTD PMID:23649840 NCBI chr11:70,860,403...70,868,759
Ensembl chr11:70,861,039...70,868,659
JBrowse link
G Rpl10 ribosomal protein L10 decreases expression ISO Vincristine results in decreased expression of RPL10 mRNA CTD PMID:23649840 NCBI chr  X:73,314,463...73,316,741
Ensembl chr  X:73,314,418...73,316,741
JBrowse link
G Rpl13 ribosomal protein L13 decreases expression ISO Vincristine results in decreased expression of RPL13 mRNA CTD PMID:23649840 NCBI chr 8:123,829,089...123,831,983
Ensembl chr 8:123,829,089...123,831,983
JBrowse link
G Rpl17 ribosomal protein L17 decreases expression ISO Vincristine results in decreased expression of RPL17 mRNA CTD PMID:23649840 NCBI chr18:75,132,049...75,136,455
Ensembl chr18:75,131,629...75,136,452
JBrowse link
G Rpl31 ribosomal protein L31 decreases expression ISO Vincristine results in decreased expression of RPL31 mRNA CTD PMID:23649840 NCBI chr 1:39,406,987...39,410,992
Ensembl chr 1:39,406,923...39,410,992
JBrowse link
G Rpl37a ribosomal protein L37a decreases expression ISO Vincristine results in decreased expression of RPL37A mRNA CTD PMID:23649840 NCBI chr 1:72,750,426...72,752,972
Ensembl chr 1:72,750,449...72,752,972
JBrowse link
G Rpl5 ribosomal protein L5 decreases expression ISO Vincristine results in decreased expression of RPL5 mRNA CTD PMID:23649840 NCBI chr 5:108,048,388...108,056,871
Ensembl chr 5:108,048,368...108,056,871
JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 protein results in decreased susceptibility to Vincristine CTD PMID:15846068 NCBI chr 5:121,342,564...121,347,304
Ensembl chr 5:121,342,544...121,347,304
JBrowse link
G Rpl7 ribosomal protein L7 decreases expression ISO Vincristine results in decreased expression of RPL7 mRNA CTD PMID:23649840 NCBI chr 1:16,171,519...16,174,657
Ensembl chr 1:16,171,519...16,174,886
JBrowse link
G Rprd1a regulation of nuclear pre-mRNA domain containing 1A decreases expression ISO Vincristine results in decreased expression of RPRD1A mRNA CTD PMID:23649840 NCBI chr18:24,618,017...24,663,306
Ensembl chr18:24,618,017...24,663,261
JBrowse link
G Rps24 ribosomal protein S24 decreases expression ISO Vincristine results in decreased expression of RPS24 mRNA CTD PMID:23649840 NCBI chr14:24,540,786...24,545,925
Ensembl chr14:24,537,193...24,547,027
JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO Vincristine results in increased expression of RPS27L mRNA CTD PMID:23649840 NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798
JBrowse link
G Rragc Ras-related GTP binding C increases expression ISO Vincristine results in increased expression of RRAGC mRNA CTD PMID:23649840 NCBI chr 4:123,811,226...123,830,790
Ensembl chr 4:123,811,239...123,830,790
JBrowse link
G Rrm2 ribonucleotide reductase M2 decreases expression ISO Vincristine results in decreased expression of RRM2 mRNA CTD PMID:23649840 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Rrp7a ribosomal RNA processing 7 homolog A decreases expression ISO Vincristine results in decreased expression of RRP7A mRNA CTD PMID:23649840 NCBI chr15:83,000,047...83,007,002
Ensembl chr15:82,997,634...83,007,002
JBrowse link
G Rskr ribosomal protein S6 kinase related decreases expression ISO Vincristine results in decreased expression of RSKR mRNA CTD PMID:23649840 NCBI chr11:78,181,580...78,187,631
Ensembl chr11:78,181,667...78,187,631
JBrowse link
G Rsrp1 arginine/serine rich protein 1 decreases expression ISO Vincristine results in decreased expression of RSRP1 mRNA CTD PMID:23649840 NCBI chr 4:134,650,936...134,654,681
Ensembl chr 4:134,650,903...134,654,982
JBrowse link
G Runx3 runt related transcription factor 3 increases response to substance ISO RUNX3 protein results in increased susceptibility to Vincristine CTD PMID:15756676 NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301
JBrowse link
G S100a4 S100 calcium binding protein A4 increases expression ISO Vincristine results in increased expression of S100A4 mRNA CTD PMID:23649840 NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Vincristine results in increased expression of S100A8 mRNA CTD PMID:20624997 PMID:21971985 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Vincristine results in increased expression of S100A9 mRNA CTD PMID:20624997 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Samhd1 SAM domain and HD domain, 1 decreases expression ISO Vincristine results in decreased expression of SAMHD1 mRNA CTD PMID:23649840 NCBI chr 2:156,939,454...156,977,016
Ensembl chr 2:156,939,453...156,977,185
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 increases expression ISO Vincristine results in increased expression of SAMSN1 mRNA CTD PMID:23649840 NCBI chr16:75,655,682...75,706,154
Ensembl chr16:75,655,681...75,819,169
JBrowse link
G Sarm1 sterile alpha and HEAT/Armadillo motif containing 1 multiple interactions
increases expression
ISO coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA] CTD PMID:34939713 NCBI chr11:78,361,099...78,388,642
Ensembl chr11:78,363,156...78,388,580
JBrowse link
G Sash3 SAM and SH3 domain containing 3 increases expression ISO Vincristine results in increased expression of SASH3 mRNA CTD PMID:23649840 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Vincristine results in increased expression of SAT1 mRNA CTD PMID:23649840 NCBI chr  X:153,996,128...153,999,345
Ensembl chr  X:153,996,128...153,999,445
JBrowse link
G Sbf2 SET binding factor 2 increases expression ISO Vincristine results in increased expression of SBF2 mRNA CTD PMID:23649840 NCBI chr 7:109,907,218...110,215,150
Ensembl chr 7:109,907,220...110,214,129
JBrowse link
G Sbno1 strawberry notch 1 increases expression ISO Vincristine results in increased expression of SBNO1 mRNA CTD PMID:23649840 NCBI chr 5:124,506,765...124,564,059
Ensembl chr 5:124,506,765...124,564,064
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Vincristine results in increased expression of SCAF11 mRNA CTD PMID:23649840 NCBI chr15:96,309,580...96,358,695
Ensembl chr15:96,309,580...96,358,724
JBrowse link
G Scamp2 secretory carrier membrane protein 2 decreases expression ISO Vincristine results in decreased expression of SCAMP2 mRNA CTD PMID:23649840 NCBI chr 9:57,468,227...57,496,081
Ensembl chr 9:57,468,226...57,496,078
JBrowse link
G Scd3 stearoyl-coenzyme A desaturase 3 increases expression ISO Vincristine results in increased expression of SCD5 mRNA CTD PMID:23649840 NCBI chr19:44,191,727...44,232,455
Ensembl chr19:44,191,708...44,232,455
JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases expression ISO Vincristine results in increased expression of SCLT1 mRNA CTD PMID:23649840 NCBI chr 3:41,581,140...41,696,968
Ensembl chr 3:41,581,155...41,696,949
JBrowse link
G Scly selenocysteine lyase decreases expression ISO Vincristine results in decreased expression of SCLY mRNA CTD PMID:23649840 NCBI chr 1:91,226,017...91,248,797
Ensembl chr 1:91,226,060...91,248,797
JBrowse link
G Sco2 SCO2 cytochrome c oxidase assembly protein decreases expression ISO Vincristine results in decreased expression of SCO2 mRNA CTD PMID:23649840 NCBI chr15:89,255,833...89,258,094
Ensembl chr15:89,255,840...89,258,049
JBrowse link
G Sdcbp syndecan binding protein increases expression ISO Vincristine results in increased expression of SDCBP mRNA CTD PMID:23649840 NCBI chr 4:6,365,713...6,396,120
Ensembl chr 4:6,365,650...6,408,423
JBrowse link
G Sec31b SEC31 homolog B, COPII coat complex component decreases expression ISO Vincristine results in decreased expression of SEC31B mRNA CTD PMID:23649840 NCBI chr19:44,505,396...44,534,287
Ensembl chr19:44,505,396...44,534,303
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation decreases expression ISO Vincristine results in decreased expression of SEC62 mRNA CTD PMID:23649840 NCBI chr 3:30,847,025...30,875,412
Ensembl chr 3:30,847,024...30,875,412
JBrowse link
G Sele selectin, endothelial cell increases expression ISO Vincristine results in increased expression of SELE mRNA CTD PMID:20624997 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Selenoh selenoprotein H decreases expression ISO Vincristine results in decreased expression of SELENOH mRNA CTD PMID:23649840 NCBI chr 2:84,499,559...84,501,052
Ensembl chr 2:84,499,559...84,501,114
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 decreases expression ISO Vincristine results in decreased expression of SENP1 mRNA CTD PMID:23649840 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Septin6 septin 6 decreases expression ISO Vincristine results in decreased expression of SEPTIN6 mRNA CTD PMID:23649840 NCBI chr  X:36,174,925...36,253,711
Ensembl chr  X:36,174,979...36,255,447
JBrowse link
G Serinc5 serine incorporator 5 increases expression ISO Vincristine results in increased expression of SERINC5 mRNA CTD PMID:23649840 NCBI chr13:92,747,646...92,848,455
Ensembl chr13:92,747,599...92,848,455
JBrowse link
G Serpinb10 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 increases expression ISO Vincristine results in increased expression of SERPINB10 mRNA CTD PMID:23649840 NCBI chr 1:107,456,724...107,488,469
Ensembl chr 1:107,456,757...107,477,001
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 increases expression ISO Vincristine results in increased expression of SERPINB2 mRNA CTD PMID:23649840 NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208
JBrowse link
G Serpinb8 serine (or cysteine) peptidase inhibitor, clade B, member 8 increases expression ISO Vincristine results in increased expression of SERPINB8 mRNA CTD PMID:23649840 NCBI chr 1:107,517,668...107,536,708
Ensembl chr 1:107,517,736...107,538,214
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression
increases response to substance
ISO Vincristine results in increased expression of SERPINE1 mRNA
SERPINE1 gene SNP results in increased susceptibility to Vincristine
CTD PMID:20624997 PMID:21245421 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sertad3 SERTA domain containing 3 decreases expression ISO Vincristine results in decreased expression of SERTAD3 mRNA CTD PMID:23649840 NCBI chr 7:27,173,265...27,176,789
Ensembl chr 7:27,173,193...27,176,789
JBrowse link
G Sesn1 sestrin 1 increases expression ISO Vincristine results in increased expression of SESN1 mRNA CTD PMID:20624997 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Vincristine results in increased expression of SESN2 mRNA CTD PMID:23649840 NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812
JBrowse link
G Setbp1 SET binding protein 1 decreases expression ISO Vincristine results in decreased expression of SETBP1 mRNA CTD PMID:23649840 NCBI chr18:78,793,593...79,153,659
Ensembl chr18:78,793,595...79,152,606
JBrowse link
G Setd1b SET domain containing 1B decreases expression ISO Vincristine results in decreased expression of SETD1B mRNA CTD PMID:23649840 NCBI chr 5:123,280,109...123,306,693
Ensembl chr 5:123,280,256...123,306,692
JBrowse link
G Setd6 SET domain containing 6 decreases expression ISO Vincristine results in decreased expression of SETD6 mRNA CTD PMID:23649840 NCBI chr 8:96,442,211...96,448,135
Ensembl chr 8:96,442,509...96,445,638
JBrowse link
G Sfxn3 sideroflexin 3 increases expression ISO Vincristine results in increased expression of SFXN3 mRNA CTD PMID:23649840 NCBI chr19:45,036,015...45,044,822
Ensembl chr19:45,035,942...45,044,822
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Vincristine results in increased expression of SGK1 mRNA CTD PMID:23649840 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
JBrowse link
G Sh3yl1 Sh3 domain YSC-like 1 increases expression ISO Vincristine results in increased expression of SH3YL1 mRNA CTD PMID:23649840 NCBI chr12:30,961,622...31,010,159
Ensembl chr12:30,961,667...31,010,161
JBrowse link
G Shisa8 shisa family member 8 decreases expression ISO Vincristine results in decreased expression of SHISA8 mRNA CTD PMID:23649840 NCBI chr15:82,091,153...82,097,004
Ensembl chr15:82,090,369...82,097,016
JBrowse link
G Siah1a siah E3 ubiquitin protein ligase 1A decreases expression ISO Vincristine results in decreased expression of SIAH1 mRNA CTD PMID:23649840 NCBI chr 8:87,442,450...87,472,634
Ensembl chr 8:87,450,635...87,472,562
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Vincristine results in increased expression of SIAH2 mRNA CTD PMID:23649840 NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821
JBrowse link
G Sidt2 SID1 transmembrane family, member 2 increases expression ISO Vincristine results in increased expression of SIDT2 mRNA CTD PMID:23649840 NCBI chr 9:45,849,155...45,869,299
Ensembl chr 9:45,849,155...45,866,556
JBrowse link
G Sirpb1a signal-regulatory protein beta 1A decreases expression ISO Vincristine results in decreased expression of SIRPB1 mRNA CTD PMID:23649840 NCBI chr 3:15,436,887...15,491,487
Ensembl chr 3:15,436,713...15,491,580
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [Vincristine results in decreased expression of SIRT1 protein] CTD PMID:36808657 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO Vincristine results in decreased expression of SIVA1 mRNA CTD PMID:23649840 NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583
JBrowse link
G Six1 sine oculis-related homeobox 1 decreases expression ISO Vincristine results in decreased expression of SIX1 mRNA CTD PMID:23649840 NCBI chr12:73,088,601...73,093,486
Ensembl chr12:73,086,789...73,100,661
JBrowse link
G Skil SKI-like increases expression ISO Vincristine results in increased expression of SKIL mRNA CTD PMID:23649840 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726
JBrowse link
G Skp2 S-phase kinase-associated protein 2 decreases expression ISO Vincristine results in decreased expression of SKP2 mRNA CTD PMID:23649840 NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 increases expression ISO Vincristine results in increased expression of SLAMF1 mRNA CTD PMID:23649840 NCBI chr 1:171,594,700...171,628,752
Ensembl chr 1:171,594,695...171,628,752
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Vincristine results in increased expression of SLAMF7 mRNA CTD PMID:23649840 NCBI chr 1:171,458,506...171,480,522
Ensembl chr 1:171,459,971...171,480,603
JBrowse link
G Slc10a2 solute carrier family 10, member 2 increases response to substance ISO SLC10A2 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr 8:5,133,219...5,155,287
Ensembl chr 8:5,133,219...5,155,351
JBrowse link
G Slc15a4 solute carrier family 15, member 4 decreases expression ISO Vincristine results in decreased expression of SLC15A4 mRNA CTD PMID:23649840 NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961
JBrowse link
G Slc16a14 solute carrier family 16 (monocarboxylic acid transporters), member 14 decreases expression ISO Vincristine results in decreased expression of SLC16A14 mRNA CTD PMID:23649840 NCBI chr 1:84,881,344...84,912,927
Ensembl chr 1:84,883,619...84,912,855
JBrowse link
G Slc20a1 solute carrier family 20, member 1 decreases expression ISO Vincristine results in decreased expression of SLC20A1 mRNA CTD PMID:23649840 NCBI chr 2:129,038,662...129,053,535
Ensembl chr 2:129,040,684...129,053,536
JBrowse link
G Slc22a23 solute carrier family 22, member 23 increases expression ISO Vincristine results in increased expression of SLC22A23 mRNA CTD PMID:23649840 NCBI chr13:34,363,141...34,530,666
Ensembl chr13:34,363,141...34,529,165
JBrowse link
G Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 decreases expression ISO Vincristine results in decreased expression of SLC25A1 mRNA CTD PMID:23649840 NCBI chr16:17,743,075...17,746,083
Ensembl chr16:17,743,087...17,746,083
JBrowse link
G Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 decreases expression ISO Vincristine results in decreased expression of SLC25A11 mRNA CTD PMID:23649840 NCBI chr11:70,534,845...70,538,356
Ensembl chr11:70,535,022...70,538,305
JBrowse link
G Slc25a37 solute carrier family 25, member 37 decreases expression ISO Vincristine results in decreased expression of SLC25A37 mRNA CTD PMID:23649840 NCBI chr14:69,479,297...69,522,993
Ensembl chr14:69,479,297...69,522,561
JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 decreases expression ISO Vincristine results in decreased expression of SLC29A1 mRNA CTD PMID:23649840 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532
JBrowse link
G Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 decreases expression ISO Vincristine results in decreased expression of SLC29A2 mRNA CTD PMID:23649840 NCBI chr19:5,069,085...5,082,000
Ensembl chr19:5,073,888...5,082,000
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases response to substance ISO SLC2A1 protein results in decreased susceptibility to Vincristine CTD PMID:17520257 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Slc44a5 solute carrier family 44, member 5 increases expression ISO Vincristine results in increased expression of SLC44A5 mRNA CTD PMID:23649840 NCBI chr 3:153,679,056...153,977,384
Ensembl chr 3:153,679,073...153,977,359
JBrowse link
G Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 decreases expression ISO Vincristine results in decreased expression of SLC4A7 mRNA CTD PMID:23649840 NCBI chr14:7,669,819...7,766,808
Ensembl chr14:7,669,823...7,767,484
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Vincristine results in increased expression of SLC7A11 mRNA CTD PMID:23649840 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 increases expression ISO Vincristine results in increased expression of SLC9A9 mRNA CTD PMID:23649840 NCBI chr 9:94,551,945...95,112,505
Ensembl chr 9:94,551,962...95,112,498
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 decreases expression ISO Vincristine results in decreased expression of SLCO4C1 mRNA CTD PMID:23649840 NCBI chr 1:96,744,918...96,800,027
Ensembl chr 1:96,743,995...96,799,896
JBrowse link
G Smad1 SMAD family member 1 increases expression ISO Vincristine results in increased expression of SMAD1 mRNA CTD PMID:23649840 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
JBrowse link
G Smad2 SMAD family member 2 decreases expression ISO Vincristine results in decreased expression of SMAD2 mRNA CTD PMID:23649840 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
JBrowse link
G Smad4 SMAD family member 4 increases expression ISO Vincristine results in increased expression of SMAD4 mRNA CTD PMID:23649840 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
JBrowse link
G Smc6 structural maintenance of chromosomes 6 decreases expression ISO Vincristine results in decreased expression of SMC6 mRNA CTD PMID:23649840 NCBI chr12:11,315,887...11,369,786
Ensembl chr12:11,315,887...11,369,786
JBrowse link
G Snapc3 small nuclear RNA activating complex, polypeptide 3 decreases expression ISO Vincristine results in decreased expression of SNAPC3 mRNA CTD PMID:23649840 NCBI chr 4:83,333,948...83,391,256
Ensembl chr 4:83,335,961...83,385,913
JBrowse link
G Snhg10 small nucleolar RNA host gene 10 decreases expression ISO Vincristine results in decreased expression of SNHG10 mRNA CTD PMID:23649840 NCBI chr12:104,996,876...104,998,538
Ensembl chr12:104,996,875...104,998,567
JBrowse link
G Snhg12 small nucleolar RNA host gene 12 decreases expression ISO Vincristine results in decreased expression of SNHG12 mRNA CTD PMID:23649840 NCBI chr 4:132,035,989...132,038,335
Ensembl chr 4:132,035,932...132,038,762
JBrowse link
G Snhg3 small nucleolar RNA host gene 3 decreases expression ISO Vincristine results in decreased expression of SNHG3 mRNA CTD PMID:23649840 NCBI chr 4:132,079,244...132,080,997
Ensembl chr 4:132,075,325...132,080,997
JBrowse link
G Snhg7 small nucleolar RNA host gene 7 increases expression ISO Vincristine results in increased expression of SNHG7 mRNA CTD PMID:23649840 NCBI chr 2:26,527,188...26,530,256
Ensembl chr 2:26,527,180...26,530,295
JBrowse link
G Snn stannin increases expression ISO Vincristine results in increased expression of SNN mRNA CTD PMID:23649840 NCBI chr16:10,884,162...10,892,849
Ensembl chr16:10,878,809...10,892,849
JBrowse link
G Snord104 small nucleolar RNA, C/D box 104 decreases expression ISO Vincristine results in decreased expression of SNORD104 mRNA CTD PMID:23649840 NCBI chr11:106,391,817...106,391,889
Ensembl chr11:106,391,819...106,391,888
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein 200 (U5) increases expression ISO Vincristine results in increased expression of SNRNP200 mRNA CTD PMID:23649840 NCBI chr 2:127,050,306...127,082,373
Ensembl chr 2:127,050,306...127,082,371
JBrowse link
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' increases expression ISO Vincristine results in increased expression of SNRPA1 mRNA CTD PMID:23649840 NCBI chr 7:65,710,084...65,724,335
Ensembl chr 7:65,708,751...65,724,335
JBrowse link
G Snrpn small nuclear ribonucleoprotein N decreases expression ISO Vincristine results in decreased expression of SNRPN mRNA CTD PMID:23649840 NCBI chr 7:59,632,243...60,099,925
Ensembl chr 7:59,632,243...59,789,967
JBrowse link
G Snu13 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) decreases expression ISO Vincristine results in decreased expression of SNU13 mRNA CTD PMID:23649840 NCBI chr15:81,925,546...81,931,799
Ensembl chr15:81,924,726...81,931,799
JBrowse link
G Snx11 sorting nexin 11 increases expression ISO Vincristine results in increased expression of SNX11 mRNA CTD PMID:23649840 NCBI chr11:96,658,372...96,668,538
Ensembl chr11:96,658,381...96,668,385
JBrowse link
G Snx25 sorting nexin 25 decreases expression ISO Vincristine results in decreased expression of SNX25 mRNA CTD PMID:23649840 NCBI chr 8:46,486,298...46,605,535
Ensembl chr 8:46,486,298...46,605,196
JBrowse link
G Snx4 sorting nexin 4 decreases expression ISO Vincristine results in decreased expression of SNX4 mRNA CTD PMID:23649840 NCBI chr16:33,071,826...33,119,932
Ensembl chr16:33,071,812...33,120,639
JBrowse link
G Snx5 sorting nexin 5 decreases expression ISO Vincristine results in decreased expression of SNX5 mRNA CTD PMID:23649840 NCBI chr 2:144,092,043...144,112,713
Ensembl chr 2:144,092,043...144,112,826
JBrowse link
G Sobp sine oculis binding protein decreases expression ISO Vincristine results in decreased expression of SOBP mRNA CTD PMID:23649840 NCBI chr10:42,878,484...43,059,144
Ensembl chr10:42,878,496...43,050,526
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Vincristine results in increased expression of SOCS3 mRNA CTD PMID:23649840 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Vincristine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA] CTD PMID:9852137 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Son Son DNA binding protein decreases expression ISO Vincristine results in decreased expression of SON mRNA CTD PMID:23649840 NCBI chr16:91,444,712...91,476,080
Ensembl chr16:91,444,394...91,476,109
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 increases expression ISO Vincristine results in increased expression of SOS1 mRNA CTD PMID:16001973 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882
JBrowse link
G Sp1 trans-acting transcription factor 1 decreases expression ISO Vincristine results in decreased expression of SP1 mRNA CTD PMID:23649840 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sp100 nuclear antigen Sp100 increases expression ISO Vincristine results in increased expression of SP100 mRNA CTD PMID:23649840 NCBI chr 1:85,577,683...85,637,719
Ensembl chr 1:85,577,709...85,637,719
JBrowse link
G Sp140 Sp140 nuclear body protein increases expression ISO Vincristine results in increased expression of SP140L mRNA CTD PMID:23649840 NCBI chr 1:85,515,212...85,572,761
Ensembl chr 1:85,528,099...85,572,758
JBrowse link
G Sp4 trans-acting transcription factor 4 decreases expression ISO Vincristine results in decreased expression of SP4 mRNA CTD PMID:23649840 NCBI chr12:118,195,421...118,265,211
Ensembl chr12:118,198,668...118,265,175
JBrowse link
G Spart spartin decreases expression ISO Vincristine results in decreased expression of SPART mRNA CTD PMID:23649840 NCBI chr 3:55,019,500...55,044,753
Ensembl chr 3:55,019,529...55,044,743
JBrowse link
G Spic Spi-C transcription factor (Spi-1/PU.1 related) increases expression ISO Vincristine results in increased expression of SPIC mRNA CTD PMID:23649840 NCBI chr10:88,511,131...88,518,885
Ensembl chr10:88,510,634...88,520,877
JBrowse link
G Spin4 spindlin family, member 4 decreases expression ISO Vincristine results in decreased expression of SPIN4 mRNA CTD PMID:23649840 NCBI chr  X:94,066,113...94,070,288
Ensembl chr  X:94,066,116...94,070,288
JBrowse link
G Spon1 spondin 1, (f-spondin) extracellular matrix protein increases expression ISO Vincristine results in increased expression of SPON1 mRNA CTD PMID:20624997 NCBI chr 7:113,365,235...113,642,610
Ensembl chr 7:113,365,235...113,642,605
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence increases expression ISO Vincristine results in increased expression of SPRED1 mRNA CTD PMID:23649840 NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 decreases expression ISO Vincristine results in decreased expression of SPRY1 mRNA CTD PMID:23649840 NCBI chr 3:37,694,096...37,698,748
Ensembl chr 3:37,694,096...37,698,747
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO [cotylenin A co-treated with Vincristine] results in increased degradation of SQSTM1 protein
Vincristine results in increased expression of SQSTM1 mRNA
CTD PMID:23649840 PMID:25672400 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Vincristine results in decreased expression of SREBF1 mRNA CTD PMID:23649840 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srek1 splicing regulatory glutamine/lysine-rich protein 1 decreases expression ISO Vincristine results in decreased expression of SREK1 mRNA CTD PMID:23649840 NCBI chr13:103,873,291...103,911,379
Ensembl chr13:103,875,856...103,911,116
JBrowse link
G Srgn serglycin increases expression ISO Vincristine results in increased expression of SRGN mRNA CTD PMID:23649840 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230
JBrowse link
G Sri sorcin decreases response to substance ISO SRI protein results in decreased susceptibility to Vincristine CTD PMID:18423116 NCBI chr 5:8,096,078...8,119,314
Ensembl chr 5:8,096,078...8,119,379
JBrowse link
G Srm spermidine synthase decreases expression ISO Vincristine results in decreased expression of SRM mRNA CTD PMID:23649840 NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450
JBrowse link
G Srsf3 serine and arginine-rich splicing factor 3 decreases expression ISO Vincristine results in decreased expression of SRSF3 mRNA CTD PMID:23649840 NCBI chr17:29,251,634...29,262,346
Ensembl chr17:29,251,602...29,262,347
JBrowse link
G Srsf7 serine and arginine-rich splicing factor 7 decreases expression ISO Vincristine results in decreased expression of SRSF7 mRNA CTD PMID:23649840 NCBI chr17:80,507,509...80,514,734
Ensembl chr17:80,507,509...80,514,736
JBrowse link
G Ssbp1 single-stranded DNA binding protein 1 decreases expression ISO Vincristine results in decreased expression of SSBP1 mRNA CTD PMID:23649840 NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Vincristine results in increased expression of SSTR2 mRNA CTD PMID:23649840 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854
JBrowse link
G Stag1 STAG1 cohesin complex component increases expression ISO Vincristine results in increased expression of STAG1 mRNA CTD PMID:23649840 NCBI chr 9:100,479,762...100,840,597
Ensembl chr 9:100,479,851...100,841,428
JBrowse link
G Stambpl1 STAM binding protein like 1 decreases expression ISO Vincristine results in decreased expression of STAMBPL1 mRNA CTD PMID:23649840 NCBI chr19:34,169,629...34,217,733
Ensembl chr19:34,169,629...34,217,733
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO Vincristine results in increased expression of STAT1 mRNA CTD PMID:16001973 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Vincristine results in increased expression of STAT3 protein] CTD PMID:36808657 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Vincristine results in decreased expression of STIP1 mRNA CTD PMID:23649840 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
JBrowse link
G Stk4 serine/threonine kinase 4 increases expression ISO Vincristine results in increased expression of STK4 mRNA CTD PMID:23649840 NCBI chr 2:163,916,033...163,997,444
Ensembl chr 2:163,912,242...163,997,444
JBrowse link
G Strip2 striatin interacting protein 2 decreases expression ISO Vincristine results in decreased expression of STRIP2 mRNA CTD PMID:23649840 NCBI chr 6:29,916,975...29,959,680
Ensembl chr 6:29,917,011...29,959,680
JBrowse link
G Sts steroid sulfatase decreases expression ISO Vincristine results in decreased expression of STS mRNA CTD PMID:23649840 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924
JBrowse link
G Stx12 syntaxin 12 increases expression ISO Vincristine results in increased expression of STX12 mRNA CTD PMID:23649840 NCBI chr 4:132,581,375...132,611,769
Ensembl chr 4:132,580,812...132,611,820
JBrowse link
G Sun2 Sad1 and UNC84 domain containing 2 increases expression ISO Vincristine results in increased expression of SUN2 mRNA CTD PMID:23649840 NCBI chr15:79,608,269...79,626,757
Ensembl chr15:79,608,271...79,626,737
JBrowse link
G Supt20 SPT20 SAGA complex component increases expression ISO Vincristine results in increased expression of SUPT20H mRNA CTD PMID:23649840 NCBI chr 3:54,600,181...54,636,184
Ensembl chr 3:54,600,228...54,636,187
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit increases expression ISO Vincristine results in increased expression of SUZ12 mRNA CTD PMID:23649840 NCBI chr11:79,883,932...79,924,949
Ensembl chr11:79,883,932...79,924,949
JBrowse link
G Syf2 SYF2 homolog, RNA splicing factor (S. cerevisiae) increases expression ISO Vincristine results in increased expression of SYF2 mRNA CTD PMID:23649840 NCBI chr 4:134,658,291...134,664,848
Ensembl chr 4:134,658,209...134,664,859
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Vincristine results in decreased expression of SYNCRIP mRNA CTD PMID:23649840 NCBI chr 9:88,331,417...88,364,645
Ensembl chr 9:88,329,062...88,364,627
JBrowse link
G Syne2 spectrin repeat containing, nuclear envelope 2 decreases expression ISO Vincristine results in decreased expression of SYNE2 mRNA CTD PMID:23649840 NCBI chr12:75,865,092...76,157,702
Ensembl chr12:75,864,908...76,157,700
JBrowse link
G Sypl2 synaptophysin like 2 increases expression ISO Vincristine results in increased expression of SYPL2 mRNA CTD PMID:23649840 NCBI chr 3:108,119,582...108,133,915
Ensembl chr 3:108,118,788...108,133,964
JBrowse link
G Sytl3 synaptotagmin-like 3 increases expression ISO Vincristine results in increased expression of SYTL3 mRNA CTD PMID:23649840 NCBI chr17:6,925,633...7,005,449
Ensembl chr17:6,926,492...7,005,443
JBrowse link
G Taf15 TATA-box binding protein associated factor 15 increases expression ISO Vincristine results in increased expression of TAF15 mRNA CTD PMID:23649840 NCBI chr11:83,363,897...83,397,569
Ensembl chr11:83,363,912...83,397,569
JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I, D decreases expression ISO Vincristine results in decreased expression of TAF1D mRNA CTD PMID:23649840 NCBI chr 9:15,217,485...15,228,293
Ensembl chr 9:15,217,510...15,228,287
JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like decreases expression ISO Vincristine results in decreased expression of TAF5L mRNA CTD PMID:23649840 NCBI chr 8:124,723,049...124,748,136
Ensembl chr 8:124,723,057...124,748,136
JBrowse link
G Tank TRAF family member-associated Nf-kappa B activator decreases expression
increases expression
ISO Vincristine results in decreased expression of TANK mRNA
Vincristine results in increased expression of TANK mRNA
CTD PMID:23649840 NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515
JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) increases expression ISO Vincristine results in increased expression of TAP1 mRNA CTD PMID:23649840 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199
JBrowse link
G Tasor2 transcription activation suppressor family member 2 increases expression ISO Vincristine results in increased expression of TASOR2 mRNA CTD PMID:23649840 NCBI chr13:3,615,905...3,661,108
Ensembl chr13:3,616,035...3,661,108
JBrowse link
G Tbc1d12 TBC1D12: TBC1 domain family, member 12 decreases expression ISO Vincristine results in decreased expression of TBC1D12 mRNA CTD PMID:23649840 NCBI chr19:38,825,035...38,908,103
Ensembl chr19:38,825,023...38,908,367
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 increases expression ISO Vincristine results in increased expression of TBC1D4 mRNA CTD PMID:23649840 NCBI chr14:101,679,800...101,846,717
Ensembl chr14:101,679,796...101,846,627
JBrowse link
G Tbc1d8b TBC1 domain family, member 8B decreases expression ISO Vincristine results in decreased expression of TBC1D8B mRNA CTD PMID:23649840 NCBI chr  X:138,585,730...138,654,970
Ensembl chr  X:138,585,745...138,654,154
JBrowse link
G Tbx22 T-box 22 increases expression ISO Vincristine results in increased expression of TBX22 mRNA CTD PMID:23649840 NCBI chr  X:106,711,570...106,732,586
Ensembl chr  X:106,711,570...106,732,584
JBrowse link
G Tcaf1 TRPM8 channel-associated factor 1 decreases expression ISO Vincristine results in decreased expression of TCAF1 mRNA CTD PMID:23649840 NCBI chr 6:42,644,933...42,687,065
Ensembl chr 6:42,644,936...42,687,022
JBrowse link
G Tcea2 transcription elongation factor A (SII), 2 increases expression ISO Vincristine results in increased expression of TCEA2 mRNA CTD PMID:23649840 NCBI chr 2:181,322,090...181,329,860
Ensembl chr 2:181,322,103...181,329,864
JBrowse link
G Tcf19 transcription factor 19 decreases expression ISO Vincristine results in decreased expression of TCF19 mRNA CTD PMID:23649840 NCBI chr17:35,823,627...35,827,730
Ensembl chr17:35,823,631...35,827,721
JBrowse link
G Tcirg1 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 decreases expression ISO Vincristine results in decreased expression of TCIRG1 mRNA CTD PMID:23649840 NCBI chr19:3,946,050...3,957,717
Ensembl chr19:3,946,050...3,957,133
JBrowse link
G Tdrd9 tudor domain containing 9 increases expression ISO Vincristine results in increased expression of TDRD9 mRNA CTD PMID:23649840 NCBI chr12:111,937,922...112,035,288
Ensembl chr12:111,937,993...112,035,288
JBrowse link
G Tenm2 teneurin transmembrane protein 2 increases expression ISO Vincristine results in increased expression of TENM2 mRNA CTD PMID:23649840 NCBI chr11:35,897,483...37,881,486
Ensembl chr11:35,897,483...37,126,791
JBrowse link
G Tent2 terminal nucleotidyltransferase 2 increases expression ISO Vincristine results in increased expression of TENT2 mRNA CTD PMID:23649840 NCBI chr13:93,282,363...93,330,662
Ensembl chr13:93,282,790...93,328,893
JBrowse link
G Tent5c terminal nucleotidyltransferase 5C decreases expression ISO Vincristine results in decreased expression of TENT5C mRNA CTD PMID:23649840 NCBI chr 3:100,375,373...100,396,508
Ensembl chr 3:100,358,944...100,396,640
JBrowse link
G Tfap2a transcription factor AP-2, alpha decreases expression ISO Vincristine results in decreased expression of TFAP2A mRNA CTD PMID:23649840 NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO Vincristine results in increased expression of TFPI mRNA CTD PMID:23649840 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119
JBrowse link
G Tgds TDP-glucose 4,6-dehydratase increases expression ISO Vincristine results in increased expression of TGDS mRNA CTD PMID:23649840 NCBI chr14:118,349,323...118,370,177
Ensembl chr14:118,349,323...118,370,167
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases response to substance ISO TGFBI mRNA results in decreased susceptibility to Vincristine CTD PMID:25199881 NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375
JBrowse link
G Tgfbr3 transforming growth factor, beta receptor III decreases expression ISO Vincristine results in decreased expression of TGFBR3 mRNA CTD PMID:23649840 NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495
JBrowse link
G Thada thyroid adenoma associated increases expression ISO Vincristine results in increased expression of THADA mRNA CTD PMID:23649840 NCBI chr17:84,497,484...84,773,674
Ensembl chr17:84,497,504...84,773,633
JBrowse link
G Thbd thrombomodulin decreases response to substance ISO THBD protein results in decreased susceptibility to Vincristine CTD PMID:27474498 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Vincristine results in increased expression of THBS1 mRNA CTD PMID:20624997 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Them6 thioesterase superfamily member 6 decreases expression ISO Vincristine results in decreased expression of THEM6 mRNA CTD PMID:23649840 NCBI chr15:74,593,083...74,596,222
Ensembl chr15:74,593,053...74,596,488
JBrowse link
G Themis2 thymocyte selection associated family member 2 increases expression ISO Vincristine results in increased expression of THEMIS2 mRNA CTD PMID:23649840 NCBI chr 4:132,509,148...132,523,675
Ensembl chr 4:132,509,154...132,523,698
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Vincristine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
JBrowse link
G Tigar Trp53 induced glycolysis regulatory phosphatase increases expression ISO Vincristine results in increased expression of TIGAR mRNA CTD PMID:23649840 NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Vincristine results in increased expression of TIMP1 mRNA CTD PMID:20624997 PMID:23649840 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tinag tubulointerstitial nephritis antigen decreases expression ISO Vincristine results in decreased expression of TINAG mRNA CTD PMID:23649840 NCBI chr 9:76,858,980...76,953,084
Ensembl chr 9:76,858,975...76,953,076
JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein decreases expression ISO Vincristine results in decreased expression of TIRAP mRNA CTD PMID:23649840 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
JBrowse link
G Tlcd1 TLC domain containing 1 decreases expression ISO Vincristine results in decreased expression of TLCD1 mRNA CTD PMID:23649840 NCBI chr11:78,068,956...78,071,646
Ensembl chr11:78,067,537...78,072,735
JBrowse link
G Tm2d1 TM2 domain containing 1 decreases expression ISO Vincristine results in decreased expression of TM2D1 mRNA CTD PMID:23649840 NCBI chr 4:98,243,607...98,271,523
Ensembl chr 4:98,243,607...98,271,543
JBrowse link
G Tmcc3 transmembrane and coiled coil domains 3 increases expression ISO Vincristine results in increased expression of TMCC3 mRNA CTD PMID:23649840 NCBI chr10:94,147,544...94,426,816
Ensembl chr10:94,147,811...94,426,818
JBrowse link
G Tmco6 transmembrane and coiled-coil domains 6 decreases expression ISO Vincristine results in decreased expression of TMCO6 mRNA CTD PMID:23649840 NCBI chr18:36,868,072...36,875,453
Ensembl chr18:36,868,092...36,875,450
JBrowse link
G Tmem106c transmembrane protein 106C decreases expression ISO Vincristine results in decreased expression of TMEM106C mRNA CTD PMID:23649840 NCBI chr15:97,862,077...97,868,158
Ensembl chr15:97,862,081...97,868,156
JBrowse link
G Tmem107 transmembrane protein 107 decreases expression ISO Vincristine results in decreased expression of TMEM107 mRNA CTD PMID:23649840 NCBI chr11:68,961,635...68,964,119
Ensembl chr11:68,961,632...68,964,119
JBrowse link
G Tmem163 transmembrane protein 163 increases expression ISO Vincristine results in increased expression of TMEM163 mRNA CTD PMID:23649840 NCBI chr 1:127,418,079...127,605,758
Ensembl chr 1:127,414,283...127,607,285
JBrowse link
G Tmem177 transmembrane protein 177 decreases expression ISO Vincristine results in decreased expression of TMEM177 mRNA CTD PMID:23649840 NCBI chr 1:119,835,620...119,840,913
Ensembl chr 1:119,835,620...119,840,938
JBrowse link
G Tmem200a transmembrane protein 200A decreases expression ISO Vincristine results in decreased expression of TMEM200A mRNA CTD PMID:23649840 NCBI chr10:25,867,080...25,955,713
Ensembl chr10:25,788,229...25,954,950
JBrowse link
G Tmem223 transmembrane protein 223 decreases expression ISO Vincristine results in decreased expression of TMEM223 mRNA CTD PMID:23649840 NCBI chr19:8,748,360...8,749,839
Ensembl chr19:8,748,360...8,749,839
JBrowse link
G Tmem267 transmembrane protein 267 increases expression ISO Vincristine results in increased expression of TMEM267 mRNA CTD PMID:23649840 NCBI chr13:119,624,622...120,071,995
Ensembl chr13:119,624,575...120,072,595
JBrowse link
G Tmem38a transmembrane protein 38A decreases expression ISO Vincristine results in decreased expression of TMEM38A mRNA CTD PMID:23649840 NCBI chr 8:73,325,033...73,341,128
Ensembl chr 8:73,325,899...73,341,126
JBrowse link
G Tmem43 transmembrane protein 43 increases expression ISO Vincristine results in increased expression of TMEM43 mRNA CTD PMID:23649840 NCBI chr 6:91,450,689...91,465,445
Ensembl chr 6:91,450,685...91,465,445
JBrowse link
G Tmem80 transmembrane protein 80 decreases expression ISO Vincristine results in decreased expression of TMEM80 mRNA CTD PMID:23649840 NCBI chr 7:140,908,046...140,917,069
Ensembl chr 7:140,907,652...140,917,069
JBrowse link
G Tmf1 TATA element modulatory factor 1 increases expression ISO Vincristine results in increased expression of TMF1 mRNA CTD PMID:23649840 NCBI chr 6:97,128,911...97,156,107
Ensembl chr 6:97,129,958...97,156,083
JBrowse link
G Tmx4 thioredoxin-related transmembrane protein 4 decreases expression ISO Vincristine results in decreased expression of TMX4 mRNA CTD PMID:23649840 NCBI chr 2:134,436,421...134,486,041
Ensembl chr 2:134,436,105...134,486,065
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein]; Pregabalin inhibits the reaction [Vincristine results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of TNF mRNA]; tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
KN 93 inhibits the reaction [Vincristine results in increased expression of TNF mRNA]
Vincristine results in increased expression of TNF mRNA; Vincristine results in increased expression of TNF protein
CTD PMID:23649840 PMID:24374478 PMID:26102012 PMID:29958920 PMID:34286406 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 increases expression ISO Vincristine results in increased expression of TNFAIP3 mRNA CTD PMID:23649840 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 increases expression ISO Vincristine results in increased expression of TNFAIP6 mRNA CTD PMID:23649840 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
G Tnfaip8l1 tumor necrosis factor, alpha-induced protein 8-like 1 increases expression ISO Vincristine results in increased expression of TNFAIP8L1 mRNA CTD PMID:23649840 NCBI chr17:56,469,439...56,491,249
Ensembl chr17:56,469,477...56,480,955
JBrowse link
G Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 decreases expression ISO Vincristine results in decreased expression of TNFRSF17 mRNA CTD PMID:23649840 NCBI chr16:11,131,131...11,137,938
Ensembl chr16:11,131,676...11,137,938
JBrowse link
G Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 decreases expression ISO Vincristine results in decreased expression of TNFRSF19 mRNA CTD PMID:23649840 NCBI chr14:61,201,283...61,284,304
Ensembl chr14:61,201,324...61,283,939
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 increases expression ISO Vincristine results in increased expression of TNFRSF9 mRNA CTD PMID:23649840 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases expression ISO Vincristine results in increased expression of TNFSF10 mRNA CTD PMID:23649840 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 increases expression ISO Vincristine results in increased expression of TNFSF4 mRNA CTD PMID:23649840 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981
JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 increases expression ISO Vincristine results in increased expression of TNFSF9 mRNA CTD PMID:23649840 NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 increases expression ISO Vincristine results in increased expression of TNIP2 mRNA CTD PMID:23649840 NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335
JBrowse link
G Tnni3 troponin I, cardiac 3 increases expression ISO Vincristine results in increased expression of TNNI3 protein CTD PMID:20624997 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228
JBrowse link
G Tnnt2 troponin T2, cardiac multiple interactions ISO Vincristine inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein] CTD PMID:25537132 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998
JBrowse link
G Tomm70a translocase of outer mitochondrial membrane 70A decreases expression ISO Vincristine results in decreased expression of TOMM70 mRNA CTD PMID:23649840 NCBI chr16:56,942,077...56,974,893
Ensembl chr16:56,942,066...56,977,068
JBrowse link
G Top2a topoisomerase (DNA) II alpha decreases expression ISO Vincristine results in decreased expression of TOP2A mRNA CTD PMID:23649840 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
JBrowse link
G Topbp1 topoisomerase (DNA) II binding protein 1 decreases expression ISO Vincristine results in decreased expression of TOPBP1 mRNA CTD PMID:23649840 NCBI chr 9:103,182,351...103,227,627
Ensembl chr 9:103,182,414...103,227,627
JBrowse link
G Tpcn2 two pore segment channel 2 increases expression ISO Vincristine results in increased expression of TPCN2 mRNA CTD PMID:23649840 NCBI chr 7:144,735,370...144,837,743
Ensembl chr 7:144,740,261...144,837,748
JBrowse link
G Tpd52 tumor protein D52 decreases expression ISO Vincristine results in decreased expression of TPD52 mRNA CTD PMID:23649840 NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783
JBrowse link
G Tpd52l1 tumor protein D52-like 1 increases expression ISO Vincristine results in increased expression of TPD52L1 mRNA CTD PMID:20624997 NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects response to substance ISO TPI1 protein affects the susceptibility to Vincristine CTD PMID:18309519 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO Vincristine results in increased expression of TPM4 mRNA CTD PMID:23649840 NCBI chr 8:72,889,132...72,906,986
Ensembl chr 8:72,884,018...72,906,986
JBrowse link
G Tprg1l transformation related protein 63 regulated 1 like increases expression ISO Vincristine results in increased expression of TPRG1L mRNA CTD PMID:23649840 NCBI chr 4:154,241,942...154,246,763
Ensembl chr 4:154,241,942...154,245,123
JBrowse link
G Tra2a transformer 2 alpha increases expression ISO Vincristine results in increased expression of TRA2A mRNA CTD PMID:23649840 NCBI chr 6:49,220,855...49,241,182
Ensembl chr 6:49,220,858...49,240,967
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Vincristine results in increased expression of TRAF1 mRNA CTD PMID:23649840 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 decreases expression ISO Vincristine results in decreased expression of TRAF3IP3 mRNA CTD PMID:23649840 NCBI chr 1:192,857,812...192,883,854
Ensembl chr 1:192,857,761...192,884,011
JBrowse link
G Trappc10 trafficking protein particle complex 10 increases expression ISO Vincristine results in increased expression of TRAPPC10 mRNA CTD PMID:23649840 NCBI chr10:78,021,256...78,080,479
Ensembl chr10:78,022,559...78,080,475
JBrowse link
G Trex1 three prime repair exonuclease 1 decreases expression ISO Vincristine results in decreased expression of TREX1 mRNA CTD PMID:23649840 NCBI chr 9:108,887,000...108,888,791
Ensembl chr 9:108,887,001...108,888,802
JBrowse link
G Trib1 tribbles pseudokinase 1 decreases expression ISO Vincristine results in decreased expression of TRIB1 mRNA CTD PMID:23649840 NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948
JBrowse link
G Trim13 tripartite motif-containing 13 decreases expression ISO Vincristine results in decreased expression of TRIM13 mRNA CTD PMID:23649840 NCBI chr14:61,835,675...61,847,736
Ensembl chr14:61,835,696...61,843,395
JBrowse link
G Trim29 tripartite motif-containing 29 increases expression ISO Vincristine results in increased expression of TRIM29 mRNA CTD PMID:23649840 NCBI chr 9:43,222,012...43,247,422
Ensembl chr 9:43,222,145...43,247,412
JBrowse link
G Trim30a tripartite motif-containing 30A increases expression ISO Vincristine results in increased expression of TRIM22 mRNA CTD PMID:23649840 NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400
JBrowse link
G Trim45 tripartite motif-containing 45 decreases expression ISO Vincristine results in decreased expression of TRIM45 mRNA CTD PMID:23649840 NCBI chr 3:100,828,516...100,844,241
Ensembl chr 3:100,829,518...100,844,236
JBrowse link
G Trio triple functional domain (PTPRF interacting) increases expression ISO Vincristine results in increased expression of TRIO mRNA CTD PMID:23649840 NCBI chr15:27,730,735...28,025,954
Ensembl chr15:27,730,737...28,025,934
JBrowse link
G Trir telomerase RNA component interacting RNase decreases expression ISO Vincristine results in decreased expression of TRIR mRNA CTD PMID:23649840 NCBI chr 8:85,753,440...85,756,920
Ensembl chr 8:85,753,452...85,756,915
JBrowse link
G Trp53 transformation related protein 53 increases response to substance
increases glutathionylation
increases expression
multiple interactions
increases activity
ISO TP53 protein results in increased susceptibility to Vincristine
Vincristine results in increased glutathionylation of TP53 protein
Vincristine results in increased expression of TP53 protein
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of TP53 protein
Vincristine results in increased activity of TP53 protein
CTD PMID:9815696 PMID:12082016 PMID:14704126 PMID:15131059 PMID:17555331 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 increases expression ISO Vincristine results in increased expression of TP53INP1 mRNA CTD PMID:23649840 NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Vincristine results in increased expression of TRPV2 mRNA CTD PMID:23649840 NCBI chr11:62,465,312...62,491,131
Ensembl chr11:62,465,312...62,491,341
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases response to substance ISO TRPV4 protein results in increased susceptibility to Vincristine CTD PMID:18234883 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Vincristine results in decreased expression of TSC22D1 mRNA CTD PMID:23649840 NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
JBrowse link
G Tsen15 tRNA splicing endonuclease subunit 15 decreases expression ISO Vincristine results in decreased expression of TSEN15 mRNA CTD PMID:23649840 NCBI chr 1:152,246,486...152,262,433
Ensembl chr 1:152,246,486...152,262,439
JBrowse link
G Tsg101 tumor susceptibility gene 101 affects response to substance ISO TSG101 affects the susceptibility to Vincristine CTD PMID:15044860 NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717
JBrowse link
G Tshz1 teashirt zinc finger family member 1 decreases expression ISO Vincristine results in decreased expression of TSHZ1 mRNA CTD PMID:23649840 NCBI chr18:84,029,752...84,105,833
Ensembl chr18:84,029,752...84,105,831
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 decreases expression ISO Vincristine results in decreased expression of TTC3 mRNA CTD PMID:23649840 NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202
JBrowse link
G Ttc9c tetratricopeptide repeat domain 9C increases expression
decreases expression
ISO Vincristine results in increased expression of TTC9C mRNA
Vincristine results in decreased expression of TTC9C mRNA
CTD PMID:23649840 NCBI chr19:8,786,430...8,797,270
Ensembl chr19:8,786,439...8,796,697
JBrowse link
G Ttyh2 tweety family member 2 increases expression ISO Vincristine results in increased expression of TTYH2 mRNA CTD PMID:23649840 NCBI chr11:114,566,294...114,611,810
Ensembl chr11:114,566,257...114,611,803
JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression ISO Vincristine results in decreased expression of TUBA1B mRNA CTD PMID:20624997 PMID:23649840 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression ISO Vincristine results in decreased expression of TUBA1C mRNA CTD PMID:23649840 NCBI chr15:98,927,772...98,935,986
Ensembl chr15:98,927,772...98,935,991
JBrowse link
G Tuba3a tubulin, alpha 3A decreases expression ISO Vincristine results in decreased expression of TUBA3C mRNA CTD PMID:23649840 NCBI chr 6:125,255,233...125,263,044
Ensembl chr 6:125,255,237...125,263,005
JBrowse link
G Tuba3b tubulin, alpha 3B decreases expression ISO Vincristine results in decreased expression of TUBA3D mRNA CTD PMID:23649840 NCBI chr 6:145,561,689...145,567,203
Ensembl chr 6:145,561,483...145,567,205
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Vincristine results in decreased expression of TUBA4A mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Vincristine results in decreased expression of TUBB3 mRNA CTD PMID:23649840 NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754
JBrowse link
G Tubb4b tubulin, beta 4B class IVB decreases expression ISO Vincristine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Vincristine results in decreased expression of TUBB mRNA
Vincristine results in decreased expression of TUBB5 mRNA
CTD PMID:20624997 PMID:23649840 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tubg1 tubulin, gamma 1 decreases expression ISO Vincristine results in decreased expression of TUBG1 mRNA CTD PMID:20624997 PMID:23649840 NCBI chr11:101,010,725...101,017,249
Ensembl chr11:101,010,764...101,017,245
JBrowse link
G Tubgcp5 tubulin, gamma complex component 5 decreases expression ISO Vincristine results in decreased expression of TUBGCP5 mRNA CTD PMID:23649840 NCBI chr 7:55,443,873...55,481,207
Ensembl chr 7:55,443,902...55,481,425
JBrowse link
G Tulp4 TUB like protein 4 increases expression ISO Vincristine results in increased expression of TULP4 mRNA CTD PMID:23649840 NCBI chr17:6,156,528...6,290,912
Ensembl chr17:6,156,712...6,301,403
JBrowse link
G Twf1 twinfilin actin binding protein 1 affects response to substance EXP TWF1 protein affects the susceptibility to Vincristine CTD PMID:19783987 NCBI chr15:94,475,829...94,487,727
Ensembl chr15:94,475,832...94,487,770
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Vincristine results in increased expression of TXNIP mRNA CTD PMID:23649840 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO TYMP inhibits the reaction [Vincristine results in increased phosphorylation of BCL2 protein] CTD PMID:15907805 NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242
JBrowse link
G Tyms thymidylate synthase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Vincristine CTD PMID:15713801 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases expression ISO Vincristine results in increased expression of U2SURP mRNA CTD PMID:23649840 NCBI chr 9:95,338,947...95,394,049
Ensembl chr 9:95,338,951...95,394,049
JBrowse link
G Ubald2 UBA-like domain containing 2 increases expression ISO Vincristine results in increased expression of UBALD2 mRNA CTD PMID:23649840 NCBI chr11:116,324,920...116,329,903
Ensembl chr11:116,324,920...116,329,903
JBrowse link
G Ubap2 ubiquitin-associated protein 2 decreases expression ISO Vincristine results in decreased expression of UBAP2 mRNA CTD PMID:23649840 NCBI chr 4:41,194,313...41,276,016
Ensembl chr 4:41,194,313...41,275,144
JBrowse link
G Ubc ubiquitin C decreases expression ISO Vincristine results in decreased expression of UBC mRNA CTD PMID:23649840 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Vincristine results in decreased expression of UBE2C mRNA CTD PMID:23649840 NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 decreases expression ISO Vincristine results in decreased expression of UBE2G1 mRNA CTD PMID:23649840 NCBI chr11:72,498,087...72,577,307
Ensembl chr11:72,498,109...72,577,307
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Vincristine results in decreased expression of UBE2I mRNA CTD PMID:23649840 NCBI chr17:25,479,484...25,494,965
Ensembl chr17:25,479,482...25,493,856
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2J 1 decreases expression ISO Vincristine results in decreased expression of UBE2J1 mRNA CTD PMID:23649840 NCBI chr 4:33,031,380...33,052,367
Ensembl chr 4:33,031,416...33,052,363
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 increases expression ISO Vincristine results in increased expression of UBR2 mRNA CTD PMID:23649840 NCBI chr17:47,239,217...47,321,812
Ensembl chr17:47,239,221...47,321,482
JBrowse link
G Ubr4 ubiquitin protein ligase E3 component n-recognin 4 increases expression ISO Vincristine results in increased expression of UBR4 mRNA CTD PMID:23649840 NCBI chr 4:139,107,970...139,216,844
Ensembl chr 4:139,079,920...139,216,899
JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 increases expression ISO Vincristine results in increased expression of UCHL1 protein CTD PMID:16797537 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) decreases expression ISO Vincristine results in decreased expression of UCP2 mRNA CTD PMID:23649840 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO Vincristine results in increased expression of UGCG mRNA CTD PMID:23649840 NCBI chr 4:59,189,452...59,222,833
Ensembl chr 4:59,189,257...59,222,833
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Vincristine results in increased expression of UGGT2 mRNA CTD PMID:23649840 NCBI chr14:119,219,177...119,337,208
Ensembl chr14:119,222,451...119,336,842
JBrowse link
G Unc119 unc-119 lipid binding chaperone increases expression ISO Vincristine results in increased expression of UNC119 mRNA CTD PMID:23649840 NCBI chr11:78,234,321...78,239,990
Ensembl chr11:78,234,308...78,239,990
JBrowse link
G Upb1 ureidopropionase, beta increases expression ISO Vincristine results in increased expression of UPB1 mRNA CTD PMID:23649840 NCBI chr10:75,242,745...75,277,513
Ensembl chr10:75,236,949...75,277,513
JBrowse link
G Urod uroporphyrinogen decarboxylase decreases expression ISO Vincristine results in decreased expression of UROD mRNA CTD PMID:23649840 NCBI chr 4:116,847,161...116,851,561
Ensembl chr 4:116,847,162...116,851,610
JBrowse link
G Usp12 ubiquitin specific peptidase 12 increases expression ISO Vincristine results in increased expression of USP12 mRNA CTD PMID:23649840 NCBI chr 5:146,671,619...146,731,817
Ensembl chr 5:146,671,619...146,731,816
JBrowse link
G Usp25 ubiquitin specific peptidase 25 decreases expression ISO Vincristine results in decreased expression of USP25 mRNA CTD PMID:23649840 NCBI chr16:76,810,573...76,913,671
Ensembl chr16:76,810,594...76,913,668
JBrowse link
G Usp34 ubiquitin specific peptidase 34 increases expression ISO Vincristine results in increased expression of USP34 mRNA CTD PMID:23649840 NCBI chr11:23,256,433...23,440,560
Ensembl chr11:23,256,895...23,440,560
JBrowse link
G Usp37 ubiquitin specific peptidase 37 decreases expression ISO Vincristine results in decreased expression of USP37 mRNA CTD PMID:23649840 NCBI chr 1:74,474,669...74,583,447
Ensembl chr 1:74,474,670...74,583,443
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 decreases expression ISO Vincristine results in decreased expression of VAMP2 mRNA CTD PMID:23649840 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases expression ISO Vincristine results in increased expression of VASP mRNA CTD PMID:23649840 NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Vincristine results in increased expression of VCAM1 mRNA CTD PMID:20624997 PMID:23649840 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor affects response to substance ISO VDR gene polymorphism affects the susceptibility to Vincristine CTD PMID:15713801 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Vincristine results in decreased expression of VEGFA mRNA CTD PMID:20624997 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vezf1 vascular endothelial zinc finger 1 decreases expression ISO Vincristine results in decreased expression of VEZF1 mRNA CTD PMID:23649840 NCBI chr11:87,959,084...87,975,555
Ensembl chr11:87,959,105...87,975,555
JBrowse link
G Vit vitrin increases response to substance ISO VIT mRNA results in increased susceptibility to Vincristine CTD PMID:25199881 NCBI chr17:78,815,480...78,934,838
Ensembl chr17:78,815,493...78,934,837
JBrowse link
G Vps13a vacuolar protein sorting 13A decreases expression ISO Vincristine results in decreased expression of VPS13A mRNA CTD PMID:23649840 NCBI chr19:16,592,730...16,758,433
Ensembl chr19:16,592,730...16,758,297
JBrowse link
G Vps13d vacuolar protein sorting 13D increases expression ISO Vincristine results in increased expression of VPS13D mRNA CTD PMID:23649840 NCBI chr 4:144,597,619...144,921,598
Ensembl chr 4:144,699,192...144,921,575
JBrowse link
G Vps25 vacuolar protein sorting 25 decreases expression ISO Vincristine results in decreased expression of VPS25 mRNA CTD PMID:23649840 NCBI chr11:101,144,533...101,150,377
Ensembl chr11:101,144,533...101,150,375
JBrowse link
G Vps53 VPS53 GARP complex subunit increases expression ISO Vincristine results in increased expression of VPS53 mRNA CTD PMID:23649840 NCBI chr11:75,937,052...76,070,464
Ensembl chr11:75,937,052...76,070,473
JBrowse link
G Vps72 vacuolar protein sorting 72 decreases expression ISO Vincristine results in decreased expression of VPS72 mRNA CTD PMID:23649840 NCBI chr 3:95,018,353...95,030,362
Ensembl chr 3:95,018,333...95,030,362
JBrowse link
G Vti1a vesicle transport through interaction with t-SNAREs 1A decreases expression ISO Vincristine results in decreased expression of VTI1A mRNA CTD PMID:23649840 NCBI chr19:55,304,489...55,615,893
Ensembl chr19:55,304,727...55,615,741
JBrowse link
G Vwf Von Willebrand factor increases expression ISO Vincristine results in increased expression of VWF mRNA CTD PMID:20624997 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642
JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 decreases expression ISO Vincristine results in decreased expression of WDHD1 mRNA CTD PMID:23649840 NCBI chr14:47,478,401...47,514,352
Ensembl chr14:47,478,401...47,514,314
JBrowse link
G Wdr17 WD repeat domain 17 decreases expression ISO Vincristine results in decreased expression of WDR17 mRNA CTD PMID:23649840 NCBI chr 8:55,082,316...55,180,014
Ensembl chr 8:55,082,090...55,340,219
JBrowse link
G Wdr33 WD repeat domain 33 decreases expression ISO Vincristine results in decreased expression of WDR33 mRNA CTD PMID:23649840 NCBI chr18:31,937,079...32,042,040
Ensembl chr18:31,937,143...32,040,450
JBrowse link
G Wdr72 WD repeat domain 72 decreases expression ISO Vincristine results in decreased expression of WDR72 mRNA CTD PMID:23649840 NCBI chr 9:74,017,608...74,190,485
Ensembl chr 9:74,017,638...74,190,590
JBrowse link
G Wdr76 WD repeat domain 76 decreases expression ISO Vincristine results in decreased expression of WDR76 mRNA CTD PMID:23649840 NCBI chr 2:121,337,204...121,375,341
Ensembl chr 2:121,337,204...121,375,341
JBrowse link
G Wdr90 WD repeat domain 90 decreases expression ISO Vincristine results in decreased expression of WDR90 mRNA CTD PMID:23649840 NCBI chr17:26,063,708...26,080,489
Ensembl chr17:26,063,745...26,080,475
JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) decreases expression ISO Vincristine results in decreased expression of WEE1 mRNA CTD PMID:23649840 NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 increases expression ISO Vincristine results in increased expression of WNK1 mRNA CTD PMID:23649840 NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 decreases expression ISO Vincristine results in decreased expression of WSB1 mRNA CTD PMID:23649840 NCBI chr11:79,130,208...79,145,521
Ensembl chr11:79,130,198...79,145,497
JBrowse link
G Xirp2 xin actin-binding repeat containing 2 decreases expression ISO Vincristine results in decreased expression of XIRP2 mRNA CTD PMID:23649840 NCBI chr 2:67,276,343...67,356,964
Ensembl chr 2:67,004,178...67,356,959
JBrowse link
G Xpnpep3 X-prolyl aminopeptidase 3, mitochondrial increases expression ISO Vincristine results in increased expression of XPNPEP3 mRNA CTD PMID:23649840 NCBI chr15:81,284,282...81,341,683
Ensembl chr15:81,284,339...81,341,683
JBrowse link
G Ypel5 yippee like 5 increases expression ISO Vincristine results in increased expression of YPEL5 mRNA CTD PMID:23649840 NCBI chr17:73,143,623...73,157,439
Ensembl chr17:73,143,448...73,158,190
JBrowse link
G Ythdc2 YTH domain containing 2 decreases expression ISO Vincristine results in decreased expression of YTHDC2 mRNA CTD PMID:23649840 NCBI chr18:44,961,521...45,022,782
Ensembl chr18:44,960,813...45,022,791
JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein 3 increases expression ISO Vincristine results in increased expression of YTHDF3 mRNA CTD PMID:23649840 NCBI chr 3:16,237,309...16,271,201
Ensembl chr 3:16,237,376...16,271,201
JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 increases expression ISO Vincristine results in increased expression of ZBTB10 mRNA CTD PMID:23649840 NCBI chr 3:9,315,627...9,350,393
Ensembl chr 3:9,315,662...9,350,393
JBrowse link
G Zbtb14 zinc finger and BTB domain containing 14 decreases expression ISO Vincristine results in decreased expression of ZBTB14 mRNA CTD PMID:23649840 NCBI chr17:69,690,170...69,697,747
Ensembl chr17:69,690,045...69,698,194
JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Vincristine results in decreased expression of ZBTB24 mRNA CTD PMID:23649840 NCBI chr10:41,326,354...41,341,578
Ensembl chr10:41,326,379...41,341,570
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A increases expression ISO Vincristine results in increased expression of ZC3H12A mRNA CTD PMID:23649840 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633
JBrowse link
G Zcchc2 zinc finger, CCHC domain containing 2 decreases expression ISO Vincristine results in decreased expression of ZCCHC2 mRNA CTD PMID:23649840 NCBI chr 1:105,916,929...105,961,807
Ensembl chr 1:105,918,136...105,961,804
JBrowse link
G Zfas1 zinc finger, NFX1-type containing 1, antisense RNA 1 decreases expression ISO Vincristine results in decreased expression of ZFAS1 mRNA CTD PMID:23649840 NCBI chr 2:166,904,854...166,907,782
Ensembl chr 2:166,904,854...166,907,783
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression
increases expression
ISO Vincristine results in decreased expression of ZNF207 mRNA
Vincristine results in increased expression of ZNF207 mRNA
CTD PMID:23649840 NCBI chr11:80,274,105...80,299,387
Ensembl chr11:80,274,105...80,296,559
JBrowse link
G Zfp395 zinc finger protein 395 decreases expression ISO Vincristine results in decreased expression of ZNF395 mRNA CTD PMID:23649840 NCBI chr14:65,595,796...65,636,379
Ensembl chr14:65,595,838...65,636,379
JBrowse link
G Zfp503 zinc finger protein 503 decreases expression ISO Vincristine results in decreased expression of ZNF503 mRNA CTD PMID:23649840 NCBI chr14:22,034,030...22,039,669
Ensembl chr14:22,034,027...22,039,669
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO Vincristine results in increased expression of ZNF638 mRNA CTD PMID:23649840 NCBI chr 6:83,844,050...83,963,855
Ensembl chr 6:83,844,091...83,966,532
JBrowse link
G Zfp652 zinc finger protein 652 decreases expression ISO Vincristine results in decreased expression of ZNF652 mRNA CTD PMID:23649840 NCBI chr11:95,639,893...95,655,541
Ensembl chr11:95,603,499...95,725,941
JBrowse link
G Zfp672 zinc finger protein 672 decreases expression ISO Vincristine results in decreased expression of ZNF672 mRNA CTD PMID:23649840 NCBI chr11:58,205,940...58,221,197
Ensembl chr11:58,205,940...58,221,165
JBrowse link
G Zfp691 zinc finger protein 691 decreases expression ISO Vincristine results in decreased expression of ZNF691 mRNA CTD PMID:23649840 NCBI chr 4:119,026,710...119,031,429
Ensembl chr 4:119,026,710...119,031,392
JBrowse link
G Zfp692 zinc finger protein 692 decreases expression ISO Vincristine results in decreased expression of ZNF692 mRNA CTD PMID:23649840 NCBI chr11:58,197,883...58,205,971
Ensembl chr11:58,197,895...58,205,453
JBrowse link
G Zfp709 zinc finger protein 709 decreases expression ISO Vincristine results in decreased expression of ZNF443 mRNA CTD PMID:23649840 NCBI chr 8:72,635,912...72,646,409
Ensembl chr 8:72,635,863...72,649,571
JBrowse link
G Zfp830 zinc finger protein 830 decreases expression ISO Vincristine results in decreased expression of ZNF830 mRNA CTD PMID:23649840 NCBI chr11:82,655,171...82,658,448
Ensembl chr11:82,655,171...82,656,761
JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 increases expression ISO Vincristine results in increased expression of ZFYVE16 mRNA CTD PMID:23649840 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376
JBrowse link
G Zmat3 zinc finger matrin type 3 increases expression ISO Vincristine results in increased expression of ZMAT3 mRNA CTD PMID:23649840 NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163
JBrowse link
G Zmiz2 zinc finger, MIZ-type containing 2 increases expression ISO Vincristine results in increased expression of ZMIZ2 mRNA CTD PMID:23649840 NCBI chr11:6,339,063...6,356,158
Ensembl chr11:6,339,074...6,356,158
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO Vincristine results in increased expression of ZMYND8 mRNA CTD PMID:23649840 NCBI chr 2:165,626,072...165,740,896
Ensembl chr 2:165,626,072...165,740,936
JBrowse link
G Znfx1 zinc finger, NFX1-type containing 1 increases expression ISO Vincristine results in increased expression of ZNFX1 mRNA CTD PMID:23649840 NCBI chr 2:166,877,713...166,904,926
Ensembl chr 2:166,877,713...166,904,935
JBrowse link
G Znrf2 zinc and ring finger 2 decreases expression ISO Vincristine results in decreased expression of ZNRF2 mRNA CTD PMID:23649840 NCBI chr 6:54,793,901...54,867,209
Ensembl chr 6:54,793,901...54,870,485
JBrowse link
vindesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions
decreases expression
ISO Tamoxifen promotes the reaction [Vindesine results in decreased expression of BAX mRNA] CTD PMID:19757172 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
ISO Tamoxifen promotes the reaction [Vindesine results in increased expression of BCL2 mRNA] CTD PMID:19757172 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Ngf nerve growth factor decreases response to substance ISO Vindesine results in decreased susceptibility to NGF protein CTD PMID:9524088 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
vinorelbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO
EXP
[pifithrin co-treated with vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein
[Cisplatin co-treated with vinorelbine] results in increased activity of CASP3 protein
CTD PMID:18516295 PMID:21544650 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of CASP7 mRNA CTD PMID:21544650 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Cd40lg CD40 ligand multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA CTD PMID:21544650 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression ISO vinorelbine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
increases expression
ISO [vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein
vinorelbine results in increased expression of EPCAM protein
CTD PMID:12695858 NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in increased expression of FAS protein CTD PMID:21544650 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA CTD PMID:21544650 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA CTD PMID:21544650 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il7 interleukin 7 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein CTD PMID:21544650 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Krt18 keratin 18 increases expression
increases metabolic processing
ISO vinorelbine results in increased expression of KRT18 protein
vinorelbine results in increased metabolism of KRT18 protein
CTD PMID:16685278 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Lhx4 LIM homeobox protein 4 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of LHX4 mRNA CTD PMID:21544650 NCBI chr 1:155,573,777...155,627,481
Ensembl chr 1:155,573,777...155,627,430
JBrowse link
G Naip1 NLR family, apoptosis inhibitory protein 1 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of NAIP1 mRNA CTD PMID:21544650 NCBI chr13:100,544,272...100,589,372
Ensembl chr13:100,544,272...100,589,377
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to vinorelbine CTD PMID:24736981 NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 multiple interactions EXP [Cisplatin co-treated with Vinorelbine] results in decreased expression of PAK5 mRNA CTD PMID:21544650 NCBI chr 2:135,923,008...136,229,899
Ensembl chr 2:135,923,024...136,229,887
JBrowse link
G Proc protein C decreases expression ISO vinorelbine results in decreased expression of PROC protein CTD PMID:10475134 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO vinorelbine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to vinorelbine CTD PMID:16061639 NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964
JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 affects response to substance ISO SLC29A1 protein affects the susceptibility to vinorelbine CTD PMID:18452103 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Vinorelbine results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of TNF mRNA CTD PMID:21544650 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions EXP [Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA CTD PMID:21544650 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO Yohimbine analog results in increased expression of ABCB1 mRNA CTD PMID:7476894 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 increases expression ISO Yohimbine results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO Yohimbine results in decreased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 increases expression ISO Yohimbine results in increased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206
JBrowse link
G Adra2a adrenergic receptor, alpha 2a multiple interactions ISO
EXP
Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Yohimbine binds to and results in decreased activity of ADRA2A protein
CTD PMID:8397342 PMID:10742289 PMID:17666864 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
JBrowse link
G Adrb1 adrenergic receptor, beta 1 multiple interactions ISO [Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein CTD PMID:2868116 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545
JBrowse link
G Aldoc aldolase C, fructose-bisphosphate multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA CTD PMID:28843594 NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr10:122,284,404...122,289,358
Ensembl chr10:122,284,404...122,289,357
JBrowse link
G Bhmt betaine-homocysteine methyltransferase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Calu calumenin increases expression ISO Yohimbine results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
JBrowse link
G Cat catalase multiple interactions ISO Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein] CTD PMID:27028940 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccng1 cyclin G1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdc14b CDC14 cell division cycle 14B multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr13:64,337,085...64,423,670
Ensembl chr13:64,337,082...64,423,104
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr19:21,755,704...21,835,724
Ensembl chr19:21,755,706...21,835,724
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Yohimbine results in decreased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr17:35,269,219...35,277,695
Ensembl chr17:35,268,942...35,277,725
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein] CTD PMID:27028940 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Yohimbine inhibits the reaction [Nitroprusside results in increased expression of and results in increased secretion of CRH protein] CTD PMID:3497798 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA CTD PMID:28843594 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing
affects response to substance
ISO CYP2D6 gene polymorphism affects the metabolism of Yohimbine
CYP2D6 protein affects the susceptibility to Yohimbine
CTD PMID:15289791 PMID:34027562 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA CTD PMID:28843594 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gsr glutathione reductase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A multiple interactions EXP [Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] CTD PMID:8392199 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA CTD PMID:28843594 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Lss lanosterol synthase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Yohimbine results in decreased activity of MAOA protein CTD PMID:28302559 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mir101a microRNA 101a multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 4:101,204,142...101,204,224
Ensembl chr 4:101,204,142...101,204,224
JBrowse link
G Mir122 microRNA 122 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997
JBrowse link
G Mir192 microRNA 192 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr19:6,314,874...6,314,962
Ensembl chr19:6,314,874...6,314,962
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236
JBrowse link
G Myct1 myc target 1 increases expression ISO Yohimbine results in increased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr10:5,543,728...5,556,789
Ensembl chr10:5,543,775...5,556,904
JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta increases expression ISO Yohimbine results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Yohimbine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; Yohimbine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17637181 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA] CTD PMID:1878751 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression ISO Yohimbine results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 7:109,357,263...109,380,752
Ensembl chr 7:109,357,262...109,381,232
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 3:129,672,255...129,689,474
Ensembl chr 3:129,672,255...129,689,474
JBrowse link
G Prl prolactin increases expression ISO Yohimbine results in increased expression of PRL protein CTD PMID:3153710 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein]; Yohimbine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Yohimbine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17637181 PMID:27028940 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein] CTD PMID:27028940 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ren1 renin 1 structural multiple interactions
increases expression
ISO Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]; Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein]; Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]; Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA CTD PMID:28843594 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein] CTD PMID:27028940 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA CTD PMID:28843594 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
zolmitriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD protein] CTD PMID:31129132 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] CTD PMID:31129132 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] CTD PMID:31129132 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:31129132 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] CTD PMID:31129132 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein] CTD PMID:31129132 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO zolmitriptan results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein] CTD PMID:31129132 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 mRNA] CTD PMID:31129132 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of NOS3 mRNA] CTD PMID:31129132 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      biological role 22172
        biochemical role 21436
          metabolite 21384
            alkaloid 7889
              indole alkaloid 1952
                (-)-chuangxinmycin 0
                (15-Ethylidene-6-methoxy-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraen-13-yl)methanol 0
                (19E)-geissoschizine + 0
                (19Z)-geissoschizine 0
                (1R,9R,12R,13S,14R,16S,18R)-13-Ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol 0
                (1R,9R,13S,14R,16S,17S,18R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol 0
                1,2-dehydrogeissoschizoline 0
                1,2-dihydrovomilenine 0
                1-Methoxygelsemine 0
                1-methoxycanthinone 0
                10-deoxysarpagine 0
                10-hydroxycanthin-6-one 0
                10-propionyl-11-methoxy-3-methyl-carboline 0
                11,12-methylenedioxykopsinaline 0
                11-Methoxy-vinorine 0
                12,13-dihydroxyfumitremorgin C 0
                16-epivellosimine 0
                17-O-acetylnorajmaline 0
                18-oxayohimban + 1
                18-oxotryprostatin A 0
                19-(R)-Acetyldihydrogelsevirine 0
                2-(17-Methoxy-11-oxa-7,20-diazahexacyclo[11.7.0.02,7.04,9.08,12.014,19]icosa-1(13),14(19),15,17-tetraen-5-ylidene)ethanol 0
                3-(methylaminomethyl)indole 0
                3alpha(S)-strictosidine 0
                4,21-dehydrogeissoschizine 0
                5-Ethylidene-17-methoxy-11-oxa-7,20-diazahexacyclo[11.7.0.02,7.04,9.08,12.014,19]icosa-1(13),14(19),15,17-tetraene 0
                6-(3-dimethylallyl)harmol 0
                6-bromoconicamin 0
                6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide 0
                6-hydroxydeoxybrevianamide E 0
                6-hydroxytryprostatin B 0
                6-methoxyspirotryprostatin B 0
                7-Ethylidene-1'-methoxy-5-methylspiro[11-oxa-5-azatricyclo[6.3.1.04,9]dodecane-2,3'-indole]-2'-one 0
                9-hydroxycanthin-6-one 5
                9-methoxycanthin-6-one 0
                Adifoline 0
                Affinisine 0
                Akuammidine 0
                Aspidofractine 0
                Aspidosperma alkaloid + 0
                Gardneral 0
                Gelsemicine 0
                Gelsemin 0
                Gelsemine 3
                Isoajmaline 0
                LSM-1353 0
                LSM-21619 0
                LSM-21654 0
                LSM-6400 0
                Methyl (12S,14S,15E)-15-ethylidene-13-(hydroxymethyl)-3-methyl-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraene-13-carboxylate 0
                Methyl (1R,4S,12S,13S,16R,18S)-18-hydroxy-17-oxo-5,14-diazaheptacyclo[12.5.3.01,13.04,12.04,18.06,11.012,16]docosa-6,8,10-triene-5-carboxylate 0
                Methyl (9R,18R,21S)-2-methyl-2,12-diazahexacyclo[14.2.2.19,12.01,9.03,8.016,21]henicosa-3,5,7-triene-18-carboxylate 0
                Methyl 21-hydroxy-5,7-dioxa-2,15-diazaheptacyclo[17.2.2.112,15.01,12.03,11.04,8.019,24]tetracosa-3(11),4(8),9-triene-21-carboxylate 0
                Pericyclivine-N-oxide 0
                Tetraphyllicine 0
                ajmalan + 2
                akuammilan 0
                alcuronium + 3
                alpha-erythroidine 0
                alstonine 0
                alstophyllan 0
                alstoumerine 0
                amataine 0
                aminopyrrolnitrin 0
                aspidofractinine 0
                aspidospermine 0
                beta-carboline alkaloid + 0
                beta-erythroidine + 17
                bromocriptine + 40
                bromodeoxytopsentin 0
                bromotopsentin 0
                bruceolline E 0
                bruceolline F 0
                bruceolline H 0
                bruceolline I 0
                bruceolline J 0
                bruceolline L 0
                bruceolline M 0
                bruceolline N 0
                calycanthaceous alkaloid + 0
                canthin-6-one + 5
                chaetominine 0
                citrinalin B 0
                cladoniamide + 0
                corynan + 0
                corynoxan 0
                cryptolepine 24
                curan 0
                demethoxyfumitremorgin C 8
                deoxybrevianamide E 0
                detajmium 0
                dihydroserpentine(1+) 0
                drymaritin 0
                eburnamenine + 1
                echinulin 0
                ellipticine 31
                ergoline + 18
                ergotaman + 42
                eudistomin C 0
                exiguamine + 0
                fellutanine 0
                formosanan 0
                fumiquinazoline + 0
                fumitremorgin A 0
                fumitremorgin B 0
                fumitremorgin C + 0
                geissoschizoline 0
                geissospermine 0
                glandicoline B + 0
                gramine 4
                hamacanthin A + 0
                hapalindole-type alkaloid + 0
                harman + 73
                harmol + 3
                hippeastrine 0
                hypaphorine 0
                indole-3-carbaldehyde 0
                indolocarbazole alkaloid + 161
                isatinone A 0
                isatinone B 0
                jerantinine A + 0
                jerantinine B 0
                jerantinine C + 0
                jerantinine D 0
                jerantinine E 0
                jerantinine F 0
                kopsan 0
                kopsinine 0
                lorajmine 0
                lumutinine A 0
                lumutinine B 0
                lumutinine C 0
                lumutinine D 0
                lycorenan 0
                maremycin G 0
                martefragin A 0
                meleagrine 0
                methyl (1R,10S,12R,13E,18R)-13-ethylidene-8,15-diazapentacyclo[10.5.1.01,9.02,7.010,15]octadeca-2,4,6,8-tetraene-18-carboxylate 0
                monodechloroaminopyrrolnitrin 0
                norajmaline + 0
                notoamide + 0
                notoamide C 0
                okaramine C 0
                oxaline 0
                perakine 0
                perivine + 0
                physostigmine + 27
                picrinine + 0
                prajmalium 0
                raucaffrinoline 0
                rescinnamine 2
                sarpagan + 0
                sarpagine + 0
                serpentine 1
                strictosidine aglycone 0
                tazettine 0
                terpenoid indole alkaloid + 1507
                thienodolin 0
                tilivalline 0
                tryprostatin A 0
                tryprostatin B 0
                tryptamine + 505
                tryptamine alkaloid + 96
                tubulosan + 0
                vellosimine 0
                verruculogen + 0
                vincane 0
                vobasan + 0
                vobasine 0
                vomilenine + 0
                yohimban + 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      p-block molecular entity 22114
                        carbon group molecular entity 21915
                          organic molecular entity 21840
                            organic group 20283
                              cyclic organic group 1952
                                organic heterobicyclic ring 1952
                                  indole skeleton 1952
                                    indole alkaloid 1952
                                      (-)-chuangxinmycin 0
                                      (15-Ethylidene-6-methoxy-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraen-13-yl)methanol 0
                                      (19E)-geissoschizine + 0
                                      (19Z)-geissoschizine 0
                                      (1R,9R,12R,13S,14R,16S,18R)-13-Ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol 0
                                      (1R,9R,13S,14R,16S,17S,18R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol 0
                                      1,2-dehydrogeissoschizoline 0
                                      1,2-dihydrovomilenine 0
                                      1-Methoxygelsemine 0
                                      1-methoxycanthinone 0
                                      10-deoxysarpagine 0
                                      10-hydroxycanthin-6-one 0
                                      10-propionyl-11-methoxy-3-methyl-carboline 0
                                      11,12-methylenedioxykopsinaline 0
                                      11-Methoxy-vinorine 0
                                      12,13-dihydroxyfumitremorgin C 0
                                      16-epivellosimine 0
                                      17-O-acetylnorajmaline 0
                                      18-oxayohimban + 1
                                      18-oxotryprostatin A 0
                                      19-(R)-Acetyldihydrogelsevirine 0
                                      2-(17-Methoxy-11-oxa-7,20-diazahexacyclo[11.7.0.02,7.04,9.08,12.014,19]icosa-1(13),14(19),15,17-tetraen-5-ylidene)ethanol 0
                                      3-(methylaminomethyl)indole 0
                                      3alpha(S)-strictosidine 0
                                      4,21-dehydrogeissoschizine 0
                                      5-Ethylidene-17-methoxy-11-oxa-7,20-diazahexacyclo[11.7.0.02,7.04,9.08,12.014,19]icosa-1(13),14(19),15,17-tetraene 0
                                      6-(3-dimethylallyl)harmol 0
                                      6-bromoconicamin 0
                                      6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide 0
                                      6-hydroxydeoxybrevianamide E 0
                                      6-hydroxytryprostatin B 0
                                      6-methoxyspirotryprostatin B 0
                                      7-Ethylidene-1'-methoxy-5-methylspiro[11-oxa-5-azatricyclo[6.3.1.04,9]dodecane-2,3'-indole]-2'-one 0
                                      9-hydroxycanthin-6-one 5
                                      9-methoxycanthin-6-one 0
                                      Adifoline 0
                                      Affinisine 0
                                      Akuammidine 0
                                      Aspidofractine 0
                                      Aspidosperma alkaloid + 0
                                      Gardneral 0
                                      Gelsemicine 0
                                      Gelsemin 0
                                      Gelsemine 3
                                      Isoajmaline 0
                                      LSM-1353 0
                                      LSM-21619 0
                                      LSM-21654 0
                                      LSM-6400 0
                                      Methyl (12S,14S,15E)-15-ethylidene-13-(hydroxymethyl)-3-methyl-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraene-13-carboxylate 0
                                      Methyl (1R,4S,12S,13S,16R,18S)-18-hydroxy-17-oxo-5,14-diazaheptacyclo[12.5.3.01,13.04,12.04,18.06,11.012,16]docosa-6,8,10-triene-5-carboxylate 0
                                      Methyl (9R,18R,21S)-2-methyl-2,12-diazahexacyclo[14.2.2.19,12.01,9.03,8.016,21]henicosa-3,5,7-triene-18-carboxylate 0
                                      Methyl 21-hydroxy-5,7-dioxa-2,15-diazaheptacyclo[17.2.2.112,15.01,12.03,11.04,8.019,24]tetracosa-3(11),4(8),9-triene-21-carboxylate 0
                                      Pericyclivine-N-oxide 0
                                      Tetraphyllicine 0
                                      ajmalan + 2
                                      akuammilan 0
                                      alcuronium + 3
                                      alpha-erythroidine 0
                                      alstonine 0
                                      alstophyllan 0
                                      alstoumerine 0
                                      amataine 0
                                      aminopyrrolnitrin 0
                                      aspidofractinine 0
                                      aspidospermine 0
                                      beta-carboline alkaloid + 0
                                      beta-erythroidine + 17
                                      bromocriptine + 40
                                      bromodeoxytopsentin 0
                                      bromotopsentin 0
                                      bruceolline E 0
                                      bruceolline F 0
                                      bruceolline H 0
                                      bruceolline I 0
                                      bruceolline J 0
                                      bruceolline L 0
                                      bruceolline M 0
                                      bruceolline N 0
                                      calycanthaceous alkaloid + 0
                                      canthin-6-one + 5
                                      chaetominine 0
                                      citrinalin B 0
                                      cladoniamide + 0
                                      corynan + 0
                                      corynoxan 0
                                      cryptolepine 24
                                      curan 0
                                      demethoxyfumitremorgin C 8
                                      deoxybrevianamide E 0
                                      detajmium 0
                                      dihydroserpentine(1+) 0
                                      drymaritin 0
                                      eburnamenine + 1
                                      echinulin 0
                                      ellipticine 31
                                      ergoline + 18
                                      ergotaman + 42
                                      eudistomin C 0
                                      exiguamine + 0
                                      fellutanine 0
                                      formosanan 0
                                      fumiquinazoline + 0
                                      fumitremorgin A 0
                                      fumitremorgin B 0
                                      fumitremorgin C + 0
                                      geissoschizoline 0
                                      geissospermine 0
                                      glandicoline B + 0
                                      gramine 4
                                      hamacanthin A + 0
                                      hapalindole-type alkaloid + 0
                                      harman + 73
                                      harmol + 3
                                      hippeastrine 0
                                      hypaphorine 0
                                      indole-3-carbaldehyde 0
                                      indolocarbazole alkaloid + 161
                                      isatinone A 0
                                      isatinone B 0
                                      jerantinine A + 0
                                      jerantinine B 0
                                      jerantinine C + 0
                                      jerantinine D 0
                                      jerantinine E 0
                                      jerantinine F 0
                                      kopsan 0
                                      kopsinine 0
                                      lorajmine 0
                                      lumutinine A 0
                                      lumutinine B 0
                                      lumutinine C 0
                                      lumutinine D 0
                                      lycorenan 0
                                      maremycin G 0
                                      martefragin A 0
                                      meleagrine 0
                                      methyl (1R,10S,12R,13E,18R)-13-ethylidene-8,15-diazapentacyclo[10.5.1.01,9.02,7.010,15]octadeca-2,4,6,8-tetraene-18-carboxylate 0
                                      monodechloroaminopyrrolnitrin 0
                                      norajmaline + 0
                                      notoamide + 0
                                      notoamide C 0
                                      okaramine C 0
                                      oxaline 0
                                      perakine 0
                                      perivine + 0
                                      physostigmine + 27
                                      picrinine + 0
                                      prajmalium 0
                                      raucaffrinoline 0
                                      rescinnamine 2
                                      sarpagan + 0
                                      sarpagine + 0
                                      serpentine 1
                                      strictosidine aglycone 0
                                      tazettine 0
                                      terpenoid indole alkaloid + 1507
                                      thienodolin 0
                                      tilivalline 0
                                      tryprostatin A 0
                                      tryprostatin B 0
                                      tryptamine + 505
                                      tryptamine alkaloid + 96
                                      tubulosan + 0
                                      vellosimine 0
                                      verruculogen + 0
                                      vincane 0
                                      vobasan + 0
                                      vobasine 0
                                      vomilenine + 0
                                      yohimban + 51
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