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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,4'-thiodiphenol
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Accession:CHEBI:38957 term browser browse the term
Definition:A phenol that has formula C12H10O2S.
Synonyms:exact_synonym: 4,4'-sulfanediyldiphenol
 related_synonym: 4,4'-Dihydroxydiphenyl sulfide;   Bis(4-oxyphenyl)sulfide;   Formula=C12H10O2S;   InChI=1S/C12H10O2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8,13-14H;   InChIKey=VWGKEVWFBOUAND-UHFFFAOYSA-N;   SMILES=Oc1ccc(Sc2ccc(O)cc2)cc1;   p,p'-Dihydroxydiphenyl sulfide
 xref: Beilstein:2050739;   CAS:2664-63-3
 xref_mesh: MESH:C586730


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4,4'-thiodiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases expression
multiple interactions
ISO 4,4'-thiodiphenol results in increased expression of ESR1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-thiodiphenol results in increased expression of ESR1 protein]; fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased expression of ESR1 protein]
CTD PMID:27880919 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression
ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-thiodiphenol results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased expression of GPER1 protein] CTD PMID:27880919 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]; wortmannin inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]
CTD PMID:27880919 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]
CTD PMID:27880919 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
temephos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Temefos results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Temefos inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        polyatomic entity 19721
          heteroatomic molecular entity 19647
            hydroxides 19103
              organic hydroxy compound 18658
                phenols 18144
                  4,4'-thiodiphenol 6
                    temephos 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            heteroorganic entity 19175
                              organochalcogen compound 18886
                                organosulfur compound 15218
                                  organic sulfide 8139
                                    aryl sulfide 7478
                                      diphenyl sulfide 6
                                        4,4'-thiodiphenol 6
                                          temephos 2
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