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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridopyrimidine
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Accession:CHEBI:38932 term browser browse the term
Definition:Any organic heterobicyclic compound consisting of a pyridine ring ortho-fused at any position to a pyrimidine ring.
Synonyms:related_synonym: pyridopyrimidines

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Ku-0063794 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Ku 0063794 results in decreased phosphorylation of AKT1 protein CTD PMID:22885370 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with AZD 6244] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with PD 0325901] results in decreased phosphorylation of EIF4EBP1 protein; Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of RPS6 protein
Ku 0063794 results in decreased phosphorylation of RPS6 protein		 CTD PMID:22415236 PMID:22885370 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
palbociclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO palbociclib results in increased expression of ABCA1 mRNA CTD PMID:22869556 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:24986516 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Anln anillin, actin binding protein decreases expression ISO palbociclib results in decreased expression of ANLN mRNA CTD PMID:22869556 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773 		JBrowse link
G Apoe apolipoprotein E increases expression ISO palbociclib results in increased expression of APOE mRNA CTD PMID:28620137 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO palbociclib results in decreased expression of ASF1B mRNA CTD PMID:22869556 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491 		JBrowse link
G Aurka aurora kinase A decreases expression ISO palbociclib results in decreased expression of AURKA mRNA CTD PMID:22869556 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO palbociclib results in decreased expression of AURKB mRNA CTD PMID:22869556 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO palbociclib results in decreased expression of BARD1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO palbociclib results in decreased expression of BIRC5 mRNA CTD PMID:22869556 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO palbociclib results in decreased expression of BORA mRNA CTD PMID:22869556 NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of BUB1 mRNA CTD PMID:22869556 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases cleavage		 ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
palbociclib results in increased cleavage of CASP3 protein
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein
palbociclib results in decreased cleavage of CASP3 protein		 CTD PMID:22302033 PMID:22751436 PMID:23676220 PMID:24098593 PMID:27099147 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein		 CTD PMID:22302033 PMID:24098593 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO palbociclib results in increased expression of CCN1 mRNA CTD PMID:22869556 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO palbociclib results in decreased expression of CCNA2 mRNA; palbociclib results in decreased expression of CCNA2 protein
E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]		 CTD PMID:20100483 PMID:20473330 PMID:21367843 PMID:21593195 PMID:22751436 PMID:22869556 PMID:23708653 PMID:24606660 PMID:26318986 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO palbociclib results in decreased expression of CCNB1 mRNA CTD PMID:22869556 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO palbociclib results in decreased expression of CCNB2 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases response to substance
multiple interactions
increases expression		 ISO CCND1 gene results in decreased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND1 protein
[BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; Doxorubicin inhibits the reaction [palbociclib results in increased expression of CCND1 protein]; palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]		 CTD PMID:20473330 PMID:21278246 PMID:22094256 PMID:22751436 PMID:22869556 PMID:23708653 PMID:24098593 PMID:24986516 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib CTD PMID:24098593 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression		 ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]
[CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND3 protein		 CTD PMID:20473330 PMID:22094256 PMID:24098593 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccne1 cyclin E1 decreases response to substance
decreases expression
increases expression		 ISO CCNE1 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased expression of CCNE1 protein
palbociclib results in increased expression of CCNE1 protein		 CTD PMID:17537993 PMID:21278246 PMID:21880723 PMID:23708653 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO palbociclib analog results in decreased expression of CCNE2 mRNA; palbociclib results in decreased expression of CCNE2 mRNA CTD PMID:15542782 PMID:22869556 PMID:26318986 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Ccnf cyclin F decreases expression ISO palbociclib results in decreased expression of CCNF mRNA CTD PMID:22869556 PMID:24606660 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935 		JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO palbociclib results in decreased expression of CDC20 mRNA CTD PMID:22869556 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO palbociclib results in decreased expression of CDC25A mRNA CTD PMID:22869556 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO palbociclib results in decreased expression of CDC25C mRNA CTD PMID:22869556 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein] CTD PMID:29091774 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO palbociclib results in decreased expression of CDC45 mRNA CTD PMID:22869556 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO palbociclib results in decreased expression of CDCA3 mRNA CTD PMID:22869556 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604 		JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO palbociclib results in decreased expression of CDCA5 mRNA CTD PMID:22869556 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233 		JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO palbociclib results in decreased expression of CDCA8 mRNA CTD PMID:22869556 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526 		JBrowse link
G Cdh1 cadherin 1 affects localization
multiple interactions		 ISO palbociclib affects the localization of CDH1 protein
CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]		 CTD PMID:22094256 PMID:22869556 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression		 ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein] CTD PMID:22869556 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO palbociclib analog results in decreased expression of CDK1 mRNA; palbociclib results in decreased expression of CDK1 mRNA CTD PMID:15542782 PMID:22869556 PMID:24606660 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases phosphorylation
decreases expression		 ISO palbociclib results in decreased activity of CDK2 protein
palbociclib results in increased phosphorylation of and results in increased expression of CDK2 protein
palbociclib results in decreased phosphorylation of CDK2 protein
palbociclib results in decreased expression of CDK2 protein		 CTD PMID:17537993 PMID:20100483 PMID:20473330 PMID:21880723 PMID:22869556 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases response to substance
decreases activity
multiple interactions
increases expression
increases response to substance		 ISO CDK4 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased activity of CDK4 protein
[CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CDK4 protein
palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CDK4 protein results in increased susceptibility to palbociclib		 CTD PMID:20473330 PMID:22094256 PMID:22711607 PMID:22761470 PMID:22869556 PMID:23708653 PMID:24098593 PMID:24795392 PMID:29091774 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression		 ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein]
palbociclib results in increased expression of CDK6 protein
[CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib		 CTD PMID:20473330 PMID:22094256 PMID:22869556 PMID:23138228 PMID:24098593 PMID:29091774 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO palbociclib results in increased expression of CDK7 mRNA CTD PMID:24606660 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO palbociclib results in increased expression of CDKN1A protein CTD PMID:20473330 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
decreases expression		 ISO palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]
palbociclib results in increased expression of CDKN1B mRNA; palbociclib results in increased expression of CDKN1B protein
palbociclib results in decreased expression of CDKN1B protein		 CTD PMID:17537993 PMID:20473330 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects response to substance
increases response to substance
multiple interactions
decreases response to substance		 ISO CDKN2A gene modified form affects the susceptibility to palbociclib; CDKN2A gene mutant form affects the susceptibility to palbociclib; CDKN2A protein affects the susceptibility to palbociclib
CDKN2A gene mutant form results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
CDKN2A protein results in decreased susceptibility to palbociclib
[CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib		 CTD PMID:20534551 PMID:21278246 PMID:22711607 PMID:24098593 PMID:24495407 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression
multiple interactions
decreases response to substance		 ISO palbociclib results in increased expression of CDKN2B protein
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]
CDKN2B protein results in decreased susceptibility to palbociclib		 CTD PMID:22711607 PMID:22869556 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib CTD PMID:20534551 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO palbociclib results in decreased expression of CDKN3 mRNA CTD PMID:22869556 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO palbociclib results in decreased expression of CDT1 mRNA CTD PMID:22869556 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511 		JBrowse link
G Cenpa centromere protein A decreases expression ISO palbociclib results in decreased expression of CENPA mRNA CTD PMID:22869556 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856 		JBrowse link
G Cenpe centromere protein E decreases expression ISO palbociclib results in decreased expression of CENPE mRNA CTD PMID:22869556 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747 		JBrowse link
G Cenpf centromere protein F decreases expression ISO palbociclib results in decreased expression of CENPF mRNA CTD PMID:22869556 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609 		JBrowse link
G Cenpm centromere protein M decreases expression ISO palbociclib results in decreased expression of CENPM mRNA CTD PMID:22869556 NCBI chr 7:123,464,615...123,476,336
Ensembl chr 7:123,464,490...123,476,238 		JBrowse link
G Cep55 centrosomal protein 55 decreases expression ISO palbociclib results in decreased expression of CEP55 mRNA CTD PMID:22869556 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796 		JBrowse link
G Ckap2l cytoskeleton associated protein 2-like decreases expression ISO palbociclib results in decreased expression of CKAP2L mRNA CTD PMID:22869556 NCBI chr 3:121,796,221...121,822,352
Ensembl chr 3:121,796,238...121,822,436 		JBrowse link
G Cpa4 carboxypeptidase A4 increases expression ISO palbociclib results in increased expression of CPA4 mRNA CTD PMID:22869556 NCBI chr 4:57,883,849...57,907,826
Ensembl chr 4:57,883,849...57,907,826 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CTNNB1 protein] CTD PMID:22869556 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Dennd6b DENN domain containing 6B increases expression ISO palbociclib results in increased expression of DENND6B mRNA CTD PMID:22869556 NCBI chr 7:130,162,728...130,178,282
Ensembl chr 7:130,164,675...130,176,696 		JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO palbociclib results in decreased expression of DEPDC1B mRNA CTD PMID:22869556 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975 		JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO palbociclib results in decreased expression of DLGAP5 mRNA CTD PMID:22869556 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON decreases expression ISO palbociclib results in decreased expression of DONSON mRNA CTD PMID:22869556 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]] CTD PMID:22751436 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions
decreases expression		 ISO E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased expression of RNR2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
palbociclib results in decreased expression of E2F2 mRNA		 CTD PMID:20100483 PMID:20473330 PMID:22869556 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G Eln elastin increases expression ISO palbociclib results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863 		JBrowse link
G Exo1 exonuclease 1 decreases expression ISO palbociclib results in decreased expression of EXO1 mRNA CTD PMID:22869556 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO palbociclib results in decreased expression of EZH2 mRNA; palbociclib results in decreased expression of EZH2 protein CTD PMID:20948315 PMID:22869556 PMID:24736461 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO palbociclib results in increased expression of F3 mRNA CTD PMID:22869556 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fam111a FAM111 trypsin like peptidase A decreases expression ISO palbociclib results in decreased expression of FAM111A mRNA CTD PMID:22869556 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527 		JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO palbociclib results in decreased expression of FAM83D mRNA CTD PMID:22869556 NCBI chr 3:155,269,344...155,288,612
Ensembl chr 3:155,269,347...155,288,533 		JBrowse link
G Fance FA complementation group E decreases expression ISO palbociclib results in decreased expression of FANCE mRNA CTD PMID:28620137 NCBI chr20:7,888,927...7,906,142
Ensembl chr20:7,895,083...7,906,142 		JBrowse link
G Fanci FA complementation group I decreases expression ISO palbociclib results in decreased expression of FANCI mRNA CTD PMID:22869556 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483 		JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO palbociclib results in decreased expression of FBXO5 mRNA CTD PMID:22869556 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO palbociclib results in decreased expression of FEN1 mRNA CTD PMID:22869556 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression
affects response to substance
decreases phosphorylation
multiple interactions		 ISO palbociclib results in decreased expression of FLT3 mRNA; palbociclib results in decreased expression of FLT3 protein
FLT3 protein affects the susceptibility to palbociclib
palbociclib results in decreased phosphorylation of FLT3 protein
[FLT3 protein affects the susceptibility to palbociclib] which results in decreased expression of FLT3 protein		 CTD PMID:27099147 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]; CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]; palbociclib results in decreased expression of and results in decreased activity of FOXM1 protein
palbociclib results in decreased expression of FOXM1 mRNA		 CTD PMID:22094256 PMID:22869556 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305 		JBrowse link
G Gins2 GINS complex subunit 2 decreases expression ISO palbociclib results in decreased expression of GINS2 mRNA CTD PMID:22869556 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608 		JBrowse link
G Gls glutaminase increases expression ISO palbociclib results in increased expression of GLS mRNA CTD PMID:28620137 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872 		JBrowse link
G Gmnn geminin, DNA replication inhibitor decreases expression ISO palbociclib results in decreased expression of GMNN mRNA CTD PMID:22869556 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783 		JBrowse link
G Gpsm2 G-protein signaling modulator 2 decreases expression ISO palbociclib results in decreased expression of GPSM2 mRNA CTD PMID:22869556 NCBI chr 2:211,480,120...211,528,096
Ensembl chr 2:211,480,400...211,527,919 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO palbociclib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases phosphorylation		 ISO Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein] CTD PMID:22302033 PMID:22751436 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hjurp Holliday junction recognition protein decreases expression ISO palbociclib results in decreased expression of HJURP mRNA CTD PMID:22869556 NCBI chr 9:95,347,739...95,362,228
Ensembl chr 9:95,349,086...95,362,014 		JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO palbociclib results in decreased expression of HMGB2 mRNA CTD PMID:22869556 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO palbociclib results in decreased expression of HMMR mRNA CTD PMID:22869556 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein CTD PMID:24986516 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression ISO palbociclib results in increased expression of IL20RB mRNA CTD PMID:22869556 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717 		JBrowse link
G Incenp inner centromere protein decreases expression ISO palbociclib results in decreased expression of INCENP mRNA CTD PMID:22869556 NCBI chr 1:225,923,448...225,953,384
Ensembl chr 1:225,925,773...225,952,516 		JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO palbociclib results in decreased expression of KIF11 mRNA CTD PMID:22869556 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299 		JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO palbociclib results in decreased expression of KIF14 mRNA CTD PMID:22869556 NCBI chr13:53,350,073...53,421,992
Ensembl chr13:53,351,717...53,420,111 		JBrowse link
G Kif15 kinesin family member 15 decreases expression ISO palbociclib results in decreased expression of KIF15 mRNA CTD PMID:22869556 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO palbociclib results in decreased expression of KIF20A mRNA CTD PMID:22869556 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814 		JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO palbociclib results in decreased expression of KIF23 mRNA CTD PMID:22869556 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196 		JBrowse link
G Kif2c kinesin family member 2C decreases expression ISO palbociclib results in decreased expression of KIF2C mRNA CTD PMID:22869556 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210 		JBrowse link
G Kif4a kinesin family member 4A decreases expression ISO palbociclib results in decreased expression of KIF4A mRNA CTD PMID:22869556 NCBI chr  X:70,461,700...70,561,084
Ensembl chr  X:70,461,718...70,561,189 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO palbociclib results in decreased expression of KIFC1 mRNA CTD PMID:22869556 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175 		JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression ISO palbociclib results in decreased expression of KNSTRN mRNA CTD PMID:22869556 NCBI chr 3:110,618,256...110,638,024
Ensembl chr 3:110,618,298...110,638,046 		JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO palbociclib results in decreased expression of KPNA2 mRNA CTD PMID:22869556 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO palbociclib results in increased expression of LAMA3 mRNA CTD PMID:22869556 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO palbociclib results in increased expression of LAMB3 mRNA CTD PMID:22869556 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO palbociclib results in increased expression of LAMC2 mRNA CTD PMID:22869556 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252 		JBrowse link
G Lmnb1 lamin B1 decreases expression ISO palbociclib results in decreased expression of LMNB1 mRNA CTD PMID:22869556 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264 		JBrowse link
G LOC100912489 histone H4-like decreases expression ISO palbociclib results in decreased expression of H4C3 mRNA CTD PMID:22869556 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO palbociclib results in decreased expression of MCM10 mRNA CTD PMID:22869556 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 multiple interactions
decreases expression		 ISO RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]
palbociclib results in decreased expression of MCM7 mRNA; palbociclib results in decreased expression of MCM7 protein		 CTD PMID:20473330 PMID:22869556 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016 		JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein] CTD PMID:22094256 NCBI chr 2:187,511,775...187,541,285
Ensembl chr 2:187,512,164...187,538,026 		JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO palbociclib results in decreased expression of MELK mRNA CTD PMID:22869556 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression		 ISO Doxorubicin promotes the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein] CTD PMID:15542782 PMID:22170262 PMID:22383795 PMID:22751436 PMID:23708653 PMID:26318986 PMID:28620137 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mxd4 Max dimerization protein 4 increases expression ISO palbociclib results in increased expression of MXD4 mRNA CTD PMID:22869556 NCBI chr14:81,819,415...81,833,456
Ensembl chr14:81,819,415...81,833,456 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO palbociclib results in decreased expression of MYC protein CTD PMID:27099147 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 decreases expression ISO palbociclib results in decreased expression of NCAPD2 mRNA CTD PMID:22869556 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596 		JBrowse link
G Ncapg non-SMC condensin I complex, subunit G decreases expression ISO palbociclib results in decreased expression of NCAPG mRNA CTD PMID:22869556 NCBI chr14:69,898,268...69,927,885
Ensembl chr14:69,899,128...69,927,938 		JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO palbociclib results in decreased expression of NCAPG2 mRNA CTD PMID:22869556 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947 		JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO palbociclib results in decreased expression of NDC80 mRNA CTD PMID:22869556 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382 		JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO palbociclib results in decreased expression of NEK2 mRNA CTD PMID:22869556 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO palbociclib results in decreased expression of NUSAP1 mRNA CTD PMID:22869556 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971 		JBrowse link
G Oip5 Opa interacting protein 5 decreases expression ISO palbociclib results in decreased expression of OIP5 mRNA CTD PMID:22869556 NCBI chr 3:111,413,662...111,422,320
Ensembl chr 3:111,416,536...111,422,203 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]] CTD PMID:22751436 PMID:23676220 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pbk PDZ binding kinase decreases expression ISO palbociclib results in decreased expression of PBK mRNA CTD PMID:22869556 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395 		JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO palbociclib results in decreased expression of PCLAF mRNA CTD PMID:22869556 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO palbociclib results in decreased expression of PCNA mRNA; palbociclib results in decreased expression of PCNA protein CTD PMID:20473330 PMID:22869556 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]] CTD PMID:21880723 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO palbociclib results in decreased expression of PHF19 mRNA CTD PMID:22869556 NCBI chr 3:13,957,136...13,978,283
Ensembl chr 3:13,957,136...13,978,224 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of PIM1 mRNA CTD PMID:27099147 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555 		JBrowse link
G Pimreg PICALM interacting mitotic regulator decreases expression ISO palbociclib results in decreased expression of PIMREG mRNA CTD PMID:22869556 NCBI chr10:58,613,588...58,618,524
Ensembl chr10:58,613,674...58,618,514 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression
multiple interactions		 ISO palbociclib results in decreased expression of PLK1 mRNA
palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]		 CTD PMID:20100483 PMID:22869556 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989 		JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLA2 mRNA CTD PMID:22869556 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLE2 mRNA CTD PMID:22869556 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996 		JBrowse link
G Porcn porcupine O-acyltransferase increases expression ISO palbociclib results in increased expression of PORCN mRNA CTD PMID:22869556 NCBI chr  X:15,035,569...15,048,440
Ensembl chr  X:15,035,569...15,048,440 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO palbociclib results in decreased expression of PRC1 mRNA CTD PMID:22869556 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746 		JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO palbociclib results in decreased expression of PRIM1 mRNA CTD PMID:22869556 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165 		JBrowse link
G Prr11 proline rich 11 decreases expression ISO palbociclib results in decreased expression of PRR11 mRNA CTD PMID:22869556 NCBI chr10:74,393,683...74,436,073
Ensembl chr10:74,393,699...74,413,745 		JBrowse link
G Prss23 serine protease 23 increases expression ISO palbociclib results in increased expression of PRSS23 mRNA CTD PMID:22869556 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541 		JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO palbociclib results in decreased expression of PSRC1 mRNA CTD PMID:22869556 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO palbociclib results in decreased expression of PTTG1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO palbociclib results in decreased expression of RACGAP1 mRNA CTD PMID:22869556 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO palbociclib results in decreased expression of RAD51AP1 mRNA CTD PMID:22869556 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO palbociclib results in decreased expression of RANBP1 mRNA CTD PMID:28620137 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
decreases expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance
affects reaction
increases phosphorylation
decreases phosphorylation		 ISO palbociclib affects the phosphorylation of RB1 protein
palbociclib results in decreased expression of RB1 mRNA; palbociclib results in decreased expression of RB1 protein
RB1 protein results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to palbociclib
BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RB1 protein]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RB1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 gene mutant form results in decreased susceptibility to palbociclib; RB1 mutant form results in decreased susceptibility to palbociclib
RB1 protein affects the reaction palbociclib
palbociclib results in increased phosphorylation of RB1 protein		 CTD PMID:15542782 PMID:16690963 PMID:17537993 PMID:19435910 PMID:19874578 PMID:20100483 PMID:20354191 PMID:20473330 PMID:20534551 PMID:21217777 PMID:21278246 PMID:21367843 PMID:21593195 PMID:21880723 PMID:22094256 PMID:22170262 PMID:22383795 PMID:22751436 PMID:22761470 PMID:22869556 PMID:23138228 PMID:23676220 PMID:23708653 PMID:24098593 PMID:24495407 PMID:24736461 PMID:24986516 PMID:25221644 PMID:26174628 PMID:26318986 PMID:26873845 PMID:28620137 PMID:30684532 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of RBL1 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]; palbociclib promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein]; palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RBL1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]
palbociclib results in decreased expression of RBL1 mRNA; palbociclib results in decreased expression of RBL1 protein		 CTD PMID:20100483 PMID:20473330 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases phosphorylation		 ISO palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib results in decreased phosphorylation of and results in increased expression of RBL2 protein; palbociclib results in increased expression of and results in increased stability of RBL2 protein
palbociclib results in decreased phosphorylation of RBL2 protein		 CTD PMID:20100483 PMID:20473330 PMID:22094256 PMID:26174628 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808 		JBrowse link
G Rdh5 retinol dehydrogenase 5 increases expression ISO palbociclib results in increased expression of RDH5 mRNA CTD PMID:22869556 NCBI chr 7:3,335,681...3,342,573
Ensembl chr 7:3,335,742...3,342,491 		JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO palbociclib results in decreased expression of RFC5 mRNA CTD PMID:22869556 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324 		JBrowse link
G Rps29 ribosomal protein S29 increases expression ISO palbociclib results in increased expression of RPS29 mRNA CTD PMID:22869556 NCBI chr 6:91,455,333...91,456,709
Ensembl chr 6:91,455,333...91,456,696
Ensembl chr 3:91,455,333...91,456,696
Ensembl chr 7:91,455,333...91,456,696 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:24986516 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO palbociclib results in decreased expression of RRM1 mRNA CTD PMID:22869556 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO palbociclib results in decreased expression of RRM2 mRNA CTD PMID:22869556 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G Sapcd2 suppressor APC domain containing 2 decreases expression ISO palbociclib results in decreased expression of SAPCD2 mRNA CTD PMID:22869556 NCBI chr 3:2,590,355...2,597,283
Ensembl chr 3:2,591,331...2,596,583 		JBrowse link
G Senp3 SUMO specific peptidase 3 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein] CTD PMID:22094256 NCBI chr10:56,277,609...56,286,867
Ensembl chr10:56,277,615...56,286,391 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO palbociclib results in increased expression of SERPINE1 mRNA CTD PMID:22869556 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Shox2 short stature homeobox 2 multiple interactions ISO palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein] CTD PMID:22094256 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783 		JBrowse link
G Slc16a4 solute carrier family 16, member 4 increases expression ISO palbociclib results in increased expression of SLC16A4 mRNA CTD PMID:22869556 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO palbociclib results in decreased expression of SMC4 mRNA CTD PMID:22869556 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
increases expression		 ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein] CTD PMID:22869556 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO palbociclib results in increased expression of SPARC mRNA CTD PMID:28620137 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185 		JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC24 mRNA CTD PMID:22869556 NCBI chr 8:22,780,639...22,785,908
Ensembl chr 8:22,780,725...22,785,671 		JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC25 mRNA CTD PMID:22869556 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798 		JBrowse link
G Stil STIL, centriolar assembly protein decreases expression ISO palbociclib results in decreased expression of STIL mRNA CTD PMID:22869556 NCBI chr 5:133,819,302...133,851,362
Ensembl chr 5:133,819,726...133,851,416 		JBrowse link
G Stmn1 stathmin 1 decreases expression ISO palbociclib results in decreased expression of STMN1 mRNA CTD PMID:22869556 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO palbociclib results in decreased expression of TACC3 mRNA CTD PMID:28620137 NCBI chr14:82,336,283...82,350,069
Ensembl chr14:82,336,324...82,347,679 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases activity ISO palbociclib results in increased activity of TGFB1 protein CTD PMID:22869556 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO palbociclib analog results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 protein CTD PMID:15542782 PMID:22170262 PMID:22869556 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884 		JBrowse link
G Tmpo thymopoietin decreases expression ISO palbociclib results in decreased expression of TMPO mRNA CTD PMID:22869556 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423 		JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO palbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290 		JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO palbociclib results in decreased expression of TOP1 mRNA CTD PMID:24549232 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions		 ISO palbociclib analog results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A protein
palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]		 CTD PMID:15542782 PMID:20948315 PMID:22751436 PMID:22869556 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Tp53 tumor protein p53 decreases response to substance ISO TP53 protein mutant form results in decreased susceptibility to palbociclib CTD PMID:21278246 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO palbociclib results in decreased expression of TPX2 mRNA CTD PMID:22869556 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187 		JBrowse link
G Troap trophinin associated protein decreases expression ISO palbociclib results in decreased expression of TROAP mRNA CTD PMID:22869556 NCBI chr 7:140,758,576...140,766,423
Ensembl chr 7:140,758,615...140,766,423 		JBrowse link
G Ttc14 tetratricopeptide repeat domain 14 increases expression ISO palbociclib results in increased expression of TTC14 mRNA CTD PMID:22869556 NCBI chr 2:120,266,883...120,277,505
Ensembl chr 2:120,266,933...120,276,616 		JBrowse link
G Ttk Ttk protein kinase decreases expression ISO palbociclib results in decreased expression of TTK mRNA CTD PMID:22869556 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression ISO palbociclib results in decreased expression of TUBB4B mRNA CTD PMID:22869556 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO palbociclib results in decreased expression of TUBB mRNA CTD PMID:22869556 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371 		JBrowse link
G Tyms thymidylate synthetase decreases expression ISO palbociclib results in decreased expression of TYMS mRNA; palbociclib results in decreased expression of TYMS protein CTD PMID:20948315 PMID:22869556 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO palbociclib results in decreased expression of UBE2C mRNA CTD PMID:22869556 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159 		JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T decreases expression ISO palbociclib results in decreased expression of UBE2T mRNA CTD PMID:22869556 NCBI chr13:51,790,877...51,801,379
Ensembl chr13:51,795,867...51,801,163 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO palbociclib results in decreased expression of UHRF1 mRNA CTD PMID:22869556 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Vim vimentin increases expression ISO palbociclib results in increased expression of VIM protein CTD PMID:22869556 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein] CTD PMID:22094256 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914 		JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO palbociclib results in decreased expression of ZWINT mRNA CTD PMID:22869556 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766 		JBrowse link
paliperidone palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
multiple interactions
increases export
increases transport
affects response to substance
decreases activity		 ISO
EXP		 ABCB1 gene polymorphism affects the abundance of Paliperidone Palmitate; ABCB1 protein affects the abundance of Paliperidone Palmitate
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]
ABCB1A protein results in increased transport of Paliperidone Palmitate
ABCB1A protein affects the susceptibility to Paliperidone Palmitate
Paliperidone Palmitate results in decreased activity of ABCB1 protein
Paliperidone Palmitate inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased transport of Paliperidone Palmitate		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17541883 PMID:22691713 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Paliperidone Palmitate CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Paliperidone Palmitate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Paliperidone Palmitate results in increased expression of BDNF mRNA CTD PMID:21220416 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects abundance ISO CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate; CYP2D6 protein affects the abundance of Paliperidone Palmitate CTD PMID:10639689 PMID:15089809 PMID:17541883 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding		 ISO
EXP		 Paliperidone Palmitate binds to and results in decreased activity of DRD2 protein
Paliperidone Palmitate binds to DRD2 protein		 CTD PMID:19713555 PMID:22437487 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 EXP Paliperidone Palmitate results in increased expression of FADS2 mRNA
[Paliperidone Palmitate results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding
multiple interactions		 ISO
EXP		 Paliperidone Palmitate binds to HTR2A protein
Paliperidone Palmitate binds to and results in decreased activity of HTR2A protein		 CTD PMID:7520908 PMID:19713555 PMID:22437487 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Paliperidone Palmitate results in decreased activity of KCNH2 protein CTD PMID:21394035 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Prl prolactin increases expression ISO Paliperidone Palmitate results in increased expression of PRL protein CTD PMID:17460786 PMID:19825908 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
PD-166866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 PMID:15773903 PMID:16524372 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
multiple interactions		 ISO
EXP		 PD 166866 results in decreased activity of FGFR1 protein
PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]; PD 166866 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]		 CTD PMID:12805413 PMID:15522930 PMID:15773903 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein] CTD PMID:15773903 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA] CTD PMID:16524372 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Postn periostin multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087 		JBrowse link
PD173074 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [arsenic trioxide results in increased susceptibility to PD 173074] which results in decreased expression of BIRC5 protein CTD PMID:27794399 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [PKI 166 co-treated with PD 173074] results in decreased expression of CCND1 protein CTD PMID:15377668 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein] CTD PMID:15709206 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf16 fibroblast growth factor 16 multiple interactions ISO PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK1 protein]; PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:24253043 NCBI chr  X:76,786,728...76,796,311
Ensembl chr  X:76,786,466...76,797,069 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases expression
multiple interactions		 ISO PD 173074 results in decreased activity of FGFR1 protein
PD 173074 results in decreased expression of FGFR1 protein
[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]; Arsenic Trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of FGFR1 protein]		 CTD PMID:22683780 PMID:27794399 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO PD 173074 results in decreased activity of FGFR3 protein CTD PMID:15029211 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 multiple interactions
decreases activity		 ISO PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]
PD 173074 results in decreased activity of FGFR4 protein		 CTD PMID:15377668 PMID:15709206 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases expression
multiple interactions		 ISO PD 173074 results in decreased phosphorylation of MAPK1 protein
PD 173074 results in decreased expression of MAPK1 protein
PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein]
PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15029211 PMID:24253043 PMID:25953896 PMID:27794399 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
decreases expression
multiple interactions		 ISO PD 173074 results in decreased phosphorylation of MAPK3 protein
PD 173074 results in decreased expression of MAPK3 protein
PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK3 protein]
PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15029211 PMID:24253043 PMID:25953896 PMID:27794399 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [arsenic trioxide co-treated with PD 173074] results in increased expression of PARP1 protein modified form; [arsenic trioxide results in increased susceptibility to PD 173074] which results in increased expression of PARP1 protein modified form; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in increased expression of PARP1 protein modified form CTD PMID:27794399 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 multiple interactions ISO PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein]; PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:25953896 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions		 ISO PD 173074 results in decreased expression of RAF1 protein; PD 173074 results in decreased expression of RAF1 protein modified form
[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein; [arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form; [arsenic trioxide results in increased susceptibility to PD 173074] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in decreased expression of RAF1 protein modified form; arsenic trioxide promotes the reaction [PD 173074 results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein]		 CTD PMID:27794399 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [PKI 166 co-treated with PD 173074] results in decreased activity of RPS6KB1 protein CTD PMID:15377668 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases expression		 ISO [Arsenic Trioxide co-treated with PD 173074] results in decreased expression of SRC protein; [Arsenic Trioxide results in increased susceptibility to PD 173074] which results in decreased expression of SRC protein; [PD 173074 results in increased susceptibility to Arsenic Trioxide] which results in decreased expression of SRC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Arsenic Trioxide co-treated with PD 173074] results in decreased expression of SRC protein]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of SRC protein modified form]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of SRC protein]
PD 173074 results in decreased expression of SRC protein; PD 173074 results in decreased expression of SRC protein modified form		 CTD PMID:27794399 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]; PD 173074 inhibits the reaction [Estrogens results in increased expression of TBX3 protein] CTD PMID:21098263 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA]]; PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA] CTD PMID:26800359 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
pemirolast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP pemirolast inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
decreases secretion		 EXP pemirolast inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein]; pemirolast inhibits the reaction [Paclitaxel results in increased secretion of TAC1 protein alternative form]
pemirolast results in decreased secretion of TAC1 protein		 CTD PMID:15033348 PMID:21233199 PMID:21539837 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
pipemidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Pipemidic Acid CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
multiple interactions
increases export
increases transport
decreases activity
affects response to substance
increases response to substance		 ISO
EXP		 ABCB1 gene polymorphism affects the abundance of Risperidone; ABCB1 protein affects the abundance of Risperidone
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]
ABCB1A protein results in increased transport of Risperidone
Risperidone results in decreased activity of ABCB1 protein
ABCB1A protein affects the susceptibility to Risperidone
ABCB1 protein results in increased transport of Risperidone
Risperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased susceptibility to Risperidone
ABCB1 gene polymorphism affects the susceptibility to Risperidone; ABCB1 protein affects the susceptibility to Risperidone		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17054409 PMID:17541883 PMID:18708991 PMID:19997080 PMID:20563569 PMID:21449914 PMID:22623266 PMID:22691713 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Risperidone CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions		 EXP
ISO		 Risperidone results in decreased expression of BDNF mRNA
BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]		 CTD PMID:12393228 PMID:17442543 PMID:19997080 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Calm2 calmodulin 2 increases expression EXP Risperidone results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Risperidone results in decreased expression of CAMK2A protein CTD PMID:19289156 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP Risperidone results in decreased expression of CAMK4 protein CTD PMID:19289156 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Risperidone results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Risperidone results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Risperidone results in increased expression of CEBPA mRNA; Risperidone results in increased expression of CEBPA protein		 CTD PMID:20564506 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects response to substance ISO CHRM4 affects the susceptibility to Risperidone CTD PMID:21269601 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Risperidone results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein] CTD PMID:16144542 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
increases response to substance
affects response to substance
decreases hydroxylation
decreases metabolic processing
affects abundance
multiple interactions		 ISO CYP2D6 gene polymorphism affects the metabolism of Risperidone; CYP2D6 protein affects the metabolism of Risperidone
CYP2D6 protein results in increased metabolism of Risperidone
CYP2D6 protein results in increased susceptibility to Risperidone
CYP2D6 gene polymorphism affects the susceptibility to Risperidone; CYP2D6 protein polymorphism affects the susceptibility to Risperidone
CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone
CYP2D6 gene polymorphism results in decreased metabolism of Risperidone
CYP2D6 gene polymorphism affects the abundance of Risperidone; CYP2D6 protein affects the abundance of Risperidone
CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone; CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone		 CTD PMID:10639689 PMID:15089809 PMID:15260906 PMID:15565299 PMID:15669884 PMID:16044105 PMID:17224713 PMID:17541883 PMID:18708991 PMID:19387994 PMID:20332423 PMID:20563569 PMID:21449914 PMID:22623266 PMID:22745940 PMID:23609392 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
affects response to substance		 ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
CYP3A4 gene polymorphism affects the susceptibility to Risperidone; CYP3A4 protein affects the susceptibility to Risperidone		 CTD PMID:19395426 PMID:21402137 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects abundance
increases metabolic processing		 ISO CYP3A5 gene polymorphism affects the abundance of Risperidone; CYP3A5 protein affects the abundance of Risperidone
CYP3A5 protein results in increased metabolism of Risperidone		 CTD PMID:18708991 PMID:20332423 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases response to substance
affects response to substance		 ISO
EXP		 Risperidone binds to and results in decreased activity of DRD2 protein
Risperidone binds to DRD2 protein
[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]
DRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to Risperidone
DRD2 gene polymorphism affects the susceptibility to Risperidone		 CTD PMID:1380082 PMID:7520908 PMID:8804920 PMID:10831489 PMID:12191584 PMID:15710053 PMID:15716360 PMID:16033416 PMID:16144542 PMID:16513859 PMID:18058087 PMID:19339912 PMID:19640686 PMID:19910723 PMID:20361897 PMID:20375926 PMID:21869689 PMID:22437487 PMID:22967779 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 gene SNP results in increased susceptibility to Risperidone; DRD3 protein results in increased susceptibility to Risperidone CTD PMID:19506579 PMID:19997080 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein] CTD PMID:16144542 NCBI chr11:84,051,177...84,068,479
Ensembl chr11:84,051,078...84,068,302 		JBrowse link
G Egr1 early growth response 1 decreases expression EXP Risperidone results in decreased expression of EGR1 protein CTD PMID:17028028 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Egr2 early growth response 2 decreases expression EXP Risperidone results in decreased expression of EGR2 protein CTD PMID:17028028 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases phosphorylation EXP Risperidone results in increased phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Risperidone results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 EXP Risperidone results in increased expression of FADS2 mRNA
[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA] CTD PMID:20564506 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Risperidone promotes the reaction [Rotenone results in increased expression of FOS mRNA]
Risperidone results in increased expression of FOS mRNA		 CTD PMID:11516571 PMID:17442543 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Risperidone affects the expression of FSHB protein CTD PMID:18838228 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions		 EXP Risperidone results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]		 CTD PMID:16144542 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein] CTD PMID:16144542 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Risperidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Risperidone results in increased expression of HOMER1 mRNA CTD PMID:20147574 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases response to substance
multiple interactions		 EXP HTR1A protein results in increased susceptibility to Risperidone
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]		 CTD PMID:17530476 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
affects response to substance		 ISO
EXP		 HTR2A gene SNP results in increased susceptibility to Risperidone; HTR2A protein results in increased susceptibility to Risperidone
Risperidone binds to HTR2A protein
Risperidone binds to and results in decreased activity of HTR2A protein; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; Risperidone binds to and results in decreased activity of HTR2A protein
HTR2A protein affects the susceptibility to Risperidone		 CTD PMID:7520908 PMID:11927170 PMID:12191584 PMID:16314884 PMID:16948927 PMID:19997080 PMID:22437487 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects response to substance
multiple interactions
increases response to substance		 ISO HTR2C gene polymorphism affects the susceptibility to Risperidone; HTR2C protein affects the susceptibility to Risperidone
HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
HTR2C protein results in increased susceptibility to Risperidone		 CTD PMID:19142101 PMID:19997080 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions ISO HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein] CTD PMID:19997080 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO 2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Risperidone binds to and results in decreased activity of HTR7 protein; SB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778 		JBrowse link
G Inha inhibin subunit alpha multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400 		JBrowse link
G Inhbb inhibin subunit beta B multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222 		JBrowse link
G Ins2 insulin 2 increases expression ISO Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA] CTD PMID:20564506 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Maoa monoamine oxidase A affects response to substance
increases response to substance		 ISO MAOA gene polymorphism affects the susceptibility to Risperidone
MAOA protein results in increased susceptibility to Risperidone		 CTD PMID:22544010 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B increases expression EXP Risperidone results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Risperidone results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Risperidone results in decreased expression of NGFR mRNA CTD PMID:12111809 PMID:16513140 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:21402137 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nrg1 neuregulin 1 increases expression EXP Risperidone results in increased expression of NRG1 protein CTD PMID:26961615 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO Risperidone results in increased expression of PPARG mRNA; Risperidone results in increased expression of PPARG protein
Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]		 CTD PMID:20564506 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
decreases expression		 EXP [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Risperidone results in decreased expression of PPP3CA mRNA; Risperidone results in decreased expression of PPP3CA protein		 CTD PMID:16033416 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression		 ISO
EXP		 [Risperidone co-treated with Clozapine] results in increased expression of PRL protein; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]; BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]		 CTD PMID:1380082 PMID:9696519 PMID:9989566 PMID:10084644 PMID:11048906 PMID:11155212 PMID:11561931 PMID:11927762 PMID:12902212 PMID:12974991 PMID:15206663 PMID:15286066 PMID:15289996 PMID:15669890 PMID:15960571 PMID:16379509 PMID:16730335 PMID:17224713 PMID:18063941 PMID:18080171 PMID:18466271 PMID:18562423 PMID:18759643 PMID:18838228 PMID:19653986 PMID:19825908 PMID:19906340 PMID:19997080 PMID:20373475 PMID:20661022 PMID:20814333 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP Risperidone results in increased expression of RGS2 mRNA CTD PMID:11516571 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094 		JBrowse link
G S100b S100 calcium binding protein B increases secretion EXP Risperidone results in increased secretion of S100B protein CTD PMID:18421423 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Risperidone results in increased expression of SLC17A6 mRNA; Risperidone results in increased expression of SLC17A6 protein CTD PMID:18155072 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to Risperidone CTD PMID:15823421 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP Risperidone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Risperidone results in increased expression of SOD1 mRNA		 CTD PMID:12111809 PMID:12752374 PMID:16564057 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Risperidone results in increased expression of SREBF1 mRNA; Risperidone results in increased expression of SREBF1 protein		 CTD PMID:20564506 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Risperidone inhibits the reaction [Rotenone results in decreased expression of STAT3 mRNA] CTD PMID:17442543 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP Risperidone results in increased expression of TH protein CTD PMID:17028028 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
trametinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA] CTD PMID:29950559 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA] CTD PMID:29950559 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO trametinib results in increased phosphorylation of AKT1 protein
[omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein		 CTD PMID:22733540 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO [trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein
trametinib results in increased expression of BCL2L11 protein		 CTD PMID:22733540 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein] CTD PMID:27556948 PMID:29950559 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein CTD PMID:22733540 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein CTD PMID:22733540 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA] CTD PMID:25780039 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:25780039 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA] CTD PMID:29950559 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance ISO GNA11 protein mutant form results in increased susceptibility to trametinib CTD PMID:22733540 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases response to substance		 ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]
GNAQ protein mutant form results in increased susceptibility to trametinib		 CTD PMID:22733540 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:25780039 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib] CTD PMID:22733540 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO trametinib affects the expression of and affects the lipidation of MAP1LC3B protein CTD PMID:30339727 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases response to substance
multiple interactions		 ISO MAP2K1 protein mutant form results in decreased susceptibility to trametinib
[MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:29768711 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]		 CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 PMID:29950559 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]		 CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 PMID:29950559 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO trametinib results in decreased expression of MYC protein CTD PMID:22733540 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ngfr nerve growth factor receptor increases expression
affects response to substance		 ISO trametinib results in increased expression of NGFR protein
NGFR protein affects the susceptibility to trametinib		 CTD PMID:30339727 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RB1 protein CTD PMID:22733540 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:22733540 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO trametinib results in decreased expression of SQSTM1 protein CTD PMID:30339727 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein] CTD PMID:29950559 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      molecular entity 19839
        polyatomic entity 19754
          molecule 19587
            cyclic compound 19404
              bicyclic compound 16900
                heterobicyclic compound 16808
                  organic heterobicyclic compound 16808
                    pyridopyrimidine 274
                      1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulfanyl]-7-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-one 0
                      1-(2-methoxyethyl)-7-thiophen-2-yl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-2,4-dione 0
                      1-(3,4-dimethylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile 0
                      1-(3-ethoxypropyl)-2-[2-furanyl(oxo)methyl]imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                      1-[(7-chloro-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl]-3-(3-fluoro-4-methylphenyl)thieno[3,2-d]pyrimidine-2,4-dione 0
                      1-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-10-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                      1-[3-[2-cyano-3-(2-furanylmethylamino)-3-oxoprop-1-enyl]-4-oxo-2-pyrido[1,2-a]pyrimidinyl]-4-piperidinecarboxamide 0
                      1-butyl-2,4-dioxo-7-thiophen-2-yl-5-pyrido[2,3-d]pyrimidinecarboxylic acid ethyl ester 0
                      1-butyl-2-[2-furanyl(oxo)methyl]imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                      1-cyclopentyl-2-imino-10-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                      1-tert-butyl-3-[2-\{[4-(diethylamino)butyl]amino\}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea 0
                      2-(3-ethoxypropylamino)-8-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[1,2-pyrimidinecarboxamide 0
                      2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-pyridinecarboxylic acid propan-2-yl ester 0
                      2-[2-furanyl(oxo)methyl]imino-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester 0
                      2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid 0
                      2-[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]-oxomethyl]imino-1-(2-methylpropyl)-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester 0
                      2-benzoylimino-1-(2-furanylmethyl)-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                      2-bromo-6-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                      2-chloro-6-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                      2-chloro-8-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                      2-cyano-3-[2-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide 0
                      2-imino-1-[(4-methylphenyl)methyl]-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                      2-imino-10-methyl-N-[2-(4-morpholinyl)ethyl]-5-oxo-1-(3-pyridinylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                      2-imino-8-methyl-5-oxo-1-(2-oxolanylmethyl)-N-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                      2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                      2-methyl-1-cyclopropanecarboxylic acid (7-bromo-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl ester 0
                      3-(3,4-dimethylphenyl)sulfonyl-2-imino-1-prop-2-enyl-5-dipyrido[1,2-e:4',3'-f]pyrimidinone 0
                      3-(4-chlorophenyl)sulfonyl-2-imino-1-(2-phenylethyl)-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                      3-(4-fluorophenyl)sulfonyl-1-(2-furanylmethyl)-2-imino-10-methyl-5-dipyrido[3,4-c:1',2'-f]pyrimidinone 0
                      3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                      3-(benzenesulfonyl)-2-imino-1-propyl-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                      3-[(3-chlorophenyl)methyl]-5-ethoxy-1,6-dimethylpyrido[2,3-d]pyrimidine-2,4-dione 0
                      3-[(4-chloroanilino)methylidene]-2-(2-hydroxyethylimino)-9-methyl-4-pyrido[1,2-a]pyrimidinone 0
                      3-[2,4-dioxo-1-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl]-3-quinazolinyl]-N-(2-furanylmethyl)propanamide 0
                      3-[2-(1-azepanyl)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-(2-furanylmethyl)-2-propenamide 0
                      3-[2-[bis(phenylmethyl)amino]-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-methyl-2-propenamide 0
                      3-[4-oxo-2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-thieno[3,2-d]pyrimidinyl]propanoic acid 0
                      3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate + 12
                      3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one + 0
                      3-ethyl-2-sulfanylidene-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-4-one 0
                      5-[[2-(diethylamino)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]methylidene]-1,3-diazinane-2,4,6-trione 0
                      5-deazafolic acid 0
                      5-methyl-6-[(quinolin-5-ylamino)methyl]pyrido[2,3-d]pyrimidine-2,4-diamine 0
                      5-methyl-6-\{[methyl(3,4,5-trimethoxyphenyl)amino]methyl\}pyrido[2,3-d]pyrimidine-2,4-diamine 0
                      6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine 0
                      6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 0
                      6-(2,6-dichlorophenyl)-2-\{[3-(hydroxymethyl)phenyl]amino\}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 0
                      6-[(Z)-2-(2,5-dimethoxyphenyl)ethenyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine 0
                      6-[4-oxo-2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-thieno[3,2-d]pyrimidinyl]hexanoic acid 0
                      6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one 0
                      6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one 0
                      6-propan-2-yl-2-sulfanylidene-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one 0
                      7-methyl-4-oxo-2-[(phenylmethyl)amino]-3-pyrido[1,2-a]pyrimidinecarboxaldehyde 0
                      8-(1-piperidinylsulfonyl)-6-pyrido[1,2-a]quinazolinone 0
                      8-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinecarboxylic acid ethyl ester 0
                      9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one 0
                      9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one 0
                      9-(1-anilinoethyl)-7-methyl-2-(4-morpholinyl)-4-pyrido[1,2-a]pyrimidinone 0
                      9-methyl-4-oxo-2-(1-piperidinyl)-3-pyrido[1,2-a]pyrimidinecarboxaldehyde oxime 0
                      AZD-8055 0
                      Carolinianine 0
                      Deazaflavin 0
                      Ku-0063794 3
                      LSM-16446 0
                      LSM-16483 0
                      LSM-20487 0
                      LSM-25801 0
                      LSM-26967 0
                      LSM-27960 0
                      LSM-28172 0
                      LSM-28559 0
                      LSM-31933 0
                      LSM-33283 0
                      N(6)-(2,5-dimethoxybenzyl)-N(6)-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                      N(6)-(3,5-dimethoxybenzyl)-N(6)-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                      N(6)-methyl-N(6)-(3,4,5-trimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                      N-(2-furanylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]-2-imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                      N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                      N-[(4-\{2-[(6R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}phenyl)carbonyl]-L-glutamic acid 0
                      N-[(4-\{2-[(6S)-2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}phenyl)carbonyl]-L-glutamic acid 0
                      N-[(5-\{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}thiophen-2-yl)carbonyl]-L-glutamic acid 0
                      N-[3-cyano-1-(2-furanylmethyl)-10-methyl-5-oxo-2-dipyrido[3,4-c:1',2'-f]pyrimidinylidene]-2-furancarboxamide 0
                      N-\{[4-([(2-amino-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]\{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]prop-2-enoyl\}amino)phenyl]carbonyl\}-L-glutamic acid 0
                      N-cyclopentyl-2-imino-1-[3-(4-morpholinyl)propyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                      N-ethyl-2-imino-10-methyl-1-[(4-methylphenyl)methyl]-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                      N6,N6-dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine 0
                      PD-166866 + 21
                      PD158780 0
                      PD173074 18
                      PD173955 + 0
                      dicloromezotiaz 0
                      linkable PD173955 analogue 0
                      palbociclib 176
                      pamapimod 0
                      pemirolast 2
                      pipemidic acid 1
                      piromidic acid 0
                      rimazolium 0
                      risperidone 62
                      trametinib + 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteropolycyclic compound 17874
                                    organic heterobicyclic compound 16808
                                      pyridopyrimidine 274
                                        1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulfanyl]-7-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-one 0
                                        1-(2-methoxyethyl)-7-thiophen-2-yl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-2,4-dione 0
                                        1-(3,4-dimethylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile 0
                                        1-(3-ethoxypropyl)-2-[2-furanyl(oxo)methyl]imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                                        1-[(7-chloro-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl]-3-(3-fluoro-4-methylphenyl)thieno[3,2-d]pyrimidine-2,4-dione 0
                                        1-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-10-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                                        1-[3-[2-cyano-3-(2-furanylmethylamino)-3-oxoprop-1-enyl]-4-oxo-2-pyrido[1,2-a]pyrimidinyl]-4-piperidinecarboxamide 0
                                        1-butyl-2,4-dioxo-7-thiophen-2-yl-5-pyrido[2,3-d]pyrimidinecarboxylic acid ethyl ester 0
                                        1-butyl-2-[2-furanyl(oxo)methyl]imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                                        1-cyclopentyl-2-imino-10-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                                        1-tert-butyl-3-[2-\{[4-(diethylamino)butyl]amino\}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea 0
                                        2-(3-ethoxypropylamino)-8-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[1,2-pyrimidinecarboxamide 0
                                        2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-pyridinecarboxylic acid propan-2-yl ester 0
                                        2-[2-furanyl(oxo)methyl]imino-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester 0
                                        2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid 0
                                        2-[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]-oxomethyl]imino-1-(2-methylpropyl)-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester 0
                                        2-benzoylimino-1-(2-furanylmethyl)-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester 0
                                        2-bromo-6-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                                        2-chloro-6-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                                        2-chloro-8-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone 0
                                        2-cyano-3-[2-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide 0
                                        2-imino-1-[(4-methylphenyl)methyl]-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                                        2-imino-10-methyl-N-[2-(4-morpholinyl)ethyl]-5-oxo-1-(3-pyridinylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                                        2-imino-8-methyl-5-oxo-1-(2-oxolanylmethyl)-N-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                                        2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                                        2-methyl-1-cyclopropanecarboxylic acid (7-bromo-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl ester 0
                                        3-(3,4-dimethylphenyl)sulfonyl-2-imino-1-prop-2-enyl-5-dipyrido[1,2-e:4',3'-f]pyrimidinone 0
                                        3-(4-chlorophenyl)sulfonyl-2-imino-1-(2-phenylethyl)-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                                        3-(4-fluorophenyl)sulfonyl-1-(2-furanylmethyl)-2-imino-10-methyl-5-dipyrido[3,4-c:1',2'-f]pyrimidinone 0
                                        3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                                        3-(benzenesulfonyl)-2-imino-1-propyl-5-dipyrido[1,2-d:3',4'-f]pyrimidinone 0
                                        3-[(3-chlorophenyl)methyl]-5-ethoxy-1,6-dimethylpyrido[2,3-d]pyrimidine-2,4-dione 0
                                        3-[(4-chloroanilino)methylidene]-2-(2-hydroxyethylimino)-9-methyl-4-pyrido[1,2-a]pyrimidinone 0
                                        3-[2,4-dioxo-1-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl]-3-quinazolinyl]-N-(2-furanylmethyl)propanamide 0
                                        3-[2-(1-azepanyl)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-(2-furanylmethyl)-2-propenamide 0
                                        3-[2-[bis(phenylmethyl)amino]-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-methyl-2-propenamide 0
                                        3-[4-oxo-2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-thieno[3,2-d]pyrimidinyl]propanoic acid 0
                                        3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate + 12
                                        3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one + 0
                                        3-ethyl-2-sulfanylidene-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-4-one 0
                                        5-[[2-(diethylamino)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]methylidene]-1,3-diazinane-2,4,6-trione 0
                                        5-deazafolic acid 0
                                        5-methyl-6-[(quinolin-5-ylamino)methyl]pyrido[2,3-d]pyrimidine-2,4-diamine 0
                                        5-methyl-6-\{[methyl(3,4,5-trimethoxyphenyl)amino]methyl\}pyrido[2,3-d]pyrimidine-2,4-diamine 0
                                        6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine 0
                                        6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 0
                                        6-(2,6-dichlorophenyl)-2-\{[3-(hydroxymethyl)phenyl]amino\}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 0
                                        6-[(Z)-2-(2,5-dimethoxyphenyl)ethenyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine 0
                                        6-[4-oxo-2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-thieno[3,2-d]pyrimidinyl]hexanoic acid 0
                                        6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one 0
                                        6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one 0
                                        6-propan-2-yl-2-sulfanylidene-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one 0
                                        7-methyl-4-oxo-2-[(phenylmethyl)amino]-3-pyrido[1,2-a]pyrimidinecarboxaldehyde 0
                                        8-(1-piperidinylsulfonyl)-6-pyrido[1,2-a]quinazolinone 0
                                        8-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinecarboxylic acid ethyl ester 0
                                        9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one 0
                                        9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one 0
                                        9-(1-anilinoethyl)-7-methyl-2-(4-morpholinyl)-4-pyrido[1,2-a]pyrimidinone 0
                                        9-methyl-4-oxo-2-(1-piperidinyl)-3-pyrido[1,2-a]pyrimidinecarboxaldehyde oxime 0
                                        AZD-8055 0
                                        Carolinianine 0
                                        Deazaflavin 0
                                        Ku-0063794 3
                                        LSM-16446 0
                                        LSM-16483 0
                                        LSM-20487 0
                                        LSM-25801 0
                                        LSM-26967 0
                                        LSM-27960 0
                                        LSM-28172 0
                                        LSM-28559 0
                                        LSM-31933 0
                                        LSM-33283 0
                                        N(6)-(2,5-dimethoxybenzyl)-N(6)-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                                        N(6)-(3,5-dimethoxybenzyl)-N(6)-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                                        N(6)-methyl-N(6)-(3,4,5-trimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine 0
                                        N-(2-furanylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]-2-imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                                        N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                                        N-[(4-\{2-[(6R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}phenyl)carbonyl]-L-glutamic acid 0
                                        N-[(4-\{2-[(6S)-2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}phenyl)carbonyl]-L-glutamic acid 0
                                        N-[(5-\{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}thiophen-2-yl)carbonyl]-L-glutamic acid 0
                                        N-[3-cyano-1-(2-furanylmethyl)-10-methyl-5-oxo-2-dipyrido[3,4-c:1',2'-f]pyrimidinylidene]-2-furancarboxamide 0
                                        N-\{[4-([(2-amino-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]\{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]prop-2-enoyl\}amino)phenyl]carbonyl\}-L-glutamic acid 0
                                        N-cyclopentyl-2-imino-1-[3-(4-morpholinyl)propyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide 0
                                        N-ethyl-2-imino-10-methyl-1-[(4-methylphenyl)methyl]-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide 0
                                        N6,N6-dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine 0
                                        PD-166866 + 21
                                        PD158780 0
                                        PD173074 18
                                        PD173955 + 0
                                        dicloromezotiaz 0
                                        linkable PD173955 analogue 0
                                        palbociclib 176
                                        pamapimod 0
                                        pemirolast 2
                                        pipemidic acid 1
                                        piromidic acid 0
                                        rimazolium 0
                                        risperidone 62
                                        trametinib + 26
paths to the root