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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzooxepine
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Accession:CHEBI:38926 term browser browse the term
Synonyms:related_synonym: dibenzooxepines


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doxepin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Doxepin CTD PMID:14550684 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Doxepin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ache acetylcholinesterase increases activity ISO Doxepin results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Doxepin results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]
CTD PMID:31743544 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Doxepin results in increased expression of ASNS mRNA CTD PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Doxepin results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Doxepin results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Doxepin results in increased expression of GDPD3 mRNA CTD PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Doxepin results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Doxepin results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31743544 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Doxepin results in increased expression of INHBE mRNA CTD PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Doxepin inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Doxepin results in increased expression of SERPINA3 mRNA CTD PMID:17567588 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G Lss lanosterol synthase increases expression ISO Doxepin results in increased expression of LSS mRNA CTD PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Doxepin results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Doxepin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Doxepin results in decreased expression of SLC2A3 mRNA CTD PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Doxepin results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tagln transgelin decreases expression ISO Doxepin results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO
EXP
Doxepin results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:31743544 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      molecular entity 19768
        polyatomic entity 19686
          molecule 19534
            cyclic compound 19367
              polycyclic compound 18620
                heteropolycyclic compound 17978
                  heterotricyclic compound 14600
                    organic heterotricyclic compound 14600
                      dibenzooxepine 22
                        CGP-3466 0
                        arugosin A (lactol form) 0
                        arugosin B 0
                        bauhinoxepin B 0
                        bauhinoxepin F 0
                        bauhinoxepin I 0
                        bauhinoxepin J 0
                        callophycoic acid A 0
                        callophycoic acid B 0
                        callophycoic acid C 0
                        callophycoic acid D 0
                        callophycoic acid E 0
                        desmethyldoxepin + 0
                        doxepin + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      dibenzooxepine 22
                                        CGP-3466 0
                                        arugosin A (lactol form) 0
                                        arugosin B 0
                                        bauhinoxepin B 0
                                        bauhinoxepin F 0
                                        bauhinoxepin I 0
                                        bauhinoxepin J 0
                                        callophycoic acid A 0
                                        callophycoic acid B 0
                                        callophycoic acid C 0
                                        callophycoic acid D 0
                                        callophycoic acid E 0
                                        desmethyldoxepin + 0
                                        doxepin + 22
paths to the root