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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
octoclothepine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Dothiepin results in increased expression of ABCC2 protein |
CTD |
PMID:12524417 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
EXP |
Methiothepin binds to and results in decreased activity of ADRA1A protein |
CTD |
PMID:16545797 |
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NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
ISO EXP |
Methiothepin binds to and results in decreased activity of HTR1A protein |
CTD |
PMID:2207497 PMID:15482641 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1b |
5-hydroxytryptamine receptor 1B |
affects binding |
EXP |
Methiothepin binds to HTR1B protein |
CTD |
PMID:11888550 |
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NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions |
ISO |
[Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine |
CTD |
PMID:10764922 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Htr5b |
5-hydroxytryptamine (serotonin) receptor 5B |
multiple interactions |
EXP |
methiothepin binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b] |
RGD |
PMID:8224165 |
RGD:2303647 |
NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
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G |
Htr7 |
5-hydroxytryptamine receptor 7 |
multiple interactions |
ISO |
[Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Methiothepin binds to and results in decreased activity of HTR7 protein] which results in decreased abundance of Cyclic AMP; Methiothepin binds to and results in decreased activity of HTR7 protein |
CTD |
PMID:14578406 PMID:18996971 PMID:19509219 |
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NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Methiothepin results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Prl |
prolactin |
decreases expression |
ISO |
zotepine results in decreased expression of PRL protein |
CTD |
PMID:18063941 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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