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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzochromene
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Accession:CHEBI:38920 term browser browse the term
Synonyms:related_synonym: benzochromenes


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11-hydroxy-Delta(9)-tetrahydrocannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp1 fatty acid binding protein 1 multiple interactions ISO
EXP
[FABP1 protein affects the transport of Dronabinol] which affects the abundance of 11-hydroxy-delta(9)-tetrahydrocannabinol
11-hydroxy-delta(9)-tetrahydrocannabinol affects the folding of and results in increased stability of FABP1 protein; 11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [anandamide analog binds to FABP1 protein]
11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [11-(dansylamino)undecanoic acid binds to FABP1 protein]
CTD PMID:30232874 PMID:31110286 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions EXP 11-hydroxy-delta(9)-tetrahydrocannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
alternariol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects response to substance
multiple interactions
ISO AHR protein affects the susceptibility to alternariol
AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
CTD PMID:22120949 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alpp alkaline phosphatase, placental increases expression ISO alternariol results in increased expression of ALPP mRNA CTD PMID:32328700 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
JBrowse link
G Ar androgen receptor decreases activity ISO alternariol results in decreased activity of AR protein CTD PMID:27481073 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
affects response to substance
ISO ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
ARNT protein affects the susceptibility to alternariol
CTD PMID:22120949 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Casp3 caspase 3 increases activity ISO alternariol results in increased activity of CASP3 protein CTD PMID:22542754 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO alternariol results in increased activity of CASP9 protein CTD PMID:22542754 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO alternariol results in increased expression of CCND1 protein
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CCND1 protein]; butaprost promotes the reaction [alternariol results in increased expression of CCND1 protein]
CTD PMID:30503586 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd68 Cd68 molecule increases expression ISO alternariol results in increased expression of CD68 protein CTD PMID:26341179 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cd83 CD83 molecule increases expression ISO alternariol results in increased expression of CD83 protein CTD PMID:26341179 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule increases expression ISO alternariol results in increased expression of CD86 protein CTD PMID:26341179 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO alternariol results in increased expression of CREB1 protein modified form
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]
CTD PMID:30503586 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases activity ISO alternariol results in decreased activity of CSNK2A1 protein CTD PMID:32328700 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO alternariol results in increased expression of CYP11B2 mRNA CTD PMID:23665424 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO alternariol results in increased expression of CYP17A1 mRNA CTD PMID:23665424 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO alternariol results in increased expression of CYP19A1 mRNA CTD PMID:23665424 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects expression
affects activity
increases expression
ISO AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
alternariol affects the expression of CYP1A1 mRNA
alternariol affects the activity of CYP1A1 protein
alternariol results in increased expression of CYP1A1 mRNA
CTD PMID:22120949 PMID:23665424 PMID:26474839 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO alternariol results in decreased activity of GSR protein CTD PMID:25827405 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects localization ISO alternariol affects the localization of GSTA1 mRNA CTD PMID:23154127 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects localization ISO alternariol affects the localization of GSTA2 mRNA CTD PMID:23154127 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G H2ax H2A.X variant histone increases expression ISO alternariol results in increased expression of H2AX protein modified form CTD PMID:26341179 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO alternariol results in increased expression of HSD3B2 mRNA CTD PMID:23665424 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
ISO alternariol results in increased expression of IL6 mRNA
alternariol results in increased secretion of IL6 protein
CTD PMID:26341179 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO alternariol results in increased expression of ITGAM protein CTD PMID:26341179 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Mc2r melanocortin 2 receptor increases expression ISO alternariol results in increased expression of MC2R mRNA CTD PMID:23665424 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [altertoxin II co-treated with alternariol] results in decreased expression of MIR192 mRNA CTD PMID:28007639 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mir224 microRNA 224 multiple interactions ISO [altertoxin II co-treated with alternariol] results in increased expression of MIR224 mRNA CTD PMID:28007639 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169
JBrowse link
G Mir29a microRNA 29a increases expression ISO alternariol results in increased expression of MIR29A mRNA CTD PMID:28007639 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO alternariol results in decreased phosphorylation of MTOR protein CTD PMID:25456271 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO alternariol affects the localization of NFE2L2 protein CTD PMID:23154127 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression ISO alternariol results in decreased expression of NR0B1 mRNA CTD PMID:23665424 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO alternariol results in increased expression of PGR protein
fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein]
CTD PMID:23665424 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression
multiple interactions
ISO alternariol results in increased expression of PTGER2 protein
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGER2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGER2 protein]
CTD PMID:30503586 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [alternariol results in increased expression of PTGER4 protein] CTD PMID:30503586 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGS2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGS2 protein] CTD PMID:30503586 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO alternariol results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25456271 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sesn2 sestrin 2 increases expression ISO alternariol results in increased expression of SESN2 protein CTD PMID:25456271 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
ISO alternariol results in increased secretion of TNF protein
alternariol results in increased expression of TNF mRNA
CTD PMID:26341179 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO alternariol metabolite results in decreased activity of TOP2A protein; alternariol results in decreased activity of TOP2A protein CTD PMID:27422292 PMID:27682608 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta decreases activity ISO alternariol metabolite results in decreased activity of TOP2B protein; alternariol results in decreased activity of TOP2B protein CTD PMID:27422292 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 increases expression ISO alternariol results in increased expression of TP53 protein CTD PMID:22542754 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
beta-lapachone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Becn1 beclin 1 affects response to substance ISO BECN1 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein CTD PMID:21035436 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of beta-lapachone CTD PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
Delta(9)-tetrahydrocannabinolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Colforsin results in increased activity of CNR1 protein] CTD PMID:28861508 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:28861508 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP delta(9)-tetrahydrocannabinolic acid results in increased expression of FOSB protein alternative form CTD PMID:18293355 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Il6 interleukin 6 multiple interactions ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of IL6 mRNA] CTD PMID:28853159 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]] CTD PMID:28853159 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
increases expression
ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Rosiglitazone results in increased expression of PPARG mRNA]
delta(9)-tetrahydrocannabinolic acid results in decreased expression of PPARG protein
delta(9)-tetrahydrocannabinolic acid results in increased expression of PPARG mRNA
CTD PMID:28853159 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO delta(9)-tetrahydrocannabinolic acid results in increased expression of PPARGC1A mRNA CTD PMID:28853159 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]] CTD PMID:28853159 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
rubimaillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
CTD PMID:23466342 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of ACACA protein CTD PMID:23466342 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO rubimaillin results in decreased phosphorylation of AKT1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein]
CTD PMID:23466342 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of BID protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein]
CTD PMID:19716835 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP12 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]
CTD PMID:19716835 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP3 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein]
CTD PMID:19716835 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP7 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]
CTD PMID:19716835 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP8 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]
CTD PMID:19716835 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP9 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein]
CTD PMID:19716835 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of CFLAR protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]
CTD PMID:19716835 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
ISO rubimaillin results in decreased expression of CREB1 mRNA
rubimaillin results in decreased phosphorylation of CREB1 protein
CTD PMID:23466342 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO rubimaillin results in increased phosphorylation of GSK3B protein CTD PMID:23466342 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of NFKBIA protein CTD PMID:23466342 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
ISO rubimaillin results in increased degradation of PARP1 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]
CTD PMID:19716835 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein CTD PMID:23466342 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
rubimaillin results in decreased expression of RELA protein
CTD PMID:23466342 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO rubimaillin results in increased phosphorylation of STK11 protein CTD PMID:23466342 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
splitomicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] CTD PMID:18482975 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Casp3 caspase 3 multiple interactions ISO splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein] CTD PMID:24040102 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G F2 coagulation factor II multiple interactions ISO splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Histamine co-treated with splitomicin] results in increased expression of F3 protein; splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 protein] CTD PMID:23525482 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases expression EXP splitomicin results in decreased expression of KCNA5 mRNA CTD PMID:25447406 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Klkb1 kallikrein B1 increases response to substance
multiple interactions
ISO KLKB1 gene mutant form results in increased susceptibility to splitomicin
splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]
CTD PMID:25339356 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG protein] CTD PMID:23525482 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
splitomicin results in decreased activity of SIRT1 protein
splitomicin results in decreased expression of SIRT1 mRNA
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein]
CTD PMID:18482975 PMID:20978007 PMID:25447406 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tf transferrin increases activity ISO splitomicin results in increased activity of TF protein CTD PMID:20978007 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              organooxygen compound 19014
                oxacycle 17587
                  benzochromene 74
                    2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid 0
                    Delta(9)-tetrahydrocannabinol + 2
                    Delta(9)-tetrahydrocannabinolic acid 8
                    JWH-133 0
                    benzochromenone + 56
                    botrallin 0
                    lapachenole 0
                    rhizopycnolide A 0
                    rubimaillin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterotricyclic compound 14645
                                      benzochromene 74
                                        2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid 0
                                        Delta(9)-tetrahydrocannabinol + 2
                                        Delta(9)-tetrahydrocannabinolic acid 8
                                        JWH-133 0
                                        benzochromenone + 56
                                        botrallin 0
                                        lapachenole 0
                                        rhizopycnolide A 0
                                        rubimaillin 18
paths to the root