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G |
Fabp1 |
fatty acid binding protein 1 |
multiple interactions |
ISO EXP |
[FABP1 protein affects the transport of Dronabinol] which affects the abundance of 11-hydroxy-delta(9)-tetrahydrocannabinol 11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [11-(dansylamino)undecanoic acid binds to FABP1 protein] 11-hydroxy-delta(9)-tetrahydrocannabinol affects the folding of and results in increased stability of FABP1 protein; 11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [anandamide analog binds to FABP1 protein] |
CTD |
PMID:30232874 PMID:31110286 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Trpv2 |
transient receptor potential cation channel, subfamily V, member 2 |
multiple interactions |
EXP |
11-hydroxy-delta(9)-tetrahydrocannabinol binds to and results in increased activity of TRPV2 protein |
CTD |
PMID:18550765 |
|
NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
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|
G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
affects metabolic processing |
ISO |
UGT1A9 gene SNP affects the metabolism of 11-hydroxy-delta(9)-tetrahydrocannabinol |
CTD |
PMID:30191314 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ahr |
aryl hydrocarbon receptor |
affects response to substance multiple interactions |
ISO |
AHR protein affects the susceptibility to alternariol AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] [alternariol co-treated with altertoxin II co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] affects the localization of AHR protein; [alternariol co-treated with altertoxin II] promotes the reaction [IL1B protein affects the localization of AHR protein]; alternariol inhibits the reaction [altertoxin II affects the localization of AHR protein]; alternariol promotes the reaction [IL1B protein affects the localization of AHR protein] |
CTD |
PMID:22120949 PMID:35405071 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Alpp |
alkaline phosphatase, placental |
increases expression |
ISO |
alternariol results in increased expression of ALPP mRNA |
CTD |
PMID:32328700 |
|
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Ar |
androgen receptor |
decreases activity |
ISO |
alternariol results in decreased activity of AR protein |
CTD |
PMID:27481073 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions affects response to substance |
ISO |
ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] ARNT protein affects the susceptibility to alternariol |
CTD |
PMID:22120949 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
alternariol results in increased activity of CASP3 protein |
CTD |
PMID:22542754 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
alternariol results in increased activity of CASP9 protein |
CTD |
PMID:22542754 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of CCND1 protein 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CCND1 protein]; butaprost promotes the reaction [alternariol results in increased expression of CCND1 protein] |
CTD |
PMID:30503586 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd68 |
Cd68 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD68 protein |
CTD |
PMID:26341179 |
|
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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G |
Cd83 |
CD83 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD83 protein |
CTD |
PMID:26341179 |
|
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD86 protein |
CTD |
PMID:26341179 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of CREB1 protein modified form 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form] |
CTD |
PMID:30503586 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
decreases activity |
ISO |
alternariol results in decreased activity of CSNK2A1 protein |
CTD |
PMID:32328700 |
|
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression |
ISO |
alternariol results in increased expression of CYP11B2 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
alternariol results in increased expression of CYP17A1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression |
ISO |
alternariol results in increased expression of CYP19A1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions affects expression affects activity increases expression |
ISO |
AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] alternariol affects the expression of CYP1A1 mRNA alternariol affects the activity of CYP1A1 protein alternariol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:22120949 PMID:23665424 PMID:26474839 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
ISO |
alternariol results in decreased activity of GSR protein |
CTD |
PMID:25827405 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
affects localization |
ISO |
alternariol affects the localization of GSTA1 mRNA |
CTD |
PMID:23154127 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects localization |
ISO |
alternariol affects the localization of GSTA2 mRNA |
CTD |
PMID:23154127 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
alternariol results in increased expression of H2AX protein modified form |
CTD |
PMID:26341179 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
increases expression |
ISO |
alternariol results in increased expression of HSD3B2 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [[alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [alternariol affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of MMP9 mRNA]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of TJP1 mRNA]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of TJP1 protein]; [alternariol co-treated with altertoxin II] promotes the reaction [IL1B protein affects the localization of AHR protein]; [altertoxin II co-treated with alternariol] affects the reaction [IL1B protein affects the expression of CXCL8 mRNA]; [altertoxin II co-treated with alternariol] affects the reaction [IL1B protein affects the expression of TNF mRNA]; alternariol affects the reaction [altertoxin II affects the reaction [IL1B protein affects the secretion of CXCL8 protein]]; alternariol affects the reaction [IL1B protein affects the expression of CXCL8 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of MMP2 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of MMP9 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of TNF mRNA]; alternariol affects the reaction [IL1B protein affects the secretion of CXCL8 protein]; alternariol inhibits the reaction [IL1B protein affects the localization of RELA protein]; alternariol promotes the reaction [IL1B protein affects the localization of AHR protein]; altertoxin II affects the reaction [alternariol affects the reaction [IL1B protein affects the expression of MMP2 mRNA]]; altertoxin II affects the reaction [alternariol affects the reaction [IL1B protein affects the secretion of CXCL8 protein]] |
CTD |
PMID:35405071 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
increases expression increases secretion |
ISO |
alternariol results in increased expression of IL6 mRNA alternariol results in increased secretion of IL6 protein |
CTD |
PMID:26341179 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
alternariol results in increased expression of ITGAM protein |
CTD |
PMID:26341179 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions |
ISO |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [[alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [alternariol affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of ITGB1 mRNA] |
CTD |
PMID:35405071 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Mc2r |
melanocortin 2 receptor |
increases expression |
ISO |
alternariol results in increased expression of MC2R mRNA |
CTD |
PMID:23665424 |
|
NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
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G |
Mir192 |
microRNA 192 |
multiple interactions |
ISO |
[altertoxin II co-treated with alternariol] results in decreased expression of MIR192 mRNA |
CTD |
PMID:28007639 |
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NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
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G |
Mir224 |
microRNA 224 |
multiple interactions |
ISO |
[altertoxin II co-treated with alternariol] results in increased expression of MIR224 mRNA |
CTD |
PMID:28007639 |
|
NCBI chr X:150,065,088...150,065,169
Ensembl chr X:150,065,088...150,065,169
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G |
Mir29a |
microRNA 29a |
increases expression |
ISO |
alternariol results in increased expression of MIR29A mRNA |
CTD |
PMID:28007639 |
|
NCBI chr 4:59,650,608...59,650,695
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
alternariol affects the reaction [IL1B protein affects the expression of MMP2 mRNA]; altertoxin II affects the reaction [alternariol affects the reaction [IL1B protein affects the expression of MMP2 mRNA]] |
CTD |
PMID:35405071 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
[alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of MMP9 mRNA]; alternariol affects the reaction [IL1B protein affects the expression of MMP9 mRNA] |
CTD |
PMID:35405071 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
alternariol results in decreased phosphorylation of MTOR protein |
CTD |
PMID:25456271 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions |
ISO |
alternariol affects the localization of NFE2L2 protein 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[alternariol co-treated with altertoxin II] affects the localization of NFE2L2 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [alternariol affects the localization of NFE2L2 protein]; [alternariol co-treated with altertoxin II] affects the localization of NFE2L2 protein |
CTD |
PMID:23154127 PMID:35405071 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr0b1 |
nuclear receptor subfamily 0, group B, member 1 |
decreases expression |
ISO |
alternariol results in decreased expression of NR0B1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr X:50,756,886...50,761,014
Ensembl chr X:50,756,886...50,761,011
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G |
Pgr |
progesterone receptor |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of PGR protein fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein] |
CTD |
PMID:23665424 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Ptger2 |
prostaglandin E receptor 2 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of PTGER2 protein 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGER2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGER2 protein] |
CTD |
PMID:30503586 |
|
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptger4 |
prostaglandin E receptor 4 |
multiple interactions increases expression |
ISO |
L-161982 inhibits the reaction [alternariol results in increased expression of PTGER4 protein] |
CTD |
PMID:30503586 |
|
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGS2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGS2 protein] |
CTD |
PMID:30503586 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
alternariol inhibits the reaction [IL1B protein affects the localization of RELA protein] |
CTD |
PMID:35405071 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
alternariol results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:25456271 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Sesn2 |
sestrin 2 |
increases expression |
ISO |
alternariol results in increased expression of SESN2 protein |
CTD |
PMID:25456271 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
[alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of TJP1 mRNA]; [alternariol co-treated with altertoxin II] affects the reaction [IL1B protein affects the expression of TJP1 protein]; [alternariol co-treated with altertoxin II] results in increased expression of TJP1 protein |
CTD |
PMID:35405071 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tnf |
tumor necrosis factor |
increases secretion multiple interactions increases expression |
ISO |
alternariol results in increased secretion of TNF protein [altertoxin II co-treated with alternariol] affects the reaction [IL1B protein affects the expression of TNF mRNA]; alternariol affects the reaction [IL1B protein affects the expression of TNF mRNA] alternariol results in increased expression of TNF mRNA |
CTD |
PMID:26341179 PMID:35405071 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Top2a |
DNA topoisomerase II alpha |
decreases activity |
ISO |
alternariol metabolite results in decreased activity of TOP2A protein; alternariol results in decreased activity of TOP2A protein |
CTD |
PMID:27422292 PMID:27682608 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Top2b |
DNA topoisomerase II beta |
decreases activity |
ISO |
alternariol metabolite results in decreased activity of TOP2B protein; alternariol results in decreased activity of TOP2B protein |
CTD |
PMID:27422292 |
|
NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
alternariol results in increased expression of TP53 protein |
CTD |
PMID:22542754 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Atg7 |
autophagy related 7 |
affects response to substance |
ISO |
ATG7 protein affects the susceptibility to beta-lapachone |
CTD |
PMID:21035436 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Becn1 |
beclin 1 |
affects response to substance |
ISO |
BECN1 protein affects the susceptibility to beta-lapachone |
CTD |
PMID:21035436 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein |
CTD |
PMID:21035436 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases reduction |
ISO |
NQO1 protein results in increased reduction of beta-lapachone |
CTD |
PMID:24552538 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; delta(9)-tetrahydrocannabinolic acid promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein] |
CTD |
PMID:28861508 PMID:32510591 |
|
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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|
G |
Cnr2 |
cannabinoid receptor 2 |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein] |
CTD |
PMID:28861508 PMID:32510591 |
|
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] |
CTD |
PMID:33341026 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
delta(9)-tetrahydrocannabinolic acid results in increased expression of FOSB protein alternative form |
CTD |
PMID:18293355 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of IL6 mRNA] |
CTD |
PMID:28853159 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:32510591 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK3 protein Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:32510591 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]] |
CTD |
PMID:28853159 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression increases expression |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Rosiglitazone results in increased expression of PPARG mRNA] delta(9)-tetrahydrocannabinolic acid results in decreased expression of PPARG protein delta(9)-tetrahydrocannabinolic acid results in increased expression of PPARG mRNA |
CTD |
PMID:28853159 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
delta(9)-tetrahydrocannabinolic acid results in increased expression of PPARGC1A mRNA |
CTD |
PMID:28853159 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [TGFB1 protein results in increased expression of TNC mRNA] |
CTD |
PMID:33341026 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnc |
tenascin C |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [TGFB1 protein results in increased expression of TNC mRNA] |
CTD |
PMID:33341026 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]] |
CTD |
PMID:28853159 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression multiple interactions |
ISO |
rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein] |
CTD |
PMID:23466342 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation |
ISO |
rubimaillin results in increased phosphorylation of ACACA protein |
CTD |
PMID:23466342 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
rubimaillin results in decreased phosphorylation of AKT1 protein dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:23466342 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] |
CTD |
PMID:19716835 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
increases cleavage multiple interactions |
ISO |
rubimaillin results in increased cleavage of BID protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein] |
CTD |
PMID:19716835 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Casp12 |
caspase 12 |
increases activity multiple interactions |
ISO |
rubimaillin results in increased activity of CASP12 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein] |
CTD |
PMID:19716835 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
rubimaillin results in increased activity of CASP3 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein] |
CTD |
PMID:19716835 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases activity multiple interactions |
ISO |
rubimaillin results in increased activity of CASP7 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein] |
CTD |
PMID:19716835 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
ISO |
rubimaillin results in increased activity of CASP8 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] |
CTD |
PMID:19716835 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
ISO |
rubimaillin results in increased activity of CASP9 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein] |
CTD |
PMID:19716835 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CCNA2 protein] |
CTD |
PMID:35007525 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
rubimaillin results in decreased expression of CDK2 protein Glutathione inhibits the reaction [rubimaillin results in decreased expression of CDK2 protein] |
CTD |
PMID:35007525 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases cleavage multiple interactions |
ISO |
rubimaillin results in increased cleavage of CFLAR protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein] |
CTD |
PMID:19716835 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases expression decreases phosphorylation |
ISO |
rubimaillin results in decreased expression of CREB1 mRNA rubimaillin results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:23466342 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
rubimaillin results in increased phosphorylation of GSK3B protein |
CTD |
PMID:23466342 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation multiple interactions |
ISO |
rubimaillin results in increased phosphorylation of H2AX protein Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] |
CTD |
PMID:35007525 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation |
ISO |
rubimaillin results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:23466342 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases degradation multiple interactions |
ISO |
rubimaillin results in increased degradation of PARP1 protein BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] |
CTD |
PMID:19716835 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein |
CTD |
PMID:23466342 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases expression |
ISO |
rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein] rubimaillin results in decreased expression of RELA protein |
CTD |
PMID:23466342 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Stk11 |
serine/threonine kinase 11 |
increases phosphorylation |
ISO |
rubimaillin results in increased phosphorylation of STK11 protein |
CTD |
PMID:23466342 |
|
NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] |
CTD |
PMID:18482975 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein] |
CTD |
PMID:24040102 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein] |
CTD |
PMID:20978007 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
[Histamine co-treated with splitomicin] results in increased expression of F3 protein; splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein] |
CTD |
PMID:20978007 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 protein] |
CTD |
PMID:23525482 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases expression |
EXP |
splitomicin results in decreased expression of KCNA5 mRNA |
CTD |
PMID:25447406 |
|
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Klkb1 |
kallikrein B1 |
increases response to substance multiple interactions |
ISO |
KLKB1 gene mutant form results in increased susceptibility to splitomicin splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] |
CTD |
PMID:25339356 |
|
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG protein] |
CTD |
PMID:23525482 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] |
CTD |
PMID:22892143 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] |
CTD |
PMID:20978007 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sirt1 |
sirtuin 1 |
decreases activity decreases expression multiple interactions |
ISO EXP |
splitomicin results in decreased activity of SIRT1 protein splitomicin results in decreased expression of SIRT1 mRNA [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] |
CTD |
PMID:18482975 PMID:20978007 PMID:25447406 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Tf |
transferrin |
increases activity |
ISO |
splitomicin results in increased activity of TF protein |
CTD |
PMID:20978007 |
|
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] |
CTD |
PMID:20978007 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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