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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Ro 31-8220
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Accession:CHEBI:38912 term browser browse the term
Definition:An imidothiocarbamic ester that has formula C25H23N5O2S.
Synonyms:exact_synonym: 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
 related_synonym: 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl imidothiocarbamate;   Formula=C25H23N5O2S;   InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);   InChIKey=DSXXEELGXBCYNQ-UHFFFAOYSA-N;   SMILES=Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12
 xref: Beilstein:5366323;   CAS:125314-64-9;   LINCS:LSM-2125
 xref_mesh: MESH:C064758



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Ro 31-8220 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]
Ro 31-8220 results in decreased expression of ABCA1 mRNA
CTD PMID:15037193 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein] CTD PMID:22001173 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Ro 31-8220 results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:17561261 PMID:18054255 PMID:22001173 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] CTD PMID:22001173 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] CTD PMID:21393419 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]
CTD PMID:15522277 PMID:16280361 PMID:22138297 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 PMID:16877402 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fcer1a Fc epsilon receptor Ia multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Ro 31-8220 results in decreased expression of FOS mRNA
CTD PMID:11353138 PMID:11568973 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Ro 31-8220 results in decreased activity of GSK3B protein CTD PMID:10998351 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18048804 PMID:18357586 PMID:26275128 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] CTD PMID:18360087 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10712238 PMID:11854442 PMID:18054255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA] CTD PMID:16818790 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Ro 31-8220 results in decreased expression of JUN mRNA
Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:11353138 PMID:11568973 PMID:12169099 PMID:19002563 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] CTD PMID:11756236 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK9 protein] CTD PMID:11756236 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
Ro 31-8220 results in decreased expression of MT1 mRNA
CTD PMID:11551972 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein] CTD PMID:32416088 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nts neurotensin increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of NTS protein
Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]
CTD PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkci protein kinase C, iota decreases activity ISO Ro 31-8220 results in decreased activity of PRKCI protein CTD PMID:14511371 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD PMID:11854442 PMID:19576865 PMID:32416088 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form] CTD PMID:18986333 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnf187 ring finger protein 187 multiple interactions
decreases stability
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] CTD PMID:25851810 NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity EXP Ro 31-8220 results in decreased activity of RPS6KA5 protein CTD PMID:15522277 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA] CTD PMID:15037193 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sftpb surfactant protein B multiple interactions EXP Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein] CTD PMID:11704537 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sftpc surfactant protein C multiple interactions EXP Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein] CTD PMID:11704537 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Ro 31-8220 inhibits the reaction [decitabine results in increased expression of TNFSF10 protein] CTD PMID:17283156 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Ro 31-8220 results in decreased expression of VEGFA mRNA CTD PMID:12590138 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          sulfur atom 16418
            sulfur molecular entity 16418
              organosulfur compound 15318
                imidothiocarbamic ester 74
                  Ro 31-8220 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      dicarboxylic acids and O-substituted derivatives 10371
                                        dicarboxylic acid 10364
                                          C4-dicarboxylic acid 886
                                            butenedioic acid 589
                                              maleic acid 565
                                                maleimides 156
                                                  maleimide 77
                                                    Ro 31-8220 48
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