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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:blood substitute
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Accession:CHEBI:38849 term browser browse the term
Definition:A substance that can carry oxygen to and carbon dioxide away from the tissues when introduced into the blood stream. Blood substitutes are used to replace hemoglobin in severe hemorrhage and also to perfuse isolated organs.
Synonyms:related_synonym: artificial blood;   blood substitutes;   oxygen carrier


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perflubron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO perflubron results in increased expression of CYP11A1 mRNA CTD PMID:25871633 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO perflubron results in increased expression of CYP11B1 mRNA CTD PMID:25871633 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO perflubron results in increased expression of CYP11B2 mRNA CTD PMID:25871633 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO perflubron results in increased expression of CYP17A1 mRNA CTD PMID:25871633 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO perflubron results in increased expression of CYP19A1 mRNA CTD PMID:25871633 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO perflubron results in increased expression of HMGCR mRNA CTD PMID:25871633 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO perflubron results in increased expression of HSD17B1 mRNA CTD PMID:25871633 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO perflubron results in increased expression of HSD3B2 mRNA CTD PMID:25871633 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO perflubron results in increased expression of STAR mRNA CTD PMID:25871633 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
perfluorodecalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO perfluorodecalin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
poly(vinylpyrrolidone) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5mc2 ATP synthase membrane subunit c locus 2 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of ATP5MC2 mRNA CTD PMID:25194297 NCBI chr 7:144,264,207...144,272,578
Ensembl chr 7:144,264,199...144,272,578
JBrowse link
G Bola3 bolA family member 3 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of BOLA3 mRNA CTD PMID:25194297 NCBI chr 4:115,046,693...115,056,140
Ensembl chr 4:115,046,693...115,056,140
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Silver co-treated with Povidone] affects the expression of CASP3 protein; [Silver co-treated with Povidone] results in decreased expression of CASP3 mRNA CTD PMID:27387714 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Silver co-treated with Povidone] results in decreased expression of CDKN1A mRNA; [Silver co-treated with Povidone] results in decreased expression of CDKN1A protein CTD PMID:27387714 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of COL8A1 mRNA CTD PMID:25194297 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of COX17 mRNA CTD PMID:25194297 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of CYP1A1 mRNA CTD PMID:25194297 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dad1 defender against cell death 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of DAD1 mRNA CTD PMID:25194297 NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
JBrowse link
G Gbp2 guanylate binding protein 2 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of GBP2 mRNA CTD PMID:25194297 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:27387714 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of HMOX1 mRNA CTD PMID:25194297 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of IFIT3 mRNA CTD PMID:25194297 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Lims1 LIM zinc finger domain containing 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of LIMS1 mRNA CTD PMID:25194297 NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
JBrowse link
G Lmnb2 lamin B2 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of LMNB2 mRNA CTD PMID:25194297 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Silver Compounds co-treated with Povidone] results in increased activity of MAPK1 protein CTD PMID:21729742 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Silver Compounds co-treated with Povidone] results in increased activity of MAPK3 protein CTD PMID:21729742 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Silver co-treated with Povidone] affects the expression of MDM2 protein; [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Silver analog co-treated with Povidone] affects the expression of MT1A mRNA CTD PMID:25194297 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nfix nuclear factor I X multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of NFIX mRNA CTD PMID:25194297 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of NQO1 mRNA CTD PMID:25194297 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrm nurim multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of NRM mRNA CTD PMID:25194297 NCBI chr20:3,397,834...3,402,264
Ensembl chr20:3,397,834...3,401,315
JBrowse link
G Nuak2 NUAK family kinase 2 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of NUAK2 mRNA CTD PMID:25194297 NCBI chr13:49,092,306...49,109,055
Ensembl chr13:49,092,306...49,109,050
JBrowse link
G Ocln occludin affects expression ISO Povidone affects the expression of OCLN mRNA CTD PMID:19729060 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Prpf38b pre-mRNA processing factor 38B multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of PRPF38B mRNA CTD PMID:25194297 NCBI chr 2:211,706,245...211,715,271
Ensembl chr 2:211,706,228...211,715,311
JBrowse link
G Prr13 proline rich 13 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of PRR13 mRNA CTD PMID:25194297 NCBI chr 7:144,064,931...144,068,235
Ensembl chr 7:144,064,931...144,098,101
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of PSENEN mRNA CTD PMID:25194297 NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of PTGS2 mRNA CTD PMID:25194297 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Silver Compounds co-treated with Povidone] results in increased activity of PTK2 protein CTD PMID:21729742 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rab14 RAB14, member RAS oncogene family multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of RAB14 mRNA CTD PMID:25194297 NCBI chr 3:14,373,270...14,395,357
Ensembl chr 3:14,373,275...14,395,362
JBrowse link
G Rbm25l1 RNA binding motif protein 25-like 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of RBM25L1 mRNA CTD PMID:25194297 NCBI chr10:10,457,316...10,460,540
Ensembl chr10:10,457,320...10,460,756
JBrowse link
G Samd9 sterile alpha motif domain containing 9 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of SAMD9L mRNA CTD PMID:25194297 NCBI chr 4:28,304,967...28,324,637
Ensembl chr 4:28,305,002...28,310,178
JBrowse link
G Selenow selenoprotein W multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of SELENOW mRNA CTD PMID:25194297 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of SLC5A3 mRNA CTD PMID:25194297 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Silver co-treated with Povidone] results in increased expression of SOD2 mRNA; [Silver co-treated with Povidone] results in increased expression of SOD2 protein CTD PMID:27387714 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sparc secreted protein acidic and cysteine rich multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of SPARC mRNA CTD PMID:25194297 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of STAT2 mRNA CTD PMID:25194297 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Sv2b synaptic vesicle glycoprotein 2b multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of SV2B mRNA CTD PMID:25194297 NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of TIPARP mRNA CTD PMID:25194297 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of TMTC3 mRNA CTD PMID:25194297 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Silver co-treated with Povidone] affects the phosphorylation of TP53 protein; [Silver co-treated with Povidone] results in decreased expression of TP53 mRNA; [Silver co-treated with Povidone] results in decreased expression of TP53 protein CTD PMID:27387714 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trappc1 trafficking protein particle complex 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in decreased expression of TRAPPC1 mRNA CTD PMID:25194297 NCBI chr10:55,924,996...55,926,582
Ensembl chr10:55,924,938...55,926,783
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Silver Compounds co-treated with Povidone] results in increased expression of VEGFA protein CTD PMID:21729742 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of WDFY1 mRNA CTD PMID:25194297 NCBI chr 9:85,477,070...85,528,885
Ensembl chr 9:85,475,841...85,528,869
JBrowse link
G Zfhx3 zinc finger homeobox 3 multiple interactions EXP [Silver analog co-treated with Povidone] results in increased expression of ZFHX3 mRNA CTD PMID:25194297 NCBI chr19:42,753,983...42,925,794
Ensembl chr19:42,758,127...42,920,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          blood substitute 53
            1,8-dichloro-perfluorooctane 0
            bis(perfluorobutyl)ethene + 0
            perflubron 9
            perfluoro-4-methylquinolizidine 0
            perfluoro-N-(4-methylcyclohexyl)piperidine 0
            perfluoro-N-methyldecahydroisoquinoline 0
            perfluorodecalin 1
            perfluorotributylamine 0
            perfluorotripropylamine 0
            poly(vinylpyrrolidone) + 43
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.