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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:profenofos
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Accession:CHEBI:38845 term browser browse the term
Definition:An organophosphate insecticide that has formula C11H15BrClO3PS.
Synonyms:exact_synonym: O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
 related_synonym: Curacron;   Formula=C11H15BrClO3PS;   InChI=1S/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3;   InChIKey=QYMMJNLHFKGANY-UHFFFAOYSA-N;   O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl thiophosphate;   Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester;   SMILES=CCCSP(=O)(OCC)Oc1ccc(Br)cc1Cl
 xref: Beilstein:2150258;   CAS:41198-08-7;   KEGG:C18404
 xref_mesh: MESH:C024273
 xref: PPDB:538


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profenofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
profenofos results in decreased activity of ACHE protein
profenofos metabolite results in decreased activity of ACHE protein
CTD PMID:16978018 PMID:21251949 PMID:30625376 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin affects binding ISO profenofos binds to ALB protein CTD PMID:28407546 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression EXP profenofos results in decreased expression of ARID1A mRNA CTD PMID:17569032 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO profenofos results in decreased activity of BCHE protein CTD PMID:9890196 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 protein CTD PMID:21987380 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression EXP profenofos results in increased expression of CAT mRNA CTD PMID:23495063 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrdl1 chordin-like 1 decreases expression EXP profenofos results in decreased expression of CHRDL1 mRNA CTD PMID:17569032 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP11A1 mRNA CTD PMID:17569032 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP17A1 mRNA CTD PMID:17569032 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression EXP profenofos results in decreased expression of CYP19A1 mRNA CTD PMID:18828448 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO profenofos results in decreased activity of CYP1A1 protein CTD PMID:20183062 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO profenofos results in increased expression of CYP1A2 mRNA
profenofos results in decreased activity of CYP1A2 protein
CTD PMID:20183062 PMID:22310298 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases metabolic processing
multiple interactions
decreases activity
ISO profenofos results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of profenofos
[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
profenofos results in decreased activity of CYP2B6 protein
CTD PMID:22310298 PMID:23415833 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP profenofos results in decreased expression of CYP2C11 mRNA; profenofos results in decreased expression of CYP2C11 protein CTD PMID:18828448 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of profenofos
[CYP2C19 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
CTD PMID:23415833 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
profenofos results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases activity
increases metabolic processing
increases expression
EXP
ISO
profenofos results in decreased expression of CYP3A2 mRNA; profenofos results in decreased expression of CYP3A2 protein
[CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
profenofos results in increased activity of CYP3A4 protein
profenofos results in increased expression of CYP3A4 mRNA
CTD PMID:18828448 PMID:22310298 PMID:23415833 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO profenofos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO profenofos results in decreased activity of FAAH protein CTD PMID:11350214
G Gch1 GTP cyclohydrolase 1 decreases expression EXP profenofos results in decreased expression of GCH1 mRNA CTD PMID:17569032 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP profenofos results in decreased expression of GRIN2A mRNA CTD PMID:17569032 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Hao2 hydroxyacid oxidase 2 increases expression EXP profenofos results in increased expression of HAO2 mRNA CTD PMID:17569032 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hp haptoglobin increases expression EXP profenofos results in increased expression of HP mRNA CTD PMID:17569032 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Lamc1 laminin subunit gamma 1 decreases expression EXP profenofos results in decreased expression of LAMC1 mRNA CTD PMID:17569032 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression EXP profenofos results in decreased expression of MCAM mRNA CTD PMID:17569032 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
JBrowse link
G Ms4a6a membrane spanning 4-domains A6A increases expression EXP profenofos results in increased expression of MS4A6A mRNA CTD PMID:17569032 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758
JBrowse link
G Myo1d myosin ID decreases expression EXP profenofos results in decreased expression of MYO1D mRNA CTD PMID:17569032 NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO profenofos results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Nell1 neural EGFL like 1 decreases expression EXP profenofos results in decreased expression of NELL1 mRNA CTD PMID:17569032 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO profenofos results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 decreases expression EXP profenofos results in decreased expression of NRBF2 mRNA CTD PMID:17569032 NCBI chr20:21,308,606...21,326,878
Ensembl chr20:21,308,576...21,326,818
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 increases expression EXP profenofos results in increased expression of PDZRN3 mRNA CTD PMID:17569032 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP profenofos results in increased expression of RGS2 mRNA CTD PMID:17569032 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rwdd2b RWD domain containing 2B increases expression EXP profenofos results in increased expression of RWDD2B mRNA CTD PMID:17569032 NCBI chr11:26,665,877...26,677,986
Ensembl chr11:26,665,877...26,674,603
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP profenofos results in decreased expression of SLC1A1 mRNA CTD PMID:17569032 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP profenofos results in increased expression of SOD1 mRNA CTD PMID:23495063 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP profenofos results in increased expression of STAR mRNA CTD PMID:17569032 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          profenofos 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              organic thiophosphate 3715
                                                profenofos 37
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