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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pirimiphos-methyl
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Accession:CHEBI:38843 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.
Synonyms:exact_synonym: O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl phosphorothioate
 related_synonym: Formula=C11H20N3O3PS;   InChI=1S/C11H20N3O3PS/c1-6-14(7-2)11-12-9(3)8-10(13-11)17-18(19,15-4)16-5/h8H,6-7H2,1-5H3;   InChIKey=QHOQHJPRIBSPCY-UHFFFAOYSA-N;   O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl thiophosphate;   Pirimifosmethyl;   Pirimiphosmethyl;   Pyrimiphos methyl;   SMILES=CCN(CC)c1nc(C)cc(OP(=S)(OC)OC)n1
 xref: Beilstein:755726;   CAS:29232-93-7;   KEGG:C18403
 xref_mesh: MESH:C014153
 xref: PMID:23343221;   PMID:24476070;   PMID:24685163;   PMID:24711991;   PPDB:532;   Reaxys:755726;   Wikipedia:Pirimiphos-methyl


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pirimiphos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO pirimiphos methyl results in decreased activity of ACHE protein CTD PMID:8658539 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases activity EXP pirimiphos methyl results in decreased activity of ANPEP protein CTD PMID:9204212 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Ar androgen receptor multiple interactions ISO pirimiphos methyl inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ctsc cathepsin C decreases activity
increases activity		 EXP pirimiphos methyl results in decreased activity of CTSC protein
pirimiphos methyl results in increased activity of CTSC protein		 CTD PMID:9204212 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ctsd cathepsin D decreases activity
increases activity		 EXP pirimiphos methyl results in decreased activity of CTSD protein
pirimiphos methyl results in increased activity of CTSD protein		 CTD PMID:9204212 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsl cathepsin L increases activity EXP pirimiphos methyl results in increased activity of CTSL protein CTD PMID:9204212 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dpp6 dipeptidyl peptidase like 6 decreases activity EXP pirimiphos methyl results in decreased activity of DPP6 protein CTD PMID:9204212 NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO pirimiphos methyl results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pirimiphos methyl binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases activity ISO pirimiphos methyl results in increased activity of NR4A2 protein CTD PMID:20143881 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases activity ISO pirimiphos methyl results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prep prolyl endopeptidase decreases activity EXP pirimiphos methyl results in decreased activity of PREP protein CTD PMID:9204212 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [pirimiphos methyl binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rnpep arginyl aminopeptidase decreases activity EXP pirimiphos methyl results in decreased activity of RNPEP protein CTD PMID:9204212 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases activity EXP pirimiphos methyl results in decreased activity of TPP1 protein CTD PMID:9204212 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        agrochemical 16259
          pirimiphos-methyl 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11427
                                      phosphoric acid 11417
                                        phosphoric acid derivative 11226
                                          phosphate 11225
                                            organic phosphate 11225
                                              organic thiophosphate 8611
                                                pirimiphos-methyl 15
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