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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pirimiphos-methyl
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Accession:CHEBI:38843 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.
Synonyms:exact_synonym: O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl phosphorothioate
 related_synonym: Formula=C11H20N3O3PS;   InChI=1S/C11H20N3O3PS/c1-6-14(7-2)11-12-9(3)8-10(13-11)17-18(19,15-4)16-5/h8H,6-7H2,1-5H3;   InChIKey=QHOQHJPRIBSPCY-UHFFFAOYSA-N;   O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl thiophosphate;   Pirimifosmethyl;   Pirimiphosmethyl;   Pyrimiphos methyl;   SMILES=CCN(CC)c1nc(C)cc(OP(=S)(OC)OC)n1
 xref: Beilstein:755726;   CAS:29232-93-7;   KEGG:C18403
 xref_mesh: MESH:C014153
 xref: PMID:23343221;   PMID:24476070;   PMID:24685163;   PMID:24711991;   PPDB:532;   Reaxys:755726;   Wikipedia:Pirimiphos-methyl



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pirimiphos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO pirimiphos methyl results in decreased activity of ACHE protein CTD PMID:8658539 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases activity EXP pirimiphos methyl results in decreased activity of ANPEP protein CTD PMID:9204212 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Ar androgen receptor multiple interactions ISO pirimiphos methyl inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ctsc cathepsin C decreases activity
increases activity
EXP pirimiphos methyl results in decreased activity of CTSC protein
pirimiphos methyl results in increased activity of CTSC protein
CTD PMID:9204212 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsd cathepsin D decreases activity
increases activity
EXP pirimiphos methyl results in decreased activity of CTSD protein
pirimiphos methyl results in increased activity of CTSD protein
CTD PMID:9204212 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L increases activity EXP pirimiphos methyl results in increased activity of CTSL protein CTD PMID:9204212 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Dpp6 dipeptidyl peptidase like 6 decreases activity EXP pirimiphos methyl results in decreased activity of DPP6 protein CTD PMID:9204212 NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO pirimiphos methyl results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pirimiphos methyl binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases activity ISO pirimiphos methyl results in increased activity of NR4A2 protein CTD PMID:20143881 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Prep prolyl endopeptidase decreases activity EXP pirimiphos methyl results in decreased activity of PREP protein CTD PMID:9204212 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [pirimiphos methyl binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rnpep arginyl aminopeptidase decreases activity EXP pirimiphos methyl results in decreased activity of RNPEP protein CTD PMID:9204212 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases activity EXP pirimiphos methyl results in decreased activity of TPP1 protein CTD PMID:9204212 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        agrochemical 15185
          pirimiphos-methyl 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              oxoacid 18466
                                pnictogen oxoacid 10732
                                  phosphorus oxoacid 9727
                                    phosphoric acids 8535
                                      phosphoric acid 8535
                                        phosphoric acid derivative 8241
                                          phosphate 8241
                                            organic phosphate 8240
                                              organic thiophosphate 3816
                                                pirimiphos-methyl 14
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