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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(hydroxyimino)(phenyl)acetonitrile
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Accession:CHEBI:38842 term browser browse the term
Definition:A ketoxime that has formula C8H6N2O.
Synonyms:related_synonym: (Hydroxyimino)phenylacetonitrile;   Formula=C8H6N2O;   InChI=1S/C8H6N2O/c9-6-8(10-11)7-4-2-1-3-5-7/h1-5,11H/b10-8-;   InChIKey=MJCQFBKIFDVTTR-NTMALXAHSA-N;   SMILES=O\\N=C(\\C#N)c1ccccc1;   alpha-(hydroxyimino)benzeneacetonitrile
 xref: Beilstein:2690170;   CAS:825-52-5


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phoxim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO		 phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein CTD PMID:15793557 PMID:33497710 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 affects expression ISO phoxim affects the expression of ARL6IP5 protein CTD PMID:15799245 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of BCHE protein CTD PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions		 ISO phoxim results in increased expression of CEBPA protein
Fulvestrant inhibits the reaction [phoxim results in increased expression of CEBPA protein]		 CTD PMID:33872936 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cldn4 claudin 4 decreases expression
multiple interactions		 EXP phoxim results in decreased expression of CLDN4 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]		 CTD PMID:30003487 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP phoxim results in increased expression of CYP2B1 mRNA CTD PMID:36356836 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding		 ISO phoxim binds to and results in increased activity of ESR1 protein
phoxim binds to ESR1 protein		 CTD PMID:33049310 PMID:33872936 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO phoxim results in increased expression of FAS mRNA
Fulvestrant inhibits the reaction [phoxim results in increased expression of FAS mRNA]		 CTD PMID:33872936 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions		 EXP phoxim results in increased expression of GPX2 mRNA
Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]		 CTD PMID:30003487 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phoxim results in decreased expression of IL1B mRNA CTD PMID:30003487 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 EXP phoxim results in decreased expression of IL6 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]		 CTD PMID:30003487 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions		 ISO phoxim results in increased expression of LPL mRNA
Fulvestrant inhibits the reaction [phoxim results in increased expression of LPL mRNA]		 CTD PMID:33872936 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP phoxim results in increased expression of NFE2L2 mRNA CTD PMID:30003487 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phoxim binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin multiple interactions
decreases expression		 EXP Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA] CTD PMID:30003487 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Plin1 perilipin 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [phoxim results in increased expression of PLIN1 protein]; tolclofos-methyl inhibits the reaction [phoxim results in increased expression of PLIN1 protein] CTD PMID:33872936 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO phoxim binds to and results in increased activity of PPARG protein
Fulvestrant inhibits the reaction [phoxim results in increased expression of PPARG protein]; phoxim binds to and results in increased activity of PPARG protein		 CTD PMID:33049310 PMID:33872936 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO phoxim binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein]
phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein		 CTD PMID:30003487 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO phoxim metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        NMR chemical shift reference compound 17936
          acetonitrile 31
            (hydroxyimino)(phenyl)acetonitrile 22
              phoxim 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            one-carbon compound 17844
                              hydrogen cyanide 4788
                                cyanides 4771
                                  nitrile 4563
                                    aliphatic nitrile 2198
                                      acetonitrile 31
                                        (hydroxyimino)(phenyl)acetonitrile 22
                                          phoxim 22
paths to the root