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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corilagin
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Accession:CHEBI:3884 term browser browse the term
Definition:An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core.
Synonyms:exact_synonym: 3-O,6-O-[carbonyl(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)carbonyl]-1-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose
 related_synonym: (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose);   1-O-galloyl-3,6-hexahydroxydiphenic acid-beta-D-glucopyranose;   Formula=C27H22O18;   InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1;   InChIKey=TUSDEZXZIZRFGC-XIGLUPEJSA-N;   SMILES=O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]1[C@@H](O)[C@@H](O2)OC(=O)c1cc(O)c(O)c(O)c1;   gallotannin
 xref: Beilstein:76352;   CAS:23094-69-1;   KEGG:C10219;   KNApSAcK:C00002915
 xref_mesh: MESH:C049096
 xref: PMID:18486919



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corilagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]] CTD PMID:37394652 NCBI chr20:3,651,435...3,657,341 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
EXP
ISO
corilagin inhibits the reaction [Doxorubicin results in increased expression of AKT1 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]
corilagin results in decreased expression of AKT1 protein
CTD PMID:34369273 PMID:34605098 PMID:35084093 PMID:35103375 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] CTD PMID:37394652 NCBI chr 7:113,684,681...113,686,739 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein] CTD PMID:34605098 PMID:35103375 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein] CTD PMID:34605098 PMID:35103375 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bsg basigin multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA] CTD PMID:35103375 NCBI chr 7:10,643,788...10,651,005 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
corilagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
CTD PMID:34605098 PMID:35103375 PMID:37394652 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp9 caspase 9 multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein] CTD PMID:35103375
G Cat catalase multiple interactions EXP
ISO
corilagin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein]; corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]
CTD PMID:30582900 PMID:34605098 PMID:35103375 PMID:35307913 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] CTD PMID:37394652 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 4:104,363,838...104,425,271 JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein] CTD PMID:34369273 NCBI chr 5:142,651,962...142,658,707 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] CTD PMID:35307913 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA CTD PMID:35307913 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA] CTD PMID:35103375 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA] CTD PMID:35103375 NCBI chr12:11,009,236...11,015,941 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased activity of HMGCR protein] CTD PMID:34605098 NCBI chr 2:29,732,163...29,754,276 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]] CTD PMID:35307913 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]] CTD PMID:37394652 NCBI chr 3:38,453,016...38,457,475 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]] CTD PMID:37394652 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
corilagin inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]
corilagin results in decreased expression of IL6 protein
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
CTD PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ins1 insulin 1 multiple interactions EXP corilagin inhibits the reaction [Streptozocin results in increased secretion of INS1 protein] CTD PMID:30582900 NCBI chr 1:261,186,119...261,186,686 JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA] CTD PMID:35103375 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Mb myoglobin multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of MB protein] CTD PMID:34369273 NCBI chr 7:110,640,511...110,647,742 JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:35307913 NCBI chr18:76,321,386...76,430,997 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA] CTD PMID:35307913 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO corilagin results in decreased expression of NFKB1 protein CTD PMID:35084093 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] CTD PMID:37394652 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO corilagin results in decreased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
CTD PMID:35084093 PMID:37394652 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:34369273 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells RGD PMID:29235094 RGD:15042872 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA] CTD PMID:35103375 NCBI chr 6:54,494,247...54,529,563 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of PPARG protein] CTD PMID:34605098 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO corilagin results in decreased expression of PTGS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]
CTD PMID:35084093 PMID:37394652 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]] CTD PMID:37394652 NCBI chr 1:192,032,124...192,033,419 JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA] CTD PMID:35103375 NCBI chr10:106,212,679...106,222,564 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:34369273 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of TLR2 mRNA]; corilagin inhibits the reaction [Morphine results in increased expression of TLR2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 2:171,499,189...171,504,831 JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
decreases expression
ISO
EXP
corilagin results in decreased secretion of TNF protein
corilagin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
corilagin results in decreased expression of TNF protein
corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]
CTD PMID:12628509 PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]] CTD PMID:35307913 NCBI chr15:60,083,008...60,114,479 JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP corilagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:34369273 NCBI chr 1:78,342,571...78,346,255 JBrowse link

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  CHEBI ontology 19898
    role 19869
      chemical role 19500
        antioxidant 16189
          corilagin 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      aromatic carboxylic acid 12748
                                        benzoic acids 12726
                                          benzoic acid 5521
                                            hydroxybenzoic acid 4996
                                              trihydroxybenzoic acid 2758
                                                gallic acid 2741
                                                  ellagic acid 170
                                                    ellagitannin 41
                                                      corilagin 41
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