CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: nonionic surfactant
Accession: CHEBI:38828
browse the term
Definition: A surfactant with an uncharged hydrophilic headgroup.
Synonyms: related_synonym: non-ionic surfactant; nonionic surfactants
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases secretion multiple interactions
EXP
Poloxamer results in decreased secretion of ADIPOQ protein carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]
CTD
PMID:29071762
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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Afp
alpha-fetoprotein
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]
CTD
PMID:32961231
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
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Casp3
caspase 3
increases expression multiple interactions
EXP
Poloxamer results in increased expression of CASP3 protein carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]
CTD
PMID:29071762 PMID:32961231
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions decreases activity
EXP
carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]
CTD
PMID:29071762
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Ccnd1
cyclin D1
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
CTD
PMID:32961231
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Cd68
Cd68 molecule
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA]
CTD
PMID:32169474
NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697
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Ckm
creatine kinase, M-type
multiple interactions increases secretion
EXP
carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein]
CTD
PMID:29071762
NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720
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Csf1r
colony stimulating factor 1 receptor
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA]
CTD
PMID:32169474
NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415
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Csf2ra
colony stimulating factor 2 receptor subunit alpha
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA]
CTD
PMID:32169474
NCBI chr14:113,219...118,808
Ensembl chr14:89,172...103,128
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Ctnnb1
catenin beta 1
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
CTD
PMID:32961231
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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Dvl2
dishevelled segment polarity protein 2
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]
CTD
PMID:32961231
NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820
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Hes1
hes family bHLH transcription factor 1
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]
CTD
PMID:32961231
NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[nickel monoxide co-treated with Poloxamer] results in increased expression of HMOX1 mRNA
CTD
PMID:25964212
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA]
CTD
PMID:32169474
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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Icam2
intercellular adhesion molecule 2
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA]
CTD
PMID:32169474
NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,308,538...91,315,293
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Il1b
interleukin 1 beta
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]
CTD
PMID:32169474
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA]
CTD
PMID:32169474
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Itgam
integrin subunit alpha M
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA]
CTD
PMID:32169474
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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Lep
leptin
multiple interactions increases secretion
EXP
carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein]
CTD
PMID:29071762
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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Lrp5
LDL receptor related protein 5
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]]
CTD
PMID:32961231
NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581
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Lrp6
LDL receptor related protein 6
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
CTD
PMID:32961231
NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497
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Mb
myoglobin
multiple interactions increases secretion
EXP
carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein]
CTD
PMID:29071762
NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383
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Notch1
notch receptor 1
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]
CTD
PMID:32961231
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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Pnlip
pancreatic lipase
decreases activity
ISO
Poloxamer results in decreased activity of PNLIP protein
CTD
PMID:16872557
NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Poloxamer inhibits the reaction [Nanotubes, Carbon inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]]
CTD
PMID:17709331
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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Tnf
tumor necrosis factor
multiple interactions
ISO
Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]
CTD
PMID:32169474
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Wnt3a
Wnt family member 3A
multiple interactions
EXP
Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]
CTD
PMID:32961231
NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324
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Hmox1
heme oxygenase 1
increases expression
ISO
polysorbate 40 results in increased expression of HMOX1 mRNA
CTD
PMID:17225922
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Cnfn
cornifelin
increases expression
ISO
Octoxynol results in increased expression of CNFN mRNA; Octoxynol results in increased expression of CNFN protein
CTD
PMID:25377654
NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747
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Egr1
early growth response 1
increases expression
ISO
Octoxynol results in increased expression of EGR1 mRNA
CTD
PMID:25377654
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
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Ezr
ezrin
increases expression
ISO
Octoxynol results in increased expression of EZR mRNA
CTD
PMID:29893927
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fn1
fibronectin 1
decreases expression
ISO
Octoxynol results in decreased expression of FN1 mRNA
CTD
PMID:25377654
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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Il1a
interleukin 1 alpha
increases secretion
ISO
Octoxynol results in increased secretion of IL1A protein
CTD
PMID:23999410
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Octoxynol results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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LOC120100208
small nucleolar RNA SNORA71
decreases expression
ISO
Octoxynol results in decreased expression of SNORA71D mRNA
CTD
PMID:25377654
NCBI chr 1:232,131,169...232,131,300
Ensembl chr 1:232,131,169...232,131,300
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Scd
stearoyl-CoA desaturase
increases expression
ISO
Octoxynol results in increased expression of SCD mRNA
CTD
PMID:29155129
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
Octoxynol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]
CTD
PMID:17038422
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20856
role
20816
chemical role
20394
emulsifier
7613
surfactant
7613
nonionic surfactant
36
(9Z)-octadecen-1-ol +
0
1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexadecane
0
1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctadec-7-ene +
0
11-(perfluorohexyl)undecyl dimorpholinophosphinate
0
11-(perfluorooctyl)undecyl dimorpholinophosphinate
0
2-(perfluorohexyl)ethyl dimorpholinophosphinate
0
2-(perfluorooctyl)ethyl dimorpholinophosphinate
0
2-O-alpha-L-rhamnosyl-alpha-L-rhamnosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid
0
2-hydroxyethyl octadecanoate
0
L-rhamnosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid
0
Triton X-100
9
laureth-5
0
perfluorohexyloctane
0
pluronic P-123
27
polidocanol
0
polyoxyl 40 stearate
0
polysorbate 20
0
polysorbate 40
1
polysorbate 60
0
polysorbate 80
0
tergitol +
0
tergitol NP-9
0