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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nonionic surfactant
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Accession:CHEBI:38828 term browser browse the term
Definition:A surfactant with an uncharged hydrophilic headgroup.
Synonyms:related_synonym: non-ionic surfactant;   nonionic surfactants


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pluronic P-123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases secretion
multiple interactions 		EXP Poloxamer results in decreased secretion of ADIPOQ protein
carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein] 		CTD PMID:29071762 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		EXP Poloxamer results in increased expression of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein] 		CTD PMID:29071762 PMID:32961231 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein] CTD PMID:29071762 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]] CTD PMID:32961231 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions
increases secretion 		EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein] CTD PMID:29071762 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr14:113,219...118,808
Ensembl chr14:89,172...103,128 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]] CTD PMID:32961231 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]] CTD PMID:32961231 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]] CTD PMID:32961231 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nickel monoxide co-treated with Poloxamer] results in increased expression of HMOX1 mRNA CTD PMID:25964212 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,308,538...91,315,293 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA] CTD PMID:32169474 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:32169474 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Lep leptin multiple interactions
increases secretion 		EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] CTD PMID:32961231 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]] CTD PMID:32961231 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Mb myoglobin multiple interactions
increases secretion 		EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein] CTD PMID:29071762 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Notch1 notch receptor 1 multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Pnlip pancreatic lipase decreases activity ISO Poloxamer results in decreased activity of PNLIP protein CTD PMID:16872557 NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Poloxamer inhibits the reaction [Nanotubes, Carbon inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]] CTD PMID:17709331 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA] CTD PMID:32169474 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]] CTD PMID:32961231 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
polysorbate 40 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO polysorbate 40 results in increased expression of HMOX1 mRNA CTD PMID:17225922 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
Triton X-100 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnfn cornifelin increases expression ISO Octoxynol results in increased expression of CNFN mRNA; Octoxynol results in increased expression of CNFN protein CTD PMID:25377654 NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Octoxynol results in increased expression of EGR1 mRNA CTD PMID:25377654 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ezr ezrin increases expression ISO Octoxynol results in increased expression of EZR mRNA CTD PMID:29893927 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Octoxynol results in decreased expression of FN1 mRNA CTD PMID:25377654 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO Octoxynol results in increased secretion of IL1A protein CTD PMID:23999410 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Octoxynol results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G LOC120100208 small nucleolar RNA SNORA71 decreases expression ISO Octoxynol results in decreased expression of SNORA71D mRNA CTD PMID:25377654 NCBI chr 1:232,131,169...232,131,300
Ensembl chr 1:232,131,169...232,131,300 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Octoxynol results in increased expression of SCD mRNA CTD PMID:29155129 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Octoxynol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17038422 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      chemical role 20394
        emulsifier 7613
          surfactant 7613
            nonionic surfactant 36
              (9Z)-octadecen-1-ol + 0
              1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexadecane 0
              1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctadec-7-ene + 0
              11-(perfluorohexyl)undecyl dimorpholinophosphinate 0
              11-(perfluorooctyl)undecyl dimorpholinophosphinate 0
              2-(perfluorohexyl)ethyl dimorpholinophosphinate 0
              2-(perfluorooctyl)ethyl dimorpholinophosphinate 0
              2-O-alpha-L-rhamnosyl-alpha-L-rhamnosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid 0
              2-hydroxyethyl octadecanoate 0
              L-rhamnosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid 0
              Triton X-100 9
              laureth-5 0
              perfluorohexyloctane 0
              pluronic P-123 27
              polidocanol 0
              polyoxyl 40 stearate 0
              polysorbate 20 0
              polysorbate 40 1
              polysorbate 60 0
              polysorbate 80 0
              tergitol + 0
              tergitol NP-9 0
paths to the root