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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diazepane
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Accession:CHEBI:38823 term browser browse the term
Synonyms:related_synonym: diazepanes


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5-(1,4-diazepane-1-sulfonyl)isoquinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO fasudil results in decreased expression of ACTA2 mRNA CTD PMID:22465603 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP fasudil results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17761835 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arg1 arginase 1 increases expression EXP fasudil results in increased expression of ARG1 protein CTD PMID:30462329 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 decreases expression ISO fasudil results in decreased expression of ARHGEF11 mRNA; fasudil results in decreased expression of ARHGEF11 protein CTD PMID:26172442 NCBI chr 2:186,979,850...187,102,523
Ensembl chr 2:186,980,793...187,101,768
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP fasudil inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; fasudil inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:22429817, PMID:30088170 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP fasudil inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
fasudil results in increased expression of BCL2 protein
CTD PMID:17761835, PMID:22429817, PMID:30088170 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein CTD PMID:31935364 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp3 caspase 3 multiple interactions EXP fasudil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] CTD PMID:17761835, PMID:30088170 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cfl1 cofilin 1 decreases expression
multiple interactions
ISO
EXP
fasudil results in decreased expression of CFL1 mRNA
fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of CFL1 protein]
fasudil results in decreased expression of and results in decreased phosphorylation of CFL1 protein
CTD PMID:22062134, PMID:26172442 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO fasudil results in decreased expression of COL1A1 mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA
CTD PMID:22465603, PMID:31935364 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO fasudil results in decreased expression of COL3A1 mRNA CTD PMID:22465603 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:23376009 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP [fasudil co-treated with Methylmercury Compounds] results in increased expression of and results in increased phosphorylation of GAP43 protein CTD PMID:30462329 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:30831131 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO fasudil affects the expression of HMOX1 protein CTD PMID:26120273 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:23376009 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 increases expression EXP fasudil results in increased expression of IL10 protein CTD PMID:30462329 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 multiple interactions EXP fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL1B protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
CTD PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL6 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL6 protein]
CTD PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Limk2 LIM domain kinase 2 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] CTD PMID:22062134 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO fasudil results in decreased expression of MAP3K7 protein CTD PMID:22465603 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP fasudil inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein] CTD PMID:20869980 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mmp8 matrix metallopeptidase 8 affects expression ISO fasudil affects the expression of MMP8 mRNA CTD PMID:26120273 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects expression ISO fasudil affects the expression of MMP9 mRNA CTD PMID:26120273 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein] CTD PMID:30924981 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO fasudil results in decreased expression of MYH7 mRNA CTD PMID:22465603 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
fasudil inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]
CTD PMID:23376009, PMID:30924981 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of NOS2 protein] CTD PMID:30462329 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein] CTD PMID:16452496 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO fasudil results in decreased expression of NPPA mRNA CTD PMID:22465603 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO fasudil results in decreased expression of NPPB mRNA CTD PMID:22465603 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pkn2 protein kinase N2 decreases activity ISO fasudil results in decreased activity of PKN2 protein CTD PMID:10998351 NCBI chr 2:248,735,699...248,840,735
Ensembl chr 2:248,735,699...248,840,735
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP fasudil inhibits the reaction [Paraquat results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form] CTD PMID:22429817, PMID:30088170 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of RELA protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
CTD PMID:23376009, PMID:30462329, PMID:30924981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rho rhodopsin multiple interactions ISO
EXP
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]
fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]; fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
CTD PMID:30088170, PMID:30924981 NCBI chr 4:147,832,136...147,837,298
Ensembl chr 4:147,832,136...147,837,298
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO fasudil results in decreased expression of RHOA mRNA; fasudil results in decreased expression of RHOA protein CTD PMID:26172442 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression
multiple interactions
ISO
EXP
fasudil results in decreased expression of ROCK1 mRNA; fasudil results in decreased expression of ROCK1 protein
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]
CTD PMID:20037814, PMID:22429817, PMID:23376009, PMID:26172442, PMID:30088170, PMID:30924981 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity
multiple interactions
EXP
ISO
fasudil results in decreased activity of ROCK2 protein
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein]
CTD PMID:10998351, PMID:30924981 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases activity ISO fasudil results in decreased activity of RPS6KA1 protein CTD PMID:10998351 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO fasudil results in decreased activity of RPS6KA5 protein CTD PMID:10998351 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO fasudil results in decreased activity of RPS6KB1 protein CTD PMID:10998351 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein CTD PMID:31935364 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO fasudil results in increased expression of SLC12A2 protein CTD PMID:21474433 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Syp synaptophysin multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:22062134 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
fasudil results in decreased expression of TGFB1 protein
fasudil inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
CTD PMID:22465603, PMID:23376009 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO fasudil affects the expression of TIMP1 mRNA CTD PMID:22465603 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP
ISO
fasudil inhibits the reaction [Paraquat results in decreased expression of TJP1 protein] CTD PMID:30088170 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions
ISO
EXP
fasudil affects the expression of TNF mRNA
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of TNF protein]
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD PMID:26120273, PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:30831131 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression ISO fasudil affects the expression of VEGFA mRNA CTD PMID:26120273 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
fasudil hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO fasudil results in decreased expression of ACTA2 mRNA CTD PMID:22465603 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP fasudil results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17761835 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arg1 arginase 1 increases expression EXP fasudil results in increased expression of ARG1 protein CTD PMID:30462329 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 decreases expression ISO fasudil results in decreased expression of ARHGEF11 mRNA; fasudil results in decreased expression of ARHGEF11 protein CTD PMID:26172442 NCBI chr 2:186,979,850...187,102,523
Ensembl chr 2:186,980,793...187,101,768
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP fasudil inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; fasudil inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:22429817, PMID:30088170 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP fasudil inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
fasudil results in increased expression of BCL2 protein
CTD PMID:17761835, PMID:22429817, PMID:30088170 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein CTD PMID:31935364 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp3 caspase 3 multiple interactions EXP fasudil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] CTD PMID:17761835, PMID:30088170 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cfl1 cofilin 1 multiple interactions
decreases expression
EXP
ISO
fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of CFL1 protein]
fasudil results in decreased expression of CFL1 mRNA
fasudil results in decreased expression of and results in decreased phosphorylation of CFL1 protein
CTD PMID:22062134, PMID:26172442 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO fasudil results in decreased expression of COL1A1 mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA
CTD PMID:22465603, PMID:31935364 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO fasudil results in decreased expression of COL3A1 mRNA CTD PMID:22465603 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:23376009 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP [fasudil co-treated with Methylmercury Compounds] results in increased expression of and results in increased phosphorylation of GAP43 protein CTD PMID:30462329 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:30831131 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO fasudil affects the expression of HMOX1 protein CTD PMID:26120273 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:23376009 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 increases expression EXP fasudil results in increased expression of IL10 protein CTD PMID:30462329 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 multiple interactions EXP fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL1B protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
CTD PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL6 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL6 protein]
CTD PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Limk2 LIM domain kinase 2 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] CTD PMID:22062134 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO fasudil results in decreased expression of MAP3K7 protein CTD PMID:22465603 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP fasudil inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein] CTD PMID:20869980 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mmp8 matrix metallopeptidase 8 affects expression ISO fasudil affects the expression of MMP8 mRNA CTD PMID:26120273 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects expression ISO fasudil affects the expression of MMP9 mRNA CTD PMID:26120273 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein] CTD PMID:30924981 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO fasudil results in decreased expression of MYH7 mRNA CTD PMID:22465603 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
fasudil inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]
CTD PMID:23376009, PMID:30924981 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of NOS2 protein] CTD PMID:30462329 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein] CTD PMID:16452496 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO fasudil results in decreased expression of NPPA mRNA CTD PMID:22465603 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO fasudil results in decreased expression of NPPB mRNA CTD PMID:22465603 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pkn2 protein kinase N2 decreases activity ISO fasudil results in decreased activity of PKN2 protein CTD PMID:10998351 NCBI chr 2:248,735,699...248,840,735
Ensembl chr 2:248,735,699...248,840,735
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP fasudil inhibits the reaction [Paraquat results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form] CTD PMID:22429817, PMID:30088170 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
fasudil inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of RELA protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
CTD PMID:23376009, PMID:30462329, PMID:30924981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rho rhodopsin multiple interactions ISO
EXP
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]
fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]; fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
CTD PMID:30088170, PMID:30924981 NCBI chr 4:147,832,136...147,837,298
Ensembl chr 4:147,832,136...147,837,298
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO fasudil results in decreased expression of RHOA mRNA; fasudil results in decreased expression of RHOA protein CTD PMID:26172442 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression
multiple interactions
ISO
EXP
fasudil results in decreased expression of ROCK1 mRNA; fasudil results in decreased expression of ROCK1 protein
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]
CTD PMID:20037814, PMID:22429817, PMID:23376009, PMID:26172442, PMID:30088170, PMID:30924981 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity
multiple interactions
EXP
ISO
fasudil results in decreased activity of ROCK2 protein
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein]
CTD PMID:10998351, PMID:30924981 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases activity ISO fasudil results in decreased activity of RPS6KA1 protein CTD PMID:10998351 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO fasudil results in decreased activity of RPS6KA5 protein CTD PMID:10998351 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO fasudil results in decreased activity of RPS6KB1 protein CTD PMID:10998351 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein CTD PMID:31935364 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO fasudil results in increased expression of SLC12A2 protein CTD PMID:21474433 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Syp synaptophysin multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:22062134 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
fasudil results in decreased expression of TGFB1 protein
fasudil inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
CTD PMID:22465603, PMID:23376009 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO fasudil affects the expression of TIMP1 mRNA CTD PMID:22465603 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO
EXP
fasudil inhibits the reaction [Paraquat results in decreased expression of TJP1 protein] CTD PMID:30088170 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions
ISO
EXP
fasudil affects the expression of TNF mRNA
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of TNF protein]
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD PMID:26120273, PMID:30088170, PMID:30462329, PMID:30924981 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:30831131 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression ISO fasudil affects the expression of VEGFA mRNA CTD PMID:26120273 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization
EXP
ISO
ML 7 results in decreased expression of ACTA2
ML 7 affects the localization of ACTA2 protein
CTD PMID:11591817, PMID:11868461 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO ML 7 results in decreased phosphorylation of BCAR1 protein CTD PMID:18718759 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ML 7 results in decreased expression of BIRC5 protein CTD PMID:18710790 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein] CTD PMID:16799973 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]
ML 7 results in decreased expression of CCND1 protein
CTD PMID:16799973, PMID:18710790 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] CTD PMID:16799973 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdh1 cadherin 1 decreases activity
affects localization
ISO ML 7 results in decreased activity of CDH1 protein
ML 7 affects the localization of CDH1 protein
CTD PMID:16030252 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein] CTD PMID:16799973 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO ML 7 results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ML 7 results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO ML 7 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:267,416,681...267,465,049
Ensembl chr 1:267,417,459...267,463,705
JBrowse link
G Csf2 colony stimulating factor 2 affects activity ISO ML 7 affects the activity of CSF2 protein CTD PMID:8471626 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases expression
ISO ML 7 affects the localization of CTNNB1 protein
ML 7 results in decreased expression of CTNNB1 protein
CTD PMID:18710790 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dst dystonin affects localization ISO ML 7 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Egf epidermal growth factor multiple interactions EXP ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]; ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G F2 coagulation factor II multiple interactions
affects activity
decreases activity
ISO
EXP
ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
ML 7 affects the activity of F2 protein
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein
CTD PMID:1643115, PMID:14557824, PMID:15284075, PMID:16675616 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein] CTD PMID:16799973 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Il17a interleukin 17A multiple interactions ISO ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:19374788 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
decreases activity
ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]
ML 7 results in decreased activity of ITGB1 protein
CTD PMID:14691950, PMID:16723733 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein] CTD PMID:16799973 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO ML 7 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK1 protein CTD PMID:18710790 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK3 protein CTD PMID:18710790 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
ML 7 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
ML 7 results in decreased activity of MPO protein
CTD PMID:15863634, PMID:19374788 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ML 7 results in decreased expression of MYC protein CTD PMID:18710790 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh2 myosin heavy chain 2 affects localization
decreases activity
ISO ML 7 affects the localization of MYH2 protein
ML 7 results in decreased activity of MYH2 protein
CTD PMID:16030252 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation
ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
ML 7 results in decreased phosphorylation of MYL7 protein
CTD PMID:15621049 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553
JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased expression of MYL9 protein modified form
CTD PMID:1643115, PMID:7503253, PMID:9618396, PMID:11751986, PMID:12745062, PMID:15284075, PMID:15347643, PMID:15863634, PMID:16799973, PMID:17138966, PMID:17272349, PMID:17914957, PMID:18710790, PMID:18835913, PMID:19525378, PMID:19940258, PMID:19943851 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Mylk myosin light chain kinase multiple interactions
decreases activity
ISO
EXP
[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK protein
CTD PMID:1643115, PMID:9618396, PMID:10198341, PMID:10733514, PMID:11054866, PMID:12534346, PMID:16675616, PMID:16723733, PMID:17541957, PMID:18773891, PMID:18835913, PMID:19374788, PMID:19943851 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO ML 7 results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
JBrowse link
G Myog myogenin decreases expression ISO ML 7 results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]; ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NCF1 protein] CTD PMID:7575484 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Prkcb protein kinase C, beta decreases expression EXP ML 7 results in decreased expression of PRKCB protein CTD PMID:17272349 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of PTK2 protein CTD PMID:18718759 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases activity
increases activity
EXP ML 7 results in decreased activity of RAC1 protein
ML 7 results in increased activity of RAC1 protein
CTD PMID:12105187, PMID:12745062 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Ren renin multiple interactions
increases secretion
EXP [[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]; ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein] CTD PMID:9618396 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO ML 7 results in decreased activity of RPS6KA5 protein CTD PMID:12534346 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression
decreases activity
EXP ML 7 inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
ML 7 results in decreased expression of SLC2A2 protein
ML 7 results in decreased activity of SLC2A2 protein
CTD PMID:17272349 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein] CTD PMID:20164382 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO ML 7 results in decreased activity of TRPC6 protein CTD PMID:17603544 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases activity ISO ML 7 results in increased activity of TRPC7 protein CTD PMID:17603544 NCBI chr17:8,134,267...8,280,360
Ensembl chr17:8,135,251...8,279,515
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                organonitrogen heterocyclic compound 17485
                  diazepane 95
                    (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-ylidenecyanamide 0
                    N-acyldiazepane + 95
                    Tsukushinamine A 0
                    diazepanone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteromonocyclic compound 16469
                                    diazepane 95
                                      (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-ylidenecyanamide 0
                                      N-acyldiazepane + 95
                                      Tsukushinamine A 0
                                      diazepanone + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.