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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phoxim
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Accession:CHEBI:38812 term browser browse the term
Definition:An organothiophosphate insecticide that has formula C12H15N2O3PS.
Synonyms:exact_synonym: O-{[cyano(phenyl)methylidene]amino} O,O-diethyl phosphorothioate
 related_synonym: Formula=C12H15N2O3PS;   InChI=1S/C12H15N2O3PS/c1-3-15-18(19,16-4-2)17-14-12(10-13)11-8-6-5-7-9-11/h5-9H,3-4H2,1-2H3/b14-12-;   InChIKey=ATROHALUCMTWTB-OWBHPGMISA-N;   O,O-Diethyl-alpha-cyanobenzylidineaminooxyphosphonothiate;   O-(alpha-cyanobenzylideneamino) O,O-diethyl thiophosphate;   O-{[cyano(phenyl)methylidene]amino} O,O-diethyl thiophosphate;   Phenylglyoxylnitrile oxime O,O-diethyl phosphorothioate;   SMILES=CCOP(=S)(OCC)O\\N=C(\\C#N)c1ccccc1;   alpha-(((Diethoxyphosphinothioyl)oxy)imino)benzeneacetonitrile
 xref: Beilstein:2995646;   CAS:14816-18-3;   KEGG:C18757;   KEGG:D08373
 xref_mesh: MESH:C003135


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phoxim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein CTD PMID:15793557 PMID:33497710 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions ISO phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 affects expression ISO phoxim affects the expression of ARL6IP5 protein CTD PMID:15799245 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of BCHE protein CTD PMID:33497710 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cldn4 claudin 4 decreases expression
multiple interactions
EXP phoxim results in decreased expression of CLDN4 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]
CTD PMID:30003487 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO phoxim binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions
EXP phoxim results in increased expression of GPX2 mRNA
Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]
CTD PMID:30003487 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phoxim results in decreased expression of IL1B mRNA CTD PMID:30003487 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP phoxim results in decreased expression of IL6 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]
CTD PMID:30003487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP phoxim results in increased expression of NFE2L2 mRNA CTD PMID:30003487 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phoxim binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA] CTD PMID:30003487 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO phoxim binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO phoxim binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein]
phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein
CTD PMID:30003487 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        agrochemical 14700
          phoxim 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      chalcogen 19393
                        oxygen atom 19356
                          oxygen molecular entity 19356
                            hydroxides 19083
                              oxoacid 18310
                                pnictogen oxoacid 10315
                                  phosphorus oxoacid 9240
                                    phosphoric acids 7960
                                      phosphoric acid 7960
                                        phosphoric acid derivative 7640
                                          phosphate 7640
                                            organic phosphate 7639
                                              organic thiophosphate 2893
                                                phoxim 16
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