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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydropterin
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Accession:CHEBI:38797 term browser browse the term
Synonyms:related_synonym: dihydropterins


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L-erythro-7,8-dihydrobiopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein increases abundance
multiple interactions
EXP APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin
GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]
CTD PMID:22886847 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G EPO erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin] CTD PMID:25041251 PMID:25490417 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G GCH1 GTP cyclohydrolase 1 increases abundance
multiple interactions
ISO GCH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]
CTD PMID:25490417 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP 7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides] CTD PMID:19011239 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24381
    chemical entity 24349
      atom 24338
        nonmetal atom 24042
          nitrogen atom 20866
            nitrogen molecular entity 20866
              organonitrogen compound 20534
                organonitrogen heterocyclic compound 19277
                  pteridines 10498
                    pterins 9547
                      dihydropterin 4
                        (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate 0
                        (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin 0
                        2-amino-4-oxo-6-(erythro-1,2,3-trihydroxypropyl)-7,8-dihydroxypteridine triphosphate 0
                        2-amino-6-(1-hydroxyethyl)-7-methyl-7,8-dihydropteridin-4-one 0
                        2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol 0
                        2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one + 0
                        2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one 0
                        6,7-dihydrobiopterin + 0
                        6-(1,2-dihydroxy-1-methyl-3-triphosphooxypropyl)-7-methyl-7,8-dihydropterin 0
                        6-pyruvoyl-7,8-dihydropterin 0
                        7,8-dihydro-D-neopterin 2',3'-cyclic phosphate 0
                        7,8-dihydrobiopterin + 4
                        7,8-dihydromonapterin 0
                        7,8-dihydromonapterin 3-triphosphate 0
                        7,8-dihydroneopterin + 0
                        7,8-dihydroneopterin 2'-phosphate 0
                        7,8-dihydroneopterin 3'-phosphate 0
                        7,8-dihydroneopterin 3'-triphosphate 0
                        7,8-dihydroxanthopterin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24381
    subatomic particle 24338
      composite particle 24338
        hadron 24338
          baryon 24338
            nucleon 24338
              atomic nucleus 24338
                atom 24338
                  main group element atom 24185
                    p-block element atom 24185
                      carbon group element atom 23965
                        carbon atom 23925
                          organic molecular entity 23925
                            organic molecule 23807
                              organic cyclic compound 23092
                                organic heterocyclic compound 21232
                                  organic heteropolycyclic compound 20275
                                    organic heterobicyclic compound 17852
                                      pteridines 10498
                                        pterins 9547
                                          dihydropterin 4
                                            (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate 0
                                            (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin 0
                                            2-amino-4-oxo-6-(erythro-1,2,3-trihydroxypropyl)-7,8-dihydroxypteridine triphosphate 0
                                            2-amino-6-(1-hydroxyethyl)-7-methyl-7,8-dihydropteridin-4-one 0
                                            2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol 0
                                            2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one + 0
                                            2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one 0
                                            6,7-dihydrobiopterin + 0
                                            6-(1,2-dihydroxy-1-methyl-3-triphosphooxypropyl)-7-methyl-7,8-dihydropterin 0
                                            6-pyruvoyl-7,8-dihydropterin 0
                                            7,8-dihydro-D-neopterin 2',3'-cyclic phosphate 0
                                            7,8-dihydrobiopterin + 4
                                            7,8-dihydromonapterin 0
                                            7,8-dihydromonapterin 3-triphosphate 0
                                            7,8-dihydroneopterin + 0
                                            7,8-dihydroneopterin 2'-phosphate 0
                                            7,8-dihydroneopterin 3'-phosphate 0
                                            7,8-dihydroneopterin 3'-triphosphate 0
                                            7,8-dihydroxanthopterin 0
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