CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: thiadiazinane
Accession: CHEBI:38781
browse the term
Synonyms: related_synonym: thiadiazinanes
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Aen
apoptosis enhancing nuclease
increases expression
ISO
buprofezin results in increased expression of AEN mRNA
CTD
PMID:36287832
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
buprofezin results in increased expression of AIFM1 mRNA
CTD
PMID:36287832
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Aifm3
apoptosis inducing factor, mitochondria associated 3
increases expression
ISO
buprofezin results in increased expression of AIFM3 mRNA
CTD
PMID:36287832
NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248
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Ambra1
autophagy and beclin 1 regulator 1
increases expression
ISO
buprofezin results in increased expression of AMBRA1 mRNA
CTD
PMID:36287832
NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
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Atg10
autophagy related 10
increases expression
ISO
buprofezin results in increased expression of ATG10 mRNA
CTD
PMID:36287832
NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
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Atg12
autophagy related 12
increases expression
ISO
buprofezin results in increased expression of ATG12 mRNA
CTD
PMID:36287832
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg5
autophagy related 5
increases expression
ISO
buprofezin results in increased expression of ATG5 mRNA
CTD
PMID:36287832
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atg7
autophagy related 7
increases expression
ISO
buprofezin results in increased expression of ATG7 mRNA
CTD
PMID:36287832
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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Atp2b4
ATPase plasma membrane Ca2+ transporting 4
decreases expression
ISO
buprofezin results in decreased expression of ATP2B4 mRNA
CTD
PMID:36287832
NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
buprofezin results in increased expression of BAX protein
CTD
PMID:36287832
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
buprofezin results in decreased expression of BCL2 mRNA; buprofezin results in decreased expression of BCL2 protein
CTD
PMID:36287832
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Becn1
beclin 1
increases expression
ISO
buprofezin results in increased expression of BECN1 protein
CTD
PMID:36287832
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bok
BCL2 family apoptosis regulator BOK
increases expression
ISO
buprofezin results in increased expression of BOK mRNA
CTD
PMID:36287832
NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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Caap1
caspase activity and apoptosis inhibitor 1
decreases expression
ISO
buprofezin results in decreased expression of CAAP1 mRNA
CTD
PMID:36287832
NCBI chr 5:109,313,253...109,414,323
Ensembl chr 5:109,361,912...109,414,314
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Casp3
caspase 3
increases activity
ISO
buprofezin results in increased activity of CASP3 protein
CTD
PMID:36287832
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
buprofezin results in increased activity of CASP9 protein
CTD
PMID:36287832
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity
ISO
buprofezin results in decreased activity of CAT protein
CTD
PMID:31199169
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyct
cytochrome c, testis
increases localization
ISO
buprofezin results in increased localization of CYCT protein
CTD
PMID:36287832
NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
G
Got1
glutamic-oxaloacetic transaminase 1
increases expression
ISO
buprofezin results in increased expression of GOT1 protein
CTD
PMID:31199169
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
increases expression
ISO
buprofezin results in increased expression of GPT protein
CTD
PMID:31199169
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
buprofezin results in increased lipidation of and results in increased localization of MAP1LC3B protein
CTD
PMID:36287832
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
buprofezin results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Rara
retinoic acid receptor, alpha
increases activity
ISO
buprofezin results in increased activity of RARA protein
CTD
PMID:20143881
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Sod1
superoxide dismutase 1
decreases activity
ISO
buprofezin results in decreased activity of SOD1 protein
CTD
PMID:31199169
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sqstm1
sequestosome 1
decreases expression
ISO
buprofezin results in decreased expression of SQSTM1 protein
CTD
PMID:36287832
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Triap1
TP53 regulated inhibitor of apoptosis 1
decreases expression
ISO
buprofezin results in decreased expression of TRIAP1 mRNA
CTD
PMID:36287832
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
G
Aen
apoptosis enhancing nuclease
increases expression
ISO
buprofezin results in increased expression of AEN mRNA
CTD
PMID:36287832
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
buprofezin results in increased expression of AIFM1 mRNA
CTD
PMID:36287832
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
G
Aifm3
apoptosis inducing factor, mitochondria associated 3
increases expression
ISO
buprofezin results in increased expression of AIFM3 mRNA
CTD
PMID:36287832
NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248
G
Ambra1
autophagy and beclin 1 regulator 1
increases expression
ISO
buprofezin results in increased expression of AMBRA1 mRNA
CTD
PMID:36287832
NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
G
Atg10
autophagy related 10
increases expression
ISO
buprofezin results in increased expression of ATG10 mRNA
CTD
PMID:36287832
NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
G
Atg12
autophagy related 12
increases expression
ISO
buprofezin results in increased expression of ATG12 mRNA
CTD
PMID:36287832
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
G
Atg5
autophagy related 5
increases expression
ISO
buprofezin results in increased expression of ATG5 mRNA
CTD
PMID:36287832
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
G
Atg7
autophagy related 7
increases expression
ISO
buprofezin results in increased expression of ATG7 mRNA
CTD
PMID:36287832
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
G
Atp2b4
ATPase plasma membrane Ca2+ transporting 4
decreases expression
ISO
buprofezin results in decreased expression of ATP2B4 mRNA
CTD
PMID:36287832
NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
buprofezin results in increased expression of BAX protein
CTD
PMID:36287832
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
buprofezin results in decreased expression of BCL2 mRNA; buprofezin results in decreased expression of BCL2 protein
CTD
PMID:36287832
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Becn1
beclin 1
increases expression
ISO
buprofezin results in increased expression of BECN1 protein
CTD
PMID:36287832
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Bok
BCL2 family apoptosis regulator BOK
increases expression
ISO
buprofezin results in increased expression of BOK mRNA
CTD
PMID:36287832
NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
G
Caap1
caspase activity and apoptosis inhibitor 1
decreases expression
ISO
buprofezin results in decreased expression of CAAP1 mRNA
CTD
PMID:36287832
NCBI chr 5:109,313,253...109,414,323
Ensembl chr 5:109,361,912...109,414,314
G
Casp3
caspase 3
increases activity
ISO
buprofezin results in increased activity of CASP3 protein
CTD
PMID:36287832
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
increases activity
ISO
buprofezin results in increased activity of CASP9 protein
CTD
PMID:36287832
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
decreases activity
ISO
buprofezin results in decreased activity of CAT protein
CTD
PMID:31199169
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Cyct
cytochrome c, testis
increases localization
ISO
buprofezin results in increased localization of CYCT protein
CTD
PMID:36287832
NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
G
Got1
glutamic-oxaloacetic transaminase 1
increases expression
ISO
buprofezin results in increased expression of GOT1 protein
CTD
PMID:31199169
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gpt
glutamic--pyruvic transaminase
increases expression
ISO
buprofezin results in increased expression of GPT protein
CTD
PMID:31199169
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
buprofezin results in increased lipidation of and results in increased localization of MAP1LC3B protein
CTD
PMID:36287832
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
buprofezin results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Rara
retinoic acid receptor, alpha
increases activity
ISO
buprofezin results in increased activity of RARA protein
CTD
PMID:20143881
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
G
Sod1
superoxide dismutase 1
decreases activity
ISO
buprofezin results in decreased activity of SOD1 protein
CTD
PMID:31199169
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sqstm1
sequestosome 1
decreases expression
ISO
buprofezin results in decreased expression of SQSTM1 protein
CTD
PMID:36287832
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Triap1
TP53 regulated inhibitor of apoptosis 1
decreases expression
ISO
buprofezin results in decreased expression of TRIAP1 mRNA
CTD
PMID:36287832
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
dazomet results in increased activity of NFE2L2 protein
CTD
PMID:20143881
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19811
chemical entity
19840
atom
19809
nonmetal atom
19747
nitrogen atom
18962
nitrogen molecular entity
18934
organonitrogen compound
18783
organonitrogen heterocyclic compound
18154
thiadiazinane
27
1,3,5-thiadiazinane
0
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one +
26
3-(2-furanylmethyl)-5-(2-methoxyethyl)-1,3,5-thiadiazinane-2-thione
0
5-tert-butyl-3-(phenylmethyl)-1,3,5-thiadiazinane-2-thione
0
Thiadiazin
0
dazomet
1
taurolidine
0
Path 2
CHEBI ontology
19811
subatomic particle
19809
composite particle
19809
hadron
19840
baryon
19809
nucleon
19809
atomic nucleus
19809
atom
19809
main group element atom
19759
p-block element atom
19759
carbon group element atom
19708
carbon atom
19734
organic molecular entity
19705
organic molecule
19658
organic cyclic compound
19471
organic heterocyclic compound
18862
organic heteromonocyclic compound
17772
thiadiazinane
27
1,3,5-thiadiazinane
0
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one +
26
3-(2-furanylmethyl)-5-(2-methoxyethyl)-1,3,5-thiadiazinane-2-thione
0
5-tert-butyl-3-(phenylmethyl)-1,3,5-thiadiazinane-2-thione
0
Thiadiazin
0
dazomet
1
taurolidine
0