CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxyquinoline
Accession: CHEBI:38774
browse the term
Synonyms: related_synonym: hydroxyquinolines
alt_id: CHEBI:26514; CHEBI:38772
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Ache
acetylcholinesterase
multiple interactions
ISO
Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein]
CTD
PMID:25856695
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ago2
argonaute RISC catalytic component 2
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein
CTD
PMID:22415087
NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
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Ak1
adenylate kinase 1
decreases expression
ISO
Clioquinol results in decreased expression of AK1 mRNA
CTD
PMID:19502547
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; [Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein
CTD
PMID:16648635
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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App
amyloid beta precursor protein
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]
CTD
PMID:16648635 PMID:18346929
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ar
androgen receptor
multiple interactions
ISO
[Clioquinol binds to Copper] which results in decreased expression of AR protein
CTD
PMID:17308104
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atf3
activating transcription factor 3
increases expression
ISO
Clioquinol results in increased expression of ATF3 mRNA
CTD
PMID:32661532
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
Clioquinol results in increased phosphorylation of ATM protein
CTD
PMID:22627294
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atox1
antioxidant 1 copper chaperone
increases oxidation
ISO
Clioquinol results in increased oxidation of ATOX1 protein
CTD
PMID:33034664
NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
decreases expression multiple interactions
ISO
Clioquinol results in decreased expression of ATP2A2 mRNA; Clioquinol results in decreased expression of ATP2A2 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 protein]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]
CTD
PMID:33511738
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Becn1
beclin 1
increases expression
ISO
Clioquinol results in increased expression of BECN1 protein
CTD
PMID:36396104
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bnip3l
BCL2 interacting protein 3 like
decreases expression
ISO
Clioquinol results in decreased expression of BNIP3L mRNA
CTD
PMID:19502547
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Calr
calreticulin
decreases expression
ISO
Clioquinol results in decreased expression of CALR mRNA; Clioquinol results in decreased expression of CALR protein
CTD
PMID:36396104
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Casp3
caspase 3
multiple interactions
ISO
Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]
CTD
PMID:17287498
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Clioquinol results in increased expression of CDKN1A mRNA
CTD
PMID:22627294
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Commd1
copper metabolism domain containing 1
affects response to substance
ISO
COMMD1 gene SNP affects the susceptibility to Clioquinol
CTD
PMID:25622337
NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
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Dbh
dopamine beta-hydroxylase
increases expression decreases secretion
ISO
Clioquinol results in increased expression of DBH mRNA Clioquinol results in decreased secretion of DBH protein
CTD
PMID:33034664
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Dcp1b
decapping mRNA 1B
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA
CTD
PMID:22415087
NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145
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Ddit3
DNA-damage inducible transcript 3
decreases expression
ISO
Clioquinol results in decreased expression of DDIT3 mRNA
CTD
PMID:36396104
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dicer1
dicer 1 ribonuclease III
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein
CTD
PMID:22415087
NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
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Drosha
drosha ribonuclease III
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein
CTD
PMID:22415087
NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]
CTD
PMID:18346929
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egln1
egl-9 family hypoxia-inducible factor 1
decreases expression
ISO
Clioquinol results in decreased expression of EGLN1 mRNA
CTD
PMID:19502547
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Egln2
egl-9 family hypoxia-inducible factor 2
decreases expression
ISO
Clioquinol results in decreased expression of EGLN2 mRNA
CTD
PMID:19502547
NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751
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Egr1
early growth response 1
increases expression
ISO
Clioquinol results in increased expression of EGR1 mRNA
CTD
PMID:19502547
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif4e
eukaryotic translation initiation factor 4E
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein
CTD
PMID:22415087
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Epo
erythropoietin
increases expression decreases expression
ISO
Clioquinol results in increased expression of EPO mRNA Clioquinol results in decreased expression of EPO mRNA
CTD
PMID:16973622 PMID:19502547
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Fn1
fibronectin 1
multiple interactions
ISO
[FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]
CTD
PMID:18346929
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Clioquinol promotes the reaction [FOS protein binds to CXCL8 promoter]
CTD
PMID:29966605
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
Clioquinol results in increased expression of GADD45A mRNA
CTD
PMID:22627294
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gata2
GATA binding protein 2
decreases expression multiple interactions
ISO
Clioquinol results in decreased expression of GATA2 protein GATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD
PMID:29966605
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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Gata3
GATA binding protein 3
decreases expression multiple interactions
ISO
Clioquinol results in decreased expression of GATA3 protein Clioquinol inhibits the reaction [GATA3 protein binds to CXCL8 promoter]; GATA3 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA3 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD
PMID:29966605
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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H2ax
H2A.X variant histone
increases phosphorylation
ISO
Clioquinol results in increased phosphorylation of H2AX protein
CTD
PMID:22627294
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions increases expression decreases hydroxylation decreases ubiquitination increases activity
ISO
[Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein] [Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein] Clioquinol results in decreased hydroxylation of HIF1A protein Clioquinol results in decreased ubiquitination of HIF1A protein Clioquinol results in increased activity of HIF1A protein
CTD
PMID:16973622 PMID:19502547 PMID:19679656
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hif1an
hypoxia inducible factor 1 subunit alpha inhibitor
multiple interactions decreases activity
ISO
Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein] Clioquinol results in decreased activity of HIF1AN protein
CTD
PMID:16973622
NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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Hif3a
hypoxia inducible factor 3 subunit alpha
decreases expression
ISO
Clioquinol results in decreased expression of HIF3A mRNA
CTD
PMID:19502547
NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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Hmox1
heme oxygenase 1
increases expression
ISO
Clioquinol results in increased expression of HMOX1 mRNA
CTD
PMID:32661532
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
Clioquinol results in decreased expression of HSPA5 mRNA
CTD
PMID:36396104
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Itga2
integrin subunit alpha 2
multiple interactions
ISO
ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]
CTD
PMID:18346929
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Itga5
integrin subunit alpha 5
multiple interactions
ISO
ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]
CTD
PMID:18346929
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Clioquinol promotes the reaction [JUN protein binds to CXCL8 promoter]
CTD
PMID:29966605
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Lox
lysyl oxidase
increases expression decreases secretion
ISO
Clioquinol results in increased expression of LOX mRNA Clioquinol results in decreased secretion of LOX protein
CTD
PMID:33034664
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
increases expression
ISO
Clioquinol results in increased expression of MAP1LC3A protein
CTD
PMID:36396104
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD
PMID:16648635 PMID:18346929
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:16648635 PMID:18346929
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein]
CTD
PMID:16648635
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mif
macrophage migration inhibitory factor
increases expression
ISO
Clioquinol results in increased expression of MIF mRNA
CTD
PMID:19502547
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
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Mir130a
microRNA 130a
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA
CTD
PMID:22415087
NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
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Mir223
microRNA 223
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA
CTD
PMID:22415087
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Mir29a
microRNA 29a
multiple interactions
ISO
[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA
CTD
PMID:22415087
NCBI chr 4:59,650,608...59,650,695
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP2 protein
CTD
PMID:16648635
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
multiple interactions
ISO
[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein
CTD
PMID:16648635
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein]
CTD
PMID:23360710
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mog
myelin oligodendrocyte glycoprotein
multiple interactions
ISO
Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein]
CTD
PMID:23360710
NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
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Ngf
nerve growth factor
multiple interactions
ISO
Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]
CTD
PMID:25758465
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ntrk1
neurotrophic receptor tyrosine kinase 1
multiple interactions
ISO
Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]
CTD
PMID:25758465
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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P4ha2
prolyl 4-hydroxylase subunit alpha 2
decreases expression
ISO
Clioquinol results in decreased expression of P4HA2 mRNA
CTD
PMID:19502547
NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314
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Pgk1
phosphoglycerate kinase 1
increases expression
ISO
Clioquinol results in increased expression of PGK1 mRNA
CTD
PMID:19502547
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Sqstm1
sequestosome 1
decreases expression
ISO
Clioquinol results in decreased expression of SQSTM1 protein
CTD
PMID:36396104
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
ISO
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein
CTD
PMID:18346929
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Tp53
tumor protein p53
multiple interactions increases phosphorylation
ISO
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Clioquinol results in increased phosphorylation of TP53 protein]
CTD
PMID:22627294
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Vegfa
vascular endothelial growth factor A
increases expression decreases expression multiple interactions
ISO
Clioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA protein Clioquinol results in decreased expression of VEGFA mRNA HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
CTD
PMID:16973622 PMID:19502547
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vopp1
VOPP1 WW domain binding protein
decreases expression
ISO
Clioquinol results in decreased expression of ECOP mRNA
CTD
PMID:19502547
NCBI chr 4:87,363,678...87,432,747
Ensembl chr 4:87,363,477...87,450,375
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Xbp1
X-box binding protein 1
multiple interactions
ISO
Clioquinol affects the splicing of and results in decreased expression of XBP1 mRNA alternative form
CTD
PMID:36396104
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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E2f1
E2F transcription factor 1
decreases expression multiple interactions
ISO
5-nitroso-8-quinolinol results in decreased expression of E2F1 protein Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of E2F1 protein]
CTD
PMID:16497787
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression multiple interactions
ISO
5-nitroso-8-quinolinol results in decreased expression of MYC protein Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of MYC protein]
CTD
PMID:16497787
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Rb1
RB transcriptional corepressor 1
multiple interactions decreases expression
ISO
Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of RB1 protein modified form]
CTD
PMID:16497787
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Casp1
caspase 1
multiple interactions
ISO
Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of CASP1 protein]
CTD
PMID:36002070
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Gsdmd
gasdermin D
multiple interactions
ISO
Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein]
CTD
PMID:36002070
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]
CTD
PMID:36002070
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Chlorquinaldol inhibits the reaction [NLRP3 protein binds to PYCARD protein]
CTD
PMID:36002070
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Pycard
PYD and CARD domain containing
multiple interactions
ISO
Chlorquinaldol inhibits the reaction [NLRP3 protein binds to PYCARD protein]
CTD
PMID:36002070
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Adrb2
adrenoceptor beta 2
increases activity
ISO
indacaterol results in increased activity of ADRB2 protein
CTD
PMID:34601065
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
G
Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Iodoquinol inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid]
CTD
PMID:30639138
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcc4
ATP binding cassette subfamily C member 4
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]
CTD
PMID:21483698
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
G
Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]
CTD
PMID:21483698
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Ahr
aryl hydrocarbon receptor
multiple interactions increases activity
ISO
AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein
CTD
PMID:20106948 PMID:27020609 PMID:28336214
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid
CTD
PMID:24709313
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression increases activity
ISO
[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA] Kynurenic Acid results in increased expression of CYP1A1 mRNA Kynurenic Acid results in increased activity of CYP1A1 protein
CTD
PMID:20106948
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Fgf1
fibroblast growth factor 1
decreases secretion
ISO
Kynurenic Acid results in decreased secretion of FGF1 protein
CTD
PMID:16392031
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
G
Gpr35
G protein-coupled receptor 35
multiple interactions
ISO
Kynurenic Acid binds to and results in increased activity of GPR35 protein
CTD
PMID:20826425
NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299
G
Il1b
interleukin 1 beta
multiple interactions
ISO
[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
CTD
PMID:20106948 PMID:35123988
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions increases expression
ISO
AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]
CTD
PMID:20106948
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ins2
insulin 2
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]
CTD
PMID:28951307
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Kmo
kynurenine 3-monooxygenase
multiple interactions
EXP
[Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid
CTD
PMID:30151725
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
G
Mpo
myeloperoxidase
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]
CTD
PMID:35123988
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]
CTD
PMID:35123988
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Ocln
occludin
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of OCLN protein]
CTD
PMID:35123988
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Kynurenic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein]
CTD
PMID:35123988
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Slc2a3
solute carrier family 2 member 3
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]
CTD
PMID:28951307
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
G
Tjp1
tight junction protein 1
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of TJP1 protein]
CTD
PMID:35123988
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
G
Tnf
tumor necrosis factor
multiple interactions
ISO
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
CTD
PMID:35123988
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
CTD
PMID:31638783
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cat
catalase
multiple interactions
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein]
CTD
PMID:31638783
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Foxo3
forkhead box O3
multiple interactions
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of and affects the localization of FOXO3 protein]; nitroxoline results in decreased expression of and affects the localization of FOXO3 protein
CTD
PMID:31638783
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Metap2
methionyl aminopeptidase 2
decreases activity
ISO
nitroxoline results in decreased activity of METAP2 protein
CTD
PMID:21088277
NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434
G
Sirt1
sirtuin 1
multiple interactions decreases expression
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] nitroxoline results in decreased expression of SIRT1 protein
CTD
PMID:31638783
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Sod1
superoxide dismutase 1
multiple interactions
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 protein]
CTD
PMID:31638783
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
multiple interactions
ISO
nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein]
CTD
PMID:31638783
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Pon1
paraoxonase 1
multiple interactions
ISO
2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate]; 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]
CTD
PMID:21382471
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Esr1
estrogen receptor 1
increases activity multiple interactions
ISO
4-hydroxyquinoline results in increased activity of ESR1 protein 4-hydroxyquinoline inhibits the reaction [Estradiol binds to ESR1 protein]
CTD
PMID:30896932
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr1
estrogen receptor 1
multiple interactions increases activity
ISO
6-hydroxyquinoline inhibits the reaction [Estradiol binds to ESR1 protein] 6-hydroxyquinoline results in increased activity of ESR1 protein
CTD
PMID:30896932
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Abcb5
ATP binding cassette subfamily B member 5
affects response to substance
ISO
ABCB5 gene SNP affects the susceptibility to Oxyquinoline
CTD
PMID:25622337
NCBI chr 6:139,836,528...139,932,830
Ensembl chr 6:139,835,949...139,932,830
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO
Oxyquinoline results in decreased expression of ABCG5 mRNA
CTD
PMID:21632981
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
G
Acad11
acyl-CoA dehydrogenase family, member 11
decreases expression
ISO
Oxyquinoline results in decreased expression of ACAD11 mRNA
CTD
PMID:21632981
NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
G
Acat2
acetyl-CoA acetyltransferase 2
decreases expression
ISO
Oxyquinoline results in decreased expression of ACAT2 mRNA
CTD
PMID:21632981
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
G
Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
ISO
Oxyquinoline results in decreased expression of ACSL3 mRNA
CTD
PMID:21632981
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
G
Acy1
aminoacylase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of ACY1 mRNA
CTD
PMID:21632981
NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
decreases expression
ISO
Oxyquinoline results in decreased expression of ADH4 mRNA
CTD
PMID:21632981
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adm
adrenomedullin
decreases expression
ISO
Oxyquinoline results in decreased expression of ADM mRNA
CTD
PMID:21632981
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
G
Adss1
adenylosuccinate synthase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of ADSS1 mRNA
CTD
PMID:21632981
NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998
G
Aga
aspartylglucosaminidase
decreases expression
ISO
Oxyquinoline results in decreased expression of AGA mRNA
CTD
PMID:21632981
NCBI chr16:38,504,661...38,516,607
Ensembl chr16:38,504,663...38,516,606
G
Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Oxyquinoline results in increased expression of AKR1B10 mRNA
CTD
PMID:21632981 PMID:26198647
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
Oxyquinoline results in increased expression of AKR1C1 mRNA
CTD
PMID:21632981
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
Oxyquinoline results in increased expression of AKR1C2 mRNA
CTD
PMID:21632981 PMID:26198647
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
G
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
increases expression
ISO
Oxyquinoline results in increased expression of ALDH1L1 mRNA
CTD
PMID:21632981
NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
G
Amdhd1
amidohydrolase domain containing 1
decreases expression
ISO
Oxyquinoline results in decreased expression of AMDHD1 mRNA
CTD
PMID:21632981
NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
G
Amot
angiomotin
increases expression
ISO
Oxyquinoline results in increased expression of AMOT mRNA
CTD
PMID:21632981
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
G
Angptl8
angiopoietin-like 8
decreases expression
ISO
Oxyquinoline results in decreased expression of ANGPTL8 mRNA
CTD
PMID:21632981
NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
G
Ankrd1
ankyrin repeat domain 1
increases expression
ISO
Oxyquinoline results in increased expression of ANKRD1 mRNA
CTD
PMID:21632981
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
G
Ankrd37
ankyrin repeat domain 37
decreases expression
ISO
Oxyquinoline results in decreased expression of ANKRD37 mRNA
CTD
PMID:21632981
NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
G
Apbb2
amyloid beta precursor protein binding family B member 2
decreases expression
ISO
Oxyquinoline results in decreased expression of APBB2 mRNA
CTD
PMID:21632981
NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495
G
Aqp3
aquaporin 3 (Gill blood group)
decreases expression
ISO
Oxyquinoline results in decreased expression of AQP3 mRNA
CTD
PMID:21632981
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
G
Arg1
arginase 1
increases expression
ISO
Oxyquinoline results in increased expression of ARG1 mRNA
CTD
PMID:21632981
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
G
Arg2
arginase 2
increases expression
ISO
Oxyquinoline results in increased expression of ARG2 mRNA
CTD
PMID:21632981
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
G
Arhgap44
Rho GTPase activating protein 44
decreases expression
ISO
Oxyquinoline results in decreased expression of ARHGAP44 mRNA
CTD
PMID:21632981
NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297
G
Arid3a
AT-rich interaction domain 3A
increases expression
ISO
Oxyquinoline results in increased expression of ARID3A mRNA
CTD
PMID:15612046
NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
G
Arrdc3
arrestin domain containing 3
decreases expression
ISO
Oxyquinoline results in decreased expression of ARRDC3 mRNA
CTD
PMID:21632981
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
G
Atp6v0a2
ATPase H+ transporting V0 subunit a2
decreases expression
ISO
Oxyquinoline results in decreased expression of ATP6V0A2 mRNA
CTD
PMID:21632981
NCBI chr12:31,947,220...31,979,875
Ensembl chr12:31,822,733...32,007,069
G
Azgp1
alpha-2-glycoprotein 1, zinc-binding
increases expression
ISO
Oxyquinoline results in increased expression of AZGP1 mRNA
CTD
PMID:21632981
NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
G
Bhlhe40
basic helix-loop-helix family, member e40
decreases expression
ISO
Oxyquinoline results in decreased expression of BHLHE40 mRNA
CTD
PMID:21632981
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
G
Bmp2k
BMP-2 inducible kinase
decreases expression
ISO
Oxyquinoline results in decreased expression of BMP2K mRNA
CTD
PMID:21632981
NCBI chr14:12,481,194...12,579,411
Ensembl chr14:12,484,729...12,579,134
G
Bpifb2
BPI fold containing family B, member 2
increases expression
ISO
Oxyquinoline results in increased expression of BPIFB2 mRNA
CTD
PMID:21632981
NCBI chr 3:142,356,990...142,377,053
Ensembl chr 3:142,358,051...142,377,044
G
Carnmt1
carnosine N-methyltransferase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of CARNMT1 mRNA
CTD
PMID:21632981
NCBI chr 1:216,093,720...216,123,360
Ensembl chr 1:216,093,695...216,121,006
G
Casp1
caspase 1
increases expression
ISO
Oxyquinoline results in increased expression of CASP1 mRNA
CTD
PMID:15612046
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Ccdc18
coiled-coil domain containing 18
decreases expression
ISO
Oxyquinoline results in decreased expression of CCDC18 mRNA
CTD
PMID:21632981
NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711
G
Ccn1
cellular communication network factor 1
increases expression
ISO
Oxyquinoline results in increased expression of CCN1 mRNA
CTD
PMID:21632981
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
G
Ccne2
cyclin E2
decreases expression
ISO
Oxyquinoline results in decreased expression of CCNE2 mRNA
CTD
PMID:21632981
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Cdc6
cell division cycle 6
decreases expression
ISO
Oxyquinoline results in decreased expression of CDC6 mRNA
CTD
PMID:21632981
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
G
Cdc7
cell division cycle 7
decreases expression
ISO
Oxyquinoline results in decreased expression of CDC7 mRNA
CTD
PMID:21632981
NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
G
Cdc73
cell division cycle 73
decreases expression
ISO
Oxyquinoline results in decreased expression of CDC73 mRNA
CTD
PMID:21632981
NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656
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Cdh1
cadherin 1
decreases expression
ISO
Oxyquinoline results in decreased expression of CDH1 mRNA
CTD
PMID:21632981
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Oxyquinoline results in increased expression of CDKN1A mRNA
CTD
PMID:21632981
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdo1
cysteine dioxygenase type 1
decreases expression
ISO
Oxyquinoline results in decreased expression of CDO1 mRNA
CTD
PMID:21632981
NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
G
Cenpk
centromere protein K
decreases expression
ISO
Oxyquinoline results in decreased expression of CENPK mRNA
CTD
PMID:21632981
NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706
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Cenps
centromere protein S
decreases expression
ISO
Oxyquinoline results in decreased expression of CENPS mRNA
CTD
PMID:21632981
NCBI chr 5:159,563,917...159,573,534
G
Chac2
ChaC glutathione specific gamma-glutamylcyclotransferase 2
decreases expression
ISO
Oxyquinoline results in decreased expression of CHAC2 mRNA
CTD
PMID:21632981
NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301
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Chst15
carbohydrate sulfotransferase 15
increases expression
ISO
Oxyquinoline results in increased expression of CHST15 mRNA
CTD
PMID:21632981
NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707
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Clgn
calmegin
decreases expression
ISO
Oxyquinoline results in decreased expression of CLGN mRNA
CTD
PMID:21632981
NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
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Clhc1
clathrin heavy chain linker domain containing 1
decreases expression
ISO
Oxyquinoline results in decreased expression of CLHC1 mRNA
CTD
PMID:21632981
NCBI chr14:103,288,116...103,328,725
Ensembl chr14:103,288,134...103,328,715
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Cmtr2
cap methyltransferase 2
decreases expression
ISO
Oxyquinoline results in decreased expression of CMTR2 mRNA
CTD
PMID:21632981
NCBI chr19:38,190,718...38,197,549
Ensembl chr19:38,190,642...38,197,804
G
Cpa6
carboxypeptidase A6
decreases expression
ISO
Oxyquinoline results in decreased expression of CPA6 mRNA
CTD
PMID:21632981
NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485
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Crebrf
CREB3 regulatory factor
increases expression
ISO
Oxyquinoline results in increased expression of CREBRF mRNA
CTD
PMID:21632981
NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
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Csad
cysteine sulfinic acid decarboxylase
decreases expression
ISO
Oxyquinoline results in decreased expression of CSAD mRNA
CTD
PMID:21632981
NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
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Csta
cystatin A
decreases expression
ISO
Oxyquinoline results in decreased expression of CSTA mRNA
CTD
PMID:21632981
NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
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Cygb
cytoglobin
increases expression
ISO
Oxyquinoline results in increased expression of CYGB mRNA
CTD
PMID:21632981
NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
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Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
decreases expression
ISO
Oxyquinoline results in decreased expression of CYP24A1 mRNA
CTD
PMID:21632981
NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
G
Cyp51
cytochrome P450, family 51
decreases expression
ISO
Oxyquinoline results in decreased expression of CYP51A1 mRNA
CTD
PMID:21632981
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Ddit4
DNA-damage-inducible transcript 4
decreases expression
ISO
Oxyquinoline results in decreased expression of DDIT4 mRNA
CTD
PMID:21632981
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Oxyquinoline results in increased expression of DEPP1 mRNA
CTD
PMID:21632981
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Dmxl1
Dmx-like 1
decreases expression
ISO
Oxyquinoline results in decreased expression of DMXL1 mRNA
CTD
PMID:21632981
NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456
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Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
decreases expression
ISO
Oxyquinoline results in decreased expression of DNAJB9 mRNA
CTD
PMID:21632981
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
G
Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
decreases expression
ISO
Oxyquinoline results in decreased expression of DNAJC3 mRNA
CTD
PMID:21632981
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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Dram1
DNA-damage regulated autophagy modulator 1
increases expression
ISO
Oxyquinoline results in increased expression of DRAM1 mRNA
CTD
PMID:21632981
NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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Dse
dermatan sulfate epimerase
increases expression
ISO
Oxyquinoline results in increased expression of DSE mRNA
CTD
PMID:21632981
NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
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E2f8
E2F transcription factor 8
decreases expression
ISO
Oxyquinoline results in decreased expression of E2F8 mRNA
CTD
PMID:21632981
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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Eed
embryonic ectoderm development
decreases expression
ISO
Oxyquinoline results in decreased expression of EED mRNA
CTD
PMID:21632981
NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
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Efcab7
EF-hand calcium binding domain 7
decreases expression
ISO
Oxyquinoline results in decreased expression of EFCAB7 mRNA
CTD
PMID:21632981
NCBI chr 5:114,525,403...114,576,130
Ensembl chr 5:114,525,167...114,576,129
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
[Copper binds to Oxyquinoline] which results in increased phosphorylation of EGFR protein
CTD
PMID:18346929
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
multiple interactions
ISO
[cupric acetate co-treated with Oxyquinoline] results in increased expression of EGR1 mRNA
CTD
PMID:10487485
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Emp3
epithelial membrane protein 3
increases expression
ISO
Oxyquinoline results in increased expression of EMP3 mRNA
CTD
PMID:21632981
NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988
G
Eogt
EGF domain specific O-linked N-acetylglucosamine transferase
decreases expression
ISO
Oxyquinoline results in decreased expression of EOGT mRNA
CTD
PMID:21632981
NCBI chr 4:129,718,897...129,756,558
Ensembl chr 4:129,718,901...129,756,445
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Eps8l3
EPS8 like 3
increases expression
ISO
Oxyquinoline results in increased expression of EPS8L3 mRNA
CTD
PMID:21632981
NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085
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Esm1
endothelial cell-specific molecule 1
decreases expression
ISO
Oxyquinoline results in decreased expression of ESM1 mRNA
CTD
PMID:21632981
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
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Etnppl
ethanolamine-phosphate phospho-lyase
decreases expression
ISO
Oxyquinoline results in decreased expression of ETNPPL mRNA
CTD
PMID:21632981
NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
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Etv4
ETS variant transcription factor 4
increases expression
ISO
Oxyquinoline results in increased expression of ETV4 mRNA
CTD
PMID:21632981
NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
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F3
coagulation factor III, tissue factor
increases expression
ISO
Oxyquinoline results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fabp5
fatty acid binding protein 5
decreases expression
ISO
Oxyquinoline results in decreased expression of FABP5 mRNA
CTD
PMID:15612046
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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Fam13a
family with sequence similarity 13, member A
decreases expression
ISO
Oxyquinoline results in decreased expression of FAM13A mRNA
CTD
PMID:21632981
NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860
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Fam13c
family with sequence similarity 13, member C
decreases expression
ISO
Oxyquinoline results in decreased expression of FAM13C mRNA
CTD
PMID:21632981
NCBI chr20:18,065,625...18,187,792
Ensembl chr20:18,065,628...18,187,592
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Fam241a
family with sequence similarity 241 member A
decreases expression
ISO
Oxyquinoline results in decreased expression of FAM241A mRNA
CTD
PMID:21632981
NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242
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Fdps
farnesyl diphosphate synthase
decreases expression
ISO
Oxyquinoline results in decreased expression of FDPS mRNA
CTD
PMID:21632981
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Ferry3
FERRY endosomal RAB5 effector complex subunit 3
decreases expression
ISO
Oxyquinoline results in decreased expression of FERRY3 mRNA
CTD
PMID:21632981
NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382
G
Filip1l
filamin A interacting protein 1-like
increases expression
ISO
Oxyquinoline results in increased expression of FILIP1L mRNA
CTD
PMID:21632981
NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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Fnip2
folliculin interacting protein 2
increases expression
ISO
Oxyquinoline results in increased expression of FNIP2 mRNA
CTD
PMID:21632981
NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
ISO
[cupric acetate co-treated with Oxyquinoline] results in increased expression of FOS mRNA Oxyquinoline results in decreased expression of FOS mRNA
CTD
PMID:10487485 PMID:21632981
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Frk
fyn-related Src family tyrosine kinase
decreases expression
ISO
Oxyquinoline results in decreased expression of FRK mRNA
CTD
PMID:21632981
NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114
G
Fry
FRY microtubule binding protein
increases expression
ISO
Oxyquinoline results in increased expression of FRY mRNA
CTD
PMID:21632981
NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116
G
Fxyd1
FXYD domain-containing ion transport regulator 1
increases expression
ISO
Oxyquinoline results in increased expression of FXYD1 mRNA
CTD
PMID:21632981
NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
increases expression
ISO
Oxyquinoline results in increased expression of G6PC1 mRNA
CTD
PMID:21632981
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
Gata6
GATA binding protein 6
decreases expression
ISO
Oxyquinoline results in decreased expression of GATA6 mRNA
CTD
PMID:21632981
NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
G
Gbp2
guanylate binding protein 2
increases expression
ISO
Oxyquinoline results in increased expression of GBP2 mRNA
CTD
PMID:21632981
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
G
Gckr
glucokinase regulator
increases expression
ISO
Oxyquinoline results in increased expression of GCKR mRNA
CTD
PMID:21632981
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
G
Gcnt2
glucosaminyl (N-acetyl) transferase 2
increases expression
ISO
Oxyquinoline results in increased expression of GCNT2 mRNA
CTD
PMID:15612046
NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
G
Gdap1
ganglioside-induced differentiation-associated-protein 1
decreases expression
ISO
Oxyquinoline results in decreased expression of GDAP1 mRNA
CTD
PMID:21632981
NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
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Gins4
GINS complex subunit 4
decreases expression
ISO
Oxyquinoline results in decreased expression of GINS4 mRNA
CTD
PMID:21632981
NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273
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Gpx8
glutathione peroxidase 8
decreases expression
ISO
Oxyquinoline results in decreased expression of GPX8 mRNA
CTD
PMID:21632981
NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195
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Grb7
growth factor receptor bound protein 7
increases expression
ISO
Oxyquinoline results in increased expression of GRB7 mRNA
CTD
PMID:21632981
NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
G
Guf1
GTP binding elongation factor GUF1
decreases expression
ISO
Oxyquinoline results in decreased expression of GUF1 mRNA
CTD
PMID:21632981
NCBI chr14:38,537,953...38,557,331
Ensembl chr14:38,537,953...38,557,331
G
H2bc8
H2B clustered histone 8
decreases expression
ISO
Oxyquinoline results in decreased expression of H2BC8 mRNA
CTD
PMID:21632981
NCBI chr17:42,708,658...42,709,408
G
Hal
histidine ammonia lyase
decreases expression
ISO
Oxyquinoline results in decreased expression of HAL mRNA
CTD
PMID:21632981
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
G
Hamp
hepcidin antimicrobial peptide
decreases expression
ISO
Oxyquinoline results in decreased expression of HAMP mRNA
CTD
PMID:21632981
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Haus3
HAUS augmin-like complex, subunit 3
decreases expression
ISO
Oxyquinoline results in decreased expression of HAUS3 mRNA
CTD
PMID:21632981
NCBI chr14:76,580,549...76,599,542
Ensembl chr14:76,580,546...76,752,463
G
Heatr3
HEAT repeat containing 3
decreases expression
ISO
Oxyquinoline results in decreased expression of HEATR3 mRNA
CTD
PMID:21632981
NCBI chr19:18,892,477...18,930,502
Ensembl chr19:18,893,144...18,930,509
G
Hectd2
HECT domain E3 ubiquitin protein ligase 2
decreases expression
ISO
Oxyquinoline results in decreased expression of HECTD2 mRNA
CTD
PMID:21632981
NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487
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Hey1
hes-related family bHLH transcription factor with YRPW motif 1
decreases expression
ISO
Oxyquinoline results in decreased expression of HEY1 mRNA
CTD
PMID:21632981
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
G
Hilpda
hypoxia inducible lipid droplet-associated
decreases expression
ISO
Oxyquinoline results in decreased expression of HILPDA mRNA
CTD
PMID:21632981
NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
G
Hira
histone cell cycle regulator
decreases expression
ISO
Oxyquinoline results in decreased expression of HIRA mRNA
CTD
PMID:21632981
NCBI chr11:82,024,469...82,133,212
Ensembl chr11:82,024,469...82,133,529
G
Hivep2
HIVEP zinc finger 2
increases expression
ISO
Oxyquinoline results in increased expression of HIVEP2 mRNA
CTD
PMID:21632981
NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
ISO
Oxyquinoline results in decreased expression of HMGCR mRNA
CTD
PMID:21632981
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmox1
heme oxygenase 1
multiple interactions decreases expression
EXP ISO
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 protein Oxyquinoline results in decreased expression of HMOX1 mRNA
CTD
PMID:15019574 PMID:21632981
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression affects localization
ISO
Oxyquinoline results in increased expression of HSPA1A protein Oxyquinoline affects the localization of HSPA1A protein
CTD
PMID:16239242
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa8
heat shock protein family A (Hsp70) member 8
affects localization
ISO
Oxyquinoline affects the localization of HSPA8 protein
CTD
PMID:16239242
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Id3
inhibitor of DNA binding 3
decreases expression
ISO
Oxyquinoline results in decreased expression of ID3 mRNA
CTD
PMID:21632981
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
G
Ift70b
intraflagellar transport 70B
decreases expression
ISO
Oxyquinoline results in decreased expression of IFT70B mRNA
CTD
PMID:21632981
NCBI chr 3:60,855,809...60,858,380
Ensembl chr 3:60,855,575...60,858,389
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Oxyquinoline results in increased expression of IGFBP1 mRNA
CTD
PMID:21632981
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
G
Igfbp3
insulin-like growth factor binding protein 3
decreases expression
ISO
Oxyquinoline results in decreased expression of IGFBP3 mRNA
CTD
PMID:21632981
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
G
Il15
interleukin 15
increases expression
ISO
Oxyquinoline results in increased expression of IL15 mRNA
CTD
PMID:15612046
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il6st
interleukin 6 cytokine family signal transducer
decreases expression
ISO
Oxyquinoline results in decreased expression of IL6ST mRNA
CTD
PMID:21632981
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
G
Inhbe
inhibin subunit beta E
decreases expression
ISO
Oxyquinoline results in decreased expression of INHBE mRNA
CTD
PMID:21632981
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Intu
inturned planar cell polarity protein
decreases expression
ISO
Oxyquinoline results in decreased expression of INTU mRNA
CTD
PMID:21632981
NCBI chr 2:123,600,972...123,685,331
Ensembl chr 2:123,609,807...123,682,676
G
Irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
decreases expression
ISO
Oxyquinoline results in decreased expression of IRAK1BP1 mRNA
CTD
PMID:21632981
NCBI chr 8:83,731,512...83,748,289
Ensembl chr 8:83,731,507...83,748,289
G
Isx
intestine-specific homeobox
increases expression
ISO
Oxyquinoline results in increased expression of ISX mRNA
CTD
PMID:21632981
NCBI chr19:13,217,637...13,239,754
Ensembl chr19:13,218,552...13,239,760
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[cupric acetate co-treated with Oxyquinoline] results in increased expression of JUN mRNA
CTD
PMID:10487485
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Katnal1
katanin catalytic subunit A1 like 1
affects response to substance
ISO
KATNAL1 gene SNP affects the susceptibility to Oxyquinoline
CTD
PMID:25622337
NCBI chr12:6,094,663...6,156,114
Ensembl chr12:6,102,836...6,157,553
G
Kbtbd8
kelch repeat and BTB domain containing 8
decreases expression
ISO
Oxyquinoline results in decreased expression of KBTBD8 mRNA
CTD
PMID:21632981
NCBI chr 4:127,675,967...127,688,785
Ensembl chr 4:127,676,141...127,687,697
G
Kctd18
potassium channel tetramerization domain containing 18
decreases expression
ISO
Oxyquinoline results in decreased expression of KCTD18 mRNA
CTD
PMID:21632981
NCBI chr 9:59,502,220...59,566,857
Ensembl chr 9:59,502,232...59,566,857
G
Kyat1
kynurenine aminotransferase 1
increases expression
ISO
Oxyquinoline results in increased expression of KYAT1 mRNA
CTD
PMID:21632981
NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
G
Laptm5
lysosomal protein transmembrane 5
increases expression
ISO
Oxyquinoline results in increased expression of LAPTM5 mRNA
CTD
PMID:15612046
NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
G
Leap2
liver enriched antimicrobial peptide 2
decreases expression
ISO
Oxyquinoline results in decreased expression of LEAP2 mRNA
CTD
PMID:21632981
NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
G
Lef1
lymphoid enhancer binding factor 1
decreases expression
ISO
Oxyquinoline results in decreased expression of LEF1 mRNA
CTD
PMID:15612046
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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Lgals3
galectin 3
decreases expression
ISO
Oxyquinoline results in decreased expression of LGALS3 mRNA
CTD
PMID:21632981
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
Oxyquinoline results in increased expression of LIF mRNA
CTD
PMID:26198647
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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Lipg
lipase G, endothelial type
decreases expression
ISO
Oxyquinoline results in decreased expression of LIPG mRNA
CTD
PMID:21632981
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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Lox
lysyl oxidase
decreases expression
ISO
Oxyquinoline results in decreased expression of LOX mRNA
CTD
PMID:21632981
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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Macf1
microtubule-actin crosslinking factor 1
decreases expression
ISO
Oxyquinoline results in decreased expression of MACF1 mRNA
CTD
PMID:21632981
NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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Manf
mesencephalic astrocyte-derived neurotrophic factor
decreases expression
ISO
Oxyquinoline results in decreased expression of MANF mRNA
CTD
PMID:21632981
NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438
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Mapk10
mitogen activated protein kinase 10
increases expression
ISO
Oxyquinoline results in increased expression of MAPK10 mRNA
CTD
PMID:15612046
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Mastl
microtubule associated serine/threonine kinase-like
decreases expression
ISO
Oxyquinoline results in decreased expression of MASTL mRNA
CTD
PMID:21632981
NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
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Mfsd8
major facilitator superfamily domain containing 8
decreases expression
ISO
Oxyquinoline results in decreased expression of MFSD8 mRNA
CTD
PMID:21632981
NCBI chr 2:123,822,042...123,847,808
Ensembl chr 2:123,816,614...123,857,971
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Miga1
mitoguardin 1
decreases expression
ISO
Oxyquinoline results in decreased expression of MIGA1 mRNA
CTD
PMID:21632981
NCBI chr 2:241,224,118...241,279,174
Ensembl chr 2:241,226,015...241,279,106
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Mixl1
Mix paired-like homeobox 1
decreases expression
ISO
Oxyquinoline results in decreased expression of MIXL1 mRNA
CTD
PMID:21632981
NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
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Msmo1
methylsterol monooxygenase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of MSMO1 mRNA
CTD
PMID:21632981
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Nap1l5
nucleosome assembly protein 1-like 5
decreases expression
ISO
Oxyquinoline results in decreased expression of NAP1L5 mRNA
CTD
PMID:21632981
NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654
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Ndrg1
N-myc downstream regulated 1
increases expression
ISO
Oxyquinoline results in increased expression of NDRG1 mRNA
CTD
PMID:21632981
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Neil3
nei-like DNA glycosylase 3
decreases expression
ISO
Oxyquinoline results in decreased expression of NEIL3 mRNA
CTD
PMID:21632981
NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
Oxyquinoline results in increased expression of NFE2L2 mRNA
CTD
PMID:26862668
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nkx6-2
NK6 homeobox 2
increases expression
ISO
Oxyquinoline results in increased expression of NKX6-2 mRNA
CTD
PMID:15612046
NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Oxyquinoline results in increased expression of NUPR1 mRNA
CTD
PMID:21632981
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Olfml3
olfactomedin-like 3
decreases expression
ISO
Oxyquinoline results in decreased expression of OLFML3 mRNA
CTD
PMID:21632981
NCBI chr 2:191,244,221...191,247,050
Ensembl chr 2:191,244,221...191,247,050
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Osgin1
oxidative stress induced growth inhibitor 1
increases expression
ISO
Oxyquinoline results in increased expression of OSGIN1 mRNA
CTD
PMID:21632981
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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Pabpc1l
poly(A) binding protein, cytoplasmic 1-like
decreases expression
ISO
Oxyquinoline results in decreased expression of PABPC1L mRNA
CTD
PMID:21632981
NCBI chr 3:152,692,825...152,725,997
Ensembl chr 3:152,693,700...152,725,997
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Pabpn1
poly(A) binding protein, nuclear 1
multiple interactions
ISO
Oxyquinoline inhibits the reaction [PABPN1 protein mutant form binds to PABPN1 protein mutant form]
CTD
PMID:16239242
NCBI chr15:28,368,100...28,372,712
Ensembl chr15:28,368,100...28,372,703
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Palld
palladin, cytoskeletal associated protein
increases expression
ISO
Oxyquinoline results in increased expression of PALLD mRNA
CTD
PMID:21632981
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Paqr3
progestin and adipoQ receptor family member 3
decreases expression
ISO
Oxyquinoline results in decreased expression of PAQR3 mRNA
CTD
PMID:21632981
NCBI chr14:12,462,568...12,484,999
Ensembl chr14:12,462,563...12,479,994
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Pck1
phosphoenolpyruvate carboxykinase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of PCK1 mRNA
CTD
PMID:21632981
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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PCOLCE2
procollagen C-endopeptidase enhancer 2
decreases expression
ISO
Oxyquinoline results in decreased expression of PCOLCE2 mRNA
CTD
PMID:21632981
NCBI chr 8:96,193,461...96,251,116
Ensembl chr 8:96,193,461...96,251,114
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Pdgfrl
platelet-derived growth factor receptor-like
decreases expression
ISO
Oxyquinoline results in decreased expression of PDGFRL mRNA
CTD
PMID:21632981
NCBI chr16:51,347,929...51,407,850
Ensembl chr16:51,347,948...51,407,850
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Pdk1
pyruvate dehydrogenase kinase 1
decreases expression
ISO
Oxyquinoline results in decreased expression of PDK1 mRNA
CTD
PMID:21632981
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Pdp2
pyruvate dehydrogenase phosphatase catalytic subunit 2
decreases expression
ISO
Oxyquinoline results in decreased expression of PDP2 mRNA
CTD
PMID:21632981
NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
decreases expression
ISO
Oxyquinoline results in decreased expression of PFKFB3 mRNA
CTD
PMID:21632981
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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Pgc
progastricsin
increases expression
ISO
Oxyquinoline results in increased expression of PGC mRNA
CTD
PMID:21632981
NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682
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Pigw
phosphatidylinositol glycan anchor biosynthesis, class W
decreases expression
ISO
Oxyquinoline results in decreased expression of PIGW mRNA
CTD
PMID:21632981
NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475
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Plac8
placenta associated 8
decreases expression
ISO
Oxyquinoline results in decreased expression of PLAC8 mRNA
CTD
PMID:21632981
NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
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Plin2
perilipin 2
decreases expression
ISO
Oxyquinoline results in decreased expression of PLIN2 mRNA
CTD
PMID:21632981
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Plk2
polo-like kinase 2
increases expression
ISO
Oxyquinoline results in increased expression of PLK2 mRNA
CTD
PMID:21632981
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
G
Plp1
proteolipid protein 1
decreases expression
ISO
Oxyquinoline results in decreased expression of PLP1 mRNA
CTD
PMID:21632981
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Plppr1
phospholipid phosphatase related 1
increases expression
ISO
Oxyquinoline results in increased expression of PLPPR1 mRNA
CTD
PMID:21632981
NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
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Ppp1r16a
protein phosphatase 1, regulatory subunit 16A
increases expression
ISO
Oxyquinoline results in increased expression of PPP1R16A mRNA
CTD
PMID:21632981
NCBI chr 7:108,391,664...108,414,812
Ensembl chr 7:108,391,656...108,419,509
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Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
decreases expression
ISO
Oxyquinoline results in decreased expression of PPP1R1C mRNA
CTD
PMID:15612046
NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
decreases expression
ISO
Oxyquinoline results in decreased expression of PPP1R3C mRNA
CTD
PMID:21632981
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
decreases expression
ISO
Oxyquinoline results in decreased expression of PPP3R1 mRNA
CTD
PMID:21632981
NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907
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Prorsd1
prolyl-tRNA synthetase associated domain containing 1
decreases expression
ISO
Oxyquinoline results in decreased expression of PRORSD1P mRNA
CTD
PMID:21632981
NCBI chr14:103,257,979...103,260,248
Ensembl chr14:103,257,979...103,260,248
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Ptcd2
pentatricopeptide repeat domain 2
decreases expression
ISO
Oxyquinoline results in decreased expression of PTCD2 mRNA
CTD
PMID:21632981
NCBI chr 2:30,712,276...30,739,968
Ensembl chr 2:30,712,280...30,739,942
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Ptchd4
patched domain containing 4
increases expression
ISO
Oxyquinoline results in increased expression of PTCHD4 mRNA
CTD
PMID:21632981
NCBI chr 9:18,462,934...18,666,272
Ensembl chr 9:18,463,737...18,665,705
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Ptms
parathymosin
increases expression
ISO
Oxyquinoline results in increased expression of PTMS mRNA
CTD
PMID:21632981
NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
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Qpct
glutaminyl-peptide cyclotransferase
decreases expression
ISO
Oxyquinoline results in decreased expression of QPCT mRNA
CTD
PMID:21632981
NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711
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Rabgap1l
RAB GTPase activating protein 1-like
decreases expression
ISO
Oxyquinoline results in decreased expression of RABGAP1L mRNA
CTD
PMID:21632981
NCBI chr13:72,464,114...73,059,845
Ensembl chr13:72,468,110...73,059,984
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Radx
RPA1 related single stranded DNA binding protein, X-linked
decreases expression
ISO
Oxyquinoline results in decreased expression of RADX mRNA
CTD
PMID:21632981
NCBI chr X:103,089,284...103,176,840
Ensembl chr X:103,089,284...103,176,838
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Rag1
recombination activating 1
decreases expression
ISO
Oxyquinoline results in decreased expression of RAG1 mRNA
CTD
PMID:15612046
NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
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Rbm24
RNA binding motif protein 24
increases expression
ISO
Oxyquinoline results in increased expression of RBM24 mRNA
CTD
PMID:21632981
NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
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Reep3
receptor accessory protein 3
decreases expression
ISO
Oxyquinoline results in decreased expression of REEP3 mRNA
CTD
PMID:21632981
NCBI chr20:21,493,868...21,578,698
Ensembl chr20:21,493,954...21,578,697
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Rgcc
regulator of cell cycle
increases expression
ISO
Oxyquinoline results in increased expression of RGCC mRNA
CTD
PMID:21632981
NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
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Rnft1
ring finger protein, transmembrane 1
decreases expression
ISO
Oxyquinoline results in decreased expression of RNFT1 mRNA
CTD
PMID:21632981
NCBI chr10:71,310,052...71,322,507
Ensembl chr10:71,310,104...71,323,778
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Rpgrip1l
Rpgrip1-like
decreases expression
ISO
Oxyquinoline results in decreased expression of RPGRIP1L mRNA
CTD
PMID:21632981
NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083
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Rsl1d1
ribosomal L1 domain containing 1
increases expression
ISO
Oxyquinoline results in increased expression of RSL1D1 mRNA
CTD
PMID:21632981
NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
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Sdf2l1
stromal cell-derived factor 2-like 1
decreases expression
ISO
Oxyquinoline results in decreased expression of SDF2L1 mRNA
CTD
PMID:21632981
NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
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Senp5
SUMO specific peptidase 5
decreases expression
ISO
Oxyquinoline results in decreased expression of SENP5 mRNA
CTD
PMID:21632981
NCBI chr11:68,784,699...68,819,569
Ensembl chr11:68,784,957...68,819,562
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Serpina7
serpin family A member 7
increases expression
ISO
Oxyquinoline results in increased expression of SERPINA7 mRNA
CTD
PMID:21632981
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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Serpine1
serpin family E member 1
decreases expression
ISO
Oxyquinoline results in decreased expression of SERPINE1 mRNA
CTD
PMID:21632981
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sgk2
serum/glucocorticoid regulated kinase 2
decreases expression
ISO
Oxyquinoline results in decreased expression of SGK2 mRNA
CTD
PMID:21632981
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
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Slc16a6
solute carrier family 16, member 6
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC16A6 mRNA
CTD
PMID:21632981
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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Slc22a3
solute carrier family 22 member 3
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC22A3 mRNA
CTD
PMID:21632981
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc30a1
solute carrier family 30 member 1
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC30A1 mRNA
CTD
PMID:21632981
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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Slc30a10
solute carrier family 30, member 10
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC30A10 mRNA
CTD
PMID:21632981
NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
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Slc35b3
solute carrier family 35 member B3
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC35B3 mRNA
CTD
PMID:21632981
NCBI chr17:25,846,590...25,873,115
Ensembl chr17:25,846,748...25,872,557
G
Slc35d1
solute carrier family 35 member D1
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC35D1 mRNA
CTD
PMID:21632981
NCBI chr 5:117,928,628...117,981,289
Ensembl chr 5:117,934,352...117,981,311
G
Slc51a
solute carrier family 51 member A
decreases expression
ISO
Oxyquinoline results in decreased expression of SLC51A mRNA
CTD
PMID:21632981
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slco4a1
solute carrier organic anion transporter family, member 4a1
increases expression
ISO
Oxyquinoline results in increased expression of SLCO4A1 mRNA
CTD
PMID:21632981
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
G
Slf1
SMC5-SMC6 complex localization factor 1
decreases expression
ISO
Oxyquinoline results in decreased expression of SLF1 mRNA
CTD
PMID:21632981
NCBI chr 2:6,767,015...6,874,428
Ensembl chr 2:6,767,015...6,867,149
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Smim13
small integral membrane protein 13
decreases expression
ISO
Oxyquinoline results in decreased expression of SMIM13 mRNA
CTD
PMID:21632981
NCBI chr17:23,497,662...23,515,705
G
Snu13
small nuclear ribonucleoprotein 13
decreases expression
ISO
Oxyquinoline results in decreased expression of SNU13 mRNA
CTD
PMID:15612046
NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872 Ensembl chr 1:113,565,295...113,570,872
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Sod2
superoxide dismutase 2
multiple interactions
EXP
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of SOD2 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 protein
CTD
PMID:15019574
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sorbs3
sorbin and SH3 domain containing 3
increases expression
ISO
Oxyquinoline results in increased expression of SORBS3 mRNA
CTD
PMID:21632981
NCBI chr15:45,252,921...45,284,758
Ensembl chr15:45,253,379...45,284,758
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Spa17
sperm autoantigenic protein 17
decreases expression
ISO
Oxyquinoline results in decreased expression of SPA17 mRNA
CTD
PMID:21632981
NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639
G
Spag4
sperm associated antigen 4
decreases expression
ISO
Oxyquinoline results in decreased expression of SPAG4 mRNA
CTD
PMID:21632981
NCBI chr 3:144,581,006...144,587,879
Ensembl chr 3:144,581,095...144,585,435
G
Spc25
SPC25 component of NDC80 kinetochore complex
decreases expression
ISO
Oxyquinoline results in decreased expression of SPC25 mRNA
CTD
PMID:21632981
NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
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Spin4
spindlin family, member 4
decreases expression
ISO
Oxyquinoline results in decreased expression of SPIN4 mRNA
CTD
PMID:21632981
NCBI chr X:59,888,728...59,892,817
Ensembl chr X:59,891,581...59,892,330
G
Spon2
spondin 2
increases expression
ISO
Oxyquinoline results in increased expression of SPON2 mRNA
CTD
PMID:21632981
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
G
Srd5a3
steroid 5 alpha-reductase 3
decreases expression
ISO
Oxyquinoline results in decreased expression of SRD5A3 mRNA
CTD
PMID:21632981
NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
G
Srxn1
sulfiredoxin 1
increases expression
ISO
Oxyquinoline results in increased expression of SRXN1 mRNA
CTD
PMID:21632981
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
G
Ssuh2
ssu-2 homolog
increases expression
ISO
Oxyquinoline results in increased expression of SSUH2 mRNA
CTD
PMID:21632981
NCBI chr 4:145,502,942...145,521,881
Ensembl chr 4:145,503,185...145,521,735
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Stil
STIL, centriolar assembly protein
decreases expression
ISO
Oxyquinoline results in decreased expression of STIL mRNA
CTD
PMID:21632981
NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
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Stom
stomatin
increases expression
ISO
Oxyquinoline results in increased expression of STOM mRNA
CTD
PMID:21632981
NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354
G
Sult2a1
sulfotransferase family 2A member 1
increases expression
ISO
Oxyquinoline results in increased expression of SULT2A1 mRNA
CTD
PMID:21632981
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
G
Tcfl5
transcription factor like 5
increases expression
ISO
Oxyquinoline results in increased expression of TCFL5 mRNA
CTD
PMID:15612046
NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
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Tex9
testis expressed 9
decreases expression
ISO
Oxyquinoline results in decreased expression of TEX9 mRNA
CTD
PMID:21632981
NCBI chr 8:73,168,519...73,213,935
Ensembl chr 8:73,177,810...73,214,261
G
Thap2
THAP domain containing 2
increases expression
ISO
Oxyquinoline results in increased expression of THAP2 mRNA
CTD
PMID:21632981
NCBI chr 7:50,992,912...51,007,582
Ensembl chr 7:50,995,793...51,008,061
G
Timm8a1
translocase of inner mitochondrial membrane 8A1
decreases expression
ISO
Oxyquinoline results in decreased expression of TIMM8A mRNA
CTD
PMID:21632981
NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960
G
Tm7sf2
transmembrane 7 superfamily member 2
decreases expression
ISO
Oxyquinoline results in decreased expression of TM7SF2 mRNA
CTD
PMID:21632981
NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
G
Tmcc1
transmembrane and coiled-coil domain family 1
increases expression
ISO
Oxyquinoline results in increased expression of TMCC1 mRNA
CTD
PMID:21632981
NCBI chr 4:149,069,252...149,239,585
Ensembl chr 4:149,069,260...149,239,620
G
Tmem116
transmembrane protein 116
decreases expression
ISO
Oxyquinoline results in decreased expression of TMEM116 mRNA
CTD
PMID:21632981
NCBI chr12:35,021,912...35,089,409
Ensembl chr12:35,041,572...35,089,430
G
Tmem128
transmembrane protein 128
decreases expression
ISO
Oxyquinoline results in decreased expression of TMEM128 mRNA
CTD
PMID:21632981
NCBI chr14:72,539,530...72,548,623
Ensembl chr14:72,539,532...72,548,550
G
Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Oxyquinoline results in increased expression of TNFAIP3 mRNA
CTD
PMID:21632981
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tnfsf10
TNF superfamily member 10
increases expression
ISO
Oxyquinoline results in increased expression of TNFSF10 mRNA
CTD
PMID:21632981
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
G
Tp63
tumor protein p63
increases expression
ISO
Oxyquinoline results in increased expression of TRP63 mRNA
CTD
PMID:15612046
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
G
Trpv2
transient receptor potential cation channel, subfamily V, member 2
increases expression
ISO
Oxyquinoline results in increased expression of TRPV2 mRNA
CTD
PMID:15612046
NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
G
Ttr
transthyretin
increases expression
ISO
Oxyquinoline results in increased expression of TTR mRNA
CTD
PMID:21632981
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
G
Ttyh3
tweety family member 3
increases expression
ISO
Oxyquinoline results in increased expression of TTYH3 mRNA
CTD
PMID:21632981
NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459
G
Tuba1a
tubulin, alpha 1A
decreases expression
ISO
Oxyquinoline results in decreased expression of TUBA1A mRNA
CTD
PMID:21632981
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
G
Tubb1
tubulin, beta 1 class VI
affects expression
ISO
Oxyquinoline affects the expression of TUBB1 mRNA
CTD
PMID:21632981
NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063
G
Tube1
tubulin, epsilon 1
decreases expression
ISO
Oxyquinoline results in decreased expression of TUBE1 mRNA
CTD
PMID:21632981
NCBI chr20:42,552,390...42,570,324
Ensembl chr20:42,552,437...42,570,314
G
Txnip
thioredoxin interacting protein
increases expression
ISO
Oxyquinoline results in increased expression of TXNIP mRNA
CTD
PMID:21632981
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Ubd
ubiquitin D
increases expression
ISO
Oxyquinoline results in increased expression of UBD mRNA
CTD
PMID:21632981
NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of Oxyquinoline
CTD
PMID:7574722
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
G
Usp43
ubiquitin specific peptidase 43
decreases expression
ISO
Oxyquinoline results in decreased expression of USP43 mRNA
CTD
PMID:21632981
NCBI chr10:52,549,200...52,611,168
Ensembl chr10:52,548,963...52,611,533
G
Utrn
utrophin
increases expression
ISO
Oxyquinoline results in increased expression of UTRN mRNA
CTD
PMID:21632981
NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
G
Ypel3
yippee-like 3
increases expression
ISO
Oxyquinoline results in increased expression of YPEL3 mRNA
CTD
PMID:21632981
NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
G
Zbtb38
zinc finger and BTB domain containing 38
increases expression
ISO
Oxyquinoline results in increased expression of ZBTB38 mRNA
CTD
PMID:21632981
NCBI chr 8:97,284,617...97,288,518
Ensembl chr 8:97,280,993...97,485,625
G
Zbtb8a
zinc finger and BTB domain containing 8a
decreases expression
ISO
Oxyquinoline results in decreased expression of ZBTB8A mRNA
CTD
PMID:21632981
NCBI chr 5:141,693,189...141,721,464
Ensembl chr 5:141,693,189...141,721,344
G
Zwint
ZW10 interacting kinetochore protein
decreases expression
ISO
Oxyquinoline results in decreased expression of ZWINT mRNA
CTD
PMID:21632981
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
xanthurenic acid binds to and results in increased activity of AHR protein
CTD
PMID:20106948
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of xanthurenic acid
CTD
PMID:24709313
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19932
chemical entity
19930
molecular entity
19930
polyatomic entity
19887
molecule
19779
organic molecule
19764
organic cyclic compound
19553
organic aromatic compound
19414
quinolines
2664
hydroxyquinoline
331
(8-hydroxy-5-quinolinyl)-oxidoammonium
0
1-(2,4-Dihydroxyquinolin-3-yl)ethan-1-one
0
1-cyclohexyl-5-\{4-[(4-hydroxy-2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium
0
1-hydroxy-2-nonylquinolin-4-one
0
2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid pentyl ester
0
2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid propyl ester
0
2-Methylquinolin-8-ol
0
2-fluoro-N-(8-hydroxy-5-quinolinyl)benzenesulfonamide
0
2-hydroxy-4-quinolone-3-carboxylic acid
0
2-n-octyl-4-hydroxyquinoline N-oxide
0
3,4,5,8-quinolinetetrol
0
3,4-Quinolinediol, 2-nonyl-
0
3-amino-7-hydroxy-3,4-dihydro-1H-quinolin-2-one
0
3-benzyl-1-butyl-4-hydroxy-1,2-dihydroquinolin-2-one
0
3-benzyl-4-hydroxyquinolin-2(1H)-one
0
3-ethyl-4-hydroxy-1-methyl-1,2-dihydroquinolin-2-one
0
3-n-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dione
0
4'-methoxyviridicatin(1-)
0
4,8-dimethyl-6-hydroxyquinoline
0
4-(2-hydroxyethylamino)-2-methyl-6-quinolinol
0
5,6-dihydroquinoline-2,5,6-triol
0
5,8-Dihydroxy-3,4-dihydrocarbostyril
0
5-(phenylmethoxymethyl)-7-(1-piperidinylmethyl)-8-quinolinol
0
5-(phenylmethoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol
0
5-[(2-bromoanilino)methyl]-8-quinolinol
0
5-[(2-chloroanilino)methyl]-8-quinolinol
0
5-[(2-fluoroanilino)methyl]-8-quinolinol
0
5-[(3-fluoroanilino)methyl]-8-quinolinol
0
5-[(3-pyridinylamino)methyl]-8-quinolinol
0
5-[[2-(trifluoromethyl)anilino]methyl]-8-quinolinol
0
5-[[2-fluoro-4-(trifluoromethyl)anilino]methyl]-8-quinolinol
0
5-[[2-furanylmethyl(methyl)amino]methyl]-8-quinolinol
0
5-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl]-8-quinolinol
0
5-hydroxy-3,4-dihydro-2(1h)-quinolinone
0
5-nitroso-8-quinolinol
3
6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one
0
7,8-dihydroxykynurenic acid
0
7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol
0
7-[(4-methyl-1-piperazinyl)methyl]-5-(phenylmethoxymethyl)-8-quinolinol
0
7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one
0
7-hydroxy-4-methyl-1H-quinolin-2-one
0
8-Hydroxy-4-methoxyquinoline-2-carbothioic S-acid
0
8-hydroxyquinoline-2-carbaldehyde
0
Indacaterol fumarate
0
N-(4-hydroxy-2-oxo-1H-quinolin-3-yl)heptanamide
0
N-(4-hydroxy-2-oxo-1H-quinolin-3-yl)pentanamide
0
N-[(5-bromo-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide
0
N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methoxyphenyl)methyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-cyclopropylmethyl]acetamide
0
N-[(5-fluoro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide
0
N-[2-furanyl-(8-hydroxy-7-quinolinyl)methyl]-2-methylpropanamide
0
N-methyl-4-hydroxy-2-quinolinone
0
Pycnarrhine
0
Quinolinediol
0
SF2809-I
0
SF2809-II
0
SF2809-V
0
UK 63052
0
UK 63598
0
UK 65662
0
Zanthobisquinolone
0
dihydroxyquinoline +
2
loretin
0
monohydroxyquinoline +
328
thalifolin
0
tiliquinol
0
uranidine
0
viridicatin
0
Path 2
CHEBI ontology
19932
subatomic particle
19930
composite particle
19930
hadron
19930
baryon
19930
nucleon
19930
atomic nucleus
19930
atom
19930
main group element atom
19876
p-block element atom
19876
carbon group element atom
19816
carbon atom
19812
organic molecular entity
19812
organic molecule
19764
organic cyclic compound
19553
organic heterocyclic compound
18905
organonitrogen heterocyclic compound
18179
quinolines
2664
hydroxyquinoline
331
(8-hydroxy-5-quinolinyl)-oxidoammonium
0
1-(2,4-Dihydroxyquinolin-3-yl)ethan-1-one
0
1-cyclohexyl-5-\{4-[(4-hydroxy-2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium
0
1-hydroxy-2-nonylquinolin-4-one
0
2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid pentyl ester
0
2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid propyl ester
0
2-Methylquinolin-8-ol
0
2-fluoro-N-(8-hydroxy-5-quinolinyl)benzenesulfonamide
0
2-hydroxy-4-quinolone-3-carboxylic acid
0
2-n-octyl-4-hydroxyquinoline N-oxide
0
3,4,5,8-quinolinetetrol
0
3,4-Quinolinediol, 2-nonyl-
0
3-amino-7-hydroxy-3,4-dihydro-1H-quinolin-2-one
0
3-benzyl-1-butyl-4-hydroxy-1,2-dihydroquinolin-2-one
0
3-benzyl-4-hydroxyquinolin-2(1H)-one
0
3-ethyl-4-hydroxy-1-methyl-1,2-dihydroquinolin-2-one
0
3-n-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dione
0
4'-methoxyviridicatin(1-)
0
4,8-dimethyl-6-hydroxyquinoline
0
4-(2-hydroxyethylamino)-2-methyl-6-quinolinol
0
5,6-dihydroquinoline-2,5,6-triol
0
5,8-Dihydroxy-3,4-dihydrocarbostyril
0
5-(phenylmethoxymethyl)-7-(1-piperidinylmethyl)-8-quinolinol
0
5-(phenylmethoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol
0
5-[(2-bromoanilino)methyl]-8-quinolinol
0
5-[(2-chloroanilino)methyl]-8-quinolinol
0
5-[(2-fluoroanilino)methyl]-8-quinolinol
0
5-[(3-fluoroanilino)methyl]-8-quinolinol
0
5-[(3-pyridinylamino)methyl]-8-quinolinol
0
5-[[2-(trifluoromethyl)anilino]methyl]-8-quinolinol
0
5-[[2-fluoro-4-(trifluoromethyl)anilino]methyl]-8-quinolinol
0
5-[[2-furanylmethyl(methyl)amino]methyl]-8-quinolinol
0
5-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl]-8-quinolinol
0
5-hydroxy-3,4-dihydro-2(1h)-quinolinone
0
5-nitroso-8-quinolinol
3
6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one
0
7,8-dihydroxykynurenic acid
0
7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol
0
7-[(4-methyl-1-piperazinyl)methyl]-5-(phenylmethoxymethyl)-8-quinolinol
0
7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one
0
7-hydroxy-4-methyl-1H-quinolin-2-one
0
8-Hydroxy-4-methoxyquinoline-2-carbothioic S-acid
0
8-hydroxyquinoline-2-carbaldehyde
0
Indacaterol fumarate
0
N-(4-hydroxy-2-oxo-1H-quinolin-3-yl)heptanamide
0
N-(4-hydroxy-2-oxo-1H-quinolin-3-yl)pentanamide
0
N-[(5-bromo-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide
0
N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methoxyphenyl)methyl]acetamide
0
N-[(5-chloro-8-hydroxy-7-quinolinyl)-cyclopropylmethyl]acetamide
0
N-[(5-fluoro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide
0
N-[2-furanyl-(8-hydroxy-7-quinolinyl)methyl]-2-methylpropanamide
0
N-methyl-4-hydroxy-2-quinolinone
0
Pycnarrhine
0
Quinolinediol
0
SF2809-I
0
SF2809-II
0
SF2809-V
0
UK 63052
0
UK 63598
0
UK 65662
0
Zanthobisquinolone
0
dihydroxyquinoline +
2
loretin
0
monohydroxyquinoline +
328
thalifolin
0
tiliquinol
0
uranidine
0
viridicatin
0