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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indazoles
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Accession:CHEBI:38769 term browser browse the term
Synonyms:xref_mesh: MESH:D007191


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indazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Indazoles analog binds to and results in increased activity of CNR1 protein; Indazoles analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]] CTD PMID:27429655 PMID:29963207 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Indazoles analog binds to and results in increased activity of CNR2 protein; Indazoles analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]] CTD PMID:27429655 PMID:29963207 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
3-BROMO-7-NITROINDAZOLE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 multiple interactions ISO [3-bromo-7-nitroindazole results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine CTD PMID:11006970 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PCNA protein] CTD PMID:23985028 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein] CTD PMID:23985028 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TRP53 protein] CTD PMID:23985028 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
7-NITROINDAZOLE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases activity EXP 7-nitroindazole results in increased activity of A2M CTD PMID:19240864 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Adnp activity-dependent neuroprotector homeobox decreases expression EXP 7-nitroindazole results in decreased expression of ADNP mRNA; 7-nitroindazole results in decreased expression of ADNP protein CTD PMID:18375135 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn3 endothelin 3 multiple interactions EXP 7-nitroindazole inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP 7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 7-nitroindazole inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat affects the localization of GAPDH protein] CTD PMID:20478973 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP 7-nitroindazole inhibits the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein CTD PMID:20826152 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity		 ISO
EXP		 7-nitroindazole inhibits the reaction [[Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein]; [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [7-nitroindazole results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine; [7-nitroindazole results in decreased activity of NOS1 protein] which results in decreased susceptibility to Methamphetamine
7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 7-nitroindazole inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]		 CTD PMID:8858965 PMID:9495865 PMID:9623721 PMID:11006970 PMID:15245872 More... NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein] CTD PMID:15617736 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP 7-nitroindazole affects the reaction [Sodium affects the expression of PTGS2 mRNA]; 7-nitroindazole inhibits the reaction [Sodium results in decreased expression of PTGS2 protein]
7-nitroindazole results in decreased expression of PTGS2 mRNA		 CTD PMID:10691779 PMID:10894794 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 multiple interactions EXP 7-nitroindazole inhibits the reaction [Paraquat affects the localization of SIAH1A protein] CTD PMID:20478973 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO 7-nitroindazole inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:20575850 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 7-nitroindazole affects the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:8931477 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat results in increased phosphorylation of TP53 protein] CTD PMID:20478973 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Adb-fubinaca term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions ISO ADB-FUBINACA binds to and results in increased activity of CNR1 protein CTD PMID:29963207 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO ADB-FUBINACA binds to and results in increased activity of CNR2 protein CTD PMID:29963207 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
axitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:27560553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO Axitinib results in decreased phosphorylation of MAPK3 protein
mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:27560553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein] CTD PMID:27044328 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein] CTD PMID:18202011 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Axitinib affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]; axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
benzydamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions
increases oxidation		 ISO Benzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]
FMO1 protein results in increased oxidation of Benzydamine		 CTD PMID:18809730 PMID:21435388 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation
multiple interactions		 ISO FMO2 protein results in increased oxidation of Benzydamine
[FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide		 CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases oxidation
affects metabolic processing
increases metabolic processing		 ISO Benzydamine inhibits the reaction [FMO3 protein results in increased chemical synthesis of clozapine N-oxide]
FMO3 protein results in increased oxidation of Benzydamine
FMO3 gene polymorphism affects the metabolism of Benzydamine
FMO3 protein results in increased metabolism of Benzydamine		 CTD PMID:17142560 PMID:18809730 PMID:21435388 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Benzydamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
gamendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding EXP Gamendazole binds to Eef1a1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP gamendazole binds to Hsp90ab1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
granisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Amy1 amylase alpha 1 multiple interactions EXP Granisetron inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Granisetron CTD PMID:30950278 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Granisetron CTD PMID:15286053 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]] CTD PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:30611738 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]] CTD PMID:30611738 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Granisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]] CTD PMID:30611738 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III increases expression ISO GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity ISO GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
lonidamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of AKT1 protein]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] CTD PMID:20605902 PMID:21889928 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions EXP lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions		 ISO lonidamine affects the localization of BAX protein
Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]		 CTD PMID:20605902 PMID:21889928 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]] CTD PMID:21889928 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO lonidamine results in decreased expression of BCL2L1 protein CTD PMID:21889928 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases activity
multiple interactions		 ISO lonidamine results in increased activity of BID protein
[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of BID protein		 CTD PMID:20605902 PMID:21889928 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein CTD PMID:20605902 PMID:21889928 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein; BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:21889928 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; lonidamine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20605902 PMID:21889928 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity
multiple interactions		 ISO
EXP		 lonidamine results in decreased activity of CFTR protein
lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]		 CTD PMID:12606488 PMID:15634668 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein CTD PMID:21889928 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK1 protein] CTD PMID:21889928 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK3 protein] CTD PMID:21889928 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO lonidamine results in decreased expression of MCL1 protein CTD PMID:21889928 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation		 ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein] CTD PMID:21889928 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation		 ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21889928 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO lonidamine results in increased phosphorylation of STK11 protein CTD PMID:23041229 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Testin testin gene multiple interactions
increases secretion
increases expression		 EXP adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; Dactinomycin inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; lonidamine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TESTIN mRNA]; lonidamine inhibits the reaction [Bucladesine results in decreased expression of TESTIN mRNA]
lonidamine results in increased expression of TESTIN; lonidamine results in increased expression of TESTIN mRNA		 CTD PMID:11090432 NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein] CTD PMID:20605902 PMID:21889928 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
niraparib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO niraparib binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 multiple interactions ISO niraparib binds to and results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
pazopanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO pazopanib results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO pazopanib results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA] CTD PMID:29356861 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Ar androgen receptor multiple interactions ISO pazopanib binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pazopanib results in increased expression of CYP2B6 mRNA CTD PMID:29356861 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO pazopanib results in increased expression of CYP2C8 mRNA CTD PMID:29356861
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO pazopanib results in increased expression of CYP3A4 mRNA CTD PMID:29356861 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO pazopanib results in increased secretion of IL1B protein CTD PMID:33271325 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO pazopanib results in decreased phosphorylation of MAPK1 protein
mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:27560553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein] CTD PMID:27560553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pazopanib inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pazopanib inhibits the reaction [T0901317 results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO pazopanib binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO pazopanib results in increased expression of PRTN3 protein CTD PMID:33271325 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO pazopanib binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO pazopanib binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
SCH772984 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO SCH772984 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:31706003 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adm adrenomedullin decreases secretion
multiple interactions		 EXP SCH772984 results in decreased secretion of ADM protein
SCH772984 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]		 CTD PMID:28087833 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP SCH772984 inhibits the reaction [APP protein modified form results in increased expression of GRK2 protein] CTD PMID:30399361 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog inhibits the reaction [BCL2 protein binds to BECN1 protein]] CTD PMID:35123989 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog inhibits the reaction [BCL2L1 protein binds to BECN1 protein]] CTD PMID:35123989 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog inhibits the reaction [BCL2 protein binds to BECN1 protein]]; SCH772984 inhibits the reaction [pachastrissamine analog inhibits the reaction [BCL2L1 protein binds to BECN1 protein]] CTD PMID:35123989 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased secretion of CCL2 protein] CTD PMID:28087833 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of and results in increased expression of CREB1 protein]; SCH772984 results in decreased phosphorylation of and results in decreased expression of CREB1 protein CTD PMID:28087833 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein] CTD PMID:28087833 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein] CTD PMID:31585129 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases secretion
multiple interactions		 EXP SCH772984 results in increased secretion of FGF2 protein
SCH772984 promotes the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]		 CTD PMID:28087833 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; SCH772984 inhibits the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]] CTD PMID:28087833 PMID:32319158 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpr4 G protein-coupled receptor 4 multiple interactions ISO SCH772984 inhibits the reaction [GPR4 protein affects the phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [GPR4 protein affects the phosphorylation of MAPK3 protein] CTD PMID:33161135 NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP SCH772984 inhibits the reaction [APP protein modified form results in increased expression of GRK2 protein] CTD PMID:30399361 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog results in increased expression of HMOX1 protein] CTD PMID:35123989 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased expression of HSPA1A protein] CTD PMID:28087833 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Il6 interleukin 6 multiple interactions EXP SCH772984 promotes the reaction [diphenylarsinic acid results in increased secretion of IL6 protein] CTD PMID:28087833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of JUN protein] CTD PMID:28087833 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog results in increased lipidation of MAP1LC3B protein] CTD PMID:35123989 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation EXP SCH772984 results in increased phosphorylation of MAP2K1 protein CTD PMID:28087833 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation EXP SCH772984 results in increased phosphorylation of MAP2K2 protein CTD PMID:28087833 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases activity
decreases expression		 EXP
ISO		 SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK1 protein]
SCH772984 results in decreased phosphorylation of MAPK1 protein
SCH772984 results in increased phosphorylation of MAPK1 protein
SCH772984 results in decreased activity of MAPK1 protein
SCH772984 results in decreased expression of MAPK1 protein
SCH772984 inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [GPR4 protein affects the phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [Ozone results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [pachastrissamine analog results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [saikosaponin D results in increased phosphorylation of and results in increased activity of MAPK1 protein]		 CTD PMID:28087833 PMID:29925859 PMID:32156566 PMID:32822868 PMID:33161135 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
decreases expression
increases phosphorylation
decreases activity		 EXP
ISO		 SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK3 protein]
SCH772984 results in decreased phosphorylation of MAPK3 protein
SCH772984 results in decreased expression of MAPK3 protein
SCH772984 inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of MAPK3 protein]; SCH772984 inhibits the reaction [GPR4 protein affects the phosphorylation of MAPK3 protein]; SCH772984 inhibits the reaction [Ozone results in increased phosphorylation of MAPK3 protein]; SCH772984 inhibits the reaction [pachastrissamine analog results in increased phosphorylation of MAPK3 protein]; SCH772984 inhibits the reaction [saikosaponin D results in increased phosphorylation of and results in increased activity of MAPK3 protein]
SCH772984 results in increased phosphorylation of MAPK3 protein
SCH772984 results in decreased activity of MAPK3 protein		 CTD PMID:28087833 PMID:29925859 PMID:32156566 PMID:32822868 PMID:33161135 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases expression		 EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK8 protein]
SCH772984 results in decreased expression of MAPK8 protein		 CTD PMID:28087833 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP SCH772984 inhibits the reaction [diphenylarsinic acid results in increased expression of NFE2L2 protein] CTD PMID:28087833 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog results in increased expression of NQO1 protein] CTD PMID:35123989 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO SCH772984 inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of RELA protein] CTD PMID:32156566 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA] CTD PMID:31585129 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Spi1 Spi-1 proto-oncogene multiple interactions ISO SCH772984 inhibits the reaction [saikosaponin D results in increased expression of SPI1 protein] CTD PMID:32822868 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO SCH772984 inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]]; SCH772984 inhibits the reaction [pachastrissamine analog results in increased expression of SQSTM1 protein] CTD PMID:35123989 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO SCH772984 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; SCH772984 inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:31706003 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Vim vimentin multiple interactions ISO SCH772984 inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:31706003 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    chemical entity 19749
      atom 19749
        nonmetal atom 19689
          nitrogen atom 18879
            nitrogen molecular entity 18879
              organonitrogen compound 18714
                organonitrogen heterocyclic compound 17997
                  indazoles 103
                    (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 0
                    (5-\{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl\}-2H-1,2,3-triazol-4-yl)methanol 0
                    1-Methyl-N-\{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl\}-1H-indazole-3-carboxamide 0
                    1-[(3,4-dichlorophenyl)methyl]-3-indazolecarboxylic acid 0
                    1-[(4-chlorophenyl)methyl]-3-indazolecarboxylic acid 0
                    1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                    1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-4-indazolecarboxamide 0
                    1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3-indazolecarboxamide 0
                    1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide 0
                    1-methyl-N-[(1S,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide 0
                    1H-indazol-3-amine 0
                    1H-indazol-6-amine 0
                    1H-indazole-3-carboxylic acid [2-(4-nitroanilino)-2-oxoethyl] ester 0
                    1H-indazole-3-carboxylic acid methyl ester 0
                    2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide + 2
                    2-ethyl-3-methoxy-N-(2-thiophen-2-ylethyl)-6-indazolecarboxamide 0
                    3-(1H-indazol-6-yl)-1-propan-2-yl-4-pyrazolo[3,4-d]pyrimidinamine 0
                    3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)-1H-indazole-6-carbonitrile 0
                    3-BROMO-7-NITROINDAZOLE 4
                    3-chloro-N-propan-2-yl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                    3-ethoxy-N-[(4-methoxyphenyl)methyl]-2-propyl-6-indazolecarboxamide 0
                    3-hex-1-ynyl-5H-indazolo[2,3-a][3,1]benzoxazine 0
                    4-chloro-1H-indazol-3-amine 0
                    7-NITROINDAZOLE 15
                    7-hydroxygranisetron 0
                    9'-desmethylgranisetron 0
                    AKB48 0
                    AKB48 N-(4-fluorobenzyl) analog 0
                    AKB48 N-(4-hydroxypentyl) metabolite 0
                    AKB48 N-(5-Fluoropentyl) analog 0
                    Adb-fubinaca 2
                    Adb-pinaca pentanoic acid metabolite 0
                    Benzydamine hydrochloride 0
                    Ethychlozate 0
                    GSK343 2
                    Granisetron hydrochloride 0
                    MK-8353 0
                    MLI-2 0
                    N-(1-adamantylmethyl)-2-ethyl-3-methoxy-6-indazolecarboxamide 0
                    N-(1H-indazol-6-yl)-2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)thio]acetamide 0
                    N-(2-hydroxyethyl)-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                    N-(2-methoxyethyl)-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                    N-(2-oxolanylmethyl)-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                    N-(4-methoxy-1-methyl-1H-indazol-3-yl)-2,5-dimethyl-3-furamide 0
                    N-[(2-methoxyphenyl)methyl]-2-methyl-3-prop-2-enoxy-6-indazolecarboxamide 0
                    N-[(2S)-1-hydroxypropan-2-yl]-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    N-cyclopropyl-3-[3-[[cyclopropyl(oxo)methyl]amino]-1H-indazol-6-yl]benzamide 0
                    SCH772984 33
                    [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone 0
                    [5-[1-(phenylmethyl)-3-indazolyl]-2-furanyl]methanol 0
                    axitinib 8
                    bendazac 0
                    benzydamine 4
                    gamendazole 2
                    granisetron 10
                    indazole + 0
                    indisetron 0
                    lificiguat 0
                    linifanib 0
                    lonidamine + 21
                    pazopanib 18
                    pictrelisib 0
                    salumycin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      p-block molecular entity 19698
                        carbon group molecular entity 19644
                          organic molecular entity 19640
                            organic molecule 19602
                              organic cyclic compound 19412
                                organic heterocyclic compound 18771
                                  organic heteropolycyclic compound 18259
                                    organic heterobicyclic compound 17228
                                      indazoles 103
                                        (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 0
                                        (5-\{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl\}-2H-1,2,3-triazol-4-yl)methanol 0
                                        1-Methyl-N-\{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl\}-1H-indazole-3-carboxamide 0
                                        1-[(3,4-dichlorophenyl)methyl]-3-indazolecarboxylic acid 0
                                        1-[(4-chlorophenyl)methyl]-3-indazolecarboxylic acid 0
                                        1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                                        1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-4-indazolecarboxamide 0
                                        1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3-indazolecarboxamide 0
                                        1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide 0
                                        1-methyl-N-[(1S,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide 0
                                        1H-indazol-3-amine 0
                                        1H-indazol-6-amine 0
                                        1H-indazole-3-carboxylic acid [2-(4-nitroanilino)-2-oxoethyl] ester 0
                                        1H-indazole-3-carboxylic acid methyl ester 0
                                        2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide + 2
                                        2-ethyl-3-methoxy-N-(2-thiophen-2-ylethyl)-6-indazolecarboxamide 0
                                        3-(1H-indazol-6-yl)-1-propan-2-yl-4-pyrazolo[3,4-d]pyrimidinamine 0
                                        3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)-1H-indazole-6-carbonitrile 0
                                        3-BROMO-7-NITROINDAZOLE 4
                                        3-chloro-N-propan-2-yl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                                        3-ethoxy-N-[(4-methoxyphenyl)methyl]-2-propyl-6-indazolecarboxamide 0
                                        3-hex-1-ynyl-5H-indazolo[2,3-a][3,1]benzoxazine 0
                                        4-chloro-1H-indazol-3-amine 0
                                        7-NITROINDAZOLE 15
                                        7-hydroxygranisetron 0
                                        9'-desmethylgranisetron 0
                                        AKB48 0
                                        AKB48 N-(4-fluorobenzyl) analog 0
                                        AKB48 N-(4-hydroxypentyl) metabolite 0
                                        AKB48 N-(5-Fluoropentyl) analog 0
                                        Adb-fubinaca 2
                                        Adb-pinaca pentanoic acid metabolite 0
                                        Benzydamine hydrochloride 0
                                        Ethychlozate 0
                                        GSK343 2
                                        Granisetron hydrochloride 0
                                        MK-8353 0
                                        MLI-2 0
                                        N-(1-adamantylmethyl)-2-ethyl-3-methoxy-6-indazolecarboxamide 0
                                        N-(1H-indazol-6-yl)-2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)thio]acetamide 0
                                        N-(2-hydroxyethyl)-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                                        N-(2-methoxyethyl)-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                                        N-(2-oxolanylmethyl)-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                                        N-(4-methoxy-1-methyl-1H-indazol-3-yl)-2,5-dimethyl-3-furamide 0
                                        N-[(2-methoxyphenyl)methyl]-2-methyl-3-prop-2-enoxy-6-indazolecarboxamide 0
                                        N-[(2S)-1-hydroxypropan-2-yl]-3-methyl-5H-indazolo[2,3-a][3,1]benzoxazine-9-carboxamide 0
                                        N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                                        N-cyclopropyl-3-[3-[[cyclopropyl(oxo)methyl]amino]-1H-indazol-6-yl]benzamide 0
                                        SCH772984 33
                                        [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone 0
                                        [5-[1-(phenylmethyl)-3-indazolyl]-2-furanyl]methanol 0
                                        axitinib 8
                                        bendazac 0
                                        benzydamine 4
                                        gamendazole 2
                                        granisetron 10
                                        indazole + 0
                                        indisetron 0
                                        lificiguat 0
                                        linifanib 0
                                        lonidamine + 21
                                        pazopanib 18
                                        pictrelisib 0
                                        salumycin 0
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