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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phorate
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Accession:CHEBI:38764 term browser browse the term
Definition:An organothiophosphate insecticide that has formula C7H17O2PS3.
Synonyms:exact_synonym: O,O-diethyl S-[(ethylsulfanyl)methyl] phosphorodithioate
 related_synonym: Formula=C7H17O2PS3;   InChI=1S/C7H17O2PS3/c1-4-8-10(11,9-5-2)13-7-12-6-3/h4-7H2,1-3H3;   InChIKey=BULVZWIRKLYCBC-UHFFFAOYSA-N;   O,O-Diethyl S-(ethylthio)methyl phosphorodithioate;   O,O-Diethyl S-ethylmercaptomethyl dithiophosphate;   O,O-diethyl S-[(ethylsulfanyl)methyl] dithiophosphate;   Phosphorodithioic acid, O,O-diethyl S-((ethylthio)methyl) ester;   SMILES=CCOP(=S)(OCC)SCSCC;   Thimet
 xref: Beilstein:1708517;   CAS:298-02-2;   KEGG:C18690
 xref_mesh: MESH:D010702
 xref: PPDB:519


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phorate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
Phorate metabolite results in decreased activity of ACHE protein; Phorate results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33720374 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin decreases expression EXP Phorate results in decreased expression of ALB protein CTD PMID:23280859 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP Phorate results in decreased expression of BCHE protein CTD PMID:23280859 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 increases expression EXP Phorate results in increased expression of CASP3 mRNA; Phorate results in increased expression of CASP3 protein CTD PMID:22197610 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression EXP Phorate results in increased expression of CASP9 mRNA; Phorate results in increased expression of CASP9 protein CTD PMID:22197610 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
Phorate results in decreased activity of CAT protein
CTD PMID:22034174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Phorate results in increased expression of GPT protein CTD PMID:23280859 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Phorate results in increased expression of TP53 mRNA; Phorate results in increased expression of TP53 protein CTD PMID:22197610 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        agrochemical 14856
          phorate 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      chalcogen 19413
                        oxygen atom 19378
                          oxygen molecular entity 19378
                            hydroxides 19103
                              oxoacid 18350
                                pnictogen oxoacid 10655
                                  phosphorus oxoacid 9634
                                    phosphoric acids 8429
                                      phosphoric acid 8429
                                        phosphoric acid derivative 8131
                                          phosphate 8131
                                            organic phosphate 8130
                                              organic thiophosphate 3645
                                                phorate 8
paths to the root