|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
affects activity
|
ISO
|
afromosin affects the activity of ABCC1 protein
|
CTD |
PMID:15796199 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; biochanin A promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]
|
CTD |
PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
decreases activity
|
ISO
|
biochanin A results in decreased activity of ABCC1 protein
|
CTD |
PMID:15581599 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
|
CTD |
PMID:15955639 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
ISO
|
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased activity of ACHE protein; [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]
|
CTD |
PMID:33410021 PMID:35547012 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Agrn
|
agrin
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of AGRN mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:172,031,528...172,064,539
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
multiple interactions increases activity affects binding
|
ISO EXP
|
AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter] biochanin A results in increased activity of AHR protein biochanin A binds to AHR protein
|
CTD |
PMID:16903077 PMID:28985473 PMID:31621310 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
Aldh7a1
|
aldehyde dehydrogenase 7 family, member A1
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of ALDH7A1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467
|
|
G
|
Arid5b
|
AT-rich interaction domain 5B
|
increases expression
|
ISO
|
biochanin A results in increased expression of ARID5B mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686
|
|
G
|
Babam2
|
BRISC and BRCA1 A complex member 2
|
increases expression
|
ISO
|
biochanin A results in increased expression of BABAM2 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:30,071,611...30,467,341
|
|
G
|
Bche
|
butyrylcholinesterase
|
multiple interactions
|
ISO
|
[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]
|
CTD |
PMID:35547012 |
|
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of BCL2 protein
|
CTD |
PMID:12791511 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of BCL2L1 protein
|
CTD |
PMID:12791511 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
|
|
G
|
Casp3
|
caspase 3
|
increases activity multiple interactions
|
ISO
|
biochanin A results in increased activity of CASP3 protein biochanin A inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]
|
CTD |
PMID:12791511 PMID:38648921 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein]
|
CTD |
PMID:33410021 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Cdh2
|
cadherin 2
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of CDH2 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of CDKN1A protein
|
CTD |
PMID:12111696 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Ckb
|
creatine kinase B
|
increases activity
|
ISO
|
biochanin A results in increased activity of CKB protein
|
CTD |
PMID:16621514 |
|
NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478
|
|
G
|
Cldn1
|
claudin 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529
|
|
G
|
Cyp19a1
|
cytochrome P450, family 19, subfamily a, polypeptide 1
|
multiple interactions decreases expression decreases activity
|
ISO
|
[Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein biochanin A results in decreased expression of CYP19A1 mRNA biochanin A results in decreased activity of CYP19A1 protein
|
CTD |
PMID:9435150 PMID:16965912 |
|
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions increases hydroxylation decreases methylation increases expression increases activity
|
ISO
|
AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA] CYP1A1 protein results in increased hydroxylation of biochanin A CYP1A1 protein results in decreased methylation of biochanin A biochanin A results in increased activity of CYP1A1 protein
|
CTD |
PMID:15479032 PMID:16903077 PMID:28985473 PMID:31621310 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
increases metabolic processing decreases activity
|
ISO EXP
|
CYP1A2 protein results in increased metabolism of biochanin A biochanin A results in decreased activity of CYP1A2 protein
|
CTD |
PMID:12814970 PMID:26278343 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
decreases methylation multiple interactions increases expression
|
ISO
|
CYP1B1 protein results in decreased methylation of biochanin A Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA] AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
|
CTD |
PMID:15479032 PMID:28985473 PMID:31621310 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
G
|
Cyp27b1
|
cytochrome P450, family 27, subfamily b, polypeptide 1
|
affects activity increases activity increases expression affects expression
|
ISO
|
biochanin A affects the activity of CYP27B1 protein biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA
|
CTD |
PMID:15795327 PMID:17659868 |
|
NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570
|
|
G
|
Dera
|
deoxyribose-phosphate aldolase
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of DERA mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 4:172,394,971...172,473,746
Ensembl chr 4:172,394,962...172,490,142
|
|
G
|
Eif5
|
eukaryotic translation initiation factor 5
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of EIF5 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821
|
|
G
|
Enpp5
|
ectonucleotide pyrophosphatase/phosphodiesterase family member 5
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of ENPP5 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 9:24,407,574...24,415,029
Ensembl chr 9:24,408,218...24,414,867
|
|
G
|
Eps15
|
epidermal growth factor receptor pathway substrate 15
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of EPS15 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions decreases expression affects binding
|
ISO EXP
|
biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein] biochanin A results in decreased expression of ESR1 protein [Fulvestrant co-treated with biochanin A] results in decreased expression of ESR1 protein; [Fulvestrant co-treated with biochanin A] results in increased expression of ESR1 mRNA biochanin A binds to ESR1 protein
|
CTD |
PMID:9751507 PMID:12598185 PMID:14579009 PMID:16076101 PMID:19913605 PMID:33049310 PMID:34848279 More...
|
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions increases expression decreases expression affects binding
|
ISO EXP
|
biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein] [Fulvestrant co-treated with biochanin A] results in increased expression of ESR2 mRNA; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of ESR2 protein] biochanin A results in increased expression of ESR2 mRNA biochanin A binds to ESR2 protein
|
CTD |
PMID:9751507 PMID:12224631 PMID:16076101 PMID:16566672 PMID:19913605 PMID:33049310 PMID:34848279 More...
|
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
|
|
G
|
Esrra
|
estrogen related receptor, alpha
|
multiple interactions affects binding
|
ISO
|
biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein] biochanin A binds to ESRRA protein mutant form
|
CTD |
PMID:14638870 |
|
NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811
|
|
G
|
Esrrb
|
estrogen-related receptor beta
|
multiple interactions
|
ISO
|
biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]
|
CTD |
PMID:14638870 |
|
NCBI chr 6:111,738,662...111,894,087
Ensembl chr 6:111,738,662...111,894,087
|
|
G
|
Esrrg
|
estrogen-related receptor gamma
|
multiple interactions
|
ISO
|
biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]
|
CTD |
PMID:14638870 |
|
NCBI chr13:101,699,043...102,316,877
Ensembl chr13:101,889,706...102,316,877
|
|
G
|
Fbl
|
fibrillarin
|
increases expression
|
ISO
|
biochanin A results in increased expression of FBL mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:92,597,258...92,606,506
|
|
G
|
Folr1
|
folate receptor alpha
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of FOLR1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669
|
|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
affects binding decreases activity decreases expression
|
ISO
|
biochanin A binds to G6PD protein biochanin A results in decreased activity of G6PD protein biochanin A results in decreased expression of G6PD mRNA
|
CTD |
PMID:38266663 |
|
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144
|
|
G
|
Gm2a
|
ganglioside GM2 activator
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of GM2A mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451
|
|
G
|
Gnai3
|
G protein subunit alpha i3
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of GNAI3 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 2:198,430,920...198,468,874
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of GPX1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein]
|
CTD |
PMID:22387535 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
|
|
G
|
Igf1
|
insulin-like growth factor 1
|
multiple interactions
|
EXP
|
[Fulvestrant co-treated with biochanin A] results in decreased expression of IGF1 mRNA
|
CTD |
PMID:34848279 |
|
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
|
CTD |
PMID:25583575 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
G
|
Il18
|
interleukin 18
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL18 protein]
|
CTD |
PMID:38764152 |
|
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
|
CTD |
PMID:38648921 PMID:38764152 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il4
|
interleukin 4
|
increases expression
|
ISO
|
biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein
|
CTD |
PMID:16169028 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]
|
CTD |
PMID:37016276 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Lck
|
LCK proto-oncogene, Src family tyrosine kinase
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein]
|
CTD |
PMID:22387535 |
|
NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267
|
|
G
|
Ldlrad4
|
low density lipoprotein receptor class A domain containing 4
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of LDLRAD4 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064
|
|
G
|
Lxn
|
latexin
|
increases expression
|
ISO
|
biochanin A results in increased expression of LXN mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 2:154,037,604...154,043,473
Ensembl chr 2:154,037,292...154,043,488
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:38764152 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:38764152 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MKI67 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
|
|
G
|
Mmp14
|
matrix metallopeptidase 14
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of MMP14 protein
|
CTD |
PMID:16598420 |
|
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
decreases activity decreases expression
|
ISO
|
biochanin A results in decreased activity of MMP2 protein biochanin A results in decreased expression of MMP2 mRNA
|
CTD |
PMID:16598420 PMID:38266663 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases activity decreases expression
|
ISO
|
biochanin A results in decreased activity of MMP9 protein biochanin A results in decreased expression of MMP9 mRNA
|
CTD |
PMID:16598420 PMID:38266663 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
|
CTD |
PMID:38648921 PMID:38764152 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Mt2
|
metallothionein 2
|
increases expression
|
ISO
|
biochanin A results in increased expression of MT2A mRNA
|
CTD |
PMID:10656621 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MTOR protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
|
|
G
|
Muc2
|
mucin 2, oligomeric mucus/gel-forming
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MUC2 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280
|
|
G
|
Ncoa1
|
nuclear receptor coactivator 1
|
multiple interactions
|
ISO
|
biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]
|
CTD |
PMID:25583575 |
|
NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924
|
|
G
|
Ndufa5
|
NADH:ubiquinone oxidoreductase subunit A5
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of NDUFA5 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA
|
CTD |
PMID:33410021 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein] biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:22387535 PMID:38764152 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Nono
|
non-POU domain containing, octamer-binding
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of NONO mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr X:70,594,116...70,611,976
Ensembl chr X:70,593,888...70,611,979
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
|
CTD |
PMID:38764152 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
|
CTD |
PMID:25257666 |
|
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions
|
ISO
|
biochanin A binds to and results in increased activity of NR1I2 protein
|
CTD |
PMID:33049310 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
|
|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
|
|
G
|
P2ry14
|
purinergic receptor P2Y14
|
decreases expression multiple interactions
|
EXP
|
biochanin A results in decreased expression of P2RY14 mRNA Fulvestrant inhibits the reaction [biochanin A results in decreased expression of P2RY14 mRNA]
|
CTD |
PMID:34848279 |
|
NCBI chr 2:145,522,598...145,563,074
Ensembl chr 2:145,516,390...145,564,788
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
biochanin A results in increased cleavage of PARP1 protein
|
CTD |
PMID:12791511 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of PCNA protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
|
|
G
|
Pfdn5
|
prefoldin subunit 5
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of PFDN5 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099
|
|
G
|
Pgr
|
progesterone receptor
|
affects binding multiple interactions increases expression
|
ISO EXP
|
biochanin A binds to PGR protein Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA] biochanin A inhibits the reaction [Progesterone binds to PGR protein]
|
CTD |
PMID:14579009 PMID:16076101 PMID:34848279 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
|
|
G
|
Plaur
|
plasminogen activator, urokinase receptor
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of PLAUR protein
|
CTD |
PMID:16598420 |
|
NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130
|
|
G
|
Pnrc1
|
proline-rich nuclear receptor coactivator 1
|
multiple interactions
|
ISO
|
biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]
|
CTD |
PMID:14638870 |
|
NCBI chr 5:52,443,400...52,489,303
Ensembl chr 5:52,443,400...52,446,491
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
biochanin A binds to and results in increased activity of PPARG protein
|
CTD |
PMID:33049310 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of PRKAA1 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein] biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
|
CTD |
PMID:22387535 PMID:38764152 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Rabl6
|
RAB, member RAS oncogene family-like 6
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of RABL6 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 3:28,800,802...28,826,722
Ensembl chr 3:28,800,802...28,826,722
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
decreases expression multiple interactions
|
ISO
|
biochanin A results in decreased expression of RELA mRNA biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]
|
CTD |
PMID:12111696 PMID:38764152 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Rif1
|
replication timing regulatory factor 1
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of RIF1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:56,963,854...57,017,106
|
|
G
|
Rorc
|
RAR-related orphan receptor C
|
multiple interactions
|
ISO
|
biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]
|
CTD |
PMID:25583575 |
|
NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566
|
|
G
|
Rpusd3
|
RNA pseudouridine synthase D3
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of RPUSD3 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 4:148,108,857...148,118,246
Ensembl chr 4:148,109,383...148,118,206
|
|
G
|
Sh3gl1
|
SH3 domain containing GRB2 like 1, endophilin A2
|
increases expression
|
ISO
|
biochanin A results in increased expression of SH3GL1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890
|
|
G
|
Slc16a1
|
solute carrier family 16 member 1
|
multiple interactions
|
EXP
|
[biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
|
CTD |
PMID:17108059 |
|
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977
|
|
G
|
Slc25a3
|
solute carrier family 25 member 3
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of SLC25A3 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:27,499,165...27,506,309
|
|
G
|
Slco1c1
|
solute carrier organic anion transporter family, member 1c1
|
decreases activity multiple interactions
|
EXP
|
biochanin A results in decreased activity of SLCO1B1 protein [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
|
CTD |
PMID:32259555 |
|
NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395
|
|
G
|
Sqstm1
|
sequestosome 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of SQSTM1 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
|
|
G
|
Srsf1
|
serine and arginine rich splicing factor 1
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of SRSF1 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr10:73,335,519...73,342,549
Ensembl chr10:73,336,422...73,342,548
|
|
G
|
Sult1a1
|
sulfotransferase family 1A member 1
|
increases expression
|
EXP
|
biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein
|
CTD |
PMID:20391625 |
|
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
|
|
G
|
Sult1e1
|
sulfotransferase family 1E member 1
|
increases expression
|
EXP
|
biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein
|
CTD |
PMID:20391625 |
|
NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716
|
|
G
|
Sult2a1
|
sulfotransferase family 2A member 1
|
increases expression
|
EXP
|
biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein
|
CTD |
PMID:20391625 |
|
NCBI chr 1:84,582,011...84,639,001
|
|
G
|
Susd6
|
sushi domain containing 6
|
increases expression
|
ISO
|
biochanin A results in increased expression of SUSD6 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 6:106,130,183...106,262,900
Ensembl chr 6:106,169,118...106,262,900
|
|
G
|
Syk
|
spleen associated tyrosine kinase
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein]
|
CTD |
PMID:22387535 |
|
NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278
|
|
G
|
Thrb
|
thyroid hormone receptor beta
|
multiple interactions
|
ISO
|
biochanin A binds to and results in increased activity of THRB protein
|
CTD |
PMID:33049310 |
|
NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP ISO
|
biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
|
CTD |
PMID:16735947 PMID:38648921 PMID:38764152 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tnfrsf21
|
TNF receptor superfamily member 21
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of TNFRSF21 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:25,376,400...25,451,323
|
|
G
|
Tubb5
|
tubulin, beta 5 class I
|
increases expression
|
ISO
|
biochanin A results in increased expression of TUBB mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
|
|
G
|
Tyr
|
tyrosinase
|
increases expression
|
ISO
|
biochanin A results in increased expression of TYR mRNA
|
CTD |
PMID:21071833 |
|
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
|
|
G
|
Ube2d2
|
ubiquitin-conjugating enzyme E2D 2
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of UBE2D2 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,638,527...27,683,074
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
increases glucuronidation increases expression
|
ISO
|
UGT1A1 protein results in increased glucuronidation of biochanin A biochanin A results in increased expression of UGT1A1 mRNA
|
CTD |
PMID:14557274 PMID:31621310 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases glucuronidation
|
ISO
|
UGT1A9 protein results in increased glucuronidation of biochanin A
|
CTD |
PMID:14557274 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ulk1
|
unc-51 like autophagy activating kinase 1
|
multiple interactions
|
ISO
|
biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of ULK1 protein]
|
CTD |
PMID:38648921 |
|
NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746
|
|
G
|
Vcam1
|
vascular cell adhesion molecule 1
|
multiple interactions decreases expression
|
EXP
|
biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein]
|
CTD |
PMID:16223672 PMID:16735947 |
|
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
|
|
G
|
Wdr74
|
WD repeat domain 74
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of WDR74 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr 1:215,060,901...215,065,687
Ensembl chr 1:215,060,961...215,066,336
|
|
G
|
Wwc2
|
WW and C2 domain containing 2
|
decreases expression
|
ISO
|
biochanin A results in decreased expression of WWC2 mRNA
|
CTD |
PMID:12111696 |
|
NCBI chr16:50,991,096...51,154,529
Ensembl chr16:50,991,096...51,154,526
|
|
|
G
|
Abhd14b
|
abhydrolase domain containing 14b
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ABHD14B protein
|
CTD |
PMID:24455688 |
|
NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833
|
|
G
|
Ache
|
acetylcholinesterase
|
increases expression multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ACHE mRNA 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in increased activity of ACHE protein
|
CTD |
PMID:27019979 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Ager
|
advanced glycosylation end product-specific receptor
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of AGER protein]
|
CTD |
PMID:36195188 |
|
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of APP protein]
|
CTD |
PMID:36195188 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Atp5f1a
|
ATP synthase F1 subunit alpha
|
increases expression multiple interactions
|
EXP ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ATP5F1A mRNA 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein] 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]
|
CTD |
PMID:36436616 |
|
NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
|
|
G
|
Bace1
|
beta-secretase 1
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of BACE1 protein]
|
CTD |
PMID:36195188 |
|
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
|
|
G
|
Blvrb
|
biliverdin reductase B
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of BLVRB protein
|
CTD |
PMID:24455688 |
|
NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:91,866,258...91,884,225
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of CASP3 protein]
|
CTD |
PMID:36195188 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Ccnb1
|
cyclin B1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNB1 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
|
|
G
|
Ccnd3
|
cyclin D3
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CCND3 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033
|
|
G
|
Ccng1
|
cyclin G1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNG1 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766
|
|
G
|
Cdk7
|
cyclin-dependent kinase 7
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CDK7 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1A mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Cdkn1c
|
cyclin-dependent kinase inhibitor 1C
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1C mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498
|
|
G
|
Cdkn2d
|
cyclin dependent kinase inhibitor 2D
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN2D mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:28,108,044...28,110,809
|
|
G
|
Epo
|
erythropoietin
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of EPO mRNA
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
|
|
G
|
Erp29
|
endoplasmic reticulum protein 29
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ERP29 protein
|
CTD |
PMID:24455688 |
|
NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:36195188 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased degradation of and results in increased expression of HIF1A protein modified form; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in decreased degradation of HIF1A protein 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A mRNA; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A protein
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Hmgb1
|
high mobility group box 1
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il1rl1
|
interleukin 1 receptor-like 1
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA]
|
CTD |
PMID:31726037 |
|
NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
|
|
G
|
Il33
|
interleukin 33
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Krt1
|
keratin 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of KRT1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537
|
|
G
|
Lasp1
|
LIM and SH3 protein 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of LASP1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr10:83,290,820...83,331,989
Ensembl chr10:83,290,865...83,331,988
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
increases phosphorylation
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK1 protein
|
CTD |
PMID:20686605 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK3 protein
|
CTD |
PMID:20686605 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapt
|
microtubule-associated protein tau
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased phosphorylation of MAPT protein]
|
CTD |
PMID:36195188 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
|
|
G
|
Mcm5
|
minichromosome maintenance complex component 5
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of MCM5 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758
|
|
G
|
Mcm6
|
minichromosome maintenance complex component 6
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of MCM6 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467
|
|
G
|
Ndufb8
|
NADH:ubiquinone oxidoreductase subunit B8
|
multiple interactions
|
EXP ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]
|
CTD |
PMID:36436616 |
|
NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nme1
|
NME/NM23 nucleoside diphosphate kinase 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of NME1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310
|
|
G
|
Nrf1
|
nuclear respiratory factor 1
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NRF1 protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]]
|
CTD |
PMID:36436616 |
|
NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353
|
|
G
|
Pebp1
|
phosphatidylethanolamine binding protein 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PEBP1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780
|
|
G
|
Pgam1
|
phosphoglycerate mutase 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PGAM1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203
|
|
G
|
Pnpo
|
pyridoxamine 5'-phosphate oxidase
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PNPO protein
|
CTD |
PMID:24455688 |
|
NCBI chr10:82,421,027...82,427,288
Ensembl chr10:82,421,027...82,427,288
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of PPARGC1A protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of and affects the localization of PPARGC1A protein]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of PPARGC1A protein]]
|
CTD |
PMID:36195188 PMID:36436616 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
G
|
Prdx1
|
peroxiredoxin 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRDX1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504
|
|
G
|
Prdx2
|
peroxiredoxin 2
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of PRDX2 protein
|
CTD |
PMID:24455688 |
|
NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006
|
|
G
|
Prima1
|
proline rich membrane anchor 1
|
increases expression
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRIMA1 mRNA
|
CTD |
PMID:27019979 |
|
NCBI chr 6:128,094,686...128,155,592
Ensembl chr 6:128,103,175...128,154,865
|
|
G
|
Ptgr1
|
prostaglandin reductase 1
|
increases expression
|
ISO
|
[Calycosin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells
|
RGD |
PMID:26265982 |
RGD:401959214 |
NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811
|
|
G
|
Rad9a
|
RAD9 checkpoint clamp component A
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of RAD9A mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:210,917,970...210,925,161
|
|
G
|
Rbx1
|
ring-box 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of RBX1 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of RELA protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Sdhb
|
succinate dehydrogenase complex iron sulfur subunit B
|
multiple interactions
|
ISO EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein] 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]
|
CTD |
PMID:36436616 |
|
NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667
|
|
G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein]
|
CTD |
PMID:36436616 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
G
|
Skp1
|
S-phase kinase-associated protein 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of SKP1 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308
|
|
G
|
Skp2
|
S-phase kinase associated protein 2
|
decreases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of SKP2 mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438
|
|
G
|
Stip1
|
stress-induced phosphoprotein 1
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of STIP1 protein
|
CTD |
PMID:24455688 |
|
NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654
|
|
G
|
Tagln2
|
transgelin 2
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of TAGLN2 protein
|
CTD |
PMID:24455688 |
|
NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330
|
|
G
|
Tfam
|
transcription factor A, mitochondrial
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of TFAM protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM protein]
|
CTD |
PMID:36195188 PMID:36436616 |
|
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]
|
CTD |
PMID:31726037 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]
|
CTD |
PMID:31726037 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tnni3
|
troponin I3, cardiac type
|
multiple interactions
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased expression of TNNI3 protein]
|
CTD |
PMID:36436616 |
|
NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
|
|
G
|
Ube3a
|
ubiquitin protein ligase E3A
|
increases expression
|
ISO
|
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UBE3A mRNA
|
CTD |
PMID:24455688 |
|
NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
increases glucuronidation
|
ISO
|
UGT1A1 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone
|
CTD |
PMID:25044472 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt1a2
|
UDP glucuronosyltransferase 1 family, polypeptide A2
|
increases glucuronidation
|
ISO
|
UGT1A3 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone
|
CTD |
PMID:25044472 |
|
NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases glucuronidation
|
ISO
|
UGT1A9 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone
|
CTD |
PMID:25044472 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt2b7
|
UDP glucuronosyltransferase family 2 member B7
|
increases glucuronidation
|
ISO
|
UGT2B7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone
|
CTD |
PMID:25044472 |
|
NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
|
|
G
|
Uqcrc2
|
ubiquinol cytochrome c reductase core protein 2
|
multiple interactions increases expression
|
ISO EXP
|
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein] 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]] 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UQCRC2 mRNA
|
CTD |
PMID:36436616 |
|
NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946
|
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
ISO
|
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein] calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein
|
CTD |
PMID:36812960 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions decreases expression
|
ISO
|
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein] calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein
|
CTD |
PMID:36812960 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Casp3
|
caspase 3
|
increases cleavage multiple interactions increases expression
|
ISO
|
calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]
|
CTD |
PMID:36812960 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Cat
|
catalase
|
decreases expression
|
ISO
|
calycosin-7-O-beta-D-glucoside results in decreased expression of CAT protein
|
CTD |
PMID:36812960 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Epo
|
erythropoietin
|
increases expression
|
ISO
|
calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
decreases expression
|
ISO
|
calycosin-7-O-beta-D-glucoside results in decreased expression of GPT protein
|
CTD |
PMID:36812960 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions increases expression
|
ISO
|
calycosin-7-O-beta-D-glucoside results in decreased degradation of and results in increased expression of HIF1A protein modified form; calycosin-7-O-beta-D-glucoside results in increased expression of and results in decreased degradation of HIF1A protein calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A protein
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Txn1
|
thioredoxin 1
|
multiple interactions decreases expression
|
ISO
|
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA] calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein calycosin-7-O-beta-D-glucoside results in decreased expression of TXN mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein
|
CTD |
PMID:36812960 |
|
NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions decreases activity increases expression affects activity
|
ISO
|
Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] formononetin results in decreased activity of ABCB1 protein formononetin affects the activity of ABCB1 protein
|
CTD |
PMID:15796199 PMID:23867903 PMID:27996361 PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
affects activity decreases expression multiple interactions
|
ISO
|
formononetin affects the activity of ABCC1 protein formononetin results in decreased expression of ABCC1 mRNA Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]
|
CTD |
PMID:15796199 PMID:23867903 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
multiple interactions decreases expression
|
ISO EXP
|
Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA] formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]
|
CTD |
PMID:23867903 PMID:28414026 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
G
|
Abcc4
|
ATP binding cassette subfamily C member 4
|
multiple interactions
|
EXP
|
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]
|
CTD |
PMID:28414026 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
|
|
G
|
Acp5
|
acid phosphatase 5, tartrate resistant
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased activity of ACP5 protein]; formononetin inhibits the reaction [Streptozocin results in increased expression of ACP5 mRNA]
|
CTD |
PMID:35315182 |
|
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
multiple interactions increases activity
|
ISO
|
fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein]
|
CTD |
PMID:28985473 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
Akr1b10
|
aldo-keto reductase family 1 member B10
|
increases expression
|
ISO
|
formononetin results in increased expression of AKR1B10 mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions decreases phosphorylation
|
ISO
|
formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]] formononetin decreases phosphorylation of AKT1 protein in lung
|
CTD RGD |
PMID:34077701 PMID:32276600 |
RGD:151357000 |
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
ISO EXP
|
formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA] formononetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
|
CTD |
PMID:23867903 PMID:28414026 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression multiple interactions
|
ISO EXP
|
formononetin results in decreased expression of BCL2 mRNA formononetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] formononetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
|
CTD |
PMID:23867903 PMID:28414026 PMID:34077701 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Birc2
|
baculoviral IAP repeat-containing 2
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of BIRC2 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases activity increases expression
|
ISO EXP
|
Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA] formononetin increases activity of CASP3 protein in lung formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]
|
CTD RGD |
PMID:23867903 PMID:28414026 PMID:34077701 PMID:32276600 |
RGD:151357000 |
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp7
|
caspase 7
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein]
|
CTD |
PMID:34077701 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions increases expression increases activity
|
ISO
|
Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]
|
CTD |
PMID:23867903 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases expression increases activity
|
ISO
|
Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]
|
CTD |
PMID:23867903 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Ccnb1
|
cyclin B1
|
increases expression multiple interactions
|
ISO EXP
|
formononetin results in increased expression of CCNB1 protein XI-006 inhibits the reaction [formononetin results in increased expression of CCNB1 protein]
|
CTD |
PMID:28414026 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
|
|
G
|
Ccnd1
|
cyclin D1
|
increases expression multiple interactions
|
EXP ISO
|
formononetin results in increased expression of CCND1 protein XI-006 inhibits the reaction [formononetin results in increased expression of CCND1 protein]
|
CTD |
PMID:28414026 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
increases expression
|
ISO
|
formononetin results in increased expression of CPT1A mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
|
|
G
|
Ctsk
|
cathepsin K
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK protein]
|
CTD |
PMID:35315182 |
|
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
increases hydroxylation increases expression multiple interactions decreases methylation
|
ISO
|
CYP1A1 protein results in increased hydroxylation of formononetin formononetin results in increased expression of CYP1A1 mRNA fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA] CYP1A1 protein results in decreased methylation of formononetin
|
CTD |
PMID:15479032 PMID:28985473 PMID:37793997 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
decreases activity
|
ISO EXP
|
formononetin results in decreased activity of CYP1A2 protein
|
CTD |
PMID:26278343 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
decreases methylation increases expression
|
ISO
|
CYP1B1 protein results in decreased methylation of formononetin formononetin results in increased expression of CYP1B1 mRNA
|
CTD |
PMID:15479032 PMID:28985473 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
decreases activity
|
ISO
|
formononetin results in decreased activity of CYP2D6 protein
|
CTD |
PMID:26278343 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
|
|
G
|
Egfr
|
epidermal growth factor receptor
|
decreases phosphorylation
|
ISO
|
formononetin decreases phosphorylation of EGFR protein in lung
|
RGD |
PMID:32276600 |
RGD:151357000 |
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
|
|
G
|
Epo
|
erythropoietin
|
increases expression
|
ISO
|
formononetin results in increased expression of EPO mRNA
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
|
|
G
|
Esr1
|
estrogen receptor 1
|
affects binding multiple interactions
|
ISO
|
formononetin binds to ESR1 protein [Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein formononetin binds to and results in increased activity of ESR1 protein
|
CTD |
PMID:9751507 PMID:16076101 PMID:16773531 PMID:37269934 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions affects binding
|
ISO
|
formononetin binds to and results in increased activity of ESR2 protein formononetin binds to ESR2 protein
|
CTD |
PMID:9751507 PMID:12224631 PMID:16076101 PMID:16773531 PMID:19913605 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased expression of FOS mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of FOS protein]
|
CTD |
PMID:35315182 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of GCLM protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]
|
CTD |
PMID:34077701 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Havcr1
|
hepatitis A virus cellular receptor 1
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]
|
CTD |
PMID:28414026 |
|
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
increases expression multiple interactions
|
ISO
|
formononetin results in increased expression of HIF1A mRNA; formononetin results in increased expression of HIF1A protein formononetin results in decreased degradation of and results in increased expression of HIF1A protein modified form; formononetin results in increased expression of and results in decreased degradation of HIF1A protein
|
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO EXP
|
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]] formononetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]
|
CTD |
PMID:34077701 PMID:37944786 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
formononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
|
CTD |
PMID:25583575 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
|
CTD |
PMID:39855309 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il4
|
interleukin 4
|
increases expression
|
ISO
|
formononetin results in increased expression of IL4 mRNA; formononetin results in increased expression of IL4 protein
|
CTD |
PMID:16108819 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
|
CTD |
PMID:37269934 PMID:39855309 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased expression of JUN mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of JUN protein]
|
CTD |
PMID:35315182 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:34077701 PMID:39855309 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk11
|
mitogen-activated protein kinase 11
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK11 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK11 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038
|
|
G
|
Mapk12
|
mitogen-activated protein kinase 12
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK12 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK12 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307
|
|
G
|
Mapk13
|
mitogen activated protein kinase 13
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK13 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK13 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191
|
|
G
|
Mapk14
|
mitogen activated protein kinase 14
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK14 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:34077701 PMID:39855309 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK8 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:34077701 PMID:39855309 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Matn3
|
matrilin 3
|
decreases expression
|
ISO
|
formononetin results in decreased expression of MATN3 mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 6:37,467,729...37,487,776
Ensembl chr 6:37,467,729...37,487,776
|
|
G
|
Mcl1
|
MCL1 apoptosis regulator, BCL2 family member
|
decreases expression
|
ISO
|
formononetin decreases expression of MCL1 protein in lung
|
RGD |
PMID:32276600 |
RGD:151357000 |
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
|
|
G
|
Mdm2
|
MDM2 proto-oncogene
|
increases expression
|
EXP
|
formononetin results in increased expression of MDM2 protein
|
CTD |
PMID:28414026 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
|
|
G
|
Mdm4
|
MDM4 regulator of p53
|
increases expression
|
EXP
|
formononetin results in increased expression of MDM4 protein
|
CTD |
PMID:28414026 |
|
NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]
|
CTD |
PMID:35315182 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Nfatc1
|
nuclear factor of activated T-cells 1
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 protein]
|
CTD |
PMID:35315182 |
|
NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]] formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]
|
CTD |
PMID:34077701 PMID:37269934 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [CXCL8 protein results in increased phosphorylation of NFKBIA protein] formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:22387535 PMID:39855309 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Ngf
|
nerve growth factor
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of NGF mRNA]; formononetin inhibits the reaction [Glucose results in decreased secretion of and results in decreased expression of NGF protein]
|
CTD |
PMID:37944786 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
|
|
G
|
Nlrp3
|
NLR family, pyrin domain containing 3
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
|
CTD |
PMID:37269934 PMID:39855309 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
|
CTD |
PMID:39855309 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
increases expression multiple interactions
|
EXP
|
formononetin results in increased expression of NOS3 mRNA formononetin results in increased phosphorylation of and results in increased activity of NOS3 protein
|
CTD |
PMID:19570671 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO
|
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]
|
CTD |
PMID:34077701 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
|
|
G
|
Pgc
|
progastricsin
|
decreases expression
|
ISO
|
formononetin results in decreased expression of PGC mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 9:20,755,002...20,763,220
Ensembl chr 9:20,755,002...20,763,220
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in decreased localization of PPARG protein]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased localization of PPARG protein]
|
CTD |
PMID:39855309 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]
|
CTD |
PMID:37944786 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
increases phosphorylation multiple interactions
|
ISO
|
formononetin results in increased phosphorylation of PRKAA1 protein Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein]
|
CTD |
PMID:37269934 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
|
|
G
|
Prkaa2
|
protein kinase AMP-activated catalytic subunit alpha 2
|
multiple interactions increases phosphorylation
|
ISO
|
Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA2 protein]
|
CTD |
PMID:37269934 |
|
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
|
|
G
|
Prkacb
|
protein kinase cAMP-activated catalytic subunit beta
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of PRKACB protein
|
CTD |
PMID:37269934 |
|
NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315
|
|
G
|
Ptgr1
|
prostaglandin reductase 1
|
increases expression
|
ISO
|
[Formononetin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells
|
RGD |
PMID:26265982 |
RGD:401959214 |
NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
|
CTD |
PMID:37269934 PMID:39855309 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased localization of RELA protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of RELA protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]
|
CTD |
PMID:39855309 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]
|
CTD |
PMID:37944786 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
G
|
Sirt3
|
sirtuin 3
|
affects binding multiple interactions
|
EXP
|
formononetin binds to SIRT3 protein formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]
|
CTD |
PMID:37944786 |
|
NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076
|
|
G
|
Slc22a2
|
solute carrier family 22 member 2
|
decreases expression
|
EXP
|
formononetin results in decreased expression of SLC22A2 mRNA
|
CTD |
PMID:28414026 |
|
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
|
|
G
|
Slc6a14
|
solute carrier family 6 member 14
|
decreases expression
|
ISO
|
formononetin results in decreased expression of SLC6A14 mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr X:117,109,063...117,169,522
Ensembl chr X:117,108,947...117,169,828
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 protein]
|
CTD |
PMID:37944786 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP ISO
|
formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 protein] formononetin inhibits the reaction [Dextran Sulfate results in decreased expression of SOD2 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 protein]
|
CTD |
PMID:37944786 PMID:39855309 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Stk11
|
serine/threonine kinase 11
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein
|
CTD |
PMID:37269934 |
|
NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965
|
|
G
|
Tagln
|
transgelin
|
decreases expression
|
ISO
|
formononetin results in decreased expression of TAGLN mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563
|
|
G
|
Tfam
|
transcription factor A, mitochondrial
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of TFAM mRNA]
|
CTD |
PMID:37944786 |
|
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
|
|
G
|
Tfb2m
|
transcription factor B2, mitochondrial
|
multiple interactions
|
EXP
|
formononetin inhibits the reaction [Glucose results in decreased expression of TFB2M mRNA]
|
CTD |
PMID:37944786 |
|
NCBI chr13:93,810,859...93,828,678
Ensembl chr13:93,810,731...93,828,594
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
|
CTD |
PMID:37269934 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of TNF protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
|
CTD |
PMID:39855309 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions decreases expression
|
EXP ISO
|
formononetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] formononetin results in decreased expression of TP53 protein XI-006 inhibits the reaction [formononetin results in decreased expression of TP53 protein]
|
CTD |
PMID:28414026 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
G
|
Trpv5
|
transient receptor potential cation channel, subfamily V, member 5
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV5 mRNA]
|
CTD |
PMID:35315182 |
|
NCBI chr 4:71,503,085...71,531,134
Ensembl chr 4:71,503,093...71,529,384
|
|
G
|
Trpv6
|
transient receptor potential cation channel, subfamily V, member 6
|
multiple interactions
|
ISO
|
formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA]
|
CTD |
PMID:35315182 |
|
NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:71,474,007...71,489,671
|
|
G
|
Txnip
|
thioredoxin interacting protein
|
increases expression
|
ISO
|
formononetin results in increased expression of TXNIP mRNA
|
CTD |
PMID:37793997 |
|
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
|
|
G
|
Txnrd1
|
thioredoxin reductase 1
|
multiple interactions
|
ISO
|
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]
|
CTD |
PMID:34077701 |
|
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
increases glucuronidation increases expression
|
ISO
|
UGT1A1 protein results in increased glucuronidation of formononetin formononetin results in increased expression of UGT1A1 mRNA
|
CTD |
PMID:14557274 PMID:37793997 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases glucuronidation
|
ISO
|
UGT1A9 protein results in increased glucuronidation of formononetin
|
CTD |
PMID:14557274 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
|
G
|
Abca1
|
ATP binding cassette subfamily A member 1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions
|
ISO
|
glycitein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
|
CTD |
PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Acsl3
|
acyl-CoA synthetase long-chain family member 3
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097
|
|
G
|
Add2
|
adducin 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 4:120,001,977...120,101,090
Ensembl chr 4:120,002,054...120,101,091
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
increases activity
|
ISO
|
glycitein results in increased activity of AHR protein
|
CTD |
PMID:17869316 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
Aldh1a2
|
aldehyde dehydrogenase 1 family, member A2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883
|
|
G
|
Anpep
|
alanyl aminopeptidase, membrane
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101
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|
G
|
Arhgdia
|
Rho GDP dissociation inhibitor alpha
|
decreases expression
|
ISO
|
glycitein results in decreased expression of ARHGDIA mRNA
|
CTD |
PMID:15757668 |
|
NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347
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|
G
|
Atoh8
|
atonal bHLH transcription factor 8
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379
|
|
G
|
Atp6v0a2
|
ATPase H+ transporting V0 subunit a2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ATP6V0A2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr12:37,608,211...37,640,860
Ensembl chr12:37,472,813...37,640,860
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|
G
|
Baz1a
|
bromodomain adjacent to zinc finger domain, 1A
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 6:78,124,872...78,247,672
Ensembl chr 6:78,124,872...78,247,648
|
|
G
|
Bckdk
|
branched chain ketoacid dehydrogenase kinase
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453
|
|
G
|
Bpgm
|
bisphosphoglycerate mutase
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627
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G
|
Cabp5
|
calcium binding protein 5
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:83,486,396...83,499,421
Ensembl chr 1:83,486,396...83,499,421
|
|
G
|
Cacybp
|
calcyclin binding protein
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505
|
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G
|
Casp8ap2
|
caspase 8 associated protein 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632
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G
|
Ccna2
|
cyclin A2
|
decreases expression
|
ISO
|
glycitein results in decreased expression of CCNA2
|
CTD |
PMID:21161820 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
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G
|
Ccnd1
|
cyclin D1
|
increases expression
|
ISO
|
glycitein results in increased expression of CCND1 mRNA
|
CTD |
PMID:19800779 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cd200r1
|
CD200 receptor 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr11:69,392,943...69,427,213
Ensembl chr11:69,392,975...69,427,128
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|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
decreases activity
|
ISO
|
glycitein results in decreased activity of CDK4 protein
|
CTD |
PMID:21161820 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
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G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
multiple interactions increases expression
|
ISO
|
ESR2 affects the reaction [glycitein results in increased expression of CDKN1A]
|
CTD |
PMID:21161820 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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|
G
|
Cfap251
|
cilia and flagella associated protein 251
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:38,923,154...38,997,881
Ensembl chr12:38,922,330...38,954,783
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|
G
|
Cybrd1
|
cytochrome b reductase 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061
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G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
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|
G
|
Dennd2d
|
DENN domain containing 2D
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397
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G
|
Dnmt1
|
DNA methyltransferase 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
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G
|
Dnmt3a
|
DNA methyltransferase 3 alpha
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970
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G
|
Dock3
|
dedicator of cyto-kinesis 3
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 8:116,431,158...116,782,218
Ensembl chr 8:116,431,159...116,782,195
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G
|
Dpp9
|
dipeptidyl peptidase 9
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715
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G
|
Edrf1
|
erythroid differentiation regulatory factor 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:197,869,873...197,908,693
Ensembl chr 1:197,870,962...197,908,731
|
|
G
|
Efhd1
|
EF-hand domain family, member D1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798
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|
G
|
Epha1
|
Eph receptor A1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474
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G
|
Espn
|
espin
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ESPN mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 5:167,909,271...167,943,168
Ensembl chr 5:167,909,271...167,942,984
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions affects binding
|
ISO
|
glycitein inhibits the reaction [Estradiol binds to ESR1 protein] glycitein binds to ESR1 protein
|
CTD |
PMID:14579009 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions affects response to substance
|
ISO EXP
|
ESR2 affects the reaction [glycitein results in increased expression of CDKN1A] [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA ESR2 affects the susceptibility to glycitein
|
CTD |
PMID:21161820 PMID:28964809 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
|
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G
|
Fam171a2
|
family with sequence similarity 171, member A2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,893,543...87,904,247
|
|
G
|
Fam180a
|
family with sequence similarity 180, member A
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:64,959,999...64,975,176
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|
G
|
Fam210b
|
family with sequence similarity 210, member B
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:181,536,673...181,546,834
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G
|
Fam241b
|
family with sequence similarity 241 member B
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,595,084...30,597,844 Ensembl chr 6:30,595,084...30,597,844
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G
|
Fgd6
|
FYVE, RhoGEF and PH domain containing 6
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806
|
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G
|
Fhl2
|
four and a half LIM domains 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326
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|
G
|
Fmn2
|
formin 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr13:88,986,863...89,303,789
Ensembl chr13:88,986,842...89,303,789
|
|
G
|
Galnt15
|
polypeptide N-acetylgalactosaminyltransferase 15
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr16:7,233,524...7,273,290
Ensembl chr16:7,233,606...7,273,285
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G
|
Gng5
|
G protein subunit gamma 5
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:238,054,954...238,063,451
Ensembl chr11:58,096,362...58,096,565 Ensembl chr 2:58,096,362...58,096,565
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G
|
Hipk4
|
homeodomain interacting protein kinase 4
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:91,938,278...91,948,683
|
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G
|
Hmcn1
|
hemicentin 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519
|
|
G
|
Hsd3b1
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 2:188,858,574...188,864,694
|
|
G
|
Ifrd2
|
interferon-related developmental regulator 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IFRD2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:117,139,550...117,144,836
|
|
G
|
Il6r
|
interleukin 6 receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
|
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G
|
Irf2bp1
|
interferon regulatory factor 2 binding protein 1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IRF2BP1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 1:87,780,782...87,783,483
Ensembl chr 1:87,779,406...87,785,661
|
|
G
|
Isg20l2
|
interferon stimulated exonuclease gene 20-like 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:175,695,615...175,705,095
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
increases activity
|
ISO
|
glycitein results in increased activity of JUN protein
|
CTD |
PMID:17088408 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Kcng2
|
potassium voltage-gated channel modifier subfamily G member 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr18:76,017,225...76,085,377
Ensembl chr18:76,018,047...76,083,688
|
|
G
|
Kdm5a
|
lysine demethylase 5A
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121
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|
G
|
Kitlg
|
KIT ligand
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793
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|
G
|
Knstrn
|
kinetochore-localized astrin/SPAG5 binding protein
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418
|
|
G
|
Ldlrap1
|
low density lipoprotein receptor adaptor protein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:152,229,505...152,262,290
|
|
G
|
Lmod1
|
leiomodin 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116
|
|
G
|
Lrg1
|
leucine-rich alpha-2-glycoprotein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337
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|
G
|
Lsr
|
lipolysis stimulated lipoprotein receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:95,313,033...95,329,354
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions increases phosphorylation
|
ISO
|
glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] glycitein results in increased phosphorylation of MAPK1 protein
|
CTD |
PMID:17088408 PMID:20188714 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions increases phosphorylation
|
ISO
|
glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] glycitein results in increased phosphorylation of MAPK3 protein
|
CTD |
PMID:17088408 PMID:20188714 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
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Mmp3
|
matrix metallopeptidase 3
|
decreases expression
|
ISO
|
glycitein results in decreased expression of MMP3 mRNA; glycitein results in decreased expression of MMP3 protein
|
CTD |
PMID:20188714 |
|
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
|
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G
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Mmp9
|
matrix metallopeptidase 9
|
multiple interactions decreases expression
|
ISO
|
glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein] glycitein results in decreased expression of MMP9 mRNA; glycitein results in decreased expression of MMP9 protein
|
CTD |
PMID:20188714 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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G
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Mrpl33
|
mitochondrial ribosomal protein L33
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987
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G
|
Mtmr11
|
myotubularin related protein 11
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026
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G
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Myof
|
myoferlin
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768
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G
|
Nos2
|
nitric oxide synthase 2
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multiple interactions decreases activity
|
ISO
|
glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] glycitein results in decreased activity of NOS2 protein
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CTD |
PMID:11308324 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
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Nr4a1
|
nuclear receptor subfamily 4, group A, member 1
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
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G
|
Nr5a1
|
nuclear receptor subfamily 5, group A, member 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]
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CTD |
PMID:28964809 |
|
NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046
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G
|
Nrip1
|
nuclear receptor interacting protein 1
|
increases expression
|
ISO
|
glycitein results in increased expression of NRIP1 mRNA
|
CTD |
PMID:15757668 |
|
NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353
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G
|
Olfml3
|
olfactomedin-like 3
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of OLFML3 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:193,932,665...193,935,494
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
decreases expression
|
ISO
|
glycitein results in decreased expression of PCNA
|
CTD |
PMID:21161820 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
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G
|
Pdlim2
|
PDZ and LIM domain 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958
|
|
G
|
Pnn
|
pinin, desmosome associated protein
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multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PNN mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933
|
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G
|
Pou4f2
|
POU class 4 homeobox 2
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr19:46,390,958...46,394,599
Ensembl chr19:46,390,958...46,394,599
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G
|
Prkaca
|
protein kinase cAMP-activated catalytic subunit alpha
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494
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G
|
Prpf40a
|
pre-mRNA processing factor 40 homolog A
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363
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G
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Pspc1
|
paraspeckle component 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828
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G
|
Pth1r
|
parathyroid hormone 1 receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108
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G
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Rassf5
|
Ras association domain family member 5
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277
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G
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Rgs22
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regulator of G-protein signaling 22
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:69,073,681...69,194,041
Ensembl chr 7:69,075,562...69,194,102
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G
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Rps6ka3
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ribosomal protein S6 kinase A3
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increases expression
|
ISO
|
glycitein results in increased expression of RPS6KA3 mRNA
|
CTD |
PMID:15757668 |
|
NCBI chr X:39,325,926...39,432,017
Ensembl chr X:39,325,926...39,433,678
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G
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S1pr3
|
sphingosine-1-phosphate receptor 3
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,928,444...13,947,197
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G
|
Selplg
|
selectin P ligand
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:48,457,102...48,470,444
Ensembl chr12:48,456,932...48,473,154
|
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G
|
Sgpp1
|
sphingosine-1-phosphate phosphatase 1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259
|
|
G
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Siglec10
|
sialic acid binding Ig-like lectin 10
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SIGLEC10 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:102,953,894...102,962,964
Ensembl chr 1:102,953,918...102,962,964
|
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G
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Slc12a2
|
solute carrier family 12 member 2
|
decreases expression
|
ISO
|
glycitein results in decreased expression of SLC12A2 mRNA
|
CTD |
PMID:15757668 |
|
NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470
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G
|
Slc16a1
|
solute carrier family 16 member 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977
|
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G
|
Slc22a8
|
solute carrier family 22 member 8
|
increases uptake
|
ISO
|
SLC22A8 protein results in increased uptake of glycitein analog
|
CTD |
PMID:21244849 |
|
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
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G
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Snx30
|
sorting nexin family member 30
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:79,478,804...79,608,118
Ensembl chr 5:79,478,912...79,607,052
|
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G
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Sp1
|
Sp1 transcription factor
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multiple interactions increases activity
|
ISO
|
glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]
|
CTD |
PMID:17088408 |
|
NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513
|
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G
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Ssc5d
|
scavenger receptor cysteine rich family member with 5 domains
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:77,920,781...77,939,284
Ensembl chr 1:77,920,783...77,938,574
|
|
G
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Star
|
steroidogenic acute regulatory protein
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein
|
CTD |
PMID:28964809 |
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
|
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G
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Stc1
|
stanniocalcin 1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082
|
|
G
|
Styxl1
|
serine/threonine/tyrosine interacting-like 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:26,544,059...26,576,365
Ensembl chr12:26,544,067...26,576,366
|
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G
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Sumo1
|
small ubiquitin-like modifier 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890
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G
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Tacr3
|
tachykinin receptor 3
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:225,940,444...226,037,756
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G
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Tc2n
|
tandem C2 domains, nuclear
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:126,526,009...126,614,215
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G
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Tnfaip6
|
TNF alpha induced protein 6
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of TNFAIP6 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796
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G
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Tp53
|
tumor protein p53
|
increases expression
|
ISO
|
glycitein results in increased expression of TP53 protein
|
CTD |
PMID:19800779 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
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G
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Tp53i11
|
tumor protein p53 inducible protein 11
|
decreases expression multiple interactions
|
ISO
|
glycitein results in decreased expression of TP53I11 mRNA [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA
|
CTD |
PMID:15757668 PMID:27424125 |
|
NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:99,600,159...99,615,432
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G
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Uchl1
|
ubiquitin C-terminal hydrolase L1
|
multiple interactions
|
ISO
|
[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA
|
CTD |
PMID:16963248 |
|
NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417
|
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G
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Vcpip1
|
valosin containing protein interacting protein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778
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G
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Vdr
|
vitamin D receptor
|
multiple interactions increases expression
|
ISO
|
fulvestrant inhibits the reaction [glycitein results in increased expression of VDR protein]; glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased expression of VDR protein] glycitein results in increased expression of VDR mRNA; glycitein results in increased expression of VDR protein
|
CTD |
PMID:17088408 |
|
NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757
|
|
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G
|
Acsl3
|
acyl-CoA synthetase long-chain family member 3
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097
|
|
G
|
Aldh1a2
|
aldehyde dehydrogenase 1 family, member A2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883
|
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G
|
Anpep
|
alanyl aminopeptidase, membrane
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
EXP
|
glycitin inhibits the reaction [APP protein binds to APP protein]
|
CTD |
PMID:17323972 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
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|
G
|
Atoh8
|
atonal bHLH transcription factor 8
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379
|
|
G
|
Bckdk
|
branched chain ketoacid dehydrogenase kinase
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453
|
|
G
|
Bpgm
|
bisphosphoglycerate mutase
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627
|
|
G
|
Cabp5
|
calcium binding protein 5
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:83,486,396...83,499,421
Ensembl chr 1:83,486,396...83,499,421
|
|
G
|
Cacybp
|
calcyclin binding protein
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505
|
|
G
|
Casp8ap2
|
caspase 8 associated protein 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632
|
|
G
|
Cd200r1
|
CD200 receptor 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr11:69,392,943...69,427,213
Ensembl chr11:69,392,975...69,427,128
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G
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Cfap251
|
cilia and flagella associated protein 251
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:38,923,154...38,997,881
Ensembl chr12:38,922,330...38,954,783
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G
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Cybrd1
|
cytochrome b reductase 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA
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CTD |
PMID:27424125 |
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NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061
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G
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Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA
|
CTD |
PMID:28964809 |
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NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
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G
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Dennd2d
|
DENN domain containing 2D
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397
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G
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Dnmt1
|
DNA methyltransferase 1
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multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
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G
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Dnmt3a
|
DNA methyltransferase 3 alpha
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970
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G
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Dpp9
|
dipeptidyl peptidase 9
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715
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G
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Edrf1
|
erythroid differentiation regulatory factor 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:197,869,873...197,908,693
Ensembl chr 1:197,870,962...197,908,731
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G
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Efhd1
|
EF-hand domain family, member D1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798
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G
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Esr2
|
estrogen receptor 2
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
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G
|
Fam171a2
|
family with sequence similarity 171, member A2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,893,543...87,904,247
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G
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Fam180a
|
family with sequence similarity 180, member A
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:64,959,999...64,975,176
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G
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Fam210b
|
family with sequence similarity 210, member B
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:181,536,673...181,546,834
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G
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Fam241b
|
family with sequence similarity 241 member B
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,595,084...30,597,844 Ensembl chr 6:30,595,084...30,597,844
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G
|
Fgd6
|
FYVE, RhoGEF and PH domain containing 6
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806
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G
|
Fhl2
|
four and a half LIM domains 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326
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G
|
Galnt15
|
polypeptide N-acetylgalactosaminyltransferase 15
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr16:7,233,524...7,273,290
Ensembl chr16:7,233,606...7,273,285
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G
|
Gng5
|
G protein subunit gamma 5
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:238,054,954...238,063,451
Ensembl chr11:58,096,362...58,096,565 Ensembl chr 2:58,096,362...58,096,565
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G
|
Hipk4
|
homeodomain interacting protein kinase 4
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:91,938,278...91,948,683
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G
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Hmcn1
|
hemicentin 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519
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|
G
|
Hsd3b1
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA
|
CTD |
PMID:28964809 |
|
NCBI chr 2:188,858,574...188,864,694
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|
G
|
Il6r
|
interleukin 6 receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
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G
|
Isg20l2
|
interferon stimulated exonuclease gene 20-like 2
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:175,695,615...175,705,095
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G
|
Kdm5a
|
lysine demethylase 5A
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121
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G
|
Kitlg
|
KIT ligand
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793
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G
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Knstrn
|
kinetochore-localized astrin/SPAG5 binding protein
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418
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G
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Ldlrap1
|
low density lipoprotein receptor adaptor protein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:152,229,505...152,262,290
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G
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Lmod1
|
leiomodin 1
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116
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G
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Lrg1
|
leucine-rich alpha-2-glycoprotein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337
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G
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Lsr
|
lipolysis stimulated lipoprotein receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:95,313,033...95,329,354
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G
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Mrpl33
|
mitochondrial ribosomal protein L33
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987
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G
|
Mtmr11
|
myotubularin related protein 11
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026
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G
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Myof
|
myoferlin
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multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768
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G
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Nr4a1
|
nuclear receptor subfamily 4, group A, member 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
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G
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Nr5a1
|
nuclear receptor subfamily 5, group A, member 1
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]
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CTD |
PMID:28964809 |
|
NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046
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G
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Prkaca
|
protein kinase cAMP-activated catalytic subunit alpha
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494
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G
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Prpf40a
|
pre-mRNA processing factor 40 homolog A
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363
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G
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Pspc1
|
paraspeckle component 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828
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G
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Pth1r
|
parathyroid hormone 1 receptor
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108
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G
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Rassf5
|
Ras association domain family member 5
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277
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G
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Rgs22
|
regulator of G-protein signaling 22
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 7:69,073,681...69,194,041
Ensembl chr 7:69,075,562...69,194,102
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G
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S1pr3
|
sphingosine-1-phosphate receptor 3
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,928,444...13,947,197
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G
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Selplg
|
selectin P ligand
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:48,457,102...48,470,444
Ensembl chr12:48,456,932...48,473,154
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G
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Siglec10
|
sialic acid binding Ig-like lectin 10
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SIGLEC10 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:102,953,894...102,962,964
Ensembl chr 1:102,953,918...102,962,964
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G
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Slc16a1
|
solute carrier family 16 member 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977
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G
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Snx30
|
sorting nexin family member 30
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:79,478,804...79,608,118
Ensembl chr 5:79,478,912...79,607,052
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G
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Ssc5d
|
scavenger receptor cysteine rich family member with 5 domains
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 1:77,920,781...77,939,284
Ensembl chr 1:77,920,783...77,938,574
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G
|
Star
|
steroidogenic acute regulatory protein
|
multiple interactions
|
EXP
|
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein
|
CTD |
PMID:28964809 |
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
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G
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Styxl1
|
serine/threonine/tyrosine interacting-like 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr12:26,544,059...26,576,365
Ensembl chr12:26,544,067...26,576,366
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G
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Sumo1
|
small ubiquitin-like modifier 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890
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G
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Tc2n
|
tandem C2 domains, nuclear
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:126,526,009...126,614,215
|
|
G
|
Tp53i11
|
tumor protein p53 inducible protein 11
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:99,600,159...99,615,432
|
|
G
|
Vcpip1
|
valosin containing protein interacting protein 1
|
multiple interactions
|
ISO
|
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA
|
CTD |
PMID:27424125 |
|
NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778
|
|
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G
|
Acan
|
aggrecan
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]
|
CTD |
PMID:34600870 |
|
NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]
|
CTD |
PMID:34600870 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Col2a1
|
collagen type II alpha 1 chain
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
|
|
G
|
Mmp13
|
matrix metallopeptidase 13
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp3
|
matrix metallopeptidase 3
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]; irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
|
CTD |
PMID:34600870 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions increases activity
|
EXP
|
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [irisflorentin results in increased activity of ACHE protein]
|
CTD |
PMID:31034797 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
|
G
|
Aldh2
|
aldehyde dehydrogenase 2 family member
|
decreases activity
|
EXP
|
prunetin results in decreased activity of ALDH2 protein
|
CTD |
PMID:11142365 |
|
NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
|
CTD |
PMID:23597450 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
|
CTD |
PMID:23597450 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
|
CTD |
PMID:23597450 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions decreases expression
|
ISO
|
[prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
|
CTD |
PMID:23597450 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions decreases expression
|
ISO
|
[prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
|
CTD |
PMID:23597450 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
|
CTD |
PMID:23597450 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
|
G
|
Acadm
|
acyl-CoA dehydrogenase medium chain
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864
|
|
G
|
Acox1
|
acyl-CoA oxidase 1
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
|
|
G
|
Dgat1
|
diacylglycerol O-acyltransferase 1
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016
|
|
G
|
Dgat2
|
diacylglycerol O-acyltransferase 2
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566
|
|
G
|
Dpp4
|
dipeptidylpeptidase 4
|
multiple interactions
|
ISO
|
[Xiao-Ke-An results in increased abundance of tectoridin] which results in decreased activity of DPP4 protein
|
CTD |
PMID:32535096 |
|
NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422
|
|
G
|
Gpam
|
glycerol-3-phosphate acyltransferase, mitochondrial
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in increased expression of GPAM mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
ISO
|
tectoridin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]
|
CTD |
PMID:20637825 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
|
G
|
Abcb11
|
ATP binding cassette subfamily B member 11
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA; [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 protein
|
CTD |
PMID:37348807 |
|
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC2 protein
|
CTD |
PMID:37348807 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
G
|
Abcc4
|
ATP binding cassette subfamily C member 4
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 protein
|
CTD |
PMID:37348807 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased activity of CAT protein
|
CTD |
PMID:37348807 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]
|
CTD |
PMID:35390440 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 protein]
|
CTD |
PMID:35390440 |
|
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
|
|
G
|
Fasn
|
fatty acid synthase
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of FASN protein]
|
CTD |
PMID:35390440 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA]
|
CTD |
PMID:37348807 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLM protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLM mRNA]
|
CTD |
PMID:37348807 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]
|
CTD |
PMID:37348807 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of HMOX1 mRNA]
|
CTD |
PMID:37348807 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NFE2L2 protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NFE2L2 mRNA]
|
CTD |
PMID:37348807 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in increased expression of NFKB1 mRNA]
|
CTD |
PMID:35390440 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO
|
[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 protein
|
CTD |
PMID:37348807 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
|
|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 protein]
|
CTD |
PMID:35390440 PMID:37348807 |
|
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1I3 mRNA]
|
CTD |
PMID:37348807 |
|
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
|
|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of OCLN mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of OCLN protein]
|
CTD |
PMID:35390440 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]
|
CTD |
PMID:35390440 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]
|
CTD |
PMID:35390440 |
|
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of TJP1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of TJP1 protein]
|
CTD |
PMID:35390440 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TLR4 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein]
|
CTD |
PMID:35390440 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
|
CTD |
PMID:35390440 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|