methoxyisoflavone - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	methoxyisoflavone	go back to main search page
Accession:	CHEBI:38756	browse the term
Definition:	Members of the class of isoflavones with at least one methoxy substituent.
Synonyms:	related_synonym:	methoxyisoflavones

show annotations for term's descendants Sort by:
Rat (318 ) Mouse (321 ) Human (326 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (318)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

affects activity

ISO

afromosin affects the activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

biochanin A inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; biochanin A promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

decreases activity

ISO

biochanin A results in decreased activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

acetylcholinesterase

multiple interactions

ISO

[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased activity of ACHE protein; [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]

PMID:33410021 PMID:35547012

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

agrin

decreases expression

ISO

biochanin A results in decreased expression of AGRN mRNA

NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:172,031,528...172,064,539

G

aryl hydrocarbon receptor

multiple interactions
increases activity
affects binding

ISO
EXP

AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]
biochanin A results in increased activity of AHR protein
biochanin A binds to AHR protein

PMID:16903077 PMID:28985473 PMID:31621310

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

ISO

biochanin A results in decreased expression of ALDH7A1 mRNA

NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467

G

AT-rich interaction domain 5B

increases expression

ISO

biochanin A results in increased expression of ARID5B mRNA

NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686

G

BRISC and BRCA1 A complex member 2

increases expression

ISO

biochanin A results in increased expression of BABAM2 mRNA

NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:30,071,611...30,467,341

G

butyrylcholinesterase

multiple interactions

ISO

[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression

ISO

biochanin A results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

biochanin A results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

increases activity
multiple interactions

ISO

biochanin A results in increased activity of CASP3 protein
biochanin A inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]

PMID:12791511 PMID:38648921

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

ISO

biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cadherin 2

decreases expression

ISO

biochanin A results in decreased expression of CDH2 mRNA

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

biochanin A results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

creatine kinase B

increases activity

ISO

biochanin A results in increased activity of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

claudin 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein]

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases expression
decreases activity

ISO

[Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein
biochanin A results in decreased expression of CYP19A1 mRNA
biochanin A results in decreased activity of CYP19A1 protein

PMID:9435150 PMID:16965912

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases hydroxylation
decreases methylation
increases expression
increases activity

ISO

AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased hydroxylation of biochanin A
CYP1A1 protein results in decreased methylation of biochanin A
biochanin A results in increased activity of CYP1A1 protein

PMID:15479032 PMID:16903077 PMID:28985473 PMID:31621310

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases metabolic processing
decreases activity

ISO
EXP

CYP1A2 protein results in increased metabolism of biochanin A
biochanin A results in decreased activity of CYP1A2 protein

PMID:12814970 PMID:26278343

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases methylation
multiple interactions
increases expression

ISO

CYP1B1 protein results in decreased methylation of biochanin A
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]

PMID:15479032 PMID:28985473 PMID:31621310

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 27, subfamily b, polypeptide 1

affects activity
increases activity
increases expression
affects expression

ISO

biochanin A affects the activity of CYP27B1 protein
biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein
biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA
biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA

PMID:15795327 PMID:17659868

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

deoxyribose-phosphate aldolase

decreases expression

ISO

biochanin A results in decreased expression of DERA mRNA

NCBI chr 4:172,394,971...172,473,746
Ensembl chr 4:172,394,962...172,490,142

G

eukaryotic translation initiation factor 5

decreases expression

ISO

biochanin A results in decreased expression of EIF5 mRNA

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

decreases expression

ISO

biochanin A results in decreased expression of ENPP5 mRNA

NCBI chr 9:24,407,574...24,415,029
Ensembl chr 9:24,408,218...24,414,867

G

epidermal growth factor receptor pathway substrate 15

decreases expression

ISO

biochanin A results in decreased expression of EPS15 mRNA

NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856

G

estrogen receptor 1

multiple interactions
decreases expression
affects binding

ISO
EXP

biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]
biochanin A results in decreased expression of ESR1 protein
[Fulvestrant co-treated with biochanin A] results in decreased expression of ESR1 protein; [Fulvestrant co-treated with biochanin A] results in increased expression of ESR1 mRNA
biochanin A binds to ESR1 protein

PMID:9751507 PMID:12598185 PMID:14579009 PMID:16076101 PMID:19913605 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression
decreases expression
affects binding

ISO
EXP

biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]
[Fulvestrant co-treated with biochanin A] results in increased expression of ESR2 mRNA; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of ESR2 protein]
biochanin A results in increased expression of ESR2 mRNA
biochanin A binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16076101 PMID:16566672 PMID:19913605 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

estrogen related receptor, alpha

multiple interactions
affects binding

ISO

biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]
biochanin A binds to ESRRA protein mutant form

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

estrogen-related receptor beta

multiple interactions

ISO

biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]

NCBI chr 6:111,738,662...111,894,087
Ensembl chr 6:111,738,662...111,894,087

G

estrogen-related receptor gamma

multiple interactions

ISO

biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]

NCBI chr13:101,699,043...102,316,877
Ensembl chr13:101,889,706...102,316,877

G

fibrillarin

increases expression

ISO

biochanin A results in increased expression of FBL mRNA

NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:92,597,258...92,606,506

G

folate receptor alpha

decreases expression

ISO

biochanin A results in decreased expression of FOLR1 mRNA

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669

G

glucose-6-phosphate dehydrogenase

affects binding
decreases activity
decreases expression

ISO

biochanin A binds to G6PD protein
biochanin A results in decreased activity of G6PD protein
biochanin A results in decreased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

ganglioside GM2 activator

decreases expression

ISO

biochanin A results in decreased expression of GM2A mRNA

NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451

G

G protein subunit alpha i3

decreases expression

ISO

biochanin A results in decreased expression of GNAI3 mRNA

NCBI chr 2:198,430,920...198,468,874

G

glutathione peroxidase 1

decreases expression

ISO

biochanin A results in decreased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

intercellular adhesion molecule 1

multiple interactions

ISO

biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

insulin-like growth factor 1

multiple interactions

EXP

[Fulvestrant co-treated with biochanin A] results in decreased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 10

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 17A

multiple interactions

ISO

biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 18

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

PMID:38648921 PMID:38764152

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

increases expression

ISO

biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

ISO

biochanin A inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein]

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267

G

low density lipoprotein receptor class A domain containing 4

decreases expression

ISO

biochanin A results in decreased expression of LDLRAD4 mRNA

NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064

G

latexin

increases expression

ISO

biochanin A results in increased expression of LXN mRNA

NCBI chr 2:154,037,604...154,043,473
Ensembl chr 2:154,037,292...154,043,488

G

mitogen activated protein kinase 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

marker of proliferation Ki-67

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MKI67 protein]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 14

decreases expression

ISO

biochanin A results in decreased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

decreases activity
decreases expression

ISO

biochanin A results in decreased activity of MMP2 protein
biochanin A results in decreased expression of MMP2 mRNA

PMID:16598420 PMID:38266663

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases activity
decreases expression

ISO

biochanin A results in decreased activity of MMP9 protein
biochanin A results in decreased expression of MMP9 mRNA

PMID:16598420 PMID:38266663

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]

PMID:38648921 PMID:38764152

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallothionein 2

increases expression

ISO

biochanin A results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MUC2 protein]

NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280

G

nuclear receptor coactivator 1

multiple interactions

ISO

biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

NADH:ubiquinone oxidoreductase subunit A5

decreases expression

ISO

biochanin A results in decreased expression of NDUFA5 mRNA

NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein]
biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]

PMID:22387535 PMID:38764152

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

non-POU domain containing, octamer-binding

decreases expression

ISO

biochanin A results in decreased expression of NONO mRNA

NCBI chr X:70,594,116...70,611,976
Ensembl chr X:70,593,888...70,611,979

G

nitric oxide synthase 2

multiple interactions

ISO

biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

biochanin A binds to and results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

occludin

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

purinergic receptor P2Y14

decreases expression
multiple interactions

EXP

biochanin A results in decreased expression of P2RY14 mRNA
Fulvestrant inhibits the reaction [biochanin A results in decreased expression of P2RY14 mRNA]

NCBI chr 2:145,522,598...145,563,074
Ensembl chr 2:145,516,390...145,564,788

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

biochanin A results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prefoldin subunit 5

decreases expression

ISO

biochanin A results in decreased expression of PFDN5 mRNA

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

progesterone receptor

affects binding
multiple interactions
increases expression

ISO
EXP

biochanin A binds to PGR protein
Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA]
biochanin A inhibits the reaction [Progesterone binds to PGR protein]

PMID:14579009 PMID:16076101 PMID:34848279

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

plasminogen activator, urokinase receptor

decreases expression

ISO

biochanin A results in decreased expression of PLAUR protein

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

proline-rich nuclear receptor coactivator 1

multiple interactions

ISO

biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]

NCBI chr 5:52,443,400...52,489,303
Ensembl chr 5:52,443,400...52,446,491

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

biochanin A binds to and results in increased activity of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein]
biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

PMID:22387535 PMID:38764152

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAB, member RAS oncogene family-like 6

decreases expression

ISO

biochanin A results in decreased expression of RABL6 mRNA

NCBI chr 3:28,800,802...28,826,722
Ensembl chr 3:28,800,802...28,826,722

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions

ISO

biochanin A results in decreased expression of RELA mRNA
biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]

PMID:12111696 PMID:38764152

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

replication timing regulatory factor 1

decreases expression

ISO

biochanin A results in decreased expression of RIF1 mRNA

NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:56,963,854...57,017,106

G

RAR-related orphan receptor C

multiple interactions

ISO

biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

RNA pseudouridine synthase D3

decreases expression

ISO

biochanin A results in decreased expression of RPUSD3 mRNA

NCBI chr 4:148,108,857...148,118,246
Ensembl chr 4:148,109,383...148,118,206

G

SH3 domain containing GRB2 like 1, endophilin A2

increases expression

ISO

biochanin A results in increased expression of SH3GL1 mRNA

NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890

G

solute carrier family 16 member 1

multiple interactions

EXP

[biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 25 member 3

decreases expression

ISO

biochanin A results in decreased expression of SLC25A3 mRNA

NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:27,499,165...27,506,309

G

solute carrier organic anion transporter family, member 1c1

decreases activity
multiple interactions

EXP

biochanin A results in decreased activity of SLCO1B1 protein
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate

NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395

G

sequestosome 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

serine and arginine rich splicing factor 1

decreases expression

ISO

biochanin A results in decreased expression of SRSF1 mRNA

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:73,336,422...73,342,548

G

sulfotransferase family 1A member 1

increases expression

EXP

biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1E member 1

increases expression

EXP

biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

sulfotransferase family 2A member 1

increases expression

EXP

biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein

NCBI chr 1:84,582,011...84,639,001

G

sushi domain containing 6

increases expression

ISO

biochanin A results in increased expression of SUSD6 mRNA

NCBI chr 6:106,130,183...106,262,900
Ensembl chr 6:106,169,118...106,262,900

G

spleen associated tyrosine kinase

multiple interactions

ISO

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein]

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278

G

thyroid hormone receptor beta

multiple interactions

ISO

biochanin A binds to and results in increased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tight junction protein 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

multiple interactions

EXP
ISO

biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; biochanin A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

PMID:16735947 PMID:38648921 PMID:38764152

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 21

decreases expression

ISO

biochanin A results in decreased expression of TNFRSF21 mRNA

NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:25,376,400...25,451,323

G

tubulin, beta 5 class I

increases expression

ISO

biochanin A results in increased expression of TUBB mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

tyrosinase

increases expression

ISO

biochanin A results in increased expression of TYR mRNA

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin-conjugating enzyme E2D 2

decreases expression

ISO

biochanin A results in decreased expression of UBE2D2 mRNA

NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,638,527...27,683,074

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

ISO

UGT1A1 protein results in increased glucuronidation of biochanin A
biochanin A results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:31621310

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of biochanin A

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-51 like autophagy activating kinase 1

multiple interactions

ISO

biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

EXP

biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein]

PMID:16223672 PMID:16735947

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

WD repeat domain 74

decreases expression

ISO

biochanin A results in decreased expression of WDR74 mRNA

NCBI chr 1:215,060,901...215,065,687
Ensembl chr 1:215,060,961...215,066,336

G

WW and C2 domain containing 2

decreases expression

ISO

biochanin A results in decreased expression of WWC2 mRNA

NCBI chr16:50,991,096...51,154,529
Ensembl chr16:50,991,096...51,154,526

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 14b

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ABHD14B protein

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

acetylcholinesterase

increases expression
multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ACHE mRNA
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in increased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

amyloid beta precursor protein

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

ATP synthase F1 subunit alpha

increases expression
multiple interactions

EXP
ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ATP5F1A mRNA
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

beta-secretase 1

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of BACE1 protein]

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

biliverdin reductase B

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of BLVRB protein

NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:91,866,258...91,884,225

G

caspase 3

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cyclin B1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D3

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin G1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin-dependent kinase 7

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1C

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

cyclin dependent kinase inhibitor 2D

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN2D mRNA

NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:28,108,044...28,110,809

G

erythropoietin

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

endoplasmic reticulum protein 29

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ERP29 protein

NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased degradation of and results in increased expression of HIF1A protein modified form; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in decreased degradation of HIF1A protein
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A mRNA; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

high mobility group box 1

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

interleukin 1 beta

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA]

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 33

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein]

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901

G

interleukin 6

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

keratin 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of KRT1 protein

NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537

G

LIM and SH3 protein 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of LASP1 protein

NCBI chr10:83,290,820...83,331,989
Ensembl chr10:83,290,865...83,331,988

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microtubule-associated protein tau

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased phosphorylation of MAPT protein]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

minichromosome maintenance complex component 5

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758

G

minichromosome maintenance complex component 6

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

NADH:ubiquinone oxidoreductase subunit B8

multiple interactions

EXP
ISO

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936

G

NFE2 like bZIP transcription factor 2

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of NME1 protein

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

nuclear respiratory factor 1

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NRF1 protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]]

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

phosphatidylethanolamine binding protein 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

phosphoglycerate mutase 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PGAM1 protein

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203

G

pyridoxamine 5'-phosphate oxidase

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PNPO protein

NCBI chr10:82,421,027...82,427,288
Ensembl chr10:82,421,027...82,427,288

G

PPARG coactivator 1 alpha

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of PPARGC1A protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of and affects the localization of PPARGC1A protein]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of PPARGC1A protein]]

PMID:36195188 PMID:36436616

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

peroxiredoxin 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of PRDX2 protein

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proline rich membrane anchor 1

increases expression

EXP

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRIMA1 mRNA

NCBI chr 6:128,094,686...128,155,592
Ensembl chr 6:128,103,175...128,154,865

G

prostaglandin reductase 1

increases expression

ISO

[Calycosin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells

RGD

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

RAD9 checkpoint clamp component A

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of RAD9A mRNA

NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:210,917,970...210,925,161

G

ring-box 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

ISO
EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667

G

sirtuin 1

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

S-phase kinase-associated protein 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of SKP1 mRNA

NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308

G

S-phase kinase associated protein 2

decreases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of SKP2 mRNA

NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438

G

stress-induced phosphoprotein 1

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

transgelin 2

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330

G

transcription factor A, mitochondrial

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of TFAM protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM protein]

PMID:36195188 PMID:36436616

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin I3, cardiac type

multiple interactions

ISO

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

ubiquitin protein ligase E3A

increases expression

ISO

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UBE3A mRNA

NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

ISO

UGT1A3 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

ISO

UGT2B7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions
increases expression

ISO
EXP

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UQCRC2 mRNA

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

calycosin-7-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]
calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]
calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases cleavage
multiple interactions
increases expression

ISO

calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases expression

ISO

calycosin-7-O-beta-D-glucoside results in decreased expression of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

erythropoietin

increases expression

ISO

calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

glutamic--pyruvic transaminase

decreases expression

ISO

calycosin-7-O-beta-D-glucoside results in decreased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

calycosin-7-O-beta-D-glucoside results in decreased degradation of and results in increased expression of HIF1A protein modified form; calycosin-7-O-beta-D-glucoside results in increased expression of and results in decreased degradation of HIF1A protein
calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

thioredoxin 1

multiple interactions
decreases expression

ISO

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]
calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein
calycosin-7-O-beta-D-glucoside results in decreased expression of TXN mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity
increases expression
affects activity

ISO

Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
formononetin results in decreased activity of ABCB1 protein
formononetin affects the activity of ABCB1 protein

PMID:15796199 PMID:23867903 PMID:27996361 PMID:34217736

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

affects activity
decreases expression
multiple interactions

ISO

formononetin affects the activity of ABCC1 protein
formononetin results in decreased expression of ABCC1 mRNA
Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]

PMID:15796199 PMID:23867903

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]

PMID:23867903 PMID:28414026

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 4

multiple interactions

EXP

formononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

acid phosphatase 5, tartrate resistant

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased activity of ACP5 protein]; formononetin inhibits the reaction [Streptozocin results in increased expression of ACP5 mRNA]

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

aryl hydrocarbon receptor

multiple interactions
increases activity

ISO

fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member B10

increases expression

ISO

formononetin results in increased expression of AKR1B10 mRNA

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]
formononetin decreases phosphorylation of AKT1 protein in lung

CTD
RGD

PMID:34077701 PMID:32276600

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
formononetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

PMID:23867903 PMID:28414026

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

formononetin results in decreased expression of BCL2 mRNA
formononetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
formononetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]

PMID:23867903 PMID:28414026 PMID:34077701

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

baculoviral IAP repeat-containing 2

multiple interactions

ISO

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of BIRC2 protein]

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

caspase 3

multiple interactions
increases activity
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
formononetin increases activity of CASP3 protein in lung
formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]

CTD
RGD

PMID:23867903 PMID:28414026 PMID:34077701 PMID:32276600

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions

ISO

formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions
increases expression
increases activity

ISO

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases expression
increases activity

ISO

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]

Ensembl chr 5:159,391,188...159,409,648

G

cyclin B1

increases expression
multiple interactions

ISO
EXP

formononetin results in increased expression of CCNB1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCNB1 protein]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

increases expression
multiple interactions

EXP
ISO

formononetin results in increased expression of CCND1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCND1 protein]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

carnitine palmitoyltransferase 1A

increases expression

ISO

formononetin results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

cathepsin K

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK protein]

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases hydroxylation
increases expression
multiple interactions
decreases methylation

ISO

CYP1A1 protein results in increased hydroxylation of formononetin
formononetin results in increased expression of CYP1A1 mRNA
fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in decreased methylation of formononetin

PMID:15479032 PMID:28985473 PMID:37793997

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO
EXP

formononetin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases methylation
increases expression

ISO

CYP1B1 protein results in decreased methylation of formononetin
formononetin results in increased expression of CYP1B1 mRNA

PMID:15479032 PMID:28985473

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

ISO

formononetin results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

epidermal growth factor receptor

decreases phosphorylation

ISO

formononetin decreases phosphorylation of EGFR protein in lung

RGD

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

erythropoietin

increases expression

ISO

formononetin results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

estrogen receptor 1

affects binding
multiple interactions

ISO

formononetin binds to ESR1 protein
[Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein
formononetin binds to and results in increased activity of ESR1 protein

PMID:9751507 PMID:16076101 PMID:16773531 PMID:37269934

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
affects binding

ISO

formononetin binds to and results in increased activity of ESR2 protein
formononetin binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16076101 PMID:16773531 PMID:19913605

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased expression of FOS mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of GCLM protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

formononetin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

ISO

formononetin results in increased expression of HIF1A mRNA; formononetin results in increased expression of HIF1A protein
formononetin results in decreased degradation of and results in increased expression of HIF1A protein modified form; formononetin results in increased expression of and results in decreased degradation of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

multiple interactions

ISO
EXP

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]
formononetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]

PMID:34077701 PMID:37944786

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 17A

multiple interactions

ISO

formononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 1 beta

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

increases expression

ISO

formononetin results in increased expression of IL4 mRNA; formononetin results in increased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:37269934 PMID:39855309

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased expression of JUN mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

mitogen activated protein kinase 1

multiple interactions

ISO

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:34077701 PMID:39855309

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 11

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK11 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK11 protein]

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen-activated protein kinase 12

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK12 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK12 protein]

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 13

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK13 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK13 protein]

NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191

G

mitogen activated protein kinase 14

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK14 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions

ISO

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

PMID:34077701 PMID:39855309

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
formononetin inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK8 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

PMID:34077701 PMID:39855309

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

matrilin 3

decreases expression

ISO

formononetin results in decreased expression of MATN3 mRNA

NCBI chr 6:37,467,729...37,487,776
Ensembl chr 6:37,467,729...37,487,776

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

formononetin decreases expression of MCL1 protein in lung

RGD

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

MDM2 proto-oncogene

increases expression

EXP

formononetin results in increased expression of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

increases expression

EXP

formononetin results in increased expression of MDM4 protein

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

matrix metallopeptidase 9

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 protein]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]
formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]

PMID:34077701 PMID:37269934

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

formononetin inhibits the reaction [CXCL8 protein results in increased phosphorylation of NFKBIA protein]
formononetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

PMID:22387535 PMID:39855309

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nerve growth factor

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of NGF mRNA]; formononetin inhibits the reaction [Glucose results in decreased secretion of and results in decreased expression of NGF protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]

PMID:37269934 PMID:39855309

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions

ISO

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression
multiple interactions

EXP

formononetin results in increased expression of NOS3 mRNA
formononetin results in increased phosphorylation of and results in increased activity of NOS3 protein

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

progastricsin

decreases expression

ISO

formononetin results in decreased expression of PGC mRNA

NCBI chr 9:20,755,002...20,763,220
Ensembl chr 9:20,755,002...20,763,220

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in decreased localization of PPARG protein]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased localization of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation
multiple interactions

ISO

formononetin results in increased phosphorylation of PRKAA1 protein
Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions
increases phosphorylation

ISO

Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA2 protein]

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions

ISO

[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of PRKACB protein

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

prostaglandin reductase 1

increases expression

ISO

[Formononetin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells

RGD

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:37269934 PMID:39855309

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased localization of RELA protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of RELA protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sirtuin 1

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 3

affects binding
multiple interactions

EXP

formononetin binds to SIRT3 protein
formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

solute carrier family 22 member 2

decreases expression

EXP

formononetin results in decreased expression of SLC22A2 mRNA

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 6 member 14

decreases expression

ISO

formononetin results in decreased expression of SLC6A14 mRNA

NCBI chr X:117,109,063...117,169,522
Ensembl chr X:117,108,947...117,169,828

G

superoxide dismutase 1

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP
ISO

formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
formononetin inhibits the reaction [Dextran Sulfate results in decreased expression of SOD2 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 protein]

PMID:37944786 PMID:39855309

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

serine/threonine kinase 11

multiple interactions

ISO

[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965

G

transgelin

decreases expression

ISO

formononetin results in decreased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

transcription factor A, mitochondrial

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of TFAM mRNA]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transcription factor B2, mitochondrial

multiple interactions

EXP

formononetin inhibits the reaction [Glucose results in decreased expression of TFB2M mRNA]

NCBI chr13:93,810,859...93,828,678
Ensembl chr13:93,810,731...93,828,594

G

toll-like receptor 4

multiple interactions

ISO

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

formononetin inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of TNF protein]; formononetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
decreases expression

EXP
ISO

formononetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
formononetin results in decreased expression of TP53 protein
XI-006 inhibits the reaction [formononetin results in decreased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

transient receptor potential cation channel, subfamily V, member 5

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV5 mRNA]

NCBI chr 4:71,503,085...71,531,134
Ensembl chr 4:71,503,093...71,529,384

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions

ISO

formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA]

NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:71,474,007...71,489,671

G

thioredoxin interacting protein

increases expression

ISO

formononetin results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

multiple interactions

ISO

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

ISO

UGT1A1 protein results in increased glucuronidation of formononetin
formononetin results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:37793997

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of formononetin

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

glycitein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acyl-CoA synthetase long-chain family member 3

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097

G

adducin 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA

NCBI chr 4:120,001,977...120,101,090
Ensembl chr 4:120,002,054...120,101,091

G

aryl hydrocarbon receptor

increases activity

ISO

glycitein results in increased activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldehyde dehydrogenase 1 family, member A2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA

NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883

G

alanyl aminopeptidase, membrane

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA

NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101

G

Rho GDP dissociation inhibitor alpha

decreases expression

ISO

glycitein results in decreased expression of ARHGDIA mRNA

NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347

G

atonal bHLH transcription factor 8

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA

NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379

G

ATPase H+ transporting V0 subunit a2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ATP6V0A2 mRNA

NCBI chr12:37,608,211...37,640,860
Ensembl chr12:37,472,813...37,640,860

G

bromodomain adjacent to zinc finger domain, 1A

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA

NCBI chr 6:78,124,872...78,247,672
Ensembl chr 6:78,124,872...78,247,648

G

branched chain ketoacid dehydrogenase kinase

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA

NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453

G

bisphosphoglycerate mutase

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627

G

calcium binding protein 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA

NCBI chr 1:83,486,396...83,499,421
Ensembl chr 1:83,486,396...83,499,421

G

calcyclin binding protein

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505

G

caspase 8 associated protein 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA

NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632

G

cyclin A2

decreases expression

ISO

glycitein results in decreased expression of CCNA2

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin D1

increases expression

ISO

glycitein results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

CD200 receptor 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA

NCBI chr11:69,392,943...69,427,213
Ensembl chr11:69,392,975...69,427,128

G

cyclin-dependent kinase 4

decreases activity

ISO

glycitein results in decreased activity of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

ESR2 affects the reaction [glycitein results in increased expression of CDKN1A]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cilia and flagella associated protein 251

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA

NCBI chr12:38,923,154...38,997,881
Ensembl chr12:38,922,330...38,954,783

G

cytochrome b reductase 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA

NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

DENN domain containing 2D

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA

NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397

G

DNA methyltransferase 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dedicator of cyto-kinesis 3

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA

NCBI chr 8:116,431,158...116,782,218
Ensembl chr 8:116,431,159...116,782,195

G

dipeptidyl peptidase 9

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA

NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715

G

erythroid differentiation regulatory factor 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA

NCBI chr 1:197,869,873...197,908,693
Ensembl chr 1:197,870,962...197,908,731

G

EF-hand domain family, member D1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA

NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798

G

Eph receptor A1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

espin

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ESPN mRNA

NCBI chr 5:167,909,271...167,943,168
Ensembl chr 5:167,909,271...167,942,984

G

estrogen receptor 1

multiple interactions
affects binding

ISO

glycitein inhibits the reaction [Estradiol binds to ESR1 protein]
glycitein binds to ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
affects response to substance

ISO
EXP

ESR2 affects the reaction [glycitein results in increased expression of CDKN1A]
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA
ESR2 affects the susceptibility to glycitein

PMID:21161820 PMID:28964809

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

family with sequence similarity 171, member A2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA

NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,893,543...87,904,247

G

family with sequence similarity 180, member A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA

NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:64,959,999...64,975,176

G

family with sequence similarity 210, member B

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA

NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:181,536,673...181,546,834

G

family with sequence similarity 241 member B

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA

NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,595,084...30,597,844
Ensembl chr 6:30,595,084...30,597,844

G

FYVE, RhoGEF and PH domain containing 6

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA

NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806

G

four and a half LIM domains 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

formin 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA

NCBI chr13:88,986,863...89,303,789
Ensembl chr13:88,986,842...89,303,789

G

polypeptide N-acetylgalactosaminyltransferase 15

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA

NCBI chr16:7,233,524...7,273,290
Ensembl chr16:7,233,606...7,273,285

G

G protein subunit gamma 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA

NCBI chr 2:238,054,954...238,063,451
Ensembl chr11:58,096,362...58,096,565
Ensembl chr 2:58,096,362...58,096,565

G

homeodomain interacting protein kinase 4

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA

NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:91,938,278...91,948,683

G

hemicentin 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA

NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA

NCBI chr 2:188,858,574...188,864,694

G

interferon-related developmental regulator 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IFRD2 mRNA

NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:117,139,550...117,144,836

G

interleukin 6 receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interferon regulatory factor 2 binding protein 1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IRF2BP1 mRNA

NCBI chr 1:87,780,782...87,783,483
Ensembl chr 1:87,779,406...87,785,661

G

interferon stimulated exonuclease gene 20-like 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA

NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:175,695,615...175,705,095

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases activity

ISO

glycitein results in increased activity of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel modifier subfamily G member 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA

NCBI chr18:76,017,225...76,085,377
Ensembl chr18:76,018,047...76,083,688

G

lysine demethylase 5A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA

NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121

G

KIT ligand

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

kinetochore-localized astrin/SPAG5 binding protein

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418

G

low density lipoprotein receptor adaptor protein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA

NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:152,229,505...152,262,290

G

leiomodin 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA

NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116

G

leucine-rich alpha-2-glycoprotein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA

NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337

G

lipolysis stimulated lipoprotein receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA

NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:95,313,033...95,329,354

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
glycitein results in increased phosphorylation of MAPK1 protein

PMID:17088408 PMID:20188714

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
glycitein results in increased phosphorylation of MAPK3 protein

PMID:17088408 PMID:20188714

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

matrix metallopeptidase 3

decreases expression

ISO

glycitein results in decreased expression of MMP3 mRNA; glycitein results in decreased expression of MMP3 protein

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ISO

glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]
glycitein results in decreased expression of MMP9 mRNA; glycitein results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mitochondrial ribosomal protein L33

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA

NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987

G

myotubularin related protein 11

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA

NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026

G

myoferlin

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA

NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768

G

nitric oxide synthase 2

multiple interactions
decreases activity

ISO

glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
glycitein results in decreased activity of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 5, group A, member 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

nuclear receptor interacting protein 1

increases expression

ISO

glycitein results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

olfactomedin-like 3

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of OLFML3 mRNA

NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:193,932,665...193,935,494

G

proliferating cell nuclear antigen

decreases expression

ISO

glycitein results in decreased expression of PCNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

PDZ and LIM domain 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNA

NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958

G

pinin, desmosome associated protein

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PNN mRNA

NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933

G

POU class 4 homeobox 2

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA

NCBI chr19:46,390,958...46,394,599
Ensembl chr19:46,390,958...46,394,599

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

pre-mRNA processing factor 40 homolog A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA

NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363

G

paraspeckle component 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA

NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828

G

parathyroid hormone 1 receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA

NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108

G

Ras association domain family member 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

regulator of G-protein signaling 22

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA

NCBI chr 7:69,073,681...69,194,041
Ensembl chr 7:69,075,562...69,194,102

G

ribosomal protein S6 kinase A3

increases expression

ISO

glycitein results in increased expression of RPS6KA3 mRNA

NCBI chr X:39,325,926...39,432,017
Ensembl chr X:39,325,926...39,433,678

G

sphingosine-1-phosphate receptor 3

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA

NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,928,444...13,947,197

G

selectin P ligand

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA

NCBI chr12:48,457,102...48,470,444
Ensembl chr12:48,456,932...48,473,154

G

sphingosine-1-phosphate phosphatase 1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA

NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259

G

sialic acid binding Ig-like lectin 10

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SIGLEC10 mRNA

NCBI chr 1:102,953,894...102,962,964
Ensembl chr 1:102,953,918...102,962,964

G

solute carrier family 12 member 2

decreases expression

ISO

glycitein results in decreased expression of SLC12A2 mRNA

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 16 member 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 22 member 8

increases uptake

ISO

SLC22A8 protein results in increased uptake of glycitein analog

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

sorting nexin family member 30

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA

NCBI chr 5:79,478,804...79,608,118
Ensembl chr 5:79,478,912...79,607,052

G

Sp1 transcription factor

multiple interactions
increases activity

ISO

glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

scavenger receptor cysteine rich family member with 5 domains

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA

NCBI chr 1:77,920,781...77,939,284
Ensembl chr 1:77,920,783...77,938,574

G

steroidogenic acute regulatory protein

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stanniocalcin 1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA

NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082

G

serine/threonine/tyrosine interacting-like 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA

NCBI chr12:26,544,059...26,576,365
Ensembl chr12:26,544,067...26,576,366

G

small ubiquitin-like modifier 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA

NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890

G

tachykinin receptor 3

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA

NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:225,940,444...226,037,756

G

tandem C2 domains, nuclear

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA

NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:126,526,009...126,614,215

G

TNF alpha induced protein 6

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

tumor protein p53

increases expression

ISO

glycitein results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible protein 11

decreases expression
multiple interactions

ISO

glycitein results in decreased expression of TP53I11 mRNA
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA

PMID:15757668 PMID:27424125

NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:99,600,159...99,615,432

G

ubiquitin C-terminal hydrolase L1

multiple interactions

ISO

[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

valosin containing protein interacting protein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA

NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778

G

vitamin D receptor

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [glycitein results in increased expression of VDR protein]; glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased expression of VDR protein]
glycitein results in increased expression of VDR mRNA; glycitein results in increased expression of VDR protein

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA synthetase long-chain family member 3

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097

G

aldehyde dehydrogenase 1 family, member A2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA

NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883

G

alanyl aminopeptidase, membrane

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA

NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101

G

amyloid beta precursor protein

multiple interactions

EXP

glycitin inhibits the reaction [APP protein binds to APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

atonal bHLH transcription factor 8

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA

NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379

G

branched chain ketoacid dehydrogenase kinase

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA

NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453

G

bisphosphoglycerate mutase

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627

G

calcium binding protein 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA

NCBI chr 1:83,486,396...83,499,421
Ensembl chr 1:83,486,396...83,499,421

G

calcyclin binding protein

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505

G

caspase 8 associated protein 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA

NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632

G

CD200 receptor 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA

NCBI chr11:69,392,943...69,427,213
Ensembl chr11:69,392,975...69,427,128

G

cilia and flagella associated protein 251

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA

NCBI chr12:38,923,154...38,997,881
Ensembl chr12:38,922,330...38,954,783

G

cytochrome b reductase 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA

NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

DENN domain containing 2D

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA

NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397

G

DNA methyltransferase 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dipeptidyl peptidase 9

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA

NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715

G

erythroid differentiation regulatory factor 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA

NCBI chr 1:197,869,873...197,908,693
Ensembl chr 1:197,870,962...197,908,731

G

EF-hand domain family, member D1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA

NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798

G

estrogen receptor 2

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

family with sequence similarity 171, member A2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA

NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,893,543...87,904,247

G

family with sequence similarity 180, member A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA

NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:64,959,999...64,975,176

G

family with sequence similarity 210, member B

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA

NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:181,536,673...181,546,834

G

family with sequence similarity 241 member B

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA

NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,595,084...30,597,844
Ensembl chr 6:30,595,084...30,597,844

G

FYVE, RhoGEF and PH domain containing 6

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA

NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806

G

four and a half LIM domains 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

polypeptide N-acetylgalactosaminyltransferase 15

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA

NCBI chr16:7,233,524...7,273,290
Ensembl chr16:7,233,606...7,273,285

G

G protein subunit gamma 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA

NCBI chr 2:238,054,954...238,063,451
Ensembl chr11:58,096,362...58,096,565
Ensembl chr 2:58,096,362...58,096,565

G

homeodomain interacting protein kinase 4

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA

NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:91,938,278...91,948,683

G

hemicentin 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA

NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA

NCBI chr 2:188,858,574...188,864,694

G

interleukin 6 receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interferon stimulated exonuclease gene 20-like 2

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA

NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:175,695,615...175,705,095

G

lysine demethylase 5A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA

NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121

G

KIT ligand

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

kinetochore-localized astrin/SPAG5 binding protein

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418

G

low density lipoprotein receptor adaptor protein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA

NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:152,229,505...152,262,290

G

leiomodin 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA

NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116

G

leucine-rich alpha-2-glycoprotein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA

NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337

G

lipolysis stimulated lipoprotein receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA

NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:95,313,033...95,329,354

G

mitochondrial ribosomal protein L33

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA

NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987

G

myotubularin related protein 11

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA

NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026

G

myoferlin

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA

NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 5, group A, member 1

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

pre-mRNA processing factor 40 homolog A

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA

NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363

G

paraspeckle component 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA

NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828

G

parathyroid hormone 1 receptor

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA

NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108

G

Ras association domain family member 5

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

regulator of G-protein signaling 22

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA

NCBI chr 7:69,073,681...69,194,041
Ensembl chr 7:69,075,562...69,194,102

G

sphingosine-1-phosphate receptor 3

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA

NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,928,444...13,947,197

G

selectin P ligand

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA

NCBI chr12:48,457,102...48,470,444
Ensembl chr12:48,456,932...48,473,154

G

sialic acid binding Ig-like lectin 10

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SIGLEC10 mRNA

NCBI chr 1:102,953,894...102,962,964
Ensembl chr 1:102,953,918...102,962,964

G

solute carrier family 16 member 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

sorting nexin family member 30

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA

NCBI chr 5:79,478,804...79,608,118
Ensembl chr 5:79,478,912...79,607,052

G

scavenger receptor cysteine rich family member with 5 domains

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA

NCBI chr 1:77,920,781...77,939,284
Ensembl chr 1:77,920,783...77,938,574

G

steroidogenic acute regulatory protein

multiple interactions

EXP

[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

serine/threonine/tyrosine interacting-like 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA

NCBI chr12:26,544,059...26,576,365
Ensembl chr12:26,544,067...26,576,366

G

small ubiquitin-like modifier 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA

NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890

G

tandem C2 domains, nuclear

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA

NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:126,526,009...126,614,215

G

tumor protein p53 inducible protein 11

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA

NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:99,600,159...99,615,432

G

valosin containing protein interacting protein 1

multiple interactions

ISO

[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA

NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aggrecan

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]

NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779

G

caspase 3

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

collagen type II alpha 1 chain

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

matrix metallopeptidase 13

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

tumor necrosis factor

multiple interactions

ISO

irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]; irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases activity

EXP

4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [irisflorentin results in increased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 2 family member

decreases activity

EXP

prunetin results in decreased activity of ALDH2 protein

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

interleukin 1 beta

multiple interactions

ISO

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NFKB inhibitor alpha

multiple interactions

ISO

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO

[prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

ISO

[prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

tumor necrosis factor

multiple interactions

ISO

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase medium chain

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA]

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA oxidase 1

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

diacylglycerol O-acyltransferase 1

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA]

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

diacylglycerol O-acyltransferase 2

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566

G

dipeptidylpeptidase 4

multiple interactions

ISO

[Xiao-Ke-An results in increased abundance of tectoridin] which results in decreased activity of DPP4 protein

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in increased expression of GPAM mRNA]

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

tectoridin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA; [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

catalase

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 protein]

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

fatty acid synthase

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of FASN protein]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLM protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

multiple interactions

ISO

tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

heme oxygenase 1

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NFE2L2 protein; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NFE2L2 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in increased expression of NFKB1 mRNA]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 protein]

PMID:35390440 PMID:37348807

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1I3 mRNA]

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

occludin

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of OCLN mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

tight junction protein 1

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of TJP1 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

toll-like receptor 4

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TLR4 mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; tectorigenin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
atom	20860
nonmetal atom	20766
oxygen atom	20457
oxygen molecular entity	20457
organooxygen compound	19806
ether	17649
methoxyisoflavone	318
2',5-Dihydroxy-4',7-dimethoxyisoflavone	0
2',7-Dihydroxy-4',5'-dimethoxyisoflavone	0
2'-Hydroxypiscerythrinetin	0
2'-Methoxyformonetin	0
2'-hydroxy-3'-methoxygenistein	0
2'-hydroxybiochanin A	0
3',4'-Dimethoxy-6,7-methylenedioxyisoflavone	0
3'-O-methylorobol	0
3'-methoxyisoflavones	0
3-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-8-methyl-4H-chromen-4-one	0
4',5-Dihydroxy-3',7-dimethoxyisoflavone	0
4'-hydroxy-6,7-dimethoxyisoflavone	0
4'-methoxyisoflavones +	213
5,7-Dihydroxy-8,4'-dimethoxyisoflavone	0
5,7-Dimethoxyisoflavone	0
5,7-Trihydroxy-3',4'-dimethoxyisoflavone	0
5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-7-methoxy-8-methyl-4H-chromen-4-one	0
5-hydroxy-7-methoxy-3-(3-methoxyphenyl)-8-methyl-4H-chromen-4-one	0
5-hydroxy-7-methoxy-4′-O-(3-methylbut-2-enyl) isoflavone	0
7,4'-Di-O-methyldaidzein	0
7,4'-dihydroxy-3'-methoxyisoflavone	0
7,8-Dimethoxy-3',4'-methylenedioxyisoflavone	0
7-Geranylformononetin	0
7-Methoxy-2-methylisoflavone	0
7-O-Methylisolupalbigenin	0
7-O-methyl-8-chlorogenistein	0
7-hydroxy-5-methoxy-6,8-dimethylisoflavone	0
7-methoxyisoflavones +	7
Alfalone	0
Cabreuvin	0
Durlettone	0
Fujikinetin methyl ether	0
Gancaonin M	0
Glabrescione B	0
Irisolone methyl ether	0
Maduraktermol C	0
Maduraktermol I	0
Maduraktermol J	0
Maduraktermol K	0
Maximaisoflavone D	0
Maximaisoflavone J	0
Retusin 7-Methyl Ether	0
Santal	0
[4-(5-hydroxy-7-methoxy-8-methyl-4-oxo-4H-chromen-3-yl)-2-methoxyphenyl]oxidanesulfonic acid	0
betavulgarin	0
bowdichione	0
dalpatein	0
dihydrofuro-7-O-methylluteone	0
glycitein +	105
glycitein 4'-O-glucuronide	0
glycitein 7-(6-O-acetyl-beta-D-glucoside)	0
glycitein 7-O-beta-D-(2'',4'',6''-O-triacetyl)glucopyranoside	0
glycitin +	64
lmpk12050091	0
malonylglycitin	0
pierreione A	0
pierreione B	0
pierreione C	0
pierreione D	0
piscerythramine	0
pisonianone	0
tectoridin	8
tectorigenin +	28
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
organic molecule	20654
organic cyclic compound	20404
organic heterocyclic compound	19388
oxacycle	18300
benzopyran	12186
1-benzopyran	11917
isoflavonoid	3903
isoflavones	3883
methoxyisoflavone	318
2',5-Dihydroxy-4',7-dimethoxyisoflavone	0
2',7-Dihydroxy-4',5'-dimethoxyisoflavone	0
2'-Hydroxypiscerythrinetin	0
2'-Methoxyformonetin	0
2'-hydroxy-3'-methoxygenistein	0
2'-hydroxybiochanin A	0
3',4'-Dimethoxy-6,7-methylenedioxyisoflavone	0
3'-O-methylorobol	0
3'-methoxyisoflavones	0
3-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-8-methyl-4H-chromen-4-one	0
4',5-Dihydroxy-3',7-dimethoxyisoflavone	0
4'-hydroxy-6,7-dimethoxyisoflavone	0
4'-methoxyisoflavones +	213
5,7-Dihydroxy-8,4'-dimethoxyisoflavone	0
5,7-Dimethoxyisoflavone	0
5,7-Trihydroxy-3',4'-dimethoxyisoflavone	0
5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-7-methoxy-8-methyl-4H-chromen-4-one	0
5-hydroxy-7-methoxy-3-(3-methoxyphenyl)-8-methyl-4H-chromen-4-one	0
5-hydroxy-7-methoxy-4′-O-(3-methylbut-2-enyl) isoflavone	0
7,4'-Di-O-methyldaidzein	0
7,4'-dihydroxy-3'-methoxyisoflavone	0
7,8-Dimethoxy-3',4'-methylenedioxyisoflavone	0
7-Geranylformononetin	0
7-Methoxy-2-methylisoflavone	0
7-O-Methylisolupalbigenin	0
7-O-methyl-8-chlorogenistein	0
7-hydroxy-5-methoxy-6,8-dimethylisoflavone	0
7-methoxyisoflavones +	7
Alfalone	0
Cabreuvin	0
Durlettone	0
Fujikinetin methyl ether	0
Gancaonin M	0
Glabrescione B	0
Irisolone methyl ether	0
Maduraktermol C	0
Maduraktermol I	0
Maduraktermol J	0
Maduraktermol K	0
Maximaisoflavone D	0
Maximaisoflavone J	0
Retusin 7-Methyl Ether	0
Santal	0
[4-(5-hydroxy-7-methoxy-8-methyl-4-oxo-4H-chromen-3-yl)-2-methoxyphenyl]oxidanesulfonic acid	0
betavulgarin	0
bowdichione	0
dalpatein	0
dihydrofuro-7-O-methylluteone	0
glycitein +	105
glycitein 4'-O-glucuronide	0
glycitein 7-(6-O-acetyl-beta-D-glucoside)	0
glycitein 7-O-beta-D-(2'',4'',6''-O-triacetyl)glucopyranoside	0
glycitin +	64
lmpk12050091	0
malonylglycitin	0
pierreione A	0
pierreione B	0
pierreione C	0
pierreione D	0
piscerythramine	0
pisonianone	0
tectoridin	8
tectorigenin +	28

paths to the root