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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydroxyflavanone
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Accession:CHEBI:38749 term browser browse the term
Definition:Any hydroxyflavanone carrying two hydroxy substituents.
Synonyms:related_synonym: dihydroxyflavanones


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(+)-dihydromyricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] CTD PMID:21871475 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] CTD PMID:21871475 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] CTD PMID:21871475 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression
decreases activity 		ISO ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein 		CTD PMID:22251058 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082 		JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ar androgen receptor multiple interactions EXP Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of AR protein] CTD PMID:31797688 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO 		[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] 		CTD PMID:21477647 PMID:32061149 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO 		Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein] 		CTD PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 PMID:31797688 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of CEACAM1 protein] CTD PMID:35920545 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein] CTD PMID:35920545 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Eno2 enolase 2 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein] CTD PMID:35920545 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of and results in decreased activity of GPX1 protein] CTD PMID:35920545 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO 		Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein] 		CTD PMID:23665045 PMID:31797688 PMID:32061149 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]
Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of IL6 protein] 		CTD PMID:31797688 PMID:32061149 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions EXP Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of KLK3 protein] CTD PMID:31797688 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:29187079 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGER2 protein] CTD PMID:35920545 NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO 		Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] 		CTD PMID:23665045 PMID:29187079 PMID:31797688 PMID:32061149 PMID:35920545 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 PMID:29187079 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO 		Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]; Diosmin inhibits the reaction [Testosterone Propionate results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein] 		CTD PMID:23665045 PMID:31797688 PMID:32061149 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [bisphenol A diglycidyl ether co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Actg2 actin gamma 2, smooth muscle multiple interactions EXP hesperidin inhibits the reaction [ethanol increases expression of alpha SMA protein in liver parenchyma] RGD PMID:28320086 RGD:598130086 NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of AKT1 protein] CTD PMID:30779474 PMID:35413380 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
increases expression 		EXP Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]
Hesperidin results in increased expression of AKT2 mRNA 		CTD PMID:36966900 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Alb albumin multiple interactions
increases expression 		ISO
EXP 		[Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin inhibits the reaction [Dichlorvos results in decreased expression of ALB protein]
Hesperidin results in increased expression of ALB protein 		CTD PMID:29481770 PMID:39733793 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression 		EXP Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ATF6 mRNA]
Hesperidin results in decreased expression of ATF6 mRNA 		CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		[Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA] 		CTD PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		[Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Finasteride results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]
Hesperidin inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA] 		CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression 		EXP Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BECN1 protein]
Hesperidin results in decreased expression of BECN1 protein 		CTD PMID:33908150 PMID:34748272 PMID:35413380 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases activity
increases expression 		EXP
ISO 		[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Dichlorvos results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Finasteride results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]
Hesperidin results in decreased expression of CASP3 protein
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein 		CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity 		EXP
ISO 		Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Finasteride results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]
Hesperidin results in decreased activity of CAT protein
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein] 		CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]] CTD PMID:39987982 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]] CTD PMID:39987982 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 protein]
Hesperidin results in decreased expression of CCND1 mRNA; Hesperidin results in decreased expression of CCND1 protein 		CTD PMID:34984768 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression 		ISO BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 protein]
Hesperidin results in decreased expression of CDK4 mRNA; Hesperidin results in decreased expression of CDK4 protein 		CTD PMID:34984768 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression
multiple interactions 		ISO Hesperidin results in decreased expression of CDK6 mRNA; Hesperidin results in decreased expression of CDK6 protein
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 protein] 		CTD PMID:34984768 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A protein]
Hesperidin results in increased expression of CDKN1A mRNA; Hesperidin results in increased expression of CDKN1A protein 		CTD PMID:34984768 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression 		ISO BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B protein]
Hesperidin results in increased expression of CDKN1B mRNA; Hesperidin results in increased expression of CDKN1B protein 		CTD PMID:34984768 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]] CTD PMID:39987982 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression 		EXP Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA]
Hesperidin results in increased expression of EIF2AK3 mRNA 		CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA] CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Fabp9 fatty acid binding protein 9 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 2:93,499,136...93,503,267
Ensembl chr 2:93,499,134...93,503,260 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G G6pc3 glucose 6 phosphatase catalytic subunit 3 multiple interactions EXP Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr10:87,647,149...87,651,385
Ensembl chr10:87,647,062...87,653,453 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions 		ISO
EXP 		Hesperidin results in decreased activity of G6PD protein
Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein] 		CTD PMID:16427799 PMID:25130191 PMID:31345080 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gck glucokinase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity
multiple interactions 		ISO
EXP 		Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Dichlorvos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein 		CTD PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150 PMID:39733793 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO
EXP 		Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]
Hesperidin inhibits the reaction [Dichlorvos results in decreased activity of HMGCR protein] 		CTD PMID:16427799 PMID:39733793 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA] CTD PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA] CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Hesperidin inhibits the reaction [Dichlorvos results in decreased expression of IL10 mRNA] CTD PMID:39733793 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] 		CTD PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 PMID:35413380 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
hesperidin inhibits the reaction [ethanol increases expression of IL6 in liver]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] 		CTD
RGD		 PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 More... RGD:598130086 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA] CTD PMID:34748272 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lep leptin decreases expression
multiple interactions 		EXP Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein 		CTD PMID:21820093 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3A protein] CTD PMID:34748272 PMID:35413380 PMID:35921949 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3B protein] CTD PMID:34748272 PMID:35413380 PMID:35921949 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases phosphorylation ISO Hesperidin results in decreased phosphorylation of MAP2K5 protein CTD PMID:34984768 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA] CTD PMID:33908150 PMID:34748272 PMID:35921949 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO BIX 02189 promotes the reaction [Hesperidin results in decreased phosphorylation of MAPK7 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased phosphorylation of MAPK7 protein]; Hesperidin results in decreased phosphorylation of and affects the localization of MAPK7 protein CTD PMID:34984768 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mir126b microRNA 126b multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] CTD PMID:32050098 NCBI chr 3:29,813,174...29,813,246 JBrowse link
G Mir181a2 microRNA 181a-2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 3:43,025,563...43,025,679
Ensembl chr 3:43,025,563...43,025,679 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA] CTD PMID:35921949 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases secretion 		ISO
EXP 		Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein 		CTD PMID:19110045 PMID:20138977 PMID:35921949 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity 		EXP Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein 		CTD PMID:31095933 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of MTOR protein] CTD PMID:35413380 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression 		EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA]
Hesperidin results in increased expression of NFE2L2 mRNA 		CTD PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression 		EXP Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]
Hesperidin results in increased expression of NFKB1 mRNA 		CTD PMID:22093918 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]] CTD PMID:39987982 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO 		Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] 		CTD PMID:12512693 PMID:22093918 PMID:33908150 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 PMID:33908150 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO 		Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein] 		CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP 		Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA] 		CTD PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO 		Hesperidin inhibits the reaction [Dichlorvos results in increased expression of RELA mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein]
Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]] 		CTD PMID:30623541 PMID:39733793 PMID:39987982 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 9:87,211,155...87,331,787
Ensembl chr 9:87,211,717...87,333,132 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions ISO Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] CTD PMID:34800614 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA] CTD PMID:34748272 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tfeb transcription factor EB multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP hesperidin inhibits the reaction [ethanol increases expression of TGFbeta protein in serum] RGD PMID:28320086 RGD:598130086 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]] CTD PMID:39987982 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnc tenascin C multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		ISO
EXP 		Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]
Hesperidin results in decreased expression of TNF mRNA
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] 		CTD PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] CTD PMID:30066062 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 multiple interactions ISO TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]] CTD PMID:39987982 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:44,517,242...44,609,618 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression 		ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1 		CTD PMID:17400256 PMID:30991044 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein CTD PMID:33908150 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein] CTD PMID:34800614 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257 		JBrowse link
liquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP 		liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA] 		CTD PMID:31589899 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO liquiritigenin results in increased expression of CXCL12 mRNA CTD PMID:28396216 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO liquiritigenin results in decreased activity of CYP19A1 protein CTD PMID:38403145 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO liquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO liquiritigenin results in increased activity of ESR1 protein CTD PMID:28396216 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO liquiritigenin results in increased activity of ESR2 protein CTD PMID:25106122 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression 		EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
liquiritigenin results in increased expression of GCLC protein 		CTD PMID:29908794 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions 		EXP liquiritigenin results in increased expression of GCLM protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] 		CTD PMID:29908794 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] CTD PMID:31589899 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] CTD PMID:29908794 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO
EXP 		liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] 		CTD PMID:31589899 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA] 		CTD PMID:31589899 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions 		ISO
EXP 		NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] 		CTD PMID:29908794 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO 		liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] 		CTD PMID:31589899 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions 		ISO
EXP 		liquiritigenin results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] 		CTD PMID:26473469 PMID:29908794 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] 		CTD PMID:31589899 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 decreases activity ISO liquiritigenin results in decreased activity of TRPM3 protein CTD PMID:25361167 NCBI chr 1:229,099,741...229,984,172
Ensembl chr 1:229,099,542...229,984,172 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] CTD PMID:23183181 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022 		JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475 		JBrowse link
naringin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA CTD PMID:22198281 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein] CTD PMID:32172062 PMID:32810514 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [Caffeine results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ACHE protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22198281 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression 		ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein]
naringin results in decreased expression of ACP5 mRNA 		CTD PMID:21835177 PMID:24376342 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Ada adenosine deaminase multiple interactions EXP naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [Caffeine results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ADA protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:22198281 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Agt angiotensinogen multiple interactions ISO naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22798349 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions ISO naringin inhibits the reaction [Acetaminophen results in decreased expression of AKR7A5 protein] CTD PMID:35166444 NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		EXP
ISO 		2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA] 		CTD PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Angpt1 angiopoietin 1 affects expression EXP naringin affects the expression of ANGPT1 mRNA CTD PMID:24880026 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions 		ISO naringin results in increased expression of APAF1 protein
Acetylcysteine inhibits the reaction [naringin results in decreased expression of APAF1 protein] 		CTD PMID:39056589 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression 		EXP
ISO 		naringin inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA]
naringin results in increased expression of ATF6 protein 		CTD PMID:38037725 PMID:39056589 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:21835177 NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP
ISO 		naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA]
naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein] 		CTD PMID:21945202 PMID:30878453 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		naringin results in increased expression of BAX mRNA; naringin results in increased expression of BAX protein
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]
Acetylcysteine inhibits the reaction [naringin results in increased expression of BAX protein]; naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA] 		CTD PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] CTD PMID:32172062 PMID:32810514 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
naringin results in decreased expression of BCL2 protein
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]
naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] 		CTD PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 PMID:35166444 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
increases secretion
multiple interactions 		ISO
EXP 		naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein
naringin results in increased secretion of BGLAP protein
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein] 		CTD PMID:18495116 PMID:21741227 PMID:23596885 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO naringin results in increased expression of BID protein CTD PMID:39056589 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
decreases expression
increases secretion
increases expression 		ISO
EXP 		2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]
naringin results in decreased expression of BMP2 mRNA
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein 		CTD PMID:18495116 PMID:21820093 PMID:23596885 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Bmp3 bone morphogenetic protein 3 decreases expression ISO naringin results in decreased expression of BMP3 mRNA CTD PMID:18495116 NCBI chr14:11,012,564...11,041,282
Ensembl chr14:11,016,620...11,041,282 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO naringin results in increased expression of BMP4 mRNA CTD PMID:24915843 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Calcr calcitonin receptor multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA] CTD PMID:21835177 NCBI chr 4:32,615,955...32,691,075
Ensembl chr 4:32,615,958...32,691,075 		JBrowse link
G Casp12 caspase 12 increases expression ISO naringin results in increased expression of CASP12 protein CTD PMID:39056589 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO
EXP 		naringin results in increased expression of CASP3 mRNA
naringin inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein modified form]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CASP3 protein]
Acetylcysteine inhibits the reaction [naringin results in increased expression of and results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; naringin results in increased expression of and results in increased cleavage of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]] 		CTD PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
multiple interactions 		ISO
EXP 		naringin results in increased expression of CASP9 mRNA
naringin results in increased cleavage of CASP9 protein
[bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein] 		CTD PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514 More... Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO
EXP 		naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; naringin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein] 		CTD PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP 		naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA] 		CTD PMID:22965302 PMID:33992719 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:22965302 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein] CTD PMID:21500970 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
increases expression 		ISO
EXP 		naringin results in decreased expression of CCND1 protein
naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA]
Acetylcysteine inhibits the reaction [naringin results in decreased expression of CCND1 protein]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein]
naringin results in increased expression of CCND1 mRNA 		CTD PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO
EXP 		naringin results in decreased expression of CCNE1 protein CTD PMID:18296682 PMID:18951945 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression 		EXP
ISO 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; Acetylcysteine inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein 		CTD PMID:18296682 PMID:18951945 PMID:39056589 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein] 		CTD PMID:18296682 PMID:18951945 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein] 		CTD PMID:18296682 PMID:18951945 PMID:39056589 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 multiple interactions ISO CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of CHAC2 protein] CTD PMID:35166444 PMID:35179299 NCBI chr14:108,921,669...108,929,215
Ensembl chr14:108,921,341...108,929,469 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO naringin results in increased expression of COL1A1 mRNA CTD PMID:21741227 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA CTD PMID:22198281 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA] CTD PMID:21835177 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions 		ISO naringin results in increased expression of CTNNB1 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein] 		CTD PMID:24915843 PMID:26482937 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsb cathepsin B multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] CTD PMID:17188415 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Ctsk cathepsin K multiple interactions
decreases expression 		ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]
naringin results in decreased expression of CTSK mRNA 		CTD PMID:21835177 PMID:24376342 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP naringin results in increased expression of CXCL12 protein CTD PMID:29510123 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression ISO naringin affects the expression of CXCL2 mRNA CTD PMID:25117567 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP naringin results in increased expression of CXCR4 protein CTD PMID:29510123 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein] CTD PMID:25391245 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [naringin results in decreased expression of CYCS protein]; naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein]
naringin results in increased expression of CYCS protein 		CTD PMID:28422390 PMID:39056589 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA] CTD PMID:22798349 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP naringin inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA] CTD PMID:36598108 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO naringin results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO naringin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO naringin binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions 		ISO naringin results in decreased activity of CYP3A4 protein
naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] 		CTD PMID:16013069 PMID:21053930 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO naringin results in increased expression of DDIT3 protein CTD PMID:39056589 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO naringin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]] CTD PMID:26482937 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein] CTD PMID:22766066 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein] CTD PMID:22766066 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP naringin inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA] CTD PMID:38037725 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Endog endonuclease G increases expression ISO naringin results in increased expression of ENDOG protein CTD PMID:39056589 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression 		EXP
ISO 		naringin inhibits the reaction [Oxaliplatin results in increased expression of ERN1 mRNA]
naringin results in increased expression of ERN1 protein 		CTD PMID:38037725 PMID:39056589 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression 		EXP fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA] CTD PMID:23596885 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression 		EXP fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA] CTD PMID:23596885 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] CTD PMID:22198281 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO naringin results in increased expression of FADD mRNA CTD PMID:22847135 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO naringin results in increased expression of FAS mRNA CTD PMID:22847135 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:16427799 PMID:22198281 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression 		EXP fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA] CTD PMID:23596885 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]
naringin results in increased expression of FOS mRNA 		CTD PMID:18495116 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP naringin inhibits the reaction [Acrylamide results in decreased expression of FSHB protein] CTD PMID:36598108 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA] CTD PMID:16427799 PMID:22198281 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP
ISO 		naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]
naringin affects the reaction [LEPR protein affects the activity of G6PD protein] 		CTD PMID:16427799 PMID:20950607 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:17188415 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229 		JBrowse link
G Gck glucokinase multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression 		EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]; rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
naringin results in increased expression of GCLC mRNA; naringin results in increased expression of GCLC protein 		CTD PMID:22871521 PMID:25773745 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO naringin inhibits the reaction [Acetaminophen results in increased secretion of GOT1 protein] CTD PMID:35166444 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO 		naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; naringin inhibits the reaction [Oxaliplatin results in increased activity of GPT protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
naringin inhibits the reaction [Acetaminophen results in increased secretion of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein] 		CTD PMID:27174133 PMID:33992719 PMID:35166444 PMID:36811345 PMID:38037725 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases activity ISO naringin results in increased activity of GPX1 protein CTD PMID:23603004 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO 		naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]
naringin inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] 		CTD PMID:20950607 PMID:21945202 PMID:23650045 PMID:33992719 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions 		EXP naringin results in increased expression of GSTP1 mRNA
[naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA 		CTD PMID:22871521 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:17188415 NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP
ISO 		naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
naringin affects the reaction [LEPR protein affects the activity of HMGCR protein] 		CTD PMID:16427799 PMID:16906524 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
increases activity 		ISO
EXP 		CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]
naringin results in increased expression of HMOX1 mRNA; naringin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; naringin inhibits the reaction [Oxaliplatin results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
naringin results in increased activity of HMOX1 protein 		CTD PMID:22871521 PMID:23603004 PMID:25773745 PMID:27174133 PMID:35166444 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity 		ISO
EXP 		HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of HRAS protein 		CTD PMID:18296682 PMID:18951945 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression 		EXP
ISO 		naringin inhibits the reaction [Oxaliplatin results in increased expression of HSPA5 mRNA]
naringin results in increased expression of HSPA5 protein 		CTD PMID:38037725 PMID:39056589 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
affects expression 		ISO naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]
naringin affects the expression of ICAM1 mRNA 		CTD PMID:22074828 PMID:25117567 PMID:25391245 PMID:35166444 PMID:35179299 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions EXP naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA] CTD PMID:33992719 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifng interferon gamma multiple interactions
affects expression 		ISO naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]
naringin affects the expression of IFNG mRNA 		CTD PMID:16945185 PMID:21500970 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
multiple interactions
increases expression 		EXP
ISO 		naringin affects the expression of IGF1 mRNA
naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]
naringin results in increased expression of IGF1 mRNA
fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA] 		CTD PMID:23596885 PMID:24880026 PMID:30878453 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression 		EXP
ISO 		naringin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 protein]
naringin affects the expression of IL10 protein 		CTD PMID:22985397 PMID:25117567 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta affects expression
multiple interactions 		EXP
ISO 		naringin affects the expression of IL1B mRNA
[bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; naringin inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA] 		CTD PMID:24131540 PMID:24880026 PMID:30130594 PMID:32172062 PMID:32428650 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA] CTD PMID:33992719 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il2 interleukin 2 affects expression ISO naringin affects the expression of IL2 protein CTD PMID:25117567 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 affects expression ISO naringin affects the expression of IL4 protein CTD PMID:25117567 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 affects expression
multiple interactions
decreases expression 		EXP
ISO 		naringin affects the expression of IL6 mRNA
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
naringin results in decreased expression of IL6 protein
naringin affects the expression of IL6 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 protein] 		CTD PMID:16137700 PMID:19810018 PMID:21820093 PMID:24131540 PMID:24880026 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions
affects expression 		ISO
EXP 		naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]
naringin affects the expression of INS1 protein 		CTD PMID:24880026 PMID:29658312 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] CTD PMID:22198281 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]
naringin results in increased expression of JUN mRNA 		CTD PMID:18495116 PMID:35166444 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:36811345 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16906524 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] CTD PMID:17188415 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] CTD PMID:17188415 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408 		JBrowse link
G Lep leptin multiple interactions ISO
EXP 		naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein; naringin inhibits the reaction [Glucose results in increased expression of LEP protein] 		CTD PMID:21820093 PMID:22198281 PMID:24399619 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor multiple interactions ISO
EXP 		naringin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin affects the reaction [LEPR protein affects the activity of G6PD protein]; naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]; naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]; naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]
naringin inhibits the reaction [Glucose results in increased expression of LEPR protein] 		CTD PMID:16427799 PMID:24399619 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP naringin inhibits the reaction [Acrylamide results in decreased expression of LHB protein] CTD PMID:36598108 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein] CTD PMID:16906524 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of MAOA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation 		ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein] 		CTD PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK10 protein] CTD PMID:22198281 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP naringin inhibits the reaction [Acrylamide results in increased expression of MAPK14 mRNA] CTD PMID:36598108 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation 		ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in decreased phosphorylation of MAPK3 protein
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein] 		CTD PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein] CTD PMID:22198281 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein] CTD PMID:22198281 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mir126a microRNA 126a multiple interactions
increases expression 		ISO MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]
naringin results in increased expression of MIR126 mRNA 		CTD PMID:24975661 NCBI chr 3:29,813,150...29,813,267 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO naringin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26721195 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP 		naringin inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
naringin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringin results in decreased expression of and results in decreased activity of MMP9 protein
naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein] 		CTD PMID:19810018 PMID:22985397 PMID:23603004 PMID:25866363 PMID:26721195 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP naringin inhibits the reaction [Tobacco Smoke Pollution results in increased activity of MPO protein] CTD PMID:22985397 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO naringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein] CTD PMID:28422390 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein] CTD PMID:19810018 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein] 		CTD PMID:22766066 PMID:31301536 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization 		EXP
ISO 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; naringin inhibits the reaction [Oxaliplatin results in decreased expression of NFE2L2 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]] 		CTD PMID:22871521 PMID:25773745 PMID:27174133 PMID:35166444 PMID:35179299 More... NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP naringin inhibits the reaction [Cisplatin results in increased expression of NFKB1 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NFKB1 mRNA] CTD PMID:26120027 PMID:26612654 PMID:38037725 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha affects degradation
multiple interactions 		ISO naringin affects the degradation of NFKBIA protein
naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein] 		CTD PMID:21835177 PMID:25117567 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
multiple interactions 		ISO
EXP 		naringin affects the expression of NOS2 mRNA
naringin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NOS2 mRNA] 		CTD PMID:16137700 PMID:22871521 PMID:25117567 PMID:26612654 PMID:38037725 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein] CTD PMID:25391245 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression 		EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA
naringin results in increased expression of NQO1 mRNA 		CTD PMID:22871521 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO naringin results in increased cleavage of PARP1 protein CTD PMID:39056589 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA] CTD PMID:16427799 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of PDE5A protein]; naringin inhibits the reaction [Caffeine results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [potassium bromate results in increased activity of PDE5A protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3CA mRNA] CTD PMID:30878453 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:30878453 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22198281 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO
EXP 		naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] 		CTD PMID:16427799 PMID:22198281 PMID:30130594 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP naringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA] CTD PMID:18793633 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation
multiple interactions 		EXP naringin results in increased phosphorylation of PRKCD protein
rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein] 		CTD PMID:25773745 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions 		ISO
EXP 		naringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA] 		CTD PMID:16137700 PMID:22871521 PMID:25117567 PMID:35166444 PMID:35179299 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases activity
increases phosphorylation 		ISO
EXP 		RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of RAF1 protein
naringin results in increased phosphorylation of RAF1 protein 		CTD PMID:18296682 PMID:18951945 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein affects the localization of RELA protein]
naringin affects the expression of and affects the activity of RELA protein; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] 		CTD PMID:21500970 PMID:22766066 PMID:22965302 PMID:25117567 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15342961 PMID:19810018 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions 		ISO
EXP 		naringin results in increased expression of RUNX2 mRNA
naringin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA] 		CTD PMID:21741227 PMID:23596885 PMID:24915843 PMID:26482937 PMID:30878453 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP
ISO 		naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]
naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]] 		CTD PMID:18793633 PMID:36811345 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions EXP naringin inhibits the reaction [SLCO1A1 protein results in increased uptake of perfluorooctanoic acid] CTD PMID:19616083 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine] CTD PMID:24947867 PMID:25466967 PMID:27504015 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 PMID:22394605 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]] CTD PMID:21345335 PMID:35166444 PMID:35179299 PMID:36811345 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sp7 Sp7 transcription factor increases expression
multiple interactions 		EXP
ISO 		naringin results in increased expression of SP7 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA] 		CTD PMID:23596885 PMID:26482937 NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559 		JBrowse link
G Spn sialophorin multiple interactions
increases expression
decreases expression 		EXP [bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]
naringin results in increased expression of SPN protein
naringin results in decreased expression of SPN protein 		CTD PMID:32172062 PMID:32428650 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
increases secretion
multiple interactions 		ISO
EXP 		naringin results in increased expression of SPP1 mRNA; naringin results in increased expression of SPP1 protein
naringin results in increased secretion of SPP1 protein
fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein] 		CTD PMID:18495116 PMID:23596885 PMID:24915843 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22198281 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP naringin inhibits the reaction [Acrylamide results in decreased expression of STAR mRNA] CTD PMID:36598108 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO naringin affects the expression of STAT3 mRNA; naringin affects the expression of STAT3 protein CTD PMID:25117567 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
affects expression 		ISO
EXP 		naringin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of TGFB1 mRNA]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]
naringin affects the expression of TGFB1 mRNA 		CTD PMID:23603004 PMID:25117567 PMID:27174133 PMID:33992719 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 protein] CTD PMID:23603004 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression 		ISO
EXP 		naringin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
naringin affects the expression of TNF protein
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin affects the expression of TNF mRNA 		CTD PMID:16137700 PMID:19810018 PMID:21500970 PMID:22198281 PMID:22871521 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression ISO naringin results in decreased expression of TNFRSF11A mRNA CTD PMID:24376342 NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of TNFRSF11B protein] CTD PMID:30878453 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]; naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:21835177 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:17188415 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
decreases expression 		ISO
EXP 		naringin results in increased expression of TP53 mRNA
naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
naringin results in decreased expression of TP53 protein
[bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TP53 mRNA]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein] 		CTD PMID:22847135 PMID:26120027 PMID:26612654 PMID:32172062 PMID:32428650 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein] CTD PMID:24131540 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA] CTD PMID:22198281 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression 		ISO MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin results in decreased expression of VCAM1 mRNA; naringin results in decreased expression of VCAM1 protein 		CTD PMID:24975661 PMID:25391245 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfc vascular endothelial growth factor C affects expression EXP naringin affects the expression of VEGFC mRNA CTD PMID:24880026 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
neohesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [neohesperidin co-treated with Dietary Fats] results in increased expression of ACAA2 mRNA CTD PMID:32759940 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:32759940 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:32759940 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases expression ISO neohesperidin results in decreased expression of ACP5 mRNA CTD PMID:27664516 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO 		neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]
neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NOX4 mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA] 		CTD PMID:32531678 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Asip agouti signaling protein multiple interactions ISO neohesperidin inhibits the reaction [A mutant form results in increased expression of SCD1 mRNA] CTD PMID:25620042 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:164,015,903...164,021,378 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression 		ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]
neohesperidin results in increased expression of BGLAP mRNA; neohesperidin results in increased expression of BGLAP protein
SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP protein] 		CTD PMID:34020675 PMID:34455928 PMID:34919014 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
decreases methylation
multiple interactions 		ISO neohesperidin results in increased expression of BMP2 mRNA; neohesperidin results in increased expression of BMP2 protein
neohesperidin results in decreased methylation of BMP2 promoter
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA] 		CTD PMID:34020675 PMID:34919014 PMID:39067325 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Cat catalase multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA] CTD PMID:32759940 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CCL2 mRNA] CTD PMID:39547268 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO neohesperidin results in increased expression of CCND1 mRNA; neohesperidin results in increased expression of CCND1 protein CTD PMID:34919014 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:28554169 PMID:32759940 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects localization
increases expression 		ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of CTNNB1 mRNA]; neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; XAV939 inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]
neohesperidin affects the localization of CTNNB1 protein 		CTD PMID:34020675 PMID:34919014 PMID:39067325 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsk cathepsin K decreases expression ISO neohesperidin results in decreased expression of CTSK mRNA CTD PMID:27664516 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of CTNNB1 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of LEF1 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of MYC mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of TCF7 mRNA] 		CTD PMID:34020675 PMID:34919014 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650 		JBrowse link
G Dlx5 distal-less homeobox 5 multiple interactions
increases expression 		ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA] CTD PMID:34919014 NCBI chr 4:35,965,579...35,969,973
Ensembl chr 4:35,965,579...35,969,845 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]
neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of FASN mRNA] 		CTD PMID:28554169 PMID:32759940 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions 		ISO neohesperidin results in increased expression of FGF21 mRNA
neohesperidin promotes the reaction [Dietary Fats results in increased expression of FGF21 protein] 		CTD PMID:28554169 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056 		JBrowse link
G Gfap glial fibrillary acidic protein affects expression EXP neohesperidin affects the expression of GFAP protein CTD PMID:36331667 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:32759940 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32759940 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of HMGCR mRNA] CTD PMID:28554169 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion 		EXP Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of IFNG protein] CTD PMID:33604646 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of IL1A mRNA] CTD PMID:35150043 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta affects expression
multiple interactions 		EXP
ISO 		neohesperidin affects the expression of IL1B protein
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] 		CTD PMID:32759940 PMID:36331667 PMID:39547268 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il27 interleukin 27 multiple interactions
decreases secretion 		EXP Anisomycin inhibits the reaction [neohesperidin results in increased secretion of IL27 protein]
neohesperidin results in decreased secretion of IL27 protein 		CTD PMID:33604646 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion 		EXP Anisomycin inhibits the reaction [neohesperidin results in increased secretion of IL4 protein]
neohesperidin results in decreased secretion of IL4 protein 		CTD PMID:33604646 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion 		ISO
EXP 		[Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of IL6 mRNA]
neohesperidin results in decreased secretion of IL6 protein
Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of IL6 protein]
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA] 		CTD PMID:32759940 PMID:33604646 PMID:35150043 PMID:39547268 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irf5 interferon regulatory factor 5 affects expression EXP neohesperidin affects the expression of IRF5 protein CTD PMID:36331667 NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO neohesperidin results in increased expression of JUN mRNA; neohesperidin results in increased expression of JUN protein CTD PMID:34919014 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions 		ISO neohesperidin results in increased expression of LEF1 mRNA; neohesperidin results in increased expression of LEF1 protein
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of LEF1 mRNA] 		CTD PMID:34020675 PMID:34919014 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects phosphorylation 		ISO
EXP 		neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]
neohesperidin affects the phosphorylation of MAPK1 protein 		CTD PMID:32531678 PMID:36331667 PMID:39547268 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation 		ISO
EXP 		neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]
neohesperidin affects the phosphorylation of MAPK3 protein 		CTD PMID:32531678 PMID:36331667 PMID:39547268 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in increased expression of MPO protein] CTD PMID:32759940 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression 		ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of MYC mRNA]
neohesperidin results in increased expression of MYC mRNA; neohesperidin results in increased expression of MYC protein 		CTD PMID:34020675 PMID:34919014 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO neohesperidin inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA] CTD PMID:32531678 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO neohesperidin inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein] CTD PMID:27664516 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of NFE2L2 mRNA]; SR18292 inhibits the reaction [neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of NFE2L2 mRNA]] 		CTD PMID:32759940 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO neohesperidin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein] CTD PMID:27664516 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA] CTD PMID:34919014 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,625,875...74,628,103 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO neohesperidin inhibits the reaction [AGT protein results in increased expression of NOX4 mRNA] CTD PMID:32531678 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA] CTD PMID:32531678 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO
EXP 		neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA] CTD PMID:32531678 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G P2rx4 purinergic receptor P2X 4 affects expression EXP neohesperidin affects the expression of P2RX4 mRNA; neohesperidin affects the expression of P2RX4 protein CTD PMID:36331667 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PDK4 mRNA] CTD PMID:32759940 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression 		ISO neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA protein]
neohesperidin results in increased expression of PPARA mRNA
neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] 		CTD PMID:28554169 PMID:32759940 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [neohesperidin co-treated with Dietary Fats] results in increased expression of PPARGC1A protein; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA] CTD PMID:32759940 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein] CTD PMID:39547268 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation 		ISO
EXP 		neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of RELA protein]
neohesperidin results in decreased phosphorylation of RELA protein 		CTD PMID:33604646 PMID:39547268 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
increases expression 		ISO SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]
neohesperidin results in increased expression of RUNX2 mRNA; neohesperidin results in increased expression of RUNX2 protein 		CTD PMID:34020675 PMID:34455928 PMID:34919014 PMID:39067325 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO neohesperidin inhibits the reaction [A mutant form results in increased expression of SCD1 mRNA]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA] CTD PMID:25620042 PMID:32759940 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO neohesperidin results in increased expression of SIRT1 protein CTD PMID:28554169 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of SOD1 mRNA] CTD PMID:32759940 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions 		ISO neohesperidin results in increased expression of SPP1 mRNA
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA] 		CTD PMID:34919014 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]
neohesperidin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] 		CTD PMID:28554169 PMID:32759940 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tcf7 transcription factor 7 multiple interactions
increases expression 		ISO DKK1 protein inhibits the reaction [neohesperidin results in increased expression of TCF7 mRNA]
neohesperidin results in increased expression of TCF7 mRNA; neohesperidin results in increased expression of TCF7 protein 		CTD PMID:34020675 PMID:34919014 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of TFAM mRNA]; SR18292 inhibits the reaction [neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of TFAM mRNA]]
neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA] 		CTD PMID:32759940 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions 		EXP
ISO 		neohesperidin results in decreased secretion of TNF protein
Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of TNF protein]
[Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of TNF mRNA]
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA] 		CTD PMID:32759940 PMID:33604646 PMID:35150043 PMID:39547268 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression EXP neohesperidin affects the expression of TNFRSF1A protein CTD PMID:36331667 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO neohesperidin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; neohesperidin inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein] CTD PMID:27664516 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:32759940 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of VEGFA protein] CTD PMID:39547268 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
pinocembrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein] CTD PMID:33393179 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO pinocembrin results in decreased activity of CYP19A1 protein CTD PMID:38403145 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]] 		CTD PMID:33393179 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pinocembrin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects activity ISO pinocembrin affects the activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased activity of GPT protein] CTD PMID:33393179 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]] CTD PMID:18295389 PMID:33393179 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]] CTD PMID:18295389 PMID:33393179 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]] CTD PMID:33393179 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP 		SULT1A1 protein results in increased sulfation of pinocembrin CTD PMID:11181495 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] CTD PMID:18295389 NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53BP1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TRP53BP1 protein] 		CTD PMID:33393179 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747 		JBrowse link
sakuranetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO sakuranetin results in decreased activity of CYP19A1 protein CTD PMID:38403145 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
sophoranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO sophoranone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO sophoranone results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      molecular entity 20871
        polyatomic entity 20745
          heteroatomic molecular entity 20606
            hydroxides 19922
              organic hydroxy compound 19685
                hydroxyflavanone 579
                  dihydroxyflavanone 257
                    (+-)-chartaceone B 0
                    (+-)-chartaceone C 0
                    (+-)-chartaceone D 0
                    (+-)-chartaceone E 0
                    (+-)-chartaceone F 0
                    (-)-(2S)-5,2'-dihydroxy-6'',6''-dimethylchromeno-(7,8:2'',3'')-3'-prenylflavanone 0
                    (2S)-2'-methoxykurarinone 0
                    (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                    (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                    (2S)-6-(gamma,gamma-dimethylallyl)-5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                    (2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                    (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                    (2S)-8-methylpinocembrin 0
                    (2S)-carthamidin-4',7-dimethyl ether 0
                    (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                    2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one 0
                    3',5'-dihydroxyflavanone + 6
                    4',7-dihydroxyflavanone + 25
                    4'-methoxy-5,7-dihydroxyflavanone 0
                    7,4'-dihydroxy-8,3'-dimethoxyflavanone 0
                    7,8-dihydroxyflavanone 0
                    chartaceone A + 0
                    dihydrooroxylin A 0
                    diosmin 28
                    erylatissin C 0
                    glabranin 0
                    hesperetin 7-O-beta-D-glucoside 0
                    hesperidin 92
                    homoferreirin 0
                    leufolin A 0
                    leufolin B 0
                    maackiaflavanone A 0
                    maackiaflavanone B 0
                    matteucinol 0
                    myrciacitrin II 0
                    naringenin 7-O-beta-D-glucoside 0
                    naringenin 7-O-beta-D-glucuronide 0
                    naringin 172
                    narirutin 0
                    neohesperidin 62
                    pinocembrin 13
                    pisonivanol 0
                    prunin 6''-O-gallate 0
                    sakuranetin 1
                    selinone 0
                    sophoranone 3
                    strobopinin 0
                    tephrocandidin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  oxacycle 18273
                                    benzopyran 10790
                                      1-benzopyran 10376
                                        flavans 3662
                                          flavanones 597
                                            hydroxyflavanone 579
                                              dihydroxyflavanone 257
                                                (+-)-chartaceone B 0
                                                (+-)-chartaceone C 0
                                                (+-)-chartaceone D 0
                                                (+-)-chartaceone E 0
                                                (+-)-chartaceone F 0
                                                (-)-(2S)-5,2'-dihydroxy-6'',6''-dimethylchromeno-(7,8:2'',3'')-3'-prenylflavanone 0
                                                (2S)-2'-methoxykurarinone 0
                                                (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                                                (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                                                (2S)-6-(gamma,gamma-dimethylallyl)-5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                                                (2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                                                (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                                                (2S)-8-methylpinocembrin 0
                                                (2S)-carthamidin-4',7-dimethyl ether 0
                                                (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                                                2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one 0
                                                3',5'-dihydroxyflavanone + 6
                                                4',7-dihydroxyflavanone + 25
                                                4'-methoxy-5,7-dihydroxyflavanone 0
                                                7,4'-dihydroxy-8,3'-dimethoxyflavanone 0
                                                7,8-dihydroxyflavanone 0
                                                chartaceone A + 0
                                                dihydrooroxylin A 0
                                                diosmin 28
                                                erylatissin C 0
                                                glabranin 0
                                                hesperetin 7-O-beta-D-glucoside 0
                                                hesperidin 92
                                                homoferreirin 0
                                                leufolin A 0
                                                leufolin B 0
                                                maackiaflavanone A 0
                                                maackiaflavanone B 0
                                                matteucinol 0
                                                myrciacitrin II 0
                                                naringenin 7-O-beta-D-glucoside 0
                                                naringenin 7-O-beta-D-glucuronide 0
                                                naringin 172
                                                narirutin 0
                                                neohesperidin 62
                                                pinocembrin 13
                                                pisonivanol 0
                                                prunin 6''-O-gallate 0
                                                sakuranetin 1
                                                selinone 0
                                                sophoranone 3
                                                strobopinin 0
                                                tephrocandidin B 0
paths to the root