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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:parathion-methyl
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Accession:CHEBI:38746 term browser browse the term
Definition:A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Synonyms:exact_synonym: O,O-dimethyl O-(4-nitrophenyl) phosphorothioate
 related_synonym: Dimethyl p-nitrophenyl thiophosphate;   Dimethyl parathion;   Formula=C8H10NO5PS;   InChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3;   InChIKey=RLBIQVVOMOPOHC-UHFFFAOYSA-N;   Methylparathion;   O,O-Dimethyl O-(p-nitrophenyl) thionophosphate;   Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester;   Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester;   SMILES=COP(=S)(OC)Oc1ccc(cc1)[N+]([O-])=O
 xref: Beilstein:1914724;   CAS:298-00-0;   KEGG:C14228
 xref_mesh: MESH:D008743
 xref: PMID:14188063;   PMID:17852161;   PMID:24468856;   PMID:24470377;   PMID:24657944;   PPDB:507;   Pesticides:parathion-methyl



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parathion-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with decamethrin] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with Parathion] results in decreased activity of ACHE protein
Methyl Parathion results in decreased activity of ACHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with NADP] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Phenobarbital inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]
CTD PMID:1455421 PMID:1512808 PMID:2241428 PMID:3247000 PMID:3975908 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Add3 adducin 3 decreases expression
affects expression
increases expression
EXP Methyl Parathion results in decreased expression of ADD3 mRNA
Methyl Parathion affects the expression of ADD3 mRNA
Methyl Parathion results in increased expression of ADD3 mRNA
CTD PMID:19784758 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases activity
multiple interactions
increases expression
ISO Methyl Parathion results in increased activity of AKR1C1 protein
AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA]
Methyl Parathion results in increased expression of AKR1C1 mRNA
CTD PMID:19800895 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases activity
increases expression
ISO AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]
Methyl Parathion results in increased expression of AKR1C2 mRNA
CTD PMID:19800895 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Alb albumin affects binding ISO Methyl Parathion binds to ALB protein CTD PMID:14700528 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO
EXP
Dihydrotestosterone inhibits the reaction [Methyl Parathion results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]
Methyl Parathion binds to AR protein
CTD PMID:14565775 PMID:15064155 PMID:18324785 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Methyl Parathion results in decreased expression of BAX mRNA CTD PMID:29319433 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein
Methyl Parathion results in decreased activity of BCHE protein
CTD PMID:1512808 PMID:11405414 PMID:11481665 PMID:17963125 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methyl Parathion results in increased expression of BDNF mRNA; Methyl Parathion results in increased expression of BDNF protein CTD PMID:17893397 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 increases activity EXP Methyl Parathion results in increased activity of CASP3 protein CTD PMID:27941166 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity EXP Methyl Parathion results in increased activity of CASP9 protein CTD PMID:27941166 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity EXP Methyl Parathion results in increased activity of CAT protein CTD PMID:3975908 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin affects expression
decreases expression
increases expression
EXP Methyl Parathion affects the expression of CCK mRNA
Methyl Parathion results in decreased expression of CCK mRNA
Methyl Parathion results in increased expression of CCK mRNA
CTD PMID:19784758 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Methyl Parathion results in increased expression of CDKN1A mRNA CTD PMID:18418871 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM1 protein
Methyl Parathion results in decreased expression of CHRM1 protein
CTD PMID:14746346 PMID:16645783 PMID:17666426 PMID:18650256 PMID:30035273 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM2 protein
Methyl Parathion results in decreased expression of CHRM2 protein
CTD PMID:14746346 PMID:16645783 PMID:17666426 PMID:18650256 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM3 protein
Methyl Parathion results in decreased expression of CHRM3 protein
CTD PMID:17666426 PMID:30035273 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 decreases activity EXP Methyl Parathion results in decreased activity of CHRM4 protein CTD PMID:17666426 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit increases expression EXP Methyl Parathion results in increased expression of CHRNA6 mRNA CTD PMID:18977431 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects expression EXP Methyl Parathion affects the expression of CHRNA7 mRNA CTD PMID:18977431 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Methyl Parathion results in increased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Methyl Parathion results in increased expression of CYP1A1 mRNA
Methyl Parathion inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:19800895 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methyl Parathion binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Methyl Parathion binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methyl Parathion results in increased expression of FOS mRNA CTD PMID:17893397 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP Methyl Parathion results in increased expression of GABBR2 mRNA CTD PMID:19784758 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 increases expression EXP Methyl Parathion results in increased expression of GABRR2 mRNA CTD PMID:19784758 NCBI chr 5:47,445,280...47,489,929
Ensembl chr 5:47,452,150...47,489,809
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Methyl Parathion results in increased expression of GADD45A mRNA CTD PMID:18418871 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta increases expression EXP Methyl Parathion results in increased expression of GP1BB mRNA CTD PMID:19784758 NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
JBrowse link
G Gsr glutathione-disulfide reductase affects expression EXP Methyl Parathion affects the expression of GSR protein CTD PMID:18571824 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
increases expression
ISO GSTA1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion
Methyl Parathion results in increased expression of GSTA1 mRNA; Methyl Parathion results in increased expression of GSTA1 protein
CTD PMID:15103050 PMID:21907274 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion CTD PMID:15103050 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gusb glucuronidase, beta decreases activity EXP Methyl Parathion results in decreased activity of GUSB protein CTD PMID:3008131 PMID:3008132 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Methyl Parathion results in increased expression of IL1B mRNA CTD PMID:26948828 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO Methyl Parathion results in increased expression of IL6 mRNA CTD PMID:26948828 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases activity
multiple interactions
ISO Methyl Parathion results in decreased activity of LCAT protein
Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
CTD PMID:4847537 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Maoa monoamine oxidase A increases activity EXP Methyl Parathion results in increased activity of MAOA protein CTD PMID:11495289 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Methyl Parathion results in decreased expression of MKI67 protein CTD PMID:18418871 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases methylation ISO Methyl Parathion results in increased methylation of NFE2L2 promoter CTD PMID:29540303 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor affects expression EXP Methyl Parathion affects the expression of NGF mRNA; Methyl Parathion affects the expression of NGF protein CTD PMID:17893397 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Methyl Parathion binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases methylation ISO Methyl Parathion results in increased methylation of OGG1 promoter CTD PMID:29540303 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression EXP Methyl Parathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
ISO Methyl Parathion results in decreased expression of and results in decreased activity of PON1 protein
Methyl Parathion results in decreased expression of PON1 mRNA
CTD PMID:26948828 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Methyl Parathion binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO Methyl Parathion results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression
affects expression
increases expression
EXP Methyl Parathion results in decreased expression of SRSF5 mRNA
Methyl Parathion affects the expression of SRSF5 mRNA
Methyl Parathion results in increased expression of SRSF5 mRNA
CTD PMID:19784758 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G St14 ST14 transmembrane serine protease matriptase affects expression
decreases expression
increases expression
EXP Methyl Parathion affects the expression of ST14 mRNA
Methyl Parathion results in decreased expression of ST14 mRNA
Methyl Parathion results in increased expression of ST14 mRNA
CTD PMID:19784758 NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517
JBrowse link
G Tgm1 transglutaminase 1 decreases expression EXP Methyl Parathion results in decreased expression of TGM1 mRNA CTD PMID:19784758 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression
affects expression
EXP Methyl Parathion results in increased expression of TIMP3 mRNA
Methyl Parathion affects the expression of TIMP3 mRNA
CTD PMID:19784758 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
ISO
EXP
Methyl Parathion results in increased expression of TNF mRNA
Methyl Parathion results in decreased expression of TNF mRNA
CTD PMID:26948828 PMID:29319433 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Methyl Parathion results in increased expression of TP53 mRNA CTD PMID:18418871 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      application 19773
        agrochemical 15405
          parathion-methyl 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      chalcogen 19727
                        oxygen atom 19696
                          oxygen molecular entity 19696
                            hydroxides 19452
                              oxoacid 18753
                                pnictogen oxoacid 11776
                                  phosphorus oxoacid 10743
                                    phosphoric acids 9753
                                      phosphoric acid 9753
                                        phosphoric acid derivative 9495
                                          phosphate 9495
                                            organic phosphate 9495
                                              organic thiophosphate 5888
                                                parathion-methyl 57
paths to the root