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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:parathion-methyl
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Accession:CHEBI:38746 term browser browse the term
Definition:A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Synonyms:exact_synonym: O,O-dimethyl O-(4-nitrophenyl) phosphorothioate
 related_synonym: Dimethyl p-nitrophenyl thiophosphate;   Dimethyl parathion;   Formula=C8H10NO5PS;   InChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3;   InChIKey=RLBIQVVOMOPOHC-UHFFFAOYSA-N;   Methylparathion;   O,O-Dimethyl O-(p-nitrophenyl) thionophosphate;   Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester;   Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester;   SMILES=COP(=S)(OC)Oc1ccc(cc1)[N+]([O-])=O
 xref: Beilstein:1914724;   CAS:298-00-0;   KEGG:C14228
 xref_mesh: MESH:D008743
 xref: PMID:14188063;   PMID:17852161;   PMID:24468856;   PMID:24470377;   PMID:24657944;   PPDB:507;   Pesticides:parathion-methyl



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parathion-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with decamethrin] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with Parathion] results in decreased activity of ACHE protein
Methyl Parathion results in decreased activity of ACHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with NADP] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Glutathione inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Phenobarbital inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]
CTD PMID:1455421 PMID:1512808 PMID:2241428 PMID:3247000 PMID:3975908 More... NCBI chr12:25,042,882...25,050,608 JBrowse link
G Add3 adducin 3 decreases expression
affects expression
increases expression
EXP Methyl Parathion results in decreased expression of ADD3 mRNA
Methyl Parathion affects the expression of ADD3 mRNA
Methyl Parathion results in increased expression of ADD3 mRNA
CTD PMID:19784758 NCBI chr 1:262,152,722...262,260,504 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases activity
multiple interactions
increases expression
ISO Methyl Parathion results in increased activity of AKR1C1 protein
AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA]
Methyl Parathion results in increased expression of AKR1C1 mRNA
CTD PMID:19800895 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases activity
increases expression
ISO AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]
Methyl Parathion results in increased expression of AKR1C2 mRNA
CTD PMID:19800895 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Alb albumin affects binding ISO Methyl Parathion binds to ALB protein CTD PMID:14700528 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO
EXP
Dihydrotestosterone inhibits the reaction [Methyl Parathion results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]
Methyl Parathion binds to AR protein
CTD PMID:14565775 PMID:15064155 PMID:18324785 PMID:33049310 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Methyl Parathion results in decreased expression of BAX mRNA CTD PMID:29319433 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein
Methyl Parathion results in decreased activity of BCHE protein
CTD PMID:1512808 PMID:11405414 PMID:11481665 PMID:17963125 NCBI chr 2:160,607,289...160,699,760 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methyl Parathion results in increased expression of BDNF mRNA; Methyl Parathion results in increased expression of BDNF protein CTD PMID:17893397 NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Casp3 caspase 3 increases activity EXP Methyl Parathion results in increased activity of CASP3 protein CTD PMID:27941166 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp9 caspase 9 increases activity EXP Methyl Parathion results in increased activity of CASP9 protein CTD PMID:27941166
G Cat catalase increases activity EXP Methyl Parathion results in increased activity of CAT protein CTD PMID:3975908 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cck cholecystokinin affects expression
decreases expression
increases expression
EXP Methyl Parathion affects the expression of CCK mRNA
Methyl Parathion results in decreased expression of CCK mRNA
Methyl Parathion results in increased expression of CCK mRNA
CTD PMID:19784758 NCBI chr 8:121,153,499...121,160,194 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Methyl Parathion results in increased expression of CDKN1A mRNA CTD PMID:18418871 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM1 protein
Methyl Parathion results in decreased expression of CHRM1 protein
CTD PMID:14746346 PMID:16645783 PMID:17666426 PMID:18650256 PMID:30035273 NCBI chr 1:205,567,226...205,583,001 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM2 protein
Methyl Parathion results in decreased expression of CHRM2 protein
CTD PMID:14746346 PMID:16645783 PMID:17666426 PMID:18650256 NCBI chr 4:65,981,136...66,116,128 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM3 protein
Methyl Parathion results in decreased expression of CHRM3 protein
CTD PMID:17666426 PMID:30035273 NCBI chr17:64,696,549...65,158,622 JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 decreases activity EXP Methyl Parathion results in decreased activity of CHRM4 protein CTD PMID:17666426 NCBI chr 3:98,349,080...98,356,821 JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit increases expression EXP Methyl Parathion results in increased expression of CHRNA6 mRNA CTD PMID:18977431 NCBI chr16:64,697,741...64,704,441 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects expression EXP Methyl Parathion affects the expression of CHRNA7 mRNA CTD PMID:18977431 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Methyl Parathion results in increased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:63,449,148...63,476,534 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Methyl Parathion results in increased expression of CYP1A1 mRNA
Methyl Parathion inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:19800895 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr 1:246,175,216...246,211,445 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr12:14,369,950...14,398,803 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methyl Parathion binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Methyl Parathion binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methyl Parathion results in increased expression of FOS mRNA CTD PMID:17893397 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP Methyl Parathion results in increased expression of GABBR2 mRNA CTD PMID:19784758 NCBI chr 5:60,947,517...61,288,104 JBrowse link
G Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 increases expression EXP Methyl Parathion results in increased expression of GABRR2 mRNA CTD PMID:19784758 NCBI chr 5:47,445,280...47,489,929 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Methyl Parathion results in increased expression of GADD45A mRNA CTD PMID:18418871 NCBI chr 4:97,484,497...97,486,799 JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta increases expression EXP Methyl Parathion results in increased expression of GP1BB mRNA CTD PMID:19784758 NCBI chr11:82,378,216...82,379,393 JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
EXP Methyl Parathion results in increased activity of GPT protein
Glutathione inhibits the reaction [Methyl Parathion results in increased activity of GPT protein]
CTD PMID:20100039 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsr glutathione-disulfide reductase affects expression EXP Methyl Parathion affects the expression of GSR protein CTD PMID:18571824 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
increases expression
ISO GSTA1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion
Methyl Parathion results in increased expression of GSTA1 mRNA; Methyl Parathion results in increased expression of GSTA1 protein
CTD PMID:15103050 PMID:21907274 NCBI chr 9:23,703,476...23,720,121 JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion CTD PMID:15103050 NCBI chr20:12,856,068...12,873,020 JBrowse link
G Gusb glucuronidase, beta decreases activity EXP Methyl Parathion results in decreased activity of GUSB protein CTD PMID:3008131 PMID:3008132 NCBI chr12:32,337,281...32,350,838 JBrowse link
G Il1b interleukin 1 beta increases expression ISO Methyl Parathion results in increased expression of IL1B mRNA CTD PMID:26948828 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 increases expression ISO Methyl Parathion results in increased expression of IL6 mRNA CTD PMID:26948828 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases activity
multiple interactions
ISO Methyl Parathion results in decreased activity of LCAT protein
Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
CTD PMID:4847537 NCBI chr19:33,834,748...33,838,214 JBrowse link
G Maoa monoamine oxidase A increases activity EXP Methyl Parathion results in increased activity of MAOA protein CTD PMID:11495289 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 NCBI chr 7:55,176,558...55,201,757 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Methyl Parathion results in decreased expression of MKI67 protein CTD PMID:18418871 NCBI chr 1:199,926,150...199,952,847 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases methylation ISO Methyl Parathion results in increased methylation of NFE2L2 promoter CTD PMID:29540303 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Ngf nerve growth factor affects expression EXP Methyl Parathion affects the expression of NGF mRNA; Methyl Parathion affects the expression of NGF protein CTD PMID:17893397 NCBI chr 2:192,589,580...192,642,971 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Methyl Parathion binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases methylation ISO Methyl Parathion results in increased methylation of OGG1 promoter CTD PMID:29540303 NCBI chr 4:148,030,237...148,037,599 JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression EXP Methyl Parathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr10:57,618,586...57,633,648 JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
ISO Methyl Parathion results in decreased expression of and results in decreased activity of PON1 protein
Methyl Parathion results in decreased expression of PON1 mRNA
CTD PMID:26948828 NCBI chr 4:34,261,312...34,292,327 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Methyl Parathion binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO Methyl Parathion results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:31,044,983...31,077,167 JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression
affects expression
increases expression
EXP Methyl Parathion results in decreased expression of SRSF5 mRNA
Methyl Parathion affects the expression of SRSF5 mRNA
Methyl Parathion results in increased expression of SRSF5 mRNA
CTD PMID:19784758 NCBI chr 6:100,605,165...100,610,192 JBrowse link
G St14 ST14 transmembrane serine protease matriptase affects expression
decreases expression
increases expression
EXP Methyl Parathion affects the expression of ST14 mRNA
Methyl Parathion results in decreased expression of ST14 mRNA
Methyl Parathion results in increased expression of ST14 mRNA
CTD PMID:19784758 NCBI chr 8:29,540,805...29,581,704 JBrowse link
G Tgm1 transglutaminase 1 decreases expression EXP Methyl Parathion results in decreased expression of TGM1 mRNA CTD PMID:19784758 NCBI chr15:29,191,039...29,206,000 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression
affects expression
EXP Methyl Parathion results in increased expression of TIMP3 mRNA
Methyl Parathion affects the expression of TIMP3 mRNA
CTD PMID:19784758 NCBI chr 7:19,408,539...19,459,558 JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
ISO
EXP
Methyl Parathion results in increased expression of TNF mRNA
Methyl Parathion results in decreased expression of TNF mRNA
CTD PMID:26948828 PMID:29319433 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tp53 tumor protein p53 increases expression
affects activity
ISO Methyl Parathion results in increased expression of TP53 mRNA
Methyl Parathion metabolite affects the activity of TP53 protein
CTD PMID:18418871 PMID:35435491 NCBI chr10:54,798,871...54,810,300 JBrowse link

Term paths to the root
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  CHEBI ontology 19898
    role 19869
      application 19715
        agrochemical 16889
          parathion-methyl 58
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19587
                        oxygen atom 19559
                          oxygen molecular entity 19559
                            hydroxides 19370
                              oxoacid 18810
                                pnictogen oxoacid 14984
                                  phosphorus oxoacid 14585
                                    phosphoric acids 13931
                                      phosphoric acid 13931
                                        phosphoric acid derivative 13841
                                          phosphate 13840
                                            organic phosphate 13840
                                              organic thiophosphate 8619
                                                parathion-methyl 58
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