CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tetrahydroxyflavanone
Accession: CHEBI:38742
browse the term
Definition: A hydroxyflavanone with at least four hydroxy substituents.
Synonyms: related_synonym: tetrahydroxyflavanones
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Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions
ISO
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA
CTD
PMID:29471006
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]
CTD
PMID:29471006
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:29471006
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:29471006
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:29471006
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD
PMID:29471006
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:29471006
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]
CTD
PMID:29471006
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]
CTD
PMID:29471006
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Il1b
interleukin 1 beta
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:29471006
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD
PMID:29471006
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29471006
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29471006
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
CTD
PMID:29471006
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29471006
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD
PMID:29471006
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
CTD
PMID:29471006
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD
PMID:29471006
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD
PMID:29471006
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:29471006
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf
tumor necrosis factor
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD
PMID:29471006
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29471006
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
eriocitrin results in increased expression of BAX protein
CTD
PMID:34724282
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
eriocitrin results in decreased expression of BCL2 protein
CTD
PMID:34724282
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp7
caspase 7
increases expression
ISO
eriocitrin results in increased expression of CASP7 protein
CTD
PMID:34724282
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression
ISO
eriocitrin results in increased expression of CASP9 protein
CTD
PMID:34724282
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
decreases expression
ISO
eriocitrin results in decreased expression of CCND1 protein
CTD
PMID:34724282
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Jak2
Janus kinase 2
decreases phosphorylation
ISO
eriocitrin results in decreased phosphorylation of JAK2 protein
CTD
PMID:34724282
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation
ISO
Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]
CTD
PMID:34724282
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
eriocitrin results in decreased expression of PCNA protein
CTD
PMID:34724282
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases phosphorylation
ISO
eriocitrin results in decreased phosphorylation of SRC protein
CTD
PMID:34724282
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
ISO
eriocitrin results in decreased phosphorylation of STAT3 protein
CTD
PMID:34724282
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]
CTD
PMID:20438634
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
decreases activity
ISO
eriodictyol results in decreased activity of ABCC1 protein
CTD
PMID:15670588
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Bcl2a1
BCL2-related protein A1
multiple interactions
ISO
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]
CTD
PMID:20438634
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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Cat
catalase
multiple interactions
EXP
eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]
CTD
PMID:28978146
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]
CTD
PMID:20438634
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
multiple interactions
ISO
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]
CTD
PMID:20438634
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
CTD
PMID:19426678
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cycs
cytochrome c, somatic
increases expression
ISO
eriodictyol results in increased expression of CYCS protein
CTD
PMID:37020356
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein]
CTD
PMID:28978146
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx4
glutathione peroxidase 4
decreases expression
ISO
eriodictyol results in decreased expression of GPX4 protein
CTD
PMID:37020356
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Gstp1
glutathione S-transferase pi 1
decreases activity
ISO
eriodictyol results in decreased activity of GSTP1 protein
CTD
PMID:15041478
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hmox1
heme oxygenase 1
increases expression decreases expression multiple interactions
ISO EXP
eriodictyol results in increased expression of HMOX1 protein eriodictyol results in decreased expression of HMOX1 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein] eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]
CTD
PMID:16799064 PMID:28978146 PMID:37020356
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
multiple interactions
ISO
eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
CTD
PMID:23942037
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD
PMID:21544733 PMID:31860763
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
CTD
PMID:20438634 PMID:21544733 PMID:31860763
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf3
interferon regulatory factor 3
multiple interactions
ISO
eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]
CTD
PMID:19426678
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD
PMID:21544733
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mpo
myeloperoxidase
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
CTD
PMID:31860763
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression decreases expression decreases phosphorylation multiple interactions
ISO EXP
eriodictyol results in increased expression of NFE2L2 protein eriodictyol results in decreased expression of NFE2L2 protein eriodictyol results in decreased phosphorylation of NFE2L2 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein] eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein] eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein
CTD
PMID:16799064 PMID:28978146 PMID:37020356
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD
PMID:20438634 PMID:21544733
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
CTD
PMID:31860763
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression multiple interactions
ISO
eriodictyol results in decreased expression of NQO1 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein]
CTD
PMID:37020356
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:31860763
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD
PMID:20438634
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
eriodictyol results in decreased expression of SLC7A11 protein
CTD
PMID:37020356
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tbk1
TANK-binding kinase 1
decreases activity
ISO
eriodictyol results in decreased activity of TBK1 protein
CTD
PMID:19426678
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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Tnf
tumor necrosis factor
multiple interactions decreases activity
ISO
eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] eriodictyol results in decreased activity of TNF protein
CTD
PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip3
TNF alpha induced protein 3
multiple interactions
ISO
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]
CTD
PMID:20438634
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
CTD
PMID:20438634
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]
CTD
PMID:29902531
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein]
CTD
PMID:29902531
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein]
CTD
PMID:29902531
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Casp3
caspase 3
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]
CTD
PMID:29902531
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]
CTD
PMID:29902531
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]
CTD
PMID:31850465
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
homoeriodictyol results in decreased activity of CYP1A1 protein
CTD
PMID:10781868
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
homoeriodictyol results in decreased activity of CYP1B1 protein
CTD
PMID:10781868
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
homoeriodictyol results in increased expression of GCLM mRNA
CTD
PMID:29902531
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Ghrl
ghrelin and obestatin prepropeptide
multiple interactions
ISO
[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein
CTD
PMID:28834253
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
CTD
PMID:31850465
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
G
Il1b
interleukin 1 beta
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:31850465
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:31850465
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
CTD
PMID:29902531
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD
PMID:31850465
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:31850465
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression multiple interactions
ISO
homoeriodictyol results in increased expression of NQO1 mRNA NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
CTD
PMID:29902531
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]
CTD
PMID:29902531
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:31850465
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein]
CTD
PMID:31850465
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tnf
tumor necrosis factor
multiple interactions
ISO
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:31850465
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions
ISO
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA
CTD
PMID:29471006
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]
CTD
PMID:29471006
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:29471006
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:29471006
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:29471006
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD
PMID:29471006
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:29471006
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]
CTD
PMID:29471006
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]
CTD
PMID:29471006
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Il1b
interleukin 1 beta
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:29471006
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD
PMID:29471006
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29471006
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29471006
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
CTD
PMID:29471006
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29471006
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD
PMID:29471006
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
CTD
PMID:29471006
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD
PMID:29471006
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD
PMID:29471006
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:29471006
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tnf
tumor necrosis factor
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein] astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
CTD
PMID:29471006
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29471006
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Bglap
bone gamma-carboxyglutamate protein
multiple interactions increases expression
ISO
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA] neoeriocitrin results in increased expression of BGLAP mRNA
CTD
PMID:21741227
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
G
Col1a1
collagen type I alpha 1 chain
multiple interactions increases expression
ISO
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA] neoeriocitrin results in increased expression of COL1A1 mRNA
CTD
PMID:21741227
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Runx2
RUNX family transcription factor 2
increases expression
ISO
neoeriocitrin results in increased expression of RUNX2 mRNA
CTD
PMID:21741227
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19831
chemical entity
19829
molecular entity
19829
polyatomic entity
19787
heteroatomic molecular entity
19743
hydroxides
19320
organic hydroxy compound
18948
hydroxyflavanone
544
tetrahydroxyflavanone
57
(+)-dihydrokaempferol +
0
(+)-epitaxifolin 3-O-alpha-D-arabinopyranoside
0
(+)-taxifolin 3-O-acetate
0
(+)-taxifolin 3-O-alpha-D-arabinopyranoside
0
(+)-taxifolin 3-O-alpha-L-arabinofuranoside
0
(+)-taxifolin 3-O-alpha-L-arabinopyranoside
0
(+)-taxifolin 3-O-beta-D-arabinopyranoside
0
(+)-taxifolin 3-O-beta-D-xylopyranoside
0
(-)-epitaxifolin 3-O-alpha-D-arabinopyranoside
0
(-)-taxifolin 3-O-beta-D-xylopyranoside
0
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
0
(S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one
0
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one +
0
5,7,3',5'-tetrahydroxyflavanone
0
astilbin
22
carthamidin +
0
dihydroisorhamnetin +
0
eriodictyol +
51
exiguaflavanone A
0
fustin +
0
isonymphaeol B
0
leachianone G
0
lespeflorin B4
0
neoastilbin
22
nymphaeol A
0
nymphaeol B
0
nymphaeol C
0
plantagoside
0
remangiflavanone B
0
schizolaenone B
0
sigmoidin A
0
sigmoidin B
0
sophoraflavanone G
0
tanariflavanone C
0
tanariflavanone D
0
taxifolin 4'-methyl ether
0
Path 2
CHEBI ontology
19831
subatomic particle
19829
composite particle
19829
hadron
19829
baryon
19829
nucleon
19829
atomic nucleus
19829
atom
19829
main group element atom
19779
p-block element atom
19779
carbon group element atom
19728
carbon atom
19724
organic molecular entity
19724
organic molecule
19677
organic cyclic compound
19490
organic heterocyclic compound
18852
oxacycle
17838
benzopyran
11965
1-benzopyran
11716
flavonoid
7192
flavans
3636
flavanones
555
hydroxyflavanone
544
tetrahydroxyflavanone
57
(+)-dihydrokaempferol +
0
(+)-epitaxifolin 3-O-alpha-D-arabinopyranoside
0
(+)-taxifolin 3-O-acetate
0
(+)-taxifolin 3-O-alpha-D-arabinopyranoside
0
(+)-taxifolin 3-O-alpha-L-arabinofuranoside
0
(+)-taxifolin 3-O-alpha-L-arabinopyranoside
0
(+)-taxifolin 3-O-beta-D-arabinopyranoside
0
(+)-taxifolin 3-O-beta-D-xylopyranoside
0
(-)-epitaxifolin 3-O-alpha-D-arabinopyranoside
0
(-)-taxifolin 3-O-beta-D-xylopyranoside
0
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
0
(S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one
0
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one +
0
5,7,3',5'-tetrahydroxyflavanone
0
astilbin
22
carthamidin +
0
dihydroisorhamnetin +
0
eriodictyol +
51
exiguaflavanone A
0
fustin +
0
isonymphaeol B
0
leachianone G
0
lespeflorin B4
0
neoastilbin
22
nymphaeol A
0
nymphaeol B
0
nymphaeol C
0
plantagoside
0
remangiflavanone B
0
schizolaenone B
0
sigmoidin A
0
sigmoidin B
0
sophoraflavanone G
0
tanariflavanone C
0
tanariflavanone D
0
taxifolin 4'-methyl ether
0