Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoflavanones
go back to main search page
Accession:CHEBI:38741 term browser browse the term
Definition:Members of the class of isoflavans that have a 3,4-dihydro-3-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
Synonyms:related_synonym: Formula=C15O2R12;   SMILES=[*]c1c([*])c([*])c(c([*])c1[*])C1([*])C(=O)c2c([*])c([*])c([*])c([*])c2OC1([*])[*]


show annotations for term's descendants           Sort by:
 
alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator affects localization EXP alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
EXP [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein
CTD PMID:23850732 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions
EXP alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein
CTD PMID:23850732 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex decreases expression EXP alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CYCS cytochrome c, somatic affects localization EXP alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
EXP [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression EXP alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G STAT5A signal transducer and activator of transcription 5A multiple interactions EXP alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943
JBrowse link
G STAT6 signal transducer and activator of transcription 6 multiple interactions EXP alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr12:57,095,408...57,111,413
Ensembl chr12:57,095,408...57,132,139
JBrowse link
cajanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein CTD PMID:20638373 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP cajanol results in decreased expression of BCL2 protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein
cajanol results in increased activity of CASP3 protein
CTD PMID:20638373 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
EXP [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein
cajanol results in increased activity of CASP9 protein
CTD PMID:20638373 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP cajanol affects the localization of CYCS protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
Deguelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA] CTD PMID:22745725 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP deguelin results in increased expression of and affects the localization of AIFM1 protein CTD PMID:26592500 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases expression
affects phosphorylation
increases phosphorylation
multiple interactions
decreases phosphorylation
EXP
ISO
deguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 protein
deguelin affects the phosphorylation of AKT1 protein
deguelin results in increased phosphorylation of AKT1 protein
deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
deguelin results in decreased phosphorylation of AKT1 protein
CTD PMID:16288123 PMID:17015749 PMID:18593368 PMID:19139008 PMID:19336726 PMID:19901985 PMID:25322282 PMID:29512685 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ANGPTL4 angiopoietin like 4 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA] CTD PMID:22745725 NCBI chr19:8,364,129...8,374,373
Ensembl chr19:8,363,289...8,374,370
JBrowse link
G AR androgen receptor multiple interactions EXP deguelin results in decreased expression of and affects the localization of AR protein CTD PMID:27255535 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATM ATM serine/threonine kinase decreases expression EXP deguelin results in decreased expression of ATM mRNA CTD PMID:22227970 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATR ATR serine/threonine kinase decreases expression EXP deguelin results in decreased expression of ATR mRNA CTD PMID:22227970 NCBI chr 3:142,449,235...142,578,793
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP deguelin results in increased expression of BAK1 protein CTD PMID:26592500 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP deguelin results in increased expression of BAX mRNA; deguelin results in increased expression of BAX protein CTD PMID:26592500 PMID:29512685 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP deguelin results in decreased expression of BCL2 mRNA; deguelin results in decreased expression of BCL2 protein
deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
CTD PMID:19365708 PMID:22623043 PMID:26592500 PMID:29512685 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression
EXP deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]
deguelin results in decreased expression of BCL2L1 mRNA; deguelin results in decreased expression of BCL2L1 protein
CTD PMID:19365708 PMID:21472727 PMID:22623043 PMID:26592500 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions
decreases expression
EXP deguelin inhibits the reaction [docetaxel results in increased expression of BIRC5 protein]; deguelin inhibits the reaction [Doxorubicin results in increased expression of BIRC5 protein]
deguelin results in decreased expression of BIRC5 protein
CTD PMID:17035597 PMID:18593368 PMID:21472727 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BRCA1 BRCA1 DNA repair associated decreases expression EXP deguelin results in decreased expression of BRCA1 mRNA CTD PMID:22227970 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G CA9 carbonic anhydrase 9 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:22745725 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G CASP3 caspase 3 increases cleavage
multiple interactions
increases activity
EXP deguelin results in increased cleavage of CASP3 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein
deguelin results in increased activity of CASP3 protein
CTD PMID:18593368 PMID:19336726 PMID:22623043 PMID:22986522 PMID:25242579 PMID:26592500 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP6 caspase 6 multiple interactions EXP [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein CTD PMID:25242579 NCBI chr 4:109,688,628...109,703,445
Ensembl chr 4:109,688,622...109,703,583
JBrowse link
G CASP7 caspase 7 increases expression EXP deguelin metabolite results in increased expression of CASP7 protein modified form; deguelin results in increased expression of CASP7 protein modified form CTD PMID:19139008 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein CTD PMID:25242579 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO deguelin promotes the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA] CTD PMID:22745725 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:28529457 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15960896 PMID:17015749 PMID:19861542 PMID:21472727 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP deguelin results in decreased expression of CCNE1 mRNA CTD PMID:29512685 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CD14 CD14 molecule multiple interactions EXP [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein CTD PMID:25242579 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CD163 CD163 molecule multiple interactions ISO [deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA CTD PMID:22745725 NCBI chr12:7,470,811...7,503,808
Ensembl chr12:7,470,813...7,503,893
Ensembl chr12:7,470,813...7,503,893
JBrowse link
G CD44 CD44 molecule (Indian blood group) decreases expression EXP deguelin results in decreased expression of CD44 mRNA; deguelin results in decreased expression of CD44 protein CTD PMID:26884827 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDH1 cadherin 1 increases expression
multiple interactions
affects localization
EXP deguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 protein
deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]
deguelin affects the localization of CDH1 protein
CTD PMID:22986522 PMID:28509438 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 decreases expression EXP deguelin results in decreased expression of CDH2 protein CTD PMID:22986522 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDH3 cadherin 3 increases expression EXP deguelin results in increased expression of CDH3 mRNA CTD PMID:19861542 NCBI chr16:68,644,914...68,727,573
Ensembl chr16:68,636,189...68,722,616
JBrowse link
G CDH7 cadherin 7 increases expression EXP deguelin results in increased expression of CDH7 mRNA CTD PMID:19861542 NCBI chr18:65,750,252...65,890,337
Ensembl chr18:65,750,252...65,890,337
JBrowse link
G CDH9 cadherin 9 increases expression EXP deguelin results in increased expression of CDH9 mRNA CTD PMID:19861542 NCBI chr 5:26,880,597...27,038,586
Ensembl chr 5:26,880,597...27,121,150
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP deguelin metabolite results in decreased expression of CDK4 protein; deguelin results in decreased expression of CDK4 protein CTD PMID:19139008 PMID:19336726 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
increases expression
EXP [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; deguelin metabolite results in decreased expression of CDKN1A protein; deguelin results in decreased expression of CDKN1A protein
deguelin results in increased expression of CDKN1A mRNA
CTD PMID:19139008 PMID:25242579 PMID:29512685 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression EXP [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein CTD PMID:25242579 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
decreases expression
EXP deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
deguelin results in decreased expression of CFLAR mRNA
CTD PMID:22623043 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CLDN2 claudin 2 increases expression EXP deguelin results in increased expression of CLDN2 mRNA CTD PMID:19861542 NCBI chr  X:106,900,164...106,930,861
Ensembl chr  X:106,900,164...106,930,861
JBrowse link
G CLDN5 claudin 5 increases expression EXP deguelin results in increased expression of CLDN5 mRNA CTD PMID:19861542 NCBI chr22:19,523,024...19,525,337
Ensembl chr22:19,523,024...19,527,545
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions
decreases expression
increases degradation
EXP [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein] CTD PMID:21472727 PMID:22986522 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP deguelin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA] CTD PMID:22623043 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA] CTD PMID:22745725 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] CTD PMID:19961161 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DKK2 dickkopf WNT signaling pathway inhibitor 2 decreases expression EXP deguelin results in decreased expression of DKK2 mRNA CTD PMID:19861542 NCBI chr 4:106,921,802...107,036,313
Ensembl chr 4:106,921,802...107,283,806
JBrowse link
G DKK4 dickkopf WNT signaling pathway inhibitor 4 increases expression EXP deguelin results in increased expression of DKK4 mRNA CTD PMID:19861542 NCBI chr 8:42,373,194...42,391,322
Ensembl chr 8:42,374,063...42,377,229
JBrowse link
G EGFR epidermal growth factor receptor decreases expression EXP deguelin metabolite results in decreased expression of EGFR protein; deguelin results in decreased expression of EGFR protein CTD PMID:19139008 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA] CTD PMID:22745725 NCBI chr14:33,924,227...33,951,074
Ensembl chr14:33,924,227...34,462,774
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP deguelin results in increased phosphorylation of EIF2AK3 protein CTD PMID:25322282 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,627,464
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
decreases phosphorylation
EXP deguelin metabolite results in decreased expression of EIF4EBP1 protein modified form; deguelin results in decreased expression of EIF4EBP1 protein modified form
deguelin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:19139008 PMID:27255535 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G ENO2 enolase 2 decreases secretion EXP deguelin results in decreased secretion of ENO2 protein CTD PMID:26884827 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
JBrowse link
G ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] CTD PMID:27899277 NCBI chr10:95,710,901...95,877,266
Ensembl chr10:95,711,779...95,877,266
JBrowse link
G EPAS1 endothelial PAS domain protein 1 decreases expression EXP deguelin results in decreased expression of EPAS1 protein CTD PMID:19336726 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 decreases expression EXP deguelin results in decreased expression of ERN1 protein CTD PMID:25322282 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9270009 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FRZB frizzled related protein increases expression EXP deguelin results in increased expression of FRZB mRNA CTD PMID:19861542 NCBI chr 2:182,833,275...182,866,637
Ensembl chr 2:182,833,275...182,866,637
JBrowse link
G FZD10 frizzled class receptor 10 increases expression EXP deguelin results in increased expression of FZD10 mRNA CTD PMID:19861542 NCBI chr12:130,162,464...130,165,740
Ensembl chr12:130,162,459...130,165,740
JBrowse link
G FZD4 frizzled class receptor 4 increases expression EXP deguelin results in increased expression of FZD4 mRNA CTD PMID:19861542 NCBI chr11:86,945,679...86,955,395
Ensembl chr11:86,945,679...86,955,395
JBrowse link
G FZD8 frizzled class receptor 8 increases expression EXP deguelin results in increased expression of FZD8 mRNA CTD PMID:19861542 NCBI chr10:35,638,247...35,642,296
Ensembl chr10:35,638,249...35,642,278
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases phosphorylation EXP deguelin results in decreased phosphorylation of GSK3B protein CTD PMID:19336726 PMID:21472727 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases degradation
multiple interactions
EXP deguelin results in increased degradation of HIF1A protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:17764071 PMID:18575727 PMID:19139008 PMID:22745725 PMID:27899277 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17015749 PMID:22745725 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions ISO deguelin inhibits the reaction [Perfadex results in increased expression of IFNG protein]
[deguelin co-treated with OVAL protein] results in increased expression of IFNG protein
CTD PMID:22745725 PMID:28529457 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA] CTD PMID:17764071 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression EXP deguelin metabolite results in decreased expression of IGF1R protein; deguelin results in decreased expression of IGF1R protein CTD PMID:19139008 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IHH Indian hedgehog signaling molecule increases expression EXP deguelin results in increased expression of IHH mRNA CTD PMID:19861542 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921
JBrowse link
G IL10 interleukin 10 multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] CTD PMID:22745725 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL13 protein] CTD PMID:28529457 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL4 interleukin 4 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 protein]
CTD PMID:22745725 PMID:28529457 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL5 protein] CTD PMID:28529457 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 multiple interactions ISO deguelin inhibits the reaction [Perfadex results in decreased expression of IL6 protein] CTD PMID:22745725 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein CTD PMID:25242579 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP deguelin results in increased phosphorylation of JUN protein CTD PMID:25322282 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KDR kinase insert domain receptor decreases expression EXP deguelin metabolite results in decreased expression of KDR protein; deguelin results in decreased expression of KDR protein CTD PMID:19139008 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KRT18 keratin 18 increases expression
multiple interactions
EXP deguelin results in increased expression of KRT18 protein
deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]
CTD PMID:22986522 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G LOX lysyl oxidase multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:22745725 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,360
Ensembl chr 5:122,063,195...122,078,360
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 decreases expression EXP deguelin metabolite results in decreased expression of MAP2K1 protein; deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008 PMID:19336726 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases expression EXP deguelin results in decreased expression of MAP2K2 protein CTD PMID:19336726 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 decreases expression EXP deguelin results in decreased expression of MAP2K7 protein CTD PMID:25322282 NCBI chr19:7,903,785...7,914,478
Ensembl chr19:7,903,843...7,914,478
JBrowse link
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 affects expression EXP deguelin affects the expression of MAP3K3 protein CTD PMID:25322282 NCBI chr17:63,622,209...63,696,305
Ensembl chr17:63,622,415...63,696,303
Ensembl chr17:63,622,415...63,696,303
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects phosphorylation EXP deguelin affects the phosphorylation of MAPK1 protein CTD PMID:25322282 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects phosphorylation EXP deguelin affects the phosphorylation of MAPK3 protein CTD PMID:25322282 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP deguelin results in decreased expression of MCL1 protein CTD PMID:21472727 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase decreases expression EXP deguelin results in decreased expression of MGMT mRNA CTD PMID:22227970 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression EXP deguelin results in decreased expression of MKI67 protein CTD PMID:22623043 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression EXP deguelin results in decreased expression of MMP1 protein CTD PMID:25322282 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP13 matrix metallopeptidase 13 decreases expression EXP deguelin results in decreased expression of MMP13 protein CTD PMID:25322282 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP deguelin results in decreased expression of and results in decreased activity of MMP2 protein
deguelin results in decreased expression of MMP2 mRNA; deguelin results in decreased expression of MMP2 protein
CTD PMID:25322282 PMID:26884827 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP7 matrix metallopeptidase 7 decreases expression EXP deguelin results in decreased expression of MMP7 mRNA CTD PMID:25322282 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
EXP deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
deguelin results in decreased expression of MMP9 mRNA; deguelin results in decreased expression of MMP9 protein
deguelin results in decreased activity of MMP9 protein
CTD PMID:17015749 PMID:25322282 PMID:26884827 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO deguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA] CTD PMID:22745725 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases expression
decreases phosphorylation
EXP deguelin metabolite results in decreased expression of MTOR protein; deguelin results in decreased expression of MTOR protein
deguelin results in decreased phosphorylation of MTOR protein
CTD PMID:19139008 PMID:27255535 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA] CTD PMID:28529457 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
EXP
ISO
[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]
CTD PMID:9270009 PMID:17015749 PMID:21472727 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NCOA3 nuclear receptor coactivator 3 decreases expression EXP deguelin results in decreased expression of NCOA3 mRNA; deguelin results in decreased expression of NCOA3 protein CTD PMID:19365708 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
JBrowse link
G NEK2 NIMA related kinase 2 decreases expression EXP deguelin results in decreased expression of NEK2 mRNA; deguelin results in decreased expression of NEK2 protein CTD PMID:28509438 NCBI chr 1:211,658,256...211,675,625
Ensembl chr 1:211,658,657...211,675,630
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP
ISO
deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
deguelin inhibits the reaction [OVAL protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:17015749 PMID:22623043 PMID:28529457 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
deguelin results in decreased expression of NOS2 protein
deguelin inhibits the reaction [OVAL protein results in increased expression of NOS2 mRNA]
CTD PMID:25322282 PMID:28529457 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP deguelin results in decreased expression of NOS3 protein CTD PMID:19336726 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NPM1 nucleophosmin 1 decreases expression
multiple interactions
increases response to substance
EXP [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein
CTD PMID:25242579 NCBI chr 5:171,387,116...171,410,900
Ensembl chr 5:171,387,116...171,411,137
Ensembl chr 5:171,387,116...171,411,137
JBrowse link
G NT5E 5'-nucleotidase ecto multiple interactions EXP deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein] CTD PMID:27899277 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
JBrowse link
G NUP98 nucleoporin 98 and 96 precursor decreases expression EXP deguelin results in decreased expression of NUP98 mRNA; deguelin results in decreased expression of NUP98 protein CTD PMID:17490514 NCBI chr11:3,675,010...3,797,554
Ensembl chr11:3,671,083...3,797,792
JBrowse link
G ODC1 ornithine decarboxylase 1 increases activity
multiple interactions
EXP
ISO
deguelin results in increased activity of ODC1 protein
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]; deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
CTD PMID:9270009 PMID:9834970 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
EXP [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]
deguelin results in increased cleavage of PARP1 protein
deguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified form
CTD PMID:17015749 PMID:17035597 PMID:19139008 PMID:22986522 PMID:25242579 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 decreases expression EXP deguelin metabolite results in decreased expression of PDK1 protein; deguelin results in decreased expression of PDK1 protein CTD PMID:19139008 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha decreases expression EXP deguelin metabolite results in decreased expression of PIK3CA protein; deguelin results in decreased expression of PIK3CA protein CTD PMID:19139008 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PLCG1 phospholipase C gamma 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr20:41,137,519...41,177,626
Ensembl chr20:41,136,960...41,196,801
JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr17:39,626,735...39,636,625
Ensembl chr17:39,626,740...39,636,626
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 5:40,759,379...40,798,195
Ensembl chr 5:40,759,379...40,798,374
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit decreases expression EXP deguelin results in decreased expression of PRKDC mRNA CTD PMID:22227970 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
deguelin results in decreased expression of PTGS2 protein
CTD PMID:17015749 PMID:25322282 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 decreases expression EXP deguelin results in decreased expression of PTK2 protein CTD PMID:25322282 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G RAC1 Rac family small GTPase 1 decreases expression EXP deguelin results in decreased expression of RAC1 protein CTD PMID:26884827 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP deguelin results in decreased expression of RB1 protein CTD PMID:15960896 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
decreases phosphorylation
EXP
ISO
deguelin results in decreased expression of RELA mRNA; deguelin results in decreased expression of RELA protein
deguelin inhibits the reaction [OVAL protein affects the localization of and results in increased phosphorylation of RELA protein]
deguelin results in decreased phosphorylation of RELA protein
deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
CTD PMID:17015749 PMID:19365708 PMID:22623043 PMID:28529457 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A decreases expression EXP deguelin results in decreased expression of RHOA mRNA; deguelin results in decreased expression of RHOA protein CTD PMID:25322282 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 decreases expression EXP deguelin results in decreased expression of ROCK1 protein CTD PMID:25322282 PMID:26884827 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,946,906...21,111,813
JBrowse link
G RPS6 ribosomal protein S6 decreases expression
decreases phosphorylation
EXP deguelin metabolite results in decreased expression of RPS6 protein; deguelin metabolite results in decreased expression of RPS6 protein modified form; deguelin results in decreased expression of RPS6 protein; deguelin results in decreased expression of RPS6 protein modified form
deguelin results in decreased phosphorylation of RPS6 protein
CTD PMID:19139008 PMID:27255535 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases expression
decreases phosphorylation
EXP deguelin metabolite results in decreased expression of RPS6KB1 protein; deguelin results in decreased expression of RPS6KB1 protein
deguelin results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:19139008 PMID:27255535 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SELE selectin E multiple interactions EXP
ISO
deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of SELE mRNA]
CTD PMID:28529457 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SERPINB3 serpin family B member 3 decreases secretion EXP deguelin results in decreased secretion of SERPINB3 protein CTD PMID:26884827 NCBI chr18:63,655,197...63,661,893
Ensembl chr18:63,655,197...63,661,893
JBrowse link
G SFRP2 secreted frizzled related protein 2 decreases expression EXP deguelin results in decreased expression of SFRP2 mRNA CTD PMID:19861542 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083
JBrowse link
G SMAD3 SMAD family member 3 decreases phosphorylation EXP deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SMAD4 SMAD family member 4 multiple interactions EXP deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein] CTD PMID:22986522 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression
multiple interactions
EXP deguelin results in decreased expression of SNAI1 mRNA; deguelin results in decreased expression of SNAI1 protein
deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]
CTD PMID:19861542 PMID:22986522 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression EXP deguelin results in decreased expression of SOS1 protein CTD PMID:25322282 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,981,549...39,124,345
Ensembl chr 2:38,981,549...39,124,345
JBrowse link
G SOX14 SRY-box transcription factor 14 increases expression EXP deguelin results in increased expression of SOX14 mRNA CTD PMID:19861542 NCBI chr 3:137,764,315...137,766,334
Ensembl chr 3:137,764,315...137,766,334
JBrowse link
G SOX30 SRY-box transcription factor 30 increases expression EXP deguelin results in increased expression of SOX30 mRNA CTD PMID:19861542 NCBI chr 5:157,625,679...157,671,480
Ensembl chr 5:157,625,679...157,671,480
JBrowse link
G SOX5 SRY-box transcription factor 5 increases expression EXP deguelin results in increased expression of SOX5 mRNA CTD PMID:19861542 NCBI chr12:23,529,499...24,562,701
Ensembl chr12:23,529,504...24,562,544
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases activity EXP deguelin metabolite results in increased activity of SRC protein; deguelin results in increased activity of SRC protein CTD PMID:19139008 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases activity EXP deguelin metabolite results in increased activity of STAT3 protein; deguelin results in increased activity of STAT3 protein CTD PMID:19139008 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G STAT6 signal transducer and activator of transcription 6 increases phosphorylation EXP deguelin metabolite results in increased phosphorylation of STAT6 protein; deguelin results in increased phosphorylation of STAT6 protein CTD PMID:19139008 NCBI chr12:57,095,408...57,111,413
Ensembl chr12:57,095,408...57,132,139
JBrowse link
G STS steroid sulfatase multiple interactions EXP deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358
JBrowse link
G TCF4 transcription factor 4 increases expression EXP deguelin results in increased expression of TCF4 mRNA CTD PMID:19861542 NCBI chr18:55,222,185...55,635,957
Ensembl chr18:55,222,185...55,664,787
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:22986522 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP deguelin results in increased expression of TIMP1 protein CTD PMID:25322282 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP deguelin results in increased expression of TIMP2 protein CTD PMID:25322282 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MUC mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:17015749 PMID:22623043 PMID:28529457 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 decreases expression EXP [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein; deguelin results in decreased expression of TP53 mRNA CTD PMID:22227970 PMID:25242579 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions ISO
EXP
deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP protein]
deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]
CTD PMID:28529457 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression
decreases response to substance
EXP deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
deguelin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to deguelin
CTD PMID:17764071 PMID:18575727 PMID:22623043 PMID:22745725 PMID:25322282 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VIM vimentin decreases expression EXP deguelin results in decreased expression of VIM protein CTD PMID:22986522 PMID:28509438 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G WIF1 WNT inhibitory factor 1 increases expression EXP deguelin results in increased expression of WIF1 mRNA CTD PMID:19861542 NCBI chr12:65,050,626...65,121,305
Ensembl chr12:65,050,626...65,121,305
JBrowse link
G WNT10A Wnt family member 10A increases expression EXP deguelin results in increased expression of WNT10A mRNA CTD PMID:19861542 NCBI chr 2:218,874,116...218,893,931
Ensembl chr 2:218,880,852...218,899,581
JBrowse link
G WNT11 Wnt family member 11 increases expression EXP deguelin results in increased expression of WNT11 mRNA CTD PMID:19861542 NCBI chr11:76,186,325...76,210,842
Ensembl chr11:76,186,325...76,210,736
JBrowse link
G WNT2 Wnt family member 2 increases expression EXP deguelin results in increased expression of WNT2 mRNA CTD PMID:19861542 NCBI chr 7:117,275,451...117,323,058
Ensembl chr 7:117,275,451...117,323,152
JBrowse link
G WNT2B Wnt family member 2B decreases expression EXP deguelin results in decreased expression of WNT2B mRNA CTD PMID:19861542 NCBI chr 1:112,466,541...112,530,165
Ensembl chr 1:112,466,541...112,530,165
JBrowse link
G WNT3A Wnt family member 3A decreases expression EXP deguelin results in decreased expression of WNT3A mRNA CTD PMID:19861542 NCBI chr 1:228,006,998...228,067,113
Ensembl chr 1:228,006,998...228,061,271
JBrowse link
G WNT9A Wnt family member 9A decreases expression EXP deguelin results in decreased expression of WNT9A mRNA CTD PMID:19861542 NCBI chr 1:227,918,656...227,947,932
Ensembl chr 1:227,918,656...227,947,932
JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP deguelin results in decreased expression of XIAP protein CTD PMID:17035597 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976
JBrowse link
Osajin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase increases expression EXP osajin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) increases expression EXP osajin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) increases expression EXP osajin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G AR androgen receptor decreases expression EXP osajin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CD44 CD44 molecule (Indian blood group) increases expression EXP osajin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDH1 cadherin 1 increases expression EXP osajin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression EXP osajin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CYGB cytoglobin decreases expression EXP osajin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G DSG3 desmoglein 3 decreases expression EXP osajin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:31,447,741...31,478,712
Ensembl chr18:31,447,741...31,478,702
JBrowse link
G EGF epidermal growth factor decreases expression EXP osajin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP osajin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP osajin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G GRN granulin precursor increases expression EXP osajin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
JBrowse link
G HAS1 hyaluronan synthase 1 decreases expression EXP osajin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr19:51,713,112...51,723,991
Ensembl chr19:51,713,112...51,723,994
Ensembl chr19:51,713,112...51,723,994
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression EXP osajin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression EXP osajin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP osajin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G KL klotho decreases expression EXP osajin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr13:33,016,063...33,066,143
Ensembl chr13:33,016,423...33,066,143
JBrowse link
G KRT5 keratin 5 increases expression EXP osajin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr12:52,514,575...52,520,394
Ensembl chr12:52,514,575...52,520,530
JBrowse link
G MC1R melanocortin 1 receptor decreases expression EXP osajin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
Ensembl chr16:89,912,119...89,920,973
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP osajin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression EXP osajin results in decreased expression of NOS2 mRNA CTD PMID:20706672 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP osajin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PGR progesterone receptor decreases expression EXP osajin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 increases expression EXP osajin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420
JBrowse link
G POMC proopiomelanocortin decreases expression EXP osajin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP osajin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGER1 prostaglandin E receptor 1 decreases expression EXP osajin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:14,472,466...14,475,354
Ensembl chr19:14,472,466...14,475,354
JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein decreases expression EXP osajin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:12,945,846...12,953,642
Ensembl chr19:12,945,855...12,953,642
JBrowse link
G RARA retinoic acid receptor alpha increases expression EXP osajin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP osajin results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SOD3 superoxide dismutase 3 decreases expression EXP osajin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases expression EXP osajin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 2:31,522,480...31,665,651
Ensembl chr 2:31,522,480...31,580,938
JBrowse link
G TERT telomerase reverse transcriptase decreases expression EXP osajin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TPT1 tumor protein, translationally-controlled 1 increases expression EXP osajin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,370
Ensembl chr13:45,333,471...45,341,370
JBrowse link
G TXN thioredoxin increases expression EXP osajin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
Pomiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase increases expression EXP pomiferin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) increases expression EXP pomiferin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) increases expression EXP pomiferin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G AR androgen receptor decreases expression EXP pomiferin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CD44 CD44 molecule (Indian blood group) increases expression EXP pomiferin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDH1 cadherin 1 increases expression EXP pomiferin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression EXP pomiferin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CYGB cytoglobin decreases expression EXP pomiferin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G EGF epidermal growth factor decreases expression EXP pomiferin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP pomiferin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FBN1 fibrillin 1 decreases expression EXP pomiferin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,306...48,645,849
Ensembl chr15:48,408,306...48,645,849
JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP pomiferin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G GRN granulin precursor increases expression EXP pomiferin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression EXP pomiferin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression EXP pomiferin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G KL klotho decreases expression EXP pomiferin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr13:33,016,063...33,066,143
Ensembl chr13:33,016,423...33,066,143
JBrowse link
G KRT5 keratin 5 increases expression EXP pomiferin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr12:52,514,575...52,520,394
Ensembl chr12:52,514,575...52,520,530
JBrowse link
G MC1R melanocortin 1 receptor decreases expression EXP pomiferin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
Ensembl chr16:89,912,119...89,920,973
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP pomiferin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP pomiferin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PGR progesterone receptor decreases expression EXP pomiferin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 increases expression EXP pomiferin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420
JBrowse link
G POMC proopiomelanocortin decreases expression EXP pomiferin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP pomiferin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGER1 prostaglandin E receptor 1 decreases expression EXP pomiferin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:14,472,466...14,475,354
Ensembl chr19:14,472,466...14,475,354
JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein decreases expression EXP pomiferin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:12,945,846...12,953,642
Ensembl chr19:12,945,855...12,953,642
JBrowse link
G RARA retinoic acid receptor alpha increases expression EXP pomiferin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G SOD3 superoxide dismutase 3 decreases expression EXP pomiferin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases expression EXP pomiferin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 2:31,522,480...31,665,651
Ensembl chr 2:31,522,480...31,580,938
JBrowse link
G TERT telomerase reverse transcriptase decreases expression EXP pomiferin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TPT1 tumor protein, translationally-controlled 1 increases expression EXP pomiferin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,370
Ensembl chr13:45,333,471...45,341,370
JBrowse link
G TXN thioredoxin increases expression EXP pomiferin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TYRP1 tyrosinase related protein 1 decreases expression EXP pomiferin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24382
    chemical entity 24350
      group 24235
        inorganic group 23028
          oxo group 22155
            organic oxo compound 22155
              carbonyl compound 22155
                ketone 18352
                  cyclic ketone 14994
                    isoflavanones 185
                      (+)-Sophorol 0
                      (+-)-5-Deoxykievitone 0
                      (-)-Sophorol 0
                      3-(1,3-benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)-1-benzopyran-4-one 0
                      7-(1,3-benzodioxol-5-yl)-5-methoxy-2,2-dimethyl-6-pyrano[3,2-g][1]benzopyranone 0
                      Cyclokievitone 0
                      Deguelin 147
                      Euchretin A 0
                      Lachnoisoflavones A, (rac)- 0
                      Lachnoisoflavones B 0
                      Licoagroisoflavone 0
                      Millettone 0
                      Osajin 36
                      Pomiferin 33
                      Sumatrol 0
                      Toxicarol 0
                      alpinumisoflavone 14
                      hydroxyisoflavanone + 5
                      isoflavanone + 5
                      methoxyisoflavanone + 5
                      sophoraisoflavanone B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24382
    subatomic particle 24339
      composite particle 24339
        hadron 24339
          baryon 24339
            nucleon 24339
              atomic nucleus 24339
                atom 24339
                  main group element atom 24188
                    p-block element atom 24188
                      carbon group element atom 23967
                        carbon atom 23924
                          organic molecular entity 23924
                            organic molecule 23803
                              organic cyclic compound 23079
                                organic heterocyclic compound 21175
                                  oxacycle 19266
                                    benzopyran 10625
                                      1-benzopyran 10322
                                        isoflavonoid 3867
                                          isoflavans 225
                                            isoflavanones 185
                                              (+)-Sophorol 0
                                              (+-)-5-Deoxykievitone 0
                                              (-)-Sophorol 0
                                              3-(1,3-benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)-1-benzopyran-4-one 0
                                              7-(1,3-benzodioxol-5-yl)-5-methoxy-2,2-dimethyl-6-pyrano[3,2-g][1]benzopyranone 0
                                              Cyclokievitone 0
                                              Deguelin 147
                                              Euchretin A 0
                                              Lachnoisoflavones A, (rac)- 0
                                              Lachnoisoflavones B 0
                                              Licoagroisoflavone 0
                                              Millettone 0
                                              Osajin 36
                                              Pomiferin 33
                                              Sumatrol 0
                                              Toxicarol 0
                                              alpinumisoflavone 14
                                              hydroxyisoflavanone + 5
                                              isoflavanone + 5
                                              methoxyisoflavanone + 5
                                              sophoraisoflavanone B 0
paths to the root