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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trihydroxyflavanone
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Accession:CHEBI:38739 term browser browse the term
Definition:A hydroxyflavanone carrying three hydroxy substituents.
Synonyms:related_synonym: trihydroxyflavanones



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(S)-naringenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
multiple interactions
EXP naringenin results in increased expression of ABCB1 mRNA
naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
CTD PMID:19148864 PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions
increases activity
EXP [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione] CTD PMID:11306701 PMID:12485947 PMID:16156793 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) multiple interactions EXP naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions EXP naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO naringenin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:14709902 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA
naringenin metabolite results in increased expression of ADGRB1 mRNA
CTD PMID:36235125 NCBI chr 8:142,449,649...142,545,007
Ensembl chr 8:142,449,430...142,545,009
JBrowse link
G AFP alpha fetoprotein affects binding ISO naringenin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AHR aryl hydrocarbon receptor increases activity
multiple interactions
ISO
EXP
naringenin results in increased activity of AHR protein
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
CTD PMID:17869316 PMID:20450880 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 multiple interactions EXP naringenin binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP naringenin results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
naringenin inhibits the reaction [lead acetate results in decreased expression of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]
CTD PMID:22692793 PMID:22709785 PMID:25866363 PMID:36807407 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin multiple interactions ISO naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA] CTD PMID:31063766 PMID:37076581 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions EXP [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] CTD PMID:12650720 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of APAF1 mRNA; naringenin results in increased expression of APAF1 protein
[naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of APAF1 mRNA
CTD PMID:27838343 PMID:36235125 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15030205 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) multiple interactions EXP naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AQP5 aquaporin 5 multiple interactions EXP naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha increases expression EXP naringenin results in increased expression of ARHGDIA mRNA; naringenin results in increased expression of ARHGDIA protein CTD PMID:27838343 NCBI chr17:81,867,721...81,871,337
Ensembl chr17:81,867,721...81,871,378
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions EXP
ISO
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
CTD PMID:20450880 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of ATM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATM mRNA CTD PMID:36235125 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102
JBrowse link
G ATR ATR serine/threonine kinase multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of ATR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATR mRNA CTD PMID:36235125 NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G BACE1 beta-secretase 1 decreases activity EXP naringenin results in decreased activity of BACE1 protein CTD PMID:31194956 NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP naringenin results in increased expression of BAK1 protein CTD PMID:27838343 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]
naringenin results in decreased expression of BAX mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA]
CTD PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of BBC3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BBC3 mRNA CTD PMID:36235125 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCHE butyrylcholinesterase multiple interactions EXP naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein] CTD PMID:23085349 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
decreases response to substance
EXP
ISO
[naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]
naringenin results in decreased expression of BCL2 mRNA
naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:19124070 PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of BCL2A1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA
CTD PMID:36235125 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP naringenin results in decreased expression of BCL2L1 protein CTD PMID:27838343 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
increases expression
ISO naringenin inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]
naringenin results in increased expression of BDNF mRNA
CTD PMID:34655599 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of BIRC5 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BIRC5 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BIRC5 mRNA
CTD PMID:36235125 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BRCA1 BRCA1 DNA repair associated multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA CTD PMID:36235125 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G BRCA2 BRCA2 DNA repair associated increases expression
multiple interactions
EXP naringenin results in increased expression of BRCA2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BRCA2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA2 mRNA
CTD PMID:36235125 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
G BTG2 BTG anti-proliferation factor 2 multiple interactions
decreases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of BTG2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BTG2 mRNA
naringenin metabolite results in decreased expression of BTG2 mRNA
CTD PMID:36235125 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
JBrowse link
G CASP2 caspase 2 increases expression
multiple interactions
EXP naringenin results in increased expression of CASP2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CASP2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP2 mRNA
CTD PMID:36235125 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 increases activity
increases expression
multiple interactions
EXP
ISO
naringenin results in increased activity of CASP3 protein
naringenin results in increased expression of CASP3 mRNA
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
naringenin results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]; naringenin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
CTD PMID:19124070 PMID:22692793 PMID:23192364 PMID:27838343 PMID:31254498 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP7 caspase 7 increases expression EXP naringenin results in increased expression of CASP7 protein modified form CTD PMID:27838343 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
increases expression
EXP
ISO
naringenin results in increased activity of CASP9 protein
[naringenin co-treated with bisphenol A] results in increased expression of CASP9 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP9 mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]
naringenin metabolite results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 protein modified form
naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP9 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP9 mRNA]
CTD PMID:19124070 PMID:23192364 PMID:27838343 PMID:31254498 PMID:36235125 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases expression
increases activity
ISO naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of CAT protein]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; naringenin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringenin inhibits the reaction [Glucose results in decreased activity of CAT protein]; naringenin inhibits the reaction [lead acetate results in decreased activity of CAT protein]; naringenin inhibits the reaction [Paraquat results in increased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
naringenin results in decreased expression of CAT protein
naringenin analog results in increased activity of CAT protein; naringenin results in increased activity of CAT protein
naringenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD PMID:19063931 PMID:19409769 PMID:23192364 PMID:23283742 PMID:23845967 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNB1 mRNA CTD PMID:36235125 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP [Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA
naringenin results in decreased expression of CCND1 mRNA
CTD PMID:30153467 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 multiple interactions
decreases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA
naringenin results in decreased expression of CCNE1 mRNA
CTD PMID:30153467 PMID:36235125 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNG1 cyclin G1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in decreased expression of CCNG1 mRNA CTD PMID:36235125 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CCNH cyclin H multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNH mRNA CTD PMID:36235125 NCBI chr 5:87,311,471...87,412,930
Ensembl chr 5:87,318,416...87,413,029
JBrowse link
G CDC25A cell division cycle 25A multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of CDC25A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25A mRNA
naringenin metabolite results in increased expression of CDC25A mRNA
CTD PMID:36235125 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of CDC25C mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25C mRNA CTD PMID:36235125 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in decreased expression of CDK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDK1 mRNA CTD PMID:36235125 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of CDK4 mRNA CTD PMID:36235125 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of CDKN1A mRNA; naringenin results in increased expression of CDKN1A mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA
CTD PMID:30153467 PMID:36235125 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA CTD PMID:36235125 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA CTD PMID:36235125 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA CTD PMID:36235125 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO naringenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain increases expression
multiple interactions
EXP naringenin results in increased expression of CRADD mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CRADD mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CRADD mRNA
CTD PMID:36235125 NCBI chr12:93,677,375...93,894,840
Ensembl chr12:93,677,375...93,894,840
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
multiple interactions
ISO naringenin results in decreased expression of CTNNB1 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]
CTD PMID:34655599 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSD cathepsin D multiple interactions EXP [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:24586459 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein] CTD PMID:19135038 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions
increases expression
ISO
EXP
naringenin inhibits the reaction [Glucose affects the localization of CYCS protein]
naringenin results in increased expression of CYCS protein
CTD PMID:23192364 PMID:27838343 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions
decreases activity
EXP
ISO
naringenin binds to and results in decreased activity of CYP19A1 protein
naringenin results in decreased activity of CYP19A1 protein
CTD PMID:9435150 PMID:15319488 PMID:17895526 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
increases expression
EXP
ISO
naringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
naringenin results in decreased activity of CYP1A1 protein
naringenin results in increased expression of CYP1A1 mRNA
naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:11454723 PMID:20930378 PMID:21053930 PMID:27444380 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP naringenin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
increases expression
EXP
ISO
naringenin binds to and results in decreased activity of CYP1B1 protein
naringenin results in increased expression of CYP1B1 mRNA
CTD PMID:21053930 PMID:31621310 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP naringenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
decreases activity
EXP naringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
naringenin results in decreased activity of CYP2C9 protein
CTD PMID:21053930 PMID:29753067 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO
EXP
naringenin results in decreased activity of CYP2E1 protein CTD PMID:33007396 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
increases expression
EXP naringenin results in decreased activity of CYP3A4 protein
naringenin results in increased expression of CYP3A4 mRNA
CTD PMID:19148864 PMID:21053930 PMID:29753067 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DHRS12 dehydrogenase/reductase 12 decreases expression EXP naringenin results in decreased expression of DHRS12 mRNA; naringenin results in decreased expression of DHRS12 protein CTD PMID:27838343 NCBI chr13:51,754,854...51,804,163
Ensembl chr13:51,767,993...51,804,163
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA CTD PMID:36235125 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Paraquat results in decreased expression of DRD2 mRNA]
naringenin results in decreased expression of DRD2 mRNA
CTD PMID:34655599 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of E2F1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F1 mRNA CTD PMID:36235125 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G E2F3 E2F transcription factor 3 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of E2F3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F3 mRNA CTD PMID:36235125 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of EGFR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGFR mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein] CTD PMID:25866363 PMID:36235125 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of EGR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGR1 mRNA CTD PMID:36235125 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ESR1 estrogen receptor 1 affects activity
increases expression
decreases expression
affects binding
increases activity
multiple interactions
EXP
ISO
naringenin affects the activity of ESR1 protein
naringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNA
naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form
naringenin binds to ESR1 protein
naringenin results in increased activity of ESR1 protein
[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein
CTD PMID:9751507 PMID:10397250 PMID:10854714 PMID:12650720 PMID:15185748 More... NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases expression
increases activity
affects binding
EXP
ISO
[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; bisphenol A inhibits the reaction [naringenin metabolite results in increased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [naringenin results in increased expression of ESR2 mRNA]; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]
naringenin metabolite results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 protein
naringenin results in increased activity of ESR2 protein
naringenin binds to ESR2 protein
CTD PMID:9751507 PMID:12224631 PMID:16118406 PMID:16566672 PMID:17716812 More... NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FADD Fas associated via death domain multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of FADD mRNA CTD PMID:36235125 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390
JBrowse link
G FAS Fas cell surface death receptor increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of FAS mRNA
[naringenin co-treated with bisphenol A] results in increased expression of FAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FAS mRNA
CTD PMID:36235125 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASLG Fas ligand increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of FASLG mRNA
[naringenin co-treated with bisphenol A] results in increased expression of FASLG mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FASLG mRNA
CTD PMID:36235125 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO naringenin results in increased expression of FOS mRNA CTD PMID:28395574 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of FOXO3 mRNA CTD PMID:36235125 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions
decreases activity
ISO
EXP
[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]
naringenin results in decreased activity of G6PD protein
CTD PMID:19063931 PMID:25130191 PMID:25228019 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of GADD45A mRNA
[naringenin co-treated with bisphenol A] results in increased expression of GADD45A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GADD45A mRNA
CTD PMID:36235125 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
EXP naringenin results in increased expression of GCLC protein
NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]
CTD PMID:31254498 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein] CTD PMID:31254498 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GML glycosylphosphatidylinositol anchored molecule like increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of GML mRNA
[naringenin co-treated with bisphenol A] results in increased expression of GML mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GML mRNA
CTD PMID:36235125 NCBI chr 8:142,834,801...142,846,851
Ensembl chr 8:142,834,247...142,916,506
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions
decreases expression
EXP [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein
naringenin metabolite results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 protein
CTD PMID:30153467 PMID:36235125 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO naringenin inhibits the reaction [arsenic trioxide results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:23283742 PMID:29223569 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]
naringenin results in decreased expression of GPX1 protein
CTD PMID:23192364 PMID:28395574 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions
increases expression
EXP [Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA
naringenin results in increased expression of GPX2 mRNA
CTD PMID:24561720 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
JBrowse link
G GPX3 glutathione peroxidase 3 multiple interactions EXP [Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA CTD PMID:24561720 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GPX5 glutathione peroxidase 5 increases expression
multiple interactions
EXP naringenin results in increased expression of GPX5 mRNA
[Paraquat co-treated with naringenin] results in increased expression of GPX5 mRNA
CTD PMID:24561720 NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955
JBrowse link
G GPX7 glutathione peroxidase 7 multiple interactions
increases expression
EXP [Paraquat co-treated with naringenin] results in increased expression of GPX7 mRNA
naringenin results in increased expression of GPX7 mRNA
CTD PMID:24561720 NCBI chr 1:52,602,371...52,609,051
Ensembl chr 1:52,602,371...52,609,051
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases expression
ISO
EXP
naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; naringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA]
Paraquat inhibits the reaction [naringenin results in increased expression of GSR mRNA]
CTD PMID:19063931 PMID:23192364 PMID:24561720 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 multiple interactions
increases expression
EXP Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA] CTD PMID:24561720 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein] CTD PMID:23845967 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
JBrowse link
G HK2 hexokinase 2 multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of HK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of HK2 mRNA
naringenin metabolite results in increased expression of HK2 mRNA
CTD PMID:36235125 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin results in increased expression of and results in increased activity of HMOX1 protein; wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]
naringenin results in increased expression of HMOX1 mRNA; naringenin results in increased expression of HMOX1 protein
[Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA
naringenin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
CTD PMID:15316927 PMID:22709785 PMID:24561720 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of IGF1R mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IGF1R mRNA CTD PMID:36235125 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta increases expression ISO naringenin results in increased expression of IKBKB mRNA CTD PMID:28395574 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO naringenin inhibits the reaction [lead acetate results in increased expression of IL1B protein]
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:36807407 PMID:37880698 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP
ISO
[naringenin co-treated with bisphenol A] results in increased expression of IL6 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IL6 mRNA
naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]
naringenin metabolite results in increased expression of IL6 mRNA
CTD PMID:36235125 PMID:37076581 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
EXP
ISO
naringenin metabolite results in decreased expression of JUN mRNA; naringenin results in decreased expression of JUN mRNA
naringenin results in increased expression of JUN mRNA
CTD PMID:28395574 PMID:36235125 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KAT2B lysine acetyltransferase 2B increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of KAT2B mRNA
[naringenin co-treated with bisphenol A] results in increased expression of KAT2B mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of KAT2B mRNA
CTD PMID:36235125 NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
EXP Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein] CTD PMID:18057881 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KRAS KRAS proto-oncogene, GTPase multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNA CTD PMID:36235125 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein] CTD PMID:36807407 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G LPO lactoperoxidase increases expression
multiple interactions
EXP naringenin results in increased expression of LPO mRNA
Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA]
CTD PMID:24561720 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518
JBrowse link
G LRRC27 leucine rich repeat containing 27 increases expression EXP naringenin results in increased expression of LRRC27 mRNA; naringenin results in increased expression of LRRC27 protein CTD PMID:27838343 NCBI chr10:132,330,063...132,381,508
Ensembl chr10:132,332,154...132,381,508
JBrowse link
G LRRK2 leucine rich repeat kinase 2 decreases expression
multiple interactions
ISO naringenin results in decreased expression of LRRK2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of LRRK2 mRNA]
CTD PMID:34655599 NCBI chr12:40,224,997...40,369,285
Ensembl chr12:40,196,744...40,369,285
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 increases expression EXP naringenin results in increased expression of MAP3K5 protein CTD PMID:27838343 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases activity
decreases phosphorylation
ISO
EXP
naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
naringenin results in decreased activity of MAPK1 protein
naringenin results in decreased phosphorylation of MAPK1 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]
CTD PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases activity
decreases phosphorylation
ISO
EXP
naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
naringenin results in decreased activity of MAPK3 protein
naringenin results in decreased phosphorylation of MAPK3 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]
CTD PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP naringenin results in increased phosphorylation of MAPK8 protein CTD PMID:27838343 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP naringenin results in increased phosphorylation of MAPK9 protein CTD PMID:27838343 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of MCL1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MCL1 mRNA CTD PMID:36235125 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of MDM2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA
CTD PMID:36235125 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MDM4 MDM4 regulator of p53 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of MDM4 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM4 mRNA CTD PMID:36235125 NCBI chr 1:204,516,406...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G MIR141 microRNA 141 decreases expression EXP naringenin metabolite results in decreased expression of MIR141 mRNA CTD PMID:36235125 NCBI chr12:6,964,097...6,964,191
Ensembl chr12:6,964,097...6,964,191
JBrowse link
G MIR200C microRNA 200c multiple interactions EXP naringenin inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]; naringenin metabolite inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA] CTD PMID:36235125 NCBI chr12:6,963,699...6,963,766
Ensembl chr12:6,963,699...6,963,766
JBrowse link
G MLH1 mutL homolog 1 increases expression
multiple interactions
EXP naringenin results in increased expression of MLH1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MLH1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MLH1 mRNA
CTD PMID:36235125 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
multiple interactions
EXP naringenin results in decreased expression of MMP2 mRNA
naringenin results in decreased expression of and results in decreased activity of MMP2 protein
CTD PMID:30153467 PMID:30431227 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringenin results in decreased expression of and results in decreased activity of MMP9 protein
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]
naringenin results in decreased expression of MMP9 mRNA
CTD PMID:25866363 PMID:30153467 PMID:30431227 PMID:37880698 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MSH2 mutS homolog 2 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of MSH2 mRNA CTD PMID:36235125 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO naringenin inhibits the reaction [lead acetate results in decreased expression of MTOR protein] CTD PMID:36807407 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G MYOD1 myogenic differentiation 1 multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of MYOD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MYOD1 mRNA
naringenin metabolite results in increased expression of MYOD1 mRNA; naringenin results in increased expression of MYOD1 mRNA
CTD PMID:36235125 NCBI chr11:17,719,571...17,722,136
Ensembl chr11:17,719,571...17,722,136
JBrowse link
G NANOG Nanog homeobox decreases expression EXP naringenin results in decreased expression of NANOG protein CTD PMID:27468969 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146
JBrowse link
G NF1 neurofibromin 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of NF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NF1 mRNA CTD PMID:36235125 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
increases expression
EXP [naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; naringenin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]
naringenin results in increased activity of NFE2L2 protein
naringenin results in increased expression of NFE2L2 mRNA
CTD PMID:24561720 PMID:31254498 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of NFKB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NFKB1 mRNA CTD PMID:36235125 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO naringenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:10188978 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NFKBIL1 NFKB inhibitor like 1 increases expression EXP naringenin results in increased expression of NFKBIL1 mRNA; naringenin results in increased expression of NFKBIL1 protein CTD PMID:27838343 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829
JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 increases expression EXP naringenin results in increased expression of NME1 mRNA; naringenin results in increased expression of NME1 protein CTD PMID:27838343 NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:10188978 PMID:12512693 PMID:15316927 PMID:18274639 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP [Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA
naringenin results in increased expression of NQO1 mRNA; naringenin results in increased expression of NQO1 protein
CTD PMID:24561720 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP naringenin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP naringenin results in increased cleavage of PARP1 protein
naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]
CTD PMID:27838343 PMID:31254498 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of PCNA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PCNA mRNA CTD PMID:36235125 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PGD phosphogluconate dehydrogenase decreases activity EXP naringenin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PGR progesterone receptor increases expression
multiple interactions
ISO
EXP
naringenin results in increased expression of PGR mRNA
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA
CTD PMID:10397250 PMID:24586459 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PIDD1 p53-induced death domain protein 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of PIDD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PIDD1 mRNA CTD PMID:36235125 NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753
JBrowse link
G PON1 paraoxonase 1 increases expression EXP naringenin results in increased expression of PON1 mRNA CTD PMID:15169886 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein]
CTD PMID:31063766 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions ISO HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARB protein]
CTD PMID:31063766 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein]
CTD PMID:29223569 PMID:31063766 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PPM1D mRNA CTD PMID:36235125 NCBI chr17:60,600,193...60,666,280
Ensembl chr17:60,600,193...60,666,280
JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 protein CTD PMID:27838343 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PRKCA protein kinase C alpha multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PRKCA mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] CTD PMID:25866363 PMID:36235125 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCB protein kinase C beta multiple interactions EXP naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein] CTD PMID:25866363 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PRKCG protein kinase C gamma multiple interactions EXP naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein] CTD PMID:25866363 NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
G PROM1 prominin 1 decreases expression EXP naringenin results in decreased expression of PROM1 protein CTD PMID:27468969 NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378
JBrowse link
G PSEN2 presenilin 2 multiple interactions EXP [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA CTD PMID:24586459 NCBI chr 1:226,870,616...226,903,668
Ensembl chr 1:226,870,184...226,927,726
JBrowse link
G PTEN phosphatase and tensin homolog increases expression
multiple interactions
EXP naringenin results in increased expression of PTEN mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTEN mRNA
CTD PMID:36235125 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP naringenin results in increased expression of PTGS1 mRNA CTD PMID:24561720 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:21341175 PMID:27206700 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTTG1 PTTG1 regulator of sister chromatid separation, securin increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of PTTG1 mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTTG1 mRNA
CTD PMID:36235125 NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of RB1 mRNA CTD PMID:36235125 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO naringenin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
CTD PMID:18274639 PMID:27206700 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA
naringenin metabolite results in increased expression of RPRM mRNA; naringenin results in increased expression of RPRM mRNA
CTD PMID:36235125 NCBI chr 2:153,477,338...153,478,762
Ensembl chr 2:153,477,338...153,478,762
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 increases expression EXP naringenin results in increased expression of RPTOR mRNA; naringenin results in increased expression of RPTOR protein CTD PMID:27838343 NCBI chr17:80,544,838...80,966,368
Ensembl chr17:80,544,819...80,966,371
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22709785 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SESN2 sestrin 2 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of SESN2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SESN2 mRNA CTD PMID:36235125 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491
JBrowse link
G SHBG sex hormone binding globulin affects binding EXP naringenin binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G SI sucrase-isomaltase decreases activity
multiple interactions
ISO
EXP
naringenin results in decreased activity of SI protein
naringenin binds to and results in decreased activity of SI protein
CTD PMID:24412302 NCBI chr 3:164,978,898...165,157,921
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIAH1 mRNA CTD PMID:36235125 NCBI chr16:48,360,531...48,387,246
Ensembl chr16:48,356,364...48,448,402
JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA CTD PMID:36235125 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP
ISO
naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
[naringenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
CTD PMID:17108059 PMID:17976262 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions
decreases activity
EXP naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
naringenin results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP naringenin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr22:32,043,261...32,113,029
Ensembl chr22:32,043,261...32,113,029
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Paraquat results in decreased expression of SLC6A3 mRNA]
naringenin results in decreased expression of SLC6A3 mRNA
CTD PMID:34655599 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP naringenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression EXP naringenin results in decreased expression of SNAI1 protein CTD PMID:30431227 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 decreases expression EXP naringenin results in decreased expression of SNAI2 protein CTD PMID:30431227 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G SNCA synuclein alpha multiple interactions
increases expression
ISO naringenin inhibits the reaction [Paraquat results in increased expression of SNCA mRNA]
naringenin results in increased expression of SNCA mRNA
CTD PMID:34655599 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression EXP
ISO
naringenin results in increased expression of SOCS3 mRNA CTD PMID:23782265 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA]
naringenin results in decreased expression of SOD1 protein
CTD PMID:23192364 PMID:28395574 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA] CTD PMID:23192364 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP naringenin results in decreased expression of SOX2 protein CTD PMID:27468969 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA] CTD PMID:22709785 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in decreased expression of STAT1 mRNA CTD PMID:36235125 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation EXP naringenin results in decreased phosphorylation of STAT3 protein CTD PMID:27468969 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions EXP
ISO
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin] CTD PMID:11181495 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044
JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 increases sulfation EXP SULT1A3 protein results in increased sulfation of naringenin CTD PMID:11181495 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310
JBrowse link
G TADA3 transcriptional adaptor 3 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in decreased expression of TADA3 mRNA CTD PMID:36235125 NCBI chr 3:9,779,967...9,793,011
Ensembl chr 3:9,779,967...9,793,011
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
naringenin inhibits the reaction [lead acetate results in increased expression of TGFB1 protein]
CTD PMID:23845967 PMID:36807407 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase decreases expression
multiple interactions
ISO naringenin results in decreased expression of TH protein
naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein]
CTD PMID:34655599 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
decreases activity
EXP
ISO
[naringenin co-treated with bisphenol A] results in increased expression of TNF mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNF mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
naringenin metabolite results in increased expression of TNF mRNA
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]
naringenin results in decreased activity of TNF protein
naringenin inhibits the reaction [lead acetate results in increased expression of TNF protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]
CTD PMID:18720166 PMID:19135038 PMID:22709785 PMID:36235125 PMID:36807407 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of TNFRSF10B mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNFRSF10B mRNA CTD PMID:36235125 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFRSF10D TNF receptor superfamily member 10d multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of TNFRSF10D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNFRSF10D mRNA
naringenin results in increased expression of TNFRSF10D mRNA
CTD PMID:36235125 NCBI chr 8:23,135,588...23,164,027
Ensembl chr 8:23,135,588...23,164,027
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP [Tamoxifen co-treated with naringenin] results in increased expression of TP53 mRNA; naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; naringenin results in increased expression of and results in increased phosphorylation of TP53 protein
naringenin results in increased expression of TP53 mRNA
CTD PMID:15795422 PMID:27838343 PMID:30153467 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of TP53AIP1 mRNA; naringenin results in increased expression of TP53AIP1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of TP53AIP1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53AIP1 mRNA
CTD PMID:36235125 NCBI chr11:128,934,731...128,942,871
Ensembl chr11:128,934,731...128,943,399
JBrowse link
G TP53BP2 tumor protein p53 binding protein 2 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53BP2 mRNA CTD PMID:36235125 NCBI chr 1:223,779,893...223,845,947
Ensembl chr 1:223,779,893...223,845,954
JBrowse link
G TP63 tumor protein p63 multiple interactions
increases expression
EXP [naringenin co-treated with bisphenol A] results in increased expression of TP63 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP63 mRNA
naringenin metabolite results in increased expression of TP63 mRNA; naringenin results in increased expression of TP63 mRNA
CTD PMID:36235125 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
JBrowse link
G TP73 tumor protein p73 increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of TP73 mRNA; naringenin results in increased expression of TP73 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of TP73 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP73 mRNA
CTD PMID:36235125 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G TPO thyroid peroxidase decreases activity ISO naringenin results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of TRAF2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TRAF2 mRNA CTD PMID:36235125 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G TSC1 TSC complex subunit 1 multiple interactions EXP [naringenin co-treated with bisphenol A] results in increased expression of TSC1 mRNA CTD PMID:36235125 NCBI chr 9:132,891,349...132,945,378
Ensembl chr 9:132,891,348...132,946,874
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions ISO naringenin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression
EXP
ISO
UGT1A1 protein results in increased glucuronidation of naringenin
naringenin results in increased expression of UGT1A1 mRNA
CTD PMID:14557274 PMID:31621310 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of naringenin CTD PMID:14557274 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of naringenin CTD PMID:14557274 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of naringenin CTD PMID:14557274 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of naringenin CTD PMID:14557274 PMID:18816295 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of naringenin; UGT2B15 protein SNP results in increased metabolism of naringenin CTD PMID:7835232 PMID:12386133 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA] CTD PMID:37076581 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WT1 WT1 transcription factor increases expression
multiple interactions
EXP naringenin metabolite results in increased expression of WT1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of WT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of WT1 mRNA
CTD PMID:36235125 NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO naringenin inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein] CTD PMID:27206700 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
G XRCC5 X-ray repair cross complementing 5 multiple interactions EXP [naringenin metabolite co-treated with bisphenol A] results in decreased expression of XRCC5 mRNA CTD PMID:36235125 NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303
JBrowse link
6-prenylnaringenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP 6-prenylnaringenin results in increased expression of CYP1A1 mRNA; 6-prenylnaringenin results in increased expression of CYP1A1 protein
6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; 6-prenylnaringenin inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA]
CTD PMID:27269377 PMID:32986415 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression EXP 6-prenylnaringenin results in increased expression of CYP1B1 mRNA CTD PMID:27269377 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP 6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]] CTD PMID:32986415 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]; 6-prenylnaringenin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein] CTD PMID:32986415 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
eriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP eriocitrin results in increased expression of BAX protein CTD PMID:34724282 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP eriocitrin results in decreased expression of BCL2 protein CTD PMID:34724282 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP7 caspase 7 increases expression EXP eriocitrin results in increased expression of CASP7 protein CTD PMID:34724282 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 increases expression EXP eriocitrin results in increased expression of CASP9 protein CTD PMID:34724282 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 decreases expression EXP eriocitrin results in decreased expression of CCND1 protein CTD PMID:34724282 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G JAK2 Janus kinase 2 decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of JAK2 protein CTD PMID:34724282 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein] CTD PMID:34724282 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP eriocitrin results in decreased expression of PCNA protein CTD PMID:34724282 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of SRC protein CTD PMID:34724282 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of STAT3 protein CTD PMID:34724282 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
hesperetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions EXP hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) multiple interactions EXP hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions EXP hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression EXP hesperetin results in decreased expression of ADIPOQ mRNA CTD PMID:25345581 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33522063 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor increases activity
multiple interactions
ISO
EXP
hesperetin results in increased activity of AHR protein
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]
CTD PMID:17869316 PMID:21720915 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:19222219 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin multiple interactions ISO hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein] CTD PMID:34922902 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 affects binding EXP hesperetin binds to ALDH4A1 protein CTD PMID:37487865 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects binding EXP hesperetin binds to APEX1 protein CTD PMID:37487865 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G ATG5 autophagy related 5 multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in decreased expression of ATG5 mRNA] CTD PMID:34933056 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression
EXP
ISO
hesperetin affects the expression of BAX protein
[Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]
hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein
hesperetin analog results in increased expression of BAX mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator affects expression
multiple interactions
decreases expression
EXP
ISO
hesperetin affects the expression of BCL2 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein
hesperetin analog results in decreased expression of BCL2 mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 PMID:37487865 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in decreased expression of BECN1 mRNA] CTD PMID:34933056 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CASP3 caspase 3 affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity
EXP
ISO
hesperetin affects the cleavage of CASP3 protein
hesperetin results in increased cleavage of CASP3 protein
hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [hesperetin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form
hesperetin analog results in increased activity of CASP3 protein
hesperetin analog results in increased expression of CASP3 mRNA
CTD PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase increases activity
multiple interactions
decreases activity
ISO
EXP
hesperetin results in increased activity of CAT protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]
CTD PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:24707119 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] CTD PMID:24707119 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions
EXP
ISO
hesperetin results in decreased expression of CCND1
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]
CTD PMID:17927510 PMID:27818223 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCS copper chaperone for superoxide dismutase affects binding EXP hesperetin binds to CCS protein CTD PMID:37487865 NCBI chr11:66,593,185...66,606,019
Ensembl chr11:66,593,153...66,606,019
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP hesperetin results in decreased expression of CDK2 CTD PMID:17927510 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions
decreases expression
EXP hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in decreased expression of CDK4
CTD PMID:17927510 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA
CTD PMID:17927510 PMID:25345581 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP hesperetin results in increased expression of CDKN1B CTD PMID:17927510 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression EXP hesperetin results in decreased expression of CEBPA protein CTD PMID:25345581 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27818223 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CSF3 colony stimulating factor 3 multiple interactions EXP hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] CTD PMID:24707119 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
JBrowse link
G CYB5A cytochrome b5 type A multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein] CTD PMID:19497424 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973
JBrowse link
G CYCS cytochrome c, somatic increases expression EXP hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein CTD PMID:22142698 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity EXP hesperetin results in decreased activity of CYP19A1 protein CTD PMID:10403137 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
EXP
ISO
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
hesperetin results in decreased activity of CYP1A1 protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:10781868 PMID:21720915 PMID:26546711 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP hesperetin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP hesperetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP hesperetin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP hesperetin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:19497424 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DAZL deleted in azoospermia like multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in decreased expression of DAZL mRNA] CTD PMID:34933056 NCBI chr 3:16,586,792...16,605,423
Ensembl chr 3:16,586,792...16,670,306
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP hesperetin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of DDIT3 protein]
CTD PMID:37487865 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein] CTD PMID:34933056 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression EXP hesperetin results in decreased expression of FABP4 mRNA CTD PMID:25345581 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:21134734 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GPX4 glutathione peroxidase 4 affects binding EXP hesperetin binds to GPX4 protein CTD PMID:37487865 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GSK3B protein] CTD PMID:34922902 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of GSR protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]
CTD PMID:21134734 PMID:26546711 PMID:35567572 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
hesperetin results in increased expression of HMOX1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
CTD PMID:15316927 PMID:31153982 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
EXP hesperetin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein]
CTD PMID:37487865 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:33522063 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions EXP hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:24707119 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:24707119 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions
affects expression
EXP
ISO
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
hesperetin affects the expression of IL1B protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions
affects expression
EXP
ISO
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]
hesperetin affects the expression of IL6 protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JAK1 Janus kinase 1 multiple interactions ISO hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein] CTD PMID:28428136 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754
JBrowse link
G JAK2 Janus kinase 2 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] CTD PMID:33522063 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G KEAP1 kelch like ECH associated protein 1 affects binding EXP hesperetin binds to KEAP1 protein CTD PMID:37487865 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LPL lipoprotein lipase decreases expression EXP hesperetin results in decreased expression of LPL mRNA CTD PMID:25345581 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:31153982 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:31153982 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
[Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]
CTD PMID:19222219 PMID:31153982 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MIR150 microRNA 150 multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR150 mRNA] CTD PMID:34933056 NCBI chr19:49,500,785...49,500,868
Ensembl chr19:49,500,785...49,500,868
JBrowse link
G MIR181B2 microRNA 181b-2 multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR181B2 mRNA] CTD PMID:34933056 NCBI chr 9:124,693,710...124,693,798
Ensembl chr 9:124,693,710...124,693,798
JBrowse link
G MIR410 microRNA 410 multiple interactions ISO hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:32762101 NCBI chr14:101,065,912...101,065,991
Ensembl chr14:101,065,912...101,065,991
JBrowse link
G MPO myeloperoxidase multiple interactions ISO hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:31153982 PMID:33522063 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR protein] CTD PMID:34933056 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein] CTD PMID:27818223 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO
EXP
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
hesperetin results in increased expression of NFE2L2 protein
[Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein
CTD PMID:26546711 PMID:31153982 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]
CTD PMID:12512693 PMID:15316927 PMID:35567572 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX4 NADPH oxidase 4 decreases expression
multiple interactions
EXP
ISO
hesperetin results in decreased expression of NOX4 protein
hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]
CTD PMID:31153982 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO
EXP
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein]
hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]
hesperetin results in increased expression of NQO1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein
CTD PMID:19497424 PMID:31153982 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 affects binding EXP hesperetin binds to NQO2 protein CTD PMID:37487865 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP hesperetin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of PCNA mRNA]
CTD PMID:26546711 PMID:34933056 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDCD6IP programmed cell death 6 interacting protein multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [hesperetin results in decreased expression of PDCD6IP protein] CTD PMID:37487865 NCBI chr 3:33,798,630...33,869,703
Ensembl chr 3:33,798,571...33,869,707
JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:19497424 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression
multiple interactions
EXP
ISO
hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein]
CTD PMID:25345581 PMID:28428136 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions ISO hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects activity
ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
hesperetin affects the activity of PTGS2 protein
CTD PMID:15240993 PMID:16101151 PMID:35567572 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]
CTD PMID:26546711 PMID:35567572 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RETN resistin decreases expression EXP hesperetin results in decreased expression of RETN mRNA CTD PMID:25345581 NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455
JBrowse link
G SHBG sex hormone binding globulin affects binding EXP hesperetin binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G SIRT3 sirtuin 3 affects binding EXP hesperetin binds to SIRT3 protein CTD PMID:37487865 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SIRT6 sirtuin 6 multiple interactions
increases expression
EXP [Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein
hesperetin results in increased expression of SIRT6 protein
CTD PMID:31153982 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] CTD PMID:33522063 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO hesperetin results in increased expression of SOD1 protein CTD PMID:19023542 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression ISO hesperetin results in increased expression of SOD2 protein CTD PMID:19023542 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX18 SRY-box transcription factor 18 multiple interactions ISO hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]] CTD PMID:32762101 NCBI chr20:64,047,582...64,049,639
Ensembl chr20:64,047,582...64,049,639
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein] CTD PMID:28428136 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:33522063 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 PMID:34922902 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions
affects expression
decreases expression
ISO
EXP
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
hesperetin affects the expression of TNF protein
hesperetin results in decreased expression of TNF mRNA
CTD PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [hesperetin results in increased expression of TP53 protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] CTD PMID:15795422 PMID:37487865 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 affects binding EXP hesperetin binds to UQCRFS1 protein CTD PMID:37487865 NCBI chr19:29,205,320...29,213,151
Ensembl chr19:29,205,320...29,213,151
JBrowse link
G UTRN utrophin increases expression EXP hesperetin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 6:144,285,335...144,853,034
Ensembl chr 6:144,285,335...144,853,034
JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO [2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AFP alpha fetoprotein multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of AKT1 protein] CTD PMID:30779474 PMID:35413380 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT2 AKT serine/threonine kinase 2 increases expression
multiple interactions
ISO Hesperidin results in increased expression of AKT2 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]
CTD PMID:36966900 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALB albumin multiple interactions
increases expression
ISO [Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein
CTD PMID:29481770 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ATF6 mRNA]
Hesperidin results in decreased expression of ATF6 mRNA
CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Hesperidin results in increased expression of BAX mRNA
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]
CTD PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO [Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]
CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BECN1 protein]
Hesperidin results in decreased expression of BECN1 protein
CTD PMID:33908150 PMID:34748272 PMID:35413380 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BMP2 bone morphogenetic protein 2 increases expression ISO Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
increases expression
increases activity
ISO [Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
Hesperidin results in decreased expression of CASP3 protein
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein
CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
increases activity
ISO Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Finasteride results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]
Hesperidin results in decreased activity of CAT protein
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]
CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 protein]
Hesperidin results in decreased expression of CCND1 mRNA; Hesperidin results in decreased expression of CCND1 protein
CTD PMID:34984768 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression
multiple interactions
EXP Hesperidin results in decreased expression of CDK4 mRNA; Hesperidin results in decreased expression of CDK4 protein
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 protein]
CTD PMID:34984768 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 multiple interactions
decreases expression
EXP BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 protein]
Hesperidin results in decreased expression of CDK6 mRNA; Hesperidin results in decreased expression of CDK6 protein
CTD PMID:34984768 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A protein]
Hesperidin results in increased expression of CDKN1A mRNA; Hesperidin results in increased expression of CDKN1A protein
CTD PMID:34984768 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
multiple interactions
EXP Hesperidin results in increased expression of CDKN1B mRNA; Hesperidin results in increased expression of CDKN1B protein
BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B protein]
CTD PMID:34984768 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein] CTD PMID:17400256 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression
ISO Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA]
Hesperidin results in increased expression of EIF2AK3 mRNA
CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA] CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
JBrowse link
G FABP9 fatty acid binding protein 9 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 8:81,458,253...81,461,579
Ensembl chr 8:81,458,253...81,461,579
JBrowse link
G FASN fatty acid synthase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G G6PC3 glucose-6-phosphatase catalytic subunit 3 multiple interactions ISO Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr17:44,070,673...44,076,344
Ensembl chr17:44,070,620...44,082,151
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases activity
multiple interactions
EXP
ISO
Hesperidin results in decreased activity of G6PD protein
Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]
CTD PMID:16427799 PMID:25130191 PMID:31345080 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GCK glucokinase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions
decreases activity
ISO [Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]
Hesperidin results in decreased activity of GPT protein
CTD PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions EXP Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA] CTD PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA] CTD PMID:34748272 PMID:35413380 PMID:36966900 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 PMID:35413380 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions ISO Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
CTD PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JAK2 Janus kinase 2 multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA] CTD PMID:34748272 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G LEP leptin decreases expression
multiple interactions
ISO Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein
CTD PMID:21820093 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3A protein] CTD PMID:34748272 PMID:35413380 PMID:35921949 NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3B protein] CTD PMID:34748272 PMID:35413380 PMID:35921949 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 decreases phosphorylation EXP Hesperidin results in decreased phosphorylation of MAP2K5 protein CTD PMID:34984768 NCBI chr15:67,542,703...67,807,114
Ensembl chr15:67,542,703...67,807,117
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA] CTD PMID:33908150 PMID:34748272 PMID:35921949 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 multiple interactions EXP BIX 02189 promotes the reaction [Hesperidin results in decreased phosphorylation of MAPK7 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased phosphorylation of MAPK7 protein]; Hesperidin results in decreased phosphorylation of and affects the localization of MAPK7 protein CTD PMID:34984768 NCBI chr17:19,377,750...19,383,544
Ensembl chr17:19,377,721...19,383,544
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MIR181A2 microRNA 181a-2 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 9:124,692,442...124,692,551
Ensembl chr 9:124,692,442...124,692,551
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA] CTD PMID:35921949 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases secretion
EXP
ISO
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein
CTD PMID:19110045 PMID:20138977 PMID:35921949 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase decreases activity
multiple interactions
ISO Hesperidin results in decreased activity of MPO protein
Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
CTD PMID:31095933 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of MTOR protein] CTD PMID:35413380 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA]
Hesperidin results in increased expression of NFE2L2 mRNA
CTD PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]
Hesperidin results in increased expression of NFKB1 mRNA
CTD PMID:22093918 PMID:34748272 PMID:35921949 PMID:36966900 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein]
CTD PMID:12512693 PMID:22093918 PMID:33908150 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 PMID:33908150 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]
CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]
CTD PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SGPP2 sphingosine-1-phosphate phosphatase 2 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 2:222,423,988...222,562,621
Ensembl chr 2:222,424,543...222,562,621
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC1A2 solute carrier family 1 member 2 multiple interactions EXP Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] CTD PMID:34800614 NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPHK1 sphingosine kinase 1 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA] CTD PMID:34748272 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TFEB transcription factor EB multiple interactions ISO Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259
JBrowse link
G TNC tenascin C multiple interactions ISO Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of TNF mRNA
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF25 TNF receptor superfamily member 25 increases expression EXP Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 1:6,460,786...6,466,173
Ensembl chr 1:6,460,786...6,466,175
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] CTD PMID:30066062 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression EXP Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1
CTD PMID:17400256 PMID:30991044 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO [Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein CTD PMID:33908150 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G YY1 YY1 transcription factor multiple interactions EXP Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein] CTD PMID:34800614 NCBI chr14:100,239,144...100,282,788
Ensembl chr14:100,238,298...100,282,788
JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
homoeriodictyol results in increased expression of NQO1 mRNA
CTD PMID:29902531 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
ISO
EXP
kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
ISO
EXP
kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCND1 cyclin D1 decreases expression EXP
ISO
kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP
ISO
kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
EXP
ISO
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
naringenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression EXP Naringenin increases expression of NR1H3 mRNA and protein in macrophages RGD PMID:29140707 RGD:401842389 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
naringin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO [naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA CTD PMID:22198281 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACE angiotensin I converting enzyme multiple interactions ISO naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein] CTD PMID:32172062 PMID:32810514 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22198281 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression
ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein]
naringin results in decreased expression of ACP5 mRNA
CTD PMID:21835177 PMID:24376342 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993
JBrowse link
G ADA adenosine deaminase multiple interactions ISO naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:22198281 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGT angiotensinogen multiple interactions EXP naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22798349 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 multiple interactions ISO naringin inhibits the reaction [Acetaminophen results in decreased expression of AKR7A5 protein] CTD PMID:35166444 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA]
CTD PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ANGPT1 angiopoietin 1 affects expression ISO naringin affects the expression of ANGPT1 mRNA CTD PMID:24880026 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AQP5 aquaporin 5 multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:21835177 NCBI chr 8:86,098,910...86,154,225
Ensembl chr 8:85,987,323...86,154,225
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions ISO naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA]
naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]
CTD PMID:21945202 PMID:30878453 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
naringin results in increased expression of BAX mRNA
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]
naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]
CTD PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] CTD PMID:32172062 PMID:32810514 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]
naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]
CTD PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 PMID:35166444 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression
increases secretion
multiple interactions
EXP
ISO
naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein
naringin results in increased secretion of BGLAP protein
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]
CTD PMID:18495116 PMID:21741227 PMID:23596885 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BMP2 bone morphogenetic protein 2 multiple interactions
decreases expression
increases secretion
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]
naringin results in decreased expression of BMP2 mRNA
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein
CTD PMID:18495116 PMID:21820093 PMID:23596885 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP3 bone morphogenetic protein 3 decreases expression ISO naringin results in decreased expression of BMP3 mRNA CTD PMID:18495116 NCBI chr 4:81,030,708...81,057,627
Ensembl chr 4:81,030,708...81,057,627
JBrowse link
G BMP4 bone morphogenetic protein 4 increases expression EXP naringin results in increased expression of BMP4 mRNA CTD PMID:24915843 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G CALCR calcitonin receptor multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA] CTD PMID:21835177 NCBI chr 7:93,424,486...93,574,724
Ensembl chr 7:93,424,486...93,574,730
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP
ISO
naringin results in increased expression of CASP3 mRNA
naringin inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein modified form]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CASP3 protein]
naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]
CTD PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 increases expression
multiple interactions
EXP
ISO
naringin results in increased expression of CASP9 mRNA
[bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]
CTD PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]
CTD PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA]
CTD PMID:22965302 PMID:33992719 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:22965302 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein] CTD PMID:21500970 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions
increases expression
EXP
ISO
naringin results in decreased expression of CCND1 protein
naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA]
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein]
naringin results in increased expression of CCND1 mRNA
CTD PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP
ISO
naringin results in decreased expression of CCNE1 protein CTD PMID:18296682 PMID:18951945 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein
CTD PMID:18296682 PMID:18951945 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]
CTD PMID:18296682 PMID:18951945 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
CTD PMID:18296682 PMID:18951945 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions ISO naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 multiple interactions ISO CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of CHAC2 protein] CTD PMID:35166444 PMID:35179299 NCBI chr 2:53,767,783...53,775,196
Ensembl chr 2:53,767,804...53,775,196
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression ISO naringin results in increased expression of COL1A1 mRNA CTD PMID:21741227 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO [Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA CTD PMID:22198281 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA] CTD PMID:21835177 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CTNNB1 catenin beta 1 increases expression
multiple interactions
EXP naringin results in increased expression of CTNNB1 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein]
CTD PMID:24915843 PMID:26482937 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] CTD PMID:17188415 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CTSD cathepsin D multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSK cathepsin K multiple interactions
decreases expression
ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]
naringin results in decreased expression of CTSK mRNA
CTD PMID:21835177 PMID:24376342 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression ISO naringin results in increased expression of CXCL12 protein CTD PMID:29510123 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 affects expression ISO naringin affects the expression of CXCL2 mRNA CTD PMID:25117567 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions ISO naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL15 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL15 protein] CTD PMID:22965302 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression ISO naringin results in increased expression of CXCR4 protein CTD PMID:29510123 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions EXP naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein] CTD PMID:25391245 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein] CTD PMID:28422390 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 multiple interactions EXP naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA] CTD PMID:22798349 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO naringin inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA] CTD PMID:36598108 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP naringin results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP naringin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP naringin binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP naringin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] CTD PMID:21053930 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases activity
EXP naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]
naringin results in decreased activity of CYP3A4 protein
CTD PMID:16013069 PMID:21053930 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DHFR dihydrofolate reductase decreases activity EXP naringin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions EXP DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]] CTD PMID:26482937 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
JBrowse link
G EGF epidermal growth factor multiple interactions EXP naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein] CTD PMID:22766066 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein] CTD PMID:22766066 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA] CTD PMID:23596885 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA] CTD PMID:23596885 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] CTD PMID:22198281 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FADD Fas associated via death domain increases expression EXP naringin results in increased expression of FADD mRNA CTD PMID:22847135 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP naringin results in increased expression of FAS mRNA CTD PMID:22847135 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASN fatty acid synthase multiple interactions ISO naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:16427799 PMID:22198281 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA] CTD PMID:23596885 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]
naringin results in increased expression of FOS mRNA
CTD PMID:18495116 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO naringin inhibits the reaction [Acrylamide results in decreased expression of FSHB protein] CTD PMID:36598108 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA] CTD PMID:16427799 PMID:22198281 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]
naringin affects the reaction [LEPR protein affects the activity of G6PD protein]
CTD PMID:16427799 PMID:20950607 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GAL galanin and GMAP prepropeptide multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:17188415 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GCK glucokinase multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]; rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
naringin results in increased expression of GCLC mRNA; naringin results in increased expression of GCLC protein
CTD PMID:22871521 PMID:25773745 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO naringin inhibits the reaction [Acetaminophen results in increased secretion of GOT1 protein] CTD PMID:35166444 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
naringin inhibits the reaction [Acetaminophen results in increased secretion of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]
CTD PMID:27174133 PMID:33992719 PMID:35166444 PMID:36811345 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 increases activity ISO naringin results in increased activity of GPX1 protein CTD PMID:23603004 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO
EXP
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]
naringin inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein]
CTD PMID:20950607 PMID:21945202 PMID:23650045 PMID:33992719 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO naringin results in increased expression of GSTP1 mRNA
[naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA
CTD PMID:22871521 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:17188415 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]
CTD PMID:16427799 PMID:16906524 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
increases activity
ISO CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]
naringin results in increased expression of HMOX1 mRNA; naringin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; naringin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
naringin results in increased activity of HMOX1 protein
CTD PMID:22871521 PMID:23603004 PMID:25773745 PMID:27174133 PMID:35166444 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions
increases activity
EXP
ISO
HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of HRAS protein
CTD PMID:18296682 PMID:18951945 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
affects expression
EXP
ISO
naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]
naringin affects the expression of ICAM1 mRNA
CTD PMID:22074828 PMID:25117567 PMID:25391245 PMID:35166444 PMID:35179299 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNA1 interferon alpha 1 multiple interactions ISO naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA] CTD PMID:33992719 NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316
JBrowse link
G IFNG interferon gamma multiple interactions
affects expression
EXP
ISO
naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]
naringin affects the expression of IFNG mRNA
CTD PMID:16945185 PMID:21500970 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 affects expression
multiple interactions
increases expression
ISO naringin affects the expression of IGF1 mRNA
naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]
naringin results in increased expression of IGF1 mRNA
fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]
CTD PMID:23596885 PMID:24880026 PMID:30878453 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL10 interleukin 10 multiple interactions
affects expression
ISO naringin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 protein]
naringin affects the expression of IL10 protein
CTD PMID:22985397 PMID:25117567 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta affects expression
multiple interactions
ISO
EXP
naringin affects the expression of IL1B mRNA
[bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; naringin inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]
CTD PMID:24131540 PMID:24880026 PMID:30130594 PMID:32172062 PMID:32428650 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1R1 interleukin 1 receptor type 1 multiple interactions ISO naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA] CTD PMID:33992719 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G IL2 interleukin 2 affects expression ISO naringin affects the expression of IL2 protein CTD PMID:25117567 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 affects expression ISO naringin affects the expression of IL4 protein CTD PMID:25117567 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 affects expression
decreases expression
multiple interactions
ISO
EXP
naringin affects the expression of IL6 mRNA
naringin results in decreased expression of IL6 protein
naringin affects the expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 protein]
CTD PMID:16137700 PMID:19810018 PMID:21820093 PMID:24131540 PMID:24880026 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough affects expression
multiple interactions
ISO naringin affects the expression of INS1 protein
naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]
CTD PMID:24880026 PMID:29658312 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] CTD PMID:22198281 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]
naringin results in increased expression of JUN mRNA
CTD PMID:18495116 PMID:35166444 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:36811345 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LCAT lecithin-cholesterol acyltransferase multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16906524 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] CTD PMID:17188415 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G LDHB lactate dehydrogenase B multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] CTD PMID:17188415 NCBI chr12:21,635,342...21,657,842
Ensembl chr12:21,635,342...21,757,857
JBrowse link
G LEP leptin multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein; naringin inhibits the reaction [Glucose results in increased expression of LEP protein]
CTD PMID:21820093 PMID:22198281 PMID:24399619 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor multiple interactions ISO naringin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin affects the reaction [LEPR protein affects the activity of G6PD protein]; naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]; naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]; naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]
naringin inhibits the reaction [Glucose results in increased expression of LEPR protein]
CTD PMID:16427799 PMID:24399619 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO naringin inhibits the reaction [Acrylamide results in decreased expression of LHB protein] CTD PMID:36598108 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G LPL lipoprotein lipase multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein] CTD PMID:16906524 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAOA monoamine oxidase A multiple interactions ISO [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of MAOA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More... NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK10 mitogen-activated protein kinase 10 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK10 protein] CTD PMID:22198281 NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO naringin inhibits the reaction [Acrylamide results in increased expression of MAPK14 mRNA] CTD PMID:36598108 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More... NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein] CTD PMID:22198281 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein] CTD PMID:22198281 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MIR126 microRNA 126 increases expression
multiple interactions
EXP naringin results in increased expression of MIR126 mRNA
MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]
CTD PMID:24975661 NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP naringin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26721195 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO
EXP
naringin inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
naringin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringin results in decreased expression of and results in decreased activity of MMP9 protein
naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]
CTD PMID:19810018 PMID:22985397 PMID:23603004 PMID:25866363 PMID:26721195 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO naringin inhibits the reaction [Tobacco Smoke Pollution results in increased activity of MPO protein] CTD PMID:22985397 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT3 metallothionein 3 multiple interactions EXP naringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein] CTD PMID:28422390 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein] CTD PMID:19810018 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP
ISO
naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]
CTD PMID:22766066 PMID:31301536 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
CTD PMID:22871521 PMID:25773745 PMID:27174133 PMID:35166444 PMID:35179299 More... NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO naringin inhibits the reaction [Cisplatin results in increased expression of NFKB1 mRNA] CTD PMID:26120027 PMID:26612654 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha affects degradation
multiple interactions
ISO naringin affects the degradation of NFKBIA protein
naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]
CTD PMID:21835177 PMID:25117567 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 affects expression
multiple interactions
ISO naringin affects the expression of NOS2 mRNA
naringin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]
CTD PMID:16137700 PMID:22871521 PMID:25117567 PMID:26612654 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions EXP naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein] CTD PMID:25391245 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA
naringin results in increased expression of NQO1 mRNA
CTD PMID:22871521 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OGDH oxoglutarate dehydrogenase multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:17994577 NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA] CTD PMID:16427799 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PDE5A phosphodiesterase 5A multiple interactions ISO naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3CA mRNA] CTD PMID:30878453 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:30878453 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22198281 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]
CTD PMID:16427799 PMID:22198281 PMID:30130594 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO naringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA] CTD PMID:18793633 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKCD protein kinase C delta increases phosphorylation
multiple interactions
ISO naringin results in increased phosphorylation of PRKCD protein
rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]
CTD PMID:25773745 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions
ISO naringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 protein
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]
naringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD PMID:16137700 PMID:22871521 PMID:25117567 PMID:35166444 PMID:35179299 More... NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases activity
increases phosphorylation
EXP
ISO
RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of RAF1 protein
naringin results in increased phosphorylation of RAF1 protein
CTD PMID:18296682 PMID:18951945 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein affects the localization of RELA protein]
naringin affects the expression of and affects the activity of RELA protein; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
CTD PMID:21500970 PMID:22766066 PMID:22965302 PMID:25117567 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions ISO naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15342961 PMID:19810018 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO
EXP
naringin results in increased expression of RUNX2 mRNA
naringin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA]
CTD PMID:21741227 PMID:23596885 PMID:24915843 PMID:26482937 PMID:30878453 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]
naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
CTD PMID:18793633 PMID:36811345 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine] CTD PMID:24947867 PMID:25466967 PMID:27504015 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP naringin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 PMID:22394605 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]] CTD PMID:21345335 PMID:35166444 PMID:35179299 PMID:36811345 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP7 Sp7 transcription factor increases expression
multiple interactions
ISO
EXP
naringin results in increased expression of SP7 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA]
CTD PMID:23596885 PMID:26482937 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPN sialophorin multiple interactions
increases expression
decreases expression
ISO [bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]
naringin results in increased expression of SPN protein
naringin results in decreased expression of SPN protein
CTD PMID:32172062 PMID:32428650 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression
increases secretion
multiple interactions
ISO
EXP
naringin results in increased expression of SPP1 mRNA; naringin results in increased expression of SPP1 protein
naringin results in increased secretion of SPP1 protein
fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein]
CTD PMID:18495116 PMID:23596885 PMID:24915843 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22198281 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO naringin inhibits the reaction [Acrylamide results in decreased expression of STAR mRNA] CTD PMID:36598108 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STAT3 signal transducer and activator of transcription 3 affects expression ISO naringin affects the expression of STAT3 mRNA; naringin affects the expression of STAT3 protein CTD PMID:25117567 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
affects expression
ISO naringin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of TGFB1 mRNA]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]
naringin affects the expression of TGFB1 mRNA
CTD PMID:23603004 PMID:25117567 PMID:27174133 PMID:33992719 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 protein] CTD PMID:23603004 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions
affects expression
ISO
EXP
naringin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
naringin affects the expression of TNF protein
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin affects the expression of TNF mRNA
CTD PMID:16137700 PMID:19810018 PMID:21500970 PMID:22198281 PMID:22871521 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a decreases expression ISO naringin results in decreased expression of TNFRSF11A mRNA CTD PMID:24376342 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions ISO naringin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of TNFRSF11B protein] CTD PMID:30878453 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]; naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:21835177 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TNNT2 troponin T2, cardiac type multiple interactions ISO naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:17188415 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
decreases expression
EXP
ISO
naringin results in increased expression of TP53 mRNA
naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
naringin results in decreased expression of TP53 protein
[bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TP53 mRNA]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]
CTD PMID:22847135 PMID:26120027 PMID:26612654 PMID:32172062 PMID:32428650 More... NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions EXP naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein] CTD PMID:24131540 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA] CTD PMID:22198281 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin results in decreased expression of VCAM1 mRNA; naringin results in decreased expression of VCAM1 protein
CTD PMID:24975661 PMID:25391245 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VEGFC vascular endothelial growth factor C affects expression ISO naringin affects the expression of VEGFC mRNA CTD PMID:24880026 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
neoeriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGLAP bone gamma-carboxyglutamate protein multiple interactions
increases expression
ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA
CTD PMID:21741227 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA
CTD PMID:21741227 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO neoeriocitrin results in increased expression of RUNX2 mRNA CTD PMID:21741227 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
sophoraflavanone B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions
increases activity
increases expression
EXP [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
8-prenylnaringenin results in increased activity of ALPL protein
8-prenylnaringenin results in increased expression of ALPL mRNA
CTD PMID:12650720 PMID:16019205 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G C3 complement C3 increases expression ISO 8-prenylnaringenin results in increased expression of C3 mRNA CTD PMID:16522720 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CBR1 carbonyl reductase 1 multiple interactions EXP 8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; 8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CGA glycoprotein hormones, alpha polypeptide decreases expression ISO 8-prenylnaringenin results in decreased expression of CGA mRNA CTD PMID:16522720 NCBI chr 6:87,085,498...87,095,106
Ensembl chr 6:87,085,498...87,095,106
JBrowse link
G CSN2 casein beta increases expression
multiple interactions
ISO 8-prenylnaringenin results in increased expression of CSN2 mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of CSN2 mRNA]
CTD PMID:26372666 NCBI chr 4:69,955,256...69,965,728
Ensembl chr 4:69,955,256...69,965,728
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
decreases expression
EXP 8-prenylnaringenin results in decreased activity of CYP1A1 protein
8-prenylnaringenin results in decreased expression of CYP1A1 mRNA
CTD PMID:19770484 PMID:32986415 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases expression
EXP 8-prenylnaringenin results in decreased activity of CYP1A2 protein
8-prenylnaringenin results in increased expression of CYP1A2 mRNA
CTD PMID:15672752 PMID:19770484 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP 8-prenylnaringenin results in decreased activity of CYP3A4 protein CTD PMID:19770484 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
increases expression
increases activity
EXP
ISO
8-prenylnaringenin analog binds to and results in increased activity of ESR1 protein; 8-prenylnaringenin binds to and results in increased activity of ESR1 protein; [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]
8-prenylnaringenin results in increased expression of ESR1 mRNA
8-prenylnaringenin results in increased activity of ESR1 protein
CTD PMID:12623674 PMID:12650720 PMID:15876408 PMID:16076101 PMID:17149865 More... NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 decreases expression
increases expression
multiple interactions
increases activity
ISO
EXP
8-prenylnaringenin results in decreased expression of ESR2 mRNA
8-prenylnaringenin results in increased expression of ESR2 mRNA
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR2 mRNA
8-prenylnaringenin analog binds to and results in decreased activity of ESR2 protein; 8-prenylnaringenin binds to and results in increased activity of ESR2 protein
8-prenylnaringenin results in increased activity of ESR2 protein
CTD PMID:16076101 PMID:16522720 PMID:17149865 PMID:17716812 PMID:34848279 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression ISO 8-prenylnaringenin results in decreased expression of FSHB protein CTD PMID:16522720 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G GNRHR gonadotropin releasing hormone receptor decreases expression ISO 8-prenylnaringenin results in decreased expression of GNRHR mRNA CTD PMID:16522720 NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO [Fulvestrant co-treated with 8-prenylnaringenin] results in decreased expression of IGF1 mRNA CTD PMID:34848279 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor increases expression ISO 8-prenylnaringenin results in increased expression of IGF1R mRNA CTD PMID:16522720 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL6 interleukin 6 decreases expression EXP 8-prenylnaringenin results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KIF11 kinesin family member 11 multiple interactions
increases expression
ISO Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA] CTD PMID:26372666 NCBI chr10:92,593,130...92,655,395
Ensembl chr10:92,574,105...92,655,395
JBrowse link
G KIF18A kinesin family member 18A increases expression
multiple interactions
ISO 8-prenylnaringenin results in increased expression of KIF18A mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF18A mRNA]
CTD PMID:26372666 NCBI chr11:28,020,619...28,108,156
Ensembl chr11:28,020,619...28,108,156
JBrowse link
G KIF2C kinesin family member 2C increases expression ISO 8-prenylnaringenin results in increased expression of KIF2C mRNA CTD PMID:26372666 NCBI chr 1:44,739,837...44,767,767
Ensembl chr 1:44,739,818...44,767,767
JBrowse link
G LHB luteinizing hormone subunit beta decreases expression ISO 8-prenylnaringenin results in decreased expression of LHB mRNA; 8-prenylnaringenin results in decreased expression of LHB protein CTD PMID:16522720 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression ISO 8-prenylnaringenin results in decreased expression of MKI67 mRNA CTD PMID:26372666 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G PGR progesterone receptor increases expression
multiple interactions
EXP
ISO
8-prenylnaringenin results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [8-prenylnaringenin results in increased expression of PGR mRNA]
8-prenylnaringenin results in increased expression of PGR mRNA; 8-prenylnaringenin results in increased expression of PGR protein
CTD PMID:16076101 PMID:16522720 PMID:16837889 PMID:34848279 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PRL prolactin increases expression ISO 8-prenylnaringenin results in increased expression of PRL protein CTD PMID:16522720 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G TFF1 trefoil factor 1 increases expression EXP 8-prenylnaringenin results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535
JBrowse link
G VWF von Willebrand factor increases expression EXP 8-prenylnaringenin results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      molecular entity 25997
        polyatomic entity 25882
          heteroatomic molecular entity 25533
            hydroxides 24051
              organic hydroxy compound 22058
                hydroxyflavanone 557
                  trihydroxyflavanone 380
                    (-)-(2S)-5,7,2'-trihydroxy-5'-(1''',1'''-dimethylallyl)-8-prenylflavanone 0
                    (-)-(2S)-5,7,2'-trihydroxy-8,3'-diprenylflavanone 0
                    (2S)-(-)-kurarinone + 0
                    (2S)-2'-hydroxydemethoxymatteucinol 0
                    (2S)-5,7,3',5'-tetrahydroxyflavanone-7-O-beta-D-glucopyranoside 0
                    (2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone 0
                    (2S)-carthamidin-7-methyl ether 0
                    (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                    (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                    (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                    2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one + 0
                    5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                    5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                    6,7,4'-trihydroxyflavanone 0
                    6,8-diprenylnaringenin 0
                    6-methoxyaromadendrin 3-O-acetate 0
                    6-prenylnaringenin 4
                    abyssinone V 0
                    butin + 0
                    eriocitrin 10
                    eriodictyol 7-O-beta-D-glucopyranoside 0
                    eriosemaone C 0
                    euchrenone-a7 0
                    exiguaflavanone B 0
                    fustin 3-O-beta-D-galactoside 0
                    garbanzol 0
                    glepidotin B 0
                    guangsangon M 0
                    guangsangon N 0
                    hesperetin + 144
                    homoeriodictyol + 21
                    isohemiphloin 0
                    kurarinol 5
                    leachianone A 0
                    lespeflorin B2 0
                    lespeflorin B3 0
                    macaflavanone G 0
                    monotesone A 0
                    myrciacitrin I 0
                    myrciacitrin III 0
                    myrciacitrin IV 0
                    myrciacitrin V 0
                    naringenin + 321
                    neocarthamin 0
                    neoeriocitrin 3
                    phellamurin 0
                    pinobanksin 0
                    pisonivanone 0
                    remangiflavanone A 0
                    schizolaenone A 0
                    sophoraflavanone A 0
                    sophoraflavanone B 24
                    sophoraflavanone L 0
                    tanariflavanone B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24279
                                organic heterocyclic compound 22322
                                  oxacycle 19968
                                    benzopyran 12540
                                      1-benzopyran 12268
                                        flavonoid 7285
                                          flavans 3491
                                            flavanones 570
                                              hydroxyflavanone 557
                                                trihydroxyflavanone 380
                                                  (-)-(2S)-5,7,2'-trihydroxy-5'-(1''',1'''-dimethylallyl)-8-prenylflavanone 0
                                                  (-)-(2S)-5,7,2'-trihydroxy-8,3'-diprenylflavanone 0
                                                  (2S)-(-)-kurarinone + 0
                                                  (2S)-2'-hydroxydemethoxymatteucinol 0
                                                  (2S)-5,7,3',5'-tetrahydroxyflavanone-7-O-beta-D-glucopyranoside 0
                                                  (2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone 0
                                                  (2S)-carthamidin-7-methyl ether 0
                                                  (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                                                  (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                                                  (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                                                  2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one + 0
                                                  5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  6,7,4'-trihydroxyflavanone 0
                                                  6,8-diprenylnaringenin 0
                                                  6-methoxyaromadendrin 3-O-acetate 0
                                                  6-prenylnaringenin 4
                                                  abyssinone V 0
                                                  butin + 0
                                                  eriocitrin 10
                                                  eriodictyol 7-O-beta-D-glucopyranoside 0
                                                  eriosemaone C 0
                                                  euchrenone-a7 0
                                                  exiguaflavanone B 0
                                                  fustin 3-O-beta-D-galactoside 0
                                                  garbanzol 0
                                                  glepidotin B 0
                                                  guangsangon M 0
                                                  guangsangon N 0
                                                  hesperetin + 144
                                                  homoeriodictyol + 21
                                                  isohemiphloin 0
                                                  kurarinol 5
                                                  leachianone A 0
                                                  lespeflorin B2 0
                                                  lespeflorin B3 0
                                                  macaflavanone G 0
                                                  monotesone A 0
                                                  myrciacitrin I 0
                                                  myrciacitrin III 0
                                                  myrciacitrin IV 0
                                                  myrciacitrin V 0
                                                  naringenin + 321
                                                  neocarthamin 0
                                                  neoeriocitrin 3
                                                  phellamurin 0
                                                  pinobanksin 0
                                                  pisonivanone 0
                                                  remangiflavanone A 0
                                                  schizolaenone A 0
                                                  sophoraflavanone A 0
                                                  sophoraflavanone B 24
                                                  sophoraflavanone L 0
                                                  tanariflavanone B 0
paths to the root