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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethoxyflavanone
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Accession:CHEBI:38738 term browser browse the term
Definition:Any methoxyflavanone that is flavanone substituted by a methoxy group.
Synonyms:related_synonym: monomethoxyflavanones


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hesperetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions ISO hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions ISO hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 multiple interactions ISO hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO hesperetin results in decreased expression of ADIPOQ mRNA CTD PMID:25345581 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33522063 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity
multiple interactions
EXP
ISO
hesperetin results in increased activity of AHR protein
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]
CTD PMID:17869316 PMID:21720915 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:19222219 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bax BCL2-associated X protein affects expression
multiple interactions
increases expression
ISO
EXP
hesperetin affects the expression of BAX protein
[Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]
hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein
hesperetin analog results in increased expression of BAX mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects expression
multiple interactions
decreases expression
ISO
EXP
hesperetin affects the expression of BCL2 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein
hesperetin analog results in decreased expression of BCL2 mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 affects cleavage
multiple interactions
increases expression
increases activity
ISO
EXP
hesperetin affects the cleavage of CASP3 protein
hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form
hesperetin analog results in increased activity of CASP3 protein
hesperetin analog results in increased expression of CASP3 mRNA
CTD PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
EXP
ISO
hesperetin results in increased activity of CAT protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]
CTD PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 PMID:26546711 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:24707119 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] CTD PMID:24707119 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO hesperetin results in decreased expression of CCND1
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]
CTD PMID:17927510 PMID:27818223 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO hesperetin results in decreased expression of CDK2 CTD PMID:17927510 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in decreased expression of CDK4
CTD PMID:17927510 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA
CTD PMID:17927510 PMID:25345581 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO hesperetin results in increased expression of CDKN1B CTD PMID:17927510 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression ISO hesperetin results in decreased expression of CEBPA protein CTD PMID:25345581 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27818223 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] CTD PMID:24707119 NCBI chr11:98,700,183...98,703,631
Ensembl chr11:98,701,263...98,703,629
JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein] CTD PMID:19497424 NCBI chr18:84,851,338...84,879,871
Ensembl chr18:84,838,704...84,879,871
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein CTD PMID:22142698 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO hesperetin results in decreased activity of CYP19A1 protein CTD PMID:10403137 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO
EXP
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
hesperetin results in decreased activity of CYP1A1 protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:10781868 PMID:21720915 PMID:26546711 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO hesperetin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO hesperetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO hesperetin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO hesperetin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO hesperetin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:19497424 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression ISO hesperetin results in decreased expression of FABP4 mRNA CTD PMID:25345581 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:21134734 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP
hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]
CTD PMID:21134734 PMID:26546711 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
hesperetin results in increased expression of HMOX1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
CTD PMID:15316927 PMID:31153982 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:33522063 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:24707119 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:24707119 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
ISO
EXP
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
hesperetin affects the expression of IL1B protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions
affects expression
ISO
EXP
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]
hesperetin affects the expression of IL6 protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein] CTD PMID:28428136 NCBI chr 4:101,151,974...101,265,282
Ensembl chr 4:101,152,367...101,265,282
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] CTD PMID:33522063 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO hesperetin results in decreased expression of LPL mRNA CTD PMID:25345581 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:31153982 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:31153982 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
[Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]
CTD PMID:19222219 PMID:31153982 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mir410 microRNA 410 multiple interactions EXP hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:32762101 NCBI chr12:109,743,715...109,743,795
Ensembl chr12:109,743,715...109,743,795
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO
hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:31153982 PMID:33522063 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein] CTD PMID:27818223 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
EXP
ISO
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
hesperetin results in increased expression of NFE2L2 protein
[Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein
CTD PMID:26546711 PMID:31153982 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:12512693 PMID:15316927 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases expression
ISO
EXP
hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]
hesperetin results in decreased expression of NOX4 protein
CTD PMID:31153982 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO
EXP
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein]
hesperetin results in increased expression of NQO1 protein
hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein
CTD PMID:19497424 PMID:31153982 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO hesperetin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein] CTD PMID:26546711 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:19497424 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
multiple interactions
ISO
EXP
hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein]
CTD PMID:25345581 PMID:28428136 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects activity
EXP
ISO
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
hesperetin affects the activity of PTGS2 protein
CTD PMID:15240993 PMID:16101151 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:26546711 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Retn resistin decreases expression ISO hesperetin results in decreased expression of RETN mRNA CTD PMID:25345581 NCBI chr 8:3,655,770...3,659,818
Ensembl chr 8:3,655,770...3,660,110
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO hesperetin binds to SHBG protein CTD PMID:25349334 NCBI chr11:69,610,282...69,618,026
Ensembl chr11:69,614,804...69,617,905
JBrowse link
G Sirt6 sirtuin 6 increases expression
multiple interactions
ISO hesperetin results in increased expression of SIRT6 protein
[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein
CTD PMID:31153982 NCBI chr10:81,621,787...81,627,792
Ensembl chr10:81,621,785...81,627,797
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] CTD PMID:33522063 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression EXP hesperetin results in increased expression of SOD1 protein CTD PMID:19023542 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression EXP hesperetin results in increased expression of SOD2 protein CTD PMID:19023542 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sox18 SRY (sex determining region Y)-box 18 multiple interactions EXP hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]] CTD PMID:32762101 NCBI chr 2:181,669,837...181,671,640
Ensembl chr 2:181,669,836...181,671,640
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein] CTD PMID:28428136 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:33522063 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression
EXP
ISO
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
hesperetin affects the expression of TNF protein
hesperetin results in decreased expression of TNF mRNA
CTD PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 PMID:28428136 PMID:32762101 PMID:33522063 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] CTD PMID:15795422 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Utrn utrophin increases expression ISO hesperetin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr10:12,382,187...12,869,888
Ensembl chr10:12,382,188...12,869,365
JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO [2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Afp alpha fetoprotein multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein] CTD PMID:30779474 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alb albumin multiple interactions
increases expression
EXP [Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein
CTD PMID:29481770 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]
Hesperidin results in increased expression of BAX mRNA
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]
CTD PMID:24954035 PMID:29481770 PMID:32050098 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]
CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein
CTD PMID:22093918 PMID:29481770 PMID:30623541 PMID:30779474 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
increases activity
ISO
EXP
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]
Hesperidin results in increased activity of CAT protein
CTD PMID:22093918 PMID:29481770 PMID:30098279 PMID:30623541 PMID:30779474 PMID:31095933 PMID:32050098 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein] CTD PMID:17400256 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Fabp9 fatty acid binding protein 9, testis multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 3:10,193,623...10,197,283
Ensembl chr 3:10,193,621...10,197,283
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases activity
multiple interactions
ISO
EXP
Hesperidin results in decreased activity of G6PD protein
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]
CTD PMID:16427799 PMID:25130191 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gck glucokinase multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr11:5,900,816...5,950,081
Ensembl chr11:5,900,820...5,950,081
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble decreases activity
multiple interactions
EXP
ISO
Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein
CTD PMID:29481770 PMID:30779474 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gsr glutathione reductase multiple interactions ISO Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein] CTD PMID:28935427 PMID:32050098 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:17400256 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]
CTD PMID:17400256 PMID:21820093 PMID:30623541 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lep leptin decreases expression
multiple interactions
ISO Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein
CTD PMID:21820093 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mir126b microRNA 126b multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] CTD PMID:32050098 NCBI chr 2:26,591,363...26,591,420
Ensembl chr 2:26,591,363...26,591,420
JBrowse link
G Mir181a-2 microRNA 181a-2 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 2:38,852,735...38,852,810
Ensembl chr 2:38,852,735...38,852,810
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases secretion
ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein
CTD PMID:19110045 PMID:20138977 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions
ISO Hesperidin results in decreased activity of MPO protein
Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
CTD PMID:31095933 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein] CTD PMID:28935427 PMID:32050098 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA] CTD PMID:22093918 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]
CTD PMID:12512693 PMID:22093918 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]
CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]
CTD PMID:16101151 PMID:19110045 PMID:30098279 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 1:78,309,549...78,420,289
Ensembl chr 1:78,310,345...78,420,289
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 3:28,697,903...28,728,361
Ensembl chr 3:28,697,903...28,731,359
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr11:116,530,836...116,536,675
Ensembl chr11:116,530,925...116,536,674
Ensembl chr11:116,530,925...116,536,674
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr17:47,737,037...47,792,416
Ensembl chr17:47,737,030...47,792,419
JBrowse link
G Tnc tenascin C multiple interactions ISO Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 4:63,959,785...64,047,015
Ensembl chr 4:63,959,785...64,047,015
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:17400256 PMID:28935427 PMID:30623541 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 increases expression ISO Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 4:152,115,528...152,120,119
Ensembl chr 4:152,115,934...152,120,119
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr 8:105,258,575...105,264,594
Ensembl chr 8:105,258,286...105,264,609
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1
CTD PMID:17400256 PMID:30991044 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Ghrl ghrelin multiple interactions ISO [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
homoeriodictyol results in increased expression of NQO1 mRNA
CTD PMID:29902531 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
EXP
ISO
kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP
kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO
EXP
kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO
EXP
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21763
    chemical entity 21761
      atom 21749
        nonmetal atom 21645
          oxygen atom 20810
            oxygen molecular entity 20810
              organooxygen compound 20302
                ether 17576
                  aromatic ether 16465
                    methoxyflavanone 119
                      monomethoxyflavanone 119
                        (+)-tephrorin A 0
                        (2R,3R)-3-hydroxy-5-methoxy-6,7- methylenedioxyflavanone 0
                        (2S)-(-)-kurarinone + 0
                        (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                        (2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone 0
                        (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                        (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                        (2S)-6-(gamma,gamma-dimethylallyl)-5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                        (2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                        (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                        (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                        (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                        (2S)-poncirin 0
                        (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                        4'-methoxy-5,7-dihydroxyflavanone + 0
                        5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                        6-methoxyaromadendrin 3-O-acetate 0
                        6-methoxytaxifolin 0
                        dihydrooroxylin A 0
                        erylatissin C 0
                        exiguaflavanone B 0
                        hesperetin + 111
                        hesperetin 7-O-beta-D-glucoside 0
                        hesperidin + 58
                        homoeriodictyol + 21
                        kurarinol 5
                        leachianone A 0
                        maackiaflavanone A 0
                        matteucinol + 0
                        myrciacitrin II 0
                        neohesperidin 0
                        pinostrobin 0
                        sakuranetin + 0
                        sakuranin 0
                        tephrocandidin A 0
                        tephrocandidin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21763
    subatomic particle 21749
      composite particle 21749
        hadron 21749
          baryon 21749
            nucleon 21749
              atomic nucleus 21749
                atom 21749
                  main group element atom 21666
                    p-block element atom 21666
                      carbon group element atom 21478
                        carbon atom 21379
                          organic molecular entity 21379
                            organic molecule 21279
                              organic cyclic compound 20884
                                organic heterocyclic compound 19924
                                  oxacycle 18264
                                    benzopyran 10581
                                      1-benzopyran 10309
                                        flavonoid 6638
                                          flavans 3076
                                            flavanones 326
                                              methoxyflavanone 119
                                                monomethoxyflavanone 119
                                                  (+)-tephrorin A 0
                                                  (2R,3R)-3-hydroxy-5-methoxy-6,7- methylenedioxyflavanone 0
                                                  (2S)-(-)-kurarinone + 0
                                                  (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone 0
                                                  (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                                                  (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-6-(gamma,gamma-dimethylallyl)-5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                                                  (2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone 0
                                                  (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                                                  (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                                                  (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                                                  (2S)-poncirin 0
                                                  (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                                                  4'-methoxy-5,7-dihydroxyflavanone + 0
                                                  5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  6-methoxyaromadendrin 3-O-acetate 0
                                                  6-methoxytaxifolin 0
                                                  dihydrooroxylin A 0
                                                  erylatissin C 0
                                                  exiguaflavanone B 0
                                                  hesperetin + 111
                                                  hesperetin 7-O-beta-D-glucoside 0
                                                  hesperidin + 58
                                                  homoeriodictyol + 21
                                                  kurarinol 5
                                                  leachianone A 0
                                                  maackiaflavanone A 0
                                                  matteucinol + 0
                                                  myrciacitrin II 0
                                                  neohesperidin 0
                                                  pinostrobin 0
                                                  sakuranetin + 0
                                                  sakuranin 0
                                                  tephrocandidin A 0
                                                  tephrocandidin B 0
paths to the root