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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omethoate
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Accession:CHEBI:38730 term browser browse the term
Definition:An organothiophosphate insecticide that has formula C5H12NO4PS.
Synonyms:exact_synonym: O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] phosphorothioate
 related_synonym: 2-Dimethoxyphosphinoylthio-N-methylacetamide;   Dimethoxon;   Formula=C5H12NO4PS;   InChI=1S/C5H12NO4PS/c1-6-5(7)4-12-11(8,9-2)10-3/h4H2,1-3H3,(H,6,7);   InChIKey=PZXOQEXFMJCDPG-UHFFFAOYSA-N;   O,O-Dimethyl S-((methylcarbamoyl)methyl)phosphorothioate;   O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorothiolate;   O,O-Dimethyl S-(N-methylcarbamoylmethyl) thiophosphate;   O,O-Dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate;   O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] thiophosphate;   Phosphorothioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester;   SMILES=CNC(=O)CSP(=O)(OC)OC
 xref: Beilstein:1785256;   CAS:1113-02-6;   KEGG:C18662
 xref_mesh: MESH:C002302
 xref: PPDB:492



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omethoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
asoxime chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]
dimethoxon metabolite results in decreased activity of ACHE protein; dimethoxon results in decreased activity of ACHE protein
CTD PMID:8783813 PMID:11985885 PMID:15793557 PMID:18070496 PMID:30625376 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO dimethoxon binds to and results in decreased activity of BCHE protein CTD PMID:20229498 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Becn1 beclin 1 decreases expression ISO dimethoxon results in decreased expression of BECN1 mRNA CTD PMID:26688254 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp8 caspase 8 decreases expression ISO dimethoxon results in decreased expression of CASP8 mRNA CTD PMID:26688254 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO dimethoxon results in increased expression of CCND1 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased expression of CCND1 protein]
CTD PMID:31574243 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
affects response to substance
ISO dimethoxon results in decreased expression of CDKN1A mRNA
CDKN1A gene SNP affects the susceptibility to dimethoxon
CTD PMID:28718371 PMID:31405322 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased phosphorylation of GSK3B protein] CTD PMID:31574243 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Mir145 microRNA 145 affects response to substance ISO MIR145 gene SNP affects the susceptibility to dimethoxon CTD PMID:30684755 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO dimethoxon results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Tnks tankyrase increases response to substance ISO TNKS 3' UTR SNP results in increased susceptibility to dimethoxon CTD PMID:31551201 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO dimethoxon results in decreased expression of TP53 mRNA CTD PMID:28718371 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19800
    role 19751
      application 19498
        agrochemical 15187
          omethoate 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                acetamides 12410
                                                  acetamide 5470
                                                    N-methyl-2-sulfanylacetamide 52
                                                      omethoate 11
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