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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omethoate
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Accession:CHEBI:38730 term browser browse the term
Definition:An organothiophosphate insecticide that has formula C5H12NO4PS.
Synonyms:exact_synonym: O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] phosphorothioate
 related_synonym: 2-Dimethoxyphosphinoylthio-N-methylacetamide;   Dimethoxon;   Formula=C5H12NO4PS;   InChI=1S/C5H12NO4PS/c1-6-5(7)4-12-11(8,9-2)10-3/h4H2,1-3H3,(H,6,7);   InChIKey=PZXOQEXFMJCDPG-UHFFFAOYSA-N;   O,O-Dimethyl S-((methylcarbamoyl)methyl)phosphorothioate;   O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorothiolate;   O,O-Dimethyl S-(N-methylcarbamoylmethyl) thiophosphate;   O,O-Dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate;   O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] thiophosphate;   Phosphorothioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester;   SMILES=CNC(=O)CSP(=O)(OC)OC
 xref: Beilstein:1785256;   CAS:1113-02-6;   KEGG:C18662
 xref_mesh: MESH:C002302
 xref: PPDB:492


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omethoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
asoxime chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]
dimethoxon metabolite results in decreased activity of ACHE protein; dimethoxon results in decreased activity of ACHE protein
CTD PMID:8783813, PMID:11985885, PMID:15793557, PMID:18070496, PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO dimethoxon binds to and results in decreased activity of BCHE protein CTD PMID:20229498 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Becn1 beclin 1 decreases expression ISO dimethoxon results in decreased expression of BECN1 mRNA CTD PMID:26688254 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp8 caspase 8 decreases expression ISO dimethoxon results in decreased expression of CASP8 mRNA CTD PMID:26688254 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO dimethoxon results in increased expression of CCND1 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased expression of CCND1 protein]
CTD PMID:31574243 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO dimethoxon results in decreased expression of CDKN1A mRNA CTD PMID:28718371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased phosphorylation of GSK3B protein] CTD PMID:31574243 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO dimethoxon results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO dimethoxon results in decreased expression of TP53 mRNA CTD PMID:28718371 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        agrochemical 14436
          omethoate 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                acetamides 12382
                                                  acetamide 5454
                                                    N-methyl-2-sulfanylacetamide 49
                                                      omethoate 9
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