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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl 3-hydroxybut-2-enoate
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Accession:CHEBI:38726 term browser browse the term
Definition:A fatty acid methyl ester that has formula C5H8O3.
Synonyms:related_synonym: Formula=C5H8O3;   InChI=1S/C5H8O3/c1-4(6)3-5(7)8-2/h3,6H,1-2H3;   InChIKey=DHVOJYDALVUWPZ-UHFFFAOYSA-N;   SMILES=COC(=O)C=C(C)O
 xref: Beilstein:1922453


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mevinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO [Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] CTD PMID:4859365 PMID:8783813 PMID:21251949 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions		 ISO Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]		 CTD PMID:23824088 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression		 ISO [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein		 CTD PMID:23824088 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions		 ISO Mevinphos results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]		 CTD PMID:24462917 PMID:25449601 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] CTD PMID:21390240 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO Mevinphos results in increased phosphorylation of ATF2 protein CTD PMID:23157661 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Bax BCL2-associated X protein affects expression
multiple interactions		 ISO Mevinphos affects the expression of BAX protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]		 CTD PMID:17150954 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
affects expression		 ISO HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein] CTD PMID:17150954 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein] CTD PMID:17150954 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cep55 centrosomal protein 55 increases expression ISO Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein CTD PMID:25449601 NCBI chr19:38,043,423...38,062,873
Ensembl chr19:38,043,459...38,062,871 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac increases activity ISO Mevinphos results in increased activity of CHRM2 protein CTD PMID:17395621 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases activity ISO Mevinphos results in increased activity of CHRM4 protein CTD PMID:17395621 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:19333137 PMID:21390240 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Mevinphos results in increased expression of HMOX1 protein
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]		 CTD PMID:19333137 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa9 heat shock protein 9 increases expression ISO Mevinphos results in increased expression of HSPA9 protein CTD PMID:17150954 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression
multiple interactions		 ISO Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]		 CTD PMID:17150954 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Il2 interleukin 2 decreases response to substance EXP Mevinphos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Jun jun proto-oncogene increases phosphorylation ISO Mevinphos results in increased phosphorylation of JUN protein CTD PMID:23157661 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K6 protein CTD PMID:23157661 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
increases expression
increases activity		 ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]
Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein
Mevinphos results in increased activity of NOS1 protein		 CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 More... NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
increases activity		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein
Mevinphos results in increased activity of NOS2 protein		 CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
increases phosphorylation		 ISO PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]
Mevinphos results in increased phosphorylation of PIK3R1 protein		 CTD PMID:24462917 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions
increases expression		 ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]
Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein		 CTD PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:28601397 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity		 ISO AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:17395621 PMID:24462917 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Mevinphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions ISO Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr17:25,479,484...25,494,965
Ensembl chr17:25,479,482...25,493,856 		JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 increases expression
multiple interactions		 ISO Mevinphos results in increased expression of UCHL1 protein
Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]		 CTD PMID:15545831 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        fuel 11462
          methanol 3985
            methyl ester 3920
              fatty acid methyl ester 46
                methyl 3-hydroxybut-2-enoate 32
                  mevinphos 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      monocarboxylic acid 18952
                                        fatty acid 17131
                                          unsaturated fatty acid 1091
                                            monounsaturated fatty acid 598
                                              butenoic acid 32
                                                2-butenoic acid 32
                                                  methyl 3-hydroxybut-2-enoate 32
                                                    mevinphos 32
paths to the root