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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methamidophos
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Accession:CHEBI:38721 term browser browse the term
Definition:An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.
Synonyms:exact_synonym: O,S-dimethyl phosphoroamidothioate
 related_synonym: Formula=C2H8NO2PS;   InChI=1S/C2H8NO2PS/c1-5-6(3,4)7-2/h1-2H3,(H2,3,4);   InChIKey=NNKVPIKMPCQWCG-UHFFFAOYSA-N;   Metamidophos;   Methyl phosphoramidothioate;   O,S-Dimethyl phosphoramidothiolate;   O,S-dimethyl amidothiophosphate;   Phosphoramidothioic acid, o,s-dimethyl ester;   SMILES=COP(N)(=O)SC;   thiophosphoramidic acid O,S-dimethyl ester
 xref: Beilstein:1098870;   CAS:10265-92-6;   KEGG:C18667
 xref_mesh: MESH:C014655
 xref: PMID:27990599;   PMID:28036051;   PMID:28540662;   PPDB:453;   Reaxys:8137714


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methamidophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[methamidophos co-treated with decamethrin] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; methamidophos binds to and results in increased phosphorylation of ACHE protein; methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; methamidophos promotes the reaction [Paraoxon results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Paraoxon promotes the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]
methamidophos metabolite results in decreased activity of ACHE protein; methamidophos results in decreased activity of ACHE protein
methamidophos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein; methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein]
CTD PMID:1781739 PMID:2097819 PMID:8783813 PMID:9074804 PMID:11048668 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO methamidophos results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO methamidophos results in decreased activity of BCHE protein
methamidophos binds to and results in decreased activity of BCHE protein; Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of BCHE protein]
CTD PMID:9890196 PMID:20229498 PMID:21673941 PMID:22542756 PMID:26200596 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Becn1 beclin 1 increases expression ISO methamidophos results in increased expression of BECN1 mRNA CTD PMID:26688254 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Cat catalase multiple interactions EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein CTD PMID:10874619 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
increases secretion
EXP Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]; methamidophos promotes the reaction [FOS protein binds to CRH promoter]; Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein] CTD PMID:12039681 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO methamidophos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO methamidophos results in decreased activity of FAAH protein CTD PMID:11350214
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP methamidophos promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects activity
ISO methamidophos inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]
methamidophos affects the activity of HTR1A protein
CTD PMID:21871486 PMID:23596261 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects activity ISO methamidophos affects the activity of HTR2A protein CTD PMID:23596261 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Mir122 microRNA 122 decreases expression ISO methamidophos results in decreased expression of MIR122 mRNA CTD PMID:30602960 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir126b microRNA 126b increases expression ISO methamidophos results in increased expression of MIR126 mRNA CTD PMID:30602960 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir141 microRNA 141 decreases expression ISO methamidophos results in decreased expression of MIR141 mRNA CTD PMID:30602960 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir142 microRNA 142 increases expression ISO methamidophos results in increased expression of MIR142 mRNA CTD PMID:30602960 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
JBrowse link
G Mir150 microRNA 150 decreases expression ISO methamidophos results in decreased expression of MIR150 mRNA CTD PMID:30602960 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
JBrowse link
G Mir155 microRNA 155 decreases expression ISO methamidophos results in decreased expression of MIR155 mRNA CTD PMID:30602960 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir192 microRNA 192 increases expression ISO methamidophos results in increased expression of MIR192 mRNA CTD PMID:30602960 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mir193b microRNA 193b decreases expression ISO methamidophos results in decreased expression of MIR193B mRNA CTD PMID:30602960 NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
JBrowse link
G Mir223 microRNA 223 increases expression ISO methamidophos results in increased expression of MIR223 mRNA CTD PMID:30602960 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir27a microRNA 27a increases expression ISO methamidophos results in increased expression of MIR27A mRNA CTD PMID:30602960 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir28 microRNA 28 increases expression ISO methamidophos results in increased expression of MIR28 mRNA CTD PMID:30602960 NCBI chr11:75,975,523...75,975,608
Ensembl chr11:75,975,523...75,975,608
JBrowse link
G Mir375 microRNA 375 increases expression ISO methamidophos results in increased expression of MIR375 mRNA CTD PMID:30602960 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mirlet7g microRNA let-7g increases expression ISO methamidophos results in increased expression of MIRLET7G mRNA CTD PMID:30602960 NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity
increases phosphorylation
EXP
ISO
methamidophos results in decreased activity of PNPLA6 protein
methamidophos results in increased phosphorylation of PNPLA6 protein
CTD PMID:1781739 PMID:2170085 PMID:2238440 PMID:10447555 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Pomc proopiomelanocortin increases expression EXP methamidophos results in increased expression of POMC protein alternative form CTD PMID:11048668 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO methamidophos results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO methamidophos inhibits the reaction [Ketanserin binds to SLC6A4 protein] CTD PMID:21871486 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression
multiple interactions
EXP methamidophos results in decreased expression of TSHB protein
[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]
CTD PMID:15891268 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
acephate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein] CTD PMID:9074804 PMID:11048668 PMID:12039681 PMID:22778074 PMID:23000449 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO acephate results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP acephate results in decreased expression of BCHE protein CTD PMID:31326399 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
acephate results in decreased activity of CAT protein
CTD PMID:10874619 PMID:22034174 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Crh corticotropin releasing hormone increases expression
multiple interactions
increases secretion
EXP acephate results in increased expression of CRH mRNA
acephate promotes the reaction [FOS protein binds to CRH promoter]; Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]
CTD PMID:12039681 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP1A1 protein; [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B2 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP acephate promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC1 protein] CTD PMID:22778074 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gpt glutamic--pyruvic transaminase decreases expression EXP acephate results in decreased expression of GPT protein CTD PMID:33217513 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein] CTD PMID:19118596 PMID:22778074 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        agrochemical 15039
          methamidophos 39
            acephate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                pnictogen oxoacid 10688
                                  phosphorus oxoacid 9669
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8171
                                          phosphate 8170
                                            organic phosphate 8169
                                              organic thiophosphate 3715
                                                methamidophos 39
                                                  acephate 16
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