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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methamidophos
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Accession:CHEBI:38721 term browser browse the term
Definition:An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.
Synonyms:exact_synonym: O,S-dimethyl phosphoroamidothioate
 related_synonym: Formula=C2H8NO2PS;   InChI=1S/C2H8NO2PS/c1-5-6(3,4)7-2/h1-2H3,(H2,3,4);   InChIKey=NNKVPIKMPCQWCG-UHFFFAOYSA-N;   Metamidophos;   Methyl phosphoramidothioate;   O,S-Dimethyl phosphoramidothiolate;   O,S-dimethyl amidothiophosphate;   Phosphoramidothioic acid, o,s-dimethyl ester;   SMILES=COP(N)(=O)SC;   thiophosphoramidic acid O,S-dimethyl ester
 xref: Beilstein:1098870;   CAS:10265-92-6;   KEGG:C18667
 xref_mesh: MESH:C014655
 xref: PMID:27990599;   PMID:28036051;   PMID:28540662;   PPDB:453;   Reaxys:8137714


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methamidophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[methamidophos co-treated with decamethrin] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; methamidophos binds to and results in increased phosphorylation of ACHE protein; methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; methamidophos promotes the reaction [Paraoxon results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Paraoxon promotes the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]
methamidophos metabolite results in decreased activity of ACHE protein; methamidophos results in decreased activity of ACHE protein
methamidophos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein; methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein]
CTD PMID:1781739, PMID:2097819, PMID:8783813, PMID:9074804, PMID:11048668, PMID:11453739, PMID:12039681, PMID:12191869, PMID:15522598, PMID:16119251, PMID:17382909, PMID:17402711, PMID:18070496, PMID:18804659, PMID:19371630, PMID:19371631, PMID:19442833, PMID:21673941, PMID:22198100, PMID:22542756, PMID:22982773, PMID:23125138, PMID:23596261, PMID:26200596, PMID:27132127, PMID:30602960, PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO methamidophos results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO methamidophos results in decreased activity of BCHE protein
methamidophos binds to and results in decreased activity of BCHE protein; Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of BCHE protein]
CTD PMID:9890196, PMID:20229498, PMID:21673941, PMID:22542756, PMID:26200596 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Becn1 beclin 1 increases expression ISO methamidophos results in increased expression of BECN1 mRNA CTD PMID:26688254 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Cat catalase multiple interactions EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein CTD PMID:10874619 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
increases secretion
EXP Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]; methamidophos promotes the reaction [FOS protein binds to CRH promoter]; Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein] CTD PMID:12039681 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO methamidophos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO methamidophos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP methamidophos promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects activity
ISO methamidophos inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]
methamidophos affects the activity of HTR1A protein
CTD PMID:21871486, PMID:23596261 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects activity ISO methamidophos affects the activity of HTR2A protein CTD PMID:23596261 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Mir122 microRNA 122 decreases expression ISO methamidophos results in decreased expression of MIR122 mRNA CTD PMID:30602960 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir126b microRNA 126b increases expression ISO methamidophos results in increased expression of MIR126 mRNA CTD PMID:30602960 NCBI chr 3:4,042,488...4,042,560 JBrowse link
G Mir141 microRNA 141 decreases expression ISO methamidophos results in decreased expression of MIR141 mRNA CTD PMID:30602960 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mir142 microRNA 142 increases expression ISO methamidophos results in increased expression of MIR142 mRNA CTD PMID:30602960 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942
JBrowse link
G Mir150 microRNA 150 decreases expression ISO methamidophos results in decreased expression of MIR150 mRNA CTD PMID:30602960 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir155 microRNA 155 decreases expression ISO methamidophos results in decreased expression of MIR155 mRNA CTD PMID:30602960 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir192 microRNA 192 increases expression ISO methamidophos results in increased expression of MIR192 mRNA CTD PMID:30602960 NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
JBrowse link
G Mir193b microRNA 193b decreases expression ISO methamidophos results in decreased expression of MIR193B mRNA CTD PMID:30602960 NCBI chr14:30,331,049...30,331,131
Ensembl chr14:30,331,049...30,331,131
JBrowse link
G Mir223 microRNA 223 increases expression ISO methamidophos results in increased expression of MIR223 mRNA CTD PMID:30602960 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir27a microRNA 27a increases expression ISO methamidophos results in increased expression of MIR27A mRNA CTD PMID:30602960 NCBI chr19:25,318,736...25,318,822
Ensembl chr19:25,318,736...25,318,822
JBrowse link
G Mir28 microRNA 28 increases expression ISO methamidophos results in increased expression of MIR28 mRNA CTD PMID:30602960 NCBI chr11:79,380,523...79,380,608
Ensembl chr11:79,380,523...79,380,608
JBrowse link
G Mir375 microRNA 375 increases expression ISO methamidophos results in increased expression of MIR375 mRNA CTD PMID:30602960 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Mirlet7g microRNA let-7g increases expression ISO methamidophos results in increased expression of MIRLET7G mRNA CTD PMID:30602960 NCBI chr 8:114,874,457...114,874,544
Ensembl chr 8:114,874,454...114,874,550
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity
increases phosphorylation
EXP
ISO
methamidophos results in decreased activity of PNPLA6 protein
methamidophos results in increased phosphorylation of PNPLA6 protein
CTD PMID:1781739, PMID:2170085, PMID:2238440, PMID:10447555 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Pomc proopiomelanocortin increases expression EXP methamidophos results in increased expression of POMC protein alternative form CTD PMID:11048668 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO methamidophos results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO methamidophos inhibits the reaction [Ketanserin binds to SLC6A4 protein] CTD PMID:21871486 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression
multiple interactions
EXP methamidophos results in decreased expression of TSHB protein
[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]
CTD PMID:15891268 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
acephate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein] CTD PMID:9074804, PMID:11048668, PMID:12039681, PMID:22778074, PMID:23000449 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO acephate results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP acephate results in decreased expression of BCHE protein CTD PMID:31326399 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
acephate results in decreased activity of CAT protein
CTD PMID:10874619, PMID:22034174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Crh corticotropin releasing hormone increases expression
multiple interactions
increases secretion
EXP acephate results in increased expression of CRH mRNA
acephate promotes the reaction [FOS protein binds to CRH promoter]; Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]
CTD PMID:12039681 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP1A1 protein; [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B2 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP acephate promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC protein] CTD PMID:22778074 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein] CTD PMID:19118596, PMID:22778074 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        agrochemical 14435
          methamidophos 38
            acephate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              organic thiophosphate 2814
                                                methamidophos 38
                                                  acephate 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.