carboxylic acid dianion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	carboxylic acid dianion	go back to main search page
Accession:	CHEBI:38716	browse the term
Definition:	Any dianion containing at least one carboxy group.
Synonyms:	related_synonym:	carboxylic acid dianions

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Rat (255 ) Mouse (255 ) Human (262 ) Chinchilla (0 ) Bonobo (0 ) Dog (3 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (255)

calcium oxalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases cleavage

ISO

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions
decreases expression

EXP

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

EXP

Calcium Oxalate results in decreased expression of CCL2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CCL2 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]

PMID:37414240 PMID:37454925

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

CD44 molecule

multiple interactions
decreases expression

EXP

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CD44 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]

PMID:37414240 PMID:37454925

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

cytochrome b-245 beta chain

multiple interactions
increases expression

EXP

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of CYBB protein]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

EXP

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA]

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:247,966,346...248,022,388

G

histone deacetylase 1

multiple interactions

EXP

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA]

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 2

multiple interactions

EXP

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA]

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

histone deacetylase 3

multiple interactions

EXP

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA]

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025

G

histone deacetylase 8

multiple interactions

EXP

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA]

NCBI chr X:71,425,240...71,632,865
Ensembl chr X:71,394,928...71,632,865

G

heme oxygenase 1

multiple interactions
increases expression

ISO

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression
multiple interactions

EXP

Calcium Oxalate results in increased expression of ITPR1 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein]

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

inositol 1,4,5-trisphosphate receptor, type 2

multiple interactions
increases expression

EXP

Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein]

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:180,760,442...181,164,763

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

EXP

Calcium Oxalate results in increased expression of ITPR3 protein

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,118,834...5,204,184

G

NADPH oxidase 4

increases expression
multiple interactions

EXP

Calcium Oxalate results in increased expression of NOX4 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX4 protein]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

sirtuin 1

multiple interactions
decreases expression

ISO

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

superoxide dismutase 1

multiple interactions
decreases expression

EXP

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

secreted phosphoprotein 1

multiple interactions
decreases expression

EXP

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]

PMID:37414240 PMID:37454925

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO

Carboplatin results in decreased expression of ABCB1 mRNA; Carboplatin results in decreased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

decreases expression

EXP

Carboplatin results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 1

decreases expression

ISO

Carboplatin results in decreased expression of ABCC1 mRNA; Carboplatin results in decreased expression of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

decreases expression

ISO

Carboplatin results in decreased expression of ABCC2 mRNA; Carboplatin results in decreased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

decreases expression

ISO

Carboplatin results in decreased expression of ABCG2 mRNA; Carboplatin results in decreased expression of ABCG2 protein

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

activin A receptor type 1C

increases response to substance

ISO

ACVR1C results in increased susceptibility to Carboplatin

NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:63,227,559...63,301,205

G

aryl hydrocarbon receptor

decreases expression

ISO

Carboplatin results in decreased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member B1

increases expression

EXP

Carboplatin results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:63,899,222...63,913,315

G

AKT serine/threonine kinase 1

multiple interactions

ISO

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]; Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]

PMID:18483861 PMID:33190582

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

5'-aminolevulinate synthase 2

decreases expression

EXP

Carboplatin results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:22,890,689...22,914,043

G

aldehyde dehydrogenase 1 family, member A1

affects response to substance

ISO

ALDH1A1 protein affects the susceptibility to Carboplatin

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 3 family, member A1

affects response to substance

ISO

ALDH3A1 protein affects the susceptibility to Carboplatin

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

annexin A4

decreases response to substance
affects localization
multiple interactions

ISO

ANXA4 protein results in decreased susceptibility to Carboplatin
Carboplatin affects the localization of ANXA4 protein
ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:120,741,750...120,798,513

G

ARF guanine nucleotide exchange factor 1

increases response to substance

ISO

ARFGEF1 results in increased susceptibility to Carboplatin

NCBI chr 5:13,764,507...13,859,237
Ensembl chr 5:13,764,975...13,859,237

G

ARF like GTPase 4C

affects response to substance

ISO

ARL4C protein affects the susceptibility to Carboplatin

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:96,745,069...96,752,772

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression

EXP

Carboplatin results in decreased expression of ATP1A1 mRNA

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase copper transporting alpha

affects localization
multiple interactions

ISO

Carboplatin affects the localization of ATP7A protein
[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]

PMID:24038379 PMID:24150977

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

ATPase copper transporting beta

multiple interactions

ISO

ATP7B protein binds to and results in increased metabolism of Carboplatin

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression
multiple interactions

ISO

Carboplatin results in decreased expression of BAX mRNA
Carboplatin results in increased expression of BAX mRNA; Carboplatin results in increased expression of BAX protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; Carboplatin results in increased cleavage of and results in increased expression of BAX protein

PMID:15131059 PMID:15576332 PMID:33002289

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Carboplatin results in decreased expression of BCL2 mRNA; Carboplatin results in decreased expression of BCL2 protein

PMID:9664115 PMID:15576332 PMID:15996812 PMID:17404015

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression
multiple interactions

ISO
EXP

Carboplatin results in decreased expression of BCL2L1 protein
Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2 like 12

increases expression

ISO

Carboplatin results in increased expression of BCL2L12 mRNA

NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:104,608,753...104,617,472

G

beclin 1

decreases expression
multiple interactions

ISO

Carboplatin results in decreased expression of BECN1 protein
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

baculoviral IAP repeat-containing 2

decreases response to substance

ISO

BIRC2 protein results in decreased susceptibility to Carboplatin

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

bleomycin hydrolase

decreases expression

EXP

Carboplatin results in decreased expression of BLMH mRNA

NCBI chr10:61,772,112...61,815,212
Ensembl chr10:62,270,033...62,313,345

G

BRCA1, DNA repair associated

decreases activity

ISO

Carboplatin results in decreased activity of BRCA1 protein

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

calcium/calmodulin-dependent protein kinase kinase 2

affects response to substance

ISO

CAMKK2 protein affects the susceptibility to Carboplatin

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:39,451,834...39,514,964

G

calnexin

decreases expression

EXP

Carboplatin results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:35,124,941...35,157,857

G

caspase 2

decreases expression

EXP

Carboplatin results in decreased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
increases activity
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 protein; Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]
Carboplatin results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]
[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein; Carboplatin promotes the reaction [[Pulsatilla saponin A co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pulsatilla saponin A promotes the reaction [[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]
Carboplatin results in increased expression of CASP3 mRNA; Carboplatin results in increased expression of CASP3 protein

PMID:15576332 PMID:16275998 PMID:18483861 PMID:20368269 PMID:22302033 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity
multiple interactions

ISO

Carboplatin results in increased activity of CASP7 protein
palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases activity
decreases expression
multiple interactions
increases expression

ISO
EXP

Carboplatin results in increased activity of CASP9 protein
Carboplatin results in decreased expression of CASP9 mRNA
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]

PMID:15576332 PMID:15996812 PMID:17404015 PMID:18483861

Ensembl chr 5:159,391,188...159,409,648

G

catalase

decreases activity
decreases expression
multiple interactions

EXP

Carboplatin results in decreased activity of CAT protein
Carboplatin results in decreased expression of CAT protein
Carboplatin results in decreased expression of and results in decreased activity of CAT protein

PMID:11124453 PMID:15109710 PMID:15225673

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin D1

multiple interactions

ISO

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

CD274 molecule

decreases expression

ISO

Carboplatin results in decreased expression of CD274; Carboplatin results in decreased expression of CD274 protein

PMID:21765211 PMID:27692344

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:236,496,463...236,549,951

G

CD44 molecule

decreases expression

EXP

Carboplatin results in decreased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

cell division cycle 25B

decreases expression

EXP

Carboplatin results in decreased expression of CDC25B mRNA

NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492

G

cell division cycle 42

decreases expression

EXP

Carboplatin results in decreased expression of CDC42 mRNA

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO
EXP

Carboplatin results in increased expression of CDKN1A protein
Carboplatin results in increased expression of CDKN1A mRNA

PMID:9664115 PMID:18172885

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

EXP

Carboplatin results in increased expression of CITED2 mRNA

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

clusterin

decreases expression

EXP

Carboplatin results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

COP9 signalosome subunit 5

increases response to substance

ISO

COPS5 results in increased susceptibility to Carboplatin

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:13,975,052...13,993,387

G

cytochrome c, somatic

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

dopachrome tautomerase

decreases response to substance

ISO

DCT protein results in decreased susceptibility to Carboplatin

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029

G

DNA-damage inducible transcript 3

increases expression

EXP

Carboplatin results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dihydropyrimidine dehydrogenase

multiple interactions

ISO

PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

eukaryotic translation initiation factor 2 subunit alpha

affects phosphorylation

ISO

Carboplatin affects the phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:103,405,788...103,431,649

G

epithelial cell adhesion molecule

multiple interactions

ISO

[Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

erythropoietin

increases expression

EXP

Carboplatin results in increased expression of EPO protein

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

ISO

ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin]

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

Fas cell surface death receptor

increases expression

ISO

Carboplatin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

follicle stimulating hormone subunit beta

increases expression

EXP

Carboplatin results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:114,003,262...114,007,072

G

glutathione-disulfide reductase

decreases activity

EXP

Carboplatin results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase pi 1

affects response to substance

ISO

GSTP1 gene affects the susceptibility to Carboplatin

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

ISO

Carboplatin results in increased expression of H2AX protein
Carboplatin results in increased phosphorylation of H2AX protein
palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; phellopterin promotes the reaction [[Carboplatin results in increased phosphorylation of H2AX protein] which results in increased susceptibility to Carboplatin]; phellopterin promotes the reaction [Carboplatin results in increased phosphorylation of H2AX protein]

PMID:22302033 PMID:37708916

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

HCLS1 associated protein X-1

multiple interactions

EXP

Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein]

NCBI chr 2:177,731,918...177,735,670
Ensembl chr 2:177,731,921...177,735,390

G

hemoglobin subunit beta

decreases expression

EXP

Carboplatin results in decreased expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

heme oxygenase 1

multiple interactions
increases expression
decreases response to substance
decreases expression

ISO
EXP

HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]
Carboplatin results in increased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Carboplatin
Carboplatin results in decreased expression of HMOX1 mRNA

PMID:18172885 PMID:20368269 PMID:21198546 PMID:26260164

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

EXP

Carboplatin results in decreased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:45,515,373...45,604,467

G

heat shock protein family A (Hsp70) member 1A

increases expression

EXP

Carboplatin results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

increases expression

EXP

Carboplatin results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

decreases expression

EXP

Carboplatin results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

increases expression

EXP

Carboplatin results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

insulin-like growth factor 2 receptor

decreases expression

EXP

Carboplatin results in decreased expression of IGF2R mRNA

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265

G

interleukin 6

decreases response to substance

ISO

IL6 protein results in decreased susceptibility to Carboplatin

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

decreases response to substance

ISO

IL6R protein results in decreased susceptibility to Carboplatin

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Carboplatin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

kallikrein 1-related peptidase C10

multiple interactions

ISO

[Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:103,539,527...103,543,586

G

mitogen-activated protein kinase kinase kinase 1

decreases expression

EXP

Carboplatin results in decreased expression of MAP3K1 mRNA

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase kinase kinase 12

decreases expression

EXP

Carboplatin results in decreased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:135,508,790...135,515,137

G

mitogen activated protein kinase 14

decreases expression

EXP

Carboplatin results in decreased expression of MAPK14 mRNA

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen-activated protein kinase 6

decreases expression

EXP

Carboplatin results in decreased expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:85,027,144...85,050,236

G

O-6-methylguanine-DNA methyltransferase

decreases expression

EXP

Carboplatin results in decreased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microRNA 155

multiple interactions

ISO

[Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178

G

marker of proliferation Ki-67

multiple interactions

ISO

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

myeloperoxidase

multiple interactions

EXP

[Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mutS homolog 2

decreases expression

EXP

Carboplatin results in decreased expression of MSH2 mRNA

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

mutS homolog 6

affects response to substance

ISO

MSH6 protein affects the susceptibility to Carboplatin

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844

G

metallothionein 1A

decreases expression
increases expression

EXP
ISO

Carboplatin results in decreased expression of MT1A mRNA
Carboplatin results in increased expression of MT1A mRNA

PMID:18172885 PMID:35027733

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

MYC proto-oncogene, bHLH transcription factor

increases response to substance

ISO

MYC protein results in increased susceptibility to Carboplatin

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

Nanog homeobox

increases expression

ISO

Carboplatin results in increased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:157,615,687...157,623,061

G

NBAS subunit of NRZ tethering complex

affects response to substance

ISO

NBAS intron polymorphism affects the susceptibility to Carboplatin

NCBI chr 6:41,777,253...42,081,895
Ensembl chr 6:41,755,851...42,081,895

G

NCK-associated protein 1

decreases expression

EXP

Carboplatin results in decreased expression of NCKAP1 mRNA

NCBI chr 3:85,824,333...85,898,748
Ensembl chr 3:85,824,336...85,898,797

G

nuclear factor of activated T-cells 4

multiple interactions
increases activity

ISO
EXP

HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]

NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

ISO
EXP

Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]
Carboplatin results in decreased expression of NFKB1 mRNA

PMID:12675310 PMID:18172885

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

decreases phosphorylation
multiple interactions

ISO

Carboplatin results in decreased phosphorylation of NFKBIA protein
NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:12675310 PMID:15120608

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nodal growth differentiation factor

increases response to substance

ISO

NODAL results in increased susceptibility to Carboplatin

NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,911,258...29,919,659

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

Carboplatin results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

NRAS proto-oncogene, GTPase

decreases expression

EXP

Carboplatin results in decreased expression of NRAS mRNA

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543

G

olfactory receptor family 4 subfamily D member 6

affects response to substance

ISO

OR4D6 gene SNP affects the susceptibility to Carboplatin

NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:218,463,801...218,464,745

G

oncostatin M

increases expression

ISO

Carboplatin results in increased expression of OSM mRNA

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Carboplatin results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

poly (ADP-ribose) polymerase family, member 3

increases response to substance

ISO

PARP3 protein mutant form results in increased susceptibility to Carboplatin

NCBI chr 8:115,989,721...115,995,822
Ensembl chr 8:115,987,176...115,995,472

G

pro-apoptotic WT1 regulator

decreases expression

EXP

Carboplatin results in decreased expression of PAWR mRNA

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:45,531,637...45,611,492

G

proliferating cell nuclear antigen

multiple interactions
increases expression

ISO
EXP

PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]
Carboplatin results in increased expression of PCNA mRNA

PMID:16685392 PMID:18172885

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 1 ligand 2

decreases expression
multiple interactions

ISO

Carboplatin results in decreased expression of PDCD1LG2
STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]

NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:236,565,526...236,637,490

G

protein disulfide isomerase family A, member 4

decreases expression

EXP

Carboplatin results in decreased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:78,134,144...78,153,191

G

protein disulfide isomerase family A, member 6

decreases expression

EXP

Carboplatin results in decreased expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:45,791,678...45,810,091

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

Carboplatin results in increased expression of PMAIP1 protein

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

protein kinase D2

affects response to substance

ISO

PRKD2 protein affects the susceptibility to Carboplatin

NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675

G

proteasome 20S subunit beta 2

increases expression

EXP

Carboplatin results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:144,255,026...144,287,608

G

proteasome 20S subunit beta 4

decreases expression

EXP

Carboplatin results in decreased expression of PSMB4 mRNA

NCBI chr 2:185,131,787...185,134,561
Ensembl chr 2:185,131,786...185,135,287

G

prostaglandin-endoperoxide synthase 2

decreases response to substance
multiple interactions

ISO

PTGS2 protein results in decreased susceptibility to Carboplatin
wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAB10, member RAS oncogene family

decreases expression

EXP

Carboplatin results in decreased expression of RAB10 mRNA

NCBI chr 6:31,974,858...32,039,554
Ensembl chr 6:31,986,921...32,039,733

G

RNA binding motif protein 17

decreases response to substance

ISO

RBM17 protein results in decreased susceptibility to Carboplatin

NCBI chr17:66,937,140...66,954,034
Ensembl chr17:71,846,916...71,864,431

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Carboplatin results in decreased localization of and results in decreased activity of RELA protein; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:12675310 PMID:15120608

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

stearoyl-Coenzyme A desaturase 2

decreases expression

EXP

Carboplatin results in decreased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

salt-inducible kinase 1

increases response to substance

ISO

SIK1 results in increased susceptibility to Carboplatin

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

solute carrier family 31 member 1

decreases response to substance
multiple interactions
increases import
increases uptake
increases response to substance

ISO
EXP

SLC31A1 gene mutant form results in decreased susceptibility to Carboplatin
[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin
SLC31A1 protein results in increased import of Carboplatin
SLC31A1 protein results in increased uptake of Carboplatin
SLC31A1 protein results in increased susceptibility to Carboplatin

PMID:15634647 PMID:16847145 PMID:19509135 PMID:22914438 PMID:23123662

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 31 member 2

decreases uptake

ISO

SLC31A2 protein results in decreased uptake of Carboplatin

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:80,753,618...80,764,123

G

smoothened, frizzled class receptor

increases expression

ISO

Carboplatin results in increased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

superoxide dismutase 1

multiple interactions
decreases expression

EXP

Carboplatin results in decreased expression of and results in decreased activity of SOD1 protein
Carboplatin results in decreased expression of SOD1 protein

PMID:15109710 PMID:15225673

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP

Carboplatin results in increased expression of and results in increased activity of SOD2 protein
Carboplatin results in decreased expression of SOD2 protein

PMID:15109710 PMID:15225673

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 2

increases expression

ISO

Carboplatin results in increased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

signal transducer and activator of transcription 6

multiple interactions

ISO

STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795

G

serine threonine kinase 39

decreases expression

EXP

Carboplatin results in decreased expression of STK39 mRNA

NCBI chr 3:73,321,522...73,588,397
Ensembl chr 3:73,321,522...73,586,740

G

syntaxin 2

increases response to substance

ISO

STX2 protein results in increased susceptibility to Carboplatin

NCBI chr12:33,315,447...33,350,788
Ensembl chr12:33,315,750...33,350,788

G

transcription factor AP-2 alpha

increases response to substance

ISO

TFAP2A protein results in increased susceptibility to Carboplatin

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

tumor necrosis factor

multiple interactions

EXP

[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

DNA topoisomerase II alpha

multiple interactions

ISO

TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

tumor protein p53

increases expression
multiple interactions

ISO

Carboplatin results in increased expression of TP53 mRNA; Carboplatin results in increased expression of TP53 protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 protein

PMID:9664115 PMID:15131059 PMID:33002289

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thymidylate synthetase

multiple interactions

ISO

PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

UDP glucuronosyltransferase family 1 member A6

decreases expression

EXP

Carboplatin results in decreased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:96,144,786...96,256,264

G

vimentin

decreases expression

EXP

Carboplatin results in decreased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

xanthine dehydrogenase

affects activity

EXP

Carboplatin affects the activity of XDH protein

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

XPC complex subunit, DNA damage recognition and repair factor

decreases response to substance

ISO

XPC results in decreased susceptibility to Carboplatin

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:125,550,833...125,578,305

G

zinc finger protein 36, C3H type-like 1

decreases expression

EXP

Carboplatin results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:104,663,399...104,687,979

cromoglycate(2-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NME/NM23 nucleoside diphosphate kinase 2

affects binding

EXP

Chromoglycate binds to Nme2 protein

RGD

NCBI chr10:78,898,097...78,903,514
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

disodium cromoglycate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

EXP

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein]

PMID:35114312 PMID:36464070

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

ISO
EXP

Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

actin alpha 2, smooth muscle

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

increases expression

ISO

Cromolyn Sodium results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:91,226,180...91,240,169

G

adenosine A3 receptor

decreases activity

EXP

Cromolyn Sodium results in decreased activity of ADORA3 protein

NCBI chr 2:196,077,042...196,080,686
Ensembl chr 2:196,077,042...196,080,686

G

angiotensinogen

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein]

PMID:35114312 PMID:36464070

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

AKT serine/threonine kinase 1

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2, apoptosis regulator

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:178,312,638...178,317,529

G

cystatin C

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:156,790,079...156,793,937

G

catenin beta 1

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin D

multiple interactions

ISO

[pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

DNA methyltransferase 1

decreases expression

ISO

Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

G protein-coupled receptor 35

affects localization
multiple interactions

ISO
EXP

Cromolyn Sodium affects the localization of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]

PMID:20919992 PMID:22967846

NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:100,962,538...100,986,985

G

glutathione peroxidase 1

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

insulin 1

increases expression

ISO

Cromolyn Sodium results in increased expression of INS1 protein

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

mitogen activated protein kinase 1

decreases phosphorylation

ISO

Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

EXP
ISO

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein

PMID:28732690 PMID:35961540

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

ISO

Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein

NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487

G

matrix metallopeptidase 2

multiple interactions
increases expression

EXP

Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

proopiomelanocortin

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

renin

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein]

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

resistin

decreases expression

ISO

Cromolyn Sodium results in decreased expression of RETN protein

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:6,508,801...6,511,116

G

S100 calcium binding protein B

multiple interactions

EXP

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of S100P protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,348...12,381,081

G

solute carrier family 22 member 12

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein]

NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380

G

solute carrier family 22 member 6

multiple interactions

EXP

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein]

PMID:35114312 PMID:36464070

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

multiple interactions

EXP

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein]

PMID:35114312 PMID:36464070

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

superoxide dismutase 1

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

tachykinin, precursor 1

multiple interactions

EXP

Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein]

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

transforming growth factor, beta 1

multiple interactions
increases secretion

ISO
EXP

[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]
Cromolyn Sodium results in increased secretion of TGFB1 protein

PMID:35007524 PMID:35114312

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamate ionotropic receptor AMPA type subunit 1

increases localization

EXP

Glutamate increases localization of Gria1 protein within medium spiny neurons

RGD

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309

sodium aurothiomalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:98,246,605...98,260,214

G

adenosine A2a receptor

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,270...13,332,802

G

adhesion molecule with Ig like domain 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218

G

ANTXR cell adhesion molecule 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:121,148,103...121,336,892

G

aldehyde oxidase 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

BCL2-related protein A1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

bone marrow stromal cell antigen 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of BST2 mRNA

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967

G

C-C motif chemokine ligand 20

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

cellular communication network factor 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 5

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:172,910,681...172,922,062

G

Cd28 molecule

multiple interactions
affects response to substance

ISO

CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273

G

calmegin

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:41,601,568...41,633,325

G

collagen type I alpha 1 chain

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collectin sub-family member 12

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:1,005,741...1,195,297

G

C-X-C motif chemokine ligand 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 4

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

DEAD-box helicase 10

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of DDX10 mRNA

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:62,384,876...62,539,585

G

iodothyronine deiodinase 1

decreases activity

ISO

Gold Sodium Thiomalate results in decreased activity of DIO1 protein

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

EGF containing fibulin extracellular matrix protein 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:106,802,304...106,892,808

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleoside triphosphate diphosphohydrolase 3

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA

NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:129,124,709...129,156,252

G

fibrillarin

affects localization
decreases activity
multiple interactions

ISO

Gold Sodium Thiomalate affects the localization of FBL protein
Gold Sodium Thiomalate results in decreased activity of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:10942594 PMID:19077085

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:92,597,258...92,606,506

G

fibulin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA

NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965

G

fibroblast growth factor 7

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of FGF7 mRNA

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:133,734,673...133,786,328

G

guanylate binding protein 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

glycoprotein m6b

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of GPM6B mRNA

NCBI chr X:31,689,485...31,836,199
Ensembl chr X:31,690,359...31,733,272

G

gasdermin E

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:80,588,614...80,641,525

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:88,854,640...88,896,993

G

hypoxia inducible lipid droplet-associated

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:107,257,239...107,327,432

G

interferon, alpha-inducible protein 27

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:128,355,079...128,361,781

G

interferon-induced protein 35

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,887,122...86,889,750

G

interferon-induced protein 44

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:243,286,052...243,306,877

G

interferon-induced protein 44-like

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:243,328,723...243,366,404

G

interferon induced with helicase C domain 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:67,637,545...67,683,968

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:241,526,880...241,532,521

G

interferon gamma

multiple interactions
affects response to substance

ISO

IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

PMID:16393772 PMID:25314295

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor antagonist

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 23 subunit alpha

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IL23A mRNA

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 4

multiple interactions
affects response to substance

ISO

IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
decreases expression
affects response to substance

ISO

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:11824965 PMID:19077085 PMID:19192274

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interferon regulatory factor 7

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:205,796,959...205,800,023

G

ISG15 ubiquitin-like modifier

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:172,066,369...172,067,656

G

interferon stimulated exonuclease gene 20

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:142,236,137...142,246,401

G

laminin subunit beta 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:107,322,526...107,404,081

G

latexin

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:154,037,292...154,043,488

G

lymphocyte antigen 6 family member E

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:108,816,887...108,820,443

G

myristoylated alanine rich protein kinase C substrate

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA

NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

microRNA 99b

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased expression of MIR99B mRNA]

NCBI chr 1:67,350,064...67,350,133
Ensembl chr 1:67,350,060...67,350,139

G

matrix metallopeptidase 10

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:12,974,707...12,982,613

G

MX dynamin like GTPase 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:50,269,057...50,292,904

G

NDUFA4, mitochondrial complex associated like 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:65,242,135...65,244,277

G

neuromedin B

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NMB mRNA

NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:144,278,453...144,281,422

G

nitric oxide synthase 2

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

2'-5' oligoadenylate synthetase 1A

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA

NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128

G

2'-5'-oligoadenylate synthetase-like

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of OASL mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:47,343,551...47,356,483

G

olfactomedin-like 2B

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:85,402,169...85,439,342

G

phosphoglycerate dehydrogenase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:188,595,700...188,624,789

G

phospholipid phosphatase 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

protein phosphatase 4, regulatory subunit 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:135,010,919...135,051,844

G

prostaglandin E synthase

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

NCBI chr 3:14,177,892...14,189,236
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

retinoic acid receptor responder 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA

NCBI chr 2:154,059,761...154,094,021
Ensembl chr 2:154,059,761...154,094,024

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 4

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

RNA sensor RIG-1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:60,117,398...60,165,995

G

receptor-interacting serine-threonine kinase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:34,428,573...34,459,663

G

ring finger protein 19B

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA

NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394

G

radical S-adenosyl methionine domain containing 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:48,774,985...48,788,320

G

solute carrier family 7 member 11

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

spermine synthase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SMS mRNA

NCBI chr X:37,516,949...37,572,657
Ensembl chr X:41,331,799...41,387,712

G

superoxide dismutase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spondin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:177,363,197...177,662,676

G

signal transducer and activator of transcription 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

steroid sulfatase

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:46,102,548...46,111,104

G

thrombospondin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thrombospondin 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of THBS2 mRNA

NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:64,343,523...64,372,918

G

toll-like receptor 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

TNF alpha induced protein 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:136,298,082...136,311,106

G

thioredoxin interacting protein

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

multiple interactions
decreases activity

ISO
EXP

Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein

PMID:16510263 PMID:17229725

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

decreases activity

EXP

Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:96,024,324...96,072,475

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
molecular entity	20859
ion	17384
anion	16964
organic anion	6933
carboxylic acid anion	2620
carboxylic acid dianion	255
2-phospho-L-lactate	0
dicarboxylic acid dianion +	255
nedocromil(2-) +	0
nocamycin E(2-)	0
primary fluorescent chlorophyll catabolite(2-)	0
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
organic ion	11559
organic anion	6933
carboxylic acid anion	2620
carboxylic acid dianion	255
2-phospho-L-lactate	0
dicarboxylic acid dianion +	255
nedocromil(2-) +	0
nocamycin E(2-)	0
primary fluorescent chlorophyll catabolite(2-)	0

paths to the root