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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiomalic acid
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Accession:CHEBI:38705 term browser browse the term
Definition:A C4-dicarboxylic acid that has formula C4H6O4S.
Synonyms:exact_synonym: 2-sulfanylbutanedioic acid
 related_synonym: 2-mercaptosuccinic acid;   2-sulfanylsuccinic acid;   2-thiomalic acid;   Formula=C4H6O4S;   InChI=1S/C4H6O4S/c5-3(6)1-2(9)4(7)8/h2,9H,1H2,(H,5,6)(H,7,8);   InChIKey=NJRXVEJTAYWCQJ-UHFFFAOYSA-N;   SMILES=OC(=O)CC(S)C(O)=O;   alpha-mercaptosuccinic acid;   mercaptosuccinic acid;   monomercaptosuccinic acid
 xref: Beilstein:1099858;   CAS:70-49-5;   Gmelin:218084
 xref_mesh: MESH:C046062
 cyclic_relationship: is_conjugate_acid_of CHEBI:38708



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thiomalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G multiple interactions EXP [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein CTD PMID:16407272 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO 2-thiomalic acid results in decreased activity of GPX1 protein CTD PMID:21892612 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            anti-ulcer drug 791
              succinic acid 223
                thiomalic acid 3
                  (R)-thiomalic acid 0
                  (S)-thiomalic acid 0
                  aurothiomalic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      dicarboxylic acids and O-substituted derivatives 10368
                                        dicarboxylic acid 10361
                                          alpha,omega-dicarboxylic acid 2803
                                            succinic acid 223
                                              thiomalic acid 3
                                                (R)-thiomalic acid 0
                                                (S)-thiomalic acid 0
                                                aurothiomalic acid + 0
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