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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiomalic acid
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Accession:CHEBI:38705 term browser browse the term
Definition:A C4-dicarboxylic acid that has formula C4H6O4S.
Synonyms:exact_synonym: 2-sulfanylbutanedioic acid
 related_synonym: 2-mercaptosuccinic acid;   2-sulfanylsuccinic acid;   2-thiomalic acid;   Formula=C4H6O4S;   InChI=1S/C4H6O4S/c5-3(6)1-2(9)4(7)8/h2,9H,1H2,(H,5,6)(H,7,8);   InChIKey=NJRXVEJTAYWCQJ-UHFFFAOYSA-N;   SMILES=OC(=O)CC(S)C(O)=O;   alpha-mercaptosuccinic acid;   mercaptosuccinic acid;   monomercaptosuccinic acid
 xref: Beilstein:1099858;   CAS:70-49-5;   Gmelin:218084
 xref_mesh: MESH:C046062
 cyclic_relationship: is_conjugate_acid_of CHEBI:38708

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thiomalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G multiple interactions EXP [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein CTD PMID:16407272 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO 2-thiomalic acid results in decreased activity of GPX1 protein CTD PMID:21892612 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            anti-ulcer drug 777
              succinic acid 220
                thiomalic acid 3
                  (R)-thiomalic acid 0
                  (S)-thiomalic acid 0
                  aurothiomalic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      dicarboxylic acids and O-substituted derivatives 10300
                                        dicarboxylic acid 10292
                                          alpha,omega-dicarboxylic acid 2784
                                            succinic acid 220
                                              thiomalic acid 3
                                                (R)-thiomalic acid 0
                                                (S)-thiomalic acid 0
                                                aurothiomalic acid + 0
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