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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isocarbophos
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Accession:CHEBI:38704 term browser browse the term
Definition:A salicylate that has formula C11H16NO4PS.
Synonyms:exact_synonym: propan-2-yl 2-{[amino(methoxy)phosphorothioyl]oxy}benzoate
 related_synonym: Formula=C11H16NO4PS;   InChI=1S/C11H16NO4PS/c1-8(2)15-11(13)9-6-4-5-7-10(9)16-17(12,18)14-3/h4-8H,1-3H3,(H2,12,18);   InChIKey=YFVOXLJXJBQDEF-UHFFFAOYSA-N;   Isopropyl 2-((aminomethoxyphosphinothioyl)oxy)benzoate;   O-Methylphosphoramidothioate, O-ester with isopropyl salicylate;   SMILES=COP(N)(=S)Oc1ccccc1C(=O)OC(C)C;   isopropyl O-(methoxyaminothiophosphoryl)salicylate
 xref: CAS:24353-61-5
 xref_mesh: MESH:C549713
 xref: PPDB:987


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isocarbophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
isocarbophos metabolite results in decreased activity of ACHE protein
isocarbophos results in decreased activity of ACHE protein
CTD PMID:24752505 PMID:26818681 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isocarbophos analog results in increased expression of BAX protein CTD PMID:20688129 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO isocarbophos analog results in decreased expression of BCL2 protein CTD PMID:20688129 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage EXP isocarbophos results in increased cleavage of CASP3 protein CTD PMID:26818681 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO CYP2C19 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP isocarbophos results in increased expression of GJA1 protein CTD PMID:26818681 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of ICAM1 protein CTD PMID:26818681 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO isocarbophos analog results in increased phosphorylation of MAPK1 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK1 protein]
CTD PMID:20688129 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO isocarbophos analog results in increased phosphorylation of MAPK3 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK3 protein]
CTD PMID:20688129 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of VCAM1 protein CTD PMID:26818681 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        agrochemical 14503
          isocarbophos 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        aromatic carboxylic acid 10901
                                          benzoic acids 10870
                                            benzoic acid 3841
                                              hydroxybenzoic acid 3231
                                                monohydroxybenzoic acid 1266
                                                  salicylic acid 741
                                                    isopropyl salicylate 16
                                                      isocarbophos 12
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