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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flavan
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Accession:CHEBI:38691 term browser browse the term
Definition:The simplest member of the class of flavans that is chromane substituted by a phenyl group at position 2.
Synonyms:exact_synonym: 2-phenyl-3,4-dihydro-2H-chromene
 related_synonym: 2-Phenylchroman;   2-phenylchromane;   3,4-dihydro-2-phenyl-2H-1-benzopyran;   Formula=C15H14O;   InChI=1S/C15H14O/c1-2-6-12(7-3-1)15-11-10-13-8-4-5-9-14(13)16-15/h1-9,15H,10-11H2;   InChIKey=QOLIPNRNLBQTAU-UHFFFAOYSA-N;   SMILES=C1Cc2ccccc2OC1c1ccccc1
 alt_id: CHEBI:24039;   CHEBI:36097
 xref: Beilstein:383899;   CAS:494-12-2;   MetaCyc:CPD-13729;   Reaxys:383899;   Wikipedia:Flavan


show annotations for term's descendants           Sort by:
(+)-dihydromyricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] CTD PMID:21871475 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] CTD PMID:21871475 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] CTD PMID:21871475 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression
decreases activity		 ISO ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein		 CTD PMID:22251058 NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501 		JBrowse link
flavanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha fetoprotein affects binding ISO flavanone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Ar androgen receptor affects binding ISO flavanone binds to AR protein CTD PMID:14565775 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO flavanone results in increased expression of BAX protein CTD PMID:22056764 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone results in decreased activity of CASP3 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:22056764 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:22056764 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO flavanone results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:22056764 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO flavanone results in increased expression of CDKN1A protein CTD PMID:22056764 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO flavanone results in increased expression of CDKN1B protein CTD PMID:22056764 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO flavanone affects the localization of CYCS protein CTD PMID:22056764 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity		 ISO
EXP		 flavanone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
flavanone results in increased expression of CYP1A1 mRNA
flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
flavanone results in decreased activity of CYP1A1 protein		 CTD PMID:17090139 PMID:20930378 PMID:21053930 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO flavanone results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 flavanone binds to and results in decreased activity of CYP1B1 protein
flavanone analog results in increased expression of CYP1B1 mRNA		 CTD PMID:21053930 PMID:31621310 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO flavanone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] CTD PMID:21053930 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO flavanone results in increased expression of FAS mRNA CTD PMID:22056764 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand increases expression ISO flavanone results in increased expression of FASLG mRNA CTD PMID:22056764 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO flavanone results in decreased activity of MAOA protein CTD PMID:23009399 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO flavanone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO flavanone results in increased cleavage of PARP1 protein CTD PMID:22056764 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO flavanone results in increased expression of PPARG protein CTD PMID:22056764 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO flavanone results in increased expression of PTEN protein CTD PMID:22056764 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO flavanone results in decreased phosphorylation of RB1 protein CTD PMID:22056764 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO flavanone binds to SHBG protein CTD PMID:25349334 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO flavanone results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:22056764 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression EXP flavanone analog results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions		 EXP
ISO		 kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]		 CTD PMID:24997323 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP
ISO		 kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]		 CTD PMID:24997323 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP		 kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO
EXP		 kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein		 CTD PMID:24997323 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
liquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]		 CTD PMID:31589899 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO liquiritigenin results in increased expression of CXCL12 mRNA CTD PMID:28396216 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO liquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO liquiritigenin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases activity ISO liquiritigenin results in increased activity of ESR1 protein CTD PMID:28396216 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases activity ISO liquiritigenin results in increased activity of ESR2 protein CTD PMID:25106122 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
liquiritigenin results in increased expression of GCLC protein		 CTD PMID:29908794 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions		 ISO liquiritigenin results in increased expression of GCLM protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]		 CTD PMID:29908794 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] CTD PMID:31589899 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] CTD PMID:29908794 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions ISO
EXP		 liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]		 CTD PMID:31589899 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]		 CTD PMID:31589899 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases response to substance
multiple interactions		 EXP
ISO		 NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]		 CTD PMID:29908794 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]		 CTD PMID:31589899 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 EXP
ISO		 liquiritigenin results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]		 CTD PMID:26473469 PMID:29908794 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]		 CTD PMID:31589899 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 decreases activity EXP liquiritigenin results in decreased activity of TRPM3 protein CTD PMID:25361167 NCBI chr19:22,114,789...22,972,774
Ensembl chr19:22,116,410...22,972,774 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] CTD PMID:23183181 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions ISO liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
liquiritin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions EXP [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA CTD PMID:36008890 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions EXP [liquiritin co-treated with 1-Naphthylisothiocyanate] results in decreased expression of ABCC2 mRNA CTD PMID:36008890 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions EXP [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 mRNA CTD PMID:36008890 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions EXP [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA CTD PMID:36008890 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]		 CTD PMID:31589899 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
liquiritin results in increased expression of GCLC protein		 CTD PMID:29908794 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
liquiritin results in increased expression of GCLM protein		 CTD PMID:29908794 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP		 liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]		 CTD PMID:31589899 PMID:36008890 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 mRNA; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 protein]		 CTD PMID:29908794 PMID:36008890 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions EXP
ISO		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]		 CTD PMID:31589899 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein] CTD PMID:36008890 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]		 CTD PMID:31589899 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions EXP liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases response to substance		 ISO
EXP		 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
liquiritin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form results in decreased susceptibility to liquiritin		 CTD PMID:29908794 PMID:36008890 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]		 CTD PMID:31589899 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 mRNA		 CTD PMID:29908794 PMID:36008890 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein] CTD PMID:36008890 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]		 CTD PMID:31589899 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] CTD PMID:36008890 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 multiple interactions EXP liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:36008890 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein] CTD PMID:36008890 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions ISO liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
pinostrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of AARS1 mRNA CTD PMID:37777166 NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
decreases activity
decreases response to substance		 ISO [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to pinostrobin		 CTD PMID:37259354 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Acvr1 activin A receptor, type 1 increases expression ISO pinostrobin results in increased expression of ACVR1 mRNA CTD PMID:37777166 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Ahctf1 AT hook containing transcription factor 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of AHCTF1 protein CTD PMID:37164308 NCBI chr 1:179,572,469...179,631,580
Ensembl chr 1:179,572,459...179,631,245 		JBrowse link
G Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 increases expression ISO pinostrobin results in increased expression of AIFM3 mRNA CTD PMID:37777166 NCBI chr16:17,307,418...17,325,349
Ensembl chr16:17,307,475...17,325,349 		JBrowse link
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 increases expression ISO pinostrobin results in increased expression of AREL1 mRNA CTD PMID:37777166 NCBI chr12:84,964,914...85,017,674
Ensembl chr12:84,964,922...85,017,674 		JBrowse link
G Asns asparagine synthetase increases expression ISO pinostrobin results in increased expression of ASNS mRNA CTD PMID:37777166 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Atm ataxia telangiectasia mutated increases expression ISO pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein CTD PMID:37208425 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO pinostrobin results in increased expression of ATP5F1A mRNA CTD PMID:37777166 NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569 		JBrowse link
G Axl AXL receptor tyrosine kinase increases expression ISO pinostrobin results in increased expression of AXL mRNA CTD PMID:37777166 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pinostrobin results in increased expression of BAD mRNA CTD PMID:37777166 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pinostrobin results in increased expression of BAK1 mRNA CTD PMID:37164308 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]		 CTD PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO pinostrobin results in increased expression of BBC3 mRNA CTD PMID:37777166 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO pinostrobin results in decreased expression of BCL2 protein
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]		 CTD PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO pinostrobin results in increased expression of BCL2L11 mRNA CTD PMID:37777166 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Bcl2l2 BCL2-like 2 decreases expression ISO pinostrobin results in decreased expression of BCL2L2 mRNA CTD PMID:37164308 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Bmf BCL2 modifying factor increases expression ISO pinostrobin results in increased expression of BMF mRNA CTD PMID:37777166 NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 increases expression ISO pinostrobin results in increased expression of CALHM2 mRNA CTD PMID:37777166 NCBI chr19:47,120,671...47,126,733
Ensembl chr19:47,093,792...47,126,733 		JBrowse link
G Capn3 calpain 3 increases expression ISO pinostrobin results in increased expression of CAPN3 mRNA CTD PMID:37777166 NCBI chr 2:120,294,074...120,335,400
Ensembl chr 2:120,294,053...120,335,399 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein
pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein		 CTD PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases expression ISO pinostrobin results in increased expression of CASP8 mRNA CTD PMID:37208425 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases expression ISO pinostrobin results in increased expression of CASP9 mRNA CTD PMID:37208425 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] CTD PMID:37342552 PMID:37866152 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cbs cystathionine beta-synthase increases expression ISO pinostrobin results in increased expression of CBS mRNA CTD PMID:37777166 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO pinostrobin results in decreased expression of CCNE1 protein CTD PMID:37777166 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cd14 CD14 antigen increases expression ISO pinostrobin results in increased expression of CD14 mRNA CTD PMID:37777166 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd70 CD70 antigen increases expression ISO pinostrobin results in increased expression of CD70 mRNA CTD PMID:37777166 NCBI chr17:57,452,997...57,456,777
Ensembl chr17:57,452,997...57,456,777 		JBrowse link
G Cdc40 cell division cycle 40 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDC40 protein CTD PMID:37164308 NCBI chr10:40,707,617...40,759,139
Ensembl chr10:40,707,617...40,759,307 		JBrowse link
G Cdh1 cadherin 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDH1 protein CTD PMID:37164308 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein CTD PMID:37777166 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO pinostrobin results in increased expression of CDKN1B protein CTD PMID:37777166 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO pinostrobin results in increased expression of CEBPB mRNA CTD PMID:37777166 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Chac1 ChaC, cation transport regulator 1 increases expression ISO pinostrobin results in increased expression of CHAC1 mRNA CTD PMID:37777166 NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862 		JBrowse link
G Cideb cell death-inducing DNA fragmentation factor, alpha subunit-like effector B increases expression ISO pinostrobin results in increased expression of CIDEB mRNA CTD PMID:37777166 NCBI chr14:55,991,509...55,995,881
Ensembl chr14:55,991,507...55,995,915 		JBrowse link
G Cldn7 claudin 7 increases expression ISO pinostrobin results in increased expression of CLDN7 mRNA CTD PMID:37777166 NCBI chr11:69,855,605...69,858,712
Ensembl chr11:69,855,605...69,858,711 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression ISO pinostrobin results in decreased expression of CRELD2 protein CTD PMID:37164308 NCBI chr15:88,703,849...88,710,884
Ensembl chr15:88,703,849...88,710,886 		JBrowse link
G Cth cystathionine gamma lyase increases expression ISO pinostrobin results in increased expression of CTH mRNA CTD PMID:37777166 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein		 CTD PMID:37164308 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO pinostrobin results in increased expression of CXCR4 mRNA CTD PMID:37777166 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Dcps decapping enzyme, scavenger increases expression ISO pinostrobin results in increased expression of DCPS mRNA CTD PMID:37777166 NCBI chr 9:35,035,710...35,087,283
Ensembl chr 9:35,035,704...35,087,357 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pinostrobin results in increased expression of DDIT3 mRNA CTD PMID:37777166 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO pinostrobin results in increased expression of DDIT4 mRNA CTD PMID:37777166 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Dnase1 deoxyribonuclease I increases expression ISO pinostrobin results in increased expression of DNASE1 mRNA CTD PMID:37777166 NCBI chr16:3,855,007...3,857,888
Ensembl chr16:3,854,806...3,857,888 		JBrowse link
G Dnase2a deoxyribonuclease II alpha increases expression ISO pinostrobin results in increased expression of DNASE2 mRNA CTD PMID:37777166 NCBI chr 8:85,635,384...85,638,332
Ensembl chr 8:85,635,189...85,649,544 		JBrowse link
G Doc2b double C2, beta increases phosphorylation ISO pinostrobin results in increased phosphorylation of DOC2B protein CTD PMID:37164308 NCBI chr11:75,659,096...75,686,886
Ensembl chr11:75,659,792...75,686,875 		JBrowse link
G Elmo1 engulfment and cell motility 1 increases expression ISO pinostrobin results in increased expression of ELMO1 mRNA CTD PMID:37777166 NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression ISO pinostrobin results in increased expression of ERC1 mRNA CTD PMID:37777166 NCBI chr 6:119,547,757...119,830,985
Ensembl chr 6:119,547,757...119,825,128 		JBrowse link
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 increases expression ISO pinostrobin results in increased expression of ERCC2 mRNA CTD PMID:37777166 NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619 		JBrowse link
G Etv6 ets variant 6 increases expression ISO pinostrobin results in increased expression of ETV6 mRNA CTD PMID:37777166 NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121 		JBrowse link
G Fank1 fibronectin type 3 and ankyrin repeat domains 1 increases expression ISO pinostrobin results in increased expression of FANK1 mRNA CTD PMID:37777166 NCBI chr 7:133,378,594...133,483,261
Ensembl chr 7:133,378,590...133,483,261 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pinostrobin results in increased expression of FAS mRNA CTD PMID:37208425 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fbh1 F-box DNA helicase 1 increases expression ISO pinostrobin results in increased expression of FBH1 mRNA CTD PMID:37777166 NCBI chr 2:11,747,384...11,782,396
Ensembl chr 2:11,747,384...11,782,393 		JBrowse link
G Fcmr Fc fragment of IgM receptor increases expression ISO pinostrobin results in increased expression of FCMR mRNA CTD PMID:37777166 NCBI chr 1:130,793,514...130,808,528
Ensembl chr 1:130,793,406...130,808,528 		JBrowse link
G Fer1l4 fer-1 like family member 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of FER1L4 protein CTD PMID:37164308 NCBI chr 2:155,861,059...155,894,939
Ensembl chr 2:155,861,059...155,894,867 		JBrowse link
G Flcn folliculin increases expression ISO pinostrobin results in increased expression of FLCN mRNA CTD PMID:37777166 NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842 		JBrowse link
G Fmo5 flavin containing monooxygenase 5 decreases phosphorylation ISO pinostrobin results in decreased phosphorylation of FMO5 protein CTD PMID:37164308 NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598 		JBrowse link
G Foxa1 forkhead box A1 increases expression ISO pinostrobin results in increased expression of FOXA1 mRNA CTD PMID:37777166 NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702 		JBrowse link
G Foxo3 forkhead box O3 increases expression
multiple interactions		 ISO pinostrobin results in increased expression of FOXO3 mRNA
pinostrobin results in increased expression of and affects the localization of FOXO3 protein		 CTD PMID:37777166 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:37866152 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Fyn Fyn proto-oncogene increases expression ISO pinostrobin results in increased expression of FYN mRNA CTD PMID:37777166 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO pinostrobin results in increased expression of GADD45A mRNA CTD PMID:37777166 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Glb1 galactosidase, beta 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of GLB1 protein CTD PMID:37164308 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966 		JBrowse link
G Gm7030 predicted gene 7030 increases expression ISO pinostrobin results in increased expression of HLA-F mRNA CTD PMID:37777166 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317 		JBrowse link
G Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) increases expression ISO pinostrobin results in increased expression of GRINA mRNA CTD PMID:37777166 NCBI chr15:76,130,917...76,134,109
Ensembl chr15:76,130,964...76,134,104 		JBrowse link
G Grn granulin increases expression ISO pinostrobin results in increased expression of GRN mRNA CTD PMID:37777166 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:37342552 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] CTD PMID:37342552 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hip1 huntingtin interacting protein 1 increases expression ISO pinostrobin results in increased expression of HIP1 mRNA CTD PMID:37777166 NCBI chr 5:135,435,350...135,574,167
Ensembl chr 5:135,435,385...135,573,974 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pinostrobin results in increased expression of HMOX1 mRNA CTD PMID:37777166 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing increases expression ISO pinostrobin results in increased expression of HSH2D mRNA CTD PMID:37777166 NCBI chr 8:72,943,512...72,954,802
Ensembl chr 8:72,943,482...72,955,371 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO pinostrobin results in increased expression of ID3 mRNA CTD PMID:37777166 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066 		JBrowse link
G Ifi204 interferon activated gene 204 increases expression ISO pinostrobin results in increased expression of IFI16 mRNA CTD PMID:37777166 NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein] CTD PMID:38078205 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein] CTD PMID:37342552 PMID:37866152 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ing4 inhibitor of growth family, member 4 increases expression ISO pinostrobin results in increased expression of ING4 mRNA CTD PMID:37777166 NCBI chr 6:125,016,811...125,026,228
Ensembl chr 6:125,016,723...125,026,228 		JBrowse link
G Inhba inhibin beta-A increases expression ISO pinostrobin results in increased expression of INHBA mRNA CTD PMID:37777166 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206 		JBrowse link
G Ino80 INO80 complex subunit increases phosphorylation ISO pinostrobin results in increased phosphorylation of INO80 protein CTD PMID:37164308 NCBI chr 2:119,203,523...119,308,168
Ensembl chr 2:119,203,523...119,308,168 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression ISO pinostrobin results in increased expression of IRF7 mRNA CTD PMID:37777166 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Itgam integrin alpha M increases expression ISO pinostrobin results in increased expression of ITGAM mRNA CTD PMID:37777166 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itpk1 inositol 1,3,4-triphosphate 5/6 kinase increases expression ISO pinostrobin results in increased expression of ITPK1 mRNA CTD PMID:37777166 NCBI chr12:102,534,842...102,671,128
Ensembl chr12:102,534,841...102,671,189 		JBrowse link
G Kdm2b lysine (K)-specific demethylase 2B increases expression ISO pinostrobin results in increased expression of KDM2B mRNA CTD PMID:37777166 NCBI chr 5:123,008,727...123,127,333
Ensembl chr 5:123,008,728...123,127,886 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein] CTD PMID:37342552 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lgals2 lectin, galactose-binding, soluble 2 increases expression ISO pinostrobin results in increased expression of LGALS2 mRNA CTD PMID:37777166 NCBI chr15:78,735,060...78,739,729
Ensembl chr15:78,735,060...78,739,729 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:37866152 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO pinostrobin results in increased expression of MADD mRNA CTD PMID:37777166 NCBI chr 2:90,967,705...91,013,404
Ensembl chr 2:90,967,705...91,014,182 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO pinostrobin results in decreased expression of MCL1 mRNA CTD PMID:37164308 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mef2a myocyte enhancer factor 2A increases expression ISO pinostrobin results in increased expression of MEF2A mRNA CTD PMID:37777166 NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606 		JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO pinostrobin results in increased expression of MEF2D mRNA CTD PMID:37777166 NCBI chr 3:88,049,248...88,079,398
Ensembl chr 3:88,049,679...88,079,393 		JBrowse link
G Mir410 microRNA 410 multiple interactions
decreases expression		 ISO [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of MIR410 mRNA		 CTD PMID:37164308 NCBI chr12:109,710,149...109,710,229
Ensembl chr12:109,710,149...109,710,229 		JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of MRPL1 protein CTD PMID:37164308 NCBI chr 5:96,357,357...96,414,586
Ensembl chr 5:96,357,352...96,414,586 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO pinostrobin results in increased expression of MT3 mRNA CTD PMID:37777166 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO pinostrobin results in increased expression of MUTYH mRNA CTD PMID:37777166 NCBI chr 4:116,664,846...116,676,641
Ensembl chr 4:116,664,920...116,676,637 		JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 increases expression ISO pinostrobin results in increased expression of NAIP mRNA CTD PMID:37777166 NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO pinostrobin results in increased expression of NINJ1 mRNA CTD PMID:37777166 NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720 		JBrowse link
G Nisch nischarin increases expression ISO pinostrobin results in increased expression of NISCH mRNA CTD PMID:37777166 NCBI chr14:30,892,885...30,928,783
Ensembl chr14:30,892,887...30,938,903 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A increases expression ISO pinostrobin results in increased expression of NLRP1 mRNA CTD PMID:37777166 NCBI chr11:70,982,023...71,035,780
Ensembl chr11:70,983,062...71,035,530 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein] CTD PMID:37342552 PMID:37866152 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO pinostrobin results in increased expression of NOS3 mRNA CTD PMID:37777166 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO pinostrobin results in increased expression of NR4A1 mRNA CTD PMID:37777166 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO pinostrobin results in increased expression of NTSR1 mRNA CTD PMID:37777166 NCBI chr 2:180,141,769...180,186,772
Ensembl chr 2:180,141,769...180,186,773 		JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 increases expression ISO pinostrobin results in increased expression of P2RX1 mRNA CTD PMID:37777166 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 increases expression ISO pinostrobin results in increased expression of P2RX7 mRNA CTD PMID:37777166 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent increases expression ISO pinostrobin results in increased expression of PDE1B mRNA CTD PMID:37777166 NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479 		JBrowse link
G Peli3 pellino 3 increases expression ISO pinostrobin results in increased expression of PELI3 mRNA CTD PMID:37777166 NCBI chr19:4,979,745...4,993,155
Ensembl chr19:4,979,745...4,993,155 		JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 increases expression ISO pinostrobin results in increased expression of PHLDA3 mRNA CTD PMID:37777166 NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874 		JBrowse link
G Pim2 proviral integration site 2 increases expression ISO pinostrobin results in increased expression of PIM2 mRNA CTD PMID:37777166 NCBI chr  X:7,744,545...7,749,671
Ensembl chr  X:7,744,501...7,749,671 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO pinostrobin results in increased expression of PLAUR mRNA CTD PMID:37777166 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO pinostrobin results in increased expression of PLD1 protein CTD PMID:37164308 NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511 		JBrowse link
G Plec plectin decreases expression ISO pinostrobin results in decreased expression of PLEC protein CTD PMID:37164308 NCBI chr15:76,055,174...76,115,578
Ensembl chr15:76,055,174...76,116,774 		JBrowse link
G Plxnd1 plexin D1 increases expression ISO pinostrobin results in increased expression of PLXND1 mRNA CTD PMID:37777166 NCBI chr 6:115,931,772...115,972,300
Ensembl chr 6:115,931,772...115,971,966 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO pinostrobin results in increased expression of PMP22 mRNA CTD PMID:37777166 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373 		JBrowse link
G Pou3f3 POU domain, class 3, transcription factor 3 increases expression ISO pinostrobin results in increased expression of POU3F3 mRNA CTD PMID:37777166 NCBI chr 1:42,734,928...42,739,370
Ensembl chr 1:42,734,085...42,742,336 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO pinostrobin results in increased expression of PPARA mRNA CTD PMID:37777166 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein] CTD PMID:37342552 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta increases expression ISO pinostrobin results in increased expression of PTK2B mRNA CTD PMID:37777166 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of QARS1 mRNA CTD PMID:37777166 NCBI chr 9:108,385,204...108,393,140
Ensembl chr 9:108,384,905...108,393,140 		JBrowse link
G Ret ret proto-oncogene increases expression ISO pinostrobin results in increased expression of RET mRNA CTD PMID:37777166 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
G Rnf130 ring finger protein 130 increases expression ISO pinostrobin results in increased expression of RNF130 mRNA CTD PMID:37777166 NCBI chr11:49,916,158...50,016,546
Ensembl chr11:49,916,173...50,016,546 		JBrowse link
G Rnf216 ring finger protein 216 increases expression ISO pinostrobin results in increased expression of RNF216 mRNA CTD PMID:37777166 NCBI chr 5:142,976,648...143,098,793
Ensembl chr 5:142,976,648...143,098,749 		JBrowse link
G Rtkn rhotekin increases expression ISO pinostrobin results in increased expression of RTKN mRNA CTD PMID:37777166 NCBI chr 6:83,112,485...83,129,560
Ensembl chr 6:83,112,444...83,129,560 		JBrowse link
G Scfd2 Sec1 family domain containing 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCFD2 protein CTD PMID:37164308 NCBI chr 5:74,365,477...74,692,436
Ensembl chr 5:74,365,477...74,692,420 		JBrowse link
G Scn2a sodium channel, voltage-gated, type II, alpha increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCN2A protein CTD PMID:37164308 NCBI chr 2:65,451,108...65,597,791
Ensembl chr 2:65,451,115...65,597,791 		JBrowse link
G Scx scleraxis scleraxis bHLH transcription factor increases expression ISO pinostrobin results in increased expression of SCX mRNA CTD PMID:37777166 NCBI chr15:76,341,594...76,343,668
Ensembl chr15:76,341,652...76,343,658 		JBrowse link
G Selenos selenoprotein S increases expression ISO pinostrobin results in increased expression of SELENOS mRNA CTD PMID:37777166 NCBI chr 7:65,729,397...65,739,153
Ensembl chr 7:65,729,397...65,739,153 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 increases expression ISO pinostrobin results in increased expression of SERPINF1 mRNA CTD PMID:37777166 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Sfrp5 secreted frizzled-related sequence protein 5 increases expression
increases phosphorylation
multiple interactions		 ISO pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein
pinostrobin results in increased phosphorylation of SFRP5 protein
pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]		 CTD PMID:37164308 NCBI chr19:42,186,410...42,190,691
Ensembl chr19:42,186,410...42,190,691 		JBrowse link
G Sharpin SHANK-associated RH domain interacting protein increases expression ISO pinostrobin results in increased expression of SHARPIN mRNA CTD PMID:37777166 NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311 		JBrowse link
G Shisa5 shisa family member 5 increases expression ISO pinostrobin results in increased expression of SHISA5 mRNA CTD PMID:37777166 NCBI chr 9:108,867,635...108,886,860
Ensembl chr 9:108,867,633...108,886,845 		JBrowse link
G Slc10a5 solute carrier family 10 (sodium/bile acid cotransporter family), member 5 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SLC10A5 protein CTD PMID:37164308 NCBI chr 3:10,396,794...10,400,716
Ensembl chr 3:10,396,794...10,400,716 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 increases expression ISO pinostrobin results in increased expression of SLC46A2 mRNA CTD PMID:37777166 NCBI chr 4:59,905,899...59,915,056
Ensembl chr 4:59,905,126...59,915,056 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO pinostrobin results in increased expression of SLC7A11 mRNA CTD PMID:37777166 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO pinostrobin results in increased expression of SLCO5A1 protein CTD PMID:37164308 NCBI chr 1:12,936,773...13,063,043
Ensembl chr 1:12,936,773...13,062,874 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO pinostrobin results in increased expression of SMAD3 mRNA CTD PMID:37777166 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smim7 small integral membrane protein 7 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SMIM7 protein CTD PMID:37164308 NCBI chr 8:73,319,042...73,324,892
Ensembl chr 8:73,319,032...73,324,932 		JBrowse link
G Stap2 signal transducing adaptor family member 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of STAP2 protein CTD PMID:37164308 NCBI chr17:56,304,074...56,315,558
Ensembl chr17:56,304,077...56,312,584 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO pinostrobin results in increased expression of STAR mRNA CTD PMID:37777166 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression ISO pinostrobin results in increased expression of STXBP1 mRNA CTD PMID:37777166 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257 		JBrowse link
G Sycp2l synaptonemal complex protein 2-like increases expression ISO pinostrobin results in increased expression of SYCP2L mRNA CTD PMID:37777166 NCBI chr13:41,267,895...41,327,827
Ensembl chr13:41,267,783...41,327,827 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression ISO pinostrobin results in increased expression of TAF10 mRNA CTD PMID:37777166 NCBI chr 7:105,392,101...105,393,550
Ensembl chr 7:105,388,600...105,393,568 		JBrowse link
G Tcirg1 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 increases expression ISO pinostrobin results in increased expression of TCIRG1 mRNA CTD PMID:37777166 NCBI chr19:3,946,050...3,957,717
Ensembl chr19:3,946,050...3,957,133 		JBrowse link
G Tmem109 transmembrane protein 109 increases expression ISO pinostrobin results in increased expression of TMEM109 mRNA CTD PMID:37777166 NCBI chr19:10,848,021...10,859,107
Ensembl chr19:10,848,024...10,859,365 		JBrowse link
G Tmem39a transmembrane protein 39a increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMEM39A protein CTD PMID:37164308 NCBI chr16:38,379,060...38,412,524
Ensembl chr16:38,379,060...38,412,524 		JBrowse link
G Tmem79 transmembrane protein 79 increases expression ISO pinostrobin results in increased expression of TMEM79 mRNA CTD PMID:37777166 NCBI chr 3:88,236,351...88,241,761
Ensembl chr 3:88,235,962...88,243,455 		JBrowse link
G Tmprss4 transmembrane protease, serine 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMPRSS4 protein CTD PMID:37164308 NCBI chr 9:45,084,024...45,115,417
Ensembl chr 9:45,084,024...45,115,390 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator multiple interactions ISO pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein] CTD PMID:37866152 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709 		JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 increases expression ISO pinostrobin results in increased expression of TNFSF14 mRNA CTD PMID:37777166 NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177 		JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 increases expression ISO pinostrobin results in increased expression of TNFSF9 mRNA CTD PMID:37777166 NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO pinostrobin results in increased expression of TRAP1 mRNA CTD PMID:37777166 NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO pinostrobin results in increased expression of TRIB3 mRNA CTD PMID:37777166 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO pinostrobin results in increased expression of TP53 mRNA CTD PMID:37208425 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 increases expression ISO pinostrobin results in increased expression of TRPM2 mRNA CTD PMID:37777166 NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO pinostrobin results in increased expression of TRPV1 mRNA CTD PMID:37777166 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO pinostrobin results in increased expression of VEGFA mRNA CTD PMID:37777166 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO pinostrobin results in increased expression of XBP1 mRNA CTD PMID:37777166 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
G Zfp746 zinc finger protein 746 increases expression ISO pinostrobin results in increased expression of ZNF746 mRNA CTD PMID:37777166 NCBI chr 6:48,039,325...48,064,275
Ensembl chr 6:48,039,329...48,063,527 		JBrowse link
sophoranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO sophoranone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO sophoranone results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    chemical entity 22193
      atom 22186
        nonmetal atom 22071
          oxygen atom 21425
            oxygen molecular entity 21425
              flavonoids 11805
                flavonoid 7262
                  flavans 3651
                    flavan 213
                      (2R)-flavan + 0
                      (2S)-flavan + 0
                      7,4'-di-O-galloyltricetiflavan 0
                      7-O-galloyltricetiflavan 0
                      flavanone + 207
                      flavanonol + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                organic heterocyclic compound 20342
                                  oxacycle 18841
                                    benzopyran 12214
                                      1-benzopyran 11971
                                        flavonoid 7262
                                          flavans 3651
                                            flavan 213
                                              (2R)-flavan + 0
                                              (2S)-flavan + 0
                                              7,4'-di-O-galloyltricetiflavan 0
                                              7-O-galloyltricetiflavan 0
                                              flavanone + 207
                                              flavanonol + 6
paths to the root