CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: monohydroxyflavone
Accession: CHEBI:38687
browse the term
Definition: A hydroxyflavone carrying a single hydroxy substituent.
Synonyms: related_synonym: monohydroxyflavones
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Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]
CTD
PMID:21871475
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]
CTD
PMID:21871475
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]
CTD
PMID:21871475
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
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Pdgfrb
platelet derived growth factor receptor beta
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]
CTD
PMID:21871475
NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
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Plcg1
phospholipase C, gamma 1
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]
CTD
PMID:21871475
NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
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Sphk1
sphingosine kinase 1
decreases expression decreases activity
ISO
ampelopsin results in decreased expression of SPHK1 protein ampelopsin results in decreased activity of SPHK1 protein
CTD
PMID:22251058
NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions decreases activity
ISO
taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione] taxifolin results in decreased activity of ABCC1 protein
CTD
PMID:15041478
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Afp
alpha-fetoprotein
affects binding
EXP
taxifolin binds to AFP protein
CTD
PMID:23013281 PMID:25349334
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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Agt
angiotensinogen
decreases expression
ISO
taxifolin results in decreased expression of AGT protein modified form
CTD
PMID:24269735
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]
CTD
PMID:29584932
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Apoa1
apolipoprotein A1
increases expression
ISO
taxifolin results in increased expression of APOA1 protein
CTD
PMID:11108730
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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Apob
apolipoprotein B
decreases secretion decreases expression
ISO
taxifolin results in decreased secretion of APOB protein taxifolin results in decreased expression of APOB protein
CTD
PMID:11108730 PMID:15380446
NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]
CTD
PMID:32525071
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
decreases activity
EXP
taxifolin results in decreased activity of CASP3 protein
CTD
PMID:24269735
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp9
caspase 9
decreases activity
EXP
taxifolin results in decreased activity of CASP9 protein
CTD
PMID:24269735
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]
CTD
PMID:30372826 PMID:32525071
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccna1
cyclin A1
decreases expression
ISO
taxifolin results in decreased expression of CCNA1 mRNA
CTD
PMID:17541156
NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
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Cdc25a
cell division cycle 25A
decreases expression
ISO
taxifolin results in decreased expression of CDC25A mRNA
CTD
PMID:17541156
NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]
CTD
PMID:30372826
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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Cycs
cytochrome c, somatic
affects localization
EXP
taxifolin affects the localization of CYCS protein
CTD
PMID:24269735
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]
CTD
PMID:32525071
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]
CTD
PMID:22422552 PMID:29584932
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
taxifolin results in decreased expression of CYP2E1 mRNA
CTD
PMID:17541156
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Dcc
DCC netrin 1 receptor
increases expression
ISO
taxifolin results in increased expression of DCC mRNA
CTD
PMID:17541156
NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
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Egf
epidermal growth factor
decreases expression
ISO
taxifolin results in decreased expression of EGF mRNA
CTD
PMID:17541156
NCBI chr 2:68,820,616...68,895,537
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Fgf18
fibroblast growth factor 18
decreases expression
ISO
taxifolin results in decreased expression of FGF18 mRNA
CTD
PMID:17541156
NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
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Fgf3
fibroblast growth factor 3
decreases expression
ISO
taxifolin results in decreased expression of FGF3 mRNA
CTD
PMID:17541156
NCBI chr 1:218,003,018...218,006,942
Ensembl chr 1:218,003,018...218,006,942
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Gas6
growth arrest specific 6
increases expression
ISO
taxifolin results in increased expression of GAS6 mRNA
CTD
PMID:17541156
NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
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Gdf15
growth differentiation factor 15
increases expression
ISO
taxifolin results in increased expression of GDF15 mRNA
CTD
PMID:17541156
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
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Gpx1
glutathione peroxidase 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein]
CTD
PMID:32525071
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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Gstm1
glutathione S-transferase mu 1
increases expression
ISO
taxifolin results in increased expression of GSTM1 mRNA
CTD
PMID:17541156
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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Hmox1
heme oxygenase 1
increases expression multiple interactions decreases expression
ISO
taxifolin results in increased expression of HMOX1 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]
CTD
PMID:16799064 PMID:31152760
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]
CTD
PMID:32525071
NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
CTD
PMID:12044887 PMID:19103272
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Ifng
interferon gamma
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]
CTD
PMID:12044887 PMID:19103272 PMID:31152760
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Insl3
insulin-like 3
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]
CTD
PMID:32525071
NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
taxifolin results in decreased expression of JUN mRNA
CTD
PMID:17541156
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
CTD
PMID:12044887
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mttp
microsomal triglyceride transfer protein
decreases activity
ISO
taxifolin results in decreased activity of MTTP protein
CTD
PMID:15380446
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
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Nfe2l2
nuclear factor, erythroid 2-like 2
increases expression decreases expression multiple interactions
ISO
taxifolin results in increased expression of NFE2L2 protein taxifolin results in decreased expression of NFE2L2 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]
CTD
PMID:16799064 PMID:31152760
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases activity increases expression
ISO
taxifolin results in increased activity of NQO1 protein taxifolin results in increased expression of NQO1 mRNA
CTD
PMID:17541156
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Pdgfb
platelet derived growth factor subunit B
decreases expression
ISO
taxifolin results in decreased expression of PDGFB mRNA
CTD
PMID:17541156
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
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Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]
CTD
PMID:32525071
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD
PMID:21341175
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rasa1
RAS p21 protein activator 1
decreases expression
ISO
taxifolin results in decreased expression of RASA1 mRNA
CTD
PMID:17541156
NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
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Sirt1
sirtuin 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]
CTD
PMID:32525071
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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Sod1
superoxide dismutase 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein]
CTD
PMID:32525071
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sod2
superoxide dismutase 2
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]
CTD
PMID:32525071
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Sox9
SRY-box transcription factor 9
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA]
CTD
PMID:32525071
NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]
CTD
PMID:12044887
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Tnf
tumor necrosis factor
multiple interactions
ISO
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
CTD
PMID:31152760
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Traf3
Tnf receptor-associated factor 3
increases expression
ISO
taxifolin results in increased expression of TRAF3 mRNA
CTD
PMID:17541156
NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
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Txnrd1
thioredoxin reductase 1
increases expression decreases activity
ISO EXP
taxifolin results in increased expression of TXNRD1 mRNA taxifolin results in decreased activity of TXNRD1 protein modified form
CTD
PMID:16618767 PMID:17541156
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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Ucp1
uncoupling protein 1
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]
CTD
PMID:30372826
NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression multiple interactions
ISO
taxifolin results in increased expression of UGT1A1 mRNA AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]
CTD
PMID:29584932
NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Xdh
xanthine dehydrogenase
multiple interactions
ISO
taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]
CTD
PMID:19555678
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Xpa
XPA, DNA damage recognition and repair factor
increases expression
ISO
taxifolin results in increased expression of XPA mRNA
CTD
PMID:17541156
NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
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Xrcc4
X-ray repair cross complementing 4
increases expression
ISO
taxifolin results in increased expression of XRCC4 mRNA
CTD
PMID:17541156
NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]
CTD
PMID:29471006
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:29471006
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:29471006
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:29471006
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp9
caspase 9
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD
PMID:29471006
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:29471006
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]
CTD
PMID:29471006
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]
CTD
PMID:29471006
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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Il1b
interleukin 1 beta
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:29471006
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD
PMID:29471006
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29471006
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29471006
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Nfe2l2
nuclear factor, erythroid 2-like 2
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
CTD
PMID:29471006
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29471006
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD
PMID:29471006
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
CTD
PMID:29471006
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD
PMID:29471006
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD
PMID:29471006
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:29471006
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Tnf
tumor necrosis factor
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD
PMID:29471006
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29471006
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
3-hydroxyflavone results in increased expression of ABCB1 mRNA
CTD
PMID:26238175
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
3-hydroxyflavone results in decreased activity of CYP1A1 protein
CTD
PMID:21053930 PMID:31655123
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
3-hydroxyflavone results in decreased activity of CYP1A2 protein
CTD
PMID:21053930 PMID:29753067
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
3-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein
CTD
PMID:21053930
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases expression increases activity decreases activity multiple interactions
ISO
3-hydroxyflavone results in increased expression of CYP3A4 mRNA 3-hydroxyflavone results in increased activity of CYP3A4 protein 3-hydroxyflavone results in decreased activity of CYP3A4 protein [3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD
PMID:21053930 PMID:26238175 PMID:31756459
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
ISO
3-hydroxyflavone results in increased expression of CYP3A5 mRNA
CTD
PMID:26238175
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
G
Epcam
epithelial cell adhesion molecule
decreases expression
ISO
3-hydroxyflavone results in decreased expression of EPCAM protein
CTD
PMID:27600294
NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
G
Fn1
fibronectin 1
decreases expression
ISO
3-hydroxyflavone results in decreased expression of FN1 protein
CTD
PMID:27600294
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
3-hydroxyflavone results in increased expression of HMOX1 mRNA; 3-hydroxyflavone results in increased expression of HMOX1 protein Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
CTD
PMID:14563492
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Igf1
insulin-like growth factor 1
multiple interactions
ISO
3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17458902
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Irs1
insulin receptor substrate 1
multiple interactions
ISO
3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]
CTD
PMID:17458902
NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]
CTD
PMID:17458902
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation multiple interactions
ISO
3-hydroxyflavone results in decreased phosphorylation of MAPK1 protein 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]
CTD
PMID:17458902 PMID:27600294
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation multiple interactions
ISO
3-hydroxyflavone results in decreased phosphorylation of MAPK3 protein 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17458902 PMID:27600294
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Mmp2
matrix metallopeptidase 2
decreases expression
ISO
3-hydroxyflavone results in decreased expression of MMP2 protein
CTD
PMID:27600294
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
G
Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
3-hydroxyflavone promotes the reaction [NCOA1 protein binds to NR1I2 protein]
CTD
PMID:26238175
NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
3-hydroxyflavone promotes the reaction [NCOA2 protein binds to NR1I2 protein]
CTD
PMID:26238175
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
G
Ncoa3
nuclear receptor coactivator 3
multiple interactions
ISO
3-hydroxyflavone promotes the reaction [NCOA3 protein binds to NR1I2 protein]
CTD
PMID:26238175
NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
CTD
PMID:14563492
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO EXP
3-hydroxyflavone binds to and results in increased activity of NR1I2 protein; 3-hydroxyflavone promotes the reaction [NCOA1 protein binds to NR1I2 protein]; 3-hydroxyflavone promotes the reaction [NCOA2 protein binds to NR1I2 protein]; 3-hydroxyflavone promotes the reaction [NCOA3 protein binds to NR1I2 protein] 3-hydroxyflavone results in increased activity of NR1I2 protein
CTD
PMID:26238175
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
G
Pkm
pyruvate kinase M1/2
multiple interactions
ISO
3-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]
CTD
PMID:25388478
NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
G
Plau
plasminogen activator, urokinase
decreases expression
ISO
3-hydroxyflavone results in decreased expression of PLAU protein
CTD
PMID:27600294
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
G
Ptk2
protein tyrosine kinase 2
decreases phosphorylation
ISO
3-hydroxyflavone results in decreased phosphorylation of PTK2 protein
CTD
PMID:27600294
NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
G
Rhoa
ras homolog family member A
decreases expression
ISO
3-hydroxyflavone results in decreased expression of RHOA protein
CTD
PMID:27600294
NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
G
Snai2
snail family transcriptional repressor 2
decreases expression
ISO
3-hydroxyflavone results in decreased expression of SNAI2 protein
CTD
PMID:27600294
NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases phosphorylation
ISO
3-hydroxyflavone results in decreased phosphorylation of SRC protein
CTD
PMID:27600294
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
G
Vim
vimentin
decreases expression
ISO
3-hydroxyflavone results in decreased expression of VIM protein
CTD
PMID:27600294
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
gardenin B results in decreased expression of BCL2 protein
CTD
PMID:27423764
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp2
caspase 2
multiple interactions
ISO
gardenin B results in increased cleavage of and results in increased activity of CASP2 protein
CTD
PMID:27423764
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
G
Casp3
caspase 3
multiple interactions
ISO
gardenin B results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:27423764
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp8
caspase 8
multiple interactions
ISO
gardenin B results in increased cleavage of and results in increased activity of CASP8 protein
CTD
PMID:27423764
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Casp9
caspase 9
multiple interactions
ISO
gardenin B results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:27423764
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
gardenin B results in increased cleavage of PARP1 protein
CTD
PMID:27423764
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]
CTD
PMID:29471006
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:29471006
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:29471006
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:29471006
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp9
caspase 9
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD
PMID:29471006
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Cat
catalase
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:29471006
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]
CTD
PMID:29471006
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]
CTD
PMID:29471006
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
G
Il1b
interleukin 1 beta
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:29471006
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il6
interleukin 6
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD
PMID:29471006
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29471006
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29471006
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Nfe2l2
nuclear factor, erythroid 2-like 2
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
CTD
PMID:29471006
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29471006
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD
PMID:29471006
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
CTD
PMID:29471006
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD
PMID:29471006
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD
PMID:29471006
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:29471006
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Tnf
tumor necrosis factor
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein] astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
CTD
PMID:29471006
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Tp53
tumor protein p53
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29471006
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Abcg2
ATP binding cassette subfamily G member 2
decreases activity
ISO
tectochrysin results in decreased activity of ABCG2 protein
CTD
PMID:15930306
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19875
chemical entity
19875
molecular entity
19872
polyatomic entity
19786
heteroatomic molecular entity
19711
hydroxides
19139
organic hydroxy compound
18694
hydroxyflavone
4160
monohydroxyflavone
92
2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone
0
2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
0
4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)isovitexin
0
4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin
0
5-hydroxy-3,3',4',7-tetramethoxyflavone
0
5-hydroxy-7,2',4',5'-tetramethoxyflavone
0
6-hydroxy-2'-methoxyflavone
0
6-hydroxy-4',5,7-trimethoxyflavone
0
7-hydroxy-5-methoxy-6,8-dimethylflavone
0
acacetin-7-O-beta-D-galactopyranoside
0
apigenin 7,4'-dimethyl ether
0
combretol
0
diandraflavone
0
diplotrin B
0
diplotrin C
0
flavonol +
89
gardenin B
6
oroxylin A 7-O-beta-D-glucuronide
0
tectochrysin
1
tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside
0
tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside
0
wogonin 7-O-beta-D-glucuronide
0
Path 2
CHEBI ontology
19875
subatomic particle
19873
composite particle
19873
hadron
19873
baryon
19873
nucleon
19873
atomic nucleus
19873
atom
19873
main group element atom
19763
p-block element atom
19763
carbon group element atom
19668
carbon atom
19657
organic molecular entity
19657
organic molecule
19586
organic cyclic compound
19395
organic heterocyclic compound
18511
oxacycle
17301
benzopyran
10163
1-benzopyran
9879
flavonoid
6380
flavones
4172
hydroxyflavone
4160
monohydroxyflavone
92
2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone
0
2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
0
4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)isovitexin
0
4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin
0
5-hydroxy-3,3',4',7-tetramethoxyflavone
0
5-hydroxy-7,2',4',5'-tetramethoxyflavone
0
6-hydroxy-2'-methoxyflavone
0
6-hydroxy-4',5,7-trimethoxyflavone
0
7-hydroxy-5-methoxy-6,8-dimethylflavone
0
acacetin-7-O-beta-D-galactopyranoside
0
apigenin 7,4'-dimethyl ether
0
combretol
0
diandraflavone
0
diplotrin B
0
diplotrin C
0
flavonol +
89
gardenin B
6
oroxylin A 7-O-beta-D-glucuronide
0
tectochrysin
1
tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside
0
tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside
0
wogonin 7-O-beta-D-glucuronide
0