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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrahydroxyflavone
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Accession:CHEBI:38684 term browser browse the term
Definition:Any hydroxyflavone carrying four hydroxy substituents.
Synonyms:related_synonym: tetrahydroxyflavones
 alt_id: CHEBI:26924;   CHEBI:27117


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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Il6 interleukin 6 multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr 8:45,069,107...45,089,233
Ensembl chr 8:45,069,137...45,088,506
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 9:15,862,614...15,874,556
Ensembl chr 9:15,824,528...15,874,556
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
6-hydroxyluteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases chemical synthesis
ISO [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CYP1A1 protein results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases chemical synthesis
multiple interactions
ISO CYP1B1 protein results in increased chemical synthesis of 6-hydroxyluteolin
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanogenesis associated transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 6:97,807,002...98,021,360
Ensembl chr 6:97,807,052...98,021,349
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA
CTD PMID:27287415 NCBI chr 7:87,424,771...87,493,512
Ensembl chr 7:87,424,771...87,493,512
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 4:80,834,123...80,851,736
Ensembl chr 4:80,834,123...80,851,719
JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868 PMID:21482471 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Pkm pyruvate kinase, muscle increases activity ISO diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr 6:141,805,438...141,856,284
Ensembl chr 6:141,805,440...141,856,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP
ISO
Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647 PMID:32061149 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045 PMID:32061149 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045 PMID:32061149 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045 PMID:32061149 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha fetoprotein affects binding ISO fisetin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases localization ISO fisetin results in increased localization of AIFM1 protein CTD PMID:28181380 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO fisetin results in increased phosphorylation of AKT1 protein
fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
CTD PMID:20153296 PMID:25428606 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions EXP fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; fisetin results in decreased stability of and results in decreased expression of AR protein
fisetin results in decreased expression of AR mRNA
CTD PMID:18922931 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO fisetin results in increased expression of ATF6 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein]
CTD PMID:28181380 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein] CTD PMID:28181380 NCBI chr17:34,647,146...34,655,074
Ensembl chr17:34,647,146...34,655,074
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein CTD PMID:21216935 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
affects expression
ISO
EXP
fisetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
fisetin results in increased expression of BAX protein
fisetin inhibits the reaction [Lead results in increased expression of BAX protein]
fisetin affects the expression of BAX protein
[fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; U 0126 inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein]
CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
fisetin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
fisetin inhibits the reaction [Lead results in decreased expression of BCL2 protein]
fisetin results in decreased expression of BCL2 protein
[fisetin co-treated with Paclitaxel] results in increased expression of BCL2 mRNA
CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31539617 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO fisetin results in decreased expression of BCL2L1 protein
[pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]
CTD PMID:31044527 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of BDNF protein] CTD PMID:30890323 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP fisetin promotes the reaction [Lead results in increased expression of BECN1 protein] CTD PMID:31539617 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases cleavage
ISO [Cisplatin co-treated with fisetin] results in increased cleavage of BID protein
fisetin affects the expression of BID protein
fisetin results in increased cleavage of BID protein
CTD PMID:21216935 PMID:28181380 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Cisplatin co-treated with fisetin] results in decreased expression of BIRC5 protein CTD PMID:21216935 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Capn1 calpain 1 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN1 protein] CTD PMID:28181380 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
ISO fisetin results in increased expression of CAPN2 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN2 protein]
CTD PMID:28181380 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Casp12 caspase 12 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP12 protein] CTD PMID:28181380 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased activity of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP3 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP3 protein; [fisetin co-treated with Paclitaxel] results in increased expression of CASP3 mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Lead results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD PMID:21216935 PMID:21964635 PMID:22931364 PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP4 protein] CTD PMID:28181380 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein] CTD PMID:21216935 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein; fisetin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21216935 PMID:21964635 PMID:28181380 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP9 protein; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin results in increased cleavage of and results in increased activity of CASP9 protein
fisetin results in increased activity of CASP9 protein
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD PMID:21216935 PMID:25184746 PMID:28181380 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:25184746 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein] CTD PMID:31044527 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO fisetin results in decreased expression of CCNA2 protein CTD PMID:28181380 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein
fisetin results in decreased expression of CCNB1 protein
CTD PMID:21216935 PMID:28181380 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd44 CD44 antigen decreases expression ISO fisetin results in decreased expression of CD44 protein CTD PMID:30802432 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO fisetin results in decreased expression of CDC25C protein CTD PMID:28181380 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO fisetin results in increased expression of CDH1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of CDH1 protein]
CTD PMID:30802432 PMID:31606474 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:31606474 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO fisetin results in decreased expression of CDK1 protein CTD PMID:28181380 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO fisetin results in decreased expression of CDK2 protein CTD PMID:28181380 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO [Cisplatin co-treated with fisetin] results in increased expression of CDKN1A protein
fisetin results in increased expression of CDKN1A protein
CTD PMID:21216935 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO fisetin results in increased expression of CHEK2 protein CTD PMID:28181380 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cplx2 complexin 2 multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 NCBI chr13:54,301,964...54,383,923
Ensembl chr13:54,371,349...54,383,917
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP fisetin inhibits the reaction [Lead results in decreased phosphorylation of CREB1 protein] CTD PMID:31539617 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression
multiple interactions
ISO fisetin results in decreased expression of CTNNB1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CTNNB1 protein]
CTD PMID:30802432 PMID:31606474 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CXCL8 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of CXCL8 protein]; fisetin inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CXCL8 mRNA] CTD PMID:17884996 PMID:18958421 PMID:22931364 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA] CTD PMID:25184746 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO fisetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO fisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA] CTD PMID:23524313 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein] CTD PMID:28181380 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Ddn dendrin multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of DDN mRNA] CTD PMID:30890323 NCBI chr15:98,803,782...98,807,925
Ensembl chr15:98,803,777...98,809,490
JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases activity ISO fisetin results in increased activity of DIO2 protein CTD PMID:17327447 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP fisetin inhibits the reaction [Lead results in decreased expression of DLG4 protein] CTD PMID:31539617 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR protein modified form] CTD PMID:31606474 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein CTD PMID:28181380 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Endog endonuclease G increases localization ISO fisetin results in increased localization of ENDOG protein CTD PMID:28181380 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO fisetin results in decreased phosphorylation of and results in increased degradation of ERBB2 protein CTD PMID:30431692 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO fisetin results in decreased expression of ERBB3 protein CTD PMID:30431692 NCBI chr10:128,567,523...128,589,635
Ensembl chr10:128,567,523...128,589,652
JBrowse link
G Exoc8 exocyst complex component 8 multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of EXOC8 mRNA] CTD PMID:30890323 NCBI chr 8:124,890,299...124,897,705
Ensembl chr 8:124,893,108...124,897,705
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
increases expression
ISO [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein
fisetin results in increased expression of FASLG protein
CTD PMID:21216935 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO fisetin results in increased expression of and affects the localization of FOS protein CTD PMID:31044527 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gdnf glial cell line derived neurotrophic factor multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of GDNF protein] CTD PMID:30890323 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in increased expression of GFAP protein] CTD PMID:30890323 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GSK3B protein modified form] CTD PMID:31606474 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:25184746 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases expression
increases activity
ISO cobaltous chloride promotes the reaction [fisetin results in increased activity of HIF1A protein]; fisetin promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; fisetin results in increased expression of and affects the localization of HIF1A protein
fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
fisetin results in increased expression of HIF1A mRNA
CTD PMID:20153296 PMID:25428606 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
fisetin results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]
fisetin results in increased expression of HMOX1 mRNA; fisetin results in increased expression of HMOX1 protein
CTD PMID:16799064 PMID:30076913 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein] CTD PMID:28181380 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Il13 interleukin 13 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:12789233 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein] CTD PMID:18958421 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
fisetin results in decreased expression of IL4 protein
CTD PMID:12789233 PMID:16343431 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL5 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]
fisetin inhibits the reaction [Lead results in increased expression of IL6 protein]
CTD PMID:18958421 PMID:22931364 PMID:31539617 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; fisetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of JUN protein CTD PMID:31044527 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Lats2 large tumor suppressor 2 increases phosphorylation ISO fisetin results in increased phosphorylation of LATS2 protein CTD PMID:31044527 NCBI chr14:57,689,662...57,746,212
Ensembl chr14:57,689,662...57,758,388
Ensembl chr14:57,689,662...57,758,388
JBrowse link
G Lin7a lin-7 homolog A (C. elegans) multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of LIN7A mRNA] CTD PMID:30890323 NCBI chr10:107,271,549...107,425,146
Ensembl chr10:107,271,686...107,421,474
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 increases expression ISO fisetin results in increased expression of MAP3K20 protein CTD PMID:31044527 NCBI chr 2:72,285,637...72,442,610
Ensembl chr 2:72,285,637...72,442,610
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO fisetin results in increased phosphorylation of MAPK1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO fisetin results in increased phosphorylation of MAPK3 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP fisetin inhibits the reaction [Lead results in increased phosphorylation of MAPT protein] CTD PMID:31539617 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mme membrane metallo endopeptidase multiple interactions EXP fisetin inhibits the reaction [Lead results in decreased expression of MME protein] CTD PMID:31539617 NCBI chr 3:63,295,211...63,383,713
Ensembl chr 3:63,241,537...63,386,030
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
EXP
ISO
fisetin results in decreased expression of MMP2 mRNA; fisetin results in decreased expression of MMP2 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP2 protein]
HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]
CTD PMID:30076913 PMID:31606474 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO
EXP
fisetin inhibits the reaction [Silicon Dioxide results in increased expression of MMP9 mRNA]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP9 protein]
fisetin results in decreased expression of MMP9 mRNA; fisetin results in decreased expression of MMP9 protein
HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]
CTD PMID:22931364 PMID:30076913 PMID:31606474 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased activity of MPO protein] CTD PMID:25184746 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP fisetin inhibits the reaction [Lead results in increased expression of MYD88 protein] CTD PMID:31539617 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 multiple interactions ISO fisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein] CTD PMID:12789233 NCBI chr 2:168,476,410...168,601,657
Ensembl chr 2:168,476,410...168,601,657
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO
EXP
fisetin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]
CTD PMID:16799064 PMID:30076913 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO fisetin results in decreased expression of NFKB1 protein CTD PMID:30802432 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:25184746 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
fisetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
fisetin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD PMID:17177504 PMID:25184746 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA] CTD PMID:25184746 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:25184746 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO fisetin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nrgn neurogranin multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of NRGN mRNA] CTD PMID:30890323 NCBI chr 9:37,544,493...37,552,745
Ensembl chr 9:37,544,492...37,552,904
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases activity ISO fisetin results in decreased activity of PARP1 protein CTD PMID:17884996 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Prom1 prominin 1 decreases expression ISO fisetin results in decreased expression of PROM1 protein CTD PMID:30802432 NCBI chr 5:43,993,621...44,102,047
Ensembl chr 5:43,993,620...44,102,032
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]
fisetin inhibits the reaction [Lead affects the localization of RELA protein]
fisetin inhibits the reaction [Cisplatin affects the localization of and results in increased activity of RELA protein]
CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [fisetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 multiple interactions ISO [fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Snap25 synaptosomal-associated protein 25 multiple interactions EXP fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 NCBI chr 2:136,713,439...136,782,428
Ensembl chr 2:136,713,453...136,782,428
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 increases expression ISO fisetin results in increased expression of SREBF2 protein alternative form CTD PMID:23524313 NCBI chr15:82,147,269...82,205,379
Ensembl chr15:82,147,181...82,205,379
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]
fisetin results in decreased expression of STAT3 protein
CTD PMID:20153296 PMID:30802432 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Stx1a syntaxin 1A (brain) multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of STX1A mRNA] CTD PMID:30890323 NCBI chr 5:135,023,482...135,051,100
Ensembl chr 5:135,023,482...135,051,100
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP fisetin inhibits the reaction [Lead results in increased expression of TLR4 protein] CTD PMID:31539617 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]
fisetin inhibits the reaction [Lead results in increased expression of TNF protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
affects localization
increases expression
ISO [Cisplatin co-treated with fisetin] affects the localization of TP53 protein; [Cisplatin co-treated with fisetin] results in increased expression of TP53 protein; [Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of TP53 mRNA]; SB 203580 inhibits the reaction [[Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
fisetin affects the localization of TP53 protein
fisetin results in increased expression of TP53 protein
CTD PMID:21216935 PMID:22931364 PMID:25184746 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO fisetin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; fisetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO fisetin results in decreased expression of VIM protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
CTD PMID:30802432 PMID:31606474 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Yap1 yes-associated protein 1 multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:31044527 NCBI chr 9:7,931,999...8,004,638
Ensembl chr 9:7,931,999...8,004,596
JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase multiple interactions EXP herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions EXP herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions EXP herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr15:82,147,269...82,205,379
Ensembl chr15:82,147,181...82,205,379
JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Ins2 insulin II multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Syn1 synapsin I affects response to substance EXP SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004
JBrowse link
isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions
ISO homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
CTD PMID:24374571 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Il6 interleukin 6 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
isorhamnetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport
increases expression
ISO ABCB1 protein results in increased transport of 3-methylquercetin
3-methylquercetin results in increased expression of ABCB1 mRNA
CTD PMID:15969930 PMID:26238175 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO 3-methylquercetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:27151496 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] CTD PMID:17374653 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] CTD PMID:19794518 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions
EXP
ISO
3-methylquercetin results in decreased phosphorylation of AKT1 protein
3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]
CTD PMID:12826665 PMID:19222219 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO 3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein CTD PMID:22992727 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO 3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein CTD PMID:22992727 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity
ISO
EXP
3-methylquercetin results in decreased expression of CASP3 protein
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
3-methylquercetin results in increased activity of CASP3 protein
CTD PMID:12826665 PMID:19222219 PMID:22992727 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 decreases expression ISO 3-methylquercetin results in decreased expression of CASP9 protein CTD PMID:22992727 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein CTD PMID:19222219 PMID:25716194 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions EXP [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA CTD PMID:20579867 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein CTD PMID:22992727 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27151496 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 3-methylquercetin results in decreased expression of CYP1B1 mRNA CTD PMID:19794518 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding ISO 3-methylquercetin binds to ESR1 protein CTD PMID:14706564 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding ISO 3-methylquercetin binds to ESR2 protein CTD PMID:14706564 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein
CTD PMID:24211276 PMID:25716194 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:27151496 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein
CTD PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA
CTD PMID:20579867 PMID:23774260 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA
CTD PMID:20579867 PMID:23774260 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:19222219 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mir155 microRNA 155 multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] CTD PMID:20579867 NCBI chr16:84,714,140...84,714,204
Ensembl chr16:84,714,140...84,714,204
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:17374653 PMID:18436224 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects response to substance
multiple interactions
affects localization
increases activity
ISO
EXP
NFE2L2 protein affects the susceptibility to 3-methylquercetin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
3-methylquercetin affects the localization of NFE2L2 protein
[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide]
CTD PMID:24211276 PMID:27151496 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23774260 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA CTD PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] CTD PMID:16891912 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:24211276 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
3-methylquercetin binds to and results in increased activity of NR1I2 protein
3-methylquercetin results in increased activity of NR1I2 protein
CTD PMID:26238175 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] CTD PMID:16891912 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO 3-methylquercetin results in increased cleavage of PARP1 protein CTD PMID:22992727 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 decreases expression ISO 3-methylquercetin results in decreased expression of PECAM1 protein CTD PMID:22992727 NCBI chr11:106,654,213...106,715,281
Ensembl chr11:106,654,217...106,750,628
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO 3-methylquercetin results in increased expression of PON1 mRNA CTD PMID:20228421 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Pon2 paraoxonase 2 increases expression EXP 3-methylquercetin results in increased expression of PON2 mRNA CTD PMID:19865538 NCBI chr 6:5,264,620...5,298,345
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases activity ISO 3-methylquercetin results in increased activity of PPARD protein CTD PMID:22992727 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein
3-methylquercetin results in increased expression of PPARG protein
CTD PMID:22992727 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO 3-methylquercetin results in increased phosphorylation of PRKCD protein CTD PMID:24211276 NCBI chr14:30,595,353...30,626,414
Ensembl chr14:30,595,354...30,626,210
JBrowse link
G Ptges prostaglandin E synthase multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 2:30,889,471...30,931,020
Ensembl chr 2:30,889,471...30,929,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
EXP
ISO
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]
3-methylquercetin results in decreased activity of PTGS2 protein
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]
CTD PMID:15292928 PMID:21341175 PMID:24337631 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]
CTD PMID:27151496 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA CTD PMID:24211276 NCBI chr 4:132,492,804...132,510,456
Ensembl chr 4:132,492,032...132,510,501
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:27151496 NCBI chr18:76,241,090...76,311,748
Ensembl chr18:76,241,580...76,310,963
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 3-methylquercetin results in increased expression of TFF1 mRNA CTD PMID:14706564 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:20579867 PMID:23774260 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tyr tyrosinase increases expression EXP 3-methylquercetin results in increased expression of TYR protein CTD PMID:24853321 NCBI chr 7:87,424,771...87,493,512
Ensembl chr 7:87,424,771...87,493,512
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression EXP 3-methylquercetin results in increased expression of TYRP1 protein CTD PMID:24853321 NCBI chr 4:80,834,123...80,851,736
Ensembl chr 4:80,834,123...80,851,719
JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
kaempferol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of kaempferol
kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD PMID:15266218 PMID:15969930 PMID:20438634 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity
increases activity
multiple interactions
affects activity
ISO kaempferol results in decreased activity of ABCC1 protein
kaempferol results in increased activity of ABCC1 protein
kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
kaempferol affects the activity of ABCC1 protein
CTD PMID:11306701 PMID:15670588 PMID:15796199 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] CTD PMID:30497708 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta decreases expression EXP kaempferol results in decreased expression of ACTA2 protein CTD PMID:26683311 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Afp alpha fetoprotein affects binding
decreases expression
ISO
EXP
kaempferol binds to AFP protein
kaempferol results in decreased expression of AFP protein
CTD PMID:23013281 PMID:25349334 PMID:26683311 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ahr aryl-hydrocarbon receptor affects binding
multiple interactions
increases activity
ISO
EXP
kaempferol binds to AHR protein
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
kaempferol results in increased activity of AHR protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
CTD PMID:10359656 PMID:14644660 PMID:17012224 PMID:19034627 PMID:19794518 PMID:20450880 PMID:20846786 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions EXP kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr19:4,113,756...4,126,559
Ensembl chr19:4,114,446...4,125,858
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO
EXP
kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
kaempferol results in decreased phosphorylation of AKT1 protein
kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]
CTD PMID:18591783 PMID:19244381 PMID:20438634 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alox12 arachidonate 12-lipoxygenase decreases activity
multiple interactions
ISO kaempferol results in decreased activity of ALOX12 protein
kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
CTD PMID:17027136 NCBI chr11:70,241,457...70,255,380
Ensembl chr11:70,241,457...70,255,353
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Apoe apolipoprotein E multiple interactions EXP kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Ar androgen receptor multiple interactions ISO kaempferol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP
ISO
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
CTD PMID:17012224 PMID:20450880 PMID:20846786 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions
increases phosphorylation
ISO Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein] CTD PMID:19028473 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G B3galt5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 decreases expression ISO kaempferol results in decreased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr16:96,235,801...96,319,859
Ensembl chr16:96,235,801...96,319,859
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO
EXP
kaempferol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]
CTD PMID:19028473 PMID:22155320 PMID:29574133 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions
increases expression
ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein]; kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO kaempferol results in decreased expression of BCL2 protein CTD PMID:19028473 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP kaempferol results in increased expression of BMP2 mRNA; kaempferol results in increased expression of BMP2 protein CTD PMID:23989061 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression EXP kaempferol results in increased expression of BMP4 mRNA CTD PMID:23989061 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Calcr calcitonin receptor multiple interactions EXP kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:16434028 NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714
JBrowse link
G Casp1 caspase 1 multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein] CTD PMID:28711657 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
kaempferol results in increased cleavage of CASP3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
CTD PMID:16014620 PMID:18331776 PMID:19028473 PMID:19397994 PMID:20594614 PMID:22155320 PMID:29574133 PMID:29999212 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO kaempferol results in increased cleavage of CASP9 protein
kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD PMID:18331776 PMID:20594614 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO
EXP
kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]
CTD PMID:22155320 PMID:29574133 PMID:30372826 PMID:30497708 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cckar cholecystokinin A receptor multiple interactions ISO kaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein] CTD PMID:24630973 NCBI chr 5:53,698,485...53,707,704
Ensembl chr 5:53,697,776...53,707,705
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP
ISO
kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]
CTD PMID:16434028 PMID:20438634 PMID:31306686 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA CTD PMID:16797527 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions
ISO kaempferol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]
CTD PMID:23384675 NCBI chr 2:163,820,752...163,833,146
Ensembl chr 2:163,820,861...163,833,146
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO kaempferol results in decreased expression of CCNB1 mRNA; kaempferol results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd14 CD14 antigen multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein] CTD PMID:28711657 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd44 CD44 antigen multiple interactions EXP
ISO
kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]
kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]
CTD PMID:22005275 PMID:28711657 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:11322924 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO kaempferol results in increased expression of CDKN1A mRNA; kaempferol results in increased expression of CDKN1A protein CTD PMID:19397994 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C decreases expression ISO kaempferol results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator affects localization ISO kaempferol affects the localization of CFTR protein mutant form CTD PMID:15191910 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation EXP kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation EXP kaempferol results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase decreases phosphorylation
multiple interactions
ISO
EXP
kaempferol results in decreased phosphorylation of CHUK protein
kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]
CTD PMID:17184768 PMID:30769083 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression EXP kaempferol results in increased expression of COL10A1 mRNA CTD PMID:23989061 NCBI chr10:34,389,981...34,397,085
Ensembl chr10:34,389,981...34,397,085
JBrowse link
G Col2a1 collagen, type II, alpha 1 increases expression EXP kaempferol results in increased expression of COL2A1 mRNA CTD PMID:23989061 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO kaempferol inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression ISO kaempferol results in decreased expression of CRP mRNA; kaempferol results in decreased expression of CRP protein CTD PMID:17184768 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cs citrate synthase increases activity EXP kaempferol results in increased activity of CS protein CTD PMID:31306686 NCBI chr10:128,337,727...128,362,482
Ensembl chr10:128,337,734...128,362,479
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions
increases secretion
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]] CTD PMID:29999212 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of CXCL8 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of CXCL8 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 PMID:28711657 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
increases expression
ISO
EXP
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA]
kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
kaempferol results in decreased activity of CYP1A1 protein
kaempferol results in increased activity of CYP1A1 protein
kaempferol results in increased expression of CYP1A1 mRNA
CTD PMID:10359656 PMID:11454723 PMID:16271822 PMID:17012224 PMID:20846786 PMID:20930378 PMID:21053930 PMID:21256954 PMID:21329749 PMID:21482471 PMID:29584932 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO kaempferol results in increased expression of CYP1A2 mRNA
kaempferol results in decreased activity of CYP1A2 protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
kaempferol results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:18421621 PMID:19034627 PMID:20806393 PMID:21053930 PMID:21256954 PMID:29753067 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
decreases activity
ISO kaempferol results in decreased expression of CYP1B1 mRNA
kaempferol binds to and results in decreased activity of CYP1B1 protein; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
kaempferol results in decreased activity of CYP1B1 protein
CTD PMID:16271822 PMID:19794518 PMID:20846786 PMID:21053930 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
decreases activity
ISO kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
kaempferol results in decreased activity of CYP2C9 protein
CTD PMID:21053930 PMID:29753067 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
decreases activity
ISO kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
kaempferol results in decreased activity of CYP2C9 protein
CTD PMID:21053930 PMID:29753067 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein] CTD PMID:29574133 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Dhrs11 dehydrogenase/reductase (SDR family) member 11 decreases activity ISO kaempferol results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr11:84,820,721...84,829,067
Ensembl chr11:84,820,856...84,828,994
JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases activity
increases expression
multiple interactions
ISO kaempferol results in increased activity of DIO2 protein
kaempferol results in increased expression of DIO2 mRNA
kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
CTD PMID:17327447 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Duox1 dual oxidase 1 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA] CTD PMID:25177032 NCBI chr 2:122,313,010...122,347,972
Ensembl chr 2:122,315,672...122,347,972
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
affects binding
increases expression
increases activity
ISO
EXP
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 protein
kaempferol binds to ESR1 protein
kaempferol results in increased expression of ESR1 mRNA
CTD PMID:9751507 PMID:14579009 PMID:14706564 PMID:15182386 PMID:16118406 PMID:19913605 PMID:20846786 PMID:23384675 PMID:29162470 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
increases expression
affects binding
increases activity
ISO
EXP
Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; kaempferol binds to and results in increased activity of ESR2 protein; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein]
kaempferol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [kaempferol results in increased expression of ESR2 protein]
kaempferol binds to ESR2 protein
CTD PMID:9751507 PMID:12224631 PMID:14706564 PMID:15182386 PMID:16118406 PMID:18937077 PMID:19913605 PMID:27634370 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO kaempferol results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fn1 fibronectin 1 increases expression ISO kaempferol results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP
ISO
kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]
kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]
CTD PMID:15322261 PMID:16434028 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO kaempferol results in increased expression of GADD45B mRNA; kaempferol results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
kaempferol results in increased expression of GCLC mRNA
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]
CTD PMID:11864778 PMID:29574133 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO kaempferol results in increased expression of TP53I3 mRNA; kaempferol results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr12:4,810,475...4,817,155 JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP kaempferol inhibits the reaction [Ethanol results in increased activity of GPT protein]; kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein] CTD PMID:29574133 PMID:31785310 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr12:16,670,615...16,801,394
Ensembl chr12:16,670,615...16,800,886
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO kaempferol inhibits the reaction [Chlorpyrifos results in increased expression of GSK3B mRNA] CTD PMID:30497708 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions ISO [Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA CTD PMID:25111660 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO kaempferol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
increases expression
ISO
EXP
kaempferol results in increased phosphorylation of H2AX protein
kaempferol results in increased expression of H2AX protein
CTD PMID:19028473 PMID:24595819 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:14691983
G Hgf hepatocyte growth factor multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA
kaempferol results in increased expression of HMOX1 mRNA; kaempferol results in increased expression of HMOX1 protein
CTD PMID:14563492 PMID:16303981 PMID:19265714 PMID:25111660 PMID:29574133 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 PMID:18394220 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]
CTD PMID:15985724 PMID:18394220 PMID:18946510 PMID:19367675 PMID:28711657 PMID:30769083 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions ISO kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA; kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 PMID:16797527 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
CTD PMID:16434028 PMID:16797527 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30769083 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; kaempferol inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; kaempferol promotes the reaction [INS1 protein results in increased uptake of Glucose] CTD PMID:18262572 PMID:18591783 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein] CTD PMID:30769083 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Itgam integrin alpha M multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein] CTD PMID:28711657 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO kaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 PMID:20594614 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases mutagenesis ISO kaempferol results in increased mutagenesis of KMT2A gene CTD PMID:17468513 NCBI chr 9:44,803,355...44,881,352
Ensembl chr 9:44,803,355...44,881,296
JBrowse link
G Lamb2 laminin, beta 2 increases expression ISO kaempferol results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 9:108,479,847...108,490,530
Ensembl chr 9:108,479,736...108,490,530
JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein] CTD PMID:30769083 NCBI chr 4:31,963,492...32,023,470
Ensembl chr 4:31,964,097...32,023,467
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions
ISO
EXP
kaempferol results in increased activity of MAPK1 protein
kaempferol results in increased phosphorylation of MAPK1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]
CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions
ISO
EXP
kaempferol results in increased activity of MAPK3 protein
kaempferol results in increased phosphorylation of MAPK3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK8 protein CTD PMID:30499162 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK9 protein CTD PMID:30499162 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Met met proto-oncogene multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kaempferol results in decreased expression of MMP2 protein]; kaempferol results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 PMID:30499162 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mt2 metallothionein 2 increases expression ISO kaempferol results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA] CTD PMID:19367675 PMID:25177032 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Nanog Nanog homeobox increases expression EXP kaempferol results in increased expression of NANOG protein CTD PMID:26683311 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr 2:165,992,637...166,073,242
Ensembl chr 2:165,992,636...166,073,242
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
ISO
EXP
[kaempferol co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]
kaempferol inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA]
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]
kaempferol results in increased expression of NFE2L2 mRNA
CTD PMID:21256954 PMID:25111660 PMID:29574133 PMID:30497708 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation
multiple interactions
ISO kaempferol results in decreased phosphorylation of NFKBIA protein
kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD PMID:17184768 PMID:20438634 PMID:30769083 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression
multiple interactions
ISO
EXP
kaempferol results in decreased expression of NOS2 mRNA; kaempferol results in decreased expression of NOS2 protein
Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; tin protoporphyrin IX inhibits the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:11343698 PMID:12512693 PMID:14563492 PMID:15832817 PMID:16934226 PMID:17177504 PMID:17184768 PMID:18274639 PMID:18394220 PMID:19352036 PMID:30769083 PMID:31306686 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:25177032 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein CTD PMID:25111660 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity
ISO
EXP
[kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
kaempferol results in increased expression of NR1I2 mRNA
CTD PMID:19034627 PMID:25455453 PMID:26238175 PMID:29933105 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO kaempferol results in increased activity of NR1I3 protein CTD PMID:19034627 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Ocln occludin multiple interactions EXP kaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein] CTD PMID:31785310 NCBI chr13:100,496,504...100,552,718
Ensembl chr13:100,496,507...100,552,718
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
kaempferol results in increased cleavage of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein]
CTD PMID:16014620 PMID:22155320 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]] CTD PMID:29999212 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions
ISO kaempferol binds to PGR protein
kaempferol results in increased expression of PGR mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:14579009 PMID:23384675 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression
increases expression
ISO
EXP
kaempferol results in decreased expression of POU5F1 protein
kaempferol results in increased expression of POU5F1 protein
CTD PMID:22906706 PMID:26683311 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression
EXP
ISO
kaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG protein
CTD PMID:11343698 PMID:18262572 PMID:25765892 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO kaempferol results in increased expression of PPARGC1A mRNA CTD PMID:17327447 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO kaempferol results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr15:74,714,839...74,717,065
Ensembl chr15:74,714,839...74,717,069
JBrowse link
G Ptges prostaglandin E synthase multiple interactions EXP kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 2:30,889,471...30,931,020
Ensembl chr 2:30,889,471...30,929,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP
ISO
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]
kaempferol results in decreased expression of PTGS2 mRNA; kaempferol results in decreased expression of PTGS2 protein
CTD PMID:10783318 PMID:11343698 PMID:17184768 PMID:18394220 PMID:19352036 PMID:21341175 PMID:30769083 PMID:31306686 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD PMID:16434028 PMID:18274639 PMID:20438634 PMID:30769083 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 NCBI chr13:34,002,225...34,035,170
Ensembl chr13:34,002,363...34,037,147
JBrowse link
G Rpa3 replication protein A3 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA CTD PMID:16797527 NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
JBrowse link
G Runx2 runt related transcription factor 2 increases expression EXP kaempferol results in increased expression of RUNX2 mRNA CTD PMID:23989061 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 PMID:18394220 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Sfn stratifin increases expression ISO kaempferol results in increased expression of SFN mRNA; kaempferol results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 4:133,600,556...133,602,168
Ensembl chr 4:133,600,556...133,602,168
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [kaempferol results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
kaempferol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]
CTD PMID:17108059 PMID:25719685 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases activity
decreases expression
multiple interactions
ISO kaempferol results in decreased activity of SLC2A1 protein
kaempferol results in decreased expression of SLC2A1 mRNA
kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
CTD PMID:14642735 PMID:25719685 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc5a8 solute carrier family 5 (iodide transporter), member 8 multiple interactions EXP kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein] CTD PMID:31785310 NCBI chr10:88,885,992...88,929,515
Ensembl chr10:88,885,992...88,929,515
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 6:141,629,452...141,686,646
Ensembl chr 6:141,629,518...141,686,646
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases expression
ISO [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [Quercetin co-treated with kaempferol] results in increased expression of SOD1 protein
kaempferol results in increased expression of SOD1 protein
CTD PMID:25111660 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
affects response to substance
increases expression
EXP fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]
SOD2 protein affects the susceptibility to kaempferol
CTD PMID:23526725 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 increases expression EXP kaempferol results in increased expression of SOX9 mRNA CTD PMID:23989061 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form] CTD PMID:18274639 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA CTD PMID:16797527 NCBI chr10:128,270,498...128,292,853
Ensembl chr10:128,270,559...128,292,849
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO kaempferol results in increased expression of TFAM mRNA CTD PMID:17327447 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO kaempferol results in increased expression of TFF1 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]
CTD PMID:14706564 PMID:23384675 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] CTD PMID:10783318 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP kaempferol inhibits the reaction [Ethanol results in decreased expression of TJP1 protein] CTD PMID:31785310 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
EXP
ISO
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
kaempferol results in decreased activity of TNF protein
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD PMID:15322261 PMID:15985724 PMID:16434028 PMID:16934226 PMID:16987811 PMID:18394220 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30769083 PMID:31306686 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator multiple interactions EXP kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr 1:105,780,673...105,849,444
Ensembl chr 1:105,780,718...105,847,981
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein] CTD PMID:30769083 NCBI chr 2:101,678,420...101,701,668
Ensembl chr 2:101,678,429...101,701,669
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
affects response to substance
increases phosphorylation
increases expression
ISO Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]
TP53 protein affects the susceptibility to kaempferol
kaempferol results in increased expression of TP53 protein
CTD PMID:19028473 PMID:22155320 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trp63 transformation related protein 63 increases expression ISO kaempferol results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr16:25,683,763...25,892,088
Ensembl chr16:25,683,763...25,892,102
JBrowse link
G Trp73 transformation related protein 73 increases expression ISO kaempferol results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 4:154,056,249...154,139,875
Ensembl chr 4:154,056,253...154,140,208
Ensembl chr 4:154,056,253...154,140,208
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TSLP protein] CTD PMID:28711657 NCBI chr18:32,815,383...32,819,799
Ensembl chr18:32,815,383...32,819,797
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression EXP kaempferol results in decreased expression of TUBB3 protein CTD PMID:26683311 NCBI chr 8:123,411,553...123,422,015
Ensembl chr 8:123,411,424...123,422,015
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions ISO kaempferol inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) increases expression ISO kaempferol results in increased expression of UCP3 mRNA CTD PMID:17327447 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation
multiple interactions
ISO
EXP
UGT1A1 protein results in increased glucuronidation of kaempferol
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]
CTD PMID:14557274 PMID:29574133 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects glucuronidation
increases glucuronidation
ISO UGT1A3 mutant form affects the glucuronidation of kaempferol
UGT1A3 protein results in increased glucuronidation of kaempferol
CTD PMID:16738032 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Utrn utrophin increases expression ISO kaempferol results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr10:12,382,187...12,869,888
Ensembl chr10:12,382,188...12,869,365
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases activity ISO kaempferol results in increased activity of VDR protein CTD PMID:26366751 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
kaempferol 3-O-beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) affects activity ISO kaempferol-3-O-galactoside affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 4:138,831,857...138,835,189
Ensembl chr 4:138,831,857...138,835,186
JBrowse link
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22210036 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA] CTD PMID:22210036 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22210036 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22210036 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22210036 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22210036 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22210036 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22210036 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22210036 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
kuwanone G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases expression
EXP geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]
kuwanon G results in increased expression of ABCB1 mRNA; kuwanon G results in increased expression of ABCB1 protein
CTD PMID:29355567 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression
multiple interactions
EXP kuwanon G results in increased expression of ABCG1 mRNA; kuwanon G results in increased expression of ABCG1 protein
geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein]
CTD PMID:29355567 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Apoe apolipoprotein E multiple interactions EXP kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased uptake of Lipids] CTD PMID:29355567 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Grp gastrin releasing peptide multiple interactions EXP kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr18:65,872,751...65,886,599
Ensembl chr18:65,872,820...65,886,596
JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions EXP kuwanon G binds to and results in decreased activity of GRPR protein; kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr  X:163,513,904...163,549,736
Ensembl chr  X:163,513,904...163,549,677
JBrowse link
G Ifng interferon gamma multiple interactions EXP kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IFNG mRNA] CTD PMID:29355567 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL1B mRNA] CTD PMID:29355567 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 mRNA] CTD PMID:29355567 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of NFKBIA protein] CTD PMID:29355567 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP kuwanon G results in increased expression of NR1H3 protein CTD PMID:29355567 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein] CTD PMID:29355567 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF mRNA] CTD PMID:29355567 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
kuwanone H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grp gastrin releasing peptide multiple interactions ISO
EXP
kuwanon H inhibits the reaction [GRP protein binds to NMBR protein]
kuwanon H inhibits the reaction [GRP protein binds to GRPR protein]
CTD PMID:7646517 NCBI chr18:65,872,751...65,886,599
Ensembl chr18:65,872,820...65,886,596
JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions EXP kuwanon H binds to and results in decreased activity of GRPR protein; kuwanon H inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr  X:163,513,904...163,549,736
Ensembl chr  X:163,513,904...163,549,677
JBrowse link
G Nmbr neuromedin B receptor multiple interactions ISO kuwanon H inhibits the reaction [GRP protein binds to NMBR protein] CTD PMID:7646517 NCBI chr10:14,759,356...14,771,458
Ensembl chr10:14,705,591...14,770,850
JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO Luteolin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions EXP [Luteolin co-treated with Cisplatin] results in increased expression of ABCC2 protein; Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:23770416 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions EXP Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein] CTD PMID:23770416 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects activity ISO Luteolin affects the activity of ABCG2 protein CTD PMID:20403331 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Luteolin inhibits the reaction [cobaltous chloride results in increased activity of ACHE protein] CTD PMID:31362009 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions EXP Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:19747501 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO
EXP
Luteolin binds to and results in decreased activity of AHR protein
Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:14644660 PMID:20450880 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased phosphorylation of AKT1 protein
Luteolin results in increased phosphorylation of AKT1 protein
Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
[Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased expression of AKT1 protein
CTD PMID:18591783 PMID:18720166 PMID:19344998 PMID:20153296 PMID:20685402 PMID:21782929 PMID:22926442 PMID:25448439 PMID:27474067 PMID:27525270 PMID:32035215 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Asns asparagine synthetase multiple interactions ISO Luteolin inhibits the reaction [Tunicamycin results in increased expression of ASNS mRNA] CTD PMID:32407927 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein modified form] CTD PMID:32407927 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Luteolin results in increased expression of ATG5 protein
Luteolin inhibits the reaction [Methamphetamine results in increased expression of ATG5 protein]
CTD PMID:32035215 PMID:32268164 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BAX protein]
Luteolin results in increased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of BAX protein]
CTD PMID:21601631 PMID:27474067 PMID:27525270 PMID:32035215 PMID:32268164 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of BCL2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2 protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] CTD PMID:19557821 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Luteolin results in decreased expression of BCL2L1 protein
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2L1 protein]
CTD PMID:21601631 PMID:25448439 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
Luteolin results in increased expression of BECN1 protein
CTD PMID:32035215 PMID:32268164 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15334063 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased cleavage of CASP3 protein]; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Luteolin results in increased expression of and results in increased cleavage of CASP3 protein
Luteolin results in increased expression of CASP3 protein
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Luteolin results in increased activity of CASP3 protein
Luteolin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]
CTD PMID:16140950 PMID:18331776 PMID:19397994 PMID:21074525 PMID:21601631 PMID:23770416 PMID:24525192 PMID:27474067 PMID:27489195 PMID:27525270 PMID:31288002 PMID:32035215 PMID:32268164 PMID:32407927 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 increases activity ISO Luteolin results in increased activity of CASP7 protein CTD PMID:21074525 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]
CTD PMID:15334063 PMID:16140950 PMID:24525192 PMID:27525270 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
ISO Luteolin results in increased activity of CASP9 protein
Luteolin results in increased cleavage of CASP9 protein
CTD PMID:18331776 PMID:19397994 PMID:21601631 PMID:27474067 PMID:27489195 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase affects activity
decreases activity
multiple interactions
ISO
EXP
Luteolin affects the activity of CAT protein
Luteolin results in decreased activity of CAT protein
Fluorouracil promotes the reaction [Luteolin results in decreased activity of CAT protein]; Luteolin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Luteolin promotes the reaction [Fluorouracil results in decreased activity of CAT protein]
CTD PMID:18503759 PMID:31288002 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccn5 cellular communication network factor 5 decreases expression ISO Luteolin results in decreased expression of CCN5 mRNA CTD PMID:19397994 NCBI chr 2:163,820,752...163,833,146
Ensembl chr 2:163,820,861...163,833,146
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Luteolin results in decreased expression of CCNA2 protein CTD PMID:22926442 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Luteolin results in decreased expression of CCNB1 mRNA; Luteolin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 PMID:22926442 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP Fluorouracil promotes the reaction [Luteolin results in decreased expression of CCND1 protein]; Luteolin promotes the reaction [Fluorouracil results in decreased expression of CCND1 protein] CTD PMID:31288002 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) decreases expression ISO Luteolin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein] CTD PMID:27474067 PMID:32268164 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein] CTD PMID:27474067 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CDH5 mRNA] CTD PMID:32035215 NCBI chr 8:104,101,613...104,144,504
Ensembl chr 8:104,101,625...104,144,511
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Luteolin results in decreased expression of CDK1 protein CTD PMID:22926442 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression
decreases activity
ISO Luteolin results in decreased expression of CDK2 protein
Luteolin results in decreased activity of CDK2 protein
CTD PMID:11322924 PMID:22926442 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions
ISO
EXP
Luteolin results in increased expression of CDKN1A mRNA; Luteolin results in increased expression of CDKN1A protein
Fluorouracil promotes the reaction [Luteolin results in increased expression of CDKN1A protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of CDKN1A protein]
CTD PMID:11322924 PMID:11790449 PMID:19397994 PMID:22926442 PMID:31288002 PMID:32268164 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Luteolin results in increased expression of CDKN1B protein CTD PMID:11322924 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C decreases expression ISO Luteolin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of CHUK protein] CTD PMID:25448439 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) decreases expression
multiple interactions
ISO Luteolin results in decreased expression of CSF2 mRNA
Luteolin inhibits the reaction [Calcimycin results in increased expression of CSF2 mRNA]
CTD PMID:10718847 PMID:17950587 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO Luteolin results in decreased expression of CTNNB1 protein CTD PMID:32268164 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CXCL12 mRNA] CTD PMID:32035215 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of CXCL8 protein] CTD PMID:25448439 PMID:30133131 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA] CTD PMID:19426678 NCBI chr 5:92,321,331...92,328,079
Ensembl chr 5:92,321,347...92,328,079
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO
EXP
Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Dust analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of CYP1A1 mRNA]
Luteolin results in increased expression of CYP1A1 mRNA
Luteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
Luteolin results in decreased activity of CYP1A1 protein
CTD PMID:16263508 PMID:17090139 PMID:20403331 PMID:20930378 PMID:21482471 PMID:23994263 PMID:29584932 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Luteolin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
ISO Luteolin results in decreased activity of CYP1B1 protein
Luteolin results in increased expression of CYP1B1 mRNA
CTD PMID:21482471 PMID:23994263 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO Luteolin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Luteolin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO Luteolin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Luteolin inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:23770416 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions ISO Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]; SESN2 protein promotes the reaction [Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]] CTD PMID:32407927 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dhrs11 dehydrogenase/reductase (SDR family) member 11 decreases activity ISO Luteolin results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr11:84,820,721...84,829,067
Ensembl chr11:84,820,856...84,828,994
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO Luteolin inhibits the reaction [Tunicamycin results in increased expression of DNAJB9 mRNA] CTD PMID:32407927 NCBI chr12:44,205,897...44,210,068
Ensembl chr12:44,205,559...44,210,326
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 increases expression
multiple interactions
EXP Luteolin results in increased expression of DRAM1 protein
Fluorouracil promotes the reaction [Luteolin results in increased expression of DRAM1 protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of DRAM1 protein]
CTD PMID:31288002 NCBI chr10:88,322,801...88,364,359
Ensembl chr10:88,322,804...88,379,080
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of EGFR protein]; EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein] CTD PMID:10556937 PMID:12168845 PMID:15135307 PMID:22926442 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
affects response to substance
ISO Luteolin results in decreased expression of EGFR mRNA
EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of EGFR protein]; Luteolin affects the activity of and results in decreased phosphorylation of EGFR protein; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Luteolin results in decreased phosphorylation of and results in increased activity of EGFR protein
EGFR protein affects the susceptibility to Luteolin
CTD PMID:10556937 PMID:12168845 PMID:15135307 PMID:22926442 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 increases expression ISO Luteolin results in increased expression of EGR1 mRNA CTD PMID:19397994 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Luteolin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein] CTD PMID:32407927 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions ISO Luteolin inhibits the reaction [Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of ERN1 protein] CTD PMID:32407927 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
ISO Luteolin binds to ESR1 protein
Luteolin inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:14579009 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases activity
affects binding
ISO Luteolin results in increased activity of ESR2 protein
Luteolin binds to ESR2 protein
CTD PMID:12224631 PMID:16860978 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F11r F11 receptor multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of F11R mRNA] CTD PMID:32035215 NCBI chr 1:171,437,561...171,464,593
Ensembl chr 1:171,437,535...171,464,603
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Luteolin inhibits the reaction [Tunicamycin results in increased expression of FASN mRNA] CTD PMID:32407927 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO Luteolin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Luteolin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases activity
ISO Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]
Luteolin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA]
Luteolin results in decreased activity of FOS protein
CTD PMID:15322261 PMID:16343431 PMID:17950587 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosb FBJ osteosarcoma oncogene B decreases activity ISO Luteolin results in decreased activity of FOSB protein CTD PMID:16343431 NCBI chr 7:19,302,696...19,310,118
Ensembl chr 7:19,302,696...19,310,051
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO Luteolin results in increased expression of and results in increased phosphorylation of FOXO3 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of FOXO3 protein]; PD 0325901 promotes the reaction [Luteolin results in increased expression of FOXO3 protein] CTD PMID:32268164 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO Luteolin results in increased expression of GADD45B mRNA; Luteolin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Luteolin results in increased expression of GCLC mRNA; Luteolin results in increased expression of GCLC protein
[Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
CTD PMID:22864849 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Luteolin results in increased expression of GCLM mRNA; Luteolin results in increased expression of GCLM protein CTD PMID:22864849 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of GFAP protein] CTD PMID:19747501 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Luteolin results in increased expression of TP53I3 mRNA; Luteolin results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr12:4,810,475...4,817,155 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP [Luteolin co-treated with 4(G)-alpha-glucopyranosyl-rutin] inhibits the reaction [Doxorubicin results in decreased activity of GPX1 protein] CTD PMID:9242351 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Luteolin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
decreases activity
ISO Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Luteolin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Luteolin results in increased expression of and results in increased activity of HIF1A protein
Luteolin results in decreased activity of HIF1A protein
CTD PMID:19958256 PMID:20153296 PMID:25448439 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]
Luteolin results in increased expression of HMOX1 protein
Luteolin results in increased expression of HMOX1 mRNA; Luteolin results in increased expression of HMOX1 protein
[Luteolin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
CTD PMID:10975858 PMID:22864849 PMID:32268164 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO
EXP
Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]
Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:32407927 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15113938 PMID:15322261 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:19426678 NCBI chr 4:88,522,025...88,522,794
Ensembl chr 4:88,522,025...88,522,774
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
EXP
ISO
Luteolin results in increased expression of IFNG protein
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:12755373 PMID:18090225 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO
Luteolin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Luteolin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
CTD PMID:16934226 PMID:30016632 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA] CTD PMID:19426678 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Luteolin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:17950587 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein] CTD PMID:25450234 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of IL1B protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]
CTD PMID:18090225 PMID:18946510 PMID:19557821 PMID:20685402 PMID:24134915 PMID:25448439 PMID:25450234 PMID:30016632 PMID:31362009 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il27 interleukin 27 multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA] CTD PMID:19426678 NCBI chr 7:126,589,009...126,595,035
Ensembl chr 7:126,589,010...126,594,941
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Luteolin inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA] CTD PMID:17950587 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO
EXP
Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4]
Luteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
Luteolin results in decreased expression of IL4 protein
CTD PMID:12755373 PMID:16343431 PMID:16601352 PMID:17950587 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 decreases expression EXP Luteolin results in decreased expression of IL5 protein CTD PMID:12755373 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]
CTD PMID:11123379 PMID:18720166 PMID:19426678 PMID:24134915 PMID:25448439 PMID:25450234 PMID:30016632 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP Luteolin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]; Luteolin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Insr insulin receptor multiple interactions EXP Luteolin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:18591783 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP Luteolin inhibits the reaction [Lipopolysaccharides promotes the reaction [IRF3 protein binds to IRF3 protein]]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:19426678 NCBI chr 7:44,997,648...45,002,848
Ensembl chr 7:44,997,648...45,002,848
JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases phosphorylation
ISO Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of JUN protein
Luteolin results in decreased phosphorylation of JUN protein
CTD PMID:15322261 PMID:15334063 PMID:16343431 PMID:17950587 PMID:30133131 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene decreases activity ISO Luteolin results in decreased activity of JUNB protein CTD PMID:16343431 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Jund jun D proto-oncogene decreases activity ISO Luteolin results in decreased activity of JUND protein CTD PMID:16343431 NCBI chr 8:70,697,739...70,700,616
Ensembl chr 8:70,698,949...70,700,616
JBrowse link
G Maoa monoamine oxidase A decreases activity
multiple interactions
ISO
EXP
Luteolin results in decreased activity of MAOA protein
Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]
CTD PMID:23009399 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein; PD 0325901 inhibits the reaction [Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:32268164 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]
Luteolin results in decreased phosphorylation of MAPK1 protein
Luteolin results in increased activity of MAPK1 protein
CTD PMID:10718847 PMID:15322261 PMID:17950587 PMID:17982879 PMID:19344998 PMID:19557821 PMID:22864849 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk10 mitogen-activated protein kinase 10 increases phosphorylation ISO Luteolin results in increased phosphorylation of MAPK10 protein CTD PMID:21601631 NCBI chr 5:102,908,547...103,212,604
Ensembl chr 5:102,907,948...103,211,334
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]
Luteolin results in decreased phosphorylation of MAPK3 protein
Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Luteolin results in increased activity of MAPK3 protein
CTD PMID:10718847 PMID:17950587 PMID:17982879 PMID:19344998 PMID:19557821 PMID:20685402 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Luteolin results in increased phosphorylation of MAPK8 protein
CTD PMID:10718847 PMID:15334063 PMID:21601631 PMID:30133131 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Luteolin results in increased phosphorylation of MAPK9 protein
Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]
CTD PMID:21601631 PMID:30133131 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions ISO Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) decreases expression ISO Luteolin results in decreased expression of MMP1 mRNA; Luteolin results in decreased expression of MMP1 protein CTD PMID:21112745 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
decreases secretion
ISO
EXP
Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of MMP9 protein]; Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein]
Luteolin results in increased expression of MMP9 protein
Luteolin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]
Luteolin results in decreased secretion of MMP9 protein
CTD PMID:10556937 PMID:15135307 PMID:19747501 PMID:25448439 PMID:30133131 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 multiple interactions ISO Luteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] CTD PMID:26800359 NCBI chr 8:107,293,435...107,379,517
Ensembl chr 8:107,293,470...107,379,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases activity
ISO [Luteolin results in increased activity of NFE2L2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; Luteolin affects the localization of and results in increased activity of NFE2L2 protein
[Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein
CTD PMID:17982879 PMID:22864849 PMID:32407927 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]
CTD PMID:15334063 PMID:18090225 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]
Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:11123379 PMID:15322261 PMID:16934226 PMID:18090225 PMID:19557821 PMID:25448439 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] CTD PMID:15322261 NCBI chr 7:28,758,251...28,766,644
Ensembl chr 7:28,758,251...28,767,512
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 NCBI chr11:71,091,197...71,144,969
Ensembl chr11:71,092,236...71,144,704
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of NOS2 protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:16934226 PMID:18090225 PMID:19426678 PMID:25448439 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO [Luteolin co-treated with linarin] results in increased expression of NOS3 protein modified form CTD PMID:29052401 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Luteolin results in decreased expression of NR1D1 mRNA CTD PMID:19397994 NCBI chr11:98,767,932...98,775,377
Ensembl chr11:98,767,932...98,775,333
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein] CTD PMID:25450234 NCBI chr 5:122,707,518...122,729,739
Ensembl chr 5:122,707,544...122,729,738
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO
EXP
[Luteolin co-treated with Paclitaxel] results in decreased expression of PARP1 protein; PD 0325901 promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]
Luteolin inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form]
CTD PMID:12168845 PMID:24525192 PMID:32268164 PMID:32407927 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of PDGFB mRNA] CTD PMID:32035215 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pkm pyruvate kinase, muscle increases activity ISO Luteolin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375
JBrowse link
G Plk1 polo like kinase 1 decreases expression ISO Luteolin results in decreased expression of PLK1 protein CTD PMID:22926442 NCBI chr 7:122,159,435...122,169,884
Ensembl chr 7:122,159,439...122,169,873
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] CTD PMID:30133131 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO Luteolin results in decreased expression of PSCA mRNA CTD PMID:18331776 PMID:19397994 NCBI chr15:74,714,839...74,717,065
Ensembl chr15:74,714,839...74,717,069
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of PTGS2 protein]; Luteolin inhibits the reaction [Dust analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Dust results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 mRNA]
Luteolin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD PMID:16263508 PMID:19557821 PMID:23770416 PMID:25448439 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions
decreases phosphorylation
ISO EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:15135307 PMID:25448439 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein] CTD PMID:25450234 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of and affects the localization of RELA protein]; Luteolin inhibits the reaction [Glucose affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein]
Luteolin inhibits the reaction [Cisplatin results in increased expression of RELA protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]
CTD PMID:15113938 PMID:15334063 PMID:18090225 PMID:19557821 PMID:23770416 PMID:25448439 PMID:30133131 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15113938 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
ISO
EXP
[Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; SESN2 protein promotes the reaction [Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]]
Luteolin inhibits the reaction [Tunicamycin results in increased expression of SESN2 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of SESN2 protein]
Luteolin results in increased expression of SESN2 mRNA; Luteolin results in increased expression of SESN2 protein
CTD PMID:32407927 NCBI chr 4:132,492,804...132,510,456
Ensembl chr 4:132,492,032...132,510,501
JBrowse link
G Sfn stratifin increases expression ISO Luteolin results in increased expression of SFN mRNA; Luteolin results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 4:133,600,556...133,602,168
Ensembl chr 4:133,600,556...133,602,168
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate; [Luteolin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 decreases activity ISO Luteolin results in decreased activity of SLC22A6 protein CTD PMID:32159797 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 decreases activity ISO Luteolin results in decreased activity of SLC22A8 protein CTD PMID:32159797 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 multiple interactions ISO [Luteolin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP Luteolin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 multiple interactions ISO Luteolin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr 5:33,104,219...33,162,699
Ensembl chr 5:33,104,219...33,162,870
JBrowse link
G Sod1 superoxide dismutase 1, soluble affects activity
multiple interactions
ISO
EXP
Luteolin affects the activity of SOD1 protein
Luteolin inhibits the reaction [Carbon Tetrachloride results in increased activity of SOD1 protein]
CTD PMID:18503759 PMID:19747501 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Luteolin results in increased expression of SOD2 protein CTD PMID:32268164 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Luteolin inhibits the reaction [Tunicamycin results in increased expression of SREBF1 mRNA] CTD PMID:32407927 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of STAT3 protein]; Luteolin promotes the reaction [Paclitaxel results in decreased phosphorylation of STAT3 protein]; Paclitaxel promotes the reaction [Luteolin results in decreased phosphorylation of STAT3 protein] CTD PMID:24525192 PMID:25448439 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity ISO Luteolin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr10:121,546,455...121,586,794
Ensembl chr10:121,546,455...121,586,787
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of TNF protein]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]
Luteolin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Luteolin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]
CTD PMID:11123379 PMID:15113938 PMID:15322261 PMID:15334063 PMID:16934226 PMID:17950587 PMID:18720166 PMID:19426678 PMID:19557821 PMID:23770416 PMID:25448439 PMID:25450234 PMID:30016632 PMID:31362009 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] CTD PMID:15334063 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased ubiquitination of and results in increased degradation of and results in decreased expression of XIAP protein] CTD PMID:16140950 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Top1 topoisomerase (DNA) I multiple interactions ISO Luteolin binds to and results in decreased activity of TOP1 protein CTD PMID:12027807 NCBI chr 2:160,645,897...160,722,764
Ensembl chr 2:160,645,888...160,722,764
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
EXP
ISO
Fluorouracil promotes the reaction [Luteolin results in increased expression of TRP53 protein]; Luteolin inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of TRP53 protein]
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of TP53 protein]
CTD PMID:23770416 PMID:27525270 PMID:31288002 PMID:32035215 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trp63 transformation related protein 63 increases expression ISO Luteolin results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr16:25,683,763...25,892,088
Ensembl chr16:25,683,763...25,892,102
JBrowse link
G Trp73 transformation related protein 73 increases expression ISO Luteolin results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 4:154,056,249...154,139,875
Ensembl chr 4:154,056,253...154,140,208
Ensembl chr 4:154,056,253...154,140,208
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Luteolin results in decreased activity of TXNRD1 protein CTD PMID:31288002 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Tyr tyrosinase increases expression EXP Luteolin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 7:87,424,771...87,493,512
Ensembl chr 7:87,424,771...87,493,512
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions
increases expression
ISO Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]
Luteolin results in increased expression of UGT1A1 mRNA
CTD PMID:20403331 PMID:29584932 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects glucuronidation
increases glucuronidation
ISO UGT1A3 mutant form affects the glucuronidation of Luteolin
UGT1A3 protein results in increased glucuronidation of Luteolin
CTD PMID:16738032 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Vav3 vav 3 oncogene decreases expression ISO Luteolin results in decreased expression of VAV3 mRNA CTD PMID:19397994 NCBI chr 3:109,340,465...109,685,694
Ensembl chr 3:109,340,653...109,685,698
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15113938 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link