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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydroxyflavone
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Accession:CHEBI:38684 term browser browse the term
Definition:Any hydroxyflavone carrying four hydroxy substituents.
Synonyms:related_synonym: tetrahydroxyflavones
 alt_id: CHEBI:26924;   CHEBI:27117

show annotations for term's descendants           Sort by:
 
4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MTNR1A melatonin receptor 1A affects binding EXP chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr 4:186,532,769...186,555,567
Ensembl chr 4:186,533,655...186,555,567 		JBrowse link
G MTNR1B melatonin receptor 1B affects binding EXP chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr11:92,969,651...92,986,241
Ensembl chr11:92,969,651...92,985,066
Ensembl chr11:92,969,651...92,985,066 		JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions EXP chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
6-hydroxyluteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases chemical synthesis		 EXP [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CYP1A1 protein results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases chemical synthesis
multiple interactions		 EXP CYP1B1 protein results in increased chemical synthesis of 6-hydroxyluteolin
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MITF melanocyte inducing transcription factor increases expression EXP afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,464...69,968,336
Ensembl chr 3:69,739,464...69,968,336 		JBrowse link
G TYR tyrosinase multiple interactions
increases expression		 EXP afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA		 CTD PMID:27287415 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G TYRP1 tyrosinase related protein 1 increases expression EXP afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285 		JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868 PMID:21482471 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity EXP diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PKM pyruvate kinase M1/2 increases activity EXP diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO
EXP		 Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions ISO Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]		 CTD PMID:21477647 PMID:32061149 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]		 CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP7 caspase 7 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP9 caspase 9 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases response to substance
increases metabolic processing
decreases activity
increases expression		 EXP CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA		 CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases metabolic processing
increases expression
decreases activity		 EXP CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein		 CTD PMID:19601638 PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFP alpha fetoprotein affects binding ISO fisetin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases localization EXP fisetin results in increased localization of AIFM1 protein CTD PMID:28181380 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO
EXP		 fisetin results in increased phosphorylation of AKT1 protein
fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]		 CTD PMID:20153296 PMID:25428606 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128 		JBrowse link
G AR androgen receptor multiple interactions
decreases expression		 EXP fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; fisetin results in decreased stability of and results in decreased expression of AR protein
fisetin results in decreased expression of AR mRNA		 CTD PMID:18922931 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATF6 activating transcription factor 6 increases expression
multiple interactions		 EXP fisetin results in increased expression of ATF6 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein]		 CTD PMID:28181380 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070 		JBrowse link
G ATF6B activating transcription factor 6 beta multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein] CTD PMID:28181380 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP [Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein CTD PMID:21216935 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression		 ISO
EXP		 fisetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
fisetin results in increased expression of BAX protein
fisetin inhibits the reaction [Lead results in increased expression of BAX protein]
fisetin affects the expression of BAX protein
[fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; U 0126 inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein]		 CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 fisetin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
fisetin inhibits the reaction [Lead results in decreased expression of BCL2 protein]
fisetin results in decreased expression of BCL2 protein
[fisetin co-treated with Paclitaxel] results in increased expression of BCL2 mRNA		 CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31539617 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression		 EXP [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein] CTD PMID:31044527 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of BDNF protein] CTD PMID:30890323 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BECN1 beclin 1 multiple interactions ISO fisetin promotes the reaction [Lead results in increased expression of BECN1 protein] CTD PMID:31539617 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
affects expression
increases cleavage		 EXP [Cisplatin co-treated with fisetin] results in increased cleavage of BID protein
fisetin affects the expression of BID protein
fisetin results in increased cleavage of BID protein		 CTD PMID:21216935 PMID:28181380 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP [Cisplatin co-treated with fisetin] results in decreased expression of BIRC5 protein CTD PMID:21216935 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CAPN1 calpain 1 increases expression
multiple interactions		 EXP fisetin results in increased expression of CAPN1 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN1 protein]		 CTD PMID:28181380 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006 		JBrowse link
G CAPN2 calpain 2 multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN2 protein] CTD PMID:28181380 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) increases expression
multiple interactions		 EXP fisetin results in increased expression of CASP12 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP12 protein]		 CTD PMID:28181380 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases activity		 EXP
ISO		 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased activity of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP3 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP3 protein; [fisetin co-treated with Paclitaxel] results in increased expression of CASP3 mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Lead results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]		 CTD PMID:21216935 PMID:21964635 PMID:22931364 PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP4 caspase 4 multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP4 protein] CTD PMID:28181380 NCBI chr11:104,942,866...104,968,596
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP7 caspase 7 multiple interactions EXP [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein] CTD PMID:21216935 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases activity		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein; fisetin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21216935 PMID:21964635 PMID:28181380 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity		 EXP
ISO		 [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP9 protein; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin results in increased cleavage of and results in increased activity of CASP9 protein
fisetin results in increased activity of CASP9 protein
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]		 CTD PMID:21216935 PMID:25184746 PMID:28181380 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:25184746 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions
decreases expression		 EXP [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein] CTD PMID:31044527 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP fisetin results in decreased expression of CCNA2 protein CTD PMID:28181380 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions
decreases expression		 EXP [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein
fisetin results in decreased expression of CCNB1 protein		 CTD PMID:21216935 PMID:28181380 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CD40 CD40 molecule multiple interactions EXP fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863 		JBrowse link
G CD44 CD44 molecule (Indian blood group) decreases expression EXP fisetin results in decreased expression of CD44 protein CTD PMID:30802432 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CDC25C cell division cycle 25C decreases expression EXP fisetin results in decreased expression of CDC25C protein CTD PMID:28181380 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355 		JBrowse link
G CDH1 cadherin 1 increases expression
multiple interactions		 EXP fisetin results in increased expression of CDH1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of CDH1 protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541 		JBrowse link
G CDH2 cadherin 2 multiple interactions EXP fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:31606474 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP fisetin results in decreased expression of CDK1 protein CTD PMID:28181380 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP fisetin results in decreased expression of CDK2 protein CTD PMID:28181380 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP [Cisplatin co-treated with fisetin] results in increased expression of CDKN1A protein
fisetin results in increased expression of CDKN1A protein		 CTD PMID:21216935 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339 		JBrowse link
G CHEK1 checkpoint kinase 1 increases expression EXP fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 increases expression EXP fisetin results in increased expression of CHEK2 protein CTD PMID:28181380 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975 		JBrowse link
G CPLX2 complexin 2 multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 NCBI chr 5:175,796,533...175,884,021
Ensembl chr 5:175,796,310...175,884,021 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased phosphorylation of CREB1 protein] CTD PMID:31539617 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression
multiple interactions		 EXP fisetin results in decreased expression of CTNNB1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CTNNB1 protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CXCL8 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of CXCL8 protein]; fisetin inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CXCL8 mRNA] CTD PMID:17884996 PMID:18958421 PMID:22931364 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA] CTD PMID:25184746 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP fisetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO fisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA] CTD PMID:23524313 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein] CTD PMID:28181380 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DDN dendrin multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of DDN mRNA] CTD PMID:30890323 NCBI chr12:48,995,149...49,001,773
Ensembl chr12:48,995,149...48,999,375 		JBrowse link
G DIO2 iodothyronine deiodinase 2 increases activity EXP fisetin results in increased activity of DIO2 protein CTD PMID:17327447 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of DLG4 protein] CTD PMID:31539617 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841 		JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR protein modified form] CTD PMID:31606474 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein CTD PMID:28181380 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,627,464 		JBrowse link
G ENDOG endonuclease G increases localization EXP fisetin results in increased localization of ENDOG protein CTD PMID:28181380 NCBI chr 9:128,818,402...128,822,676
Ensembl chr 9:128,818,500...128,822,676 		JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP fisetin results in decreased phosphorylation of and results in increased degradation of ERBB2 protein CTD PMID:30431692 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 decreases expression EXP fisetin results in decreased expression of ERBB3 protein CTD PMID:30431692 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G EXOC8 exocyst complex component 8 multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of EXOC8 mRNA] CTD PMID:30890323 NCBI chr 1:231,332,753...231,337,852
Ensembl chr 1:231,332,753...231,337,852 		JBrowse link
G FASLG Fas ligand multiple interactions
increases expression		 EXP [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein
fisetin results in increased expression of FASLG protein		 CTD PMID:21216935 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP fisetin results in increased expression of and affects the localization of FOS protein CTD PMID:31044527 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of GDNF protein] CTD PMID:30890323 NCBI chr 5:37,812,677...37,840,044
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in increased expression of GFAP protein] CTD PMID:30890323 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GSK3B protein modified form] CTD PMID:31606474 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:25184746 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
increases activity		 ISO
EXP		 cobaltous chloride promotes the reaction [fisetin results in increased activity of HIF1A protein]; fisetin promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; fisetin results in increased expression of and affects the localization of HIF1A protein
fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
fisetin results in increased expression of HIF1A mRNA		 CTD PMID:20153296 PMID:25428606 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 fisetin results in increased expression of HMOX1 protein
fisetin results in increased expression of HMOX1 mRNA; fisetin results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:30076913 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein] CTD PMID:28181380 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343 		JBrowse link
G IL13 interleukin 13 multiple interactions EXP fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:12789233 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein] CTD PMID:18958421 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression		 EXP fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
fisetin results in decreased expression of IL4 protein		 CTD PMID:12789233 PMID:16343431 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions EXP fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL5 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]
fisetin inhibits the reaction [Lead results in increased expression of IL6 protein]		 CTD PMID:18958421 PMID:22931364 PMID:31539617 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP fisetin results in increased phosphorylation of and affects the localization of JUN protein CTD PMID:31044527 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047 		JBrowse link
G KLK3 kallikrein related peptidase 3 multiple interactions
decreases expression		 EXP fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]; fisetin results in decreased expression of and results in decreased secretion of KLK3 protein
fisetin results in decreased expression of KLK3 mRNA		 CTD PMID:18922931 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764 		JBrowse link
G LATS2 large tumor suppressor kinase 2 increases phosphorylation EXP fisetin results in increased phosphorylation of LATS2 protein CTD PMID:31044527 NCBI chr13:20,973,036...21,061,586
Ensembl chr13:20,973,036...21,061,586 		JBrowse link
G LIN7A lin-7 homolog A, crumbs cell polarity complex component multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of LIN7A mRNA] CTD PMID:30890323 NCBI chr12:80,792,520...80,937,934
Ensembl chr12:80,792,520...80,937,925 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 increases expression EXP fisetin results in increased expression of MAP3K20 protein CTD PMID:31044527 NCBI chr 2:173,075,435...173,268,015
Ensembl chr 2:173,075,435...173,268,015 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 fisetin results in increased phosphorylation of MAPK1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]		 CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 fisetin results in increased phosphorylation of MAPK3 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO fisetin inhibits the reaction [Lead results in increased phosphorylation of MAPT protein] CTD PMID:31539617 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334 		JBrowse link
G MME membrane metalloendopeptidase multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of MME protein] CTD PMID:31539617 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO
EXP		 HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP2 protein]
fisetin results in decreased expression of MMP2 mRNA; fisetin results in decreased expression of MMP2 protein		 CTD PMID:30076913 PMID:31606474 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP
ISO		 fisetin inhibits the reaction [Silicon Dioxide results in increased expression of MMP9 mRNA]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP9 protein]
fisetin results in decreased expression of MMP9 mRNA; fisetin results in decreased expression of MMP9 protein
HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]		 CTD PMID:22931364 PMID:30076913 PMID:31606474 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased activity of MPO protein] CTD PMID:25184746 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of MYD88 protein] CTD PMID:31539617 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022 		JBrowse link
G NFATC2 nuclear factor of activated T cells 2 multiple interactions EXP fisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein] CTD PMID:12789233 NCBI chr20:51,386,963...51,562,857
Ensembl chr20:51,386,957...51,562,831 		JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions		 EXP
ISO		 fisetin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:30076913 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression EXP fisetin results in decreased expression of NFKB1 protein CTD PMID:30802432 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:25184746 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO fisetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
fisetin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]		 CTD PMID:17177504 PMID:25184746 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA] CTD PMID:25184746 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO fisetin inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:25184746 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases expression EXP fisetin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485 		JBrowse link
G NRGN neurogranin multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of NRGN mRNA] CTD PMID:30890323 NCBI chr11:124,739,942...124,747,210
Ensembl chr11:124,739,942...124,747,210 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 decreases activity EXP fisetin results in decreased activity of PARP1 protein CTD PMID:17884996 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PROM1 prominin 1 decreases expression EXP fisetin results in decreased expression of PROM1 protein CTD PMID:30802432 NCBI chr 4:15,968,226...16,084,059
Ensembl chr 4:15,963,076...16,084,378 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]
fisetin inhibits the reaction [Lead affects the localization of RELA protein]
fisetin inhibits the reaction [Cisplatin affects the localization of and results in increased activity of RELA protein]		 CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [fisetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 multiple interactions EXP [fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SNAP25 synaptosome associated protein 25 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 NCBI chr20:10,218,830...10,307,420
Ensembl chr20:10,218,830...10,307,418 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 increases expression EXP fisetin results in increased expression of SREBF2 protein alternative form CTD PMID:23524313 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 EXP fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]
fisetin results in decreased expression of STAT3 protein		 CTD PMID:20153296 PMID:30802432 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482 		JBrowse link
G STX1A syntaxin 1A multiple interactions ISO fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of STX1A mRNA] CTD PMID:30890323 NCBI chr 7:73,699,210...73,719,673
Ensembl chr 7:73,699,206...73,719,672 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of TLR4 protein] CTD PMID:31539617 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO		 fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]
fisetin inhibits the reaction [Lead results in increased expression of TNF protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions
affects localization
increases expression		 EXP
ISO		 [Cisplatin co-treated with fisetin] affects the localization of TP53 protein; [Cisplatin co-treated with fisetin] results in increased expression of TP53 protein; [Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of TP53 mRNA]; SB 203580 inhibits the reaction [[Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
fisetin affects the localization of TP53 protein
fisetin results in increased expression of TP53 protein		 CTD PMID:21216935 PMID:22931364 PMID:25184746 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,938...233,773,299 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP fisetin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; fisetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIM vimentin decreases expression
multiple interactions		 EXP fisetin results in decreased expression of VIM protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator multiple interactions EXP fisetin results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:31044527 NCBI chr11:102,109,957...102,233,424
Ensembl chr11:102,110,447...102,233,424 		JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FASN fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307 		JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G INS insulin multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions
decreases activity		 EXP [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin CTD PMID:32259555 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SYN1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857 		JBrowse link
isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]		 CTD PMID:24374571 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
isorhamnetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport
increases expression		 EXP ABCB1 protein results in increased transport of 3-methylquercetin
3-methylquercetin results in increased expression of ABCB1 mRNA		 CTD PMID:15969930 PMID:26238175 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP 3-methylquercetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:27151496 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AGT angiotensinogen multiple interactions ISO 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] CTD PMID:17374653 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] CTD PMID:19794518 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO 3-methylquercetin results in decreased phosphorylation of AKT1 protein
3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]		 CTD PMID:12826665 PMID:19222219 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP 3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein CTD PMID:22992727 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP 3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein CTD PMID:22992727 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 decreases expression
multiple interactions
increases activity		 EXP
ISO		 3-methylquercetin results in decreased expression of CASP3 protein
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
3-methylquercetin results in increased activity of CASP3 protein		 CTD PMID:12826665 PMID:19222219 PMID:22992727 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP9 caspase 9 decreases expression EXP 3-methylquercetin results in decreased expression of CASP9 protein CTD PMID:22992727 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein CTD PMID:19222219 PMID:25716194 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA CTD PMID:20579867 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP 3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein CTD PMID:22992727 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27151496 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP 3-methylquercetin results in decreased expression of CYP1B1 mRNA CTD PMID:19794518 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP 3-methylquercetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G ESR1 estrogen receptor 1 affects binding EXP 3-methylquercetin binds to ESR1 protein CTD PMID:14706564 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 affects binding EXP 3-methylquercetin binds to ESR2 protein CTD PMID:14706564 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein		 CTD PMID:24211276 PMID:25716194 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:27151496 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein		 CTD PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA		 CTD PMID:20579867 PMID:23774260 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA		 CTD PMID:20579867 PMID:23774260 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:19222219 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MIR155 microRNA 155 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] CTD PMID:20579867 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:17374653 PMID:18436224 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376 		JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects response to substance
multiple interactions
affects localization
increases activity		 EXP
ISO		 NFE2L2 protein affects the susceptibility to 3-methylquercetin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
3-methylquercetin affects the localization of NFE2L2 protein
[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide]		 CTD PMID:24211276 PMID:27151496 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23774260 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA CTD PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] CTD PMID:16891912 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:24211276 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity		 EXP
ISO		 3-methylquercetin binds to and results in increased activity of NR1I2 protein
3-methylquercetin results in increased activity of NR1I2 protein		 CTD PMID:26238175 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] CTD PMID:16891912 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP 3-methylquercetin results in increased cleavage of PARP1 protein CTD PMID:22992727 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 decreases expression EXP 3-methylquercetin results in decreased expression of PECAM1 protein CTD PMID:22992727 NCBI chr17:64,319,415...64,413,844
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PON1 paraoxonase 1 increases expression EXP 3-methylquercetin results in increased expression of PON1 mRNA CTD PMID:20228421 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PON2 paraoxonase 2 increases expression ISO 3-methylquercetin results in increased expression of PON2 mRNA CTD PMID:19865538 NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases activity EXP 3-methylquercetin results in increased activity of PPARD protein CTD PMID:22992727 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein
3-methylquercetin results in increased expression of PPARG protein		 CTD PMID:22992727 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKCD protein kinase C delta increases phosphorylation EXP 3-methylquercetin results in increased phosphorylation of PRKCD protein CTD PMID:24211276 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PTGES prostaglandin E synthase multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity		 ISO
EXP		 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]
3-methylquercetin results in decreased activity of PTGS2 protein
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]		 CTD PMID:15292928 PMID:21341175 PMID:24337631 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]		 CTD PMID:27151496 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SESN2 sestrin 2 multiple interactions EXP [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA CTD PMID:24211276 NCBI chr 1:28,259,452...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions EXP 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:27151496 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions EXP 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169 		JBrowse link
G TFF1 trefoil factor 1 increases expression EXP 3-methylquercetin results in increased expression of TFF1 mRNA CTD PMID:14706564 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:20579867 PMID:23774260 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TYR tyrosinase increases expression ISO 3-methylquercetin results in increased expression of TYR protein CTD PMID:24853321 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G TYRP1 tyrosinase related protein 1 increases expression ISO 3-methylquercetin results in increased expression of TYRP1 protein CTD PMID:24853321 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285 		JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC2A1 solute carrier family 2 member 1 decreases expression EXP kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
kaempferol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport
multiple interactions		 EXP ABCB1 protein results in increased transport of kaempferol
kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]		 CTD PMID:15266218 PMID:15969930 PMID:20438634 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity
increases activity
multiple interactions
affects activity		 EXP kaempferol results in decreased activity of ABCC1 protein
kaempferol results in increased activity of ABCC1 protein
kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
kaempferol affects the activity of ABCC1 protein		 CTD PMID:11306701 PMID:15670588 PMID:15796199 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074 		JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] CTD PMID:30497708 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression ISO kaempferol results in decreased expression of ACTA2 protein CTD PMID:26683311 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AFP alpha fetoprotein affects binding
decreases expression		 ISO kaempferol binds to AFP protein
kaempferol results in decreased expression of AFP protein		 CTD PMID:23013281 PMID:25349334 PMID:26683311 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AHR aryl hydrocarbon receptor affects binding
multiple interactions
increases activity		 EXP
ISO		 kaempferol binds to AHR protein
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
kaempferol results in increased activity of AHR protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]		 CTD PMID:10359656 PMID:14644660 PMID:17012224 PMID:19034627 PMID:19794518 PMID:20450880 PMID:20846786 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AIP aryl hydrocarbon receptor interacting protein multiple interactions ISO kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr11:67,468,179...67,491,103
Ensembl chr11:67,483,026...67,491,103 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 EXP
ISO		 kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
kaempferol results in decreased phosphorylation of AKT1 protein
kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]		 CTD PMID:18591783 PMID:19244381 PMID:20438634 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type decreases activity
multiple interactions		 EXP kaempferol results in decreased activity of ALOX12 protein
kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]		 CTD PMID:17027136 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G APOE apolipoprotein E multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128 		JBrowse link
G AR androgen receptor multiple interactions EXP kaempferol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions ISO
EXP		 kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]		 CTD PMID:17012224 PMID:20450880 PMID:20846786 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases phosphorylation		 EXP Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein] CTD PMID:19028473 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102 		JBrowse link
G B3GALT5 beta-1,3-galactosyltransferase 5 decreases expression EXP kaempferol results in decreased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr21:39,612,940...39,673,137
Ensembl chr21:39,556,442...39,673,137 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 kaempferol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]		 CTD PMID:19028473 PMID:22155320 PMID:29574133 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions
increases expression		 EXP Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein]; kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP kaempferol results in decreased expression of BCL2 protein CTD PMID:19028473 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BMP2 bone morphogenetic protein 2 increases expression ISO kaempferol results in increased expression of BMP2 mRNA; kaempferol results in increased expression of BMP2 protein CTD PMID:23989061 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP4 bone morphogenetic protein 4 increases expression ISO kaempferol results in increased expression of BMP4 mRNA CTD PMID:23989061 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G CALCR calcitonin receptor multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:16434028 NCBI chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730 		JBrowse link
G CASP1 caspase 1 multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein] CTD PMID:28711657 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage		 ISO
EXP		 kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
kaempferol results in increased cleavage of CASP3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]		 CTD PMID:16014620 PMID:18331776 PMID:19028473 PMID:19397994 PMID:20594614 PMID:22155320 PMID:29574133 PMID:29999212 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions		 EXP kaempferol results in increased cleavage of CASP9 protein
kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]		 CTD PMID:18331776 PMID:20594614 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]		 CTD PMID:22155320 PMID:29574133 PMID:30372826 PMID:30497708 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCKAR cholecystokinin A receptor multiple interactions ISO kaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein] CTD PMID:24630973 NCBI chr 4:26,481,396...26,490,484
Ensembl chr 4:26,481,396...26,490,484 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]		 CTD PMID:16434028 PMID:20438634 PMID:31306686 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA CTD PMID:16797527 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCN5 cellular communication network factor 5 increases expression
multiple interactions		 EXP kaempferol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr20:44,714,204...44,728,041
Ensembl chr20:44,714,844...44,728,509 		JBrowse link
G CCNB1 cyclin B1 decreases expression EXP kaempferol results in decreased expression of CCNB1 mRNA; kaempferol results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 multiple interactions EXP kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD14 CD14 molecule multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein] CTD PMID:28711657 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701 		JBrowse link
G CD44 CD44 molecule (Indian blood group) multiple interactions ISO
EXP		 kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]
kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]		 CTD PMID:22005275 PMID:28711657 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:11322924 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP kaempferol results in increased expression of CDKN1A mRNA; kaempferol results in increased expression of CDKN1A protein CTD PMID:19397994 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C decreases expression EXP kaempferol results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634 		JBrowse link
G CFTR CF transmembrane conductance regulator affects localization EXP kaempferol affects the localization of CFTR protein mutant form CTD PMID:15191910 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G CHEK1 checkpoint kinase 1 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation
multiple interactions		 EXP
ISO		 kaempferol results in decreased phosphorylation of CHUK protein
kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]		 CTD PMID:17184768 PMID:30769083 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression ISO kaempferol results in increased expression of COL10A1 mRNA CTD PMID:23989061 NCBI chr 6:116,118,909...116,219,937
Ensembl chr 6:116,118,909...116,158,747 		JBrowse link
G COL2A1 collagen type II alpha 1 chain increases expression ISO kaempferol results in increased expression of COL2A1 mRNA CTD PMID:23989061 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO kaempferol inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CRP C-reactive protein decreases expression EXP kaempferol results in decreased expression of CRP mRNA; kaempferol results in decreased expression of CRP protein CTD PMID:17184768 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CS citrate synthase increases activity ISO kaempferol results in increased activity of CS protein CTD PMID:31306686 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions
increases secretion		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]] CTD PMID:29999212 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of CXCL8 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of CXCL8 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 PMID:28711657 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions
affects localization		 EXP Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
increases activity
increases expression		 EXP
ISO		 [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA]
kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
kaempferol results in decreased activity of CYP1A1 protein
kaempferol results in increased activity of CYP1A1 protein
kaempferol results in increased expression of CYP1A1 mRNA		 CTD PMID:10359656 PMID:11454723 PMID:16271822 PMID:17012224 PMID:20846786 PMID:20930378 PMID:21053930 PMID:21256954 PMID:21329749 PMID:21482471 PMID:29584932 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
decreases activity
multiple interactions		 EXP
ISO		 kaempferol results in increased expression of CYP1A2 mRNA
kaempferol results in decreased activity of CYP1A2 protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
kaempferol results in increased expression of and results in increased activity of CYP1A2 protein		 CTD PMID:18421621 PMID:19034627 PMID:20806393 PMID:21053930 PMID:21256954 PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression
multiple interactions
decreases activity		 EXP kaempferol results in decreased expression of CYP1B1 mRNA
kaempferol binds to and results in decreased activity of CYP1B1 protein; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
kaempferol results in decreased activity of CYP1B1 protein		 CTD PMID:16271822 PMID:19794518 PMID:20846786 PMID:21053930 PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
decreases activity		 EXP kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
kaempferol results in decreased activity of CYP2C9 protein		 CTD PMID:21053930 PMID:29753067 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein] CTD PMID:29574133 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression
decreases activity
multiple interactions		 EXP kaempferol results in increased expression of CYP3A4 mRNA
kaempferol results in decreased activity of CYP3A4 protein
[kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone]		 CTD PMID:15266218 PMID:16442130 PMID:21053930 PMID:25455453 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DHRS11 dehydrogenase/reductase 11 decreases activity EXP kaempferol results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr17:36,591,846...36,600,804
Ensembl chr17:36,591,879...36,600,804 		JBrowse link
G DIO2 iodothyronine deiodinase 2 increases activity
increases expression
multiple interactions		 EXP kaempferol results in increased activity of DIO2 protein
kaempferol results in increased expression of DIO2 mRNA
kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]		 CTD PMID:17327447 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757 		JBrowse link
G DUOX1 dual oxidase 1 multiple interactions EXP kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA] CTD PMID:25177032 NCBI chr15:45,129,994...45,165,578
Ensembl chr15:45,129,933...45,165,576 		JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
affects binding
increases expression
increases activity		 EXP
ISO		 ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 protein
kaempferol binds to ESR1 protein
kaempferol results in increased expression of ESR1 mRNA		 CTD PMID:9751507 PMID:14579009 PMID:14706564 PMID:15182386 PMID:16118406 PMID:19913605 PMID:20846786 PMID:23384675 PMID:29162470 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases expression
affects binding
increases activity		 EXP
ISO		 Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; kaempferol binds to and results in increased activity of ESR2 protein; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein]
kaempferol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [kaempferol results in increased expression of ESR2 protein]
kaempferol binds to ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:14706564 PMID:15182386 PMID:16118406 PMID:18937077 PMID:19913605 PMID:27634370 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression EXP kaempferol results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FN1 fibronectin 1 increases expression EXP kaempferol results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]
kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]		 CTD PMID:15322261 PMID:16434028 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta increases expression EXP kaempferol results in increased expression of GADD45B mRNA; kaempferol results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions		 EXP
ISO		 kaempferol results in increased expression of GCLC mRNA
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]		 CTD PMID:11864778 PMID:29574133 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in increased activity of GPT protein]; kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein] CTD PMID:29574133 PMID:31785310 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 EXP fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr 2:11,481,675...11,642,788
Ensembl chr 2:11,482,341...11,642,788 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO kaempferol inhibits the reaction [Chlorpyrifos results in increased expression of GSK3B mRNA] CTD PMID:30497708 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression EXP kaempferol results in increased expression of GSTA1 mRNA CTD PMID:21256954 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions EXP [Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA CTD PMID:25111660 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP kaempferol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G H2AX H2A.X variant histone increases phosphorylation
increases expression		 EXP
ISO		 kaempferol results in increased phosphorylation of H2AX protein
kaempferol results in increased expression of H2AX protein		 CTD PMID:19028473 PMID:24595819 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467 		JBrowse link
G HBB hemoglobin subunit beta multiple interactions EXP kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:14691983 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395 		JBrowse link
G HCAR3 hydroxycarboxylic acid receptor 3 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of HCAR2 protein] CTD PMID:31785310 NCBI chr12:122,714,756...122,716,811
Ensembl chr12:122,714,756...122,716,811 		JBrowse link
G HGF hepatocyte growth factor multiple interactions EXP kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA
kaempferol results in increased expression of HMOX1 mRNA; kaempferol results in increased expression of HMOX1 protein		 CTD PMID:14563492 PMID:16303981 PMID:19265714 PMID:25111660 PMID:29574133 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 PMID:18394220 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions EXP kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP		 kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]		 CTD PMID:15985724 PMID:18394220 PMID:18946510 PMID:19367675 PMID:28711657 PMID:30769083 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL32 interleukin 32 multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CXCL8 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of CXCL8 protein]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein] CTD PMID:28711657 NCBI chr16:3,065,403...3,069,530
Ensembl chr16:3,065,297...3,082,192 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions EXP [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA; kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 PMID:16797527 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]		 CTD PMID:16434028 PMID:16797527 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30769083 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions EXP kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein] CTD PMID:30769083 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein] CTD PMID:28711657 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP kaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 PMID:20594614 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047 		JBrowse link
G KMT2A lysine methyltransferase 2A increases mutagenesis EXP kaempferol results in increased mutagenesis of KMT2A gene CTD PMID:17468513 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,490...118,526,832 		JBrowse link
G LAMB2 laminin subunit beta 2 increases expression EXP kaempferol results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 3:49,121,114...49,133,066
Ensembl chr 3:49,121,114...49,133,118 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 multiple interactions EXP kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein] CTD PMID:30769083 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,072 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions		 ISO
EXP		 kaempferol results in increased activity of MAPK1 protein
kaempferol results in increased phosphorylation of MAPK1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions		 ISO
EXP		 kaempferol results in increased activity of MAPK3 protein
kaempferol results in increased phosphorylation of MAPK3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP kaempferol results in increased phosphorylation of MAPK8 protein CTD PMID:30499162 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP kaempferol results in increased phosphorylation of MAPK9 protein CTD PMID:30499162 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kaempferol results in decreased expression of MMP2 protein]; kaempferol results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 PMID:30499162 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MT2A metallothionein 2A increases expression EXP kaempferol results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA] CTD PMID:19367675 PMID:25177032 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NANOG Nanog homeobox increases expression ISO kaempferol results in increased expression of NANOG protein CTD PMID:26683311 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 multiple interactions EXP kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877 		JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases expression		 EXP
ISO		 [kaempferol co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]
kaempferol inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA]
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]
kaempferol results in increased expression of NFE2L2 mRNA		 CTD PMID:21256954 PMID:25111660 PMID:29574133 PMID:30497708 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 EXP kaempferol results in decreased phosphorylation of NFKBIA protein
kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]		 CTD PMID:17184768 PMID:20438634 PMID:30769083 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions		 EXP
ISO		 kaempferol results in decreased expression of NOS2 mRNA; kaempferol results in decreased expression of NOS2 protein
Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; tin protoporphyrin IX inhibits the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]		 CTD PMID:11343698 PMID:12512693 PMID:14563492 PMID:15832817 PMID:16934226 PMID:17177504 PMID:17184768 PMID:18274639 PMID:18394220 PMID:19352036 PMID:30769083 PMID:31306686 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions EXP kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:25177032 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein CTD PMID:25111660 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
kaempferol results in increased expression of NR1I2 mRNA		 CTD PMID:19034627 PMID:25455453 PMID:26238175 PMID:29933105 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP kaempferol results in increased activity of NR1I3 protein CTD PMID:19034627 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302 		JBrowse link
G OCLN occludin multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein] CTD PMID:31785310 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO
EXP		 kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
kaempferol results in increased cleavage of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein]		 CTD PMID:16014620 PMID:22155320 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]] CTD PMID:29999212 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PGR progesterone receptor affects binding
increases expression
multiple interactions		 EXP kaempferol binds to PGR protein
kaempferol results in increased expression of PGR mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]		 CTD PMID:14579009 PMID:23384675 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression
increases expression		 EXP
ISO		 kaempferol results in decreased expression of POU5F1 protein
kaempferol results in increased expression of POU5F1 protein		 CTD PMID:22906706 PMID:26683311 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO
EXP		 kaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG protein		 CTD PMID:11343698 PMID:18262572 PMID:25765892 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP kaempferol results in increased expression of PPARGC1A mRNA CTD PMID:17327447 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PSCA prostate stem cell antigen decreases expression EXP kaempferol results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 8:142,670,297...142,682,725
Ensembl chr 8:142,670,308...142,682,725 		JBrowse link
G PTGES prostaglandin E synthase multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO
EXP		 kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]
kaempferol results in decreased expression of PTGS2 mRNA; kaempferol results in decreased expression of PTGS2 protein		 CTD PMID:10783318 PMID:11343698 PMID:17184768 PMID:18394220 PMID:19352036 PMID:21341175 PMID:30769083 PMID:31306686 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]		 CTD PMID:16434028 PMID:18274639 PMID:20438634 PMID:30769083 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,991...3,115,187
Ensembl chr 6:3,063,991...3,115,187 		JBrowse link
G RPA3 replication protein A3 multiple interactions EXP [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA CTD PMID:16797527 NCBI chr 7:7,636,518...7,718,607
Ensembl chr 7:7,636,518...7,718,607 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO kaempferol results in increased expression of RUNX2 mRNA CTD PMID:23989061 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SELE selectin E multiple interactions EXP kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 PMID:18394220 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SFN stratifin increases expression EXP kaempferol results in increased expression of SFN mRNA; kaempferol results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO
EXP		 [kaempferol results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
kaempferol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]		 CTD PMID:17108059 PMID:25719685 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases activity
decreases expression
multiple interactions		 EXP kaempferol results in decreased activity of SLC2A1 protein
kaempferol results in decreased expression of SLC2A1 mRNA
kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]		 CTD PMID:14642735 PMID:25719685 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC5A8 solute carrier family 5 member 8 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein] CTD PMID:31785310 NCBI chr12:101,155,493...101,210,238
Ensembl chr12:101,155,493...101,210,238 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions
decreases activity		 EXP [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; kaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin]; kaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 PMID:32259555 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases expression		 EXP [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [Quercetin co-treated with kaempferol] results in increased expression of SOD1 protein
kaempferol results in increased expression of SOD1 protein		 CTD PMID:25111660 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
affects response to substance
increases expression		 ISO fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]
SOD2 protein affects the susceptibility to kaempferol		 CTD PMID:23526725 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOX9 SRY-box transcription factor 9 increases expression ISO kaempferol results in increased expression of SOX9 mRNA CTD PMID:23989061 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form] CTD PMID:18274639 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 multiple interactions EXP [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA CTD PMID:16797527 NCBI chr12:56,341,597...56,360,161
Ensembl chr12:56,341,597...56,360,167 		JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP kaempferol results in increased expression of TFAM mRNA CTD PMID:17327447 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
G TFF1 trefoil factor 1 increases expression
multiple interactions		 EXP kaempferol results in increased expression of TFF1 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]		 CTD PMID:14706564 PMID:23384675 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TGFA transforming growth factor alpha multiple interactions EXP kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] CTD PMID:10783318 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of TJP1 protein] CTD PMID:31785310 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,865
Ensembl chr15:29,699,367...29,968,865 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity		 ISO
EXP		 kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
kaempferol results in decreased activity of TNF protein
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]		 CTD PMID:15322261 PMID:15985724 PMID:16434028 PMID:16934226 PMID:16987811 PMID:18394220 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30769083 PMID:31306686 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TP53 tumor protein p53 multiple interactions
affects response to substance
increases phosphorylation
increases expression		 EXP
ISO		 Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]
TP53 protein affects the susceptibility to kaempferol
kaempferol results in increased expression of TP53 protein		 CTD PMID:19028473 PMID:22155320 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 increases expression EXP kaempferol results in increased expression of TP53I3 mRNA; kaempferol results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:24,077,428...24,085,767
Ensembl chr 2:24,077,433...24,085,861 		JBrowse link
G TP63 tumor protein p63 increases expression EXP kaempferol results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276 		JBrowse link
G TP73 tumor protein p73 increases expression EXP kaempferol results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201 		JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein] CTD PMID:30769083 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions EXP kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TSLP protein] CTD PMID:28711657 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026 		JBrowse link
G TUBB3 tubulin beta 3 class III decreases expression ISO kaempferol results in decreased expression of TUBB3 protein CTD PMID:26683311 NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761 		JBrowse link
G UCP1 uncoupling protein 1 multiple interactions ISO kaempferol inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961 		JBrowse link
G UCP3 uncoupling protein 3 increases expression EXP kaempferol results in increased expression of UCP3 mRNA CTD PMID:17327447 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
multiple interactions		 EXP
ISO		 UGT1A1 protein results in increased glucuronidation of kaempferol
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]		 CTD PMID:14557274 PMID:29574133 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 affects glucuronidation
increases glucuronidation		 EXP UGT1A3 mutant form affects the glucuronidation of kaempferol
UGT1A3 protein results in increased glucuronidation of kaempferol		 CTD PMID:16738032 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,938...233,773,299 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UTRN utrophin increases expression EXP kaempferol results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 6:144,284,955...144,853,034
Ensembl chr 6:144,285,701...144,853,034 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VDR vitamin D receptor increases activity EXP kaempferol results in increased activity of VDR protein CTD PMID:26366751 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
kaempferol 3-O-beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G2A phospholipase A2 group IIA affects activity EXP kaempferol-3-O-galactoside affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416 		JBrowse link
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22210036 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA] CTD PMID:22210036 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22210036 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22210036 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22210036 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22210036 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22210036 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22210036 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22210036 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
kuwanone G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression		 ISO geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]
kuwanon G results in increased expression of ABCB1 mRNA; kuwanon G results in increased expression of ABCB1 protein		 CTD PMID:29355567 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression		 ISO geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein]
kuwanon G results in increased expression of ABCG1 mRNA; kuwanon G results in increased expression of ABCG1 protein		 CTD PMID:29355567 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G APOE apolipoprotein E multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased uptake of Lipids] CTD PMID:29355567 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G GRP gastrin releasing peptide multiple interactions ISO kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr18:59,219,188...59,230,771
Ensembl chr18:59,220,158...59,230,774 		JBrowse link
G GRPR gastrin releasing peptide receptor multiple interactions ISO kuwanon G binds to and results in decreased activity of GRPR protein; kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr  X:16,123,565...16,153,518
Ensembl chr  X:16,123,565...16,153,518 		JBrowse link
G IFNG interferon gamma multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IFNG mRNA] CTD PMID:29355567 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL1B mRNA] CTD PMID:29355567 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 mRNA] CTD PMID:29355567 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of NFKBIA protein] CTD PMID:29355567 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression ISO kuwanon G results in increased expression of NR1H3 protein CTD PMID:29355567 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein] CTD PMID:29355567 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF mRNA] CTD PMID:29355567 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
kuwanone H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRP gastrin releasing peptide multiple interactions ISO kuwanon H inhibits the reaction [GRP protein binds to NMBR protein]
kuwanon H inhibits the reaction [GRP protein binds to GRPR protein]		 CTD PMID:7646517 NCBI chr18:59,219,188...59,230,771
Ensembl chr18:59,220,158...59,230,774 		JBrowse link
G GRPR gastrin releasing peptide receptor multiple interactions ISO kuwanon H binds to and results in decreased activity of GRPR protein; kuwanon H inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr  X:16,123,565...16,153,518
Ensembl chr  X:16,123,565...16,153,518 		JBrowse link
G NMBR neuromedin B receptor multiple interactions ISO kuwanon H inhibits the reaction [GRP protein binds to NMBR protein] CTD PMID:7646517 NCBI chr 6:142,074,484...142,147,122
Ensembl chr 6:142,058,330...142,088,799 		JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP Luteolin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Luteolin co-treated with Cisplatin] results in increased expression of ABCC2 protein; Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:23770416 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions ISO Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein] CTD PMID:23770416 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) affects activity EXP Luteolin affects the activity of ABCG2 protein CTD PMID:20403331 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Luteolin inhibits the reaction [cobaltous chloride results in increased activity of ACHE protein] CTD PMID:31362009 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:19747501 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions EXP Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP
ISO		 Luteolin binds to and results in decreased activity of AHR protein
Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]		 CTD PMID:14644660 PMID:20450880 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression		 EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased phosphorylation of AKT1 protein
Luteolin results in increased phosphorylation of AKT1 protein
Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
[Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased expression of AKT1 protein		 CTD PMID:18591783 PMID:18720166 PMID:19344998 PMID:20153296 PMID:20685402 PMID:21782929 PMID:22926442 PMID:25448439 PMID:27474067 PMID:27525270 PMID:32035215 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) multiple interactions EXP Luteolin inhibits the reaction [Tunicamycin results in increased expression of ASNS mRNA] CTD PMID:32407927 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542 		JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein modified form] CTD PMID:32407927 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070 		JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 Luteolin inhibits the reaction [Methamphetamine results in increased expression of ATG5 protein]
Luteolin results in increased expression of ATG5 protein		 CTD PMID:32035215 PMID:32268164 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BAX protein]
Luteolin results in increased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of BAX protein]		 CTD PMID:21601631 PMID:27474067 PMID:27525270 PMID:32035215 PMID:32268164 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of BCL2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2 protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] CTD PMID:19557821 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions		 EXP Luteolin results in decreased expression of BCL2L1 protein
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2L1 protein]		 CTD PMID:21601631 PMID:25448439 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
Luteolin results in increased expression of BECN1 protein		 CTD PMID:32035215 PMID:32268164 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15334063 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G CASP1 caspase 1 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased cleavage of CASP3 protein]; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Luteolin results in increased expression of and results in increased cleavage of CASP3 protein
Luteolin results in increased expression of CASP3 protein
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Luteolin results in increased activity of CASP3 protein
Luteolin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]		 CTD PMID:16140950 PMID:18331776 PMID:19397994 PMID:21074525 PMID:21601631 PMID:23770416 PMID:24525192 PMID:27474067 PMID:27489195 PMID:27525270 PMID:31288002 PMID:32035215 PMID:32268164 PMID:32407927 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP7 caspase 7 increases activity EXP Luteolin results in increased activity of CASP7 protein CTD PMID:21074525 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP
ISO		 [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]		 CTD PMID:15334063 PMID:16140950 PMID:24525192 PMID:27525270 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711 		JBrowse link
G CASP9 caspase 9 increases activity
increases cleavage		 EXP Luteolin results in increased activity of CASP9 protein
Luteolin results in increased cleavage of CASP9 protein		 CTD PMID:18331776 PMID:19397994 PMID:21601631 PMID:27474067 PMID:27489195 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase affects activity
decreases activity
multiple interactions		 EXP
ISO		 Luteolin affects the activity of CAT protein
Luteolin results in decreased activity of CAT protein
Fluorouracil promotes the reaction [Luteolin results in decreased activity of CAT protein]; Luteolin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Luteolin promotes the reaction [Fluorouracil results in decreased activity of CAT protein]		 CTD PMID:18503759 PMID:31288002 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCN5 cellular communication network factor 5 decreases expression EXP Luteolin results in decreased expression of CCN5 mRNA CTD PMID:19397994 NCBI chr20:44,714,204...44,728,041
Ensembl chr20:44,714,844...44,728,509 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Luteolin results in decreased expression of CCNA2 protein CTD PMID:22926442 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Luteolin results in decreased expression of CCNB1 mRNA; Luteolin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 PMID:22926442 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression		 ISO Fluorouracil promotes the reaction [Luteolin results in decreased expression of CCND1 protein]; Luteolin promotes the reaction [Fluorouracil results in decreased expression of CCND1 protein] CTD PMID:31288002 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD40 CD40 molecule multiple interactions EXP Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863 		JBrowse link
G CD74 CD74 molecule decreases expression EXP Luteolin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929 		JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein] CTD PMID:27474067 PMID:32268164 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541 		JBrowse link
G CDH2 cadherin 2 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein] CTD PMID:27474067 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDH5 cadherin 5 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CDH5 mRNA] CTD PMID:32035215 NCBI chr16:66,366,657...66,404,784
Ensembl chr16:66,366,622...66,404,784 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP Luteolin results in decreased expression of CDK1 protein CTD PMID:22926442 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases activity
decreases expression		 EXP Luteolin results in decreased activity of CDK2 protein
Luteolin results in decreased expression of CDK2 protein		 CTD PMID:11322924 PMID:22926442 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP
ISO		 Luteolin results in increased expression of CDKN1A mRNA; Luteolin results in increased expression of CDKN1A protein
Fluorouracil promotes the reaction [Luteolin results in increased expression of CDKN1A protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of CDKN1A protein]		 CTD PMID:11322924 PMID:11790449 PMID:19397994 PMID:22926442 PMID:31288002 PMID:32268164 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Luteolin results in increased expression of CDKN1B protein CTD PMID:11322924 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C decreases expression EXP Luteolin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of CHUK protein] CTD PMID:25448439 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CSF2 colony stimulating factor 2 decreases expression
multiple interactions		 EXP
ISO		 Luteolin results in decreased expression of CSF2 mRNA
Luteolin inhibits the reaction [Calcimycin results in increased expression of CSF2 mRNA]		 CTD PMID:10718847 PMID:17950587 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP Luteolin results in decreased expression of CTNNB1 protein CTD PMID:32268164 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CXCL12 mRNA] CTD PMID:32035215 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of CXCL8 protein] CTD PMID:25448439 PMID:30133131 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA] CTD PMID:19426678 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
decreases activity		 EXP
ISO		 Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Dust analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of CYP1A1 mRNA]
Luteolin results in increased expression of CYP1A1 mRNA
Luteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
Luteolin results in decreased activity of CYP1A1 protein		 CTD PMID:16263508 PMID:17090139 PMID:20403331 PMID:20930378 PMID:21482471 PMID:23994263 PMID:29584932 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP Luteolin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity
increases expression		 EXP Luteolin results in decreased activity of CYP1B1 protein
Luteolin results in increased expression of CYP1B1 mRNA		 CTD PMID:21482471 PMID:23994263 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP Luteolin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Luteolin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Luteolin inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:23770416 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO
EXP		 Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]; SESN2 protein promotes the reaction [Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]]		 CTD PMID:32407927 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DHRS11 dehydrogenase/reductase 11 decreases activity EXP Luteolin results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr17:36,591,846...36,600,804
Ensembl chr17:36,591,879...36,600,804 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions EXP Luteolin inhibits the reaction [Tunicamycin results in increased expression of DNAJB9 mRNA] CTD PMID:32407927 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850 		JBrowse link
G DRAM1 DNA damage regulated autophagy modulator 1 increases expression
multiple interactions		 ISO Luteolin results in increased expression of DRAM1 protein
Fluorouracil promotes the reaction [Luteolin results in increased expression of DRAM1 protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of DRAM1 protein]		 CTD PMID:31288002 NCBI chr12:101,877,327...101,923,623
Ensembl chr12:101,877,580...102,012,130 		JBrowse link
G EGF epidermal growth factor multiple interactions EXP EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of EGFR protein]; EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein] CTD PMID:10556937 PMID:12168845 PMID:15135307 PMID:22926442 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor decreases expression
multiple interactions
affects response to substance		 EXP Luteolin results in decreased expression of EGFR mRNA
EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of EGFR protein]; Luteolin affects the activity of and results in decreased phosphorylation of EGFR protein; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Luteolin results in decreased phosphorylation of and results in increased activity of EGFR protein
EGFR protein affects the susceptibility to Luteolin		 CTD PMID:10556937 PMID:12168845 PMID:15135307 PMID:22926442 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EGR1 early growth response 1 increases expression EXP Luteolin results in increased expression of EGR1 mRNA CTD PMID:19397994 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Luteolin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein] CTD PMID:32407927 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,151...67,386,516
Ensembl chr14:67,360,151...67,386,516 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Luteolin inhibits the reaction [Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of ERN1 protein] CTD PMID:32407927 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819 		JBrowse link
G ESR1 estrogen receptor 1 affects binding
multiple interactions		 EXP Luteolin binds to ESR1 protein
Luteolin inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:14579009 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 increases activity
affects binding		 EXP Luteolin results in increased activity of ESR2 protein
Luteolin binds to ESR2 protein		 CTD PMID:12224631 PMID:16860978 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G F11R F11 receptor multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of F11R mRNA] CTD PMID:32035215 NCBI chr 1:160,995,211...161,021,152
Ensembl chr 1:160,995,211...161,021,343 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO Luteolin inhibits the reaction [Tunicamycin results in increased expression of FASN mRNA] CTD PMID:32407927 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression EXP Luteolin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Luteolin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases activity		 EXP
ISO		 Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]
Luteolin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA]
Luteolin results in decreased activity of FOS protein		 CTD PMID:15322261 PMID:16343431 PMID:17950587 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit decreases activity EXP Luteolin results in decreased activity of FOSB protein CTD PMID:16343431 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP Luteolin results in increased expression of and results in increased phosphorylation of FOXO3 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of FOXO3 protein]; PD 0325901 promotes the reaction [Luteolin results in increased expression of FOXO3 protein] CTD PMID:32268164 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta increases expression EXP Luteolin results in increased expression of GADD45B mRNA; Luteolin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions		 ISO Luteolin results in increased expression of GCLC mRNA; Luteolin results in increased expression of GCLC protein
[Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide		 CTD PMID:22864849 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO Luteolin results in increased expression of GCLM mRNA; Luteolin results in increased expression of GCLM protein CTD PMID:22864849 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of GFAP protein] CTD PMID:19747501 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO [Luteolin co-treated with 4(G)-alpha-glucopyranosyl-rutin] inhibits the reaction [Doxorubicin results in decreased activity of GPX1 protein] CTD PMID:9242351 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358 		JBrowse link
G HBEGF heparin binding EGF like growth factor multiple interactions EXP Luteolin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
decreases activity		 EXP Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Luteolin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Luteolin results in increased expression of and results in increased activity of HIF1A protein
Luteolin results in decreased activity of HIF1A protein		 CTD PMID:19958256 PMID:20153296 PMID:25448439 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]
Luteolin results in increased expression of HMOX1 protein
Luteolin results in increased expression of HMOX1 mRNA; Luteolin results in increased expression of HMOX1 protein
[Luteolin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide		 CTD PMID:10975858 PMID:22864849 PMID:32268164 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO		 Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]
Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]		 CTD PMID:32407927 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15113938 PMID:15322261 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNB1 interferon beta 1 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:19426678 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma increases expression
multiple interactions		 ISO Luteolin results in increased expression of IFNG protein
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]		 CTD PMID:12755373 PMID:18090225 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO
EXP		 Luteolin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Luteolin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]		 CTD PMID:16934226 PMID:30016632 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA] CTD PMID:19426678 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487 		JBrowse link
G IL13 interleukin 13 multiple interactions ISO Luteolin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:17950587 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL17A interleukin 17A multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein] CTD PMID:25450234 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of IL1B protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]		 CTD PMID:18090225 PMID:18946510 PMID:19557821 PMID:20685402 PMID:24134915 PMID:25448439 PMID:25450234 PMID:30016632 PMID:31362009 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL27 interleukin 27 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA] CTD PMID:19426678 NCBI chr16:28,499,362...28,526,730
Ensembl chr16:28,499,362...28,512,051 		JBrowse link
G IL3 interleukin 3 multiple interactions ISO Luteolin inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA] CTD PMID:17950587 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204 		JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression		 EXP
ISO		 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4]
Luteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
Luteolin results in decreased expression of IL4 protein		 CTD PMID:12755373 PMID:16343431 PMID:16601352 PMID:17950587 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 decreases expression ISO Luteolin results in decreased expression of IL5 protein CTD PMID:12755373 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]		 CTD PMID:11123379 PMID:18720166 PMID:19426678 PMID:24134915 PMID:25448439 PMID:25450234 PMID:30016632 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INSR insulin receptor multiple interactions ISO Luteolin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:18591783 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides promotes the reaction [IRF3 protein binds to IRF3 protein]]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:19426678 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases phosphorylation		 EXP
ISO		 Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of JUN protein
Luteolin results in decreased phosphorylation of JUN protein		 CTD PMID:15322261 PMID:15334063 PMID:16343431 PMID:17950587 PMID:30133131 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit decreases activity EXP Luteolin results in decreased activity of JUNB protein CTD PMID:16343431 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit decreases activity EXP Luteolin results in decreased activity of JUND protein CTD PMID:16343431 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G MAOA monoamine oxidase A decreases activity
multiple interactions		 EXP
ISO		 Luteolin results in decreased activity of MAOA protein
Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]		 CTD PMID:23009399 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein; PD 0325901 inhibits the reaction [Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:32268164 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]
Luteolin results in decreased phosphorylation of MAPK1 protein
Luteolin results in increased activity of MAPK1 protein		 CTD PMID:10718847 PMID:15322261 PMID:17950587 PMID:17982879 PMID:19344998 PMID:19557821 PMID:22864849 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK10 mitogen-activated protein kinase 10 increases phosphorylation EXP Luteolin results in increased phosphorylation of MAPK10 protein CTD PMID:21601631 NCBI chr 4:86,010,405...86,594,625
Ensembl chr 4:85,990,007...86,594,625 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]
Luteolin results in decreased phosphorylation of MAPK3 protein
Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Luteolin results in increased activity of MAPK3 protein		 CTD PMID:10718847 PMID:17950587 PMID:17982879 PMID:19344998 PMID:19557821 PMID:20685402 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Luteolin results in increased phosphorylation of MAPK8 protein		 CTD PMID:10718847 PMID:15334063 PMID:21601631 PMID:30133131 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 EXP Luteolin results in increased phosphorylation of MAPK9 protein
Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]		 CTD PMID:21601631 PMID:30133131 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686 		JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression EXP Luteolin results in decreased expression of MMP1 mRNA; Luteolin results in decreased expression of MMP1 protein CTD PMID:21112745 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression
decreases secretion		 EXP
ISO		 Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of MMP9 protein]; Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein]
Luteolin results in increased expression of MMP9 protein
Luteolin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]
Luteolin results in decreased secretion of MMP9 protein		 CTD PMID:10556937 PMID:15135307 PMID:19747501 PMID:25448439 PMID:30133131 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NFAT5 nuclear factor of activated T cells 5 multiple interactions EXP Luteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] CTD PMID:26800359 NCBI chr16:69,565,952...69,704,654
Ensembl chr16:69,565,094...69,704,666 		JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases activity		 ISO
EXP		 [Luteolin results in increased activity of NFE2L2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; Luteolin affects the localization of and results in increased activity of NFE2L2 protein
[Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein		 CTD PMID:17982879 PMID:22864849 PMID:32407927 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO		 Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]		 CTD PMID:15334063 PMID:18090225 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]
Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]		 CTD PMID:11123379 PMID:15322261 PMID:16934226 PMID:18090225 PMID:19557821 PMID:25448439 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NFKBIB NFKB inhibitor beta multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] CTD PMID:15322261 NCBI chr19:38,899,503...38,908,894
Ensembl chr19:38,899,700...38,908,893 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 NCBI chr17:5,501,396...5,584,509
Ensembl chr17:5,499,427...5,619,424 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of NOS2 protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]		 CTD PMID:16934226 PMID:18090225 PMID:19426678 PMID:25448439 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO [Luteolin co-treated with linarin] results in increased expression of NOS3 protein modified form CTD PMID:29052401 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 decreases expression EXP Luteolin results in decreased expression of NR1D1 mRNA CTD PMID:19397994 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G P2RX4 purinergic receptor P2X 4 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein] CTD PMID:25450234 NCBI chr12:121,210,096...121,234,106
Ensembl chr12:121,209,861...121,234,106
Ensembl chr12:121,209,861...121,234,106 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP
ISO		 [Luteolin co-treated with Paclitaxel] results in decreased expression of PARP1 protein; PD 0325901 promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]
Luteolin inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form]		 CTD PMID:12168845 PMID:24525192 PMID:32268164 PMID:32407927 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of PDGFB mRNA] CTD PMID:32035215 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G PKM pyruvate kinase M1/2 increases activity EXP Luteolin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822 		JBrowse link
G PLK1 polo like kinase 1 decreases expression EXP Luteolin results in decreased expression of PLK1 protein CTD PMID:22926442 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367 		JBrowse link
G PRKCA protein kinase C alpha multiple interactions EXP Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] CTD PMID:30133131 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PSCA prostate stem cell antigen decreases expression EXP Luteolin results in decreased expression of PSCA mRNA CTD PMID:18331776 PMID:19397994 NCBI chr 8:142,670,297...142,682,725
Ensembl chr 8:142,670,308...142,682,725 		JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of PTGS2 protein]; Luteolin inhibits the reaction [Dust analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Dust results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 mRNA]
Luteolin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]		 CTD PMID:16263508 PMID:19557821 PMID:23770416 PMID:25448439 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions
decreases phosphorylation		 EXP EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of PTK2 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:15135307 PMID:25448439 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein] CTD PMID:25450234 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of and affects the localization of RELA protein]; Luteolin inhibits the reaction [Glucose affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein]
Luteolin inhibits the reaction [Cisplatin results in increased expression of RELA protein]
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]		 CTD PMID:15113938 PMID:15334063 PMID:18090225 PMID:19557821 PMID:23770416 PMID:25448439 PMID:30133131 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G SELE selectin E multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15113938 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SESN2 sestrin 2 multiple interactions
increases expression		 ISO
EXP		 Luteolin inhibits the reaction [Tunicamycin results in increased expression of SESN2 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of SESN2 protein]
[Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; SESN2 protein promotes the reaction [Luteolin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]]
Luteolin results in increased expression of SESN2 mRNA; Luteolin results in increased expression of SESN2 protein		 CTD PMID:32407927 NCBI chr 1:28,259,452...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G SFN stratifin increases expression EXP Luteolin results in increased expression of SFN mRNA; Luteolin results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate; [Luteolin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases activity EXP Luteolin results in decreased activity of SLC22A6 protein CTD PMID:32159797 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 decreases activity EXP Luteolin results in decreased activity of SLC22A8 protein CTD PMID:32159797 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 multiple interactions EXP [Luteolin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Luteolin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP Luteolin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr22:32,043,050...32,113,029
Ensembl chr22:32,043,261...32,113,029 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions
decreases activity		 EXP [Luteolin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin CTD PMID:32259555 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SOD1 superoxide dismutase 1 affects activity
multiple interactions		 EXP
ISO		 Luteolin affects the activity of SOD1 protein
Luteolin inhibits the reaction [Carbon Tetrachloride results in increased activity of SOD1 protein]		 CTD PMID:18503759 PMID:19747501 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Luteolin results in increased expression of SOD2 protein CTD PMID:32268164 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Luteolin inhibits the reaction [Tunicamycin results in increased expression of SREBF1 mRNA] CTD PMID:32407927 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation		 EXP Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of STAT3 protein]; Luteolin promotes the reaction [Paclitaxel results in decreased phosphorylation of STAT3 protein]; Paclitaxel promotes the reaction [Luteolin results in decreased phosphorylation of STAT3 protein] CTD PMID:24525192 PMID:25448439 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482 		JBrowse link
G TBK1 TANK binding kinase 1 decreases activity EXP Luteolin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr12:64,452,105...64,502,114
Ensembl chr12:64,452,092...64,502,114
Ensembl chr12:64,452,092...64,502,114 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO		 Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of TNF protein]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein]; Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]
Luteolin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Luteolin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Luteolin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]		 CTD PMID:11123379 PMID:15113938 PMID:15322261 PMID:15334063 PMID:16934226 PMID:17950587 PMID:18720166 PMID:19426678 PMID:19557821 PMID:23770416 PMID:25448439 PMID:25450234 PMID:30016632 PMID:31362009 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] CTD PMID:15334063 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312 		JBrowse link
G TNFSF10</