The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).
ethion results in increased expression of IL1B mRNA [ethion co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; Lipopolysaccharides promotes the reaction [ethion results in increased expression of IL1B mRNA]
ethion binds to and results in increased activity of NR1I2 protein [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; ethion binds to and results in increased activity of NR1I2 protein
[ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein
ethion results in increased expression of TLR9 mRNA [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 protein