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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethion
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Accession:CHEBI:38663 term browser browse the term
Definition:An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).
Synonyms:exact_synonym: O,O,O',O'-tetraethyl S,S'-methanediyl bis(phosphorodithioate)
 related_synonym: Bis(S-(diethoxyphosphinothioyl)mercapto)methane;   Formula=C9H22O4P2S4;   InChI=1S/C9H22O4P2S4/c1-5-10-14(16,11-6-2)18-9-19-15(17,12-7-3)13-8-4/h5-9H2,1-4H3;   InChIKey=RIZMRRKBZQXFOY-UHFFFAOYSA-N;   O,O,O',O'-Tetraethyl S,S'-methylenebis(phosphorodithioate);   O,O,O',O'-tetraethyl S,S'-methanediyl bis(dithiophosphate);   S,S'-Methylene bis(O,O-diethyl phosphorodithioate);   SMILES=CCOP(=S)(OCC)SCSP(=S)(OCC)OCC
 xref: Beilstein:1804530;   CAS:563-12-2;   KEGG:C18725
 xref_mesh: MESH:C100038
 xref: PMID:21366965;   PMID:21560835;   PMID:23127602;   PMID:24398360;   PMID:24401442;   PPDB:276;   Reaxys:1804530;   Wikipedia:Ethion



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ethion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethion results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO ethion results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO ethion results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO ethion results in increased expression of IL1B mRNA
[ethion co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; Lipopolysaccharides promotes the reaction [ethion results in increased expression of IL1B mRNA]
CTD PMID:30225615 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethion binds to and results in increased activity of NR1I2 protein
[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; ethion binds to and results in increased activity of NR1I2 protein
CTD PMID:21115097 PMID:25028461 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO ethion results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein CTD PMID:30225615 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 increases expression
multiple interactions
ISO ethion results in increased expression of TLR9 mRNA
[ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 protein
CTD PMID:30225615 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [ethion co-treated with Lipopolysaccharides] results in increased expression of TNF protein CTD PMID:30225615 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 affects activity ISO ethion metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19911
    role 19887
      application 19723
        agrochemical 16298
          ethion 11
Path 2
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  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    p-block element atom 19859
                      chalcogen 19605
                        oxygen atom 19579
                          oxygen molecular entity 19579
                            hydroxides 19382
                              oxoacid 18779
                                pnictogen oxoacid 13189
                                  phosphorus oxoacid 12433
                                    phosphoric acids 11428
                                      phosphoric acid 11428
                                        phosphoric acid derivative 11236
                                          phosphate 11235
                                            organic phosphate 11235
                                              organic thiophosphate 8624
                                                ethion 11
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