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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-methyladenine
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Accession:CHEBI:38635 term browser browse the term
Definition:A methyladenine that is adenine substituted with a methyl group at position N-3.
Synonyms:related_synonym: 3-METHYL-3H-PURIN-6-YLAMINE;   3-Methyl-3H-Purin-6-amine;   3-methyl-3H-adenine;   6-amino-3-methylpurine;   Formula=C6H7N5;   InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3;   InChIKey=FSASIHFSFGAIJM-UHFFFAOYSA-N;   SMILES=Cn1cnc(N)c2ncnc12
 alt_id: CHEBI:1590;   CHEBI:21828;   CHEBI:40596
 xref: Beilstein:146087;   CAS:5142-23-4;   DrugBank:DB04104;   Gmelin:279109;   HMDB:HMDB0011600;   KEGG:C00913;   LINCS:LSM-4733
 xref_mesh: MESH:C025946
 xref: MetaCyc:3-Methyl-Adenines;   PDBeChem:ADK;   PMID:16139832;   PMID:22770225;   PMID:23819759;   PMID:24297644;   PMID:24830781;   PMID:25708950;   Reaxys:146087;   Reaxys:6503822


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3-methyladenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein] CTD PMID:30677399 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP 3-methyladenine results in increased expression of AIFM1 protein CTD PMID:16497721 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO 3-methyladenine results in decreased phosphorylation of AKT1 protein
3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]
CTD PMID:16882451 PMID:32043704 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apod apolipoprotein D affects localization ISO 3-methyladenine affects the localization of APOD protein CTD PMID:28182653 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with 3-methyladenine] results in increased expression of APP protein CTD PMID:23726866 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase decreases expression ISO 3-methyladenine results in decreased expression of ATG4A mRNA CTD PMID:21681844 NCBI chr  X:112,328,907...112,403,157 JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression ISO 3-methyladenine results in decreased expression of ATG4B mRNA CTD PMID:21681844 NCBI chr 9:100,888,457...100,920,123
Ensembl chr 9:100,888,501...100,918,637
JBrowse link
G Atg5 autophagy related 5 multiple interactions
decreases expression
ISO
EXP
3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]
3-methyladenine results in decreased expression of ATG5 mRNA; 3-methyladenine results in decreased expression of ATG5 protein
3-methyladenine inhibits the reaction [aristolochic acid I results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]
CTD PMID:18818525 PMID:23939141 PMID:28184909 PMID:29128638 PMID:30611790 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA] CTD PMID:22902833 PMID:29078374 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5H mRNA] CTD PMID:29078374 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
3-methyladenine inhibits the reaction [citreoviridin results in increased expression of BAX protein]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]
3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]
CTD PMID:26804764 PMID:31419397 PMID:32043704 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2]; 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; [3-methyladenine co-treated with Amiodarone] results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]
CTD PMID:23912912 PMID:25110043 PMID:31419397 PMID:33002460 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [Fluorouracil results in increased expression of BCL2L1 protein]
3-methyladenine results in increased expression of BCL2L1 mRNA
CTD PMID:19116755 PMID:21681844 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
affects response to substance
decreases expression
ISO
EXP
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1]; 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]
BECN1 protein affects the susceptibility to 3-methyladenine
3-methyladenine results in decreased expression of BECN1 mRNA; 3-methyladenine results in decreased expression of BECN1 protein
CTD PMID:16497721 PMID:18619688 PMID:20525898 PMID:22322152 PMID:22902833 PMID:25110043 PMID:25622137 PMID:26804764 PMID:28025121 PMID:28130038 PMID:28184909 PMID:29518472 PMID:29923297 PMID:30365942 PMID:30555576 PMID:30611790 PMID:30629952 PMID:31421117 PMID:32043704 PMID:32061152 PMID:32687844 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO 3-methyladenine results in increased cleavage of BID protein CTD PMID:26853465 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO 3-methyladenine inhibits the reaction [YM 155 results in decreased expression of BIRC5 protein] CTD PMID:31837377 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO 3-methyladenine results in decreased expression of BNIP3 protein CTD PMID:26853465 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]
3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein]
3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]
CTD PMID:27611972 PMID:30205151 PMID:30237538 PMID:31586597 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]
3-methyladenine results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [astin B results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [Paraquat results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 3-methyladenine results in increased expression of and results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [3-methyladenine results in increased activity of CASP3 protein]; dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein]
3-methyladenine results in increased expression of CASP3 mRNA
CTD PMID:16497721 PMID:17341480 PMID:18818525 PMID:19116755 PMID:19139269 PMID:20104024 PMID:20426806 PMID:20929985 PMID:21681844 PMID:23380477 PMID:23799852 PMID:23912912 PMID:24321340 PMID:25078063 PMID:25219577 PMID:25266202 PMID:25639566 PMID:25939952 PMID:26804764 PMID:26822499 PMID:26853465 PMID:27057282 PMID:27413105 PMID:28219700 PMID:28483490 PMID:28722333 PMID:28802652 PMID:29902662 PMID:30465897 PMID:30629952 PMID:31226464 PMID:31421117 PMID:32043704 PMID:33002460 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases activity ISO 3-methyladenine results in increased activity of CASP4 protein CTD PMID:20371669 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO 3-methyladenine results in increased activity of CASP7 protein
3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]
CTD PMID:20371669 PMID:25078063 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]] CTD PMID:20104024 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]; [3-methyladenine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP9 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]
CTD PMID:16497721 PMID:20104024 PMID:20426806 PMID:23799852 PMID:24823293 PMID:28184909 PMID:28722333 PMID:29902662 PMID:31226464 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] CTD PMID:22927544 PMID:30555576 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression ISO 3-methyladenine results in increased expression of CDX2 mRNA CTD PMID:21681844 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA] CTD PMID:29078374 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] CTD PMID:24823293 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Ckb creatine kinase B multiple interactions EXP 3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:31419397 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP 3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:31419397 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Ctsb cathepsin B multiple interactions ISO 3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CTSB protein]; 3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Acrolein results in increased expression of CTSB protein] CTD PMID:23380477 PMID:29902662 PMID:30237538 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsl cathepsin L multiple interactions ISO 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein] CTD PMID:25639782 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 protein] CTD PMID:28867211 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein] CTD PMID:28867211 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein] CTD PMID:20929985 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein] CTD PMID:28245985 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation EXP 3-methyladenine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:26804764 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO 3-methyladenine inhibits the reaction [YM 155 results in decreased expression of and results in decreased stability of ELAVL1 mRNA]; 3-methyladenine inhibits the reaction [YM 155 results in decreased expression of ELAVL1 protein] CTD PMID:31837377 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Eno2 enolase 2 multiple interactions EXP 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein] CTD PMID:26676567 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of FTH1 protein]
3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]
CTD PMID:32687844 PMID:32937103 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gabarap GABA type A receptor-associated protein decreases expression ISO 3-methyladenine results in decreased expression of GABARAP mRNA CTD PMID:21681844 NCBI chr10:56,601,288...56,604,223
Ensembl chr10:56,601,288...56,604,221
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP 3-methyladenine inhibits the reaction [sodium arsenite results in decreased expression of GAP43] CTD PMID:25639566 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP 3-methyladenine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GJA1 protein] CTD PMID:33242459 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
ISO 3-methyladenine results in increased expression of GPT protein
TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]
CTD PMID:31513885 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein] CTD PMID:30362509 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gys1 glycogen synthase 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 NCBI chr 1:101,427,195...101,447,092
Ensembl chr 1:101,427,195...101,447,092
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO 3-methyladenine inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] CTD PMID:18927491 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein] CTD PMID:28245985 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:24145604 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il18 interleukin 18 multiple interactions ISO 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
3-methyladenine results in increased expression of IL1B mRNA
3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA]
3-methyladenine inhibits the reaction [lead acetate results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]
CTD PMID:27611972 PMID:30205151 PMID:30237538 PMID:31513885 PMID:31586597 PMID:32879255 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA]
3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
CTD PMID:28867211 PMID:29078374 PMID:31513885 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] CTD PMID:30362509 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin results in increased localization of and results in increased expression of ITGAM protein]; [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with 3-methyladenine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein] CTD PMID:20574048 PMID:28130038 PMID:29743969 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP1 protein] CTD PMID:31226464 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO 3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein] CTD PMID:31226464 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lgals1 galectin 1 multiple interactions ISO 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased susceptibility to Cisplatin]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form] CTD PMID:30365942 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 multiple interactions ISO 3-methyladenine inhibits the reaction [LRRK2 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:25017139 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
affects metabolic processing
ISO 3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3A protein modified form]
3-methyladenine affects the metabolism of MAP1LC3A protein
CTD PMID:20008137 PMID:21742779 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases expression
decreases cleavage
affects metabolic processing
ISO
EXP
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased metabolism of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Quercetin results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [YM 155 results in increased lipidation of MAP1LC3B protein]; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form
3-methyladenine results in decreased expression of MAP1LC3B mRNA
3-methyladenine results in decreased cleavage of MAP1LC3B protein
3-methyladenine affects the metabolism of MAP1LC3B protein
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine results in decreased expression of and results in decreased cleavage of MAP1LC3B protein
3-methyladenine results in decreased expression of MAP1LC3B mRNA; 3-methyladenine results in decreased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; cupric chloride inhibits the reaction [3-methyladenine results in decreased expression of MAP1LC3B protein modified form]
CTD PMID:18640276 PMID:20962572 PMID:21325019 PMID:21681844 PMID:22322152 PMID:23680031 PMID:24145604 PMID:25639782 PMID:26804720 PMID:28251795 PMID:28867211 PMID:29128638 PMID:29518472 PMID:30025493 PMID:30365942 PMID:30555576 PMID:30611790 PMID:30677399 PMID:31837377 PMID:32043704 PMID:32512069 PMID:32687844 PMID:32937103 PMID:33002460 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein] CTD PMID:26676567 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 affects response to substance
multiple interactions
ISO 3-methyladenine affects the susceptibility to MAP3K5 protein
3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]; 3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]
CTD PMID:20929985 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
ISO 3-methyladenine results in increased expression of MAPK1 protein modified form
3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]
CTD PMID:28483490 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
ISO 3-methyladenine results in increased expression of MAPK3 protein modified form
3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]
CTD PMID:28483490 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO 3-methyladenine inhibits the reaction [YM 155 results in decreased expression of MCL1 protein]; 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 PMID:31837377 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased expression of MMP9 protein]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:24145604 PMID:32043704 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases metabolic processing ISO MPG protein results in increased metabolism of 3-methyladenine CTD PMID:10626224 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 3-methyladenine inhibits the reaction [lead acetate results in increased expression of MPO protein] CTD PMID:32879255 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases expression
decreases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]
3-methyladenine results in increased expression of MTOR protein
3-methyladenine results in decreased phosphorylation of MTOR protein
CTD PMID:20929985 PMID:26804764 PMID:29518472 PMID:32043704 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nanog Nanog homeobox increases expression ISO 3-methyladenine results in increased expression of NANOG mRNA CTD PMID:21681844 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
CTD PMID:32687844 PMID:32937103 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
CTD PMID:29078374 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
CTD PMID:29078374 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA] CTD PMID:29078374 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions ISO 3-methyladenine inhibits the reaction [Chlorpyrifos results in decreased expression of NDUFS3 protein] CTD PMID:26070385 NCBI chr 3:79,721,686...79,728,863
Ensembl chr 3:79,721,694...79,728,879
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA] CTD PMID:29078374 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nefh neurofilament heavy multiple interactions ISO 3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFH protein] CTD PMID:23743148 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefl neurofilament light multiple interactions ISO 3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFL protein] CTD PMID:23743148 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein] CTD PMID:30205151 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO
EXP
3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein]
3-methyladenine inhibits the reaction [aristolochic acid I results in increased cleavage of PARP1 protein]
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; [3-methyladenine co-treated with Amiodarone] results in increased cleavage of PARP1 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of PARP1 protein; [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein
3-methyladenine results in increased cleavage of PARP1 protein
CTD PMID:19116755 PMID:21616090 PMID:21778691 PMID:23912912 PMID:23939141 PMID:24321340 PMID:24823293 PMID:24875536 PMID:25939952 PMID:28722333 PMID:30025493 PMID:31421117 PMID:33002460 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; [3-methyladenine results in decreased activity of PIK3C3 protein] which results in decreased susceptibility to Hydrogen Peroxide CTD PMID:20525898 PMID:21742779 PMID:25622137 PMID:32061152 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:32043704 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 3-methyladenine results in increased expression of POU5F1 protein CTD PMID:21681844 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein] CTD PMID:30677399 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:24145604 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein]
3-methyladenine promotes the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]
CTD PMID:28867211 PMID:31586597 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation EXP 3-methyladenine results in decreased phosphorylation of RPS6KB1 protein CTD PMID:26804764 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Snca synuclein alpha multiple interactions ISO 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein] CTD PMID:27133439 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO 3-methyladenine results in increased expression of SOX2 mRNA CTD PMID:21681844 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO
EXP
3-methyladenine results in increased expression of SQSTM1 protein
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Quercetin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [YM 155 results in decreased expression of SQSTM1 protein]; 3-methyladenine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]
CTD PMID:20574048 PMID:22927544 PMID:24833599 PMID:25943029 PMID:28025121 PMID:28251795 PMID:29128638 PMID:29307831 PMID:29518472 PMID:29923297 PMID:30362509 PMID:30365942 PMID:31734597 PMID:31837377 PMID:32061152 PMID:32702505 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:28802652 PMID:31734597 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form
3-methyladenine results in increased expression of TNF mRNA
3-methyladenine inhibits the reaction [lead acetate results in increased expression of TNF protein]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
CTD PMID:24145604 PMID:31513885 PMID:31586597 PMID:32879255 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP 3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein] CTD PMID:31419397 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO 3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein
3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]
CTD PMID:22927544 PMID:23380477 PMID:30555576 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 multiple interactions ISO TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA] CTD PMID:31513885 NCBI chr13:100,817,206...100,873,837
Ensembl chr13:100,817,359...100,873,890
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions EXP
ISO
3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of ULK1 protein] CTD PMID:29128638 PMID:29518472 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        inhibitor 18295
          autophagy inhibitor 669
            3-methyladenine 98
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteropolycyclic compound 17973
                                    organic heterobicyclic compound 16776
                                      imidazopyrimidine 5586
                                        purines 5584
                                          aminopurine 4418
                                            6-aminopurines 791
                                              adenine 785
                                                methyladenine 98
                                                  3-methyladenine 98
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