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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium channel blocker
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Accession:CHEBI:38633 term browser browse the term
Definition:An agent that inhibits sodium influx through cell membranes.
Synonyms:related_synonym: Na channel blocker;   sodium channel blockers


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amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLG plasminogen multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,191...7,110,555
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Capsaicin inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G TAC1 tachykinin precursor 1 increases secretion EXP Capsaicin results in increased secretion of TAC1 protein CTD PMID:10766449 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 909
    role 868
      biological role 868
        biophysical role 174
          membrane transport modulator 87
            sodium channel modulator 7
              sodium channel blocker 7
                5-(N,N-hexamethylene)amiloride 0
                5-(N-methyl-N-propyl)amiloride 0
                Evans blue 0
                Evans blue free acid 0
                amiloride + 4
                amiloride hydrochloride + 0
                amiloride hydrochloride dihydrate 0
                carbamazepine + 0
                cocaine 1
                diazoxide 0
                encainide + 0
                ethylisopropylamiloride 0
                icajine 0
                licarbazepine + 0
                paralytic shellfish toxin + 0
                phenytoin 0
                pilsicainide 0
                procainamide + 0
                quinidine + 0
                ranolazine 0
                saxitoxin + 0
                tocainide 0
                topiramate 0
                triamterene 0
                voltage-gated sodium channel blocker + 2
paths to the root