Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.4.3.4 (monoamine oxidase) inhibitor
go back to main search page
Accession:CHEBI:38623 term browser browse the term
Definition:An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
Synonyms:related_synonym: EC 1.4.3.4 (monoamine oxidase) inhibitors;   EC 1.4.3.4 inhibitor;   EC 1.4.3.4 inhibitors;   MAO A inhibitor;   MAO A inhibitors;   MAO B inhibitors;   MAO inhibitor;   MAO inhibitors;   MAO-B inhibitor;   adrenalin oxidase inhibitor;   adrenalin oxidase inhibitors;   adrenaline oxidase inhibitor;   adrenaline oxidase inhibitors;   amine oxidase (flavin-containing) inhibitor;   amine oxidase (flavin-containing) inhibitors;   amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor;   amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors;   amine:oxygen oxidoreductase (deaminating) inhibitor;   amine:oxygen oxidoreductase (deaminating) inhibitors;   epinephrine oxidase inhibitor;   epinephrine oxidase inhibitors;   monoamine oxidase A inhibitor;   monoamine oxidase A inhibitors;   monoamine oxidase B inhibitor;   monoamine oxidase B inhibitors;   monoamine oxidase inhibitor;   monoamine oxidase inhibitors;   monoamine:O2 oxidoreductase (deaminating) inhibitor;   monoamine:O2 oxidoreductase (deaminating) inhibitors;   serotonin deaminase inhibitor;   serotonin deaminase inhibitors;   tyraminase inhibitor;   tyraminase inhibitors;   tyramine oxidase inhibitor;   tyramine oxidase inhibitors
 xref: Wikipedia:Monoamine_oxidase_inhibitor


show annotations for term's descendants           Sort by:
 
5'-hydroxyomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein CTD PMID:10103034 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp2c37 cytochrome P450, family 2. subfamily c, polypeptide 37 multiple interactions EXP [CYP2C37 protein results in increased metabolism of Omeprazole] which results in increased chemical synthesis of 5-hydroxymethylomeprazole CTD PMID:30503582 NCBI chr19:39,992,424...40,012,243
Ensembl chr19:39,992,424...40,012,243
JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases response to substance
ISO
EXP
8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060, PMID:15641640, PMID:18608257, PMID:19966059, PMID:21195062 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
multiple interactions
EXP DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368, PMID:10199625 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nts neurotensin multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr10:102,481,756...102,490,418
Ensembl chr10:102,481,756...102,490,486
JBrowse link
aminoguanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 multiple interactions EXP pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein] CTD PMID:12161173 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein] CTD PMID:26723916, PMID:29148590 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr17:35,170,986...35,176,083
Ensembl chr17:35,170,991...35,176,068
JBrowse link
G Alb albumin multiple interactions ISO pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]
CTD PMID:12196478, PMID:22287321 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aoc1 amine oxidase, copper-containing 1 multiple interactions
decreases activity
ISO pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]
pimagedine results in decreased activity of AOC1 protein
CTD PMID:6218830, PMID:8144586 NCBI chr 6:48,895,255...48,909,188
Ensembl chr 6:48,872,896...48,909,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 decreases expression ISO pimagedine results in decreased expression of ATP2B1 mRNA CTD PMID:15003327 NCBI chr10:98,914,630...99,026,143
Ensembl chr10:98,914,406...99,026,143
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA] CTD PMID:28242320 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO pimagedine results in decreased expression of BAX protein CTD PMID:19266598 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP
ISO
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein
CTD PMID:16980304, PMID:17135264, PMID:17786558 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:14729435 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 multiple interactions ISO pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein] CTD PMID:15545282 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO
pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]
CTD PMID:17786558, PMID:19556603 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
decreases expression
ISO [pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein
CTD PMID:12123627, PMID:19107871, PMID:19266598, PMID:19481068, PMID:22287321 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein decreases expression ISO pimagedine results in decreased expression of CAV1 protein CTD PMID:19706615 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Cd34 CD34 antigen decreases expression ISO pimagedine results in decreased expression of CD34 protein CTD PMID:19266598 NCBI chr 1:194,938,821...194,961,292
Ensembl chr 1:194,938,819...194,961,279
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein] CTD PMID:19061877 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO pimagedine results in increased expression of COL1A1 mRNA CTD PMID:18380797 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP pimagedine results in decreased phosphorylation of CREB1 protein CTD PMID:17135264 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 multiple interactions EXP [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein CTD PMID:17138957 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] CTD PMID:18594475 NCBI chr 8:122,424,771...122,432,940
Ensembl chr 8:122,424,776...122,432,930
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA] CTD PMID:9853001 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] CTD PMID:18594475 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide multiple interactions ISO pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein] CTD PMID:11500085 NCBI chr 8:3,680,280...3,694,174
Ensembl chr 8:3,681,737...3,694,175
JBrowse link
G Fmo1 flavin containing monooxygenase 1 multiple interactions ISO pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein] CTD PMID:10462538 NCBI chr 1:162,829,561...162,866,610
Ensembl chr 1:162,829,561...162,866,610
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA] CTD PMID:12763045 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein] CTD PMID:20826152 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP
ISO
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:26723916, PMID:28919305, PMID:29148590 NCBI chr17:30,592,861...30,612,659
Ensembl chr17:30,584,936...30,626,871
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) multiple interactions EXP pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA] CTD PMID:12763045 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions EXP pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA] CTD PMID:12763045 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions EXP pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein] CTD PMID:25406100 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein] CTD PMID:29148590 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
CTD PMID:7689037, PMID:11498278, PMID:12612912, PMID:12892526, PMID:12911628, PMID:28242320 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]
CTD PMID:11500085, PMID:12123627, PMID:25406100, PMID:28223158, PMID:28919305 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]
CTD PMID:25042521, PMID:26723916, PMID:28223158, PMID:29148590 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:12473873 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:12473873 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO pimagedine results in decreased expression of MKI67 mRNA CTD PMID:19266598 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO pimagedine results in increased expression of MMP13 mRNA CTD PMID:18380797 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) increases expression ISO pimagedine results in increased expression of MMP14 mRNA CTD PMID:18380797 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA] CTD PMID:18594475 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11713966, PMID:18209962 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial affects activity
affects expression
ISO pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA
CTD PMID:17936468 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal affects expression ISO pimagedine affects the expression of NOS1 mRNA CTD PMID:22777123 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
affects expression
decreases expression
decreases activity
EXP
ISO
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
CTD PMID:9306416, PMID:9810145, PMID:9853001, PMID:11574821, PMID:12054156, PMID:12473873, PMID:12892526, PMID:14550746, PMID:14729435, PMID:15821589, PMID:17135264, PMID:17138957, PMID:17637181, PMID:17936468, PMID:18594475, PMID:19266598, PMID:19481068, PMID:20455021, PMID:20463352, PMID:21397503, PMID:22777123, PMID:22961095, PMID:25406100, PMID:28223158, PMID:29935243 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell affects expression
multiple interactions
EXP pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]
CTD PMID:18483403 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein] CTD PMID:12763045 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Plat plasminogen activator, tissue multiple interactions ISO pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] CTD PMID:10856522 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP
ISO
[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD PMID:26723916, PMID:28919305 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA] CTD PMID:28242320 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA] CTD PMID:28242320 NCBI chr 1:180,227,004...180,263,467
Ensembl chr 1:180,227,004...180,263,438
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein CTD PMID:15067210, PMID:17637181, PMID:29935243 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein] CTD PMID:29935243 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G S100b S100 protein, beta polypeptide, neural multiple interactions ISO pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein] CTD PMID:19494442 NCBI chr10:76,253,836...76,261,319
Ensembl chr10:76,253,853...76,261,159
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions
increases expression
ISO pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA
CTD PMID:10856522, PMID:18380797 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression ISO pimagedine results in decreased expression of SOD1 protein CTD PMID:19266598 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
decreases expression
EXP
ISO
pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein
CTD PMID:18483403, PMID:19266598 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein] CTD PMID:19061877 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]
CTD PMID:18380797, PMID:25406100 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO pimagedine results in increased expression of TIMP1 mRNA CTD PMID:18380797 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:12123627, PMID:12612912, PMID:22287321, PMID:25042521, PMID:25406100, PMID:26723916, PMID:28223158 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions EXP TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]] CTD PMID:14550746 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions EXP pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA] CTD PMID:12763045 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid] CTD PMID:17880178 NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
clorgyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP-binding cassette, sub-family A (ABC1), member 5 increases expression ISO Clorgyline results in increased expression of ABCA5 mRNA CTD PMID:19691856 NCBI chr11:110,269,369...110,337,723
Ensembl chr11:110,269,369...110,337,716
JBrowse link
G Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain increases expression ISO Clorgyline results in increased expression of ACADSB mRNA CTD PMID:19691856 NCBI chr 7:131,410,601...131,446,211
Ensembl chr 7:131,410,601...131,448,944
JBrowse link
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression ISO Clorgyline results in increased expression of ACAP2 mRNA CTD PMID:19691856 NCBI chr16:31,092,412...31,201,285
Ensembl chr16:31,092,412...31,201,245
JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression ISO Clorgyline results in increased expression of ADRB2 mRNA CTD PMID:19691856 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Akap11 A kinase (PRKA) anchor protein 11 increases expression ISO Clorgyline results in increased expression of AKAP11 mRNA CTD PMID:19691856 NCBI chr14:78,492,246...78,536,980
Ensembl chr14:78,492,246...78,536,808
JBrowse link
G Akap9 A kinase (PRKA) anchor protein (yotiao) 9 increases expression ISO Clorgyline results in increased expression of AKAP9 mRNA CTD PMID:19691856 NCBI chr 5:3,927,736...4,080,204
Ensembl chr 5:3,928,054...4,081,310
JBrowse link
G Ankrd12 ankyrin repeat domain 12 increases expression ISO Clorgyline results in increased expression of ANKRD12 mRNA CTD PMID:19691856 NCBI chr17:65,965,703...66,078,804
Ensembl chr17:65,965,698...66,077,089
JBrowse link
G Apc APC, WNT signaling pathway regulator increases expression ISO Clorgyline results in increased expression of APC mRNA CTD PMID:19691856 NCBI chr18:34,220,297...34,322,190
Ensembl chr18:34,220,924...34,322,552
JBrowse link
G Ar androgen receptor increases expression ISO Clorgyline results in increased expression of AR mRNA CTD PMID:19691856 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 increases expression ISO Clorgyline results in increased expression of ARAP2 mRNA CTD PMID:19691856 NCBI chr 5:62,602,445...62,766,192
Ensembl chr 5:62,602,445...62,766,159
JBrowse link
G Arid4a AT rich interactive domain 4A (RBP1-like) increases expression ISO Clorgyline results in increased expression of ARID4A mRNA CTD PMID:19691856 NCBI chr12:71,015,081...71,099,351
Ensembl chr12:71,015,990...71,098,592
JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase increases expression ISO Clorgyline results in increased expression of ATG4C mRNA CTD PMID:19691856 NCBI chr 4:99,189,159...99,297,258
Ensembl chr 4:99,193,934...99,259,787
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Clorgyline results in increased expression of ATRX mRNA CTD PMID:19691856 NCBI chr  X:105,797,615...105,929,372
Ensembl chr  X:105,797,615...105,929,403
JBrowse link
G Azi2 5-azacytidine induced gene 2 increases expression ISO Clorgyline results in increased expression of AZI2 mRNA CTD PMID:19691856 NCBI chr 9:118,040,442...118,069,798
Ensembl chr 9:118,040,499...118,069,794
JBrowse link
G B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 increases expression ISO Clorgyline results in increased expression of B3GNT5 mRNA CTD PMID:19691856 NCBI chr16:19,760,192...19,772,760
Ensembl chr16:19,760,208...19,772,753
JBrowse link
G Baz2b bromodomain adjacent to zinc finger domain, 2B increases expression ISO Clorgyline results in increased expression of BAZ2B mRNA CTD PMID:19691856 NCBI chr 2:59,899,363...60,209,913
Ensembl chr 2:59,899,363...60,209,839
JBrowse link
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression ISO Clorgyline results in increased expression of BDP1 mRNA CTD PMID:19691856 NCBI chr13:100,017,994...100,104,090
Ensembl chr13:100,017,994...100,104,070
JBrowse link
G Bod1l biorientation of chromosomes in cell division 1-like increases expression ISO Clorgyline results in increased expression of BOD1L1 mRNA CTD PMID:19691856 NCBI chr 5:41,787,538...41,844,355
Ensembl chr 5:41,787,538...41,844,315
JBrowse link
G Brwd1 bromodomain and WD repeat domain containing 1 increases expression ISO Clorgyline results in increased expression of BRWD1 mRNA CTD PMID:19691856 NCBI chr16:95,992,089...96,082,703
Ensembl chr16:95,992,092...96,082,526
JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit increases expression ISO Clorgyline results in increased expression of CACNB2 mRNA CTD PMID:19691856 NCBI chr 2:14,603,861...14,988,811
Ensembl chr 2:14,603,088...14,987,908
JBrowse link
G Cbln2 cerebellin 2 precursor protein increases expression ISO Clorgyline results in increased expression of CBLN2 mRNA CTD PMID:19691856 NCBI chr18:86,711,061...86,718,283
Ensembl chr18:86,711,110...86,718,283
JBrowse link
G Ccdc112 coiled-coil domain containing 112 increases expression ISO Clorgyline results in increased expression of CCDC112 mRNA CTD PMID:19691856 NCBI chr18:46,282,151...46,311,950
Ensembl chr18:46,282,151...46,311,928
JBrowse link
G Cdh23 cadherin 23 (otocadherin) increases expression ISO Clorgyline results in increased expression of CDH23 mRNA CTD PMID:19691856 NCBI chr10:60,302,748...60,696,513
Ensembl chr10:60,302,748...60,696,490
JBrowse link
G Cenpc1 centromere protein C1 increases expression ISO Clorgyline results in increased expression of CENPC mRNA CTD PMID:19691856 NCBI chr 5:86,012,018...86,065,962
Ensembl chr 5:86,012,024...86,065,583
JBrowse link
G Cep135 centrosomal protein 135 increases expression ISO Clorgyline results in increased expression of CEP135 mRNA CTD PMID:19691856 NCBI chr 5:76,588,653...76,646,466
Ensembl chr 5:76,588,698...76,646,466
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO Clorgyline results in increased expression of CEP290 mRNA CTD PMID:19691856 NCBI chr10:100,487,548...100,575,671
Ensembl chr10:100,487,558...100,574,840
JBrowse link
G Cep350 centrosomal protein 350 increases expression ISO Clorgyline results in increased expression of CEP350 mRNA CTD PMID:19691856 NCBI chr 1:155,844,964...155,973,270
Ensembl chr 1:155,844,964...155,973,255
JBrowse link
G Cep70 centrosomal protein 70 increases expression ISO Clorgyline results in increased expression of CEP70 mRNA CTD PMID:19691856 NCBI chr 9:99,183,584...99,325,879
Ensembl chr 9:99,243,367...99,300,404
JBrowse link
G Cfh complement component factor h increases expression ISO Clorgyline results in increased expression of CFH mRNA CTD PMID:19691856 NCBI chr 1:140,085,855...140,183,411
Ensembl chr 1:140,084,708...140,183,764
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 increases expression ISO Clorgyline results in increased expression of CHD9 mRNA CTD PMID:19691856 NCBI chr 8:90,828,302...91,054,516
Ensembl chr 8:90,828,352...91,054,516
JBrowse link
G Chic1 cysteine-rich hydrophobic domain 1 increases expression ISO Clorgyline results in increased expression of CHIC1 mRNA CTD PMID:19691856 NCBI chr  X:103,356,403...103,409,092
Ensembl chr  X:103,356,476...103,396,092
JBrowse link
G Chm choroidermia (RAB escort protein 1) increases expression ISO Clorgyline results in increased expression of CHM mRNA CTD PMID:19691856 NCBI chr  X:113,040,592...113,185,539
Ensembl chr  X:113,040,593...113,185,517
JBrowse link
G Clgn calmegin increases expression ISO Clorgyline results in increased expression of CLGN mRNA CTD PMID:19691856 NCBI chr 8:83,389,790...83,428,552
Ensembl chr 8:83,389,867...83,428,552
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO Clorgyline results in increased expression of CLIP1 mRNA CTD PMID:19691856 NCBI chr 5:123,577,794...123,684,606
Ensembl chr 5:123,577,795...123,684,618
JBrowse link
G Cntn3 contactin 3 increases expression ISO Clorgyline results in increased expression of CNTN3 mRNA CTD PMID:19691856 NCBI chr 6:102,163,304...102,564,614
Ensembl chr 6:102,162,655...102,573,101
JBrowse link
G Cobll1 Cobl-like 1 increases expression ISO Clorgyline results in increased expression of COBLL1 mRNA CTD PMID:19691856 NCBI chr 2:65,088,339...65,239,398
Ensembl chr 2:65,088,339...65,239,403
JBrowse link
G Cpd carboxypeptidase D increases expression ISO Clorgyline results in increased expression of CPD mRNA CTD PMID:19691856 NCBI chr11:76,777,208...76,847,008
Ensembl chr11:76,778,424...76,847,018
JBrowse link
G Cpne9 copine family member IX increases expression ISO Clorgyline results in increased expression of CPNE9 mRNA CTD PMID:19691856 NCBI chr 6:113,282,283...113,305,571
Ensembl chr 6:113,282,307...113,305,627
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity
multiple interactions
ISO Clorgyline results in decreased activity of CYP2B6 protein
Clorgyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:25656918 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Dkkl1 dickkopf-like 1 increases expression ISO Clorgyline results in increased expression of DKKL1 mRNA CTD PMID:19691856 NCBI chr 7:45,207,525...45,212,165
Ensembl chr 7:45,207,519...45,212,147
JBrowse link
G Dmxl1 Dmx-like 1 increases expression ISO Clorgyline results in increased expression of DMXL1 mRNA CTD PMID:19691856 NCBI chr18:49,832,590...49,965,473
Ensembl chr18:49,832,670...49,965,473
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression ISO Clorgyline results in increased expression of DNAJC10 mRNA CTD PMID:19691856 NCBI chr 2:80,315,446...80,354,055
Ensembl chr 2:80,315,466...80,354,043
JBrowse link
G Dst dystonin increases expression ISO Clorgyline results in increased expression of DST mRNA CTD PMID:19691856 NCBI chr 1:33,907,888...34,308,662
Ensembl chr 1:33,908,225...34,308,661
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 increases expression ISO Clorgyline results in increased expression of DYNC2H1 mRNA CTD PMID:19691856 NCBI chr 9:6,928,550...7,178,306
Ensembl chr 9:6,928,503...7,184,446
JBrowse link
G Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 increases expression ISO Clorgyline results in increased expression of DYNC2LI1 mRNA CTD PMID:19691856 NCBI chr17:84,626,475...84,655,568
Ensembl chr17:84,626,496...84,655,588
JBrowse link
G Echdc1 enoyl Coenzyme A hydratase domain containing 1 increases expression ISO Clorgyline results in increased expression of ECHDC1 mRNA CTD PMID:19691856 NCBI chr10:29,298,144...29,346,661
Ensembl chr10:29,313,166...29,347,469
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression ISO Clorgyline results in increased expression of ESCO1 mRNA CTD PMID:19691856 NCBI chr18:10,566,507...10,610,863
Ensembl chr18:10,566,507...10,610,352
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO Clorgyline results in decreased expression of EZH2 mRNA CTD PMID:19691856 NCBI chr 6:47,530,274...47,595,270
Ensembl chr 6:47,530,139...47,595,341
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO Clorgyline results in increased expression of FAS mRNA CTD PMID:19691856 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fzd3 frizzled class receptor 3 increases expression ISO Clorgyline results in increased expression of FZD3 mRNA CTD PMID:19691856 NCBI chr14:65,192,441...65,262,463
Ensembl chr14:65,192,449...65,262,463
JBrowse link
G Gabpa GA repeat binding protein, alpha increases expression ISO Clorgyline results in increased expression of GABPA mRNA CTD PMID:19691856 NCBI chr16:84,834,891...84,863,783
Ensembl chr16:84,834,925...84,863,779
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Clorgyline results in decreased expression of GAP43 protein CTD PMID:12480131 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651
JBrowse link
G Gcc2 GRIP and coiled-coil domain containing 2 increases expression ISO Clorgyline results in increased expression of GCC2 mRNA CTD PMID:19691856 NCBI chr10:58,255,408...58,305,599
Ensembl chr10:58,255,497...58,305,599
JBrowse link
G Gk glycerol kinase increases expression ISO Clorgyline results in increased expression of GK mRNA CTD PMID:19691856 NCBI chr  X:85,701,937...85,776,819
Ensembl chr  X:85,701,937...85,776,819
JBrowse link
G Gnpda2 glucosamine-6-phosphate deaminase 2 increases expression ISO Clorgyline results in increased expression of GNPDA2 mRNA CTD PMID:19691856 NCBI chr 5:69,574,998...69,592,332
Ensembl chr 5:69,573,108...69,592,340
JBrowse link
G Golga4 golgi autoantigen, golgin subfamily a, 4 increases expression ISO Clorgyline results in increased expression of GOLGA4 mRNA CTD PMID:19691856 NCBI chr 9:118,506,196...118,582,519
Ensembl chr 9:118,506,267...118,582,519
JBrowse link
G Golgb1 golgi autoantigen, golgin subfamily b, macrogolgin 1 increases expression ISO Clorgyline results in increased expression of GOLGB1 mRNA CTD PMID:19691856 NCBI chr16:36,875,093...36,933,085
Ensembl chr16:36,875,140...36,933,085
JBrowse link
G Hint3 histidine triad nucleotide binding protein 3 increases expression ISO Clorgyline results in increased expression of HINT3 mRNA CTD PMID:19691856 NCBI chr10:30,603,195...30,623,530
Ensembl chr10:30,608,141...30,629,632
JBrowse link
G Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase increases expression ISO Clorgyline results in increased expression of IBTK mRNA CTD PMID:19691856 NCBI chr 9:85,687,359...85,750,703
Ensembl chr 9:85,687,360...85,749,334
JBrowse link
G Ift80 intraflagellar transport 80 increases expression ISO Clorgyline results in increased expression of IFT80 mRNA CTD PMID:19691856 NCBI chr 3:68,892,499...69,004,680
Ensembl chr 3:68,892,499...69,004,570
JBrowse link
G Klhdc1 kelch domain containing 1 increases expression ISO Clorgyline results in increased expression of KLHDC1 mRNA CTD PMID:19691856 NCBI chr12:69,227,729...69,284,646
Ensembl chr12:69,241,176...69,284,632
JBrowse link
G Klhl2 kelch-like 2, Mayven increases expression ISO Clorgyline results in increased expression of KLHL2 mRNA CTD PMID:19691856 NCBI chr 8:64,739,673...64,850,169
Ensembl chr 8:64,739,675...64,850,017
JBrowse link
G Ktn1 kinectin 1 increases expression ISO Clorgyline results in increased expression of KTN1 mRNA CTD PMID:19691856 NCBI chr14:47,648,274...47,736,564
Ensembl chr14:47,648,448...47,739,894
JBrowse link
G Larp1b La ribonucleoprotein domain family, member 1B increases expression ISO Clorgyline results in increased expression of LARP1B mRNA CTD PMID:19691856 NCBI chr 3:40,949,770...41,040,207
Ensembl chr 3:40,949,828...41,040,234
JBrowse link
G Lig4 ligase IV, DNA, ATP-dependent increases expression ISO Clorgyline results in increased expression of LIG4 mRNA CTD PMID:19691856 NCBI chr 8:9,970,020...9,977,680
Ensembl chr 8:9,969,049...9,977,686
JBrowse link
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) increases expression ISO Clorgyline results in increased expression of LRAT mRNA CTD PMID:19691856 NCBI chr 3:82,892,582...82,903,974
Ensembl chr 3:82,892,579...82,903,973
JBrowse link
G Ltb lymphotoxin B increases expression ISO Clorgyline results in increased expression of LTB mRNA CTD PMID:19691856 NCBI chr17:35,194,507...35,196,305
Ensembl chr17:35,194,439...35,196,320
JBrowse link
G Magea3 MAGE family member A3 increases expression ISO Clorgyline results in increased expression of MAGEA3 mRNA CTD PMID:19691856 NCBI chr  X:154,948,180...154,959,031
Ensembl chr  X:154,948,543...154,949,505
JBrowse link
G Manea mannosidase, endo-alpha increases expression ISO Clorgyline results in increased expression of MANEA mRNA CTD PMID:19691856 NCBI chr 4:26,324,506...26,346,918
Ensembl chr 4:26,324,506...26,346,891
JBrowse link
G Maoa monoamine oxidase A multiple interactions
decreases activity
EXP
ISO
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; [Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine
Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]
CTD PMID:1905457, PMID:3961266, PMID:12818349, PMID:16252076, PMID:21923181, PMID:23009399, PMID:23499958, PMID:27270453, PMID:30036687 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Maob monoamine oxidase B decreases activity
multiple interactions
EXP Clorgyline results in decreased activity of MAOB protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:23499958, PMID:23943324 NCBI chr  X:16,709,281...16,817,366
Ensembl chr  X:16,709,282...16,817,366
JBrowse link
G Map9 microtubule-associated protein 9 increases expression ISO Clorgyline results in increased expression of MAP9 mRNA CTD PMID:19691856 NCBI chr 3:82,358,072...82,395,268
Ensembl chr 3:82,358,044...82,395,268
JBrowse link
G Mbnl2 muscleblind like splicing factor 2 increases expression ISO Clorgyline results in increased expression of MBNL2 mRNA CTD PMID:19691856 NCBI chr14:120,275,652...120,431,698
Ensembl chr14:120,275,669...120,431,697
JBrowse link
G Mia2 MIA SH3 domain ER export factor 2 increases expression ISO Clorgyline results in increased expression of MIA2 mRNA CTD PMID:19691856 NCBI chr12:59,095,582...59,190,220
Ensembl chr12:59,095,799...59,191,583
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases expression ISO Clorgyline results in increased expression of MIPOL1 mRNA CTD PMID:19691856 NCBI chr12:57,230,425...57,457,241
Ensembl chr12:57,230,427...57,497,199
JBrowse link
G Mob1b MOB kinase activator 1B increases expression ISO Clorgyline results in increased expression of MOB1B mRNA CTD PMID:19691856 NCBI chr 5:88,720,871...88,758,455
Ensembl chr 5:88,720,855...88,764,220
JBrowse link
G Mon2 MON2 homolog, regulator of endosome to Golgi trafficking increases expression ISO Clorgyline results in increased expression of MON2 mRNA CTD PMID:19691856 NCBI chr10:122,992,060...123,076,505
Ensembl chr10:122,992,060...123,076,505
JBrowse link
G Mospd2 motile sperm domain containing 2 increases expression ISO Clorgyline results in increased expression of MOSPD2 mRNA CTD PMID:19691856 NCBI chr  X:164,936,169...164,980,505
Ensembl chr  X:164,936,169...164,980,375
JBrowse link
G Mpp7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) increases expression ISO Clorgyline results in increased expression of MPP7 mRNA CTD PMID:19691856 NCBI chr18:7,347,962...7,626,889
Ensembl chr18:7,347,959...7,626,866
JBrowse link
G Myo6 myosin VI increases expression ISO Clorgyline results in increased expression of MYO6 mRNA CTD PMID:19691856 NCBI chr 9:80,164,976...80,311,729
Ensembl chr 9:80,165,031...80,311,729
JBrowse link
G Ndfip2 Nedd4 family interacting protein 2 increases expression ISO Clorgyline results in increased expression of NDFIP2 mRNA CTD PMID:19691856 NCBI chr14:105,258,591...105,309,298
Ensembl chr14:105,258,573...105,309,298
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO Clorgyline results in increased expression of NFE2L2 mRNA CTD PMID:19691856 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nipbl NIPBL cohesin loading factor increases expression ISO Clorgyline results in increased expression of NIPBL mRNA CTD PMID:19691856 NCBI chr15:8,289,824...8,465,315
Ensembl chr15:8,290,617...8,444,463
JBrowse link
G Npat nuclear protein in the AT region increases expression ISO Clorgyline results in increased expression of NPAT mRNA CTD PMID:19691856 NCBI chr 9:53,536,889...53,575,627
Ensembl chr 9:53,537,047...53,574,342
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Clorgyline results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Clorgyline results in increased expression of NRIP1 mRNA CTD PMID:19691856 NCBI chr16:76,287,403...76,373,827
Ensembl chr16:76,287,400...76,373,827
JBrowse link
G Nsrp1 nuclear speckle regulatory protein 1 increases expression ISO Clorgyline results in increased expression of NSRP1 mRNA CTD PMID:19691856 NCBI chr11:77,044,292...77,078,437
Ensembl chr11:77,044,292...77,078,435
JBrowse link
G Nsun3 NOL1/NOP2/Sun domain family member 3 increases expression ISO Clorgyline results in increased expression of NSUN3 mRNA CTD PMID:19691856 NCBI chr16:62,732,444...62,786,884
Ensembl chr16:62,732,444...62,786,818
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression ISO Clorgyline results in increased expression of NT5DC1 mRNA CTD PMID:19691856 NCBI chr10:34,303,609...34,418,589
Ensembl chr10:34,288,288...34,418,552
JBrowse link
G Nudcd1 NudC domain containing 1 increases expression ISO Clorgyline results in increased expression of NUDCD1 mRNA CTD PMID:19691856 NCBI chr15:44,375,227...44,428,307
Ensembl chr15:44,373,163...44,428,307
JBrowse link
G Odf2l outer dense fiber of sperm tails 2-like increases expression ISO Clorgyline results in increased expression of ODF2L mRNA CTD PMID:19691856 NCBI chr 3:145,118,569...145,153,915
Ensembl chr 3:145,118,588...145,153,915
JBrowse link
G Pcm1 pericentriolar material 1 increases expression ISO Clorgyline results in increased expression of PCM1 mRNA CTD PMID:19691856 NCBI chr 8:41,239,484...41,334,088
Ensembl chr 8:41,239,752...41,332,344
JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 increases expression ISO Clorgyline results in increased expression of PCMTD1 mRNA CTD PMID:19691856 NCBI chr 1:7,087,077...7,173,628
Ensembl chr 1:7,088,920...7,173,628
JBrowse link
G Pdik1l PDLIM1 interacting kinase 1 like increases expression ISO Clorgyline results in increased expression of PDIK1L mRNA CTD PMID:19691856 NCBI chr 4:134,275,002...134,287,846
Ensembl chr 4:134,275,002...134,287,895
JBrowse link
G Phf14 PHD finger protein 14 increases expression ISO Clorgyline results in increased expression of PHF14 mRNA CTD PMID:19691856 NCBI chr 6:11,907,725...12,100,156
Ensembl chr 6:11,907,809...12,081,205
JBrowse link
G Phf3 PHD finger protein 3 increases expression ISO Clorgyline results in increased expression of PHF3 mRNA CTD PMID:19691856 NCBI chr 1:30,802,342...30,873,922
Ensembl chr 1:30,802,339...30,873,921
JBrowse link
G Phip pleckstrin homology domain interacting protein increases expression ISO Clorgyline results in increased expression of PHIP mRNA CTD PMID:19691856 NCBI chr 9:82,866,159...82,981,668
Ensembl chr 9:82,866,159...82,975,516
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha increases expression ISO Clorgyline results in increased expression of PIK3C2A mRNA CTD PMID:19691856 NCBI chr 7:116,337,265...116,443,465
Ensembl chr 7:116,337,265...116,443,449
JBrowse link
G Polk polymerase (DNA directed), kappa increases expression ISO Clorgyline results in increased expression of POLK mRNA CTD PMID:19691856 NCBI chr13:96,480,687...96,542,579
Ensembl chr13:96,480,690...96,542,579
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions EXP [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein] CTD PMID:23499958 NCBI chr11:98,348,406...98,357,796
Ensembl chr11:98,348,404...98,357,796
JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 increases expression ISO Clorgyline results in increased expression of PREX2 mRNA CTD PMID:19691856 NCBI chr 1:10,993,273...11,303,683
Ensembl chr 1:10,993,465...11,303,681
JBrowse link
G Prodh2 proline dehydrogenase (oxidase) 2 increases expression ISO Clorgyline results in increased expression of PRODH2 mRNA CTD PMID:19691856 NCBI chr 7:30,493,586...30,513,402
Ensembl chr 7:30,493,622...30,513,402
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) increases expression ISO Clorgyline results in increased expression of PTPN22 mRNA CTD PMID:19691856 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Clorgyline results in increased expression of RAD50 mRNA CTD PMID:19691856 NCBI chr11:53,649,519...53,707,319
Ensembl chr11:53,649,519...53,707,319
JBrowse link
G Rad54b RAD54 homolog B (S. cerevisiae) increases expression ISO Clorgyline results in increased expression of RAD54B mRNA CTD PMID:19691856 NCBI chr 4:11,558,920...11,615,808
Ensembl chr 4:11,558,922...11,615,805
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 increases expression ISO Clorgyline results in increased expression of RAPGEF4 mRNA CTD PMID:19691856 NCBI chr 2:71,981,215...72,257,474
Ensembl chr 2:71,981,240...72,257,474
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 increases expression ISO Clorgyline results in increased expression of RB1CC1 mRNA CTD PMID:19691856 NCBI chr 1:6,214,634...6,276,375
Ensembl chr 1:6,206,197...6,276,648
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit increases expression ISO Clorgyline results in increased expression of REV3L mRNA CTD PMID:19691856 NCBI chr10:39,731,561...39,875,211
Ensembl chr10:39,732,118...39,875,211
JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression ISO Clorgyline results in increased expression of RGS5 mRNA CTD PMID:19691856 NCBI chr 1:169,655,501...169,695,813
Ensembl chr 1:169,655,501...169,695,813
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 increases expression ISO Clorgyline results in increased expression of RICTOR mRNA CTD PMID:19691856 NCBI chr15:6,708,349...6,800,401
Ensembl chr15:6,708,379...6,800,401
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Clorgyline results in increased expression of SCAF11 mRNA CTD PMID:19691856 NCBI chr15:96,411,698...96,460,988
Ensembl chr15:96,411,699...96,460,843
JBrowse link
G Selenop selenoprotein P increases expression ISO Clorgyline results in increased expression of SELENOP mRNA CTD PMID:19691856 NCBI chr15:3,270,767...3,280,510
Ensembl chr15:3,268,547...3,280,508
JBrowse link
G Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C increases expression ISO Clorgyline results in increased expression of SEMA3C mRNA CTD PMID:19691856 NCBI chr 5:17,574,816...17,730,268
Ensembl chr 5:17,574,281...17,730,268
JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 increases expression ISO Clorgyline results in increased expression of SENP6 mRNA CTD PMID:19691856 NCBI chr 9:80,066,575...80,144,782
Ensembl chr 9:80,066,903...80,144,953
JBrowse link
G Senp7 SUMO1/sentrin specific peptidase 7 increases expression ISO Clorgyline results in increased expression of SENP7 mRNA CTD PMID:19691856 NCBI chr16:56,057,526...56,190,031
Ensembl chr16:56,048,338...56,190,012
JBrowse link
G Shoc2 Shoc2, leucine rich repeat scaffold protein increases expression ISO Clorgyline results in increased expression of SHOC2 mRNA CTD PMID:19691856 NCBI chr19:53,944,232...54,033,280
Ensembl chr19:53,944,306...54,033,133
JBrowse link
G Slc4a5 solute carrier family 4, sodium bicarbonate cotransporter, member 5 increases expression ISO Clorgyline results in increased expression of SLC4A5 mRNA CTD PMID:19691856 NCBI chr 6:83,207,580...83,304,945
Ensembl chr 6:83,219,828...83,304,945
JBrowse link
G Slitrk6 SLIT and NTRK-like family, member 6 increases expression ISO Clorgyline results in increased expression of SLITRK6 mRNA CTD PMID:19691856 NCBI chr14:110,747,338...110,755,204
Ensembl chr14:110,748,580...110,755,149
JBrowse link
G Slk STE20-like kinase increases expression ISO Clorgyline results in increased expression of SLK mRNA CTD PMID:19691856 NCBI chr19:47,580,019...47,645,246
Ensembl chr19:47,579,678...47,645,246
JBrowse link
G Smchd1 SMC hinge domain containing 1 increases expression ISO Clorgyline results in increased expression of SMCHD1 mRNA CTD PMID:19691856 NCBI chr17:71,344,489...71,475,366
Ensembl chr17:71,344,489...71,475,343
JBrowse link
G Snord64 small nucleolar RNA, C/D box 64 increases expression ISO Clorgyline results in increased expression of SNORD64 mRNA CTD PMID:19691856 NCBI chr 7:59,978,811...59,978,856
Ensembl chr 7:59,978,808...59,978,874
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO Clorgyline results in increased expression of SOCS2 mRNA CTD PMID:19691856 NCBI chr10:95,383,903...95,417,321
Ensembl chr10:95,385,362...95,417,180
JBrowse link
G Stag2 stromal antigen 2 increases expression ISO Clorgyline results in increased expression of STAG2 mRNA CTD PMID:19691856 NCBI chr  X:42,149,297...42,277,186
Ensembl chr  X:42,149,317...42,277,185
JBrowse link
G Steap2 six transmembrane epithelial antigen of prostate 2 increases expression ISO Clorgyline results in increased expression of STEAP2 mRNA CTD PMID:19691856 NCBI chr 5:5,664,829...5,694,649
Ensembl chr 5:5,664,829...5,694,578
JBrowse link
G Stxbp4 syntaxin binding protein 4 increases expression ISO Clorgyline results in increased expression of STXBP4 mRNA CTD PMID:19691856 NCBI chr11:90,476,492...90,638,136
Ensembl chr11:90,476,492...90,638,084
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Clorgyline results in increased expression of TBC1D15 mRNA CTD PMID:19691856 NCBI chr10:115,197,871...115,251,493
Ensembl chr10:115,197,872...115,251,467
JBrowse link
G Tbc1d8b TBC1 domain family, member 8B increases expression ISO Clorgyline results in increased expression of TBC1D8B mRNA CTD PMID:19691856 NCBI chr  X:139,684,964...139,754,221
Ensembl chr  X:139,684,996...139,753,405
JBrowse link
G Tceal7 transcription elongation factor A (SII)-like 7 increases expression ISO Clorgyline results in increased expression of TCEAL7 mRNA CTD PMID:19691856 NCBI chr  X:136,224,041...136,226,100
Ensembl chr  X:136,214,779...136,226,100
JBrowse link
G Tex9 testis expressed gene 9 increases expression ISO Clorgyline results in increased expression of TEX9 mRNA CTD PMID:19691856 NCBI chr 9:72,458,055...72,510,945
Ensembl chr 9:72,450,394...72,492,212
JBrowse link
G Thap2 THAP domain containing, apoptosis associated protein 2 increases expression ISO Clorgyline results in increased expression of THAP2 mRNA CTD PMID:19691856 NCBI chr10:115,368,398...115,384,435
Ensembl chr10:115,368,404...115,384,443
JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 increases expression ISO Clorgyline results in increased expression of TMED5 mRNA CTD PMID:19691856 NCBI chr 5:108,121,556...108,132,620
Ensembl chr 5:108,106,366...108,132,620
JBrowse link
G Tmem106b transmembrane protein 106B increases expression ISO Clorgyline results in increased expression of TMEM106B mRNA CTD PMID:19691856 NCBI chr 6:13,069,759...13,089,269
Ensembl chr 6:13,069,759...13,089,269
JBrowse link
G Tmf1 TATA element modulatory factor 1 increases expression ISO Clorgyline results in increased expression of TMF1 mRNA CTD PMID:19691856 NCBI chr 6:97,151,950...97,179,151
Ensembl chr 6:97,152,997...97,179,122
JBrowse link
G Trip11 thyroid hormone receptor interactor 11 increases expression ISO Clorgyline results in increased expression of TRIP11 mRNA CTD PMID:19691856 NCBI chr12:101,834,045...101,913,171
Ensembl chr12:101,834,043...101,913,267
JBrowse link
G Tut7 terminal uridylyl transferase 7 increases expression ISO Clorgyline results in increased expression of TUT7 mRNA CTD PMID:19691856 NCBI chr13:59,771,876...59,823,169
Ensembl chr13:59,771,561...59,823,147
JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W (putative) increases expression ISO Clorgyline results in increased expression of UBE2W mRNA CTD PMID:19691856 NCBI chr 1:16,540,788...16,619,460
Ensembl chr 1:16,540,790...16,619,489
JBrowse link
G Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 increases expression ISO Clorgyline results in increased expression of UBLCP1 mRNA CTD PMID:19691856 NCBI chr11:44,454,571...44,470,713
Ensembl chr11:44,454,571...44,470,498
JBrowse link
G Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) increases expression ISO Clorgyline results in increased expression of UPF3B mRNA CTD PMID:19691856 NCBI chr  X:37,091,678...37,110,471
Ensembl chr  X:37,091,678...37,110,322
JBrowse link
G Utrn utrophin increases expression ISO Clorgyline results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr10:12,382,187...12,869,888
Ensembl chr10:12,382,188...12,869,365
JBrowse link
G Vcpip1 valosin containing protein (p97)/p47 complex interacting protein 1 increases expression ISO Clorgyline results in increased expression of VCPIP1 mRNA CTD PMID:19691856 NCBI chr 1:9,718,622...9,748,382
Ensembl chr 1:9,718,622...9,748,382
JBrowse link
G Vps13a vacuolar protein sorting 13A increases expression ISO Clorgyline results in increased expression of VPS13A mRNA CTD PMID:19691856 NCBI chr19:16,615,366...16,781,071
Ensembl chr19:16,615,366...16,780,933
JBrowse link
G Vps13c vacuolar protein sorting 13C increases expression ISO Clorgyline results in increased expression of VPS13C mRNA CTD PMID:19691856 NCBI chr 9:67,840,316...67,997,744
Ensembl chr 9:67,840,396...67,995,638
JBrowse link
G Vps37a vacuolar protein sorting 37A increases expression ISO Clorgyline results in increased expression of VPS37A mRNA CTD PMID:19691856 NCBI chr 8:40,511,742...40,551,134
Ensembl chr 8:40,511,783...40,550,757
JBrowse link
G Wdr17 WD repeat domain 17 increases expression ISO Clorgyline results in increased expression of WDR17 mRNA CTD PMID:19691856 NCBI chr 8:54,629,281...54,726,979
Ensembl chr 8:54,629,055...54,887,184
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 increases expression ISO Clorgyline results in increased expression of ZBTB1 mRNA CTD PMID:19691856 NCBI chr12:76,370,051...76,396,955
Ensembl chr12:76,370,266...76,396,950
JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 increases expression ISO Clorgyline results in increased expression of ZBTB10 mRNA CTD PMID:19691856 NCBI chr 3:9,250,567...9,285,333
Ensembl chr 3:9,250,602...9,285,333
JBrowse link
G Zfp280c zinc finger protein 280C increases expression ISO Clorgyline results in increased expression of ZNF280C mRNA CTD PMID:19691856 NCBI chr  X:48,541,626...48,594,648
Ensembl chr  X:48,541,625...48,594,504
JBrowse link
G Zfp280d zinc finger protein 280D increases expression ISO Clorgyline results in increased expression of ZNF280D mRNA CTD PMID:19691856 NCBI chr 9:72,274,618...72,363,779
Ensembl chr 9:72,274,860...72,363,777
JBrowse link
G Zfp292 zinc finger protein 292 increases expression ISO Clorgyline results in increased expression of ZNF292 mRNA CTD PMID:19691856 NCBI chr 4:34,803,110...34,882,983
Ensembl chr 4:34,803,113...34,882,960
JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO Clorgyline results in increased expression of ZNF449 mRNA CTD PMID:19691856 NCBI chr  X:56,346,397...56,365,674
Ensembl chr  X:56,346,400...56,365,674
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO Clorgyline results in increased expression of ZNF638 mRNA CTD PMID:19691856 NCBI chr 6:83,867,068...83,986,871
Ensembl chr 6:83,867,109...83,989,550
JBrowse link
G Zfp644 zinc finger protein 644 increases expression ISO Clorgyline results in increased expression of ZNF644 mRNA CTD PMID:19691856 NCBI chr 5:106,616,739...106,696,834
Ensembl chr 5:106,616,739...106,697,287
JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 increases expression ISO Clorgyline results in increased expression of ZFYVE16 mRNA CTD PMID:19691856 NCBI chr13:92,487,749...92,530,810
Ensembl chr13:92,487,108...92,530,868
JBrowse link
cyanophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [cyanophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
esomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA] CTD PMID:25929522 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein
CTD PMID:23112108, PMID:26095818 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein
CTD PMID:23112108, PMID:26095818 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
CTD PMID:23112108, PMID:26095818 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
decreases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein
CTD PMID:26687534 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A
CTD PMID:26095818 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein
CTD PMID:26687534 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability
ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein
CTD PMID:22037238 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmaline results in decreased activity of MAOA protein CTD PMID:15178694, PMID:24373881, PMID:28302559 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299, PMID:12107048 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression
ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA
CTD PMID:27590872 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity
ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein
CTD PMID:22037238 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein
CTD PMID:20732341 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions
decreases activity
ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein
CTD PMID:30189235 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions
decreases activity
ISO harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A2 protein
CTD PMID:30189235 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Taar1 trace amine-associated receptor 1 increases activity
multiple interactions
EXP harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr10:23,920,406...23,921,404
Ensembl chr10:23,920,356...23,921,469
JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Axin2 axin 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:108,917,828...108,950,783
Ensembl chr11:108,920,349...108,950,783
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 9:109,875,518...109,893,895
Ensembl chr 9:109,875,579...109,893,895
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation ISO Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 4:89,306,289...89,311,032
Ensembl chr 4:89,306,299...89,311,039
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 increases phosphorylation
multiple interactions
EXP Harmine results in increased phosphorylation of CHD4 protein
AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]
CTD PMID:27805061 NCBI chr 6:125,095,980...125,130,591
Ensembl chr 6:125,095,981...125,130,591
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions
increases expression
EXP Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein
CTD PMID:27805061 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785
JBrowse link
G Cox8b cytochrome c oxidase subunit 8B increases expression EXP Harmine results in increased expression of COX8B protein CTD PMID:27805061 NCBI chr 7:140,898,942...140,900,446
Ensembl chr 7:140,898,945...140,900,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein
CTD PMID:22001777 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases expression EXP Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a multiple interactions
affects binding
decreases activity
ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein
CTD PMID:21573099, PMID:25751815 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 4:136,172,274...136,196,057
Ensembl chr 4:136,172,394...136,196,057
JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr10:110,745,439...110,787,384
Ensembl chr10:110,745,439...110,787,384
JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 7:48,866,429...48,882,073
Ensembl chr 7:48,866,429...48,881,596
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140
JBrowse link
G Ins1 insulin I multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ins2 insulin II increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Lepr leptin receptor multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mafa v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr15:75,745,501...75,748,321
Ensembl chr15:75,745,490...75,748,228
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmine results in decreased activity of MAOA protein CTD PMID:24373881, PMID:28302559 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:80,606,205...80,713,071
Ensembl chr18:80,606,205...80,713,071
JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 2:168,476,410...168,601,657
Ensembl chr 2:168,476,410...168,601,657
JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr 8:106,058,818...106,130,537
Ensembl chr 8:106,058,840...106,130,537
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr14:55,824,795...55,833,943
Ensembl chr14:55,823,144...55,833,943
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr 5:147,270,097...147,275,848
Ensembl chr 5:147,269,959...147,275,848
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression
EXP [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein
CTD PMID:20519739, PMID:27805061 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
EXP Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]
Harmine results in increased expression of PPARGC1A protein
CTD PMID:27805061 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prdm16 PR domain containing 16 increases expression
multiple interactions
EXP Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]
CTD PMID:27805061 NCBI chr 4:154,316,122...154,637,360
Ensembl chr 4:154,316,125...154,636,873
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]
Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
CTD PMID:27805061 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:59,248,036...59,290,751
Ensembl chr11:59,248,033...59,290,752
JBrowse link
isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases reduction ISO AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the reduction of Isatin CTD PMID:18845131 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) affects reduction
increases reduction
EXP
ISO
Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin
CTD PMID:10510318, PMID:12604212 NCBI chr 4:139,310,720...139,318,786
Ensembl chr 4:139,310,744...139,318,426
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin] CTD PMID:23295225 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of Isatin CTD PMID:19061875 NCBI chr16:93,683,219...93,690,991
Ensembl chr16:93,683,215...93,690,990
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases expression ISO Isatin results in increased expression of CYP2A6 mRNA CTD PMID:15056799 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases expression ISO Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Isatin results in increased expression of CYP2E1 mRNA CTD PMID:15056799 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Dhrs11 dehydrogenase/reductase (SDR family) member 11 increases reduction ISO DHRS11 protein results in increased reduction of Isatin CTD PMID:30926317 NCBI chr11:84,820,721...84,829,067
Ensembl chr11:84,820,856...84,828,994
JBrowse link
G Dhrs7 dehydrogenase/reductase (SDR family) member 7 increases reduction ISO DHRS7 protein results in increased reduction of Isatin CTD PMID:24246760 NCBI chr12:72,650,353...72,664,828
Ensembl chr12:72,650,353...72,664,909
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10] CTD PMID:24316276 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO] CTD PMID:24316276 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2] CTD PMID:24316276 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF] CTD PMID:24316276 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
licocoumarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a multiple interactions ISO licocoumarone binds to and results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517
JBrowse link
G Met met proto-oncogene decreases expression ISO licocoumarone results in decreased expression of MET protein CTD PMID:31838052 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr 1:172,271,709...172,298,064
Ensembl chr 1:172,271,709...172,298,064
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity ISO Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Glrx glutaredoxin multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr13:75,839,885...75,850,151
Ensembl chr13:75,839,868...75,850,154
JBrowse link
G Glrx2 glutaredoxin 2 (thioltransferase) multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr 1:143,739,224...143,749,678
Ensembl chr 1:143,716,338...143,749,676
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr14:67,745,181...67,749,440
Ensembl chr14:67,745,181...67,749,439
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215, PMID:25943564 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:16,709,281...16,817,366
Ensembl chr  X:16,709,282...16,817,366
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453, PMID:24556215 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564, PMID:31428839 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215, PMID:31428839 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215, PMID:31428839 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr 1:161,240,112...161,251,210
Ensembl chr 1:161,240,112...161,251,219
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions
increases activity
EXP oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
monocrotophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 increases expression ISO Monocrotophos results in increased expression of ABCA1 mRNA CTD PMID:32267039 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases expression
increases activity
ISO Monocrotophos results in increased expression of ACACA mRNA
Monocrotophos results in increased activity of ACACA protein
CTD PMID:32267039 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases expression
decreases activity
ISO
EXP
asoxime chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]
Monocrotophos results in decreased expression of ACHE mRNA
[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein
CTD PMID:8783813, PMID:15679473, PMID:15793557, PMID:20026515, PMID:20728503, PMID:21349312, PMID:22285544, PMID:22903060 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Monocrotophos results in decreased expression of ADIPOQ protein CTD PMID:32267039 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Ahr aryl-hydrocarbon receptor affects expression
increases expression
multiple interactions
ISO Monocrotophos affects the expression of AHR protein
Monocrotophos results in increased expression of AHR mRNA
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein
CTD PMID:22733800 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions
increases expression
ISO Monocrotophos results in increased expression of and affects the localization of APEX1 protein
Monocrotophos results in increased expression of APEX1 mRNA
CTD PMID:28887667 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO Monocrotophos results in increased expression of and affects the localization of BAX protein; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]
Monocrotophos results in increased expression of BAX mRNA; Monocrotophos results in increased expression of BAX protein
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO Monocrotophos results in increased expression of BBC3 mRNA CTD PMID:20957986 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
multiple interactions
decreases expression
ISO Monocrotophos results in increased expression of BCL2 mRNA; Monocrotophos results in increased expression of BCL2 protein
resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein]
Monocrotophos results in decreased expression of BCL2 mRNA; Monocrotophos results in decreased expression of BCL2 protein
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l2 BCL2-like 2 decreases expression ISO Monocrotophos results in decreased expression of BCL2L2 mRNA; Monocrotophos results in decreased expression of BCL2L2 protein CTD PMID:20957986, PMID:21445290 NCBI chr14:54,883,366...54,890,858
Ensembl chr14:54,892,500...54,898,169
Ensembl chr14:54,892,500...54,898,169
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO Monocrotophos results in increased expression of CASP3 mRNA; Monocrotophos results in increased expression of CASP3 protein; Monocrotophos results in increased expression of CASP3 protein modified form
Resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 mRNA]; Resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 protein]
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 increases expression ISO Monocrotophos results in increased expression of CASP9 mRNA; Monocrotophos results in increased expression of CASP9 protein; Monocrotophos results in increased expression of CASP9 protein modified form CTD PMID:20957986, PMID:21445290 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase decreases activity ISO Monocrotophos results in decreased activity of CAT protein CTD PMID:22751200 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Monocrotophos results in increased expression of CDKN1A mRNA; Monocrotophos results in increased expression of CDKN1A protein CTD PMID:20957986, PMID:21445290 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Monocrotophos results in increased expression of and affects the localization of CYCS protein CTD PMID:20957986 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO Monocrotophos results in increased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein
Monocrotophos results in increased expression of CYP1A1 mRNA; Monocrotophos results in increased expression of CYP1A1 protein
Monocrotophos results in increased activity of CYP1A1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Monocrotophos results in increased expression of CYP1A2 protein CTD PMID:21445290 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases activity
increases expression
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein
Monocrotophos results in increased activity of CYP2B6 protein
Monocrotophos results in increased expression of CYP2B6 mRNA; Monocrotophos results in increased expression of CYP2B6 protein
CTD PMID:22733800 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Monocrotophos results in increased expression of CYP2B2 protein CTD PMID:21445290 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions
increases activity
ISO Monocrotophos results in increased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein
Monocrotophos results in increased expression of CYP2E1 mRNA; Monocrotophos results in increased expression of CYP2E1 protein
Monocrotophos results in increased activity of CYP2E1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases expression
increases activity
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein
Monocrotophos results in increased expression of CYP3A4 mRNA; Monocrotophos results in increased expression of CYP3A4 protein
Monocrotophos results in increased activity of CYP3A4 protein
CTD PMID:22733800 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases expression ISO Monocrotophos results in increased expression of CYP7A1 mRNA CTD PMID:32267039 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Fasn fatty acid synthase increases activity
increases expression
ISO Monocrotophos results in increased activity of FASN protein
Monocrotophos results in increased expression of FASN mRNA
CTD PMID:32267039 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Monocrotophos results in increased expression of FOS protein CTD PMID:20957986, PMID:21445290 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked affects activity
increases activity
multiple interactions
ISO Monocrotophos affects the activity of G6PD protein
Monocrotophos results in increased activity of G6PD protein
[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein
CTD PMID:24248738, PMID:32267039 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gck glucokinase increases activity ISO Monocrotophos results in increased activity of GCK protein CTD PMID:32267039 NCBI chr11:5,900,816...5,950,081
Ensembl chr11:5,900,820...5,950,081
JBrowse link
G Gsr glutathione reductase decreases activity
multiple interactions
affects activity
ISO Monocrotophos results in decreased activity of GSR protein
[Monocrotophos co-treated with quinalphos] affects the activity of GSR protein
Monocrotophos affects the activity of GSR protein
CTD PMID:22751200, PMID:24248738 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
increases expression
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein
Monocrotophos results in increased expression of GSTP1 mRNA; Monocrotophos results in increased expression of GSTP1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression ISO Monocrotophos results in increased expression of HMGCR mRNA CTD PMID:32267039 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Il2 interleukin 2 decreases response to substance EXP Monocrotophos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Jun jun proto-oncogene increases expression
multiple interactions
ISO Monocrotophos results in increased expression of JUN protein
Monocrotophos results in increased expression of and results in increased phosphorylation of JUN protein
CTD PMID:20957986, PMID:21445290, PMID:28887667 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Monocrotophos results in increased expression of LDLR mRNA CTD PMID:32267039 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lig3 ligase III, DNA, ATP-dependent increases expression ISO Monocrotophos results in increased expression of LIG3 mRNA CTD PMID:28887667 NCBI chr11:82,781,109...82,804,274
Ensembl chr11:82,781,108...82,804,274
JBrowse link
G Lpin1 lipin 1 increases activity ISO Monocrotophos results in increased activity of LPIN1 protein CTD PMID:32267039 NCBI chr12:16,535,669...16,653,903
Ensembl chr12:16,535,669...16,646,966
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Monocrotophos results in increased expression of LPL mRNA CTD PMID:32267039 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Monocrotophos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Monocrotophos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:16,709,281...16,817,366
Ensembl chr  X:16,709,282...16,817,366
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO Monocrotophos results in decreased expression of MCL1 mRNA; Monocrotophos results in decreased expression of MCL1 protein CTD PMID:20957986, PMID:21445290 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO Monocrotophos results in increased expression of NFE2L2 protein CTD PMID:28887667 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression
multiple interactions
ISO Monocrotophos affects the expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein
CTD PMID:22733800 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
decreases expression
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
Monocrotophos results in increased expression of NR1I3 mRNA; Monocrotophos results in increased expression of NR1I3 protein
Monocrotophos results in decreased expression of NR1I3 protein
CTD PMID:22733800 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression ISO Monocrotophos results in decreased expression of OGG1 mRNA CTD PMID:28887667 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO Monocrotophos results in increased expression of PARP1 mRNA; Monocrotophos results in increased expression of PARP1 protein CTD PMID:28887667 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Monocrotophos results in decreased expression of PPARA mRNA CTD PMID:32267039 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO Monocrotophos results in increased expression of PPARG mRNA CTD PMID:32267039 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Monocrotophos results in increased expression of SCARB1 mRNA CTD PMID:32267039 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Monocrotophos results in increased expression of SREBF1 mRNA CTD PMID:32267039 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 increases expression ISO Monocrotophos results in increased expression of SREBF2 mRNA CTD PMID:32267039 NCBI chr15:82,147,269...82,205,379
Ensembl chr15:82,147,181...82,205,379
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity
ISO Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Monocrotophos results in increased expression of TNF protein CTD PMID:32267039 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Monocrotophos results in increased expression of TP53 mRNA; Monocrotophos results in increased expression of TP53 protein; Monocrotophos results in increased expression of TRP53 mRNA; Monocrotophos results in increased expression of TRP53 protein CTD PMID:20957986, PMID:21445290 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 increases expression ISO Omeprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity ISO Omeprazole results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects expression
multiple interactions
ISO Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]
CTD PMID:19483382, PMID:30452898 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 decreases expression ISO Omeprazole results in decreased expression of ABCB4 mRNA CTD PMID:12040753 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO Omeprazole results in increased expression of ABCC3 mRNA CTD PMID:19118567 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 affects expression ISO Omeprazole affects the expression of ABCC6 mRNA CTD PMID:19483382 NCBI chr 7:45,974,110...46,030,491
Ensembl chr 7:45,967,555...46,030,302
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression
multiple interactions
ISO Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]
CTD PMID:20804740, PMID:31348918 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression ISO Omeprazole affects the expression of ABCG5 mRNA CTD PMID:19483382 NCBI chr17:84,658,174...84,683,011
Ensembl chr17:84,658,234...84,683,011
JBrowse link
G Abhd1 abhydrolase domain containing 1 affects expression ISO Omeprazole affects the expression of ABHD1 mRNA CTD PMID:19483382 NCBI chr 5:30,950,066...30,955,095
Ensembl chr 5:30,950,066...30,955,091
JBrowse link
G Abhd14b abhydrolase domain containing 14b affects expression ISO Omeprazole affects the expression of ABHD14B mRNA CTD PMID:19483382 NCBI chr 9:106,447,737...106,452,923
Ensembl chr 9:106,447,459...106,452,923
JBrowse link
G Abhd17a abhydrolase domain containing 17A affects expression ISO Omeprazole affects the expression of ABHD17A mRNA CTD PMID:19483382 NCBI chr10:80,583,649...80,590,341
Ensembl chr10:80,583,654...80,590,341
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha affects expression ISO Omeprazole affects the expression of ACACA mRNA CTD PMID:19483382 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain affects expression ISO Omeprazole affects the expression of ACADL mRNA CTD PMID:19483382 NCBI chr 1:66,830,839...66,863,309
Ensembl chr 1:66,830,839...66,863,277
JBrowse link
G Aco1 aconitase 1 affects expression ISO Omeprazole affects the expression of ACO1 mRNA CTD PMID:19483382 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Aco2 aconitase 2, mitochondrial affects expression ISO Omeprazole affects the expression of ACO2 mRNA CTD PMID:19483382 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Acot12 acyl-CoA thioesterase 12 affects expression ISO Omeprazole affects the expression of ACOT12 mRNA CTD PMID:19483382 NCBI chr13:91,741,326...91,786,148
Ensembl chr13:91,741,512...91,786,148
JBrowse link
G Acot4 acyl-CoA thioesterase 4 affects expression ISO Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 NCBI chr12:84,037,254...84,044,723
Ensembl chr12:84,038,379...84,048,601
JBrowse link
G Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) affects expression ISO Omeprazole affects the expression of ADAM15 mRNA CTD PMID:19483382 NCBI chr 3:89,339,640...89,350,028
Ensembl chr 3:89,338,542...89,349,996
JBrowse link
G Add1 adducin 1 (alpha) affects expression ISO Omeprazole affects the expression of ADD1 mRNA CTD PMID:19483382 NCBI chr 5:34,573,664...34,632,308
Ensembl chr 5:34,573,664...34,632,308
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression ISO Omeprazole results in decreased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 3:138,277,585...138,290,698
Ensembl chr 3:138,260,991...138,290,698
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide affects expression ISO Omeprazole affects the expression of ADH4 mRNA CTD PMID:19483382 NCBI chr 3:138,415,456...138,432,683
Ensembl chr 3:138,415,466...138,430,892
JBrowse link
G Adtrp androgen dependent TFPI regulating protein affects expression ISO Omeprazole affects the expression of ADTRP mRNA CTD PMID:19483382 NCBI chr13:41,763,145...41,847,616
Ensembl chr13:41,763,148...41,847,684
JBrowse link
G Afm afamin affects expression ISO Omeprazole affects the expression of AFM mRNA CTD PMID:19483382 NCBI chr 5:90,518,949...90,553,544
Ensembl chr 5:90,518,932...90,553,543
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) affects expression ISO Omeprazole affects the expression of AGT mRNA CTD PMID:19483382 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects expression ISO Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
decreases activity
increases activity
increases expression
decreases expression
affects localization
increases response to substance
ISO
EXP
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
Omeprazole results in decreased activity of AHR protein
Omeprazole affects the localization of AHR protein
AHR protein results in increased susceptibility to Omeprazole
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9139728, PMID:9395520, PMID:14742684, PMID:16109480, PMID:20171196, PMID:21703235, PMID:21861773, PMID:21924250, PMID:22687989, PMID:23850985, PMID:25797602, PMID:25826687, PMID:26187274, PMID:26272953, PMID:31669099 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) affects expression ISO Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 NCBI chr 4:116,636,510...116,651,674
Ensembl chr 4:116,636,510...116,651,680
JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) affects expression ISO Omeprazole affects the expression of AKR7A2 mRNA CTD PMID:19483382 NCBI chr 4:139,310,720...139,318,786
Ensembl chr 4:139,310,744...139,318,426
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects expression
multiple interactions
ISO Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA
CTD PMID:19483382, PMID:22687989 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 increases expression ISO Omeprazole results in increased expression of ALDH1A3 mRNA CTD PMID:12040753 NCBI chr 7:66,390,892...66,427,477
Ensembl chr 7:66,390,890...66,427,517
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial affects expression ISO Omeprazole affects the expression of ALDH2 mRNA CTD PMID:19483382 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 increases expression ISO Omeprazole results in increased expression of ALDH3A1 mRNA CTD PMID:12040753 NCBI chr11:61,208,510...61,218,418
Ensembl chr11:61,207,537...61,218,421
JBrowse link
G Alkbh7 alkB homolog 7 affects expression ISO Omeprazole affects the expression of ALKBH7 mRNA CTD PMID:19483382 NCBI chr17:56,997,339...56,999,340
Ensembl chr17:56,997,339...56,999,322
JBrowse link
G Ap2m1 adaptor-related protein complex 2, mu 1 subunit affects expression ISO Omeprazole affects the expression of AP2M1 mRNA CTD PMID:19483382 NCBI chr16:20,535,480...20,544,909
Ensembl chr16:20,535,478...20,544,909
JBrowse link
G Apcs serum amyloid P-component affects expression ISO Omeprazole affects the expression of APCS mRNA CTD PMID:19483382 NCBI chr 1:172,893,961...172,895,054
Ensembl chr 1:172,893,961...172,895,041
JBrowse link
G Apoa4 apolipoprotein A-IV affects expression ISO Omeprazole affects the expression of APOA4 mRNA CTD PMID:19483382 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Apoh apolipoprotein H affects expression ISO Omeprazole affects the expression of APOH mRNA CTD PMID:19483382 NCBI chr11:108,395,297...108,414,396
Ensembl chr11:108,343,354...108,414,396
JBrowse link
G Apool apolipoprotein O-like affects expression ISO Omeprazole affects the expression of APOOL mRNA CTD PMID:19483382 NCBI chr  X:112,311,352...112,372,755
Ensembl chr  X:112,311,334...112,372,755
JBrowse link
G Arg1 arginase, liver affects expression ISO Omeprazole affects the expression of ARG1 mRNA CTD PMID:19483382 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484
JBrowse link
G Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 affects expression ISO Omeprazole affects the expression of ARL6IP1 mRNA CTD PMID:19483382 NCBI chr 7:118,118,890...118,129,625
Ensembl chr 7:118,118,891...118,129,662
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
affects localization
ISO Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9395520, PMID:21703235, PMID:25826687 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Asgr2 asialoglycoprotein receptor 2 affects expression ISO Omeprazole affects the expression of ASGR2 mRNA CTD PMID:19483382 NCBI chr11:70,092,644...70,106,187
Ensembl chr11:70,092,644...70,106,187
JBrowse link
G Atf5 activating transcription factor 5 affects expression ISO Omeprazole affects the expression of ATF5 mRNA CTD PMID:19483382 NCBI chr 7:44,812,256...44,816,658
Ensembl chr 7:44,812,256...44,816,658
JBrowse link
G Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit affects expression ISO Omeprazole affects the expression of ATP5F1E mRNA CTD PMID:19483382 NCBI chr 2:174,461,075...174,464,101
Ensembl chr 2:174,461,072...174,464,105
JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 affects expression ISO Omeprazole affects the expression of ATP6AP2 mRNA CTD PMID:19483382 NCBI chr  X:12,587,759...12,617,051
Ensembl chr  X:12,587,801...12,617,049
JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A affects expression ISO Omeprazole affects the expression of ATP6V1A mRNA CTD PMID:19483382 NCBI chr16:44,085,402...44,139,702
Ensembl chr16:44,085,402...44,139,705
JBrowse link
G Atp6v1f ATPase, H+ transporting, lysosomal V1 subunit F affects expression ISO Omeprazole affects the expression of ATP6V1F mRNA CTD PMID:19483382 NCBI chr 6:29,467,783...29,470,509
Ensembl chr 6:29,467,718...29,470,512
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions ISO
EXP
Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
CTD PMID:25337692 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Baat bile acid-Coenzyme A: amino acid N-acyltransferase affects expression ISO Omeprazole affects the expression of BAAT mRNA CTD PMID:19483382 NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:30452898 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:30452898 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B affects expression ISO Omeprazole affects the expression of BCL6B mRNA CTD PMID:19483382 NCBI chr11:70,224,127...70,229,798
Ensembl chr11:70,224,128...70,229,798
JBrowse link
G Bmf BCL2 modifying factor affects expression ISO Omeprazole affects the expression of BMF mRNA CTD PMID:19483382 NCBI chr 2:118,528,757...118,549,686
Ensembl chr 2:118,528,757...118,549,687
JBrowse link
G Bmx BMX non-receptor tyrosine kinase multiple interactions ISO BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein] CTD PMID:21861773 NCBI chr  X:164,192,842...164,258,193
Ensembl chr  X:164,192,842...164,258,193
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 affects expression ISO Omeprazole affects the expression of BNIP3 mRNA CTD PMID:19483382 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Btf3 basic transcription factor 3 affects expression ISO Omeprazole affects the expression of BTF3 mRNA CTD PMID:19483382 NCBI chr13:98,309,897...98,317,006
Ensembl chr13:98,309,896...98,317,006
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression ISO Omeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C1qbp complement component 1, q subcomponent binding protein affects expression ISO Omeprazole affects the expression of C1QBP mRNA CTD PMID:19483382 NCBI chr11:70,977,846...70,983,026
Ensembl chr11:70,977,836...70,983,026
JBrowse link
G C1qc complement component 1, q subcomponent, C chain decreases expression ISO Omeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 4:136,889,801...136,892,936
Ensembl chr 4:136,889,804...136,893,065
JBrowse link
G C1s2 complement component 1, s subcomponent 2 affects expression ISO Omeprazole affects the expression of C1S mRNA CTD PMID:19483382 NCBI chr 6:124,624,625...124,636,085
Ensembl chr 6:124,624,625...124,636,085
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 affects expression ISO Omeprazole affects the expression of C2CD2 mRNA CTD PMID:19483382 NCBI chr16:97,855,209...97,925,795
Ensembl chr16:97,855,209...97,962,598
JBrowse link
G C7 complement component 7 affects expression ISO Omeprazole affects the expression of C7 mRNA CTD PMID:19483382 NCBI chr15:4,987,750...5,063,773
Ensembl chr15:4,988,762...5,063,740
JBrowse link
G C8b complement component 8, beta polypeptide affects expression ISO Omeprazole affects the expression of C8B mRNA CTD PMID:19483382 NCBI chr 4:104,766,317...104,804,548
Ensembl chr 4:104,766,317...104,804,548
JBrowse link
G Cadps2 Ca2+-dependent activator protein for secretion 2 affects expression ISO Omeprazole affects the expression of CADPS2 mRNA CTD PMID:19483382 NCBI chr 6:23,262,773...23,841,175
Ensembl chr 6:23,262,773...23,839,421
JBrowse link
G Caprin1 cell cycle associated protein 1 affects expression ISO Omeprazole affects the expression of CAPRIN1 mRNA CTD PMID:19483382 NCBI chr 2:103,762,945...103,797,669
Ensembl chr 2:103,762,941...103,797,649
JBrowse link
G Car2 carbonic anhydrase 2 affects expression ISO Omeprazole affects the expression of CA2 mRNA CTD PMID:19483382 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Car3 carbonic anhydrase 3 affects expression ISO Omeprazole affects the expression of CAR3 mRNA CTD PMID:19483382 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
affects expression
increases cleavage
ISO Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein
CTD PMID:15461867, PMID:18336733, PMID:19251492, PMID:19483382, PMID:25637687, PMID:30452898 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Cat catalase increases activity ISO Omeprazole results in increased activity of CAT protein CTD PMID:18547560 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Omeprazole affects the expression of CBR1 mRNA CTD PMID:19483382 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Cckbr cholecystokinin B receptor multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr 7:105,425,676...105,436,339
Ensembl chr 7:105,425,731...105,470,898
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Omeprazole results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Omeprazole results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdo1 cysteine dioxygenase 1, cytosolic affects expression ISO Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 NCBI chr18:46,713,193...46,728,502
Ensembl chr18:46,713,193...46,728,395
JBrowse link
G Cept1 choline/ethanolaminephosphotransferase 1 affects expression ISO Omeprazole affects the expression of CEPT1 mRNA CTD PMID:19483382 NCBI chr 3:106,502,260...106,547,802
Ensembl chr 3:106,502,260...106,547,802
JBrowse link
G Ces2h carboxylesterase 2H affects expression ISO Omeprazole affects the expression of CES2 mRNA CTD PMID:19483382 NCBI chr 8:105,000,830...105,020,410
Ensembl chr 8:105,000,853...105,021,178
JBrowse link
G Cfi complement component factor i affects expression
decreases expression
ISO Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA
CTD PMID:19483382, PMID:25626140 NCBI chr 3:129,836,727...129,875,332
Ensembl chr 3:129,835,884...129,875,332
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator affects metabolic processing EXP CFTR protein affects the metabolism of Omeprazole CTD PMID:15319328 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chp1 calcineurin-like EF hand protein 1 affects expression ISO Omeprazole affects the expression of CHP1 mRNA CTD PMID:19483382 NCBI chr 2:119,547,707...119,587,024
Ensembl chr 2:119,547,697...119,587,027
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 affects expression ISO Omeprazole affects the expression of CISD1 mRNA CTD PMID:19483382 NCBI chr10:71,330,494...71,344,849
Ensembl chr10:71,330,480...71,344,954
JBrowse link
G Clcn4 chloride channel, voltage-sensitive 4 affects expression ISO Omeprazole affects the expression of CLCN4 mRNA CTD PMID:19483382 NCBI chr 7:7,282,309...7,300,916
Ensembl chr 7:7,282,309...7,300,851
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects expression ISO Omeprazole affects the expression of CLPP mRNA CTD PMID:19483382 NCBI chr17:56,990,264...56,996,371
Ensembl chr17:56,990,305...56,996,188
JBrowse link
G Clptm1l CLPTM1-like affects expression ISO Omeprazole affects the expression of CLPTM1L mRNA CTD PMID:19483382 NCBI chr13:73,604,002...73,620,639
Ensembl chr13:73,604,006...73,620,605
JBrowse link
G Cmbl carboxymethylenebutenolidase-like (Pseudomonas) affects expression ISO Omeprazole affects the expression of CMBL mRNA CTD PMID:19483382 NCBI chr15:31,565,342...31,590,119
Ensembl chr15:31,565,389...31,590,119
JBrowse link
G Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 affects expression ISO Omeprazole affects the expression of CMPK1 mRNA CTD PMID:19483382 NCBI chr 4:114,960,613...114,987,228
Ensembl chr 4:114,959,336...114,987,241
JBrowse link
G Copg1 coatomer protein complex, subunit gamma 1 affects expression ISO Omeprazole affects the expression of COPG1 mRNA CTD PMID:19483382 NCBI chr 6:87,887,819...87,913,595
Ensembl chr 6:87,887,814...87,913,595
JBrowse link
G Cops4 COP9 signalosome subunit 4 affects expression ISO Omeprazole affects the expression of COPS4 mRNA CTD PMID:19483382 NCBI chr 5:100,518,295...100,547,802
Ensembl chr 5:100,518,309...100,547,803
JBrowse link
G Coq3 coenzyme Q3 methyltransferase affects expression ISO Omeprazole affects the expression of COQ3 mRNA CTD PMID:19483382 NCBI chr 4:21,879,646...21,912,163
Ensembl chr 4:21,879,673...21,912,162
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 affects expression ISO Omeprazole affects the expression of COX4I1 mRNA CTD PMID:19483382 NCBI chr 8:120,668,225...120,674,209
Ensembl chr 8:120,668,222...120,674,207
JBrowse link
G Cpn1 carboxypeptidase N, polypeptide 1 affects expression ISO Omeprazole affects the expression of CPN1 mRNA CTD PMID:19483382 NCBI chr19:43,956,307...43,986,551
Ensembl chr19:43,956,307...43,986,556
JBrowse link
G Cpq carboxypeptidase Q affects expression ISO Omeprazole affects the expression of CPQ mRNA CTD PMID:19483382 NCBI chr15:33,083,129...33,594,552
Ensembl chr15:33,083,129...33,594,552
JBrowse link
G Crem cAMP responsive element modulator affects expression ISO Omeprazole affects the expression of CREM mRNA CTD PMID:19483382 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Csnk2b casein kinase 2, beta polypeptide affects expression ISO Omeprazole affects the expression of CSNK2B mRNA CTD PMID:19483382 NCBI chr17:35,116,195...35,122,053
Ensembl chr17:35,116,196...35,122,053
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects expression ISO Omeprazole affects the expression of CSRP1 mRNA CTD PMID:19483382 NCBI chr 1:135,720,063...135,752,229
Ensembl chr 1:135,720,061...135,752,232
JBrowse link
G Ctnna1 catenin (cadherin associated protein), alpha 1 affects expression ISO Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 NCBI chr18:35,118,902...35,254,776
Ensembl chr18:35,118,859...35,254,779
JBrowse link
G Ctsd cathepsin D multiple interactions ISO Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctse cathepsin E decreases expression ISO Omeprazole results in decreased expression of CTSE CTD PMID:7575556 NCBI chr 1:131,638,314...131,675,507
Ensembl chr 1:131,638,306...131,675,505
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 decreases expression
multiple interactions
ISO Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]
CTD PMID:25826687 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases activity
increases expression
ISO
EXP
Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
CTD PMID:8647108, PMID:8900397, PMID:9041675, PMID:9139728, PMID:9152597, PMID:9395520, PMID:9860486, PMID:10103034, PMID:10859152, PMID:11454723, PMID:11849738, PMID:12040753, PMID:12623754, PMID:12841937, PMID:14742684, PMID:14987951, PMID:15681896, PMID:15860653, PMID:17202759, PMID:17954527, PMID:18420780, PMID:18502397, PMID:19118567, PMID:20171196, PMID:21666223, PMID:21703235, PMID:21784029, PMID:22687989, PMID:25626140, PMID:25826687, PMID:26272953 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
decreases activity
multiple interactions
ISO
EXP
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:9152597, PMID:9744552, PMID:12040753, PMID:12623754, PMID:12841937, PMID:15681896, PMID:15802389, PMID:16035375, PMID:17954527, PMID:18332078, PMID:18420780, PMID:18502397, PMID:19118567, PMID:19230594, PMID:20171196, PMID:21784029, PMID:21924250, PMID:22524704, PMID:22687989, PMID:23274770, PMID:23850985, PMID:24752503, PMID:25626140, PMID:26204831, PMID:27794450, PMID:31863871 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
affects expression
decreases activity
increases expression
ISO
EXP
Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole results in increased expression of CYP1B1 mRNA
CTD PMID:12040753, PMID:12623754, PMID:18420780, PMID:21703235, PMID:25826687 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 affects expression ISO Omeprazole affects the expression of CYP2A1 mRNA CTD PMID:19483382 NCBI chr 7:26,931,631...26,939,413
Ensembl chr 7:26,931,631...26,939,384
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
increases activity
decreases activity
ISO
EXP
Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein
Omeprazole results in decreased activity of CYP2B10 protein
CTD PMID:9152597, PMID:17954527, PMID:18420780, PMID:19118567, PMID:22524704 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression
affects expression
ISO Omeprazole results in increased expression of CYP2B2 protein
Omeprazole affects the expression of CYP2B2 mRNA
CTD PMID:9152597, PMID:19483382 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 affects expression ISO Omeprazole affects the expression of CYP2B3 mRNA CTD PMID:19483382 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661
JBrowse link
G Cyp2c37 cytochrome P450, family 2. subfamily c, polypeptide 37 multiple interactions
increases metabolic processing
EXP [CYP2C37 protein results in increased metabolism of Omeprazole] which results in increased chemical synthesis of 5-hydroxymethylomeprazole CTD PMID:30503582 NCBI chr19:39,992,424...40,012,243
Ensembl chr19:39,992,424...40,012,243
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects metabolic processing
multiple interactions
decreases activity
increases metabolic processing
increases hydroxylation
decreases metabolic processing
ISO CYP2C19 protein affects the metabolism of Omeprazole
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 protein results in increased hydroxylation of Omeprazole
CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
CTD PMID:8930576, PMID:9600717, PMID:11752104, PMID:12464242, PMID:12467917, PMID:12485723, PMID:12637241, PMID:14586384, PMID:15258107, PMID:15286053, PMID:15306208, PMID:15626586, PMID:16035375, PMID:17565714, PMID:17702393, PMID:18511451, PMID:18520598, PMID:19812348, PMID:20573087, PMID:21277363, PMID:21795468, PMID:21915887, PMID:22634058, PMID:26599973, PMID:31515991 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac] CTD PMID:15258107 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
decreases activity
ISO
EXP
Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
Omeprazole results in decreased activity of CYP2C9 protein
CTD PMID:15258107, PMID:18420780 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects expression
decreases activity
ISO
EXP
Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein
CTD PMID:18420780, PMID:19483382 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:15802389 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 affects expression ISO Omeprazole affects the expression of CYP2F4 mRNA CTD PMID:19483382 NCBI chr 7:27,119,955...27,133,660
Ensembl chr 7:27,119,909...27,133,660
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 affects expression ISO Omeprazole affects the expression of CYP2J4 mRNA CTD PMID:19483382 NCBI chr 4:96,568,424...96,592,523
Ensembl chr 4:96,568,429...96,591,578
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity
increases metabolic processing
affects metabolic processing
increases expression
multiple interactions
EXP
ISO
Omeprazole results in decreased activity of CYP3A11 protein; Omeprazole results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Omeprazole
CYP3A4 protein affects the metabolism of Omeprazole
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:7870052, PMID:8930576, PMID:9744552, PMID:12235278, PMID:12485723, PMID:12695340, PMID:15286053, PMID:15466163, PMID:15626586, PMID:15802389, PMID:17041008, PMID:17565714, PMID:17954527, PMID:18420780, PMID:19118567, PMID:19299527, PMID:22634058 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects expression
increases expression
ISO Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA
CTD PMID:19118567, PMID:19483382 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Dbi diazepam binding inhibitor affects expression ISO Omeprazole affects the expression of DBI mRNA CTD PMID:19483382 NCBI chr 1:120,113,280...120,121,096
Ensembl chr 1:120,113,280...120,121,078
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 affects expression ISO Omeprazole affects the expression of DCAF11 mRNA CTD PMID:19483382 NCBI chr14:55,559,125...55,570,065
Ensembl chr14:55,560,006...55,570,065
JBrowse link
G Dcxr dicarbonyl L-xylulose reductase affects expression ISO Omeprazole affects the expression of DCXR mRNA CTD PMID:19483382 NCBI chr11:120,724,546...120,727,284
Ensembl chr11:120,725,399...120,727,281
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Omeprazole results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial affects expression ISO Omeprazole affects the expression of DECR1 mRNA CTD PMID:19483382 NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
JBrowse link
G Dexi dexamethasone-induced transcript affects expression ISO Omeprazole affects the expression of DEXI mRNA CTD PMID:19483382 NCBI chr16:10,530,207...10,543,054
Ensembl chr16:10,502,531...10,543,054
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 affects expression ISO Omeprazole affects the expression of DGAT1 mRNA CTD PMID:19483382 NCBI chr15:76,502,012...76,512,021
Ensembl chr15:76,502,015...76,511,953
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Omeprazole affects the expression of DHCR24 mRNA CTD PMID:19483382 NCBI chr 4:106,561,038...106,589,113
Ensembl chr 4:106,561,038...106,589,113
JBrowse link
G Dhrs4 dehydrogenase/reductase (SDR family) member 4 affects expression ISO Omeprazole affects the expression of DHRS4 mRNA CTD PMID:19483382 NCBI chr14:55,478,741...55,490,340
Ensembl chr14:55,478,758...55,490,340
JBrowse link
G Dhrs7b dehydrogenase/reductase (SDR family) member 7B affects expression ISO Omeprazole affects the expression of DHRS7B mRNA CTD PMID:19483382 NCBI chr11:60,830,631...60,858,423
Ensembl chr11:60,830,631...60,860,195
JBrowse link
G Dhx16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 affects expression ISO Omeprazole affects the expression of DHX16 mRNA CTD PMID:19483382 NCBI chr17:35,879,764...35,892,670
Ensembl chr17:35,879,819...35,892,670
JBrowse link
G Dmac2l distal membrane arm assembly complex 2 like affects expression ISO Omeprazole affects the expression of DMAC2L mRNA CTD PMID:19483382 NCBI chr12:69,724,913...69,744,665
Ensembl chr12:69,724,950...69,744,660
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 affects expression ISO Omeprazole affects the expression of DNAJC3 mRNA CTD PMID:19483382 NCBI chr14:118,937,932...118,981,702
Ensembl chr14:118,937,976...118,981,697
JBrowse link
G Dpp4 dipeptidylpeptidase 4 affects expression ISO Omeprazole affects the expression of DPP4 mRNA CTD PMID:19483382 NCBI chr 2:62,330,073...62,412,315
Ensembl chr 2:62,330,073...62,412,231
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression ISO Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 NCBI chr 3:118,562,109...119,432,924
Ensembl chr 3:118,562,129...119,432,924
JBrowse link
G Ears2 glutamyl-tRNA synthetase 2, mitochondrial affects expression ISO Omeprazole affects the expression of EARS2 mRNA CTD PMID:19483382 NCBI chr 7:122,034,162...122,067,094
Ensembl chr 7:122,037,213...122,067,263
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial affects expression ISO Omeprazole affects the expression of ECHS1 mRNA CTD PMID:19483382 NCBI chr 7:140,105,710...140,116,421
Ensembl chr 7:140,105,710...140,116,476
JBrowse link
G Eci1 enoyl-Coenzyme A delta isomerase 1 affects expression ISO Omeprazole affects the expression of ECI1 mRNA CTD PMID:19483382 NCBI chr17:24,426,683...24,439,316
Ensembl chr17:24,426,641...24,439,348
JBrowse link
G Eci2 enoyl-Coenzyme A delta isomerase 2 affects expression ISO Omeprazole affects the expression of ECI2 mRNA CTD PMID:19483382 NCBI chr13:34,977,748...35,027,115
Ensembl chr13:34,977,748...35,027,096
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma affects expression ISO Omeprazole affects the expression of EEF1G mRNA CTD PMID:19483382 NCBI chr19:8,967,041...8,978,180
Ensembl chr19:8,967,041...8,978,479
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase affects expression ISO Omeprazole affects the expression of EHHADH mRNA CTD PMID:19483382 NCBI chr16:21,761,285...21,787,834
Ensembl chr16:21,761,287...21,787,807
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression ISO Omeprazole affects the expression of EIF4A2 mRNA CTD PMID:19483382 NCBI chr16:23,107,468...23,114,132
Ensembl chr16:23,107,444...23,114,136
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 affects expression ISO Omeprazole affects the expression of EIF4EBP1 mRNA CTD PMID:19483382 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H affects expression ISO Omeprazole affects the expression of EIF4H mRNA CTD PMID:19483382 NCBI chr 5:134,619,872...134,639,409
Ensembl chr 5:134,619,721...134,639,490
JBrowse link
G Enc1 ectodermal-neural cortex 1 affects expression ISO Omeprazole affects the expression of ENC1 mRNA CTD PMID:19483382 NCBI chr13:97,241,105...97,253,040
Ensembl chr13:97,241,105...97,253,034
JBrowse link
G Eno1 enolase 1, alpha non-neuron affects expression ISO Omeprazole affects the expression of ENO1 mRNA CTD PMID:19483382 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Enpep glutamyl aminopeptidase affects expression ISO Omeprazole affects the expression of ENPEP mRNA CTD PMID:19483382 NCBI chr 3:129,269,177...129,332,749
Ensembl chr 3:129,269,175...129,332,720
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Omeprazole affects the expression of ENPP1 mRNA CTD PMID:19483382 NCBI chr10:24,637,914...24,712,159
Ensembl chr10:24,637,914...24,712,159
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Epcam epithelial cell adhesion molecule affects expression ISO Omeprazole affects the expression of EPCAM mRNA CTD PMID:19483382 NCBI chr17:87,635,979...87,651,127
Ensembl chr17:87,635,979...87,651,129
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression ISO Omeprazole affects the expression of ERP29 mRNA CTD PMID:19483382 NCBI chr 5:121,444,753...121,452,474
Ensembl chr 5:121,428,590...121,452,506
JBrowse link
G Esd esterase D/formylglutathione hydrolase affects expression ISO Omeprazole affects the expression of ESD mRNA CTD PMID:19483382 NCBI chr14:74,732,151...74,750,765
Ensembl chr14:74,732,297...74,750,765
JBrowse link
G Etfb electron transferring flavoprotein, beta polypeptide affects expression ISO Omeprazole affects the expression of ETFB mRNA CTD PMID:19483382 NCBI chr 7:43,444,072...43,457,800
Ensembl chr 7:43,444,083...43,457,800
JBrowse link
G Faah fatty acid amide hydrolase affects expression ISO Omeprazole affects the expression of FAAH mRNA CTD PMID:19483382 NCBI chr 4:115,996,668...116,018,837
Ensembl chr 4:115,967,145...116,017,926
JBrowse link
G Fads2 fatty acid desaturase 2 affects expression ISO Omeprazole affects the expression of FADS2 mRNA CTD PMID:19483382 NCBI chr19:10,062,765...10,101,503
Ensembl chr19:10,062,765...10,101,746
JBrowse link
G Fbp1 fructose bisphosphatase 1 affects expression ISO Omeprazole affects the expression of FBP1 mRNA CTD PMID:19483382 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects expression ISO Omeprazole affects the expression of FDFT1 mRNA CTD PMID:19483382 NCBI chr14:63,145,150...63,181,687
Ensembl chr14:63,145,150...63,179,578
JBrowse link
G Fdps farnesyl diphosphate synthetase affects expression ISO Omeprazole affects the expression of FDPS mRNA CTD PMID:19483382 NCBI chr 3:89,093,588...89,101,967
Ensembl chr 3:89,093,588...89,101,959
JBrowse link
G Fdx2 ferredoxin 2 affects expression ISO Omeprazole affects the expression of FDX2 mRNA CTD PMID:19483382 NCBI chr 9:21,067,512...21,073,531
Ensembl chr 9:21,067,520...21,073,614
JBrowse link
G Fmo1 flavin containing monooxygenase 1 affects expression ISO Omeprazole affects the expression of FMO1 mRNA CTD PMID:19483382 NCBI chr 1:162,829,561...162,866,610
Ensembl chr 1:162,829,561...162,866,610
JBrowse link
G Gamt guanidinoacetate methyltransferase affects expression ISO Omeprazole affects the expression of GAMT mRNA CTD PMID:19483382 NCBI chr10:80,258,151...80,261,025
Ensembl chr10:80,258,151...80,261,012
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression ISO Omeprazole affects the expression of GAPDH mRNA CTD PMID:19483382 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gast gastrin increases expression EXP
ISO
Omeprazole results in increased expression of GAST protein CTD PMID:11422300, PMID:12189558, PMID:12763636, PMID:15223672, PMID:16618411, PMID:17652263 NCBI chr11:100,334,407...100,336,997
Ensembl chr11:100,334,407...100,336,996
JBrowse link
G Gbe1 glucan (1,4-alpha-), branching enzyme 1 affects expression ISO Omeprazole affects the expression of GBE1 mRNA CTD PMID:19483382 NCBI chr16:70,313,949...70,569,720
Ensembl chr16:70,313,949...70,569,716
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator affects expression ISO Omeprazole affects the expression of GCHFR mRNA CTD PMID:19483382 NCBI chr 2:119,167,788...119,172,389
Ensembl chr 2:119,167,773...119,172,390
JBrowse link
G Ggh gamma-glutamyl hydrolase affects expression ISO Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 NCBI chr 4:20,041,997...20,066,111
Ensembl chr 4:20,042,052...20,066,750
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA CTD PMID:22687989 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Gjb1 gap junction protein, beta 1 affects expression ISO Omeprazole affects the expression of GJB1 mRNA CTD PMID:19483382 NCBI chr  X:101,376,376...101,385,629
Ensembl chr  X:101,376,378...101,385,629
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Omeprazole affects the expression of GPLD1 mRNA CTD PMID:19483382 NCBI chr13:24,937,785...24,991,936
Ensembl chr13:24,943,152...24,992,501
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression ISO Omeprazole affects the expression of GPX1 mRNA CTD PMID:19483382 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:22687989 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression ISO Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) affects expression ISO Omeprazole affects the expression of GRINA mRNA CTD PMID:19483382 NCBI chr15:76,246,717...76,249,909
Ensembl chr15:76,246,764...76,249,904
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial affects expression ISO Omeprazole affects the expression of GRPEL1 mRNA CTD PMID:19483382 NCBI chr 5:36,465,185...36,474,077
Ensembl chr 5:36,464,998...36,474,080
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions
increases expression
ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
Omeprazole results in increased expression of GSTA5 mRNA
CTD PMID:17202759, PMID:22687989 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO Omeprazole results in increased expression of GSTP1 mRNA CTD PMID:19118567 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 affects expression ISO Omeprazole affects the expression of GSTT1 mRNA CTD PMID:19483382 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G Gtf2h5 general transcription factor IIH, polypeptide 5 affects expression ISO Omeprazole affects the expression of GTF2H5 mRNA CTD PMID:19483382 NCBI chr17:6,079,828...6,085,488
Ensembl chr17:6,079,786...6,086,517
JBrowse link
G Gzma granzyme A affects expression ISO Omeprazole affects the expression of GZMA mRNA CTD PMID:19483382 NCBI chr13:113,093,824...113,100,981
Ensembl chr13:113,093,825...113,100,981
JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa affects expression ISO Omeprazole affects the expression of HLA-DMA mRNA CTD PMID:25811541 NCBI chr17:34,119,693...34,139,101
Ensembl chr17:34,119,541...34,139,101
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 affects expression ISO Omeprazole affects the expression of HLA-B mRNA CTD PMID:25811541 NCBI chr17:37,480,851...37,483,554
Ensembl chr17:37,480,851...37,483,552
JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression ISO Omeprazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,270,234...37,274,485
Ensembl chr17:37,270,220...37,274,484
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Omeprazole affects the expression of RT1-S3 mRNA CTD PMID:19483382 NCBI chr17:36,029,977...36,032,701
Ensembl chr17:36,029,773...36,032,855
JBrowse link
G H3f3b H3.3 histone B affects expression ISO Omeprazole affects the expression of H3F3B mRNA CTD PMID:19483382 NCBI chr11:116,021,961...116,026,039
Ensembl chr11:116,021,912...116,027,962
JBrowse link
G Hal histidine ammonia lyase affects expression ISO Omeprazole affects the expression of HAL mRNA CTD PMID:19483382 NCBI chr10:93,488,768...93,516,761
Ensembl chr10:93,488,768...93,519,304
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
increases secretion
EXP
ISO
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased secretion of HAMP protein
CTD PMID:31669099 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Hao2 hydroxyacid oxidase 2 affects expression ISO Omeprazole affects the expression of HAO2 mRNA CTD PMID:19483382 NCBI chr 3:98,874,519...98,895,376
Ensembl chr 3:98,874,521...98,893,239
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects expression ISO Omeprazole affects the expression of HBA-A2 mRNA CTD PMID:19483382 NCBI chr11:32,296,492...32,297,310
Ensembl chr11:32,296,489...32,297,298
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain affects expression ISO Omeprazole affects the expression of HBB mRNA CTD PMID:19483382
G Hdc histidine decarboxylase affects expression
increases stability
increases expression
multiple interactions
ISO Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein
CTD PMID:12763636, PMID:19483382 NCBI chr 2:126,593,659...126,624,025
Ensembl chr 2:126,593,667...126,619,299
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase affects expression ISO Omeprazole affects the expression of HGD mRNA CTD PMID:19483382 NCBI chr16:37,579,742...37,632,026
Ensembl chr16:37,580,153...37,632,020
JBrowse link
G Hmgn1 high mobility group nucleosomal binding domain 1 affects expression ISO Omeprazole affects the expression of HMGN1 mRNA CTD PMID:19483382 NCBI chr16:96,121,588...96,127,725
Ensembl chr16:96,120,618...96,127,729
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
CTD PMID:16712795, PMID:27725188 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hprt hypoxanthine guanine phosphoribosyl transferase affects expression ISO Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 NCBI chr  X:52,988,078...53,021,660
Ensembl chr  X:52,988,137...53,021,659
JBrowse link
G Hps5 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 affects expression ISO Omeprazole affects the expression of HPS5 mRNA CTD PMID:19483382 NCBI chr 7:46,760,466...46,796,065
Ensembl chr 7:46,760,466...46,796,064
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects expression ISO Omeprazole affects the expression of HSD17B4 mRNA CTD PMID:19483382 NCBI chr18:50,128,201...50,196,270
Ensembl chr18:50,128,201...50,196,269
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 affects expression ISO Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 NCBI chr 4:59,581,517...59,618,694
Ensembl chr 4:59,581,563...59,618,689
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions
decreases expression
ISO Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
CTD PMID:15223672, PMID:16945336 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa1l heat shock protein 1-like multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr17:34,972,703...34,979,228
Ensembl chr17:34,972,703...34,979,285
JBrowse link
G Htra1 HtrA serine peptidase 1 affects expression ISO Omeprazole affects the expression of HTRA1 mRNA CTD PMID:19483382 NCBI chr 7:130,936,203...130,985,658
Ensembl chr 7:130,936,111...130,985,660
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr17:35,821,713...35,822,911
Ensembl chr17:35,821,684...35,822,923
JBrowse link
G Ifng interferon gamma multiple interactions ISO Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:19232345 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO Omeprazole affects the expression of IGF1 mRNA CTD PMID:19483382 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit affects expression ISO Omeprazole affects the expression of IGFALS mRNA CTD PMID:19483382 NCBI chr17:24,877,844...24,882,011
Ensembl chr17:24,865,997...24,882,010
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression ISO Omeprazole affects the expression of IGFBP2 mRNA CTD PMID:19483382 NCBI chr 1:72,824,480...72,852,474
Ensembl chr 1:72,824,503...72,852,474
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein] CTD PMID:25637687 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Impa1 inositol (myo)-1(or 4)-monophosphatase 1 affects expression ISO Omeprazole affects the expression of IMPA1 mRNA CTD PMID:19483382 NCBI chr 3:10,311,956...10,331,439
Ensembl chr 3:10,311,956...10,331,439
JBrowse link
G Inhbe inhibin beta-E affects expression ISO Omeprazole affects the expression of INHBE mRNA CTD PMID:19483382 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411
JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 affects expression ISO Omeprazole affects the expression of ISYNA1 mRNA CTD PMID:19483382 NCBI chr 8:70,594,481...70,597,290
Ensembl chr 8:70,594,373...70,597,290
JBrowse link
G Itih4 inter alpha-trypsin inhibitor, heavy chain 4 affects expression ISO Omeprazole affects the expression of ITIH4 mRNA CTD PMID:19483382 NCBI chr14:30,886,476...30,901,986
Ensembl chr14:30,886,476...30,902,353
JBrowse link
G Jak1 Janus kinase 1 affects expression ISO Omeprazole affects the expression of JAK1 mRNA CTD PMID:19483382 NCBI chr 4:101,151,974...101,265,282
Ensembl chr 4:101,152,367...101,265,282
JBrowse link
G Kdelr2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 affects expression ISO Omeprazole affects the expression of KDELR2 mRNA CTD PMID:19483382 NCBI chr 5:143,403,820...143,421,904
Ensembl chr 5:143,403,838...143,421,901
JBrowse link
G Kdr kinase insert domain protein receptor affects expression
multiple interactions
ISO
EXP
Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]
CTD PMID:19483382, PMID:26272953 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Krt8 keratin 8 affects expression ISO Omeprazole affects the expression of KRT8 mRNA CTD PMID:19483382 NCBI chr15:101,996,711...102,004,342
Ensembl chr15:101,996,698...102,004,482
JBrowse link
G Lcat lecithin cholesterol acyltransferase affects expression ISO Omeprazole affects the expression of LCAT mRNA CTD PMID:19483382 NCBI chr 8:105,939,551...105,943,402
Ensembl chr 8:105,939,551...105,943,382
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 affects expression ISO Omeprazole affects the expression of LCMT1 mRNA CTD PMID:19483382 NCBI chr 7:123,377,803...123,430,358
Ensembl chr 7:123,369,784...123,430,358
JBrowse link
G Lipc lipase, hepatic affects expression ISO Omeprazole affects the expression of LIPC mRNA CTD PMID:19483382 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lox lysyl oxidase affects expression ISO Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 NCBI chr18:52,516,060...52,529,867
Ensembl chr18:52,516,067...52,529,867
JBrowse link
G Lrp3 low density lipoprotein receptor-related protein 3 affects expression ISO Omeprazole affects the expression of LRP3 mRNA CTD PMID:19483382 NCBI chr 7:35,200,878...35,217,392
Ensembl chr 7:35,200,027...35,215,498
JBrowse link
G Man2b1 mannosidase 2, alpha B1 affects expression ISO Omeprazole affects the expression of MAN2B1 mRNA CTD PMID:19483382 NCBI chr 8:85,082,730...85,098,739
Ensembl chr 8:85,083,270...85,098,282
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 affects expression ISO Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:17406807 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Masp2 mannan-binding lectin serine peptidase 2 affects expression ISO Omeprazole affects the expression of MASP2 mRNA CTD PMID:19483382 NCBI chr 4:148,594,622...148,615,499
Ensembl chr 4:148,602,554...148,615,499
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic affects expression
multiple interactions
ISO Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA
CTD PMID:19483382, PMID:22687989 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions ISO Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein] CTD PMID:16934674 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmut methylmalonyl-Coenzyme A mutase affects expression ISO Omeprazole affects the expression of MMUT mRNA CTD PMID:19483382 NCBI chr17:40,934,685...40,961,990
Ensembl chr17:40,934,685...40,961,988
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD PMID:16091555, PMID:17151854, PMID:20165931, PMID:25637687, PMID:27780710, PMID:29770154, PMID:31095933 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mro maestro affects expression ISO Omeprazole affects the expression of MRO mRNA CTD PMID:19483382 NCBI chr18:73,851,826...73,881,334
Ensembl chr18:73,859,385...73,881,333
JBrowse link
G Mrpl2 mitochondrial ribosomal protein L2 affects expression ISO Omeprazole affects the expression of MRPL2 mRNA CTD PMID:19483382 NCBI chr17:46,646,172...46,650,132
Ensembl chr17:46,646,229...46,650,139
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 affects expression ISO Omeprazole affects the expression of MRPL9 mRNA CTD PMID:19483382 NCBI chr 3:94,443,154...94,448,708
Ensembl chr 3:94,443,318...94,451,130
JBrowse link
G Mug1 murinoglobulin 1 affects expression ISO Omeprazole affects the expression of PZP mRNA CTD PMID:19483382 NCBI chr 6:121,838,496...121,889,057
Ensembl chr 6:121,838,541...121,889,057
JBrowse link
G Myadm myeloid-associated differentiation marker affects expression ISO Omeprazole affects the expression of MYADM mRNA CTD PMID:19483382 NCBI chr 7:3,289,038...3,299,355
Ensembl chr 7:3,289,080...3,300,442
JBrowse link
G Mycbp2 MYC binding protein 2, E3 ubiquitin protein ligase affects expression ISO Omeprazole affects the expression of MYCBP2 mRNA CTD PMID:19483382 NCBI chr14:103,113,411...103,346,840
Ensembl chr14:103,113,411...103,346,814
JBrowse link
G Myo1d myosin ID affects expression ISO Omeprazole affects the expression of MYO1D mRNA CTD PMID:19483382 NCBI chr11:80,482,126...80,780,055
Ensembl chr11:80,482,126...80,780,025
JBrowse link
G Naa38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit affects expression ISO Omeprazole affects the expression of NAA38 mRNA CTD PMID:19483382 NCBI chr11:69,395,791...69,396,671
Ensembl chr11:69,395,487...69,396,680
JBrowse link
G Nap1l1