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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.4.3.4 (monoamine oxidase) inhibitor
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Accession:CHEBI:38623 term browser browse the term
Definition:An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
Synonyms:related_synonym: EC 1.4.3.4 (monoamine oxidase) inhibitors;   EC 1.4.3.4 inhibitor;   EC 1.4.3.4 inhibitors;   MAO A inhibitor;   MAO A inhibitors;   MAO B inhibitors;   MAO inhibitor;   MAO inhibitors;   MAO-B inhibitor;   adrenalin oxidase inhibitor;   adrenalin oxidase inhibitors;   adrenaline oxidase inhibitor;   adrenaline oxidase inhibitors;   amine oxidase (flavin-containing) inhibitor;   amine oxidase (flavin-containing) inhibitors;   amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor;   amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors;   amine:oxygen oxidoreductase (deaminating) inhibitor;   amine:oxygen oxidoreductase (deaminating) inhibitors;   epinephrine oxidase inhibitor;   epinephrine oxidase inhibitors;   monoamine oxidase A inhibitor;   monoamine oxidase A inhibitors;   monoamine oxidase B inhibitor;   monoamine oxidase B inhibitors;   monoamine oxidase inhibitor;   monoamine oxidase inhibitors;   monoamine:O2 oxidoreductase (deaminating) inhibitor;   monoamine:O2 oxidoreductase (deaminating) inhibitors;   serotonin deaminase inhibitor;   serotonin deaminase inhibitors;   tyraminase inhibitor;   tyraminase inhibitors;   tyramine oxidase inhibitor;   tyramine oxidase inhibitors
 xref: Wikipedia:Monoamine_oxidase_inhibitor


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5'-hydroxyomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO 5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein CTD PMID:10103034 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor multiple interactions
increases response to substance
ISO 8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060, PMID:15641640, PMID:18608257, PMID:19966059, PMID:21195062 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G DRD2 dopamine receptor D2 affects response to substance
multiple interactions
ISO DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368, PMID:10199625 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NTS neurotensin multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992
JBrowse link
aminoguanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme multiple interactions ISO pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein] CTD PMID:12161173 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein] CTD PMID:26723916, PMID:29148590 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G ALB albumin multiple interactions EXP
ISO
pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]
CTD PMID:12196478, PMID:22287321 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G AOC1 amine oxidase copper containing 1 multiple interactions
decreases activity
EXP
ISO
pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]
pimagedine results in decreased activity of AOC1 protein
CTD PMID:6218830, PMID:8144586 NCBI chr 7:150,824,875...150,861,504
Ensembl chr 7:150,824,627...150,861,504
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO pimagedine results in decreased expression of ATP2B1 mRNA CTD PMID:15003327 NCBI chr12:89,588,049...89,709,366
Ensembl chr12:89,588,049...89,709,300
JBrowse link
G BACE1 beta-secretase 1 multiple interactions EXP pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA] CTD PMID:28242320 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP pimagedine results in decreased expression of BAX protein CTD PMID:19266598 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein
CTD PMID:16980304, PMID:17135264, PMID:17786558 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:14729435 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP3 caspase 3 multiple interactions ISO pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein] CTD PMID:15545282 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions ISO
EXP
pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]
CTD PMID:17786558, PMID:19556603 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases expression
ISO
EXP
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein
CTD PMID:12123627, PMID:19107871, PMID:19266598, PMID:19481068, PMID:22287321 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 decreases expression EXP pimagedine results in decreased expression of CAV1 protein CTD PMID:19706615 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,525,001...116,561,184
JBrowse link
G CD34 CD34 molecule decreases expression EXP pimagedine results in decreased expression of CD34 protein CTD PMID:19266598 NCBI chr 1:207,880,972...207,911,125
Ensembl chr 1:207,880,972...207,911,402
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein] CTD PMID:19061877 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression ISO pimagedine results in increased expression of COL1A1 mRNA CTD PMID:18380797 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation ISO pimagedine results in decreased phosphorylation of CREB1 protein CTD PMID:17135264 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 multiple interactions ISO [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein CTD PMID:17138957 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] CTD PMID:18594475 NCBI chr16:88,643,289...88,651,079
Ensembl chr16:88,643,289...88,651,054
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA] CTD PMID:9853001 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] CTD PMID:18594475 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G FCER2 Fc fragment of IgE receptor II multiple interactions EXP pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein] CTD PMID:11500085 NCBI chr19:7,688,759...7,702,755
Ensembl chr19:7,688,758...7,702,146
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein] CTD PMID:10462538 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA] CTD PMID:12763045 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO [7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein] CTD PMID:20826152 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GLO1 glyoxalase I multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:26723916, PMID:28919305, PMID:29148590 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA] CTD PMID:12763045 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein] CTD PMID:25406100 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein] CTD PMID:29148590 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions ISO
EXP
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
CTD PMID:7689037, PMID:11498278, PMID:12612912, PMID:12892526, PMID:12911628, PMID:28242320 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]
CTD PMID:11500085, PMID:12123627, PMID:25406100, PMID:28223158, PMID:28919305 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]
CTD PMID:25042521, PMID:26723916, PMID:28223158, PMID:29148590 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LPA lipoprotein(a) multiple interactions EXP pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]; pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein] CTD PMID:10856522 NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,483...160,664,259
Ensembl chr 6:160,531,483...160,664,259
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:12473873 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:12473873 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression EXP pimagedine results in decreased expression of MKI67 mRNA CTD PMID:19266598 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression ISO pimagedine results in increased expression of MMP13 mRNA CTD PMID:18380797 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP14 matrix metallopeptidase 14 increases expression ISO pimagedine results in increased expression of MMP14 mRNA CTD PMID:18380797 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA] CTD PMID:18594475 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11713966, PMID:18209962 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects activity
affects expression
ISO pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA
CTD PMID:17936468 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G NOS1 nitric oxide synthase 1 affects expression ISO pimagedine affects the expression of NOS1 mRNA CTD PMID:22777123 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
affects expression
decreases expression
decreases activity
ISO
EXP
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
CTD PMID:9306416, PMID:9810145, PMID:9853001, PMID:11574821, PMID:12054156, PMID:12473873, PMID:12892526, PMID:14550746, PMID:14729435, PMID:15821589, PMID:17135264, PMID:17138957, PMID:17637181, PMID:17936468, PMID:18594475, PMID:19266598, PMID:19481068, PMID:20455021, PMID:20463352, PMID:21397503, PMID:22777123, PMID:22961095, PMID:25406100, PMID:28223158, PMID:29935243 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 affects expression
multiple interactions
ISO pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]
CTD PMID:18483403 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein] CTD PMID:12763045 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions EXP pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] CTD PMID:10856522 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO [Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD PMID:26723916, PMID:28919305 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PSEN1 presenilin 1 multiple interactions EXP pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA] CTD PMID:28242320 NCBI chr14:73,136,436...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PSEN2 presenilin 2 multiple interactions EXP pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA] CTD PMID:28242320 NCBI chr 1:226,870,594...226,903,829
Ensembl chr 1:226,870,184...226,896,105
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein CTD PMID:15067210, PMID:17637181, PMID:29935243 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein] CTD PMID:29935243 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G S100B S100 calcium binding protein B multiple interactions ISO pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein] CTD PMID:19494442 NCBI chr21:46,598,604...46,605,243
Ensembl chr21:46,598,604...46,605,208
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions
increases expression
EXP
ISO
pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA
CTD PMID:10856522, PMID:18380797 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP pimagedine results in decreased expression of SOD1 protein CTD PMID:19266598 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases expression
ISO
EXP
pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein
CTD PMID:18483403, PMID:19266598 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein] CTD PMID:19061877 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
ISO pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]
CTD PMID:18380797, PMID:25406100 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression ISO pimagedine results in increased expression of TIMP1 mRNA CTD PMID:18380797 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:12123627, PMID:12612912, PMID:22287321, PMID:25042521, PMID:25406100, PMID:26723916, PMID:28223158 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions ISO TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]] CTD PMID:14550746 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA] CTD PMID:12763045 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid] CTD PMID:17880178 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions EXP [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BACE1 beta-secretase 1 decreases activity EXP Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
clorgyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 increases expression EXP Clorgyline results in increased expression of ABCA5 mRNA CTD PMID:19691856 NCBI chr17:69,244,311...69,327,133
Ensembl chr17:69,244,311...69,327,244
JBrowse link
G ACADSB acyl-CoA dehydrogenase short/branched chain increases expression EXP Clorgyline results in increased expression of ACADSB mRNA CTD PMID:19691856 NCBI chr10:123,009,006...123,058,290
Ensembl chr10:123,008,979...123,058,290
Ensembl chr10:123,008,979...123,058,290
JBrowse link
G ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression EXP Clorgyline results in increased expression of ACAP2 mRNA CTD PMID:19691856 NCBI chr 3:195,274,742...195,443,176
Ensembl chr 3:195,274,745...195,443,044
JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression EXP Clorgyline results in increased expression of ADRB2 mRNA CTD PMID:19691856 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G AKAP11 A-kinase anchoring protein 11 increases expression EXP Clorgyline results in increased expression of AKAP11 mRNA CTD PMID:19691856 NCBI chr13:42,271,470...42,323,266
Ensembl chr13:42,272,152...42,323,261
JBrowse link
G AKAP9 A-kinase anchoring protein 9 increases expression EXP Clorgyline results in increased expression of AKAP9 mRNA CTD PMID:19691856 NCBI chr 7:91,940,862...92,112,908
Ensembl chr 7:91,940,867...92,110,673
Ensembl chr 7:91,940,867...92,110,673
JBrowse link
G ANKRD12 ankyrin repeat domain 12 increases expression EXP Clorgyline results in increased expression of ANKRD12 mRNA CTD PMID:19691856 NCBI chr18:9,136,767...9,285,985
Ensembl chr18:9,136,228...9,285,985
JBrowse link
G APC APC regulator of WNT signaling pathway increases expression EXP Clorgyline results in increased expression of APC mRNA CTD PMID:19691856 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G AR androgen receptor increases expression EXP Clorgyline results in increased expression of AR mRNA CTD PMID:19691856 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 increases expression EXP Clorgyline results in increased expression of ARAP2 mRNA CTD PMID:19691856 NCBI chr 4:36,005,186...36,244,833
Ensembl chr 4:35,948,221...36,244,514
JBrowse link
G ARID4A AT-rich interaction domain 4A increases expression EXP Clorgyline results in increased expression of ARID4A mRNA CTD PMID:19691856 NCBI chr14:58,298,385...58,373,876
Ensembl chr14:58,298,504...58,373,887
JBrowse link
G ATG4C autophagy related 4C cysteine peptidase increases expression EXP Clorgyline results in increased expression of ATG4C mRNA CTD PMID:19691856 NCBI chr 1:62,783,765...62,865,516
Ensembl chr 1:62,784,132...62,865,516
JBrowse link
G ATRX ATRX chromatin remodeler increases expression EXP Clorgyline results in increased expression of ATRX mRNA CTD PMID:19691856 NCBI chr  X:77,504,880...77,786,235
Ensembl chr  X:77,504,880...77,786,233
Ensembl chr  X:77,504,880...77,786,233
JBrowse link
G AZI2 5-azacytidine induced 2 increases expression EXP Clorgyline results in increased expression of AZI2 mRNA CTD PMID:19691856 NCBI chr 3:28,321,047...28,349,278
Ensembl chr 3:28,315,003...28,349,050
JBrowse link
G B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 increases expression EXP Clorgyline results in increased expression of B3GNT5 mRNA CTD PMID:19691856 NCBI chr 3:183,253,207...183,273,391
Ensembl chr 3:183,253,253...183,298,504
JBrowse link
G BAZ2B bromodomain adjacent to zinc finger domain 2B increases expression EXP Clorgyline results in increased expression of BAZ2B mRNA CTD PMID:19691856 NCBI chr 2:159,315,312...159,712,442
Ensembl chr 2:159,318,979...159,616,569
Ensembl chr 2:159,318,979...159,616,569
JBrowse link
G BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression EXP Clorgyline results in increased expression of BDP1 mRNA CTD PMID:19691856 NCBI chr 5:71,455,636...71,578,288
Ensembl chr 5:71,455,651...71,567,820
JBrowse link
G BOD1L1 biorientation of chromosomes in cell division 1 like 1 increases expression EXP Clorgyline results in increased expression of BOD1L1 mRNA CTD PMID:19691856 NCBI chr 4:13,568,738...13,627,725
Ensembl chr 4:13,568,738...13,627,725
JBrowse link
G BRWD1 bromodomain and WD repeat domain containing 1 increases expression EXP Clorgyline results in increased expression of BRWD1 mRNA CTD PMID:19691856 NCBI chr21:39,184,176...39,321,595
Ensembl chr21:39,184,176...39,321,559
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 increases expression EXP Clorgyline results in increased expression of CACNB2 mRNA CTD PMID:19691856 NCBI chr10:18,140,424...18,545,881
Ensembl chr10:18,140,677...18,543,557
Ensembl chr10:18,140,677...18,543,557
JBrowse link
G CBLN2 cerebellin 2 precursor increases expression EXP Clorgyline results in increased expression of CBLN2 mRNA CTD PMID:19691856 NCBI chr18:72,533,720...72,638,485
Ensembl chr18:72,536,680...72,638,521
JBrowse link
G CCDC112 coiled-coil domain containing 112 increases expression EXP Clorgyline results in increased expression of CCDC112 mRNA CTD PMID:19691856 NCBI chr 5:115,267,190...115,296,755
Ensembl chr 5:115,267,190...115,296,693
JBrowse link
G CDH23 cadherin related 23 increases expression EXP Clorgyline results in increased expression of CDH23 mRNA CTD PMID:19691856 NCBI chr10:71,396,920...71,815,947
Ensembl chr10:71,396,920...71,815,947
JBrowse link
G CENPC centromere protein C increases expression EXP Clorgyline results in increased expression of CENPC mRNA CTD PMID:19691856 NCBI chr 4:67,468,762...67,545,503
Ensembl chr 4:67,468,762...67,545,503
JBrowse link
G CEP135 centrosomal protein 135 increases expression EXP Clorgyline results in increased expression of CEP135 mRNA CTD PMID:19691856 NCBI chr 4:55,948,808...56,033,361
Ensembl chr 4:55,948,871...56,033,361
JBrowse link
G CEP290 centrosomal protein 290 increases expression EXP Clorgyline results in increased expression of CEP290 mRNA CTD PMID:19691856 NCBI chr12:88,049,013...88,142,216
Ensembl chr12:88,049,016...88,142,099
Ensembl chr12:88,049,016...88,142,099
JBrowse link
G CEP350 centrosomal protein 350 increases expression EXP Clorgyline results in increased expression of CEP350 mRNA CTD PMID:19691856 NCBI chr 1:179,954,773...180,114,875
Ensembl chr 1:179,954,773...180,114,875
JBrowse link
G CEP70 centrosomal protein 70 increases expression EXP Clorgyline results in increased expression of CEP70 mRNA CTD PMID:19691856 NCBI chr 3:138,494,339...138,594,318
Ensembl chr 3:138,494,344...138,594,538
JBrowse link
G CFH complement factor H increases expression EXP Clorgyline results in increased expression of CFH mRNA CTD PMID:19691856 NCBI chr 1:196,652,033...196,747,504
Ensembl chr 1:196,652,043...196,747,504
Ensembl chr 1:196,652,043...196,747,504
JBrowse link
G CHD9 chromodomain helicase DNA binding protein 9 increases expression EXP Clorgyline results in increased expression of CHD9 mRNA CTD PMID:19691856 NCBI chr16:53,054,982...53,327,502
Ensembl chr16:53,055,033...53,329,150
JBrowse link
G CHIC1 cysteine rich hydrophobic domain 1 increases expression EXP Clorgyline results in increased expression of CHIC1 mRNA CTD PMID:19691856 NCBI chr  X:73,563,045...73,687,109
Ensembl chr  X:73,563,200...73,687,102
JBrowse link
G CHM CHM Rab escort protein increases expression EXP Clorgyline results in increased expression of CHM mRNA CTD PMID:19691856 NCBI chr  X:85,861,180...86,047,558
Ensembl chr  X:85,861,180...86,047,561
JBrowse link
G CLGN calmegin increases expression EXP Clorgyline results in increased expression of CLGN mRNA CTD PMID:19691856 NCBI chr 4:140,388,453...140,427,648
Ensembl chr 4:140,388,453...140,427,661
JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 increases expression EXP Clorgyline results in increased expression of CLIP1 mRNA CTD PMID:19691856 NCBI chr12:122,271,432...122,422,956
Ensembl chr12:122,271,432...122,422,632
JBrowse link
G CNTN3 contactin 3 increases expression EXP Clorgyline results in increased expression of CNTN3 mRNA CTD PMID:19691856 NCBI chr 3:74,262,568...74,614,448
Ensembl chr 3:74,262,568...74,521,140
JBrowse link
G COBLL1 cordon-bleu WH2 repeat protein like 1 increases expression EXP Clorgyline results in increased expression of COBLL1 mRNA CTD PMID:19691856 NCBI chr 2:164,657,931...164,842,076
Ensembl chr 2:164,653,624...164,843,679
JBrowse link
G CPD carboxypeptidase D increases expression EXP Clorgyline results in increased expression of CPD mRNA CTD PMID:19691856 NCBI chr17:30,378,927...30,469,989
Ensembl chr17:30,378,927...30,469,989
JBrowse link
G CPNE9 copine family member 9 increases expression EXP Clorgyline results in increased expression of CPNE9 mRNA CTD PMID:19691856 NCBI chr 3:9,703,833...9,729,908
Ensembl chr 3:9,703,826...9,729,908
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases activity
multiple interactions
EXP Clorgyline results in decreased activity of CYP2B6 protein
Clorgyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:25656918 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G DKKL1 dickkopf like acrosomal protein 1 increases expression EXP Clorgyline results in increased expression of DKKL1 mRNA CTD PMID:19691856 NCBI chr19:49,360,520...49,375,132
Ensembl chr19:49,361,783...49,375,116
JBrowse link
G DMXL1 Dmx like 1 increases expression EXP Clorgyline results in increased expression of DMXL1 mRNA CTD PMID:19691856 NCBI chr 5:119,071,002...119,249,432
Ensembl chr 5:119,037,772...119,249,138
JBrowse link
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 increases expression EXP Clorgyline results in increased expression of DNAJC10 mRNA CTD PMID:19691856 NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,041...182,794,464
JBrowse link
G DST dystonin increases expression EXP Clorgyline results in increased expression of DST mRNA CTD PMID:19691856 NCBI chr 6:56,457,996...56,954,830
Ensembl chr 6:56,457,987...56,954,649
JBrowse link
G DYNC2H1 dynein cytoplasmic 2 heavy chain 1 increases expression EXP Clorgyline results in increased expression of DYNC2H1 mRNA CTD PMID:19691856 NCBI chr11:103,109,426...103,479,863
Ensembl chr11:103,109,410...103,479,863
JBrowse link
G DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 increases expression EXP Clorgyline results in increased expression of DYNC2LI1 mRNA CTD PMID:19691856 NCBI chr 2:43,774,039...43,828,347
Ensembl chr 2:43,774,039...43,810,010
JBrowse link
G ECHDC1 ethylmalonyl-CoA decarboxylase 1 increases expression EXP Clorgyline results in increased expression of ECHDC1 mRNA CTD PMID:19691856 NCBI chr 6:127,288,712...127,344,179
Ensembl chr 6:127,288,712...127,343,609
JBrowse link
G ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression EXP Clorgyline results in increased expression of ESCO1 mRNA CTD PMID:19691856 NCBI chr18:21,529,281...21,600,736
Ensembl chr18:21,529,284...21,600,884
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression EXP Clorgyline results in decreased expression of EZH2 mRNA CTD PMID:19691856 NCBI chr 7:148,807,374...148,884,344
Ensembl chr 7:148,807,383...148,884,321
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP Clorgyline results in increased expression of FAS mRNA CTD PMID:19691856 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FZD3 frizzled class receptor 3 increases expression EXP Clorgyline results in increased expression of FZD3 mRNA CTD PMID:19691856 NCBI chr 8:28,494,212...28,574,268
Ensembl chr 8:28,494,205...28,574,267
JBrowse link
G GABPA GA binding protein transcription factor subunit alpha increases expression EXP Clorgyline results in increased expression of GABPA mRNA CTD PMID:19691856 NCBI chr21:25,734,972...25,772,460
Ensembl chr21:25,734,570...25,772,460
JBrowse link
G GAP43 growth associated protein 43 decreases expression ISO Clorgyline results in decreased expression of GAP43 protein CTD PMID:12480131 NCBI chr 3:115,623,510...115,721,485
Ensembl chr 3:115,623,324...115,721,490
Ensembl chr 3:115,623,324...115,721,490
JBrowse link
G GCC2 GRIP and coiled-coil domain containing 2 increases expression EXP Clorgyline results in increased expression of GCC2 mRNA CTD PMID:19691856 NCBI chr 2:108,448,561...108,509,415
Ensembl chr 2:108,449,191...108,509,415
Ensembl chr 2:108,449,191...108,509,415
JBrowse link
G GK glycerol kinase increases expression EXP Clorgyline results in increased expression of GK mRNA CTD PMID:19691856 NCBI chr  X:30,653,348...30,731,462
Ensembl chr  X:30,653,359...30,731,456
JBrowse link
G GNPDA2 glucosamine-6-phosphate deaminase 2 increases expression EXP Clorgyline results in increased expression of GNPDA2 mRNA CTD PMID:19691856 NCBI chr 4:44,701,795...44,726,634
Ensembl chr 4:44,682,200...44,726,588
JBrowse link
G GOLGA4 golgin A4 increases expression EXP Clorgyline results in increased expression of GOLGA4 mRNA CTD PMID:19691856 NCBI chr 3:37,243,269...37,366,879
Ensembl chr 3:37,243,177...37,366,751
JBrowse link
G GOLGB1 golgin B1 increases expression EXP Clorgyline results in increased expression of GOLGB1 mRNA CTD PMID:19691856 NCBI chr 3:121,663,201...121,751,169
Ensembl chr 3:121,663,199...121,749,767
JBrowse link
G HBBP1 hemoglobin subunit beta pseudogene 1 increases expression EXP Clorgyline results in increased expression of HBBP1 mRNA CTD PMID:19691856 NCBI chr11:5,241,954...5,243,592
Ensembl chr11:5,241,105...5,243,537
JBrowse link
G HBD hemoglobin subunit delta increases expression EXP Clorgyline results in increased expression of HBD mRNA CTD PMID:19691856 NCBI chr11:5,232,838...5,234,483
Ensembl chr11:5,232,678...5,243,657
JBrowse link
G HINT3 histidine triad nucleotide binding protein 3 increases expression EXP Clorgyline results in increased expression of HINT3 mRNA CTD PMID:19691856 NCBI chr 6:125,956,770...125,980,244
Ensembl chr 6:125,956,770...125,980,244
JBrowse link
G IBTK inhibitor of Bruton tyrosine kinase increases expression EXP Clorgyline results in increased expression of IBTK mRNA CTD PMID:19691856 NCBI chr 6:82,169,987...82,247,747
Ensembl chr 6:82,169,986...82,247,754
JBrowse link
G IFT80 intraflagellar transport 80 increases expression EXP Clorgyline results in increased expression of IFT80 mRNA CTD PMID:19691856 NCBI chr 3:160,256,986...160,399,225
Ensembl chr 3:160,256,986...160,399,880
JBrowse link
G KLHDC1 kelch domain containing 1 increases expression EXP Clorgyline results in increased expression of KLHDC1 mRNA CTD PMID:19691856 NCBI chr14:49,690,462...49,753,152
Ensembl chr14:49,693,105...49,753,150
JBrowse link
G KLHL2 kelch like family member 2 increases expression EXP Clorgyline results in increased expression of KLHL2 mRNA CTD PMID:19691856 NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156
JBrowse link
G KLK3 kallikrein related peptidase 3 increases expression EXP Clorgyline results in increased expression of KLK3 mRNA CTD PMID:19691856 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G KTN1 kinectin 1 increases expression EXP Clorgyline results in increased expression of KTN1 mRNA CTD PMID:19691856 NCBI chr14:55,580,207...55,684,584
Ensembl chr14:55,559,072...55,701,526
JBrowse link
G LARP1B La ribonucleoprotein 1B increases expression EXP Clorgyline results in increased expression of LARP1B mRNA CTD PMID:19691856 NCBI chr 4:128,060,655...128,222,931
Ensembl chr 4:128,061,286...128,222,931
JBrowse link
G LIG4 DNA ligase 4 increases expression EXP Clorgyline results in increased expression of LIG4 mRNA CTD PMID:19691856 NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368
JBrowse link
G LRAT lecithin retinol acyltransferase increases expression EXP Clorgyline results in increased expression of LRAT mRNA CTD PMID:19691856 NCBI chr 4:154,740,838...154,753,120
Ensembl chr 4:154,626,945...154,753,120
JBrowse link
G LTB lymphotoxin beta increases expression EXP Clorgyline results in increased expression of LTB mRNA CTD PMID:19691856 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522
JBrowse link
G MAGEA3 MAGE family member A3 increases expression EXP Clorgyline results in increased expression of MAGEA3 mRNA CTD PMID:19691856 NCBI chr  X:152,698,742...152,702,347
Ensembl chr  X:152,698,767...152,702,347
JBrowse link
G MANEA mannosidase endo-alpha increases expression EXP Clorgyline results in increased expression of MANEA mRNA CTD PMID:19691856 NCBI chr 6:95,577,535...95,609,452
Ensembl chr 6:95,577,535...95,609,452
JBrowse link
G MAOA monoamine oxidase A multiple interactions
decreases activity
ISO
EXP
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; [Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine
Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]
CTD PMID:1905457, PMID:3961266, PMID:12818349, PMID:16252076, PMID:21923181, PMID:23009399, PMID:23499958, PMID:27270453, PMID:30036687 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAOB monoamine oxidase B decreases activity
multiple interactions
ISO Clorgyline results in decreased activity of MAOB protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:23499958, PMID:23943324 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MAP9 microtubule associated protein 9 increases expression EXP Clorgyline results in increased expression of MAP9 mRNA CTD PMID:19691856 NCBI chr 4:155,342,658...155,376,970
Ensembl chr 4:155,342,658...155,376,970
JBrowse link
G MBNL2 muscleblind like splicing regulator 2 increases expression EXP Clorgyline results in increased expression of MBNL2 mRNA CTD PMID:19691856 NCBI chr13:97,141,834...97,394,120
Ensembl chr13:97,221,434...97,394,120
JBrowse link
G MIA2 MIA SH3 domain ER export factor 2 increases expression EXP Clorgyline results in increased expression of MIA2 mRNA CTD PMID:19691856 NCBI chr14:39,233,915...39,388,522
Ensembl chr14:39,230,231...39,388,513
JBrowse link
G MIPOL1 mirror-image polydactyly 1 increases expression EXP Clorgyline results in increased expression of MIPOL1 mRNA CTD PMID:19691856 NCBI chr14:37,197,888...37,579,207
Ensembl chr14:37,197,913...37,552,361
JBrowse link
G MOB1B MOB kinase activator 1B increases expression EXP Clorgyline results in increased expression of MOB1B mRNA CTD PMID:19691856 NCBI chr 4:70,901,970...70,988,174
Ensembl chr 4:70,902,326...71,022,449
JBrowse link
G MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking increases expression EXP Clorgyline results in increased expression of MON2 mRNA CTD PMID:19691856 NCBI chr12:62,466,817...62,600,476
Ensembl chr12:62,466,817...62,600,476
JBrowse link
G MOSPD2 motile sperm domain containing 2 increases expression EXP Clorgyline results in increased expression of MOSPD2 mRNA CTD PMID:19691856 NCBI chr  X:14,873,421...14,922,327
Ensembl chr  X:14,873,421...14,922,327
JBrowse link
G MPP7 membrane palmitoylated protein 7 increases expression EXP Clorgyline results in increased expression of MPP7 mRNA CTD PMID:19691856 NCBI chr10:28,050,993...28,303,066
Ensembl chr10:28,050,993...28,334,486
JBrowse link
G MYO6 myosin VI increases expression EXP Clorgyline results in increased expression of MYO6 mRNA CTD PMID:19691856 NCBI chr 6:75,749,203...75,919,537
Ensembl chr 6:75,749,192...75,919,537
JBrowse link
G NDFIP2 Nedd4 family interacting protein 2 increases expression EXP Clorgyline results in increased expression of NDFIP2 mRNA CTD PMID:19691856 NCBI chr13:79,480,722...79,556,077
Ensembl chr13:79,481,124...79,556,075
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression EXP Clorgyline results in increased expression of NFE2L2 mRNA CTD PMID:19691856 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NIPBL NIPBL cohesin loading factor increases expression EXP Clorgyline results in increased expression of NIPBL mRNA CTD PMID:19691856 NCBI chr 5:36,876,769...37,066,413
Ensembl chr 5:36,876,769...37,066,413
JBrowse link
G NPAT nuclear protein, coactivator of histone transcription increases expression EXP Clorgyline results in increased expression of NPAT mRNA CTD PMID:19691856 NCBI chr11:108,155,280...108,222,638
Ensembl chr11:108,157,215...108,222,638
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Clorgyline results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 increases expression EXP Clorgyline results in increased expression of NRIP1 mRNA CTD PMID:19691856 NCBI chr21:14,961,235...15,065,903
Ensembl chr21:14,961,235...15,065,936
JBrowse link
G NSRP1 nuclear speckle splicing regulatory protein 1 increases expression EXP Clorgyline results in increased expression of NSRP1 mRNA CTD PMID:19691856 NCBI chr17:30,116,816...30,186,475
Ensembl chr17:30,115,521...30,186,475
JBrowse link
G NSUN3 NOP2/Sun RNA methyltransferase 3 increases expression EXP Clorgyline results in increased expression of NSUN3 mRNA CTD PMID:19691856 NCBI chr 3:94,063,061...94,131,832
Ensembl chr 3:94,062,980...94,131,832
JBrowse link
G NT5DC1 5'-nucleotidase domain containing 1 increases expression EXP Clorgyline results in increased expression of NT5DC1 mRNA CTD PMID:19691856 NCBI chr 6:116,100,833...116,249,497
Ensembl chr 6:116,100,851...116,249,497
JBrowse link
G NUDCD1 NudC domain containing 1 increases expression EXP Clorgyline results in increased expression of NUDCD1 mRNA CTD PMID:19691856 NCBI chr 8:109,240,919...109,334,087
Ensembl chr 8:109,240,919...109,334,118
JBrowse link
G ODF2L outer dense fiber of sperm tails 2 like increases expression EXP Clorgyline results in increased expression of ODF2L mRNA CTD PMID:19691856 NCBI chr 1:86,346,837...86,396,323
Ensembl chr 1:86,346,824...86,396,342
JBrowse link
G PCM1 pericentriolar material 1 increases expression EXP Clorgyline results in increased expression of PCM1 mRNA CTD PMID:19691856 NCBI chr 8:17,922,784...18,029,948
Ensembl chr 8:17,922,840...18,027,975
Ensembl chr 8:17,922,840...18,027,975
JBrowse link
G PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 increases expression EXP Clorgyline results in increased expression of PCMTD1 mRNA CTD PMID:19691856 NCBI chr 8:51,817,575...51,899,186
Ensembl chr 8:51,817,575...51,899,186
JBrowse link
G PDIK1L PDLIM1 interacting kinase 1 like increases expression EXP Clorgyline results in increased expression of PDIK1L mRNA CTD PMID:19691856 NCBI chr 1:26,109,131...26,125,555
Ensembl chr 1:26,111,165...26,125,555
JBrowse link
G PHF14 PHD finger protein 14 increases expression EXP Clorgyline results in increased expression of PHF14 mRNA CTD PMID:19691856 NCBI chr 7:10,973,872...11,169,618
Ensembl chr 7:10,973,336...11,169,623
Ensembl chr 7:10,973,336...11,169,623
JBrowse link
G PHF3 PHD finger protein 3 increases expression EXP Clorgyline results in increased expression of PHF3 mRNA CTD PMID:19691856 NCBI chr 6:63,635,802...63,726,011
Ensembl chr 6:63,635,820...63,779,336
Ensembl chr 6:63,635,820...63,779,336
JBrowse link
G PHIP pleckstrin homology domain interacting protein increases expression EXP Clorgyline results in increased expression of PHIP mRNA CTD PMID:19691856 NCBI chr 6:78,934,419...79,078,294
Ensembl chr 6:78,934,419...79,078,254
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha increases expression EXP Clorgyline results in increased expression of PIK3C2A mRNA CTD PMID:19691856 NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,983
JBrowse link
G POLK DNA polymerase kappa increases expression EXP Clorgyline results in increased expression of POLK mRNA CTD PMID:19691856 NCBI chr 5:75,511,308...75,605,820
Ensembl chr 5:75,511,756...75,601,144
JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B multiple interactions ISO [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein] CTD PMID:23499958 NCBI chr17:39,626,735...39,636,625
Ensembl chr17:39,626,740...39,636,626
JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 increases expression EXP Clorgyline results in increased expression of PREX2 mRNA CTD PMID:19691856 NCBI chr 8:67,951,918...68,237,032
Ensembl chr 8:67,952,046...68,237,032
JBrowse link
G PRODH2 proline dehydrogenase 2 increases expression EXP Clorgyline results in increased expression of PRODH2 mRNA CTD PMID:19691856 NCBI chr19:35,799,988...35,812,845
Ensembl chr19:35,799,988...35,813,299
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 increases expression EXP Clorgyline results in increased expression of PTPN22 mRNA CTD PMID:19691856 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G RAD50 RAD50 double strand break repair protein increases expression EXP Clorgyline results in increased expression of RAD50 mRNA CTD PMID:19691856 NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349
JBrowse link
G RAD54B RAD54 homolog B increases expression EXP Clorgyline results in increased expression of RAD54B mRNA CTD PMID:19691856 NCBI chr 8:94,371,960...94,475,115
Ensembl chr 8:94,371,960...94,475,115
Ensembl chr 8:94,371,960...94,475,115
JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 increases expression EXP Clorgyline results in increased expression of RAPGEF4 mRNA CTD PMID:19691856 NCBI chr 2:172,735,282...173,052,893
Ensembl chr 2:172,735,274...173,052,893
JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 increases expression EXP Clorgyline results in increased expression of RB1CC1 mRNA CTD PMID:19691856 NCBI chr 8:52,622,458...52,714,466
Ensembl chr 8:52,622,458...52,745,843
JBrowse link
G REV3L REV3 like, DNA directed polymerase zeta catalytic subunit increases expression EXP Clorgyline results in increased expression of REV3L mRNA CTD PMID:19691856 NCBI chr 6:111,299,033...111,483,711
Ensembl chr 6:111,299,028...111,483,715
JBrowse link
G RGPD5 RANBP2 like and GRIP domain containing 5 increases expression EXP Clorgyline results in increased expression of RGPD5 mRNA CTD PMID:19691856 NCBI chr 2:109,760,594...109,857,705
Ensembl chr 2:109,792,758...109,857,705
JBrowse link
G RGS5 regulator of G protein signaling 5 increases expression EXP Clorgyline results in increased expression of RGS5 mRNA CTD PMID:19691856 NCBI chr 1:163,142,299...163,321,735
Ensembl chr 1:163,244,505...163,321,894
Ensembl chr 1:163,244,505...163,321,894
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 increases expression EXP Clorgyline results in increased expression of RICTOR mRNA CTD PMID:19691856 NCBI chr 5:38,937,920...39,074,421
Ensembl chr 5:38,937,920...39,074,399
JBrowse link
G SAMD9 sterile alpha motif domain containing 9 increases expression EXP Clorgyline results in increased expression of SAMD9 mRNA CTD PMID:19691856 NCBI chr 7:93,099,518...93,117,979
Ensembl chr 7:93,099,513...93,118,023
JBrowse link
G SCAF11 SR-related CTD associated factor 11 increases expression EXP Clorgyline results in increased expression of SCAF11 mRNA CTD PMID:19691856 NCBI chr12:45,919,131...45,992,040
Ensembl chr12:45,919,131...45,992,120
JBrowse link
G SELENOP selenoprotein P increases expression EXP Clorgyline results in increased expression of SELENOP mRNA CTD PMID:19691856 NCBI chr 5:42,799,880...42,811,892
Ensembl chr 5:42,799,880...42,887,392
JBrowse link
G SEMA3C semaphorin 3C increases expression EXP Clorgyline results in increased expression of SEMA3C mRNA CTD PMID:19691856 NCBI chr 7:80,742,538...80,922,389
Ensembl chr 7:80,742,538...80,922,359
JBrowse link
G SENP6 SUMO specific peptidase 6 increases expression EXP Clorgyline results in increased expression of SENP6 mRNA CTD PMID:19691856 NCBI chr 6:75,601,864...75,718,281
Ensembl chr 6:75,601,509...75,718,281
JBrowse link
G SENP7 SUMO specific peptidase 7 increases expression EXP Clorgyline results in increased expression of SENP7 mRNA CTD PMID:19691856 NCBI chr 3:101,324,205...101,513,883
Ensembl chr 3:101,324,205...101,513,241
JBrowse link
G SHOC2 SHOC2 leucine rich repeat scaffold protein increases expression EXP Clorgyline results in increased expression of SHOC2 mRNA CTD PMID:19691856 NCBI chr10:110,919,370...111,013,665
Ensembl chr10:110,919,547...111,013,667
Ensembl chr10:110,919,547...111,013,667
JBrowse link
G SLC4A5 solute carrier family 4 member 5 increases expression EXP Clorgyline results in increased expression of SLC4A5 mRNA CTD PMID:19691856 NCBI chr 2:74,216,242...74,343,416
Ensembl chr 2:74,216,242...74,343,414
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 increases expression EXP Clorgyline results in increased expression of SLCO1B1 mRNA CTD PMID:19691856 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLITRK6 SLIT and NTRK like family member 6 increases expression EXP Clorgyline results in increased expression of SLITRK6 mRNA CTD PMID:19691856 NCBI chr13:85,792,790...85,799,419
Ensembl chr13:85,792,790...85,806,683
JBrowse link
G SLK STE20 like kinase increases expression EXP Clorgyline results in increased expression of SLK mRNA CTD PMID:19691856 NCBI chr10:103,967,100...104,029,233
Ensembl chr10:103,967,140...104,029,233
JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression EXP Clorgyline results in increased expression of SMCHD1 mRNA CTD PMID:19691856 NCBI chr18:2,655,726...2,805,017
Ensembl chr18:2,655,738...2,805,017
Ensembl chr18:2,655,738...2,805,017
JBrowse link
G SNORD64 small nucleolar RNA, C/D box 64 increases expression EXP Clorgyline results in increased expression of SNORD64 mRNA CTD PMID:19691856 NCBI chr15:24,985,100...24,985,166
Ensembl chr15:24,985,100...24,985,166
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 increases expression EXP Clorgyline results in increased expression of SOCS2 mRNA CTD PMID:19691856 NCBI chr12:93,569,849...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G STAG2 stromal antigen 2 increases expression EXP Clorgyline results in increased expression of STAG2 mRNA CTD PMID:19691856 NCBI chr  X:123,960,560...124,102,656
Ensembl chr  X:123,960,212...124,422,664
JBrowse link
G STEAP2 STEAP2 metalloreductase increases expression EXP Clorgyline results in increased expression of STEAP2 mRNA CTD PMID:19691856 NCBI chr 7:90,211,740...90,243,408
Ensembl chr 7:90,167,590...90,238,137
JBrowse link
G STXBP4 syntaxin binding protein 4 increases expression EXP Clorgyline results in increased expression of STXBP4 mRNA CTD PMID:19691856 NCBI chr17:54,968,728...55,173,632
Ensembl chr17:54,968,727...55,173,632
JBrowse link
G TAS2R45 taste 2 receptor member 45 increases expression EXP Clorgyline results in increased expression of TAS2R45 mRNA CTD PMID:19691856 Ensembl chr12:11,091,287...11,092,313 JBrowse link
G TBC1D15 TBC1 domain family member 15 increases expression EXP Clorgyline results in increased expression of TBC1D15 mRNA CTD PMID:19691856 NCBI chr12:71,839,759...71,924,313
Ensembl chr12:71,839,707...71,927,248
JBrowse link
G TBC1D8B TBC1 domain family member 8B increases expression EXP Clorgyline results in increased expression of TBC1D8B mRNA CTD PMID:19691856 NCBI chr  X:106,802,673...106,876,150
Ensembl chr  X:106,802,673...106,876,150
JBrowse link
G TCEAL7 transcription elongation factor A like 7 increases expression EXP Clorgyline results in increased expression of TCEAL7 mRNA CTD PMID:19691856 NCBI chr  X:103,330,239...103,332,326
Ensembl chr  X:103,330,229...103,332,326
JBrowse link
G TEX9 testis expressed 9 increases expression EXP Clorgyline results in increased expression of TEX9 mRNA CTD PMID:19691856 NCBI chr15:56,243,973...56,445,883
Ensembl chr15:56,244,009...56,445,997
JBrowse link
G THAP2 THAP domain containing 2 increases expression EXP Clorgyline results in increased expression of THAP2 mRNA CTD PMID:19691856 NCBI chr12:71,664,301...71,680,644
Ensembl chr12:71,664,301...71,680,644
JBrowse link
G TMED5 transmembrane p24 trafficking protein 5 increases expression EXP Clorgyline results in increased expression of TMED5 mRNA CTD PMID:19691856 NCBI chr 1:93,149,742...93,180,413
Ensembl chr 1:93,149,742...93,180,516
JBrowse link
G TMEM106B transmembrane protein 106B increases expression EXP Clorgyline results in increased expression of TMEM106B mRNA CTD PMID:19691856 NCBI chr 7:12,211,294...12,243,367
Ensembl chr 7:12,211,270...12,243,367
JBrowse link
G TMF1 TATA element modulatory factor 1 increases expression EXP Clorgyline results in increased expression of TMF1 mRNA CTD PMID:19691856 NCBI chr 3:69,019,827...69,052,333
Ensembl chr 3:69,019,827...69,052,339
JBrowse link
G TRIP11 thyroid hormone receptor interactor 11 increases expression EXP Clorgyline results in increased expression of TRIP11 mRNA CTD PMID:19691856 NCBI chr14:91,965,991...92,040,134
Ensembl chr14:91,965,991...92,040,896
JBrowse link
G TUT7 terminal uridylyl transferase 7 increases expression EXP Clorgyline results in increased expression of TUT7 mRNA CTD PMID:19691856 NCBI chr 9:86,287,733...86,354,497
Ensembl chr 9:86,287,733...86,354,454
JBrowse link
G UBE2W ubiquitin conjugating enzyme E2 W increases expression EXP Clorgyline results in increased expression of UBE2W mRNA CTD PMID:19691856 NCBI chr 8:73,780,096...73,878,862
Ensembl chr 8:73,780,097...73,878,910
JBrowse link
G UBLCP1 ubiquitin like domain containing CTD phosphatase 1 increases expression EXP Clorgyline results in increased expression of UBLCP1 mRNA CTD PMID:19691856 NCBI chr 5:159,263,290...159,286,036
Ensembl chr 5:159,263,290...159,286,036
JBrowse link
G UPF3B UPF3B regulator of nonsense mediated mRNA decay increases expression EXP Clorgyline results in increased expression of UPF3B mRNA CTD PMID:19691856 NCBI chr  X:119,805,311...119,853,028
Ensembl chr  X:119,805,311...119,852,998
JBrowse link
G UTRN utrophin increases expression EXP Clorgyline results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 6:144,284,955...144,853,034
Ensembl chr 6:144,285,701...144,853,034
JBrowse link
G VCPIP1 valosin containing protein interacting protein 1 increases expression EXP Clorgyline results in increased expression of VCPIP1 mRNA CTD PMID:19691856 NCBI chr 8:66,628,487...66,667,231
Ensembl chr 8:66,628,487...66,667,231
JBrowse link
G VPS13A vacuolar protein sorting 13 homolog A increases expression EXP Clorgyline results in increased expression of VPS13A mRNA CTD PMID:19691856 NCBI chr 9:77,177,353...77,421,537
Ensembl chr 9:77,177,445...77,421,537
JBrowse link
G VPS13C vacuolar protein sorting 13 homolog C increases expression EXP Clorgyline results in increased expression of VPS13C mRNA CTD PMID:19691856 NCBI chr15:61,852,389...62,060,447
Ensembl chr15:61,852,389...62,060,473
JBrowse link
G VPS37A VPS37A subunit of ESCRT-I increases expression EXP Clorgyline results in increased expression of VPS37A mRNA CTD PMID:19691856 NCBI chr 8:17,246,903...17,333,455
Ensembl chr 8:17,246,931...17,302,427
JBrowse link
G WDR17 WD repeat domain 17 increases expression EXP Clorgyline results in increased expression of WDR17 mRNA CTD PMID:19691856 NCBI chr 4:176,065,841...176,182,824
Ensembl chr 4:176,065,834...176,182,818
JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 increases expression EXP Clorgyline results in increased expression of ZBTB1 mRNA CTD PMID:19691856 NCBI chr14:64,504,726...64,533,693
Ensembl chr14:64,503,712...64,533,690
JBrowse link
G ZBTB10 zinc finger and BTB domain containing 10 increases expression EXP Clorgyline results in increased expression of ZBTB10 mRNA CTD PMID:19691856 NCBI chr 8:80,485,593...80,526,265
Ensembl chr 8:80,485,619...80,526,265
JBrowse link
G ZFY zinc finger protein Y-linked increases expression EXP Clorgyline results in increased expression of ZFY mRNA CTD PMID:19691856 NCBI chr  Y:2,935,381...2,982,508
Ensembl chr  Y:2,935,281...2,982,506
JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 increases expression EXP Clorgyline results in increased expression of ZFYVE16 mRNA CTD PMID:19691856 NCBI chr 5:80,407,615...80,483,379
Ensembl chr 5:80,408,013...80,483,379
JBrowse link
G ZNF138 zinc finger protein 138 increases expression EXP Clorgyline results in increased expression of ZNF138 mRNA CTD PMID:19691856 NCBI chr 7:64,794,428...64,860,823
Ensembl chr 7:64,794,388...64,833,681
JBrowse link
G ZNF141 zinc finger protein 141 increases expression EXP Clorgyline results in increased expression of ZNF141 mRNA CTD PMID:19691856 NCBI chr 4:337,814...384,868
Ensembl chr 4:337,814...384,868
JBrowse link
G ZNF280C zinc finger protein 280C increases expression EXP Clorgyline results in increased expression of ZNF280C mRNA CTD PMID:19691856 NCBI chr  X:130,202,707...130,268,899
Ensembl chr  X:130,202,707...130,268,899
JBrowse link
G ZNF280D zinc finger protein 280D increases expression EXP Clorgyline results in increased expression of ZNF280D mRNA CTD PMID:19691856 NCBI chr15:56,630,176...56,733,681
Ensembl chr15:56,652,488...56,918,571
Ensembl chr15:56,652,488...56,918,571
JBrowse link
G ZNF292 zinc finger protein 292 increases expression EXP Clorgyline results in increased expression of ZNF292 mRNA CTD PMID:19691856 NCBI chr 6:87,155,565...87,265,943
Ensembl chr 6:87,152,833...87,265,943
JBrowse link
G ZNF449 zinc finger protein 449 increases expression EXP Clorgyline results in increased expression of ZNF449 mRNA CTD PMID:19691856 NCBI chr  X:135,344,770...135,363,413
Ensembl chr  X:135,344,796...135,363,413
JBrowse link
G ZNF480 zinc finger protein 480 increases expression EXP Clorgyline results in increased expression of ZNF480 mRNA CTD PMID:19691856 NCBI chr19:52,297,169...52,325,927
Ensembl chr19:52,297,169...52,325,922
JBrowse link
G ZNF493 zinc finger protein 493 increases expression EXP Clorgyline results in increased expression of ZNF493 mRNA CTD PMID:19691856 NCBI chr19:21,397,133...21,427,577
Ensembl chr19:21,397,119...21,427,577
Ensembl chr19:21,397,119...21,427,577
JBrowse link
G ZNF567 zinc finger protein 567 increases expression EXP Clorgyline results in increased expression of ZNF567 mRNA CTD PMID:19691856 NCBI chr19:36,666,961...36,723,548
Ensembl chr19:36,687,612...36,727,701
JBrowse link
G ZNF638 zinc finger protein 638 increases expression EXP Clorgyline results in increased expression of ZNF638 mRNA CTD PMID:19691856 NCBI chr 2:71,331,782...71,435,061
Ensembl chr 2:71,276,561...71,435,069
JBrowse link
G ZNF644 zinc finger protein 644 increases expression EXP Clorgyline results in increased expression of ZNF644 mRNA CTD PMID:19691856 NCBI chr 1:90,915,304...91,022,267
Ensembl chr 1:90,915,298...91,022,272
JBrowse link
G ZNF658B zinc finger protein 658B (pseudogene) increases expression EXP Clorgyline results in increased expression of ZNF658B mRNA CTD PMID:19691856 NCBI chr 9:39,443,815...39,464,526
Ensembl chr 9:39,443,815...39,508,885
JBrowse link
G ZNF721 zinc finger protein 721 increases expression EXP Clorgyline results in increased expression of ZNF721 mRNA CTD PMID:19691856 NCBI chr 4:439,988...499,156
Ensembl chr 4:425,815...499,156
JBrowse link
cyanophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Dihydrotestosterone inhibits the reaction [cyanophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
esomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
EXP Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA] CTD PMID:25929522 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
EXP GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein
CTD PMID:23112108, PMID:26095818 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 multiple interactions
increases expression
EXP GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein
CTD PMID:23112108, PMID:26095818 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CDK6 cyclin dependent kinase 6 multiple interactions
increases expression
EXP GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
CTD PMID:23112108, PMID:26095818 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
EXP CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein
CTD PMID:26687534 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity ISO Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions
increases expression
EXP GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A
CTD PMID:26095818 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases expression
EXP CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein
CTD PMID:26687534 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
decreases stability
EXP [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein
CTD PMID:22037238 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAOA monoamine oxidase A decreases activity ISO
EXP
Harmaline results in decreased activity of MAOA protein CTD PMID:15178694, PMID:24373881, PMID:28302559 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299, PMID:12107048 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
increases expression
EXP harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA
CTD PMID:27590872 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases stability
decreases activity
EXP [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein
CTD PMID:22037238 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G TP53 tumor protein p53 increases expression EXP harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases activity
EXP
ISO
AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein
CTD PMID:20732341 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G MAOA monoamine oxidase A decreases activity EXP harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G SLC22A1 solute carrier family 22 member 1 decreases activity
multiple interactions
EXP harman results in decreased activity of SLC22A1 protein
harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD PMID:30189235 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions
decreases activity
EXP harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A2 protein
CTD PMID:30189235 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions
ISO harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,644,898...132,646,051
Ensembl chr 6:132,644,898...132,646,051
JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AXIN2 axin 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr17:65,528,563...65,561,648
Ensembl chr17:65,528,563...65,561,648
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions EXP Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G CCNA1 cyclin A1 increases expression EXP Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNE2 cyclin E2 increases expression EXP Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CDC25A cell division cycle 25A increases expression EXP Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25C cell division cycle 25C increases expression EXP Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression EXP Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases phosphorylation ISO Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C decreases expression EXP Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
Ensembl chr11:2,883,213...2,885,775
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A decreases expression EXP Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B decreases expression EXP Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305
JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 multiple interactions
increases phosphorylation
ISO AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter] CTD PMID:27805061 NCBI chr12:6,570,082...6,607,379
Ensembl chr12:6,570,082...6,614,524
JBrowse link
G CIDEA cell death inducing DFFA like effector a multiple interactions
increases expression
ISO Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein
CTD PMID:27805061 NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
decreases stability
EXP
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein
CTD PMID:22001777 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DIO2 iodothyronine deiodinase 2 increases expression ISO Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions
affects binding
decreases activity
EXP Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein
CTD PMID:21573099, PMID:25751815 NCBI chr21:37,365,573...37,526,358
Ensembl chr21:37,365,573...37,526,358
JBrowse link
G E2F1 E2F transcription factor 1 increases expression EXP Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G E2F2 E2F transcription factor 2 increases expression EXP Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 1:23,505,696...23,531,250
Ensembl chr 1:23,506,438...23,531,233
JBrowse link
G E2F7 E2F transcription factor 7 increases expression EXP Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr12:77,021,251...77,065,580
Ensembl chr12:77,021,248...77,065,569
JBrowse link
G E2F8 E2F transcription factor 8 increases expression EXP Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr11:19,224,063...19,241,655
Ensembl chr11:19,224,063...19,241,620
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FOXM1 forkhead box M1 increases expression EXP Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,681...2,877,155
Ensembl chr12:2,857,681...2,877,155
JBrowse link
G ID2 inhibitor of DNA binding 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
JBrowse link
G INS insulin increases expression EXP Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G LEPR leptin receptor multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MAFA MAF bZIP transcription factor A increases expression EXP Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr 8:143,428,064...143,430,732
Ensembl chr 8:143,419,182...143,430,732
JBrowse link
G MAOA monoamine oxidase A decreases activity ISO
EXP
Harmine results in decreased activity of MAOA protein CTD PMID:24373881, PMID:28302559 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions EXP Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 affects localization EXP Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFATC2 nuclear factor of activated T cells 2 affects localization EXP Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr20:51,386,963...51,562,857
Ensembl chr20:51,386,957...51,562,831
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 affects localization EXP Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 affects localization EXP Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr14:24,366,911...24,379,604
Ensembl chr14:24,365,673...24,379,604
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 increases expression EXP Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr13:27,919,982...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
ISO [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein
CTD PMID:20519739, PMID:27805061 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
increases expression
ISO Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]
Harmine results in increased expression of PPARGC1A protein
CTD PMID:27805061 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRDM16 PR/SET domain 16 multiple interactions
increases expression
ISO Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]
Harmine results in increased expression of PRDM16 protein
CTD PMID:27805061 NCBI chr 1:3,069,203...3,438,621
Ensembl chr 1:3,069,168...3,438,621
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]
Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
CTD PMID:27805061 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G WNT3A Wnt family member 3A multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr 1:228,006,998...228,067,113
Ensembl chr 1:228,006,998...228,061,271
JBrowse link
isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B increases reduction EXP AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 affects reduction
increases reduction
ISO
EXP
Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin
CTD PMID:10510318, PMID:12604212 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,146
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CBR1 carbonyl reductase 1 multiple interactions EXP [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin] CTD PMID:23295225 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CBR3 carbonyl reductase 3 increases metabolic processing EXP CBR3 protein results in increased metabolism of Isatin CTD PMID:19061875 NCBI chr21:36,134,901...36,146,562
Ensembl chr21:36,135,079...36,146,562
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression EXP Isatin results in increased expression of CYP2A6 mRNA CTD PMID:15056799 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases expression EXP Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Isatin results in increased expression of CYP2E1 mRNA CTD PMID:15056799 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DHRS11 dehydrogenase/reductase 11 increases reduction EXP DHRS11 protein results in increased reduction of Isatin CTD PMID:30926317 NCBI chr17:36,591,846...36,600,804
Ensembl chr17:36,591,879...36,600,804
JBrowse link
G DHRS7 dehydrogenase/reductase 7 increases reduction EXP DHRS7 protein results in increased reduction of Isatin CTD PMID:24246760 NCBI chr14:60,144,119...60,169,889
Ensembl chr14:60,144,119...60,169,856
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10] CTD PMID:24316276 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO] CTD PMID:24316276 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2] CTD PMID:24316276 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF] CTD PMID:24316276 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
licocoumarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions EXP licocoumarone binds to and results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr21:37,365,573...37,526,358
Ensembl chr21:37,365,573...37,526,358
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase decreases expression EXP licocoumarone results in decreased expression of MET protein CTD PMID:31838052 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,786...2,697,950
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity EXP Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GLRX glutaredoxin multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GLRX2 glutaredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr 1:193,096,465...193,106,114
Ensembl chr 1:193,090,866...193,106,114
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215, PMID:25943564 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL17A interleukin 17A multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAOB monoamine oxidase B multiple interactions
decreases activity
EXP Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MAPT microtubule associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
EXP
ISO
Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453, PMID:24556215 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564, PMID:31428839 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215, PMID:31428839 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215, PMID:31428839 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PGD phosphogluconate dehydrogenase increases activity EXP Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PRDX6 peroxiredoxin 6 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions
increases activity
ISO oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TXN thioredoxin multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXN2 thioredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
monocrotophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression ISO Monocrotophos results in increased expression of ABCA1 mRNA CTD PMID:32267039 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases expression
increases activity
ISO Monocrotophos results in increased expression of ACACA mRNA
Monocrotophos results in increased activity of ACACA protein
CTD PMID:32267039 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
decreases expression
decreases activity
EXP
ISO
asoxime chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]
Monocrotophos results in decreased expression of ACHE mRNA
[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein
CTD PMID:8783813, PMID:15679473, PMID:15793557, PMID:20026515, PMID:20728503, PMID:21349312, PMID:22285544, PMID:22903060 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression ISO Monocrotophos results in decreased expression of ADIPOQ protein CTD PMID:32267039 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AHR aryl hydrocarbon receptor affects expression
increases expression
multiple interactions
EXP Monocrotophos affects the expression of AHR protein
Monocrotophos results in increased expression of AHR mRNA
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein
CTD PMID:22733800 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression
multiple interactions
EXP Monocrotophos results in increased expression of APEX1 mRNA
Monocrotophos results in increased expression of and affects the localization of APEX1 protein
CTD PMID:28887667 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Monocrotophos results in increased expression of and affects the localization of BAX protein; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]
Monocrotophos results in increased expression of BAX mRNA; Monocrotophos results in increased expression of BAX protein
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression ISO Monocrotophos results in increased expression of BBC3 mRNA CTD PMID:20957986 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
decreases expression
ISO Monocrotophos results in increased expression of BCL2 mRNA; Monocrotophos results in increased expression of BCL2 protein
resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein]
Monocrotophos results in decreased expression of BCL2 mRNA; Monocrotophos results in decreased expression of BCL2 protein
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L2 BCL2 like 2 decreases expression ISO Monocrotophos results in decreased expression of BCL2L2 mRNA; Monocrotophos results in decreased expression of BCL2L2 protein CTD PMID:20957986, PMID:21445290 NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,759
Ensembl chr14:23,298,790...23,311,759
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
ISO Monocrotophos results in increased expression of CASP3 mRNA; Monocrotophos results in increased expression of CASP3 protein; Monocrotophos results in increased expression of CASP3 protein modified form
resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 protein]
CTD PMID:20957986, PMID:21445290, PMID:23833438 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 increases expression ISO Monocrotophos results in increased expression of CASP9 mRNA; Monocrotophos results in increased expression of CASP9 protein; Monocrotophos results in increased expression of CASP9 protein modified form CTD PMID:20957986, PMID:21445290 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase decreases activity ISO Monocrotophos results in decreased activity of CAT protein CTD PMID:22751200 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO Monocrotophos results in increased expression of CDKN1A mRNA; Monocrotophos results in increased expression of CDKN1A protein CTD PMID:20957986, PMID:21445290 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Monocrotophos results in increased expression of and affects the localization of CYCS protein CTD PMID:20957986 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
increases activity
ISO
EXP
Monocrotophos results in increased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein
Monocrotophos results in increased expression of CYP1A1 mRNA; Monocrotophos results in increased expression of CYP1A1 protein
Monocrotophos results in increased activity of CYP1A1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO Monocrotophos results in increased expression of CYP1A2 protein CTD PMID:21445290 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression
increases activity
EXP [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein
Monocrotophos results in increased expression of CYP2B6 mRNA; Monocrotophos results in increased expression of CYP2B6 protein
Monocrotophos results in increased activity of CYP2B6 protein
CTD PMID:22733800 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression
multiple interactions
increases activity
ISO
EXP
Monocrotophos results in increased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein
Monocrotophos results in increased expression of CYP2E1 mRNA; Monocrotophos results in increased expression of CYP2E1 protein
Monocrotophos results in increased activity of CYP2E1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity
increases expression
multiple interactions
EXP Monocrotophos results in increased activity of CYP3A4 protein
Monocrotophos results in increased expression of CYP3A4 mRNA; Monocrotophos results in increased expression of CYP3A4 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein
CTD PMID:22733800 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Monocrotophos results in increased expression of CYP7A1 mRNA CTD PMID:32267039 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G FASN fatty acid synthase increases expression
increases activity
ISO Monocrotophos results in increased expression of FASN mRNA
Monocrotophos results in increased activity of FASN protein
CTD PMID:32267039 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Monocrotophos results in increased expression of FOS protein CTD PMID:20957986, PMID:21445290 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase affects activity
increases activity
multiple interactions
ISO Monocrotophos affects the activity of G6PD protein
Monocrotophos results in increased activity of G6PD protein
[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein
CTD PMID:24248738, PMID:32267039 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCK glucokinase increases activity ISO Monocrotophos results in increased activity of GCK protein CTD PMID:32267039 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GSR glutathione-disulfide reductase decreases activity
multiple interactions
affects activity
ISO Monocrotophos results in decreased activity of GSR protein
[Monocrotophos co-treated with quinalphos] affects the activity of GSR protein
Monocrotophos affects the activity of GSR protein
CTD PMID:22751200, PMID:24248738 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO
EXP
Monocrotophos results in increased expression of GSTP1 mRNA; Monocrotophos results in increased expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein
CTD PMID:21445290, PMID:22733800 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Monocrotophos results in increased expression of HMGCR mRNA CTD PMID:32267039 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G IL2 interleukin 2 decreases response to substance ISO Monocrotophos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Monocrotophos results in increased expression of JUN protein
Monocrotophos results in increased expression of and results in increased phosphorylation of JUN protein
CTD PMID:20957986, PMID:21445290, PMID:28887667 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G LDLR low density lipoprotein receptor increases expression ISO Monocrotophos results in increased expression of LDLR mRNA CTD PMID:32267039 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LIG3 DNA ligase 3 increases expression EXP Monocrotophos results in increased expression of LIG3 mRNA CTD PMID:28887667 NCBI chr17:34,980,504...35,009,743
Ensembl chr17:34,980,512...35,009,743
JBrowse link
G LPIN1 lipin 1 increases activity ISO Monocrotophos results in increased activity of LPIN1 protein CTD PMID:32267039 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
JBrowse link
G LPL lipoprotein lipase increases expression ISO Monocrotophos results in increased expression of LPL mRNA CTD PMID:32267039 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAOA monoamine oxidase A decreases activity ISO Monocrotophos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAOB monoamine oxidase B decreases activity ISO Monocrotophos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Monocrotophos results in decreased expression of MCL1 mRNA; Monocrotophos results in decreased expression of MCL1 protein CTD PMID:20957986, PMID:21445290 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression EXP Monocrotophos results in increased expression of NFE2L2 protein CTD PMID:28887667 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 affects expression
multiple interactions
EXP Monocrotophos affects the expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein
CTD PMID:22733800 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
increases expression
decreases expression
EXP [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
Monocrotophos results in increased expression of NR1I3 mRNA; Monocrotophos results in increased expression of NR1I3 protein
Monocrotophos results in decreased expression of NR1I3 protein
CTD PMID:22733800 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression EXP Monocrotophos results in decreased expression of OGG1 mRNA CTD PMID:28887667 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases expression EXP Monocrotophos results in increased expression of PARP1 mRNA; Monocrotophos results in increased expression of PARP1 protein CTD PMID:28887667 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression ISO Monocrotophos results in decreased expression of PPARA mRNA CTD PMID:32267039 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO Monocrotophos results in increased expression of PPARG mRNA CTD PMID:32267039 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression ISO Monocrotophos results in increased expression of SCARB1 mRNA CTD PMID:32267039 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO Monocrotophos results in increased expression of SREBF1 mRNA CTD PMID:32267039 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 increases expression ISO Monocrotophos results in increased expression of SREBF2 mRNA CTD PMID:32267039 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G TH tyrosine hydroxylase multiple interactions
increases activity
ISO Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor increases expression ISO Monocrotophos results in increased expression of TNF protein CTD PMID:32267039 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression ISO Monocrotophos results in increased expression of TP53 mRNA; Monocrotophos results in increased expression of TP53 protein; Monocrotophos results in increased expression of TRP53 mRNA; Monocrotophos results in increased expression of TRP53 protein CTD PMID:20957986, PMID:21445290 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP Omeprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects expression
multiple interactions
ISO
EXP
Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]
CTD PMID:19483382, PMID:30452898 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP Omeprazole results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases expression EXP Omeprazole results in decreased expression of ABCB4 mRNA CTD PMID:12040753 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO Omeprazole results in increased expression of ABCC3 mRNA CTD PMID:19118567 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects expression ISO Omeprazole affects the expression of ABCC6 mRNA CTD PMID:19483382 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression
multiple interactions
EXP Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]
CTD PMID:20804740, PMID:31348918 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 affects expression ISO Omeprazole affects the expression of ABCG5 mRNA CTD PMID:19483382 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABHD1 abhydrolase domain containing 1 affects expression ISO Omeprazole affects the expression of ABHD1 mRNA CTD PMID:19483382 NCBI chr 2:27,123,780...27,131,114
Ensembl chr 2:27,123,789...27,130,812
JBrowse link
G ABHD14B abhydrolase domain containing 14B affects expression ISO Omeprazole affects the expression of ABHD14B mRNA CTD PMID:19483382 NCBI chr 3:51,968,510...51,974,630
Ensembl chr 3:51,968,510...51,983,409
JBrowse link
G ABHD17A abhydrolase domain containing 17A, depalmitoylase affects expression ISO Omeprazole affects the expression of ABHD17A mRNA CTD PMID:19483382 NCBI chr19:1,876,810...1,885,519
Ensembl chr19:1,876,810...1,885,496
Ensembl chr19:1,876,810...1,885,496
JBrowse link
G ACACA acetyl-CoA carboxylase alpha affects expression ISO Omeprazole affects the expression of ACACA mRNA CTD PMID:19483382 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACADL acyl-CoA dehydrogenase long chain affects expression ISO Omeprazole affects the expression of ACADL mRNA CTD PMID:19483382 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
JBrowse link
G ACO1 aconitase 1 affects expression ISO Omeprazole affects the expression of ACO1 mRNA CTD PMID:19483382 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACO2 aconitase 2 affects expression ISO Omeprazole affects the expression of ACO2 mRNA CTD PMID:19483382 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,469,117...41,528,989
JBrowse link
G ACOT12 acyl-CoA thioesterase 12 affects expression ISO Omeprazole affects the expression of ACOT12 mRNA CTD PMID:19483382 NCBI chr 5:81,309,045...81,394,174
Ensembl chr 5:81,329,996...81,394,179
JBrowse link
G ACOT4 acyl-CoA thioesterase 4 affects expression ISO Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 NCBI chr14:73,591,873...73,595,766
Ensembl chr14:73,591,706...73,596,496
JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 affects expression ISO Omeprazole affects the expression of ADAM15 mRNA CTD PMID:19483382 NCBI chr 1:155,051,316...155,062,775
Ensembl chr 1:155,050,566...155,062,775
JBrowse link
G ADD1 adducin 1 affects expression ISO Omeprazole affects the expression of ADD1 mRNA CTD PMID:19483382 NCBI chr 4:2,843,844...2,930,065
Ensembl chr 4:2,843,857...2,930,076
JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP Omeprazole results in decreased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide affects expression ISO Omeprazole affects the expression of ADH4 mRNA CTD PMID:19483382 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792
JBrowse link
G ADTRP androgen dependent TFPI regulating protein affects expression ISO Omeprazole affects the expression of ADTRP mRNA CTD PMID:19483382 NCBI chr 6:11,713,523...11,779,628
Ensembl chr 6:11,712,054...11,807,046
JBrowse link
G AFM afamin affects expression ISO Omeprazole affects the expression of AFM mRNA CTD PMID:19483382 NCBI chr 4:73,481,745...73,504,001
Ensembl chr 4:73,481,745...73,504,001
JBrowse link
G AGT angiotensinogen affects expression ISO Omeprazole affects the expression of AGT mRNA CTD PMID:19483382 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AGTR1 angiotensin II receptor type 1 affects expression ISO Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 NCBI chr 3:148,697,871...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
decreases activity
increases activity
increases expression
decreases expression
affects localization
increases response to substance
EXP
ISO
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
Omeprazole results in decreased activity of AHR protein
Omeprazole affects the localization of AHR protein
AHR protein results in increased susceptibility to Omeprazole
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9139728, PMID:9395520, PMID:14742684, PMID:16109480, PMID:20171196, PMID:21703235, PMID:21861773, PMID:21924250, PMID:22687989, PMID:23850985, PMID:25797602, PMID:25826687, PMID:26187274, PMID:26272953, PMID:31669099 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 affects expression ISO Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 NCBI chr 1:45,550,779...45,570,051
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 affects expression ISO Omeprazole affects the expression of AKR7A2 mRNA CTD PMID:19483382 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,146
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 affects expression
multiple interactions
ISO Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD PMID:19483382, PMID:22687989 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 affects expression
multiple interactions
ISO Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA
CTD PMID:19483382, PMID:22687989 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 increases expression EXP Omeprazole results in increased expression of ALDH1A3 mRNA CTD PMID:12040753 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member affects expression ISO Omeprazole affects the expression of ALDH2 mRNA CTD PMID:19483382 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 increases expression EXP Omeprazole results in increased expression of ALDH3A1 mRNA CTD PMID:12040753 NCBI chr17:19,737,984...19,748,390
Ensembl chr17:19,737,984...19,748,943
JBrowse link
G ALKBH7 alkB homolog 7 affects expression ISO Omeprazole affects the expression of ALKBH7 mRNA CTD PMID:19483382 NCBI chr19:6,372,794...6,375,250
Ensembl chr19:6,372,794...6,375,250
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 affects expression ISO Omeprazole affects the expression of AP2M1 mRNA CTD PMID:19483382 NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,091
JBrowse link
G APCS amyloid P component, serum affects expression ISO Omeprazole affects the expression of APCS mRNA CTD PMID:19483382 NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865
JBrowse link
G APOA4 apolipoprotein A4 affects expression ISO Omeprazole affects the expression of APOA4 mRNA CTD PMID:19483382 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOH apolipoprotein H affects expression ISO Omeprazole affects the expression of APOH mRNA CTD PMID:19483382 NCBI chr17:66,212,033...66,229,415
Ensembl chr17:66,212,033...66,256,525
JBrowse link
G APOOL apolipoprotein O like affects expression ISO Omeprazole affects the expression of APOOL mRNA CTD PMID:19483382 NCBI chr  X:85,003,852...85,093,315
Ensembl chr  X:85,003,877...85,093,316
JBrowse link
G ARG1 arginase 1 affects expression ISO Omeprazole affects the expression of ARG1 mRNA CTD PMID:19483382 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 affects expression ISO Omeprazole affects the expression of ARL6IP1 mRNA CTD PMID:19483382 NCBI chr16:18,791,667...18,801,549
Ensembl chr16:18,791,669...18,801,572
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions
affects localization
EXP
ISO
Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9395520, PMID:21703235, PMID:25826687 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G ASGR2 asialoglycoprotein receptor 2 affects expression ISO Omeprazole affects the expression of ASGR2 mRNA CTD PMID:19483382 NCBI chr17:7,101,322...7,115,538
Ensembl chr17:7,101,322...7,115,700
JBrowse link
G ATF5 activating transcription factor 5 affects expression ISO Omeprazole affects the expression of ATF5 mRNA CTD PMID:19483382 NCBI chr19:49,928,702...49,933,936
Ensembl chr19:49,928,702...49,933,935
JBrowse link
G ATP5F1E ATP synthase F1 subunit epsilon affects expression ISO Omeprazole affects the expression of ATP5F1E mRNA CTD PMID:19483382 NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345
JBrowse link
G ATP6AP2 ATPase H+ transporting accessory protein 2 affects expression ISO Omeprazole affects the expression of ATP6AP2 mRNA CTD PMID:19483382 NCBI chr  X:40,580,970...40,606,848
Ensembl chr  X:40,579,372...40,606,848
JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A affects expression ISO Omeprazole affects the expression of ATP6V1A mRNA CTD PMID:19483382 NCBI chr 3:113,747,035...113,812,056
Ensembl chr 3:113,747,033...113,812,056
JBrowse link
G ATP6V1F ATPase H+ transporting V1 subunit F affects expression ISO Omeprazole affects the expression of ATP6V1F mRNA CTD PMID:19483382 NCBI chr 7:128,862,856...128,865,847
Ensembl chr 7:128,862,856...128,865,847
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions EXP
ISO
Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
CTD PMID:25337692 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G BAAT bile acid-CoA:amino acid N-acyltransferase affects expression ISO Omeprazole affects the expression of BAAT mRNA CTD PMID:19483382 NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400
Ensembl chr 9:101,354,182...101,385,400
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:30452898 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:30452898 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL6B BCL6B transcription repressor affects expression ISO Omeprazole affects the expression of BCL6B mRNA CTD PMID:19483382 NCBI chr17:7,023,050...7,029,644
Ensembl chr17:7,023,050...7,030,290
JBrowse link
G BMF Bcl2 modifying factor affects expression ISO Omeprazole affects the expression of BMF mRNA CTD PMID:19483382 NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
JBrowse link
G BMX BMX non-receptor tyrosine kinase multiple interactions EXP BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein] CTD PMID:21861773 NCBI chr  X:15,500,777...15,556,519
Ensembl chr  X:15,464,246...15,556,529
JBrowse link
G BNIP3 BCL2 interacting protein 3 affects expression ISO Omeprazole affects the expression of BNIP3 mRNA CTD PMID:19483382 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G BTF3 basic transcription factor 3 affects expression ISO Omeprazole affects the expression of BTF3 mRNA CTD PMID:19483382 NCBI chr 5:73,498,442...73,505,667
Ensembl chr 5:73,498,408...73,505,635
JBrowse link
G C1QA complement C1q A chain decreases expression ISO Omeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G C1QBP complement C1q binding protein affects expression ISO Omeprazole affects the expression of C1QBP mRNA CTD PMID:19483382 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830
JBrowse link
G C1QC complement C1q C chain decreases expression ISO Omeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,633...22,648,110
JBrowse link
G C1S complement C1s affects expression ISO Omeprazole affects the expression of C1S mRNA CTD PMID:19483382 NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032
JBrowse link
G C2CD2 C2 calcium dependent domain containing 2 affects expression ISO Omeprazole affects the expression of C2CD2 mRNA CTD PMID:19483382 NCBI chr21:41,885,110...41,954,018
Ensembl chr21:41,885,112...41,954,018
JBrowse link
G C4BPA complement component 4 binding protein alpha affects expression
decreases expression
ISO Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA
CTD PMID:19483382, PMID:25626140 NCBI chr 1:207,104,232...207,144,972
Ensembl chr 1:207,104,233...207,144,972
JBrowse link
G C4BPB complement component 4 binding protein beta decreases expression ISO Omeprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr 1:207,088,795...207,099,993
Ensembl chr 1:207,088,860...207,099,993
JBrowse link
G C7 complement C7 affects expression ISO Omeprazole affects the expression of C7 mRNA CTD PMID:19483382 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,497...40,984,643
JBrowse link
G C8B complement C8 beta chain affects expression ISO Omeprazole affects the expression of C8B mRNA CTD PMID:19483382 NCBI chr 1:56,929,207...56,974,383
Ensembl chr 1:56,929,207...56,966,140
JBrowse link
G CA2 carbonic anhydrase 2 affects expression ISO Omeprazole affects the expression of CA2 mRNA CTD PMID:19483382 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA3 carbonic anhydrase 3 affects expression ISO Omeprazole affects the expression of CAR3 mRNA CTD PMID:19483382 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CADPS2 calcium dependent secretion activator 2 affects expression ISO Omeprazole affects the expression of CADPS2 mRNA CTD PMID:19483382 NCBI chr 7:122,318,411...122,886,500
Ensembl chr 7:122,318,411...122,886,759
JBrowse link
G CAPRIN1 cell cycle associated protein 1 affects expression ISO Omeprazole affects the expression of CAPRIN1 mRNA CTD PMID:19483382 NCBI chr11:34,051,663...34,102,610
Ensembl chr11:34,051,731...34,102,610
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
affects expression
increases cleavage
EXP
ISO
Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein
CTD PMID:15461867, PMID:18336733, PMID:19251492, PMID:19483382, PMID:25637687, PMID:30452898 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases cleavage EXP Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CAT catalase increases activity ISO Omeprazole results in increased activity of CAT protein CTD PMID:18547560 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBR1 carbonyl reductase 1 affects expression ISO Omeprazole affects the expression of CBR1 mRNA CTD PMID:19483382 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CCKBR cholecystokinin B receptor multiple interactions EXP [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127
JBrowse link
G CCND1 cyclin D1 decreases expression ISO Omeprazole results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Omeprazole results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDO1 cysteine dioxygenase type 1 affects expression ISO Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 NCBI chr 5:115,804,733...115,816,659
Ensembl chr 5:115,804,733...115,816,659
JBrowse link
G CEPT1 choline/ethanolamine phosphotransferase 1 affects expression ISO Omeprazole affects the expression of CEPT1 mRNA CTD PMID:19483382 NCBI chr 1:111,139,436...111,185,104
Ensembl chr 1:111,139,627...111,185,104
JBrowse link
G CES2 carboxylesterase 2 affects expression ISO Omeprazole affects the expression of CES2 mRNA CTD PMID:19483382 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CFI complement factor I affects expression
decreases expression
ISO Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA
CTD PMID:19483382, PMID:25626140 NCBI chr 4:109,730,982...109,802,040
Ensembl chr 4:109,740,694...109,802,179
JBrowse link
G CFTR CF transmembrane conductance regulator affects metabolic processing ISO CFTR protein affects the metabolism of Omeprazole CTD PMID:15319328 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHP1 calcineurin like EF-hand protein 1 affects expression ISO Omeprazole affects the expression of CHP1 mRNA CTD PMID:19483382 NCBI chr15:41,231,156...41,281,887
Ensembl chr15:41,230,839...41,281,887
JBrowse link
G CISD1 CDGSH iron sulfur domain 1 affects expression ISO Omeprazole affects the expression of CISD1 mRNA CTD PMID:19483382 NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586
JBrowse link
G CLCN4 chloride voltage-gated channel 4 affects expression ISO Omeprazole affects the expression of CLCN4 mRNA CTD PMID:19483382 NCBI chr  X:10,156,975...10,237,660
Ensembl chr  X:10,156,975...10,237,660
Ensembl chr  X:10,156,975...10,237,660
JBrowse link
G CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit affects expression ISO Omeprazole affects the expression of CLPP mRNA CTD PMID:19483382 NCBI chr19:6,361,531...6,370,242
Ensembl chr19:6,361,531...6,370,242
JBrowse link
G CLPTM1L CLPTM1 like affects expression ISO Omeprazole affects the expression of CLPTM1L mRNA CTD PMID:19483382 NCBI chr 5:1,317,752...1,345,099
Ensembl chr 5:1,317,752...1,345,099
JBrowse link
G CMBL carboxymethylenebutenolidase homolog affects expression ISO Omeprazole affects the expression of CMBL mRNA CTD PMID:19483382 NCBI chr 5:10,277,595...10,307,902
Ensembl chr 5:10,275,875...10,307,902
JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 affects expression ISO Omeprazole affects the expression of CMPK1 mRNA CTD PMID:19483382 NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,797...47,378,839
JBrowse link
G COPG1 COPI coat complex subunit gamma 1 affects expression ISO Omeprazole affects the expression of COPG1 mRNA CTD PMID:19483382 NCBI chr 3:129,249,575...129,277,773
Ensembl chr 3:129,249,606...129,277,773
JBrowse link
G COPS4 COP9 signalosome subunit 4 affects expression ISO Omeprazole affects the expression of COPS4 mRNA CTD PMID:19483382 NCBI chr 4:83,035,183...83,075,818
Ensembl chr 4:83,034,447...83,075,818
JBrowse link
G COQ3 coenzyme Q3, methyltransferase affects expression ISO Omeprazole affects the expression of COQ3 mRNA CTD PMID:19483382 NCBI chr 6:99,369,401...99,394,223
Ensembl chr 6:99,369,401...99,394,195
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 affects expression ISO Omeprazole affects the expression of COX4I1 mRNA CTD PMID:19483382 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CPN1 carboxypeptidase N subunit 1 affects expression ISO Omeprazole affects the expression of CPN1 mRNA CTD PMID:19483382 NCBI chr10:100,042,193...100,081,869
Ensembl chr10:100,042,193...100,081,869
JBrowse link
G CPQ carboxypeptidase Q affects expression ISO Omeprazole affects the expression of CPQ mRNA CTD PMID:19483382 NCBI chr 8:96,645,242...97,143,501
Ensembl chr 8:96,645,242...97,149,654
JBrowse link
G CREM cAMP responsive element modulator affects expression ISO Omeprazole affects the expression of CREM mRNA CTD PMID:19483382 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CSNK2B casein kinase 2 beta affects expression ISO Omeprazole affects the expression of CSNK2B mRNA CTD PMID:19483382 NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,236...31,670,343
Ensembl chr 6:31,665,236...31,670,343
JBrowse link
G CSRP1 cysteine and glycine rich protein 1 affects expression ISO Omeprazole affects the expression of CSRP1 mRNA CTD PMID:19483382 NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456
JBrowse link
G CTNNA1 catenin alpha 1 affects expression ISO Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G CTSD cathepsin D multiple interactions ISO Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CTSE cathepsin E decreases expression ISO Omeprazole results in decreased expression of CTSE CTD PMID:7575556 NCBI chr 1:206,009,264...206,023,899
Ensembl chr 1:206,009,264...206,023,895
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
EXP Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]
CTD PMID:25826687 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
multiple interactions
decreases activity
increases expression
EXP
ISO
Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
CTD PMID:8647108, PMID:8900397, PMID:9041675, PMID:9139728, PMID:9152597, PMID:9395520, PMID:9860486, PMID:10103034, PMID:10859152, PMID:11454723, PMID:11849738, PMID:12040753, PMID:12623754, PMID:12841937, PMID:14742684, PMID:14987951, PMID:15681896, PMID:15860653, PMID:17202759, PMID:17954527, PMID:18420780, PMID:18502397, PMID:19118567, PMID:20171196, PMID:21666223, PMID:21703235, PMID:21784029, PMID:22687989, PMID:25626140, PMID:25826687, PMID:26272953 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases activity
increases expression
decreases activity
multiple interactions
EXP
ISO
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:9152597, PMID:9744552, PMID:12040753, PMID:12623754, PMID:12841937, PMID:15681896, PMID:15802389, PMID:16035375, PMID:17954527, PMID:18332078, PMID:18420780, PMID:18502397, PMID:19118567, PMID:19230594, PMID:20171196, PMID:21784029, PMID:21924250, PMID:22524704, PMID:22687989, PMID:23274770, PMID:23850985, PMID:24752503, PMID:25626140, PMID:26204831, PMID:27794450, PMID:31863871 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
affects expression
decreases activity
increases expression
EXP
ISO
Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole results in increased expression of CYP1B1 mRNA
CTD PMID:12040753, PMID:12623754, PMID:18420780, PMID:21703235, PMID:25826687 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases activity
increases expression
affects expression
decreases activity
EXP
ISO
Omeprazole results in increased activity of CYP2B6 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
CTD PMID:17954527, PMID:18420780, PMID:19118567, PMID:19483382, PMID:22524704 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases metabolic processing
increases hydroxylation
affects metabolic processing
increases metabolic processing
decreases activity
multiple interactions
EXP CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased hydroxylation of Omeprazole
CYP2C19 protein affects the metabolism of Omeprazole
CYP2C19 protein results in increased metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CTD PMID:8930576, PMID:9600717, PMID:11752104, PMID:12464242, PMID:12467917, PMID:12485723, PMID:12637241, PMID:14586384, PMID:15258107, PMID:15286053, PMID:15306208, PMID:15626586, PMID:16035375, PMID:17565714, PMID:17702393, PMID:18511451, PMID:18520598, PMID:19812348, PMID:20573087, PMID:21277363, PMID:21795468, PMID:21915887, PMID:22634058, PMID:26599973, PMID:31515991 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
decreases activity
EXP
ISO
Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
Omeprazole results in decreased activity of CYP2C9 protein
CTD PMID:15258107, PMID:18420780 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects expression
decreases activity
ISO Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein
CTD PMID:18420780, PMID:19483382 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:15802389 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP2F1 cytochrome P450 family 2 subfamily F member 1 affects expression ISO Omeprazole affects the expression of CYP2F4 mRNA CTD PMID:19483382 NCBI chr19:41,114,292...41,128,381
Ensembl chr19:41,114,432...41,128,381
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 affects expression ISO Omeprazole affects the expression of CYP2J4 mRNA CTD PMID:19483382 NCBI chr 1:59,893,308...59,926,773
Ensembl chr 1:59,893,308...59,926,773
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases activity
increases metabolic processing
affects metabolic processing
increases expression
EXP
ISO
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in decreased activity of CYP3A11 protein; Omeprazole results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Omeprazole
CYP3A4 protein affects the metabolism of Omeprazole
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CTD PMID:7870052, PMID:8930576, PMID:9744552, PMID:12235278, PMID:12485723, PMID:12695340, PMID:15286053, PMID:15466163, PMID:15626586, PMID:15802389, PMID:17041008, PMID:17565714, PMID:17954527, PMID:18420780, PMID:19118567, PMID:19299527, PMID:22634058 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 affects expression
increases expression
ISO
EXP
Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA
CTD PMID:19118567, PMID:19483382 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 increases expression EXP Omeprazole results in increased expression of CYP3A7 mRNA CTD PMID:19118567 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein affects expression ISO Omeprazole affects the expression of DBI mRNA CTD PMID:19483382 NCBI chr 2:119,366,977...119,372,560
Ensembl chr 2:119,366,921...119,372,560
JBrowse link
G DCAF11 DDB1 and CUL4 associated factor 11 affects expression ISO Omeprazole affects the expression of DCAF11 mRNA CTD PMID:19483382 NCBI chr14:24,114,777...24,125,242
Ensembl chr14:24,114,195...24,125,242
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase affects expression ISO Omeprazole affects the expression of DCXR mRNA CTD PMID:19483382 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Omeprazole results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DECR1 2,4-dienoyl-CoA reductase 1 affects expression ISO Omeprazole affects the expression of DECR1 mRNA CTD PMID:19483382 NCBI chr 8:90,001,437...90,053,633
Ensembl chr 8:90,001,405...90,053,633
JBrowse link
G DEXI Dexi homolog affects expression ISO Omeprazole affects the expression of DEXI mRNA CTD PMID:19483382 NCBI chr16:10,928,891...10,942,468
Ensembl chr16:10,928,891...10,942,468
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 affects expression ISO Omeprazole affects the expression of DGAT1 mRNA CTD PMID:19483382 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G DHCR24 24-dehydrocholesterol reductase affects expression ISO Omeprazole affects the expression of DHCR24 mRNA CTD PMID:19483382 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
JBrowse link
G DHRS4 dehydrogenase/reductase 4 affects expression ISO Omeprazole affects the expression of DHRS4 mRNA CTD PMID:19483382 NCBI chr14:23,953,735...23,969,279
Ensembl chr14:23,953,734...23,969,279
JBrowse link
G DHRS7B dehydrogenase/reductase 7B affects expression ISO Omeprazole affects the expression of DHRS7B mRNA CTD PMID:19483382 NCBI chr17:21,123,368...21,192,030
Ensembl chr17:21,123,364...21,193,265
JBrowse link
G DHX16 DEAH-box helicase 16 affects expression ISO Omeprazole affects the expression of DHX16 mRNA CTD PMID:19483382 NCBI chr 6:30,653,127...30,673,006
Ensembl chr 6:30,653,119...30,673,006
JBrowse link
G DMAC2L distal membrane arm assembly complex 2 like affects expression ISO Omeprazole affects the expression of DMAC2L mRNA CTD PMID:19483382 NCBI chr14:50,311,516...50,327,957
Ensembl chr14:50,312,324...50,335,558
JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 affects expression ISO Omeprazole affects the expression of DNAJC3 mRNA CTD PMID:19483382 NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988
JBrowse link
G DPP4 dipeptidyl peptidase 4 affects expression ISO Omeprazole affects the expression of DPP4 mRNA CTD PMID:19483382 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,215
JBrowse link
G DPYD dihydropyrimidine dehydrogenase affects expression ISO Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
JBrowse link
G EARS2 glutamyl-tRNA synthetase 2, mitochondrial affects expression ISO Omeprazole affects the expression of EARS2 mRNA CTD PMID:19483382 NCBI chr16:23,520,754...23,557,375
Ensembl chr16:23,522,016...23,557,731
Ensembl chr16:23,522,016...23,557,731
Ensembl chr16:23,522,016...23,557,731
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 affects expression ISO Omeprazole affects the expression of ECHS1 mRNA CTD PMID:19483382 NCBI chr10:133,362,480...133,373,396
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G ECI1 enoyl-CoA delta isomerase 1 affects expression ISO Omeprazole affects the expression of ECI1 mRNA CTD PMID:19483382 NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300
JBrowse link
G ECI2 enoyl-CoA delta isomerase 2 affects expression ISO Omeprazole affects the expression of ECI2 mRNA CTD PMID:19483382 NCBI chr 6:4,115,693...4,135,591
Ensembl chr 6:4,115,689...4,135,597
JBrowse link
G EEF1G eukaryotic translation elongation factor 1 gamma affects expression ISO Omeprazole affects the expression of EEF1G mRNA CTD PMID:19483382 NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
JBrowse link
G EGF epidermal growth factor multiple interactions ISO Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase affects expression ISO Omeprazole affects the expression of EHHADH mRNA CTD PMID:19483382 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990
JBrowse link
G EIF4A2 eukaryotic translation initiation factor 4A2 affects expression ISO Omeprazole affects the expression of EIF4A2 mRNA CTD PMID:19483382 NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 affects expression ISO Omeprazole affects the expression of EIF4EBP1 mRNA CTD PMID:19483382 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EIF4H eukaryotic translation initiation factor 4H affects expression ISO Omeprazole affects the expression of EIF4H mRNA CTD PMID:19483382 NCBI chr 7:74,174,356...74,197,096
Ensembl chr 7:74,174,245...74,197,101
JBrowse link
G ENC1 ectodermal-neural cortex 1 affects expression ISO Omeprazole affects the expression of ENC1 mRNA CTD PMID:19483382 NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424
JBrowse link
G ENO1 enolase 1 affects expression ISO Omeprazole affects the expression of ENO1 mRNA CTD PMID:19483382 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ENPEP glutamyl aminopeptidase affects expression ISO Omeprazole affects the expression of ENPEP mRNA CTD PMID:19483382 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285
JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Omeprazole affects the expression of ENPP1 mRNA CTD PMID:19483382 NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EPCAM epithelial cell adhesion molecule affects expression ISO Omeprazole affects the expression of EPCAM mRNA CTD PMID:19483382 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601
JBrowse link
G ERP29 endoplasmic reticulum protein 29 affects expression ISO Omeprazole affects the expression of ERP29 mRNA CTD PMID:19483382 NCBI chr12:112,013,340...112,023,449
Ensembl chr12:112,013,348...112,023,449
JBrowse link
G ESD esterase D affects expression ISO Omeprazole affects the expression of ESD mRNA CTD PMID:19483382 NCBI chr13:46,771,256...46,797,700
Ensembl chr13:46,771,256...46,797,420
Ensembl chr13:46,771,256...46,797,420
JBrowse link
G ETFB electron transfer flavoprotein subunit beta affects expression ISO Omeprazole affects the expression of ETFB mRNA CTD PMID:19483382 NCBI chr19:51,345,155...51,366,388
Ensembl chr19:51,345,169...51,366,418
Ensembl chr19:51,345,169...51,366,418
JBrowse link
G FAAH fatty acid amide hydrolase affects expression ISO Omeprazole affects the expression of FAAH mRNA CTD PMID:19483382 NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848
JBrowse link
G FADS2 fatty acid desaturase 2 affects expression ISO Omeprazole affects the expression of FADS2 mRNA CTD PMID:19483382 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
JBrowse link
G FBP1 fructose-bisphosphatase 1 affects expression ISO Omeprazole affects the expression of FBP1 mRNA CTD PMID:19483382 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 affects expression ISO Omeprazole affects the expression of FDFT1 mRNA CTD PMID:19483382 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,304
JBrowse link
G FDPS farnesyl diphosphate synthase affects expression ISO Omeprazole affects the expression of FDPS mRNA CTD PMID:19483382 NCBI chr 1:155,308,801...155,320,665
Ensembl chr 1:155,308,748...155,320,666
JBrowse link
G FDX2 ferredoxin 2 affects expression ISO Omeprazole affects the expression of FDX2 mRNA CTD PMID:19483382 NCBI chr19:10,310,045...10,316,015
Ensembl chr19:10,310,045...10,316,015
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 affects expression ISO Omeprazole affects the expression of FMO1 mRNA CTD PMID:19483382 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G GAMT guanidinoacetate N-methyltransferase affects expression ISO Omeprazole affects the expression of GAMT mRNA CTD PMID:19483382 NCBI chr19:1,397,026...1,401,542
Ensembl chr19:1,397,026...1,401,570
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase affects expression ISO Omeprazole affects the expression of GAPDH mRNA CTD PMID:19483382 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GAST gastrin increases expression ISO Omeprazole results in increased expression of GAST protein CTD PMID:11422300, PMID:12189558, PMID:12763636, PMID:15223672, PMID:16618411, PMID:17652263 NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969
JBrowse link
G GBE1 1,4-alpha-glucan branching enzyme 1 affects expression ISO Omeprazole affects the expression of GBE1 mRNA CTD PMID:19483382 NCBI chr 3:81,489,703...81,761,645
Ensembl chr 3:81,489,703...81,761,645
JBrowse link
G GCHFR GTP cyclohydrolase I feedback regulator affects expression ISO Omeprazole affects the expression of GCHFR mRNA CTD PMID:19483382 NCBI chr15:40,764,068...40,767,708
Ensembl chr15:40,764,068...40,767,708
JBrowse link
G GGH gamma-glutamyl hydrolase affects expression ISO Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 NCBI chr 8:63,015,079...63,038,806
Ensembl chr 8:63,015,079...63,038,806
JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA CTD PMID:22687989 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GJB1 gap junction protein beta 1 affects expression ISO Omeprazole affects the expression of GJB1 mRNA CTD PMID:19483382 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516
Ensembl chr  X:71,212,811...71,225,516
JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Omeprazole affects the expression of GPLD1 mRNA CTD PMID:19483382 NCBI chr 6:24,423,969...24,495,232
Ensembl chr 6:24,424,565...24,495,205
JBrowse link
G GPX1 glutathione peroxidase 1 affects expression ISO Omeprazole affects the expression of GPX1 mRNA CTD PMID:19483382 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:22687989 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,905
JBrowse link
G GPX4 glutathione peroxidase 4 affects expression ISO Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 affects expression ISO Omeprazole affects the expression of GRINA mRNA CTD PMID:19483382 NCBI chr 8:143,990,056...143,993,415
Ensembl chr 8:143,990,056...143,993,415
JBrowse link
G GRPEL1 GrpE like 1, mitochondrial affects expression ISO Omeprazole affects the expression of GRPEL1 mRNA CTD PMID:19483382 NCBI chr 4:7,058,895...7,068,064
Ensembl chr 4:7,058,895...7,068,064
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 multiple interactions
increases expression
ISO [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
Omeprazole results in increased expression of GSTA5 mRNA
CTD PMID:17202759, PMID:22687989 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO Omeprazole results in increased expression of GSTP1 mRNA CTD PMID:19118567 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects expression ISO Omeprazole affects the expression of GSTT1 mRNA CTD PMID:19483382
G GTF2H5 general transcription factor IIH subunit 5 affects expression ISO Omeprazole affects the expression of GTF2H5 mRNA CTD PMID:19483382 NCBI chr 6:158,168,316...158,199,344
Ensembl chr 6:158,168,350...158,199,344
JBrowse link
G GZMA granzyme A affects expression ISO Omeprazole affects the expression of GZMA mRNA CTD PMID:19483382 NCBI chr 5:55,102,646...55,110,252
Ensembl chr 5:55,102,646...55,110,252
JBrowse link
G H3-3B H3.3 histone B affects expression ISO Omeprazole affects the expression of H3F3B mRNA CTD PMID:19483382 NCBI chr17:75,776,434...75,779,779
Ensembl chr17:75,776,434...75,785,893
JBrowse link
G HAL histidine ammonia-lyase affects expression ISO Omeprazole affects the expression of HAL mRNA CTD PMID:19483382 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365
JBrowse link
G HAMP hepcidin antimicrobial peptide increases expression
multiple interactions
increases secretion
EXP
ISO
Omeprazole results in increased expression of HAMP mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased secretion of HAMP protein
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
CTD PMID:31669099 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
JBrowse link
G HAO2 hydroxyacid oxidase 2 affects expression ISO Omeprazole affects the expression of HAO2 mRNA CTD PMID:19483382 NCBI chr 1:119,361,913...119,394,130
Ensembl chr 1:119,368,779...119,394,130
JBrowse link
G HBA1 hemoglobin subunit alpha 1 affects expression ISO Omeprazole affects the expression of HBA-A2 mRNA CTD PMID:19483382 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
JBrowse link
G HBB hemoglobin subunit beta affects expression ISO Omeprazole affects the expression of HBB mRNA CTD PMID:19483382 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HDC histidine decarboxylase affects expression
increases stability
increases expression
multiple interactions
ISO Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein
CTD PMID:12763636, PMID:19483382 NCBI chr15:50,241,945...50,266,049
Ensembl chr15:50,241,947...50,265,965
JBrowse link
G HGD homogentisate 1,2-dioxygenase affects expression ISO Omeprazole affects the expression of HGD mRNA CTD PMID:19483382 NCBI chr 3:120,628,168...120,682,555
Ensembl chr 3:120,628,172...120,682,269
JBrowse link
G HLA-B major histocompatibility complex, class I, B affects expression EXP Omeprazole affects the expression of HLA-B mRNA CTD PMID:25811541 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,269,491...31,357,188
JBrowse link
G HLA-DMA major histocompatibility complex, class II, DM alpha affects expression EXP Omeprazole affects the expression of HLA-DMA mRNA CTD PMID:25811541 NCBI chr 6:32,948,618...32,953,097
Ensembl chr 6:32,948,613...32,969,094
JBrowse link
G HLA-E major histocompatibility complex, class I, E affects expression ISO Omeprazole affects the expression of RT1-S3 mRNA CTD PMID:19483382 NCBI chr 6:30,489,508...30,494,194
Ensembl chr 6:30,489,509...30,494,194
JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression EXP Omeprazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,130
Ensembl chr 6:29,826,967...29,831,125
JBrowse link
G HMGN1 high mobility group nucleosome binding domain 1 affects expression ISO Omeprazole affects the expression of HMGN1 mRNA CTD PMID:19483382 NCBI chr21:39,342,315...39,349,088
Ensembl chr21:39,342,315...39,349,647
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
CTD PMID:16712795, PMID:27725188 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 affects expression ISO Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G HPS5 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 affects expression ISO Omeprazole affects the expression of HPS5 mRNA CTD PMID:19483382 NCBI chr11:18,278,670...18,322,498
Ensembl chr11:18,278,668...18,322,198
JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 affects expression ISO Omeprazole affects the expression of HSD17B4 mRNA CTD PMID:19483382 NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,473...119,637,199
JBrowse link
G HSDL2 hydroxysteroid dehydrogenase like 2 affects expression ISO Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 NCBI chr 9:112,380,052...112,472,410
Ensembl chr 9:112,380,080...112,472,405
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A decreases expression
multiple interactions
ISO Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
CTD PMID:15223672, PMID:16945336 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283
JBrowse link
G HTRA1 HtrA serine peptidase 1 affects expression ISO Omeprazole affects the expression of HTRA1 mRNA CTD PMID:19483382 NCBI chr10:122,461,553...122,514,907
Ensembl chr10:122,458,551...122,514,907
JBrowse link
G IER3 immediate early response 3 multiple interactions EXP [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548
JBrowse link
G IFNG interferon gamma multiple interactions EXP Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:19232345 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 affects expression ISO Omeprazole affects the expression of IGF1 mRNA CTD PMID:19483382 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit affects expression ISO Omeprazole affects the expression of IGFALS mRNA CTD PMID:19483382 NCBI chr16:1,790,413...1,794,908
Ensembl chr16:1,790,413...1,794,971
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 affects expression ISO Omeprazole affects the expression of IGFBP2 mRNA CTD PMID:19483382 NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:32418911 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein] CTD PMID:25637687, PMID:32418911 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IMPA1 inositol monophosphatase 1 affects expression ISO Omeprazole affects the expression of IMPA1 mRNA CTD PMID:19483382 NCBI chr 8:81,656,914...81,686,325
Ensembl chr 8:81,656,914...81,686,331
JBrowse link
G INHBE inhibin subunit beta E affects expression ISO Omeprazole affects the expression of INHBE mRNA CTD PMID:19483382 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G ISYNA1 inositol-3-phosphate synthase 1 affects expression ISO Omeprazole affects the expression of ISYNA1 mRNA CTD PMID:19483382 NCBI chr19:18,434,388...18,438,649
Ensembl chr19:18,434,388...18,438,167
JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 affects expression ISO Omeprazole affects the expression of ITIH4 mRNA CTD PMID:19483382 NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688
JBrowse link
G JAK1 Janus kinase 1 affects expression ISO Omeprazole affects the expression of JAK1 mRNA CTD PMID:19483382 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,229...65,067,754
JBrowse link
G KDELR2 KDEL endoplasmic reticulum protein retention receptor 2 affects expression ISO Omeprazole affects the expression of KDELR2 mRNA CTD PMID:19483382 NCBI chr 7:6,461,089...6,484,152
Ensembl chr 7:6,445,953...6,484,190
JBrowse link
G KDR kinase insert domain receptor affects expression
multiple interactions
ISO Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]
CTD PMID:19483382, PMID:26272953 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KRT8 keratin 8 affects expression ISO Omeprazole affects the expression of KRT8 mRNA CTD PMID:19483382 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G LCAT lecithin-cholesterol acyltransferase affects expression ISO Omeprazole affects the expression of LCAT mRNA CTD PMID:19483382 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 affects expression ISO Omeprazole affects the expression of LCMT1 mRNA CTD PMID:19483382 NCBI chr16:25,111,702...25,178,231
Ensembl chr16:25,111,731...25,178,231
JBrowse link
G LIPC lipase C, hepatic type affects expression ISO Omeprazole affects the expression of LIPC mRNA CTD PMID:19483382 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LOX lysyl oxidase affects expression ISO Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,360
JBrowse link
G LRP3 LDL receptor related protein 3 affects expression ISO Omeprazole affects the expression of LRP3 mRNA CTD PMID:19483382 NCBI chr19:33,194,330...33,208,864
Ensembl chr19:33,177,603...33,208,864
JBrowse link
G MAN2B1 mannosidase alpha class 2B member 1 affects expression ISO Omeprazole affects the expression of MAN2B1 mRNA CTD PMID:19483382 NCBI chr19:12,646,511...12,666,742
Ensembl chr19:12,646,511...12,666,742
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 affects expression ISO Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:17406807 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MASP2 mannan binding lectin serine peptidase 2 affects expression ISO Omeprazole affects the expression of MASP2 mRNA CTD PMID:19483382 NCBI chr 1:11,026,523...11,047,239
Ensembl chr 1:11,026,523...11,047,239
JBrowse link
G ME1 malic enzyme 1 affects expression
multiple interactions
ISO Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA
CTD PMID:19483382, PMID:22687989 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions ISO Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein] CTD PMID:16934674 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMUT methylmalonyl-CoA mutase affects expression ISO Omeprazole affects the expression of MMUT mRNA CTD PMID:19483382 NCBI chr 6:49,430,360...49,463,298
Ensembl chr 6:49,430,360...49,463,253
JBrowse link
G MPO myeloperoxidase multiple interactions
decreases activity
ISO Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Ome