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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorferron
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Accession:CHEBI:38620 term browser browse the term
Definition:An organochlorine compound that has formula C10H7ClO3.
Synonyms:exact_synonym: 3-chloro-7-hydroxy-4-methyl-2H-chromen-2-one
 related_synonym: 3-Chloro-4-methyl-7-hydroxycoumarin;   3-Chloro-7-hydroxy-4-methyl-2-benzopyrone;   3-chloro-7-hydroxy-4-methyl-2H-1-benzopyran-2-one;   7-Hydroxy-4-methyl-3-chlorocoumarin;   Chlorferone;   Formula=C10H7ClO3;   InChI=1S/C10H7ClO3/c1-5-7-3-2-6(12)4-8(7)14-10(13)9(5)11/h2-4,12H,1H3;   InChIKey=ODZHLDRQCZXQFQ-UHFFFAOYSA-N;   SMILES=Cc1c(Cl)c(=O)oc2cc(O)ccc12
 xref: Beilstein:156298;   CAS:6174-86-3


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coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) decreases activity EXP Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33844597 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G AR androgen receptor multiple interactions EXP Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Coumaphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP Coumaphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 increases expression EXP Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 4:83,535,587...83,605,875
Ensembl chr 4:83,535,914...83,605,875 		JBrowse link
G LIF LIF interleukin 6 family cytokine increases expression EXP Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP
ISO		 Coumaphos binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP
ISO		 Coumaphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G RARA retinoic acid receptor alpha increases activity EXP Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP Coumaphos binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G TP53 tumor protein p53 affects activity EXP Coumaphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        inhibitor 22530
          hyaluronic acid synthesis inhibitor 36
            4-methylumbelliferone 36
              chlorferron 12
                coumaphos 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  oxacycle 19999
                                    benzopyran 12753
                                      1-benzopyran 12488
                                        chromenes 4774
                                          chromenone 4726
                                            coumarins 4495
                                              hydroxycoumarin 363
                                                umbelliferone 114
                                                  4-methylumbelliferone 36
                                                    chlorferron 12
                                                      coumaphos 12
paths to the root