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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,3-difluorobenzene
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Accession:CHEBI:38584 term browser browse the term
Definition:A difluorobenzene carrying fluoro groups at positions 1 and 3.
Synonyms:related_synonym: 1,3-Difluorbenzol;   Formula=C6H4F2;   InChI=1S/C6H4F2/c7-5-2-1-3-6(8)4-5/h1-4H;   InChIKey=UEMGWPRHOOEKTA-UHFFFAOYSA-N;   SMILES=Fc1cccc(F)c1;   m-difluorobenzene;   meta-difluorobenzene
 xref: Beilstein:1904537;   CAS:372-18-9;   Gmelin:200891;   PMID:15535712;   PMID:22707282;   Patent:CN101607874;   Patent:CN1634895;   Patent:CN1765887;   Reaxys:1904537

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diflubenzuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP1A1 protein CTD PMID:8812189 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP3A23-3A1 protein CTD PMID:8812189 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects binding ISO Diflubenzuron binds to CYP3A4 protein CTD PMID:32278787 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diflubenzuron results in increased activity of NR1I2 protein CTD PMID:16565514 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
diflunisal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diflunisal results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Diflunisal results in increased expression of IL1B mRNA CTD PMID:15135310 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression EXP Diflunisal results in increased expression of IL6 mRNA CTD PMID:15135310 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Diflunisal affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Diflunisal results in increased expression of NOS2 mRNA CTD PMID:15135310 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP Diflunisal results in increased expression of TNF mRNA CTD PMID:15135310 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ttr transthyretin affects binding
multiple interactions		 ISO Diflunisal binds to TTR protein mutant form
[Diflunisal binds to TTR protein mutant form] which results in decreased susceptibility to Urea; Diflunisal results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]		 CTD PMID:17701470 PMID:27093678 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Diflunisal results in decreased activity of UGT1A1 protein CTD PMID:15593333 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Diflunisal CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Diflunisal CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation		 ISO Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Diflunisal; UGT2B7 protein results in increased glucuronidation of Diflunisal		 CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link
fluconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb9 ATP binding cassette subfamily B member 9 decreases expression EXP Fluconazole results in decreased expression of ABCB9 mRNA CTD PMID:16643972 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP Fluconazole results in decreased expression of ADH1 mRNA CTD PMID:16643972 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Fluconazole results in increased expression of AKR7A3 mRNA CTD PMID:16643972 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP Fluconazole results in decreased expression of APOA4 mRNA CTD PMID:16643972 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Fluconazole results in increased expression of CES2 mRNA CTD PMID:16643972 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects activity ISO Fluconazole affects the activity of CYP17A1 protein CTD PMID:31330226 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione CTD PMID:31330226 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Fluconazole results in increased expression of CYP1A2 mRNA CTD PMID:16730040 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Fluconazole results in increased expression of CYP26A1 mRNA CTD PMID:19429397 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression ISO Fluconazole results in increased expression of CYP26B1 mRNA CTD PMID:19429397 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA] CTD PMID:16730040 PMID:25656644 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Fluconazole results in decreased expression of CYP2C mRNA CTD PMID:16643972 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Fluconazole results in increased expression of CYP2C55 mRNA CTD PMID:16730040 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity
multiple interactions
increases metabolic processing		 ISO Fluconazole results in decreased activity of CYP2C19 protein
[Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased metabolism of Fluconazole		 CTD PMID:12464242 PMID:15843491 PMID:17702393 PMID:19328226 PMID:26599973 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Fluconazole results in increased expression of CYP2C29 mRNA CTD PMID:16730040 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression EXP Fluconazole results in decreased expression of CYP2G1 mRNA CTD PMID:16643972 NCBI chr 1:83,626,639...83,638,154
Ensembl chr 1:83,626,639...83,637,780 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression ISO Fluconazole results in decreased expression of CYP2J9 mRNA CTD PMID:16730040 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression		 EXP Fluconazole results in increased expression of CYP3A23-3A1 mRNA
Fluconazole affects the expression of CYP3A23-3A1 mRNA		 CTD PMID:16643972 PMID:20623750 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Fluconazole results in decreased activity of CYP3A4 protein CTD PMID:15784650 PMID:15843491 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Fluconazole results in increased expression of CYP3A13 mRNA CTD PMID:16643972 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance
multiple interactions		 ISO Fluconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Fluconazole
CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]		 CTD PMID:16989930 PMID:18694951 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Fluconazole results in increased expression of GSTM1 mRNA CTD PMID:16730040 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Fluconazole results in decreased expression of JUND mRNA CTD PMID:16643972 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Fluconazole results in increased expression of LCN2 mRNA CTD PMID:20623750 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 increases expression ISO Fluconazole results in increased expression of MARK2 mRNA CTD PMID:16730040 NCBI chr 1:222,525,547...222,590,727
Ensembl chr 1:222,525,990...222,590,220 		JBrowse link
G Mpo myeloperoxidase increases expression EXP Fluconazole results in increased expression of MPO mRNA CTD PMID:20623750 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Fluconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:17438109 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
increases response to substance
multiple interactions		 ISO NR1I3 protein affects the susceptibility to Fluconazole
NR1I3 results in increased susceptibility to Fluconazole
NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP3A11 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]		 CTD PMID:23721867 PMID:25656644 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression
multiple interactions
increases expression		 EXP
ISO		 Fluconazole results in decreased expression of POR mRNA
NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]		 CTD PMID:16643972 PMID:16730040 PMID:25656644 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Fluconazole results in increased expression of PPARG mRNA CTD PMID:20623750 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Slc13a2 solute carrier family 13 member 2 decreases expression ISO Fluconazole results in decreased expression of SLC13A2 mRNA CTD PMID:16730040 NCBI chr10:65,664,665...65,692,046
Ensembl chr10:65,664,667...65,692,023 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression EXP Fluconazole results in decreased expression of SLC6A13 mRNA CTD PMID:16643972 NCBI chr 4:153,874,942...153,912,185
Ensembl chr 4:153,874,852...153,912,155 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Fluconazole results in increased expression of SLCO1A4 mRNA CTD PMID:16730040 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Fluconazole results in decreased expression of SRD5A1 mRNA CTD PMID:16643972 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Fluconazole results in increased expression of STAR mRNA CTD PMID:23038793 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP Fluconazole affects the expression of UGT1A9 mRNA CTD PMID:20623750 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Fluconazole results in increased expression of UGT2B1 mRNA CTD PMID:16643972 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:22,597,103...22,619,968 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      molecular entity 19880
        polyatomic entity 19794
          heteroatomic molecular entity 19719
            halide 18134
              organohalogen compound 17882
                organofluorine compound 10852
                  fluorobenzenes 1656
                    difluorobenzene 619
                      1,3-difluorobenzene 49
                        2,6-difluorobenzenesulfonamide 0
                        3,5-difluorobenzenesulfonamide 0
                        diflubenzuron 5
                        diflunisal 11
                        fluconazole + 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon group molecular entity 19679
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic aromatic compound 19233
                                  benzenoid aromatic compound 17350
                                    benzenes 17091
                                      fluorobenzenes 1656
                                        difluorobenzene 619
                                          1,3-difluorobenzene 49
                                            2,6-difluorobenzenesulfonamide 0
                                            3,5-difluorobenzenesulfonamide 0
                                            diflubenzuron 5
                                            diflunisal 11
                                            fluconazole + 38
paths to the root