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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,5-xylenol
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Accession:CHEBI:38572 term browser browse the term
Definition:A member of the class of phenols that phenol substituted by methyl groups at positions 3 and 5.
Synonyms:exact_synonym: 3,5-dimethylphenol
 related_synonym: 1,3,5-Xylenol;   1,5-Dimethyl-3-hyperoxybenzene;   3,5-Dmp;   Formula=C8H10O;   InChI=1S/C8H10O/c1-6-3-7(2)5-8(9)4-6/h3-5,9H,1-2H3;   InChIKey=TUAMRELNJMMDMT-UHFFFAOYSA-N;   SMILES=Cc1cc(C)cc(O)c1;   Sym-m-xylenol
 xref: Beilstein:774117;   CAS:108-68-9
 xref_mesh: MESH:C016834
 xref: PMID:6989805;   PMID:8832438;   Reaxys:774117


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3,5-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation
multiple interactions
ISO CYP1A2 protein results in increased oxidation of 3,5-xylenol analog
[CYP1A2 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD PMID:27665777 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases oxidation
ISO [CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
ISO [CYP2C19 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases oxidation
ISO [CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 3,5-xylenol analog results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 3,5-xylenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 3,5-xylenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
4-chloro-3,5-dimethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO chloroxylenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chloroxylenol binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity
multiple interactions
ISO chloroxylenol affects the activity of SCN4A protein polymorphism
chloroxylenol binds to and results in decreased activity of SCN4A protein
CTD PMID:11282107 PMID:14662728 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chloroxylenol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            xenobiotic metabolite 14478
              3,5-xylenol 13
                4-chloro-3,5-dimethylphenol 7
                XMC 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  cyclic hydrocarbon 17078
                                    monocyclic hydrocarbon 5831
                                      annulene 5656
                                        aromatic annulene 5656
                                          benzene 5656
                                            alkylbenzene 3372
                                              methylbenzene 3237
                                                xylene 85
                                                  m-xylene 42
                                                    3,5-xylenol 13
                                                      4-chloro-3,5-dimethylphenol 7
                                                      XMC 0
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