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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,5-xylenol
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Accession:CHEBI:38572 term browser browse the term
Definition:A member of the class of phenols that phenol substituted by methyl groups at positions 3 and 5.
Synonyms:exact_synonym: 3,5-dimethylphenol
 related_synonym: 1,3,5-Xylenol;   1,5-Dimethyl-3-hyperoxybenzene;   3,5-Dmp;   Formula=C8H10O;   InChI=1S/C8H10O/c1-6-3-7(2)5-8(9)4-6/h3-5,9H,1-2H3;   InChIKey=TUAMRELNJMMDMT-UHFFFAOYSA-N;   SMILES=Cc1cc(C)cc(O)c1;   Sym-m-xylenol
 xref: Beilstein:774117;   CAS:108-68-9
 xref_mesh: MESH:C016834
 xref: PMID:6989805;   PMID:8832438;   Reaxys:774117


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3,5-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation
multiple interactions
ISO CYP1A2 protein results in increased oxidation of 3,5-xylenol analog
[CYP1A2 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD PMID:27665777 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases oxidation
ISO [CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
ISO [CYP2C19 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases oxidation
ISO [CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 3,5-xylenol analog results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 3,5-xylenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 3,5-xylenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
4-chloro-3,5-dimethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity
multiple interactions
ISO chloroxylenol affects the activity of SCN4A protein polymorphism
chloroxylenol binds to and results in decreased activity of SCN4A protein
CTD PMID:11282107, PMID:14662728 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19791
    role 19738
      biological role 19738
        biochemical role 19290
          metabolite 19271
            xenobiotic metabolite 14041
              3,5-xylenol 8
                4-chloro-3,5-dimethylphenol 1
                XMC 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19791
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19676
                    main group molecular entity 19676
                      s-block molecular entity 19434
                        hydrogen molecular entity 19424
                          hydrides 18687
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17969
                                  cyclic hydrocarbon 17058
                                    monocyclic hydrocarbon 5765
                                      annulene 5592
                                        aromatic annulene 5592
                                          benzene 5592
                                            alkylbenzene 3345
                                              methylbenzene 3207
                                                xylene 81
                                                  m-xylene 38
                                                    3,5-xylenol 8
                                                      4-chloro-3,5-dimethylphenol 1
                                                      XMC 0
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