CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 3,5-xylenol
Accession: CHEBI:38572
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Definition: A member of the class of phenols that phenol substituted by methyl groups at positions 3 and 5.
Synonyms: exact_synonym: 3,5-dimethylphenol
related_synonym: 1,3,5-Xylenol; 1,5-Dimethyl-3-hyperoxybenzene; 3,5-Dmp; Formula=C8H10O; InChI=1S/C8H10O/c1-6-3-7(2)5-8(9)4-6/h3-5,9H,1-2H3; InChIKey=TUAMRELNJMMDMT-UHFFFAOYSA-N; SMILES=Cc1cc(C)cc(O)c1; Sym-m-xylenol
xref: Beilstein:774117; CAS:108-68-9
xref_mesh: MESH:C016834
xref: PMID:6989805; PMID:8832438; Reaxys:774117
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases oxidation multiple interactions
ISO
CYP1A2 protein results in increased oxidation of 3,5-xylenol analog [CYP1A2 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD
PMID:27665777
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions increases oxidation
ISO
[CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD
PMID:27665777
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
multiple interactions increases oxidation
ISO
[CYP2C19 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD
PMID:27665777
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions increases oxidation
ISO
[CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog
CTD
PMID:27665777
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
3,5-xylenol analog results in increased activity of NR1I2 protein
CTD
PMID:27665777
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
3,5-xylenol results in increased activity of TRPA1 protein
CTD
PMID:29658714
NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
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Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases activity
ISO
3,5-xylenol results in increased activity of TRPV3 protein
CTD
PMID:29658714
NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
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Ar
androgen receptor
multiple interactions
ISO
chloroxylenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Esr1
estrogen receptor 1
multiple interactions
ISO
chloroxylenol binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
chloroxylenol binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
chloroxylenol binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
chloroxylenol binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Scn4a
sodium voltage-gated channel alpha subunit 4
affects activity multiple interactions
ISO
chloroxylenol affects the activity of SCN4A protein polymorphism chloroxylenol binds to and results in decreased activity of SCN4A protein
CTD
PMID:11282107 PMID:14662728
NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
chloroxylenol binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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